| Year |
Citation |
Score |
| 2024 |
Seetharaman A, Galagali H, Linarte E, Liu MHX, Cohen JD, Chetal K, Sadreyev R, Tate AJ, Montgomery TA, Ruvkun G. SynMuv B gene activity is down-regulated during a viral infection to enhance RNA interference. Biorxiv : the Preprint Server For Biology. PMID 39071373 DOI: 10.1101/2024.07.12.603258 |
0.392 |
|
| 2024 |
Yanagi KS, Jochim B, Kunjo SO, Breen P, Ruvkun G, Lehrbach N. Mutations in nucleotide metabolism genes bypass proteasome defects in png-1/NGLY1-deficient Caenorhabditis elegans. Plos Biology. 22: e3002720. PMID 38991033 DOI: 10.1371/journal.pbio.3002720 |
0.375 |
|
| 2024 |
Meisel JD, Wiesenthal PP, Mootha VK, Ruvkun G. CMTR-1 RNA methyltransferase mutations activate widespread expression of a dopaminergic neuron-specific mitochondrial complex I gene. Current Biology : Cb. PMID 38810637 DOI: 10.1016/j.cub.2024.04.079 |
0.402 |
|
| 2024 |
Warnhoff K, Bhattacharya S, Snoozy J, Breen PC, Ruvkun G. Hypoxia-inducible factor induces cysteine dioxygenase and promotes cysteine homeostasis in . Elife. 12. PMID 38349720 DOI: 10.7554/eLife.89173 |
0.358 |
|
| 2024 |
Meisel JD, Miranda M, Skinner OS, Wiesenthal PP, Wellner SM, Jourdain AA, Ruvkun G, Mootha VK. Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism. Cell. PMID 38215760 DOI: 10.1016/j.cell.2023.12.010 |
0.292 |
|
| 2023 |
Warnhoff K, Snoozy J, Breen PC, Ruvkun G. Hypoxia-inducible factor promotes cysteine homeostasis in . Biorxiv : the Preprint Server For Biology. PMID 37205365 DOI: 10.1101/2023.05.04.538701 |
0.321 |
|
| 2022 |
Mao K, Breen P, Ruvkun G. The ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways. Proceedings of the National Academy of Sciences of the United States of America. 119: e2215966119. PMID 36445965 DOI: 10.1073/pnas.2215966119 |
0.353 |
|
| 2022 |
Ruvkun G, Lehrbach N. Regulation and Functions of the ER-Associated Nrf1 Transcription Factor. Cold Spring Harbor Perspectives in Biology. PMID 35940907 DOI: 10.1101/cshperspect.a041266 |
0.386 |
|
| 2022 |
Ji F, Bonilla G, Krykbaev R, Ruvkun G, Tabach Y, Sadreyev RI. DEPCOD: a tool to detect and visualize co-evolution of protein domains. Nucleic Acids Research. PMID 35536332 DOI: 10.1093/nar/gkac349 |
0.303 |
|
| 2022 |
Govindan JA, Jayamani E, Zhang X, Breen P, Larkins-Ford J, Mylonakis E, Ruvkun G. Author Correction: Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans. Nature Cell Biology. PMID 35411089 DOI: 10.1038/s41556-022-00868-1 |
0.227 |
|
| 2022 |
Snoozy J, Breen PC, Ruvkun G, Warnhoff K. /MOCS2A is necessary for molybdenum cofactor synthesis in . Micropublication Biology. 2022. PMID 35224462 DOI: 10.17912/micropub.biology.000531 |
0.371 |
|
| 2021 |
Charlesworth AG, Seroussi U, Lehrbach NJ, Renaud MS, Sundby AE, Molnar RI, Lao RX, Willis AR, Woock JR, Aber MJ, Diao AJ, Reinke AW, Ruvkun G, Claycomb JM. Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility. Nucleic Acids Research. PMID 34329465 DOI: 10.1093/nar/gkab619 |
0.722 |
|
| 2021 |
Warnhoff K, Hercher TW, Mendel RR, Ruvkun G. Protein-bound molybdenum cofactor is bioavailable and rescues molybdenum cofactor-deficient . Genes & Development. 35: 212-217. PMID 33446569 DOI: 10.1101/gad.345579.120 |
0.324 |
|
| 2020 |
Carr CE, Bryan NC, Saboda KN, Bhattaru SA, Ruvkun G, Zuber MT. Nanopore sequencing at Mars, Europa, and microgravity conditions. Npj Microgravity. 6: 24. PMID 34489469 DOI: 10.1038/s41526-020-00113-9 |
0.25 |
|
| 2020 |
Bryan NC, Lebreton F, Gilmore M, Ruvkun G, Zuber MT, Carr CE. Genomic and Functional Characterization of Isolates Recovered From the International Space Station and Their Potential for Pathogenicity. Frontiers in Microbiology. 11: 515319. PMID 33505359 DOI: 10.3389/fmicb.2020.515319 |
0.294 |
|
| 2020 |
Mao K, Breen P, Ruvkun G. Mitochondrial dysfunction induces RNA interference in C. elegans through a pathway homologous to the mammalian RIG-I antiviral response. Plos Biology. 18: e3000996. PMID 33264285 DOI: 10.1371/journal.pbio.3000996 |
0.349 |
|
| 2020 |
Carr CE, Bryan NC, Saboda KN, Bhattaru SA, Ruvkun G, Zuber MT. Nanopore sequencing at Mars, Europa, and microgravity conditions. Npj Microgravity. 6: 24. PMID 32964110 DOI: 10.1038/s41526-020-00113-9 |
0.257 |
|
| 2020 |
Wei W, Ruvkun G. Lysosomal activity regulates mitochondrial dynamics through vitamin B12 metabolism. Proceedings of the National Academy of Sciences of the United States of America. PMID 32737159 DOI: 10.1073/Pnas.2008021117 |
0.38 |
|
| 2020 |
Fischer SEJ, Ruvkun G. ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons. Proceedings of the National Academy of Sciences of the United States of America. 117: 5987-5996. PMID 32123111 DOI: 10.1073/Pnas.1919028117 |
0.49 |
|
| 2019 |
Govindan JA, Jayamani E, Ruvkun G. ROS-based lethality of mitochondrial electron transport mutants grown on siderophore iron release mutants. Proceedings of the National Academy of Sciences of the United States of America. PMID 31591219 DOI: 10.1073/Pnas.1912628116 |
0.392 |
|
| 2019 |
Mojarro A, Hachey J, Bailey R, Brown M, Doebler R, Ruvkun G, Zuber MT, Carr CE. Nucleic Acid Extraction and Sequencing from Low-Biomass Synthetic Mars Analog Soils for Life Detection. Astrobiology. PMID 31204862 DOI: 10.1089/Ast.2018.1929 |
0.38 |
|
| 2019 |
Armakola M, Ruvkun G. Regulation of neuronal polarity by heterochronic genes. Proceedings of the National Academy of Sciences of the United States of America. PMID 31164416 DOI: 10.1073/Pnas.1820928116 |
0.473 |
|
| 2019 |
Ast T, Meisel JD, Patra S, Wang H, Grange RMH, Kim SH, Calvo SE, Orefice LL, Nagashima F, Ichinose F, Zapol WM, Ruvkun G, Barondeau DP, Mootha VK. Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis. Cell. PMID 31031004 DOI: 10.1016/J.Cell.2019.03.045 |
0.364 |
|
| 2019 |
Lehrbach NJ, Breen PC, Ruvkun G. Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression. Cell. 177: 737-750.e15. PMID 31002798 DOI: 10.1016/J.Cell.2019.03.035 |
0.421 |
|
| 2019 |
Lehrbach NJ, Ruvkun G. Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity. Elife. 8. PMID 30973820 DOI: 10.7554/Elife.44425 |
0.38 |
|
| 2019 |
Warnhoff K, Ruvkun G. Molybdenum cofactor transfer from bacteria to nematode mediates sulfite detoxification. Nature Chemical Biology. PMID 30911177 DOI: 10.1038/S41589-019-0249-Y |
0.495 |
|
| 2019 |
Kniazeva M, Ruvkun G. induces DNA damage in intestinal cells. Proceedings of the National Academy of Sciences of the United States of America. 116: 3784-3792. PMID 30808764 DOI: 10.1073/Pnas.1815656116 |
0.402 |
|
| 2019 |
Mao K, Ji F, Breen P, Sewell A, Han M, Sadreyev R, Ruvkun G. Mitochondrial Dysfunction in C. elegans Activates Mitochondrial Relocalization and Nuclear Hormone Receptor-Dependent Detoxification Genes. Cell Metabolism. PMID 30799287 DOI: 10.1016/J.Cmet.2019.01.022 |
0.384 |
|
| 2019 |
Lehrbach NJ, Ruvkun G. Author response: Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity Elife. DOI: 10.7554/Elife.44425.021 |
0.349 |
|
| 2018 |
Lin XX, Sen I, Janssens GE, Zhou X, Fonslow BR, Edgar D, Stroustrup N, Swoboda P, Yates JR, Ruvkun G, Riedel CG. DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity. Nature Communications. 9: 4400. PMID 30353013 DOI: 10.1038/S41467-018-06624-0 |
0.464 |
|
| 2018 |
Tillman EJ, Richardson CE, Cattie DJ, Reddy KC, Lehrbach NJ, Droste R, Ruvkun G, Kim DH. Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of . Genetics. PMID 30287474 DOI: 10.1534/Genetics.118.301450 |
0.62 |
|
| 2018 |
Carr CE, Bryan NC, Saboda KN, Bhattaru SA, Ruvkun G, Zuber MT. Acceleration profiles and processing methods for parabolic flight. Npj Microgravity. 4: 14. PMID 30109261 DOI: 10.1038/S41526-018-0050-3 |
0.331 |
|
| 2018 |
Pontefract A, Hachey J, Zuber MT, Ruvkun G, Carr CE. Sequencing nothing: Exploring failure modes of nanopore sensing and implications for life detection. Life Sciences in Space Research. 18: 80-86. PMID 30100151 DOI: 10.1016/J.Lssr.2018.05.004 |
0.371 |
|
| 2018 |
Ambros V, Ruvkun G. Recent Molecular Genetic Explorations of MicroRNAs. Genetics. 209: 651-673. PMID 29967059 DOI: 10.1534/Genetics.118.300291 |
0.699 |
|
| 2018 |
Newman MA, Ji F, Fischer SEJ, Anselmo A, Sadreyev RI, Ruvkun G. The surveillance of pre-mRNA splicing is an early step in RNAi of endogenous genes. Genes & Development. PMID 29739806 DOI: 10.1101/Gad.311514.118 |
0.53 |
|
| 2018 |
Mojarro A, Hachey J, Ruvkun G, Zuber MT, Carr CE. CarrierSeq: a sequence analysis workflow for low-input nanopore sequencing. Bmc Bioinformatics. 19: 108. PMID 29587645 DOI: 10.1186/S12859-018-2124-3 |
0.351 |
|
| 2017 |
Pontefract A, Zhu TF, Walker VK, Hepburn H, Lui C, Zuber MT, Ruvkun G, Carr CE. Microbial Diversity in a Hypersaline Sulfate Lake: A Terrestrial Analog of Ancient Mars. Frontiers in Microbiology. 8: 1819. PMID 29018418 DOI: 10.3389/Fmicb.2017.01819 |
0.346 |
|
| 2017 |
Mojarro A, Ruvkun G, Zuber MT, Carr CE. Nucleic Acid Extraction from Synthetic Mars Analog Soils for in situ Life Detection. Astrobiology. PMID 28704064 DOI: 10.1089/Ast.2016.1535 |
0.35 |
|
| 2016 |
Lehrbach NJ, Ruvkun G. Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1. Elife. 5. PMID 27528192 DOI: 10.7554/Elife.17721 |
0.469 |
|
| 2016 |
Dowen RH, Breen PC, Tullius T, Conery AL, Ruvkun G. A microRNA program in the C. elegans hypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport. Genes & Development. 30: 1515-28. PMID 27401555 DOI: 10.1101/Gad.283895.116 |
0.444 |
|
| 2016 |
Samuel BS, Rowedder H, Braendle C, Félix MA, Ruvkun G. Caenorhabditis elegans responses to bacteria from its natural habitats. Proceedings of the National Academy of Sciences of the United States of America. PMID 27317746 DOI: 10.1073/Pnas.1607183113 |
0.723 |
|
| 2016 |
Rettberg P, Anesio AM, Baker VR, Baross JA, Cady SL, Detsis E, Foreman CM, Hauber E, Ori GG, Pearce DA, Renno NO, Ruvkun G, Sattler B, Saunders MP, Smith DH, et al. Planetary Protection and Mars Special Regions-A Suggestion for Updating the Definition. Astrobiology. PMID 26848950 DOI: 10.1089/Ast.2016.1472 |
0.328 |
|
| 2016 |
Lehrbach NJ, Ruvkun G. Author response: Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1 Elife. DOI: 10.7554/Elife.17721.016 |
0.318 |
|
| 2016 |
Carr CE, Mojarro A, Tani J, Bhattaru SA, Zuber MT, Doebler R, Brown M, Herrington K, Talbot R, Fuller CW, Finney M, Church G, Ruvkun G. Advancing the search for extra-terrestrial genomes Ieee Aerospace Conference Proceedings. 2016. DOI: 10.1109/AERO.2016.7500859 |
0.441 |
|
| 2015 |
Govindan JA, Jayamani E, Zhang X, Mylonakis E, Ruvkun G. Dialogue between E. coli free radical pathways and the mitochondria of C. elegans. Proceedings of the National Academy of Sciences of the United States of America. PMID 26392561 DOI: 10.1073/Pnas.1517448112 |
0.423 |
|
| 2015 |
Govindan JA, Jayamani E, Zhang X, Breen P, Larkins-Ford J, Mylonakis E, Ruvkun G. Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans. Nature Cell Biology. 17: 1294-303. PMID 26322678 DOI: 10.1038/Ncb3229 |
0.512 |
|
| 2015 |
Phillips CM, Brown KC, Montgomery BE, Ruvkun G, Montgomery TA. piRNAs and piRNA-Dependent siRNAs Protect Conserved and Essential C. elegans Genes from Misrouting into the RNAi Pathway. Developmental Cell. 34: 457-65. PMID 26279487 DOI: 10.1016/J.Devcel.2015.07.009 |
0.735 |
|
| 2015 |
Sadreyev IR, Ji F, Cohen E, Ruvkun G, Tabach Y. PhyloGene server for identification and visualization of co-evolving proteins using normalized phylogenetic profiles. Nucleic Acids Research. 43: W154-9. PMID 25958392 DOI: 10.1093/Nar/Gkv452 |
0.425 |
|
| 2015 |
Kirienko NV, Ausubel FM, Ruvkun G. Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences of the United States of America. 112: 1821-6. PMID 25624506 DOI: 10.1073/Pnas.1424954112 |
0.73 |
|
| 2015 |
O'Rourke EJ, Ruvkun G. Corrigendum: MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability Nature Cell Biology. 17: 104-104. DOI: 10.1038/Ncb3085 |
0.342 |
|
| 2014 |
Govindan JA, Ruvkun G. Pathogens. Virulence. 5: 695-6. PMID 25513769 DOI: 10.4161/viru.36667 |
0.225 |
|
| 2014 |
Wang MC, Oakley HD, Carr CE, Sowa JN, Ruvkun G. Gene pathways that delay Caenorhabditis elegans reproductive senescence. Plos Genetics. 10: e1004752. PMID 25474471 DOI: 10.1371/Journal.Pgen.1004752 |
0.482 |
|
| 2014 |
Garcia SM, Tabach Y, Lourenço GF, Armakola M, Ruvkun G. Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans. Nature Structural & Molecular Biology. 21: 712-20. PMID 25038802 DOI: 10.1038/Nsmb.2858 |
0.528 |
|
| 2014 |
Liu Y, Samuel BS, Breen PC, Ruvkun G. Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature. 508: 406-10. PMID 24695221 DOI: 10.1038/Nature13204 |
0.731 |
|
| 2014 |
Phillips CM, Montgomery BE, Breen PC, Roovers EF, Rim YS, Ohsumi TK, Newman MA, van Wolfswinkel JC, Ketting RF, Ruvkun G, Montgomery TA. MUT-14 and SMUT-1 DEAD box RNA helicases have overlapping roles in germline RNAi and endogenous siRNA formation. Current Biology : Cb. 24: 839-44. PMID 24684932 DOI: 10.1016/J.Cub.2014.02.060 |
0.701 |
|
| 2013 |
Fischer SE, Pan Q, Breen PC, Qi Y, Shi Z, Zhang C, Ruvkun G. Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans. Genes & Development. 27: 2678-95. PMID 24352423 DOI: 10.1101/Gad.233254.113 |
0.646 |
|
| 2013 |
Schwartz S, Agarwala SD, Mumbach MR, Jovanovic M, Mertins P, Shishkin A, Tabach Y, Mikkelsen TS, Satija R, Ruvkun G, Carr SA, Lander ES, Fink GR, Regev A. High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Cell. 155: 1409-21. PMID 24269006 DOI: 10.1016/J.Cell.2013.10.047 |
0.385 |
|
| 2013 |
Soukas AA, Carr CE, Ruvkun G. Genetic regulation of Caenorhabditis elegans lysosome related organelle function. Plos Genetics. 9: e1003908. PMID 24204312 DOI: 10.1371/Journal.Pgen.1003908 |
0.492 |
|
| 2013 |
Tabach Y, Golan T, Hernández-Hernández A, Messer AR, Fukuda T, Kouznetsova A, Liu JG, Lilienthal I, Levy C, Ruvkun G. Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling. Molecular Systems Biology. 9: 692. PMID 24084807 DOI: 10.1038/Msb.2013.50 |
0.478 |
|
| 2013 |
Shi Z, Hayes G, Ruvkun G. Dual regulation of the lin-14 target mRNA by the lin-4 miRNA. Plos One. 8: e75475. PMID 24058689 DOI: 10.1371/Journal.Pone.0075475 |
0.776 |
|
| 2013 |
Carr CE, Rowedder H, Lui CS, Zlatkovsky I, Papalias CW, Bolander J, Myers JW, Bustillo J, Rothberg JM, Zuber MT, Ruvkun G. Radiation resistance of sequencing chips for in situ life detection. Astrobiology. 13: 560-9. PMID 23734755 DOI: 10.1089/Ast.2012.0923 |
0.371 |
|
| 2013 |
Shore DE, Ruvkun G. A cytoprotective perspective on longevity regulation. Trends in Cell Biology. 23: 409-20. PMID 23726168 DOI: 10.1016/J.Tcb.2013.04.007 |
0.416 |
|
| 2013 |
Montgomery TA, Ruvkun G. MicroRNAs visit the ER. Cell. 153: 511-2. PMID 23622236 DOI: 10.1016/J.Cell.2013.04.014 |
0.402 |
|
| 2013 |
Riedel CG, Dowen RH, Lourenco GF, Kirienko NV, Heimbucher T, West JA, Bowman SK, Kingston RE, Dillin A, Asara JM, Ruvkun G. DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Nature Cell Biology. 15: 491-501. PMID 23604319 DOI: 10.1038/Ncb2720 |
0.712 |
|
| 2013 |
O'Rourke EJ, Ruvkun G. MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nature Cell Biology. 15: 668-76. PMID 23604316 DOI: 10.1038/Ncb2741 |
0.386 |
|
| 2013 |
Kirienko NV, Kirienko DR, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM. Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis, causing a hypoxic response and death. Cell Host & Microbe. 13: 406-16. PMID 23601103 DOI: 10.1016/J.Chom.2013.03.003 |
0.727 |
|
| 2013 |
O'Rourke EJ, Kuballa P, Xavier R, Ruvkun G. ω-6 Polyunsaturated fatty acids extend life span through the activation of autophagy. Genes & Development. 27: 429-40. PMID 23392608 DOI: 10.1101/Gad.205294.112 |
0.394 |
|
| 2013 |
Tabach Y, Billi AC, Hayes GD, Newman MA, Zuk O, Gabel H, Kamath R, Yacoby K, Chapman B, Garcia SM, Borowsky M, Kim JK, Ruvkun G. Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence. Nature. 493: 694-8. PMID 23364702 DOI: 10.1038/Nature11779 |
0.803 |
|
| 2013 |
Shi Z, Montgomery TA, Qi Y, Ruvkun G. High-throughput sequencing reveals extraordinary fluidity of miRNA, piRNA, and siRNA pathways in nematodes. Genome Research. 23: 497-508. PMID 23363624 DOI: 10.1101/Gr.149112.112 |
0.583 |
|
| 2013 |
Carr CE, Rowedder H, Vafadari C, Lui CS, Cascio E, Zuber MT, Ruvkun G. Radiation resistance of biological reagents for in situ life detection. Astrobiology. 13: 68-78. PMID 23330963 DOI: 10.1089/Ast.2012.0869 |
0.363 |
|
| 2013 |
Carr CE, Zuber MT, Ruvkun G. Life detection with the Enceladus Orbiting Sequencer Ieee Aerospace Conference Proceedings. DOI: 10.1109/AERO.2013.6497129 |
0.234 |
|
| 2012 |
Tacutu R, Shore DE, Budovsky A, de Magalhães JP, Ruvkun G, Fraifeld VE, Curran SP. Prediction of C. elegans longevity genes by human and worm longevity networks. Plos One. 7: e48282. PMID 23144747 DOI: 10.1371/Journal.Pone.0048282 |
0.485 |
|
| 2012 |
Zhang C, Ruvkun G. New insights into siRNA amplification and RNAi. Rna Biology. 9: 1045-9. PMID 22858672 DOI: 10.4161/Rna.21246 |
0.493 |
|
| 2012 |
Shore DE, Carr CE, Ruvkun G. Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways. Plos Genetics. 8: e1002792. PMID 22829775 DOI: 10.1371/journal.pgen.1002792 |
0.413 |
|
| 2012 |
Phillips CM, Montgomery TA, Breen PC, Ruvkun G. MUT-16 promotes formation of perinuclear mutator foci required for RNA silencing in the C. elegans germline. Genes & Development. 26: 1433-44. PMID 22713602 DOI: 10.1101/Gad.193904.112 |
0.7 |
|
| 2012 |
Zhang C, Montgomery TA, Fischer SE, Garcia SM, Riedel CG, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G. The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification. Current Biology : Cb. 22: 881-90. PMID 22542102 DOI: 10.1016/J.Cub.2012.04.011 |
0.539 |
|
| 2012 |
Montgomery TA, Rim YS, Zhang C, Dowen RH, Phillips CM, Fischer SE, Ruvkun G. PIWI associated siRNAs and piRNAs specifically require the Caenorhabditis elegans HEN1 ortholog henn-1. Plos Genetics. 8: e1002616. PMID 22536158 DOI: 10.1371/Journal.Pgen.1002616 |
0.685 |
|
| 2012 |
Wählby C, Kamentsky L, Liu ZH, Riklin-Raviv T, Conery AL, O'Rourke EJ, Sokolnicki KL, Visvikis O, Ljosa V, Irazoqui JE, Golland P, Ruvkun G, Ausubel FM, Carpenter AE. An image analysis toolbox for high-throughput C. elegans assays. Nature Methods. 9: 714-6. PMID 22522656 DOI: 10.1038/Nmeth.1984 |
0.731 |
|
| 2012 |
Melo JA, Ruvkun G. Inactivation of conserved C. elegans genes engages pathogen- and xenobiotic-associated defenses. Cell. 149: 452-66. PMID 22500807 DOI: 10.1016/J.Cell.2012.02.050 |
0.724 |
|
| 2012 |
Wu X, Shi Z, Cui M, Han M, Ruvkun G. Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes. Plos Genetics. 8: e1002542. PMID 22412383 DOI: 10.1371/Journal.Pgen.1002542 |
0.571 |
|
| 2012 |
Shi Z, Ruvkun G. The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 109: 4568-73. PMID 22396595 DOI: 10.1073/Pnas.1202421109 |
0.556 |
|
| 2011 |
Kimura KD, Riddle DL, Ruvkun G. The C. elegans DAF-2 insulin-like receptor is abundantly expressed in the nervous system and regulated by nutritional status. Cold Spring Harbor Symposia On Quantitative Biology. 76: 113-20. PMID 22123849 DOI: 10.1101/Sqb.2011.76.010660 |
0.72 |
|
| 2011 |
Fischer SE, Montgomery TA, Zhang C, Fahlgren N, Breen PC, Hwang A, Sullivan CM, Carrington JC, Ruvkun G. The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications. Plos Genetics. 7: e1002369. PMID 22102828 DOI: 10.1371/Journal.Pgen.1002369 |
0.55 |
|
| 2011 |
Russel S, Frand AR, Ruvkun G. Regulation of the C. elegans molt by pqn-47. Developmental Biology. 360: 297-309. PMID 21989027 DOI: 10.1016/J.Ydbio.2011.09.025 |
0.8 |
|
| 2011 |
Hayes GD, Riedel CG, Ruvkun G. The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA. Genes & Development. 25: 2079-92. PMID 21979920 DOI: 10.1101/Gad.17153811 |
0.758 |
|
| 2011 |
Zhang C, Montgomery TA, Gabel HW, Fischer SE, Phillips CM, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G. mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 108: 1201-8. PMID 21245313 DOI: 10.1073/Pnas.1018695108 |
0.816 |
|
| 2011 |
Wang MC, Min W, Freudiger CW, Ruvkun G, Xie XS. RNAi screening for fat regulatory genes with SRS microscopy. Nature Methods. 8: 135-8. PMID 21240281 DOI: 10.1038/Nmeth.1556 |
0.446 |
|
| 2011 |
Lui C, Carr CE, Rowedder H, Ruvkun G, Zuber M. SETG: An instrument for detection of life on Mars ancestrally related to life on Earth Ieee Aerospace Conference Proceedings. DOI: 10.1109/AERO.2011.5747299 |
0.216 |
|
| 2010 |
Wu X, Ruvkun G. Cancer. Germ cell genes and cancer. Science (New York, N.Y.). 330: 1761-2. PMID 21205660 DOI: 10.1126/Science.1200772 |
0.412 |
|
| 2010 |
Meli VS, Osuna B, Ruvkun G, Frand AR. MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans. Molecular Biology of the Cell. 21: 1648-61. PMID 20335506 DOI: 10.1091/Mbc.E08-07-0708 |
0.475 |
|
| 2010 |
Kabra M, Conery AL, O’Rourke EJ, Xie X, Ljosa V, Jones TR, Ausubel FM, Ruvkun G, Carpenter AE, Freund Y. Towards automated high-throughput screening of C. elegans on agar F1000research. 1. DOI: 10.7490/F1000Research.252.1 |
0.538 |
|
| 2009 |
Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SE, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, ... ... Ruvkun G, et al. RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. Plos One. 4: e8210. PMID 20011587 DOI: 10.1371/Journal.Pone.0008210 |
0.511 |
|
| 2009 |
O'Rourke EJ, Soukas AA, Carr CE, Ruvkun G. C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metabolism. 10: 430-5. PMID 19883620 DOI: 10.1016/J.Cmet.2009.10.002 |
0.415 |
|
| 2009 |
Curran SP, Wu X, Riedel CG, Ruvkun G. A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature. 459: 1079-84. PMID 19506556 DOI: 10.1038/Nature08106 |
0.489 |
|
| 2009 |
Soukas AA, Kane EA, Carr CE, Melo JA, Ruvkun G. Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes & Development. 23: 496-511. PMID 19240135 DOI: 10.1101/Gad.1775409 |
0.708 |
|
| 2009 |
Butcher RA, Ragains JR, Li W, Ruvkun G, Clardy J, Mak HY. Biosynthesis of the Caenorhabditis elegans dauer pheromone. Proceedings of the National Academy of Sciences of the United States of America. 106: 1875-9. PMID 19174521 DOI: 10.1073/Pnas.0810338106 |
0.377 |
|
| 2009 |
Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SEJ, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, ... ... Ruvkun G, et al. Correction: RNA Editing Genes Associated with Extreme Old Age in Humans and with Lifespan in C. elegans Plos One. 4. DOI: 10.1371/Annotation/387F8074-5F80-4Bdd-Bb0B-B36D49A16Ac0 |
0.436 |
|
| 2008 |
Wang MC, O'Rourke EJ, Ruvkun G. Fat metabolism links germline stem cells and longevity in C. elegans. Science (New York, N.Y.). 322: 957-60. PMID 18988854 DOI: 10.1126/Science.1162011 |
0.398 |
|
| 2008 |
Isenbarger TA, Carr CE, Johnson SS, Finney M, Church GM, Gilbert W, Zuber MT, Ruvkun G. The most conserved genome segments for life detection on Earth and other planets. Origins of Life and Evolution of the Biosphere : the Journal of the International Society For the Study of the Origin of Life. 38: 517-33. PMID 18853276 DOI: 10.1007/S11084-008-9148-Z |
0.789 |
|
| 2008 |
Ruvkun G. The perfect storm of tiny RNAs. Nature Medicine. 14: 1041-5. PMID 18841145 DOI: 10.1038/Nm1008-1041 |
0.406 |
|
| 2008 |
Fischer SE, Butler MD, Pan Q, Ruvkun G. Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7. Nature. 455: 491-6. PMID 18784652 DOI: 10.1038/Nature07274 |
0.772 |
|
| 2008 |
Ruvkun G. Tiny RNA: Where do we come from? What are we? Where are we going? Trends in Plant Science. 13: 313-6. PMID 18562240 DOI: 10.1016/J.Tplants.2008.05.005 |
0.44 |
|
| 2008 |
Simon DJ, Madison JM, Conery AL, Thompson-Peer KL, Soskis M, Ruvkun GB, Kaplan JM, Kim JK. The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions. Cell. 133: 903-15. PMID 18510933 DOI: 10.1016/J.Cell.2008.04.035 |
0.498 |
|
| 2008 |
Patel DS, Fang LL, Svy DK, Ruvkun G, Li W. Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans. Development (Cambridge, England). 135: 2239-49. PMID 18495818 DOI: 10.1242/Dev.016972 |
0.437 |
|
| 2008 |
Gabel HW, Ruvkun G. The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi. Nature Structural & Molecular Biology. 15: 531-3. PMID 18438419 DOI: 10.1038/Nsmb.1411 |
0.733 |
|
| 2008 |
Pierce ML, Weston MD, Fritzsch B, Gabel HW, Ruvkun G, Soukup GA. MicroRNA-183 family conservation and ciliated neurosensory organ expression. Evolution & Development. 10: 106-13. PMID 18184361 DOI: 10.1111/J.1525-142X.2007.00217.X |
0.717 |
|
| 2008 |
Isenbarger TA, Finney M, RÃos-Velázquez C, Handelsman J, Ruvkun G. Miniprimer PCR, a new lens for viewing the microbial world. Applied and Environmental Microbiology. 74: 840-9. PMID 18083877 DOI: 10.1128/Aem.01933-07 |
0.776 |
|
| 2007 |
Samuelson AV, Klimczak RR, Thompson DB, Carr CE, Ruvkun G. Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains. Cold Spring Harbor Symposia On Quantitative Biology. 72: 489-97. PMID 18419309 DOI: 10.1101/Sqb.2007.72.068 |
0.484 |
|
| 2007 |
Parry DH, Xu J, Ruvkun G. A whole-genome RNAi Screen for C. elegans miRNA pathway genes. Current Biology : Cb. 17: 2013-22. PMID 18023351 DOI: 10.1016/J.Cub.2007.10.058 |
0.449 |
|
| 2007 |
Samuelson AV, Carr CE, Ruvkun G. Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Genes & Development. 21: 2976-94. PMID 18006689 DOI: 10.1101/Gad.1588907 |
0.509 |
|
| 2007 |
Kim N, Dempsey CM, Kuan CJ, Zoval JV, O'Rourke E, Ruvkun G, Madou MJ, Sze JY. Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in Caenorhabditis elegans. Genetics. 177: 835-45. PMID 17720915 DOI: 10.1534/Genetics.107.076901 |
0.408 |
|
| 2007 |
Curran SP, Ruvkun G. Lifespan regulation by evolutionarily conserved genes essential for viability. Plos Genetics. 3: e56. PMID 17411345 DOI: 10.1371/Journal.Pgen.0030056 |
0.458 |
|
| 2007 |
Ruvinsky I, Ohler U, Burge CB, Ruvkun G. Detection of broadly expressed neuronal genes in C. elegans. Developmental Biology. 302: 617-26. PMID 17046742 DOI: 10.1016/J.Ydbio.2006.09.014 |
0.724 |
|
| 2006 |
Hayes GD, Ruvkun G. Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs. Cold Spring Harbor Symposia On Quantitative Biology. 71: 21-7. PMID 17381276 DOI: 10.1101/Sqb.2006.71.018 |
0.781 |
|
| 2006 |
Hayes GD, Frand AR, Ruvkun G. The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25. Development (Cambridge, England). 133: 4631-41. PMID 17065234 DOI: 10.1242/Dev.02655 |
0.76 |
|
| 2006 |
Hu PJ, Xu J, Ruvkun G. Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. Plos Genetics. 2: e99. PMID 16839187 DOI: 10.1371/journal.pgen.0020099 |
0.389 |
|
| 2006 |
Sandoval GM, Duerr JS, Hodgkin J, Rand JB, Ruvkun G. A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans. Nature Neuroscience. 9: 599-601. PMID 16604067 DOI: 10.1038/Nn1685 |
0.764 |
|
| 2006 |
Mak HY, Nelson LS, Basson M, Johnson CD, Ruvkun G. Polygenic control of Caenorhabditis elegans fat storage. Nature Genetics. 38: 363-8. PMID 16462744 DOI: 10.1038/Ng1739 |
0.426 |
|
| 2006 |
Duchaine TF, Wohlschlegel JA, Kennedy S, Bei Y, Conte D, Pang K, Brownell DR, Harding S, Mitani S, Ruvkun G, Yates JR, Mello CC. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell. 124: 343-54. PMID 16439208 DOI: 10.1016/J.Cell.2005.11.036 |
0.736 |
|
| 2006 |
Ruvkun G. Clarifications on miRNA and cancer. Science (New York, N.Y.). 311: 36-7. PMID 16400132 DOI: 10.1126/Science.311.5757.36D |
0.442 |
|
| 2005 |
Frand AR, Russel S, Ruvkun G. Functional genomic analysis of C. elegans molting. Plos Biology. 3: e312. PMID 16122351 DOI: 10.1371/Journal.Pbio.0030312 |
0.806 |
|
| 2005 |
Wang D, Kennedy S, Conte D, Kim JK, Gabel HW, Kamath RS, Mello CC, Ruvkun G. Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Nature. 436: 593-7. PMID 16049496 DOI: 10.1038/Nature04010 |
0.81 |
|
| 2005 |
Sieburth D, Ch'ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, Dupuy D, Rual JF, Hill DE, Vidal M, Ruvkun G, Kaplan JM. Systematic analysis of genes required for synapse structure and function. Nature. 436: 510-7. PMID 16049479 DOI: 10.1038/Nature03809 |
0.804 |
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| 2005 |
Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, Lee SS. A systematic RNAi screen for longevity genes in C. elegans. Genes & Development. 19: 1544-55. PMID 15998808 DOI: 10.1101/Gad.1308205 |
0.55 |
|
| 2005 |
Efimenko E, Bubb K, Mak HY, Holzman T, Leroux MR, Ruvkun G, Thomas JH, Swoboda P. Analysis of xbx genes in C. elegans. Development (Cambridge, England). 132: 1923-34. PMID 15790967 DOI: 10.1242/Dev.01775 |
0.51 |
|
| 2005 |
Kim JK, Gabel HW, Kamath RS, Tewari M, Pasquinelli A, Rual JF, Kennedy S, Dybbs M, Bertin N, Kaplan JM, Vidal M, Ruvkun G. Functional genomic analysis of RNA interference in C. elegans. Science (New York, N.Y.). 308: 1164-7. PMID 15790806 DOI: 10.1126/Science.1109267 |
0.817 |
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| 2004 |
Wang D, Ruvkun G. Regulation of Caenorhabditis elegans RNA interference by the daf-2 insulin stress and longevity signaling pathway. Cold Spring Harbor Symposia On Quantitative Biology. 69: 429-31. PMID 16117677 DOI: 10.1101/Sqb.2004.69.429 |
0.597 |
|
| 2004 |
Mansfield JH, Harfe BD, Nissen R, Obenauer J, Srineel J, Chaudhuri A, Farzan-Kashani R, Zuker M, Pasquinelli AE, Ruvkun G, Sharp PA, Tabin CJ, McManus MT. MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nature Genetics. 36: 1079-83. PMID 15361871 DOI: 10.1038/Ng1421 |
0.428 |
|
| 2004 |
Mak HY, Ruvkun G. Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450. Development (Cambridge, England). 131: 1777-86. PMID 15084462 DOI: 10.1242/Dev.01069 |
0.489 |
|
| 2004 |
Ruvkun G, Wightman B, Ha I. The 20 years it took to recognize the importance of tiny RNAs. Cell. 116: S93-6, 2 p following. PMID 15055593 DOI: 10.1016/S0092-8674(04)00034-0 |
0.403 |
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| 2004 |
Bolm M, Chhatwal GS, Jansen WTM, Ausubel FM, Begun J, Kim DH, Moy T, Ruvkun G, Calderwood SB, Sifri CD, Garsin DA. Bacterial Resistance of daf-2 Mutants [2] (multiple letters) Science. 303: 1976. PMID 15044786 |
0.628 |
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| 2004 |
Bolm M, Chhatwal GS, Jansen WTM, Ausubel FM, Begun J, Kim DH, Moy T, Ruvkun G, Calderwood SB, Sifri CD, Garsin DA. Bacterial Resistance of daf-2 Mutants [2] (multiple letters) Science. 303: 1976. PMID 15044786 |
0.254 |
|
| 2004 |
Tewari M, Hu PJ, Ahn JS, Ayivi-Guedehoussou N, Vidalain PO, Li S, Milstein S, Armstrong CM, Boxem M, Butler MD, Busiguina S, Rual JF, Ibarrola N, Chaklos ST, Bertin N, ... ... Ruvkun G, et al. Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network. Molecular Cell. 13: 469-82. PMID 14992718 DOI: 10.1016/S1097-2765(04)00033-4 |
0.719 |
|
| 2004 |
Kennedy S, Wang D, Ruvkun G. A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature. 427: 645-9. PMID 14961122 DOI: 10.1038/Nature02302 |
0.773 |
|
| 2004 |
Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proceedings of the National Academy of Sciences of the United States of America. 101: 360-5. PMID 14691248 DOI: 10.1073/Pnas.2333854100 |
0.777 |
|
| 2004 |
Ruvkun G. Breaking the silence Nature Genetics. 36: 435-435. DOI: 10.1038/Ng0504-435 |
0.397 |
|
| 2004 |
Ruvkun G. DNA approach to Mars New Scientist. 181: 19. |
0.199 |
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| 2004 |
Ruvkun G. DNA approach to Mars New Scientist. 181: 19. |
0.199 |
|
| 2003 |
Ruvkun GB. The tiny RNA world. Harvey Lectures. 99: 1-21. PMID 15984549 |
0.305 |
|
| 2003 |
Komaroff AL, Ruvkun G. Unraveling the secrets of the cell. Newsweek. 142: 96. PMID 14712576 |
0.225 |
|
| 2003 |
Ruvinsky I, Ruvkun G. Functional tests of enhancer conservation between distantly related species. Development (Cambridge, England). 130: 5133-42. PMID 12944426 DOI: 10.1242/Dev.00711 |
0.737 |
|
| 2003 |
Sze JY, Ruvkun G. Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity. Proceedings of the National Academy of Sciences of the United States of America. 100: 9560-5. PMID 12883006 DOI: 10.1073/Pnas.1530752100 |
0.417 |
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| 2003 |
Pasquinelli AE, McCoy A, Jiménez E, Saló E, Ruvkun G, Martindale MQ, Baguñà J. Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: a role in life history evolution? Evolution & Development. 5: 372-8. PMID 12823453 DOI: 10.1046/J.1525-142X.2003.03044.X |
0.44 |
|
| 2003 |
Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, Ausubel FM. Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science (New York, N.Y.). 300: 1921. PMID 12817143 DOI: 10.1126/Science.1080147 |
0.773 |
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| 2003 |
Bashirullah A, Pasquinelli AE, Kiger AA, Perrimon N, Ruvkun G, Thummel CS. Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Developmental Biology. 259: 1-8. PMID 12812783 DOI: 10.1016/S0012-1606(03)00063-0 |
0.437 |
|
| 2003 |
Aspöck G, Ruvkun G, Bürglin TR. The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function. Development (Cambridge, England). 130: 3369-78. PMID 12810585 DOI: 10.1242/Dev.00551 |
0.46 |
|
| 2003 |
Grad Y, Aach J, Hayes GD, Reinhart BJ, Church GM, Ruvkun G, Kim J. Computational and experimental identification of C. elegans microRNAs. Molecular Cell. 11: 1253-63. PMID 12769849 DOI: 10.1016/S1097-2765(03)00153-9 |
0.782 |
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| 2003 |
Lee SS, Kennedy S, Tolonen AC, Ruvkun G. DAF-16 target genes that control C. elegans life-span and metabolism. Science (New York, N.Y.). 300: 644-7. PMID 12690206 DOI: 10.1126/Science.1083614 |
0.742 |
|
| 2003 |
Li W, Kennedy SG, Ruvkun G. daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway. Genes & Development. 17: 844-58. PMID 12654727 DOI: 10.1101/Gad.1066503 |
0.709 |
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| 2003 |
Ambros V, Bartel B, Bartel DP, Burge CB, Carrington JC, Chen X, Dreyfuss G, Eddy SR, Griffiths-Jones S, Marshall M, Matzke M, Ruvkun G, Tuschl T. A uniform system for microRNA annotation. Rna (New York, N.Y.). 9: 277-9. PMID 12592000 DOI: 10.1261/Rna.2183803 |
0.644 |
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| 2003 |
Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, Ahringer J, Ruvkun G. Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature. 421: 268-72. PMID 12529643 DOI: 10.1038/Nature01279 |
0.689 |
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| 2003 |
Lee SS, Lee RY, Fraser AG, Kamath RS, Ahringer J, Ruvkun G. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nature Genetics. 33: 40-8. PMID 12447374 DOI: 10.1038/Ng1056 |
0.485 |
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| 2002 |
Wolkow CA, Muñoz MJ, Riddle DL, Ruvkun G. Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway. The Journal of Biological Chemistry. 277: 49591-7. PMID 12393910 DOI: 10.1074/Jbc.M207866200 |
0.429 |
|
| 2002 |
Pasquinelli AE, Ruvkun G. Control of developmental timing by micrornas and their targets. Annual Review of Cell and Developmental Biology. 18: 495-513. PMID 12142272 DOI: 10.1146/Annurev.Cellbio.18.012502.105832 |
0.546 |
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| 2002 |
Sze JY, Zhang S, Li J, Ruvkun G. The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons. Development (Cambridge, England). 129: 3901-11. PMID 12135927 |
0.337 |
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| 2002 |
Lee SS, Ruvkun G. Longevity: don't hold your breath. Nature. 418: 287-8. PMID 12124610 DOI: 10.1038/418287A |
0.334 |
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| 2001 |
Lee RY, Hench J, Ruvkun G. Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Current Biology : Cb. 11: 1950-7. PMID 11747821 DOI: 10.1016/S0960-9822(01)00595-4 |
0.429 |
|
| 2001 |
Finch CE, Ruvkun G. The genetics of aging. Annual Review of Genomics and Human Genetics. 2: 435-62. PMID 11701657 DOI: 10.1146/Annurev.Genom.2.1.435 |
0.456 |
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| 2001 |
Ruvkun G. Molecular biology. Glimpses of a tiny RNA world. Science (New York, N.Y.). 294: 797-9. PMID 11679654 DOI: 10.1126/Science.1066315 |
0.442 |
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| 2001 |
Grishok A, Pasquinelli AE, Conte D, Li N, Parrish S, Ha I, Baillie DL, Fire A, Ruvkun G, Mello CC. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell. 106: 23-34. PMID 11461699 DOI: 10.1016/S0092-8674(01)00431-7 |
0.692 |
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| 2001 |
Pierce SB, Costa M, Wisotzkey R, Devadhar S, Homburger SA, Buchman AR, Ferguson KC, Heller J, Platt DM, Pasquinelli AA, Liu LX, Doberstein SK, Ruvkun G. Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes & Development. 15: 672-86. PMID 11274053 DOI: 10.1101/Gad.867301 |
0.445 |
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| 2001 |
Bürglin TR, Ruvkun G. Regulation of ectodermal and excretory function by the C. elegans POU homeobox gene ceh-6. Development (Cambridge, England). 128: 779-90. PMID 11171402 |
0.425 |
|
| 2001 |
Reinhart BJ, Ruvkun G. Isoform-specific mutations in the Caenorhabditis elegans heterochronic gene lin-14 affect stage-specific patterning. Genetics. 157: 199-209. PMID 11139502 |
0.317 |
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| 2001 |
Cahill CM, Tzivion G, Nasrin N, Ogg S, Dore J, Ruvkun G, Alexander-Bridges M. Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways. The Journal of Biological Chemistry. 276: 13402-10. PMID 11124266 DOI: 10.1074/Jbc.M010042200 |
0.408 |
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| 2000 |
Kagoshima H, Sommer R, Reinhart BJ, Cassata G, Ruvkun G, Bürglin TR. Graded expression of ceh-14 reporters in the hypodermis is induced by a gonadal signal. Development Genes and Evolution. 210: 564-9. PMID 11180807 DOI: 10.1007/S004270000099 |
0.446 |
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| 2000 |
Pasquinelli AE, Reinhart BJ, Slack F, Martindale MQ, Kuroda MI, Maller B, Hayward DC, Ball EE, Degnan B, Müller P, Spring J, Srinivasan A, Fishman M, Finnerty J, Corbo J, ... ... Ruvkun G, et al. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature. 408: 86-9. PMID 11081512 DOI: 10.1038/35040556 |
0.638 |
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| 2000 |
Wolkow CA, Kimura KD, Lee MS, Ruvkun G. Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science (New York, N.Y.). 290: 147-50. PMID 11021802 DOI: 10.1126/Science.290.5489.147 |
0.724 |
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| 2000 |
Nasrin N, Ogg S, Cahill CM, Biggs W, Nui S, Dore J, Calvo D, Shi Y, Ruvkun G, Alexander-Bridges MC. DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells. Proceedings of the National Academy of Sciences of the United States of America. 97: 10412-7. PMID 10973497 DOI: 10.1073/Pnas.190326997 |
0.424 |
|
| 2000 |
Slack FJ, Basson M, Liu Z, Ambros V, Horvitz HR, Ruvkun G. The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Molecular Cell. 5: 659-69. PMID 10882102 DOI: 10.1016/S1097-2765(00)80245-2 |
0.826 |
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| 2000 |
Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 403: 901-6. PMID 10706289 DOI: 10.1038/35002607 |
0.791 |
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| 2000 |
Sze JY, Victor M, Loer C, Shi Y, Ruvkun G. Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant. Nature. 403: 560-4. PMID 10676966 DOI: 10.1038/35000609 |
0.429 |
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| 2000 |
Tissenbaum HA, Hawdon J, Perregaux M, Hotez P, Guarente L, Ruvkun G. A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum. Proceedings of the National Academy of Sciences of the United States of America. 97: 460-5. PMID 10618440 DOI: 10.1073/Pnas.97.1.460 |
0.415 |
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| 2000 |
Ruvkun G. ABSTRACT The taxonomy of animal developmental controlgenes revealed by the first complete animal genome sequence Biochemistry and Cell Biology. 78: 650. DOI: 10.1139/O00-048 |
0.265 |
|
| 1999 |
Davidson EH, Ruvkun G. Themes from a NASA workshop on gene regulatory processes in development and evolution. The Journal of Experimental Zoology. 285: 104-15. PMID 10440721 DOI: 10.1002/(Sici)1097-010X(19990815)285:2<104::Aid-Jez2>3.0.Co;2-Z |
0.395 |
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| 1999 |
Sagasti A, Hobert O, Troemel ER, Ruvkun G, Bargmann CI. Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4. Genes & Development. 13: 1794-806. PMID 10421632 DOI: 10.1101/Gad.13.14.1794 |
0.709 |
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| 1999 |
Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G. A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes & Development. 13: 1438-52. PMID 10364160 DOI: 10.1101/Gad.13.11.1438 |
0.431 |
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| 1999 |
Hobert O, Ruvkun G. Pax genes in Caenorhabditis elegans: a new twist. Trends in Genetics : Tig. 15: 214-6. PMID 10354580 DOI: 10.1016/S0168-9525(99)01731-X |
0.567 |
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| 1999 |
Hobert O, Tessmar K, Ruvkun G. The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons. Development (Cambridge, England). 126: 1547-62. PMID 10068647 |
0.606 |
|
| 1999 |
Hobert O, Moerman DG, Clark KA, Beckerle MC, Ruvkun G. A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans. The Journal of Cell Biology. 144: 45-57. PMID 9885243 DOI: 10.1083/Jcb.144.1.45 |
0.585 |
|
| 1998 |
Hobert O, Ruvkun G. A common theme for LIM homeobox gene function across phylogeny? The Biological Bulletin. 195: 377-80. PMID 9924780 DOI: 10.2307/1543153 |
0.667 |
|
| 1998 |
Slack F, Ruvkun G. Heterochronic genes in development and evolution. The Biological Bulletin. 195: 375-6. PMID 9924779 DOI: 10.2307/1543152 |
0.64 |
|
| 1998 |
Ogg S, Ruvkun G. The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Molecular Cell. 2: 887-93. PMID 9885576 DOI: 10.1016/S1097-2765(00)80303-2 |
0.431 |
|
| 1998 |
Slack FJ, Ruvkun G. A novel repeat domain that is often associated with RING finger and B-box motifs. Trends in Biochemical Sciences. 23: 474-5. PMID 9868369 DOI: 10.1016/S0968-0004(98)01299-7 |
0.529 |
|
| 1998 |
Ruvkun G, Hobert O. The taxonomy of developmental control in Caenorhabditis elegans. Science (New York, N.Y.). 282: 2033-41. PMID 9851920 DOI: 10.1126/Science.282.5396.2033 |
0.656 |
|
| 1998 |
Guarente L, Ruvkun G, Amasino R. Aging, life span, and senescence. Proceedings of the National Academy of Sciences of the United States of America. 95: 11034-6. PMID 9736682 DOI: 10.1073/Pnas.95.19.11034 |
0.35 |
|
| 1998 |
Paradis S, Ruvkun G. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes & Development. 12: 2488-98. PMID 9716402 DOI: 10.1101/Gad.12.16.2488 |
0.423 |
|
| 1998 |
Tissenbaum HA, Ruvkun G. An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. Genetics. 148: 703-17. PMID 9504918 |
0.339 |
|
| 1998 |
Hobert O, D'Alberti T, Liu Y, Ruvkun G. Control of neural development and function in a thermoregulatory network by the LIM homeobox gene lin-11. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 2084-96. PMID 9482795 DOI: 10.1523/Jneurosci.18-06-02084.1998 |
0.606 |
|
| 1998 |
Ruvkun G, Sze JY, Hubert O. Transcriptional control of neural function in C elegans Faseb Journal. 12: A1322. |
0.3 |
|
| 1997 |
Slack F, Ruvkun G. Temporal pattern formation by heterochronic genes. Annual Review of Genetics. 31: 611-34. PMID 9442909 DOI: 10.1146/Annurev.Genet.31.1.611 |
0.654 |
|
| 1997 |
Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun G. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature. 389: 994-9. PMID 9353126 DOI: 10.1038/40194 |
0.465 |
|
| 1997 |
Patterson GI, Koweek A, Wong A, Liu Y, Ruvkun G. The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway. Genes & Development. 11: 2679-90. PMID 9334330 DOI: 10.1101/Gad.11.20.2679 |
0.42 |
|
| 1997 |
Hobert O, Mori I, Yamashita Y, Honda H, Ohshima Y, Liu Y, Ruvkun G. Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron. 19: 345-57. PMID 9292724 DOI: 10.1016/S0896-6273(00)80944-7 |
0.747 |
|
| 1997 |
Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science (New York, N.Y.). 277: 942-6. PMID 9252323 DOI: 10.1126/Science.277.5328.942 |
0.723 |
|
| 1997 |
Sluder AE, Lindblom T, Ruvkun G. The Caenorhabditis elegans orphan nuclear hormone receptor gene nhr-2 functions in early embryonic development. Developmental Biology. 184: 303-19. PMID 9133437 DOI: 10.1006/Dbio.1997.8544 |
0.513 |
|
| 1997 |
Sze JY, Liu Y, Ruvkun G. VP16-activation of the C. elegans neural specification transcription factor UNC-86 suppresses mutations in downstream genes and causes defects in neural migration and axon outgrowth. Development (Cambridge, England). 124: 1159-68. PMID 9102303 |
0.446 |
|
| 1996 |
Ha I, Wightman B, Ruvkun G. A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation. Genes & Development. 10: 3041-50. PMID 8957004 DOI: 10.1101/Gad.10.23.3041 |
0.471 |
|
| 1996 |
Morris JZ, Tissenbaum HA, Ruvkun G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature. 382: 536-9. PMID 8700226 DOI: 10.1038/382536A0 |
0.408 |
|
| 1996 |
Barnes TM, Jin Y, Horvitz HR, Ruvkun G, Hekimi S. The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein. Journal of Neurochemistry. 67: 46-57. PMID 8667025 DOI: 10.1046/J.1471-4159.1996.67010046.X |
0.696 |
|
| 1996 |
Baumeister R, Liu Y, Ruvkun G. Lineage-specific regulators couple cell lineage asymmetry to the transcription of the Caenorhabditis elegans POU gene unc-86 during neurogenesis. Genes & Development. 10: 1395-410. PMID 8647436 DOI: 10.1101/Gad.10.11.1395 |
0.462 |
|
| 1994 |
Gottlieb S, Ruvkun G. daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans. Genetics. 137: 107-20. PMID 8056303 |
0.399 |
|
| 1994 |
Greenstein D, Hird S, Plasterk RH, Andachi Y, Kohara Y, Wang B, Finney M, Ruvkun G. Targeted mutations in the Caenorhabditis elegans POU homeo box gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiation. Genes & Development. 8: 1935-48. PMID 7958868 DOI: 10.1101/Gad.8.16.1935 |
0.722 |
|
| 1993 |
Wightman B, Ha I, Ruvkun G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell. 75: 855-62. PMID 8252622 DOI: 10.1016/0092-8674(93)90530-4 |
0.525 |
|
| 1993 |
Bürglin TR, Ruvkun G. The Caenorhabditis elegans homeobox gene cluster. Current Opinion in Genetics & Development. 3: 615-20. PMID 7902148 DOI: 10.1016/0959-437X(93)90097-9 |
0.432 |
|
| 1992 |
Bürglin TR, Ruvkun G. New motif in PBX genes. Nature Genetics. 1: 319-20. PMID 1363814 DOI: 10.1038/Ng0892-319 |
0.444 |
|
| 1992 |
Xue D, Finney M, Ruvkun G, Chalfie M. Regulation of the mec-3 gene by the C.elegans homeoproteins UNC-86 and MEC-3. The Embo Journal. 11: 4969-79. PMID 1361171 DOI: 10.1002/J.1460-2075.1992.Tb05604.X |
0.683 |
|
| 1992 |
Miller DM, Shen MM, Shamu CE, Bürglin TR, Ruvkun G, Dubois ML, Ghee M, Wilson L. C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons. Nature. 355: 841-5. PMID 1347150 DOI: 10.1038/355841A0 |
0.449 |
|
| 1992 |
Ruvkun G. Cell signalling. A molecular growth industry. Nature. 360: 711-2. PMID 1334532 DOI: 10.1038/360711A0 |
0.34 |
|
| 1991 |
Ruvkun G, Finney M. Regulation of transcription and cell identity by POU domain proteins. Cell. 64: 475-8. PMID 1991317 DOI: 10.1016/0092-8674(91)90227-P |
0.481 |
|
| 1991 |
Arasu P, Wightman B, Ruvkun G. Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28. Genes & Development. 5: 1825-33. PMID 1916265 DOI: 10.1101/Gad.5.10.1825 |
0.48 |
|
| 1991 |
Wightman B, Bürglin TR, Gatto J, Arasu P, Ruvkun G. Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development. Genes & Development. 5: 1813-24. PMID 1916264 DOI: 10.1101/Gad.5.10.1813 |
0.477 |
|
| 1991 |
Ruvkun G, Wightman B, Bürglin T, Arasu P. Dominant gain-of-function mutations that lead to misregulation of the C. elegans heterochronic gene lin-14, and the evolutionary implications of dominant mutations in pattern-formation genes. Development (Cambridge, England). Supplement. 1: 47-54. PMID 1742500 |
0.444 |
|
| 1991 |
Bürglin TR, Ruvkun G, Coulson A, Hawkins NC, McGhee JD, Schaller D, Wittmann C, Müller F, Waterston RH. Nematode homeobox cluster. Nature. 351: 703. PMID 1676487 DOI: 10.1038/351703A0 |
0.298 |
|
| 1990 |
Ruvkun G, Gilbert W, Horvitz HR. Detection of mutations and DNA polymorphisms using whole genome Southern Cross hybridization. Nucleic Acids Research. 18: 809-15. PMID 2315039 DOI: 10.1093/Nar/18.4.809 |
0.763 |
|
| 1990 |
Finney M, Ruvkun G. The unc-86 gene product couples cell lineage and cell identity in C. elegans. Cell. 63: 895-905. PMID 2257628 DOI: 10.1016/0092-8674(90)90493-X |
0.451 |
|
| 1989 |
Ruvkun G, Giusto J. The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch. Nature. 338: 313-9. PMID 2922060 DOI: 10.1038/338313A0 |
0.472 |
|
| 1989 |
Bürglin TR, Finney M, Coulson A, Ruvkun G. Caenorhabditis elegans has scores of homoeobox-containing genes. Nature. 341: 239-43. PMID 2571091 DOI: 10.1038/341239A0 |
0.489 |
|
| 1989 |
Ruvkun G, Ambros V, Coulson A, Waterston R, Sulston J, Horvitz HR. Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14. Genetics. 121: 501-16. PMID 2565854 |
0.766 |
|
| 1989 |
Bürglin TR, Finney M, Coulson A, Ruvkun G. Caenorbabditis elegans has scores of homeobox-containing genes Trends in Genetics. 5: 393. DOI: 10.1016/0168-9525(89)90189-3 |
0.443 |
|
| 1988 |
Herr W, Sturm RA, Clerc RG, Corcoran LM, Baltimore D, Sharp PA, Ingraham HA, Rosenfeld MG, Finney M, Ruvkun G. The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products. Genes & Development. 2: 1513-6. PMID 3215510 DOI: 10.1101/Gad.2.12A.1513 |
0.647 |
|
| 1988 |
Finney M, Ruvkun G, Horvitz HR. The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors. Cell. 55: 757-69. PMID 2903797 DOI: 10.1016/0092-8674(88)90132-8 |
0.723 |
|
| 1982 |
Ruvkun GB, Long SR, Meade HM, van den Bos RC, Ausubel FM. ISRm1: A Rhizobium meliloti insertion sequence that transposes preferentially into nitrogen fixation genes. Journal of Molecular and Applied Genetics. 1: 405-18. PMID 6296251 |
0.654 |
|
| 1982 |
Ruvkun GB, Sundaresan V, Ausubel FM. Specific protection of nucleotides in the lac operator from DMS methylation and DNase I nicking by crude bacterial cell extracts. Gene. 18: 247-55. PMID 6290328 DOI: 10.1016/0378-1119(82)90162-7 |
0.665 |
|
| 1982 |
Ruvkun GB, Sundaresan V, Ausubel FM. Directed transposon Tn5 mutagenesis and complementation analysis of Rhizobium meliloti symbiotic nitrogen fixation genes. Cell. 29: 551-9. PMID 6288262 DOI: 10.1016/0092-8674(82)90171-4 |
0.711 |
|
| 1982 |
Meade HM, Long SR, Ruvkun GB, Brown SE, Ausubel FM. Physical and genetic characterization of symbiotic and auxotrophic mutants of Rhizobium meliloti induced by transposon Tn5 mutagenesis. Journal of Bacteriology. 149: 114-22. PMID 6274841 DOI: 10.1128/Jb.149.1.114-122.1982 |
0.638 |
|
| 1981 |
Ruvkun GB, Ausubel FM. A general method for site-directed mutagenesis in prokaryotes. Nature. 289: 85-8. PMID 6256652 DOI: 10.1038/289085A0 |
0.56 |
|
| 1981 |
Ruvkun GB, Long SR, Meade HM, Ausubel FM. Molecular Genetic Analysis of Klebsiella Pneumoniae Nitrogen-fixation (nif) Genes: Appendix: Molecular Genetics of Symbiotic Nitrogen Fixation Cold Spring Harbor Symposia On Quantitative Biology. 45: 487-499. DOI: 10.1101/Sqb.1981.045.01.065 |
0.63 |
|
| 1980 |
Ruvkun GB, Ausubel FM. Interspecies homology of nitrogenase genes. Proceedings of the National Academy of Sciences of the United States of America. 77: 191-5. PMID 6987649 DOI: 10.1073/Pnas.77.1.191 |
0.539 |
|
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