Gerardo Morfini - Publications

Affiliations: 
Anatomy and Cell Biology University of Illinois at Chicago (UIC) 

53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Marottoli FM, Priego M, Flores-Barrera E, Pisharody R, Zaldua S, Fan KD, Ekkurthi GK, Brady ST, Morfini GA, Tseng KY, Tai LM. EGF Treatment Improves Motor Behavior and Cortical GABAergic Function in the R6/2 Mouse Model of Huntington's Disease. Molecular Neurobiology. PMID 31104296 DOI: 10.1007/s12035-019-1634-y  0.72
2019 Gatto RG, Ye AQ, Colon-Perez L, Mareci TH, Lysakowski A, Price SD, Brady ST, Karaman M, Morfini G, Magin RL. Detection of axonal degeneration in a mouse model of Huntington's disease: comparison between diffusion tensor imaging and anomalous diffusion metrics. Magma (New York, N.Y.). PMID 30771034 DOI: 10.1007/s10334-019-00742-6  0.72
2017 Zamponi E, Buratti F, Cataldi G, Caicedo HH, Song Y, Jungbauer LM, LaDu MJ, Bisbal M, Lorenzo A, Ma J, Helguera PR, Morfini GA, Brady ST, Pigino GF. Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2. Plos One. 12: e0188340. PMID 29261664 DOI: 10.1371/journal.pone.0188340  0.72
2017 Kneynsberg A, Combs B, Christensen K, Morfini G, Kanaan NM. Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms. Frontiers in Neuroscience. 11: 572. PMID 29089864 DOI: 10.3389/fnins.2017.00572  0.64
2017 Brady ST, Morfini GA. Regulation of motor proteins, axonal transport deficits and adult-onset neurodegenerative diseases. Neurobiology of Disease. PMID 28411118 DOI: 10.1016/j.nbd.2017.04.010  0.72
2017 Leo L, Weissmann C, Burns M, Kang M, Song Y, Qiang L, Brady ST, Baas PW, Morfini G. Mutant spastin proteins promote deficits in axonal transport through an isoform-specific mechanism involving casein kinase 2 activation. Human Molecular Genetics. PMID 28398512 DOI: 10.1093/hmg/ddx125  0.72
2017 Sama RR, Fallini C, Gatto R, McKeon JE, Song Y, Rotunno MS, Penaranda S, Abdurakhmanov I, Landers JE, Morfini G, Brady ST, Bosco DA. ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation. Scientific Reports. 7: 115. PMID 28273913 DOI: 10.1038/s41598-017-00091-1  0.72
2016 Berth SH, Mesnard-Hoaglin N, Wang B, Kim H, Song Y, Sapar M, Morfini G, Brady ST. HIV Glycoprotein Gp120 Impairs Fast Axonal Transport by Activating Tak1 Signaling Pathways. Asn Neuro. 8. PMID 27872270 DOI: 10.1177/1759091416679073  0.72
2016 Cox K, Combs B, Abdelmesih B, Morfini G, Brady ST, Kanaan NM. Analysis of isoform-specific tau aggregates suggests a common toxic mechanism involving similar pathological conformations and axonal transport inhibition. Neurobiology of Aging. 47: 113-126. PMID 27574109 DOI: 10.1016/j.neurobiolaging.2016.07.015  0.72
2016 Tiernan CT, Combs B, Cox K, Morfini G, Brady ST, Counts SE, Kanaan NM. Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport. Experimental Neurology. PMID 27373205 DOI: 10.1016/j.expneurol.2016.06.030  0.72
2016 Morfini G, Schmidt N, Weissman C, Pigino G, Kins S. Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease. Brain Research Bulletin. PMID 27339812 DOI: 10.1016/j.brainresbull.2016.06.009  0.44
2016 Chu Y, Morfini GA, Kordower JH. Alterations in Activity-Dependent Neuroprotective Protein in Sporadic and Experimental Parkinson's Disease. Journal of Parkinson's Disease. PMID 27003787 DOI: 10.3233/JPD-160812  0.72
2016 Song Y, Kang M, Morfini G, Brady ST. Fast axonal transport in isolated axoplasm from the squid giant axon. Methods in Cell Biology. 131: 331-48. PMID 26794522 DOI: 10.1016/bs.mcb.2015.07.004  0.72
2016 Kang M, Baker L, Song Y, Brady ST, Morfini G. Biochemical analysis of axon-specific phosphorylation events using isolated squid axoplasms. Methods in Cell Biology. 131: 199-216. PMID 26794515 DOI: 10.1016/bs.mcb.2015.06.003  0.72
2015 Gatto RG, Chu Y, Ye AQ, Price SD, Tavassoli E, Buenaventura A, Brady ST, Magin RL, Kordower JH, Morfini GA. Analysis of YFP(J16)-R6/2 reporter mice and postmortem brains reveals early pathology and increased vulnerability of callosal axons in Huntington's disease. Human Molecular Genetics. 24: 5285-98. PMID 26123489 DOI: 10.1093/hmg/ddv248  0.72
2015 Berth S, Caicedo HH, Sarma T, Morfini G, Brady ST. Internalization and axonal transport of the HIV glycoprotein gp120. Asn Neuro. 7. PMID 25636314 DOI: 10.1177/1759091414568186  0.72
2013 Morfini GA, Bosco DA, Brown H, Gatto R, Kaminska A, Song Y, Molla L, Baker L, Marangoni MN, Berth S, Tavassoli E, Bagnato C, Tiwari A, Hayward LJ, Pigino GF, et al. Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase. Plos One. 8: e65235. PMID 23776455 DOI: 10.1371/journal.pone.0065235  0.72
2013 Cantuti Castelvetri L, Givogri MI, Hebert A, Smith B, Song Y, Kaminska A, Lopez-Rosas A, Morfini G, Pigino G, Sands M, Brady ST, Bongarzone ER. The sphingolipid psychosine inhibits fast axonal transport in Krabbe disease by activation of GSK3β and deregulation of molecular motors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 10048-56. PMID 23761900 DOI: 10.1523/JNEUROSCI.0217-13.2013  0.72
2013 LaPointe NE, Morfini G, Brady ST, Feinstein SC, Wilson L, Jordan MA. Effects of eribulin, vincristine, paclitaxel and ixabepilone on fast axonal transport and kinesin-1 driven microtubule gliding: implications for chemotherapy-induced peripheral neuropathy. Neurotoxicology. 37: 231-9. PMID 23711742 DOI: 10.1016/j.neuro.2013.05.008  0.72
2013 Kanaan NM, Pigino GF, Brady ST, Lazarov O, Binder LI, Morfini GA. Axonal degeneration in Alzheimer's disease: when signaling abnormalities meet the axonal transport system. Experimental Neurology. 246: 44-53. PMID 22721767 DOI: 10.1016/j.expneurol.2012.06.003  0.72
2012 Chu Y, Morfini GA, Langhamer LB, He Y, Brady ST, Kordower JH. Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease. Brain : a Journal of Neurology. 135: 2058-73. PMID 22719003 DOI: 10.1093/brain/aws133  0.72
2012 Brunholz S, Sisodia S, Lorenzo A, Deyts C, Kins S, Morfini G. Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells. Experimental Brain Research. 217: 353-64. PMID 21960299 DOI: 10.1007/s00221-011-2870-1  0.72
2012 Kanaan NM, Morfini G, Pigino G, LaPointe NE, Andreadis A, Song Y, Leitman E, Binder LI, Brady ST. Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport. Neurobiology of Aging. 33: 826.e15-30. PMID 21794954 DOI: 10.1016/j.neurobiolaging.2011.06.006  0.72
2011 Patterson KR, Ward SM, Combs B, Voss K, Kanaan NM, Morfini G, Brady ST, Gamblin TC, Binder LI. Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport. Biochemistry. 50: 10300-10. PMID 22039833 DOI: 10.1021/bi2009147  0.72
2011 Dráberová E, Vinopal S, Morfini G, Liu PS, Sládková V, Sulimenko T, Burns MR, Solowska J, Kulandaivel K, de Chadarévian JP, Legido A, Mörk SJ, Janáček J, Baas PW, Dráber P, et al. Microtubule-severing ATPase spastin in glioblastoma: increased expression in human glioblastoma cell lines and inverse roles in cell motility and proliferation. Journal of Neuropathology and Experimental Neurology. 70: 811-26. PMID 21865889 DOI: 10.1097/NEN.0b013e31822c256d  0.72
2011 Kanaan NM, Morfini GA, LaPointe NE, Pigino GF, Patterson KR, Song Y, Andreadis A, Fu Y, Brady ST, Binder LI. Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 9858-68. PMID 21734277 DOI: 10.1523/JNEUROSCI.0560-11.2011  0.72
2010 Bosco DA, Morfini G, Karabacak NM, Song Y, Gros-Louis F, Pasinelli P, Goolsby H, Fontaine BA, Lemay N, McKenna-Yasek D, Frosch MP, Agar JN, Julien JP, Brady ST, Brown RH. Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS. Nature Neuroscience. 13: 1396-403. PMID 20953194 DOI: 10.1038/nn.2660  0.72
2010 Brady S, Morfini G. A perspective on neuronal cell death signaling and neurodegeneration Molecular Neurobiology. 42: 25-31. PMID 20480262 DOI: 10.1007/s12035-010-8128-2  0.72
2010 Han I, You Y, Kordower JH, Brady ST, Morfini GA. Differential vulnerability of neurons in Huntington's disease: the role of cell type-specific features. Journal of Neurochemistry. 113: 1073-91. PMID 20236390 DOI: 10.1111/j.1471-4159.2010.06672.x  0.72
2009 Szodorai A, Kuan YH, Hunzelmann S, Engel U, Sakane A, Sasaki T, Takai Y, Kirsch J, Müller U, Beyreuther K, Brady S, Morfini G, Kins S. APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 14534-44. PMID 19923287 DOI: 10.1523/JNEUROSCI.1546-09.2009  0.72
2009 Morfini GA, Burns M, Binder LI, Kanaan NM, LaPointe N, Bosco DA, Brown RH, Brown H, Tiwari A, Hayward L, Edgar J, Nave KA, Garberrn J, Atagi Y, Song Y, et al. Axonal transport defects in neurodegenerative diseases. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12776-86. PMID 19828789 DOI: 10.1523/JNEUROSCI.3463-09.2009  0.72
2009 Morfini GA, You YM, Pollema SL, Kaminska A, Liu K, Yoshioka K, Björkblom B, Coffey ET, Bagnato C, Han D, Huang CF, Banker G, Pigino G, Brady ST. Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin. Nature Neuroscience. 12: 864-71. PMID 19525941 DOI: 10.1038/nn.2346  0.72
2009 Berth SH, Leopold PL, Morfini GN. Virus-induced neuronal dysfunction and degeneration. Frontiers in Bioscience (Landmark Edition). 14: 5239-59. PMID 19482613  0.4
2009 LaPointe NE, Morfini G, Pigino G, Gaisina IN, Kozikowski AP, Binder LI, Brady ST. The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity. Journal of Neuroscience Research. 87: 440-51. PMID 18798283 DOI: 10.1002/jnr.21850  0.72
2008 DeBoer SR, You Y, Szodorai A, Kaminska A, Pigino G, Nwabuisi E, Wang B, Estrada-Hernandez T, Kins S, Brady ST, Morfini G. Conventional kinesin holoenzymes are composed of heavy and light chain homodimers. Biochemistry. 47: 4535-43. PMID 18361505 DOI: 10.1021/bi702445j  0.72
2008 Solowska JM, Morfini G, Falnikar A, Himes BT, Brady ST, Huang D, Baas PW. Quantitative and functional analyses of spastin in the nervous system: implications for hereditary spastic paraplegia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 2147-57. PMID 18305248 DOI: 10.1523/JNEUROSCI.3159-07.2008  0.72
2007 Morfini G, Pigino G, Brady ST. Approaches to kinesin-1 phosphorylation. Methods in Molecular Biology (Clifton, N.J.). 392: 51-69. PMID 17951710 DOI: 10.1007/978-1-59745-490-2_4  0.72
2007 Lazarov O, Morfini GA, Pigino G, Gadadhar A, Chen X, Robinson J, Ho H, Brady ST, Sisodia SS. Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 7011-20. PMID 17596450 DOI: 10.1523/JNEUROSCI.4272-06.2007  0.72
2007 Serulle Y, Morfini G, Pigino G, Moreira JE, Sugimori M, Brady ST, Llinás RR. 1-Methyl-4-phenylpyridinium induces synaptic dysfunction through a pathway involving caspase and PKCdelta enzymatic activities. Proceedings of the National Academy of Sciences of the United States of America. 104: 2437-41. PMID 17287339 DOI: 10.1073/pnas.0611227104  0.72
2007 Morfini G, Pigino G, Mizuno N, Kikkawa M, Brady ST. Tau binding to microtubules does not directly affect microtubule-based vesicle motility. Journal of Neuroscience Research. 85: 2620-30. PMID 17265463 DOI: 10.1002/jnr.21154  0.72
2006 Morfini G, Pigino G, Szebenyi G, You Y, Pollema S, Brady ST. JNK mediates pathogenic effects of polyglutamine-expanded androgen receptor on fast axonal transport. Nature Neuroscience. 9: 907-16. PMID 16751763 DOI: 10.1038/nn1717  0.72
2005 Lazarov O, Morfini GA, Lee EB, Farah MH, Szodorai A, DeBoer SR, Koliatsos VE, Kins S, Lee VM, Wong PC, Price DL, Brady ST, Sisodia SS. Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2386-95. PMID 15745965 DOI: 10.1523/JNEUROSCI.3089-04.2005  0.72
2005 Morfini G, Pigino G, Brady ST. Polyglutamine expansion diseases: failing to deliver. Trends in Molecular Medicine. 11: 64-70. PMID 15694868 DOI: 10.1016/j.molmed.2004.12.002  0.72
2004 Morfini G, Szebenyi G, Brown H, Pant HC, Pigino G, DeBoer S, Beffert U, Brady ST. A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons. The Embo Journal. 23: 2235-45. PMID 15152189 DOI: 10.1038/sj.emboj.7600237  0.72
2004 Beffert U, Weeber EJ, Morfini G, Ko J, Brady ST, Tsai LH, Sweatt JD, Herz J. Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 1897-906. PMID 14985430 DOI: 10.1523/JNEUROSCI.4084-03.2004  0.72
2003 Szebenyi G, Morfini GA, Babcock A, Gould M, Selkoe K, Stenoien DL, Young M, Faber PW, MacDonald ME, McPhaul MJ, Brady ST. Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport. Neuron. 40: 41-52. PMID 14527432 DOI: 10.1016/S0896-6273(03)00569-5  0.72
2003 Pigino G, Morfini G, Pelsman A, Mattson MP, Brady ST, Busciglio J. Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4499-508. PMID 12805290  0.72
2003 Pfenninger KH, Laurino L, Peretti D, Wang X, Rosso S, Morfini G, Cáceres A, Quiroga S. Regulation of membrane expansion at the nerve growth cone. Journal of Cell Science. 116: 1209-17. PMID 12615964 DOI: 10.1242/jcs.00285  0.72
2002 Morfini G, Pigino G, Beffert U, Busciglio J, Brady ST. Fast axonal transport misregulation and Alzheimer's disease. Neuromolecular Medicine. 2: 89-99. PMID 12428805 DOI: 10.1385/NMM:2:2:089  0.72
2002 Beffert U, Morfini G, Bock HH, Reyna H, Brady ST, Herz J. Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta. The Journal of Biological Chemistry. 277: 49958-64. PMID 12376533 DOI: 10.1074/jbc.M209205200  0.72
2002 Szebenyi G, Morfini G, Brady ST. Pictures in cell biology. GSK-3 and regulation of kinesin function. Trends in Cell Biology. 12: 245. PMID 12062174 DOI: 10.1016/S0962-8924(02)02283-3  0.72
2002 Donelan MJ, Morfini G, Julyan R, Sommers S, Hays L, Kajio H, Briaud I, Easom RA, Molkentin JD, Brady ST, Rhodes CJ. Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis. The Journal of Biological Chemistry. 277: 24232-42. PMID 11978799 DOI: 10.1074/jbc.M203345200  0.72
2002 Morfini G, Szebenyi G, Elluru R, Ratner N, Brady ST. Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility. The Embo Journal. 21: 281-93. PMID 11823421 DOI: 10.1093/emboj/21.3.281  0.72
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