Laura Gasparini, MD - Publications

Pharmacology University of Rome, Roma, Lazio, Italy 

49 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Barini E, Antico O, Zhao Y, Asta F, Tucci V, Catelani T, Marotta R, Xu H, Gasparini L. Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy. Molecular Neurodegeneration. 11: 16. PMID 26858121 DOI: 10.1186/s13024-016-0082-7  0.48
2015 Giacomini C, Mahajani S, Ruffilli R, Marotta R, Gasparini L. Lamin B1 protein is required for dendrite development in primary mouse cortical neurons. Molecular Biology of the Cell. PMID 26510501 DOI: 10.1091/mbc.E15-05-0307  0.48
2015 Giorgio E, Robyr D, Spielmann M, Ferrero E, Di Gregorio E, Imperiale D, Vaula G, Stamoulis G, Santoni F, Atzori C, Gasparini L, Ferrera D, Canale C, Guipponi M, Pennacchio LA, et al. A large genomic deletion leads to enhancer adoption by the lamin B1 gene: a second path to autosomal dominant adult-onset demyelinating leukodystrophy (ADLD). Human Molecular Genetics. 24: 3143-54. PMID 25701871 DOI: 10.1093/hmg/ddv065  0.48
2015 Bartoletti-Stella A, Gasparini L, Giacomini C, Corrado P, Terlizzi R, Giorgio E, Magini P, Seri M, Baruzzi A, Parchi P, Brusco A, Cortelli P, Capellari S. Messenger RNA processing is altered in autosomal dominant leukodystrophy. Human Molecular Genetics. 24: 2746-56. PMID 25637521 DOI: 10.1093/hmg/ddv034  0.48
2015 Chegaev K, Federico A, Marini E, Rolando B, Fruttero R, Morbin M, Rossi G, Fugnanesi V, Bastone A, Salmona M, Badiola NB, Gasparini L, Cocco S, Ripoli C, Grassi C, et al. NO-donor thiacarbocyanines as multifunctional agents for Alzheimer's disease Bioorganic and Medicinal Chemistry. DOI: 10.1016/j.bmc.2015.05.050  0.48
2015 Gasparini L, Tornarolli L. A review of the OECD Income Distribution Database Journal of Economic Inequality. DOI: 10.1007/s10888-015-9299-x  0.01
2014 Ferrera D, Mazzaro N, Canale C, Gasparini L. Resting microglia react to Aβ42 fibrils but do not detect oligomers or oligomer-induced neuronal damage. Neurobiology of Aging. 35: 2444-57. PMID 24973120 DOI: 10.1016/j.neurobiolaging.2014.05.023  0.48
2014 Ferrera D, Canale C, Marotta R, Mazzaro N, Gritti M, Mazzanti M, Capellari S, Cortelli P, Gasparini L. Lamin B1 overexpression increases nuclear rigidity in autosomal dominant leukodystrophy fibroblasts. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 3906-18. PMID 24858279 DOI: 10.1096/fj.13-247635  0.48
2014 Tucci V, Kleefstra T, Hardy A, Heise I, Maggi S, Willemsen MH, Hilton H, Esapa C, Simon M, Buenavista MT, McGuffin LJ, Vizor L, Dodero L, Tsaftaris S, Romero R, ... ... Gasparini L, et al. Dominant β-catenin mutations cause intellectual disability with recognizable syndromic features. The Journal of Clinical Investigation. 124: 1468-82. PMID 24614104 DOI: 10.1172/JCI70372  0.48
2013 Colombi I, Mahajani S, Frega M, Gasparini L, Chiappalone M. Effects of antiepileptic drugs on hippocampal neurons coupled to micro-electrode arrays. Frontiers in Neuroengineering. 6: 10. PMID 24312049 DOI: 10.3389/fneng.2013.00010  0.48
2013 Columbaro M, Mattioli E, Maraldi NM, Ortolani M, Gasparini L, D'Apice MR, Postorivo D, Nardone AM, Avnet S, Cortelli P, Liguori R, Lattanzi G. Oct-1 recruitment to the nuclear envelope in adult-onset autosomal dominant leukodystrophy. Biochimica Et Biophysica Acta. 1832: 411-20. PMID 23261988 DOI: 10.1016/j.bbadis.2012.12.006  0.48
2013 Contestabile A, Greco B, Ghezzi D, Tucci V, Benfenati F, Gasparini L. Lithium rescues synaptic plasticity and memory in Down syndrome mice. The Journal of Clinical Investigation. 123: 348-61. PMID 23202733 DOI: 10.1172/JCI64650  0.48
2013 Panina E, Pancheri L, Dalla Betta GF, Gasparini L, Stoppa D. Compact CMOS analog readout circuit for photon counting applications Proceedings of Spie - the International Society For Optical Engineering. 8773. DOI: 10.1117/12.2020975  0.01
2013 Columbaro M, Mattioli E, Maraldi NM, Ortolani M, Gasparini L, D'Apice MR, Postorivo D, Nardone AM, Avnet S, Cortelli P, Liguori R, Lattanzi G. Corrigendum to "Oct-1 recruitment to the nuclear envelope in adult-onset autosomal dominant Leukodystrophy" [Biochim. Biophys. Acta, Mol. Basis Dis. 1832 (3) (March 2013) 411-420] Biochimica Et Biophysica Acta - Molecular Basis of Disease. 1832: 2244. DOI: 10.1016/j.bbadis.2013.09.001  0.48
2011 Gasparini L, Crowther RA, Martin KR, Berg N, Coleman M, Goedert M, Spillantini MG. Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice: effects on axonal viability. Neurobiology of Aging. 32: 419-33. PMID 19356824 DOI: 10.1016/j.neurobiolaging.2009.03.002  0.48
2011 Gasparini L, Bouillet E, Calabrese F, Verscheure O, O'Brien B, O'Donnell M. System and analytics for continuously assessing transport systems from sparse and noisy observations: Case study in Dublin Ieee Conference On Intelligent Transportation Systems, Proceedings, Itsc. 1827-1832. DOI: 10.1109/ITSC.2011.6082982  0.01
2010 Contestabile A, Benfenati F, Gasparini L. Communication breaks-Down: from neurodevelopment defects to cognitive disabilities in Down syndrome. Progress in Neurobiology. 91: 1-22. PMID 20097253 DOI: 10.1016/j.pneurobio.2010.01.003  0.48
2010 Scattoni ML, Gasparini L, Alleva E, Goedert M, Calamandrei G, Spillantini MG. Early behavioural markers of disease in P301S tau transgenic mice. Behavioural Brain Research. 208: 250-7. PMID 20004218 DOI: 10.1016/j.bbr.2009.12.002  0.48
2009 Chen Y, Zhou K, Wang R, Liu Y, Kwak YD, Ma T, Thompson RC, Zhao Y, Smith L, Gasparini L, Luo Z, Xu H, Liao FF. Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription. Proceedings of the National Academy of Sciences of the United States of America. 106: 3907-12. PMID 19237574 DOI: 10.1073/pnas.0807991106  0.48
2008 Gasparini L, Dityatev A. Beta-amyloid and glutamate receptors. Experimental Neurology. 212: 1-4. PMID 18448101 DOI: 10.1016/j.expneurol.2008.03.005  0.48
2007 Magnani E, Fan J, Gasparini L, Golding M, Williams M, Schiavo G, Goedert M, Amos LA, Spillantini MG. Interaction of tau protein with the dynactin complex. The Embo Journal. 26: 4546-54. PMID 17932487 DOI: 10.1038/sj.emboj.7601878  0.48
2007 Gasparini L, Terni B, Spillantini MG. Frontotemporal dementia with tau pathology. Neuro-Degenerative Diseases. 4: 236-53. PMID 17596718 DOI: 10.1159/000101848  0.48
2006 Ronchetti D, Impagnatiello F, Guzzetta M, Gasparini L, Borgatti M, Gambari R, Ongini E. Modulation of iNOS expression by a nitric oxide-releasing derivative of the natural antioxidant ferulic acid in activated RAW 264.7 macrophages. European Journal of Pharmacology. 532: 162-9. PMID 16443213 DOI: 10.1016/j.ejphar.2005.12.034  0.48
2006 Bernardo A, Gasparini L, Ongini E, Minghetti L. Dynamic regulation of microglial functions by the non-steroidal anti-inflammatory drug NCX 2216: implications for chronic treatments of neurodegenerative diseases. Neurobiology of Disease. 22: 25-32. PMID 16307889 DOI: 10.1016/j.nbd.2005.09.012  0.48
2005 Gasparini L, Ongini E, Wilcock D, Morgan D. Activity of flurbiprofen and chemically related anti-inflammatory drugs in models of Alzheimer's disease. Brain Research. Brain Research Reviews. 48: 400-8. PMID 15850679 DOI: 10.1016/j.brainresrev.2004.12.029  0.48
2005 Bernardo A, Ajmone-Cat MA, Gasparini L, Ongini E, Minghetti L. Nuclear receptor peroxisome proliferator-activated receptor-gamma is activated in rat microglial cells by the anti-inflammatory drug HCT1026, a derivative of flurbiprofen. Journal of Neurochemistry. 92: 895-903. PMID 15686492 DOI: 10.1111/j.1471-4159.2004.02932.x  0.48
2004 Gasparini L, Ongini E, Wenk G. Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer's disease: old and new mechanisms of action. Journal of Neurochemistry. 91: 521-36. PMID 15485484 DOI: 10.1111/j.1471-4159.2004.02743.x  0.48
2004 Furlan R, Kurne A, Bergami A, Brambilla E, Maucci R, Gasparini L, Butti E, Comi G, Ongini E, Martino G. A nitric oxide releasing derivative of flurbiprofen inhibits experimental autoimmune encephalomyelitis. Journal of Neuroimmunology. 150: 10-9. PMID 15081244 DOI: 10.1016/j.jneuroim.2004.01.004  0.48
2004 Wenk GL, McGann-Gramling K, Hauss-Wegrzyniak B, Ronchetti D, Maucci R, Rosi S, Gasparini L, Ongini E. Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid. Journal of Neurochemistry. 89: 484-93. PMID 15056291 DOI: 10.1111/j.1471-4159.2004.02359.x  0.48
2004 Gasparini L, Rusconi L, Xu H, del Soldato P, Ongini E. Modulation of beta-amyloid metabolism by non-steroidal anti-inflammatory drugs in neuronal cell cultures. Journal of Neurochemistry. 88: 337-48. PMID 14690522  0.48
2003 Ghidoni R, Gasparini L, Alberici A, Benussi L, Barbiero L, Mazzoli F, Nicosia F, Finazzi D, Benerini Gatta L, Albertini A, Zanetti O, Binetti G. Inhibition of energy metabolism down-regulates the Alzheimer related presenilin 2 gene. Journal of Neural Transmission (Vienna, Austria : 1996). 110: 1029-39. PMID 12938025 DOI: 10.1007/s00702-003-0015-9  0.48
2003 Gasparini L, Xu H. Potential roles of insulin and IGF-1 in Alzheimer's disease. Trends in Neurosciences. 26: 404-6. PMID 12900169 DOI: 10.1016/S0166-2236(03)00163-2  0.48
2002 Leem JY, Saura CA, Pietrzik C, Christianson J, Wanamaker C, King LT, Veselits ML, Tomita T, Gasparini L, Iwatsubo T, Xu H, Green WN, Koo EH, Thinakaran G. A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiology of Disease. 11: 64-82. PMID 12460547 DOI: 10.1006/nbdi.2002.0546  0.48
2002 Gasparini L, Netzer WJ, Greengard P, Xu H. Does insulin dysfunction play a role in Alzheimer's disease? Trends in Pharmacological Sciences. 23: 288-93. PMID 12084635 DOI: 10.1016/S0165-6147(02)02037-0  0.48
2001 Yu C, Kim SH, Ikeuchi T, Xu H, Gasparini L, Wang R, Sisodia SS. Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains. The Journal of Biological Chemistry. 276: 43756-60. PMID 11583985 DOI: 10.1074/jbc.C100410200  0.48
2001 Benussi L, Alberici A, Mayhaus M, Langer U, Ghidoni R, Mazzoli F, Nicosia F, Barbiero L, Frisoni G, Zanetti O, Gasparini L, Nitsch RM, Binetti G. Detection of the presenilin 1 COOH-terminal fragment in the extracellular compartment: a release enhanced by apoptosis. Experimental Cell Research. 269: 256-65. PMID 11570818 DOI: 10.1006/excr.2001.5329  0.48
2001 Nicosia F, Alberici A, Benussi L, Gasparini L, Ghidoni R, Mazzoli F, Zanetti O, Frisoni GB, Geroldi C, Binetti G. Analysis of alpha-2-macroglobulin-2 allele as a risk factor in Alzheimer's disease. Dementia and Geriatric Cognitive Disorders. 12: 305-8. PMID 11455130 DOI: 10.1159/000051274  0.48
2001 Gasparini L, Gouras GK, Wang R, Gross RS, Beal MF, Greengard P, Xu H. Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 2561-70. PMID 11306609  0.48
1999 Gasparini L, Ghidoni R, Alberici AC, Benussi L, Moratto D, Trabucchi M, Growdon JH, Nitsch RM, Binetti G. Modulation of presenilin-1 processing by nitric oxide during apoptosis induced by serum withdrawal and glucose deprivation. Annals of the New York Academy of Sciences. 893: 294-7. PMID 10672252  0.48
1999 Alberici A, Moratto D, Benussi L, Gasparini L, Ghidoni R, Gatta LB, Finazzi D, Frisoni GB, Trabucchi M, Growdon JH, Nitsch RM, Binetti G. Presenilin 1 protein directly interacts with Bcl-2. The Journal of Biological Chemistry. 274: 30764-9. PMID 10521466 DOI: 10.1074/jbc.274.43.30764  0.48
1999 Gasparini L, Benussi L, Bianchetti A, Binetti G, Curti D, Govoni S, Moraschi S, Racchi M, Trabucchi M. Energy metabolism inhibition impairs amyloid precursor protein secretion from Alzheimer's fibroblasts. Neuroscience Letters. 263: 197-200. PMID 10213169 DOI: 10.1016/S0304-3940(99)00155-X  0.48
1998 Benussi L, Govoni S, Gasparini L, Binetti G, Trabucchi M, Bianchetti A, Racchi M. Specific role for protein kinase C alpha in the constitutive and regulated secretion of amyloid precursor protein in human skin fibroblasts. Neuroscience Letters. 240: 97-101. PMID 9486481 DOI: 10.1016/S0304-3940(97)00894-X  0.48
1998 Gasparini L, Racchi M, Binetti G, Trabucchi M, Solerte SB, Alkon D, Etcheberrigaray R, Gibson G, Blass J, Paoletti R, Govoni S. Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 12: 17-34. PMID 9438407  0.48
1998 Gasparini L, Govoni S, Battaini F. A review on the neurobiological basis of memory Archives of Gerontology and Geriatrics. 27: 225-234.  0.48
1997 Curti D, Rognoni F, Gasparini L, Cattaneo A, Paolillo M, Racchi M, Zani L, Bianchetti A, Trabucchi M, Bergamaschi S, Govoni S. Oxidative metabolism in cultured fibroblasts derived from sporadic Alzheimer's disease (AD) patients. Neuroscience Letters. 236: 13-6. PMID 9404940 DOI: 10.1016/S0304-3940(97)00741-6  0.48
1997 Racchi M, Gasparini L, Trabucchi M, Govoni S. Testing pathophysiological hypotheses of Alzheimer's disease and pharmacological modulation of amyloid precursor protein metabolism: the contribution from the studies on cultured fibroblasts from affected donors. Aging (Milan, Italy). 9: 57-8. PMID 9358886  0.48
1997 Gasparini L, Racchi M, Benussi L, Curti D, Binetti G, Bianchetti A, Trabucchi M, Govoni S. Effect of energy shortage and oxidative stress on amyloid precursor protein metabolism in COS cells. Neuroscience Letters. 231: 113-7. PMID 9291153 DOI: 10.1016/S0304-3940(97)00536-3  0.48
1996 Govoni S, Bergamaschi S, Gasparini L, Quaglia C, Racchi M, Cattaneo E, Binetti G, Bianchetti A, Giovetti F, Battaini F, Trabuechi M. Fibroblasts of patients affected by Down's syndrome oversecrete amyloid precursor protein and are hyporesponsive to protein kinase C stimulation. Neurology. 47: 1069-75. PMID 8857747  0.48
1996 Govoni S, Gasparini L, Racchi M, Trabucchi M. Peripheral cells as an investigational tool for Alzheimer's disease. Life Sciences. 59: 461-8. PMID 8761334 DOI: 10.1016/0024-3205(96)00325-6  0.48
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