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David E. Kang, PhD - Publications

Affiliations: 
1993-2004 Neurosciences University of California, San Diego, La Jolla, CA 
 2004-2012 Neurosciences University of California, San Diego, La Jolla, CA 
 2009-2012 Biomedical Sciences Seoul National University, Seoul, South Korea 
 2012- Molecular Medicine USF Health Byrd Alzheimer's Institute 
Area:
Alzheimer's disease, amyloid, presenilin, tau, TDP-43, catenin, LRP, CHCHD10, mitochondria, synapse
Website:
http://www.kang-lab.com/
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80 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Sridharan PS, Koh Y, Miller E, Hu D, Chakraborty S, Tripathi SJ, Kee TR, Chaubey K, Vázquez-Rosa E, Barker S, Liu H, León-Alvarado RA, Franke K, Cintrón-Pérez CJ, Dhar M, ... ... Kang DE, et al. Acutely blocking excessive mitochondrial fission prevents chronic neurodegeneration after traumatic brain injury. Cell Reports. Medicine. 101715. PMID 39241772 DOI: 10.1016/j.xcrm.2024.101715  0.772
2024 Karunarathne K, Kee TR, Jeon H, Cazzaro S, Gamage YI, Pan J, Woo JA, Kang DE, Muschol M. Crystal Violet Selectively Detects Aβ Oligomers but Not Fibrils In Vitro and in Alzheimer's Disease Brain Tissue. Biomolecules. 14. PMID 38927020 DOI: 10.3390/biom14060615  0.806
2023 Liu T, Wetzel L, Zhu Z, Kumaraguru P, Gorthi V, Yan Y, Bukhari MZ, Ermekbaeva A, Jeon H, Kee TR, Woo JA, Kang DE. Disruption of Mitophagy Flux through the PARL-PINK1 Pathway by CHCHD10 Mutations or CHCHD10 Depletion. Cells. 12. PMID 38132101 DOI: 10.3390/cells12242781  0.8
2023 Woo JA, Liu T, Fang CC, Cazzaro S, Kee T, LePochat P, Yrigoin K, Penn C, Zhao X, Wang X, Liggett SB, Kang DE. Author Correction: Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics. Communications Biology. 6: 1283. PMID 38114710 DOI: 10.1038/s42003-023-05644-x  0.799
2023 Cazzaro S, Woo JA, Wang X, Liu T, Rego S, Kee TR, Koh Y, Vázquez-Rosa E, Pieper AA, Kang DE. Slingshot homolog-1-mediated Nrf2 sequestration tips the balance from neuroprotection to neurodegeneration in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 120: e2217128120. PMID 37463212 DOI: 10.1073/pnas.2217128120  0.803
2023 Alici H, Uversky VN, Liu T, Kang DE, Woo JA, Coskuner-Weber O. Frontotemporal Dementia-Related V57E Mutation Impairs Mitochondrial Function and Alters the Structural Properties of CHCHD10. Acs Chemical Neuroscience. PMID 37194187 DOI: 10.1021/acschemneuro.3c00125  0.423
2023 Woo JA, Castaño M, Kee TR, Lee J, Koziol-White CJ, An SS, Kim D, Kang DE, Liggett SB. A Par3/LIM Kinase/Cofilin Pathway Mediates Human Airway Smooth Muscle Relaxation by TAS2R14. American Journal of Respiratory Cell and Molecular Biology. PMID 36662576 DOI: 10.1165/rcmb.2022-0303OC  0.767
2022 Yan Y, Wang X, Chaput D, Shin MK, Koh Y, Gan L, Pieper AA, Woo JA, Kang DE. X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women. Cell. PMID 36198316 DOI: 10.1016/j.cell.2022.09.002  0.322
2022 Cazzaro S, Fang C, Khan H, Witas R, Kee TR, Woo JA, Kang DE. Slingshot homolog-1 mediates the secretion of small extracellular vesicles containing misfolded proteins by regulating autophagy cargo receptors and actin dynamics. Frontiers in Aging Neuroscience. 14: 933979. PMID 36092812 DOI: 10.3389/fnagi.2022.933979  0.812
2022 Liu T, Woo JA, Bukhari MZ, Wang X, Yan Y, Buosi SC, Ermekbaeva A, Sista A, Kotsiviras P, LePochat P, Chacko A, Zhao X, Kang DE. Modulation of synaptic plasticity, motor unit physiology, and TDP-43 pathology by CHCHD10. Acta Neuropathologica Communications. 10: 95. PMID 35787294 DOI: 10.1186/s40478-022-01386-9  0.501
2022 Kee TR, Wehinger JL, Gonzalez PE, Nguyen E, McGill Percy KC, Khan SA, Chaput D, Wang X, Liu T, Kang DE, Woo JA. Pathological characterization of a novel mouse model expressing the PD-linked CHCHD2-T61I mutation. Human Molecular Genetics. PMID 35786718 DOI: 10.1093/hmg/ddac083  0.793
2022 Woo JA, Yan Y, Kee TR, Cazzaro S, McGill Percy KC, Wang X, Liu T, Liggett SB, Kang DE. β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy. Life Science Alliance. 5. PMID 34862271 DOI: 10.26508/lsa.202101183  0.806
2021 Kee TR, Espinoza Gonzalez P, Wehinger JL, Bukhari MZ, Ermekbaeva A, Sista A, Kotsiviras P, Liu T, Kang DE, Woo JA. Mitochondrial CHCHD2: Disease-Associated Mutations, Physiological Functions, and Current Animal Models. Frontiers in Aging Neuroscience. 13: 660843. PMID 33967741 DOI: 10.3389/fnagi.2021.660843  0.777
2020 Palavicini JP, Chen J, Wang C, Wang J, Qin C, Baeuerle E, Wang X, Woo JA, Kang DE, Musi N, Dupree JL, Han X. Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes. Jci Insight. 5. PMID 33148881 DOI: 10.1172/jci.insight.137286  0.664
2020 Fang C, Woo JA, Liu T, Zhao X, Cazzaro S, Yan Y, Matlack J, Kee T, LePochat P, Kang DE. SSH1 impedes SQSTM1/p62 flux and MAPT/Tau clearance independent of CFL (cofilin) activation. Autophagy. 1-22. PMID 33044112 DOI: 10.1080/15548627.2020.1816663  0.808
2020 Liu T, Woo JA, Bukhari MZ, LePochat P, Chacko A, Selenica MB, Yan Y, Kotsiviras P, Buosi SC, Zhao X, Kang DE. CHCHD10-regulated OPA1-mitofilin complex mediates TDP-43-induced mitochondrial phenotypes associated with frontotemporal dementia. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32369233 DOI: 10.1096/Fj.201903133Rr  0.769
2020 Woo JA, Liu T, Fang CC, Castaño MA, Kee T, Yrigoin K, Yan Y, Cazzaro S, Matlack J, Wang X, Zhao X, Kang DE, Liggett SB. β-Arrestin2 oligomers impair the clearance of pathological tau and increase tau aggregates. Proceedings of the National Academy of Sciences of the United States of America. PMID 32071246 DOI: 10.1073/Pnas.1917194117  0.803
2019 Woo JA, Liu T, Fang CC, Cazzaro S, Kee T, LePochat P, Yrigoin K, Penn C, Zhao X, Wang X, Liggett SB, Kang DE. Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics. Communications Biology. 2: 112. PMID 31924969 DOI: 10.1038/s42003-019-0359-9  0.831
2019 Liu T, Woo JA, Yan Y, LePochat P, Bukhari MZ, Kang DE. Dual role of cofilin in APP trafficking and amyloid-β clearance. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201901268R. PMID 31646885 DOI: 10.1096/Fj.201901268R  0.81
2019 Kang DE, Woo JA. Cofilin, a Master Node Regulating Cytoskeletal Pathogenesis in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 31594228 DOI: 10.3233/Jad-190585  0.793
2019 Woo JA, Liu T, Fang CC, Cazzaro S, Kee T, LePochat P, Yrigoin K, Penn C, Zhao X, Wang X, Liggett SB, Kang DE. Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics. Communications Biology. 2: 112. PMID 30911686 DOI: 10.1038/s42003-019-0359-9  0.815
2019 Woo JA, Liu T, Fang C, Cazzaro S, Kee T, Lepochat P, Yrigoin K, Zhao X, Wang X, Liggett S, Kang D. Role of cofilin in tau/microtubule dynamics and tauopathy Ibro Reports. 6: S366. DOI: 10.1016/J.Ibror.2019.07.1163  0.779
2019 Kang D, Fang C, Woo JA, Liu T, Cazzaro S, Zhao X. Slingshot-1 impairs the clearance of mitochondria and tau via p62 Ibro Reports. 6: S356. DOI: 10.1016/J.Ibror.2019.07.1131  0.772
2017 Woo JA, Liu T, Zhao X, Trotter C, Yrigoin K, Cazzaro S, Narvaez E, Khan H, Witas R, Bukhari A, Makati K, Wang X, Dickey C, Kang DE. Enhanced tau pathology via RanBP9 and Hsp90/Hsc70 chaperone complexes. Human Molecular Genetics. 26: 3973-3988. PMID 29016855 DOI: 10.1093/Hmg/Ddx284  0.813
2017 Liu T, Wang F, LePochat P, Woo JA, Bukhari MZ, Hong KW, Trotter C, Kang DE. Cofilin-mediated Neuronal Apoptosis via p53 Translocation and PLD1 Regulation. Scientific Reports. 7: 11532. PMID 28912445 DOI: 10.1038/S41598-017-09996-3  0.791
2017 Woo JA, Liu T, Trotter C, Fang CC, De Narvaez E, LePochat P, Maslar D, Bukhari A, Zhao X, Deonarine A, Westerheide SD, Kang DE. Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity. Nature Communications. 8: 15558. PMID 28585542 DOI: 10.1038/Ncomms15558  0.771
2016 Woo JA, Liu T, Penn C, De Narvaez E, Maslar D, Fang C, Bukhari A, LePochat P, Makati K, Zhao X, Kang DE. P4-090: Chchd10 Mutations Synergize with TDP-43 to Promote Neuronal Apoptosis Alzheimer's & Dementia. 12: P1046-P1047. DOI: 10.1016/J.Jalz.2016.06.2179  0.734
2016 Liu T, Wang F, LePochat P, Ruela M, Vega J, Kang DE. P3-119: Cofilin-Mediated Neuronal Apoptosis VIA PLD1 Activity and P53 Translocation Alzheimer's & Dementia. 12: P865-P865. DOI: 10.1016/J.Jalz.2016.06.1777  0.442
2015 Woo JA, Zhao X, Khan H, Penn C, Wang X, Joly-Amado A, Weeber E, Morgan D, Kang DE. Slingshot-Cofilin activation mediates mitochondrial and synaptic dysfunction via Aβ ligation to β1-integrin conformers. Cell Death and Differentiation. 22: 1069-70. PMID 25941167 DOI: 10.1038/Cdd.2015.41  0.731
2015 Woo JA, Boggess T, Uhlar C, Wang X, Khan H, Cappos G, Joly-Amado A, De Narvaez E, Majid S, Minamide LS, Bamburg JR, Morgan D, Weeber E, Kang DE. RanBP9 at the intersection between cofilin and Aβ pathologies: rescue of neurodegenerative changes by RanBP9 reduction. Cell Death & Disease. 6: 1676. PMID 25741591 DOI: 10.1038/Cddis.2015.37  0.774
2015 Woo JA, Zhao X, Khan H, Penn C, Wang X, Joly-Amado A, Weeber E, Morgan D, Kang DE. Slingshot-Cofilin activation mediates mitochondrial and synaptic dysfunction via Aβ ligation to β1-integrin conformers. Cell Death and Differentiation. 22: 921-34. PMID 25698445 DOI: 10.1038/cdd.2015.5  0.393
2015 Lakshmana MK, Hayes CD, Bennett SP, Bianchi E, Reddy KM, Koo EH, Kang DE. Errata: The article, "Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain," (The FASEB Journal (2012) 26, (2072-2083) DOI:10.1096/fj.11-196709) Faseb Journal. 29: 1124. DOI: 10.1096/fj.11-196709ERR  0.642
2014 Wang R, Palavicini JP, Wang H, Maiti P, Bianchi E, Xu S, Lloyd BN, Dawson-Scully K, Kang DE, Lakshmana MK. RanBP9 overexpression accelerates loss of dendritic spines in a mouse model of Alzheimer's disease. Neurobiology of Disease. 69: 169-79. PMID 24892886 DOI: 10.1016/J.Nbd.2014.05.029  0.371
2014 Woo JA, Boggess T, Khan H, Uhlar C, Wang X, Cappos G, Majid S, Narvaez ED, Amado AJ, Morgan D, Weeber E, Kang D. Endogenous Ranbp9 Promotes Cofilin-Actin Rod Pathology, Mitochondrial Translocation Of Cofilin, Abeta Deposition, And Synaptic And Contextual Memory Deficits Alzheimers & Dementia. 10: 483. DOI: 10.1016/J.Jalz.2014.05.709  0.363
2014 Kang DE, Woo JA, Khan H, Uhlar C, Boggess T, Wang X, Joly-Amado A, Cappos G, Zhao X, Weeber E, Morgan D. O3-05-02: COORDINATED ROLES OF COFILIN, SSH1, RANBP9 AND BETA1-INTEGRIN IN ABETA OLIGOMER-INDUCED SYNAPTIC DEFICITS AND APP PROCESSING Alzheimer's & Dementia. 10: P217-P217. DOI: 10.1016/J.Jalz.2014.04.294  0.726
2013 Almenar-Queralt A, Kim SN, Benner C, Herrera CM, Kang DE, Garcia-Bassets I, Goldstein LS. Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation. The Journal of Biological Chemistry. 288: 35222-36. PMID 24145027 DOI: 10.1074/Jbc.M113.513705  0.342
2013 Roh SE, Woo JA, Lakshmana MK, Uhlar C, Ankala V, Boggess T, Liu T, Hong YH, Mook-Jung I, Kim SJ, Kang DE. Mitochondrial dysfunction and calcium deregulation by the RanBP9-cofilin pathway. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 4776-89. PMID 23982146 DOI: 10.1096/Fj.13-234765  0.783
2013 Palavicini JP, Lloyd BN, Hayes CD, Bianchi E, Kang DE, Dawson-Scully K, Lakshmana MK. RanBP9 Plays a Critical Role in Neonatal Brain Development in Mice. Plos One. 8: e66908. PMID 23840553 DOI: 10.1371/Journal.Pone.0066908  0.371
2013 Palavicini JP, Wang H, Bianchi E, Xu S, Rao JS, Kang DE, Lakshmana MK. RanBP9 aggravates synaptic damage in the mouse brain and is inversely correlated to spinophilin levels in Alzheimer's brain synaptosomes. Cell Death & Disease. 4: e667. PMID 23764848 DOI: 10.1038/Cddis.2013.183  0.398
2013 Liu T, Roh SE, Woo JA, Ryu H, Kang DE. Cooperative role of RanBP9 and P73 in mitochondria-mediated apoptosis Cell Death and Disease. 4: 0. PMID 23348590 DOI: 10.1038/Cddis.2012.203  0.79
2013 Song H, Boo JH, Kim KH, Kim C, Kim YE, Ahn JH, Jeon GS, Ryu H, Kang DE, Mook-Jung I. Critical role of presenilin-dependent γ-secretase activity in DNA damage-induced promyelocytic leukemia protein expression and apoptosis. Cell Death and Differentiation. 20: 639-48. PMID 23306558 DOI: 10.1038/Cdd.2012.162  0.392
2012 Woo JA, Jung AR, Lakshmana MK, Bedrossian A, Lim Y, Bu JH, Park SA, Koo EH, Mook-Jung I, Kang DE. Pivotal role of the RanBP9-cofilin pathway in Aβ-induced apoptosis and neurodegeneration. Cell Death and Differentiation. 19: 1413-23. PMID 22361682 DOI: 10.1038/Cdd.2012.14  0.827
2012 Lakshmana MK, Hayes CD, Bennett SP, Bianchi E, Reddy KM, Koo EH, Kang DE. Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 2072-83. PMID 22294787 DOI: 10.1096/Fj.11-196709  0.727
2012 Woo JA, Roh SE, Lakshmana MK, Kang DE. Pivotal role of RanBP9 in integrin-dependent focal adhesion signaling and assembly. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 1672-81. PMID 22223749 DOI: 10.1096/Fj.11-194423  0.766
2012 Roh S, Hong Y, Liu T, Kim SJ, Kang D. P2-125: Deregulation of mitochondrial calcium and apoptotic signaling via the RanBP9-cofilin pathway in neurons Alzheimer's & Dementia. 8: P304-P304. DOI: 10.1016/J.Jalz.2012.05.830  0.453
2011 Kang DE, Roh SE, Woo JA, Liu T, Bu JH, Jung AR, Lim Y. The Interface between Cytoskeletal Aberrations and Mitochondrial Dysfunction in Alzheimer's Disease and Related Disorders. Experimental Neurobiology. 20: 67-80. PMID 22110363 DOI: 10.5607/En.2011.20.2.67  0.808
2011 Woo JA, Kang D, Roh S. P1-023: RanBP10, a homologue of the Alzheimer's-associated protein RanBP9, disrupts cell adhesion and migration but fails to promote amyloid beta peptide generation Alzheimer's & Dementia. 7: S118-S118. DOI: 10.1016/J.Jalz.2011.05.303  0.754
2011 Roh S, Hong Y, Liu T, Kim SJ, Kang D. P3-166: RanBP9 promotes mitochondrial dysfunction and calcium deregulation in primary neurons Alzheimer's & Dementia. 7: S570-S570. DOI: 10.1016/J.Jalz.2011.05.1606  0.499
2011 Woo JA, Jung A, Son M, Tak E, Kang D. P3-049: Scaffolding protein RanBP9 potently disrupts focal adhesion signaling and neurogenesis Alzheimer's & Dementia. 7: S530-S530. DOI: 10.1016/J.Jalz.2011.05.1488  0.713
2010 Cheung KH, Mei L, Mak DO, Hayashi I, Iwatsubo T, Kang DE, Foskett JK. Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons. Science Signaling. 3: ra22. PMID 20332427 DOI: 10.1126/Scisignal.2000818  0.376
2010 Lakshmana MK, Chung JY, Wickramarachchi S, Tak E, Bianchi E, Koo EH, Kang DE. A fragment of the scaffolding protein RanBP9 is increased in Alzheimer's disease brains and strongly potentiates amyloid-beta peptide generation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 119-27. PMID 19729516 DOI: 10.1096/Fj.09-136457  0.725
2009 Lakshmana MK, Yoon IS, Chen E, Bianchi E, Koo EH, Kang DE. Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation. The Journal of Biological Chemistry. 284: 11863-72. PMID 19251705 DOI: 10.1074/Jbc.M807345200  0.729
2009 Boo JH, Song H, Kim JE, Kang DE, Mook-Jung I. Accumulation of phosphorylated beta-catenin enhances ROS-induced cell death in presenilin-deficient cells. Plos One. 4: e4172. PMID 19137062 DOI: 10.1371/Journal.Pone.0004172  0.343
2009 Kang DE, Lakshmana MK, Tak E, Koo EH, Yoon I, Chen E. O4-02-02: Role of the LRP-RanBP9 pathway in APP processing and Alzheimer's disease susceptibility Alzheimer's & Dementia. 5: P151-P152. DOI: 10.1016/J.Jalz.2009.05.523  0.68
2008 Lakshmana MK, Chen E, Yoon IS, Kang DE. C-terminal 37 residues of LRP promote the amyloidogenic processing of APP independent of FE65. Journal of Cellular and Molecular Medicine. 12: 2665-74. PMID 18373737 DOI: 10.1111/J.1582-4934.2008.00320.X  0.428
2007 Repetto E, Yoon IS, Zheng H, Kang DE. Presenilin 1 regulates epidermal growth factor receptor turnover and signaling in the endosomal-lysosomal pathway. The Journal of Biological Chemistry. 282: 31504-16. PMID 17716970 DOI: 10.1074/Jbc.M704273200  0.376
2007 Yoon IS, Chen E, Busse T, Repetto E, Lakshmana MK, Koo EH, Kang DE. Low-density lipoprotein receptor-related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 2742-52. PMID 17463224 DOI: 10.1096/Fj.07-8114Com  0.71
2006 Yoon I, Chen E, Yeung S, Repetto E, Koo EH, Kang DE. P2-035: Molecular dissection of the LRP soluble tail in sorting APP to lipid rafts Alzheimer's & Dementia. 2: S242-S242. DOI: 10.1016/J.Jalz.2006.05.872  0.648
2006 Woo S, Ko E, Kim JW, Lee C, Busse T, Kang DE. P4-272: Proteomic profile of COX-1/2 double deficient cells treated with Aβ42 lowering NSAIDS Alzheimer's & Dementia. 2: S596-S597. DOI: 10.1016/J.Jalz.2006.05.2011  0.354
2006 Kang DE, Busse T, Repetto E, Won Kim J, Woo S. P3-420: F-box only protein 11, a target of Aβ42 lowering NSAIDs, interacts with presenilin 1 and alters γ-secretase activity Alzheimer's & Dementia. 2: S499-S500. DOI: 10.1016/J.Jalz.2006.05.1691  0.359
2005 Kang DE, Yoon IS, Repetto E, Busse T, Yermian N, Ie L, Koo EH. Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling. The Journal of Biological Chemistry. 280: 31537-47. PMID 16014629 DOI: 10.1074/Jbc.M500833200  0.704
2005 Chevallier NL, Soriano S, Kang DE, Masliah E, Hu G, Koo EH. Perturbed neurogenesis in the adult hippocampus associated with presenilin-1 A246E mutation. The American Journal of Pathology. 167: 151-9. PMID 15972961 DOI: 10.1016/S0002-9440(10)62962-8  0.793
2005 Yoon IS, Pietrzik CU, Kang DE, Koo EH. Sequences from the low density lipoprotein receptor-related protein (LRP) cytoplasmic domain enhance amyloid beta protein production via the beta-secretase pathway without altering amyloid precursor protein/LRP nuclear signaling. The Journal of Biological Chemistry. 280: 20140-7. PMID 15772078 DOI: 10.1074/Jbc.M413729200  0.78
2004 Kang DE, Busse T, Ie L, Yermian N, Koo EH. P4-295 Role of presenilins in trafficking & signaling of select receptor tyrosine kinases Neurobiology of Aging. 25: S559. DOI: 10.1016/S0197-4580(04)81853-0  0.654
2002 Kang DE, Soriano S, Xia X, Eberhart CG, De Strooper B, Zheng H, Koo EH. Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis. Cell. 110: 751-62. PMID 12297048 DOI: 10.1016/S0092-8674(02)00970-4  0.788
2001 Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, Findlay KA, Smith TE, Murphy MP, Bulter T, Kang DE, Marquez-Sterling N, Golde TE, Koo EH. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature. 414: 212-6. PMID 11700559 DOI: 10.1038/35102591  0.804
2001 Soriano S, Kang DE, Fu M, Pestell R, Chevallier N, Zheng H, Koo EH. Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing. The Journal of Cell Biology. 152: 785-94. PMID 11266469 DOI: 10.1083/Jcb.152.4.785  0.791
2000 Kang DE, Pietrzik CU, Baum L, Chevallier N, Merriam DE, Kounnas MZ, Wagner SL, Troncoso JC, Kawas CH, Katzman R, Koo EH. Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway. The Journal of Clinical Investigation. 106: 1159-66. PMID 11067868 DOI: 10.1172/Jci11013  0.82
2000 Van Uden E, Kang DE, Koo EH, Masliah E. LDL receptor-related protein (LRP) in Alzheimer's disease: towards a unified theory of pathogenesis. Microscopy Research and Technique. 50: 268-72. PMID 10936878 DOI: 10.1002/1097-0029(20000815)50:4<268::Aid-Jemt3>3.0.Co;2-1  0.726
2000 Soriano S, Kang DE, Chevalier N, Koo EH. Absence of presenilin 1 expression enhances β-catenin/LEF signaling independently of notch-1 Neurobiology of Aging. 21: 67. DOI: 10.1016/S0197-4580(00)82522-1  0.769
1999 Berezovska O, Frosch M, McLean P, Knowles R, Koo E, Kang D, Shen J, Lu FM, Lux SE, Tonegawa S, Hyman BT. The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons. Brain Research. Molecular Brain Research. 69: 273-80. PMID 10366748 DOI: 10.1016/S0169-328X(99)00119-9  0.677
1999 Kang DE, Soriano S, Frosch MP, Collins T, Naruse S, Sisodia SS, Leibowitz G, Levine F, Koo EH. Presenilin 1 Facilitates the Constitutive Turnover of β-Catenin: Differential Activity of Alzheimer’s Disease–Linked PS1 Mutants in the β-Catenin–Signaling Pathway The Journal of Neuroscience. 19: 4229-4237. DOI: 10.1523/Jneurosci.19-11-04229.1999  0.786
1998 Tanaka S, Chen X, Xia Y, Kang DE, Matoh N, Sundsmo M, Thomas RG, Katzman R, Thal LJ, Trojanowski JQ, Saitoh T, Ueda K, Masliah E. Association of CYP2D microsatellite polymorphism with Lewy body variant of Alzheimer's disease. Neurology. 50: 1556-62. PMID 9633694 DOI: 10.1212/Wnl.50.6.1556  0.729
1998 Zhang J, Kang DE, Xia W, Okochi M, Mori H, Selkoe DJ, Koo EH. Subcellular distribution and turnover of presenilins in transfected cells. The Journal of Biological Chemistry. 273: 12436-42. PMID 9575200 DOI: 10.1074/Jbc.273.20.12436  0.713
1998 Katzman R, Kang D, Thomas R. Interaction of apolipoprotein E epsilon 4 with other genetic and non-genetic risk factors in late onset Alzheimer disease: problems facing the investigator. Neurochemical Research. 23: 369-76. PMID 9482249 DOI: 10.1023/A:1022461601609  0.542
1997 Komori N, Kittel A, Kang D, Shackelford D, Masliah E, Zivin JA, Saitoh T. Reversible ischemia increases levels of Alzheimer amyloid protein precursor without increasing levels of mRNA in the rabbit spinal cord Molecular Brain Research. 49: 103-112. PMID 9387869 DOI: 10.1016/S0169-328X(97)00133-2  0.616
1997 Kang DE, Saitoh T, Chen X, Xia Y, Masliah E, Hansen LA, Thomas RG, Thal LJ, Katzman R. Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease. Neurology. 49: 56-61. PMID 9222170 DOI: 10.1212/Wnl.49.1.56  0.762
1997 Conrad C, Andreadis A, Trojanowski JQ, Dickson DW, Kang D, Chen X, Wiederholt W, Hansen L, Masliah E, Thal LJ, Katzman R, Xia Y, Saitoh T. Genetic evidence for the involvement of tau in progressive supranuclear palsy. Annals of Neurology. 41: 277-81. PMID 9029080 DOI: 10.1002/Ana.410410222  0.766
1996 Saitoh T, Xia Y, Yoshimoto M, Twai A, Li H, Kang D, Masliah E. 151 What controls Aβ toxicity Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80153-9  0.618
1995 Yoshimoto M, Iwai A, Kang D, Otero DAC, Xia Y, Saitoh T. NACP, the precursor protein of the non-amyloid beta/A4 protein (A beta) component of Alzheimer disease amyloid, binds A beta and stimulates A beta aggregation Proceedings of the National Academy of Sciences of the United States of America. 92: 9141-9145. PMID 7568089 DOI: 10.1073/Pnas.92.20.9141  0.615
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