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Laura Gasparini, MD - Publications

Affiliations: 
Pharmacology University of Rome, Roma, Lazio, Italy 
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48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Bichmann M, Prat Oriol N, Ercan-Herbst E, Schöndorf DC, Gomez Ramos B, Schwärzler V, Neu M, Schlüter A, Wang X, Jin L, Hu C, Tian Y, Ried JS, Haberkant P, Gasparini L, et al. SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease. Molecular Neurodegeneration. 16: 46. PMID 34215303 DOI: 10.1186/s13024-021-00468-x  0.301
2021 Bichmann M, Prat Oriol N, Ercan-Herbst E, Schöndorf DC, Gomez Ramos B, Schwärzler V, Neu M, Schlüter A, Wang X, Jin L, Hu C, Tian Y, Ried JS, Haberkant P, Gasparini L, et al. SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease. Molecular Neurodegeneration. 16: 46. PMID 34215303 DOI: 10.1186/s13024-021-00468-x  0.301
2019 Schlegel K, Awwad K, Heym RG, Holzinger D, Doell A, Barghorn S, Jahn TR, Klein C, Mordashova Y, Schulz M, Gasparini L. N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain. Acta Neuropathologica Communications. 7: 177. PMID 31722749 DOI: 10.1186/S40478-019-0831-2  0.377
2018 Barini E, Meinhardt M, Hoppe J, Plotzky G, Mairhofer I, Holzinger D, Janson B, Beckenbach E, Keller A, Mezler M, Bodie K, Miesbauer L, Williams J, Heym RG, Gasparini L, et al. P3-092: Identification Of Secreted Tau Species And Its Relation To Csf Tau In Mouse Models Of Tauopathy Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.1448  0.319
2017 Mahajani S, Giacomini C, Marinaro F, De Pietri Tonelli D, Contestabile A, Gasparini L. Lamin B1 levels modulate differentiation into neurons during embryonic corticogenesis. Scientific Reports. 7: 4897. PMID 28687747 DOI: 10.1038/S41598-017-05078-6  0.31
2016 Schierle GS, Michel CH, Gasparini L. Advanced imaging of tau pathology in Alzheimer Disease: New perspectives from super resolution microscopy and label-free nanoscopy. Microscopy Research and Technique. PMID 27324149 DOI: 10.1002/Jemt.22698  0.382
2016 Mazzaro N, Barini E, Spillantini MG, Goedert M, Medini P, Gasparini L. Tau-Driven Neuronal and Neurotrophic Dysfunction in a Mouse Model of Early Tauopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 2086-100. PMID 26888921 DOI: 10.1523/Jneurosci.0774-15.2016  0.385
2016 Barini E, Antico O, Zhao Y, Asta F, Tucci V, Catelani T, Marotta R, Xu H, Gasparini L. Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy. Molecular Neurodegeneration. 11: 16. PMID 26858121 DOI: 10.1186/S13024-016-0082-7  0.379
2015 Giacomini C, Mahajani S, Ruffilli R, Marotta R, Gasparini L. Lamin B1 protein is required for dendrite development in primary mouse cortical neurons. Molecular Biology of the Cell. PMID 26510501 DOI: 10.1091/Mbc.E15-05-0307  0.315
2015 Chegaev K, Federico A, Marini E, Rolando B, Fruttero R, Morbin M, Rossi G, Fugnanesi V, Bastone A, Salmona M, Badiola NB, Gasparini L, Cocco S, Ripoli C, Grassi C, et al. NO-donor thiacarbocyanines as multifunctional agents for Alzheimer's disease. Bioorganic & Medicinal Chemistry. 23: 4688-98. PMID 26078011 DOI: 10.1016/J.Bmc.2015.05.050  0.355
2014 Averaimo S, Gritti M, Barini E, Gasparini L, Mazzanti M. CLIC1 functional expression is required for cAMP-induced neurite elongation in post-natal mouse retinal ganglion cells. Journal of Neurochemistry. 131: 444-56. PMID 25060644 DOI: 10.1111/Jnc.12832  0.326
2014 Ferrera D, Mazzaro N, Canale C, Gasparini L. Resting microglia react to Aβ42 fibrils but do not detect oligomers or oligomer-induced neuronal damage. Neurobiology of Aging. 35: 2444-57. PMID 24973120 DOI: 10.1016/J.Neurobiolaging.2014.05.023  0.413
2014 Ferrera D, Canale C, Marotta R, Mazzaro N, Gritti M, Mazzanti M, Capellari S, Cortelli P, Gasparini L. Lamin B1 overexpression increases nuclear rigidity in autosomal dominant leukodystrophy fibroblasts. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 3906-18. PMID 24858279 DOI: 10.1096/Fj.13-247635  0.308
2013 Mazzaro N, Barini E, Goedert M, Spillantini M, Medini P, Gasparini L. Tauopathy-induced retinal dysfunction in the P301S mutant human tau transgenic mouse Molecular Neurodegeneration. 8: P57. DOI: 10.1186/1750-1326-8-S1-P57  0.373
2013 Barini E, Mazzaro N, Spillantini MG, Goedert M, Medini P, Gasparini L. Alterations of neurotrophin signaling in the retina of the P301S mutant human tau transgenic mouse Alzheimers & Dementia. 9: 169. DOI: 10.1016/J.Jalz.2013.05.266  0.37
2013 Mazzaro N, Barini E, Spillantini MG, Goedert M, Medini P, Gasparini L. Neurotrophin signaling is altered in the retina of the P301S mutant human tau transgenic mouse Alzheimers & Dementia. 9. DOI: 10.1016/J.Jalz.2013.05.265  0.311
2011 Gasparini L, Crowther RA, Martin KR, Berg N, Coleman M, Goedert M, Spillantini MG. Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice: effects on axonal viability. Neurobiology of Aging. 32: 419-33. PMID 19356824 DOI: 10.1016/J.Neurobiolaging.2009.03.002  0.334
2010 Contestabile A, Benfenati F, Gasparini L. Communication breaks-Down: from neurodevelopment defects to cognitive disabilities in Down syndrome. Progress in Neurobiology. 91: 1-22. PMID 20097253 DOI: 10.1016/J.Pneurobio.2010.01.003  0.314
2010 Scattoni ML, Gasparini L, Alleva E, Goedert M, Calamandrei G, Spillantini MG. Early behavioural markers of disease in P301S tau transgenic mice. Behavioural Brain Research. 208: 250-7. PMID 20004218 DOI: 10.1016/J.Bbr.2009.12.002  0.318
2009 Chen Y, Zhou K, Wang R, Liu Y, Kwak YD, Ma T, Thompson RC, Zhao Y, Smith L, Gasparini L, Luo Z, Xu H, Liao FF. Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription. Proceedings of the National Academy of Sciences of the United States of America. 106: 3907-12. PMID 19237574 DOI: 10.1073/Pnas.0807991106  0.407
2009 Ferrera D, Canale C, Benfenati F, Gasparini L. Effects of beta-amyloid oligomers on neuronal viability and microglial activation Alzheimers & Dementia. 5: 226. DOI: 10.1016/J.Jalz.2009.04.173  0.326
2007 Magnani E, Fan J, Gasparini L, Golding M, Williams M, Schiavo G, Goedert M, Amos LA, Spillantini MG. Interaction of tau protein with the dynactin complex. The Embo Journal. 26: 4546-54. PMID 17932487 DOI: 10.1038/Sj.Emboj.7601878  0.35
2007 Gasparini L, Terni B, Spillantini MG. Frontotemporal dementia with tau pathology. Neuro-Degenerative Diseases. 4: 236-53. PMID 17596718 DOI: 10.1159/000101848  0.37
2006 Bernardo A, Gasparini L, Ongini E, Minghetti L. Dynamic regulation of microglial functions by the non-steroidal anti-inflammatory drug NCX 2216: implications for chronic treatments of neurodegenerative diseases. Neurobiology of Disease. 22: 25-32. PMID 16307889 DOI: 10.1016/J.Nbd.2005.09.012  0.331
2006 Gasparini L, Goedert M, Spillantini MG. P1-086: Hyperphosphorylated tau accumulates in retinal ganglion neurons of P301S tau transgenic mice Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.461  0.329
2005 Gasparini L, Ongini E, Wilcock D, Morgan D. Activity of flurbiprofen and chemically related anti-inflammatory drugs in models of Alzheimer's disease. Brain Research. Brain Research Reviews. 48: 400-8. PMID 15850679 DOI: 10.1016/J.Brainresrev.2004.12.029  0.395
2005 Bernardo A, Ajmone-Cat MA, Gasparini L, Ongini E, Minghetti L. Nuclear receptor peroxisome proliferator-activated receptor-gamma is activated in rat microglial cells by the anti-inflammatory drug HCT1026, a derivative of flurbiprofen. Journal of Neurochemistry. 92: 895-903. PMID 15686492 DOI: 10.1111/J.1471-4159.2004.02932.X  0.318
2004 Gasparini L, Ongini E, Wenk G. Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer's disease: old and new mechanisms of action. Journal of Neurochemistry. 91: 521-36. PMID 15485484 DOI: 10.1111/J.1471-4159.2004.02743.X  0.402
2004 Gasparini L, Rusconi L, Xu H, del Soldato P, Ongini E. Modulation of beta-amyloid metabolism by non-steroidal anti-inflammatory drugs in neuronal cell cultures. Journal of Neurochemistry. 88: 337-48. PMID 14690522 DOI: 10.1111/J.1471-4159.2004.02154.X  0.393
2003 Ghidoni R, Gasparini L, Alberici A, Benussi L, Barbiero L, Mazzoli F, Nicosia F, Finazzi D, Benerini Gatta L, Albertini A, Zanetti O, Binetti G. Inhibition of energy metabolism down-regulates the Alzheimer related presenilin 2 gene. Journal of Neural Transmission (Vienna, Austria : 1996). 110: 1029-39. PMID 12938025 DOI: 10.1007/S00702-003-0015-9  0.362
2003 Gasparini L, Xu H. Potential roles of insulin and IGF-1 in Alzheimer's disease. Trends in Neurosciences. 26: 404-6. PMID 12900169 DOI: 10.1016/S0166-2236(03)00163-2  0.354
2002 Leem JY, Saura CA, Pietrzik C, Christianson J, Wanamaker C, King LT, Veselits ML, Tomita T, Gasparini L, Iwatsubo T, Xu H, Green WN, Koo EH, Thinakaran G. A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiology of Disease. 11: 64-82. PMID 12460547 DOI: 10.1006/Nbdi.2002.0546  0.337
2002 Gasparini L, Netzer WJ, Greengard P, Xu H. Does insulin dysfunction play a role in Alzheimer's disease? Trends in Pharmacological Sciences. 23: 288-93. PMID 12084635 DOI: 10.1016/S0165-6147(02)02037-0  0.4
2001 Yu C, Kim SH, Ikeuchi T, Xu H, Gasparini L, Wang R, Sisodia SS. Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains. The Journal of Biological Chemistry. 276: 43756-60. PMID 11583985 DOI: 10.1074/Jbc.C100410200  0.346
2001 Benussi L, Alberici A, Mayhaus M, Langer U, Ghidoni R, Mazzoli F, Nicosia F, Barbiero L, Frisoni G, Zanetti O, Gasparini L, Nitsch RM, Binetti G. Detection of the presenilin 1 COOH-terminal fragment in the extracellular compartment: a release enhanced by apoptosis. Experimental Cell Research. 269: 256-65. PMID 11570818 DOI: 10.1006/Excr.2001.5329  0.344
2001 Nicosia F, Alberici A, Benussi L, Gasparini L, Ghidoni R, Mazzoli F, Zanetti O, Frisoni GB, Geroldi C, Binetti G. Analysis of alpha-2-macroglobulin-2 allele as a risk factor in Alzheimer's disease. Dementia and Geriatric Cognitive Disorders. 12: 305-8. PMID 11455130 DOI: 10.1159/000051274  0.316
2001 Gasparini L, Gouras GK, Wang R, Gross RS, Beal MF, Greengard P, Xu H. Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 2561-70. PMID 11306609  0.461
2001 Gasparini L, Gouras GK, Wang R, Gross RS, Beal MF, Greengard P, Xu H. Stimulation of β-Amyloid Precursor Protein Trafficking by Insulin Reduces Intraneuronal β-Amyloid and Requires Mitogen-Activated Protein Kinase Signaling The Journal of Neuroscience. 21: 2561-2570. DOI: 10.1523/Jneurosci.21-08-02561.2001  0.518
2000 Gasparini L, Gouras GK, Wang R, Gross RS, Beal M, Greengard P, Xu H. Insulin-regulated β-amyloid protein trafficking: Stimulated secretion and reduced intracellular accumulation of Aβ in neuronal cell cultures Neurobiology of Aging. 21: 183. DOI: 10.1016/S0197-4580(00)82165-X  0.51
1999 Gasparini L, Benussi L, Bianchetti A, Binetti G, Curti D, Govoni S, Moraschi S, Racchi M, Trabucchi M. Energy metabolism inhibition impairs amyloid precursor protein secretion from Alzheimer's fibroblasts. Neuroscience Letters. 263: 197-200. PMID 10213169 DOI: 10.1016/S0304-3940(99)00155-X  0.375
1998 Benussi L, Govoni S, Gasparini L, Binetti G, Trabucchi M, Bianchetti A, Racchi M. Specific role for protein kinase C alpha in the constitutive and regulated secretion of amyloid precursor protein in human skin fibroblasts. Neuroscience Letters. 240: 97-101. PMID 9486481 DOI: 10.1016/S0304-3940(97)00894-X  0.325
1998 Gasparini L, Racchi M, Binetti G, Trabucchi M, Solerte SB, Alkon D, Etcheberrigaray R, Gibson G, Blass J, Paoletti R, Govoni S. Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 12: 17-34. PMID 9438407 DOI: 10.1096/Fasebj.12.1.17  0.38
1997 Curti D, Rognoni F, Gasparini L, Cattaneo A, Paolillo M, Racchi M, Zani L, Bianchetti A, Trabucchi M, Bergamaschi S, Govoni S. Oxidative metabolism in cultured fibroblasts derived from sporadic Alzheimer's disease (AD) patients. Neuroscience Letters. 236: 13-6. PMID 9404940 DOI: 10.1016/S0304-3940(97)00741-6  0.39
1997 Racchi M, Gasparini L, Trabucchi M, Govoni S. Testing pathophysiological hypotheses of Alzheimer's disease and pharmacological modulation of amyloid precursor protein metabolism: the contribution from the studies on cultured fibroblasts from affected donors. Aging (Milan, Italy). 9: 57-8. PMID 9358886 DOI: 10.1007/Bf03339707  0.369
1997 Gasparini L, Racchi M, Benussi L, Curti D, Binetti G, Bianchetti A, Trabucchi M, Govoni S. Effect of energy shortage and oxidative stress on amyloid precursor protein metabolism in COS cells. Neuroscience Letters. 231: 113-7. PMID 9291153 DOI: 10.1016/S0304-3940(97)00536-3  0.317
1996 Govoni S, Bergamaschi S, Gasparini L, Quaglia C, Racchi M, Cattaneo E, Binetti G, Bianchetti A, Giovetti F, Battaini F, Trabuechi M. Fibroblasts of patients affected by Down's syndrome oversecrete amyloid precursor protein and are hyporesponsive to protein kinase C stimulation. Neurology. 47: 1069-75. PMID 8857747 DOI: 10.1212/Wnl.47.4.1069  0.366
1996 Govoni S, Gasparini L, Racchi M, Trabucchi M. Peripheral cells as an investigational tool for Alzheimer's disease. Life Sciences. 59: 461-8. PMID 8761334 DOI: 10.1016/0024-3205(96)00325-6  0.378
1995 Bergamaschi S, Gasparini L, Quaglia C, Racchi M, Binetti G, Battaini F, Trabucchi M, Bianchetti A, Giovetti F, Govoni S. Modulation of β-amyloid precursor protein secretion by protein kinase C in down's fibroblasts Pharmacological Research. 31: 122. DOI: 10.1016/1043-6618(95)86748-1  0.319
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