Year |
Citation |
Score |
2023 |
König S, Schmidt N, Bechberger K, Morris S, Priego M, Zaky H, Song Y, Pielage J, Brunholz S, Brady ST, Kins S, Morfini G. Axon-Autonomous Effects of the Amyloid Precursor Protein Intracellular Domain (AICD) on Kinase Signaling and Fast Axonal Transport. Cells. 12. PMID 37830617 DOI: 10.3390/cells12192403 |
0.558 |
|
2023 |
Song Y, Tsai MY, Wang B, Comassio P, Moreira JE, Kriefall N, Morfini G, Brady S. Divergent Molecular Pathways for Toxicity of Selected Mutant C9ORF72-derived Dipeptide Repeats. Biorxiv : the Preprint Server For Biology. PMID 37808871 DOI: 10.1101/2023.09.28.558663 |
0.43 |
|
2023 |
Brady ST, Mesnard-Hoaglin NA, Priego M, Dziechciowska J, Morris S, Kang M, Tsai MY, Purks JL, Klein A, Gaona A, Melloni A, Connors T, Hyman B, Song Y, Morfini GA. Toxic effects of mutant huntingtin in axons are mediated by its proline-rich domain. Brain : a Journal of Neurology. PMID 37633260 DOI: 10.1093/brain/awad280 |
0.488 |
|
2023 |
Morfini G, Kins S. Editorial: Kinase/phosphatase signaling and axonal function in health and disease. Frontiers in Cellular Neuroscience. 17: 1172836. PMID 37032835 DOI: 10.3389/fncel.2023.1172836 |
0.375 |
|
2021 |
Piermarini E, Akarsu S, Connors T, Kneussel M, Lane MA, Morfini G, Karabay A, Baas PW, Qiang L. Modeling gain-of-function and loss-of-function components of SPAST-based hereditary spastic paraplegia using transgenic mice. Human Molecular Genetics. PMID 34935948 DOI: 10.1093/hmg/ddab367 |
0.398 |
|
2021 |
Combs B, Christensen KR, Richards C, Kneynsberg A, Mueller RL, Morris SL, Morfini G, Brady ST, Kanaan NM. FTLD mutant tau impairs axonal transport through a protein phosphatase 1γ-dependent mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 34607969 DOI: 10.1523/JNEUROSCI.1914-20.2021 |
0.754 |
|
2021 |
Richards A, Berth SH, Brady S, Morfini G. Engagement of Neurotropic Viruses in Fast Axonal Transport: Mechanisms, Potential Role of Host Kinases and Implications for Neuronal Dysfunction. Frontiers in Cellular Neuroscience. 15: 684762. PMID 34234649 DOI: 10.3389/fncel.2021.684762 |
0.415 |
|
2021 |
Mueller RL, Combs B, Alhadidy MM, Brady ST, Morfini GA, Kanaan NM. Tau: A Signaling Hub Protein. Frontiers in Molecular Neuroscience. 14: 647054. PMID 33815057 DOI: 10.3389/fnmol.2021.647054 |
0.69 |
|
2020 |
Morris SL, Tsai MY, Aloe S, Bechberger K, König S, Morfini G, Brady ST. Defined Tau Phosphospecies Differentially Inhibit Fast Axonal Transport Through Activation of Two Independent Signaling Pathways. Frontiers in Molecular Neuroscience. 13: 610037. PMID 33568975 DOI: 10.3389/fnmol.2020.610037 |
0.517 |
|
2019 |
Combs B, Mueller RL, Morfini G, Brady ST, Kanaan NM. Tau and Axonal Transport Misregulation in Tauopathies. Advances in Experimental Medicine and Biology. 1184: 81-95. PMID 32096030 DOI: 10.1007/978-981-32-9358-8_7 |
0.746 |
|
2019 |
Marottoli FM, Priego M, Flores-Barrera E, Pisharody R, Zaldua S, Fan KD, Ekkurthi GK, Brady ST, Morfini GA, Tseng KY, Tai LM. EGF Treatment Improves Motor Behavior and Cortical GABAergic Function in the R6/2 Mouse Model of Huntington's Disease. Molecular Neurobiology. PMID 31104296 DOI: 10.1007/S12035-019-1634-Y |
0.484 |
|
2019 |
Gatto RG, Ye AQ, Colon-Perez L, Mareci TH, Lysakowski A, Price SD, Brady ST, Karaman M, Morfini G, Magin RL. Detection of axonal degeneration in a mouse model of Huntington's disease: comparison between diffusion tensor imaging and anomalous diffusion metrics. Magma (New York, N.Y.). PMID 30771034 DOI: 10.1007/S10334-019-00742-6 |
0.343 |
|
2018 |
Qiang L, Piermarini E, Muralidharan H, Yu W, Leo L, Hennessy LE, Fernandes S, Connors T, Yates PL, Swift M, Zholudeva LV, Lane MA, Morfini G, Alexander GM, Heiman-Patterson TD, et al. Hereditary Spastic Paraplegia: gain-of-function mechanisms revealed by new transgenic mouse. Human Molecular Genetics. PMID 30520996 DOI: 10.1093/Hmg/Ddy419 |
0.485 |
|
2017 |
Zamponi E, Buratti F, Cataldi G, Caicedo HH, Song Y, Jungbauer LM, LaDu MJ, Bisbal M, Lorenzo A, Ma J, Helguera PR, Morfini GA, Brady ST, Pigino GF. Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2. Plos One. 12: e0188340. PMID 29261664 DOI: 10.1371/Journal.Pone.0188340 |
0.499 |
|
2017 |
Kneynsberg A, Combs B, Christensen K, Morfini G, Kanaan NM. Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms. Frontiers in Neuroscience. 11: 572. PMID 29089864 DOI: 10.3389/Fnins.2017.00572 |
0.755 |
|
2017 |
Brady ST, Morfini GA. Regulation of motor proteins, axonal transport deficits and adult-onset neurodegenerative diseases. Neurobiology of Disease. PMID 28411118 DOI: 10.1016/J.Nbd.2017.04.010 |
0.475 |
|
2017 |
Leo L, Weissmann C, Burns M, Kang M, Song Y, Qiang L, Brady ST, Baas PW, Morfini G. Mutant spastin proteins promote deficits in axonal transport through an isoform-specific mechanism involving casein kinase 2 activation. Human Molecular Genetics. PMID 28398512 DOI: 10.1093/Hmg/Ddx125 |
0.471 |
|
2017 |
Sama RR, Fallini C, Gatto R, McKeon JE, Song Y, Rotunno MS, Penaranda S, Abdurakhmanov I, Landers JE, Morfini G, Brady ST, Bosco DA. ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation. Scientific Reports. 7: 115. PMID 28273913 DOI: 10.1038/S41598-017-00091-1 |
0.502 |
|
2017 |
Stern JL, Lessard DV, Hoeprich GJ, Morfini GA, Berger CL. Phospho-regulation of tau modulates inhibition of kinesin-1 motility. Molecular Biology of the Cell. PMID 28251926 DOI: 10.1091/mbc.E16-10-0728 |
0.51 |
|
2016 |
Berth SH, Mesnard-Hoaglin N, Wang B, Kim H, Song Y, Sapar M, Morfini G, Brady ST. HIV Glycoprotein Gp120 Impairs Fast Axonal Transport by Activating Tak1 Signaling Pathways. Asn Neuro. 8. PMID 27872270 DOI: 10.1177/1759091416679073 |
0.463 |
|
2016 |
Cox K, Combs B, Abdelmesih B, Morfini G, Brady ST, Kanaan NM. Analysis of isoform-specific tau aggregates suggests a common toxic mechanism involving similar pathological conformations and axonal transport inhibition. Neurobiology of Aging. 47: 113-126. PMID 27574109 DOI: 10.1016/J.Neurobiolaging.2016.07.015 |
0.718 |
|
2016 |
Tiernan CT, Combs B, Cox K, Morfini G, Brady ST, Counts SE, Kanaan NM. Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport. Experimental Neurology. PMID 27373205 DOI: 10.1016/J.Expneurol.2016.06.030 |
0.731 |
|
2016 |
Morfini G, Schmidt N, Weissman C, Pigino G, Kins S. Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease. Brain Research Bulletin. PMID 27339812 DOI: 10.1016/j.brainresbull.2016.06.009 |
0.403 |
|
2016 |
Song Y, Kang M, Morfini G, Brady ST. Fast axonal transport in isolated axoplasm from the squid giant axon. Methods in Cell Biology. 131: 331-48. PMID 26794522 DOI: 10.1016/Bs.Mcb.2015.07.004 |
0.502 |
|
2016 |
Kang M, Baker L, Song Y, Brady ST, Morfini G. Biochemical analysis of axon-specific phosphorylation events using isolated squid axoplasms. Methods in Cell Biology. 131: 199-216. PMID 26794515 DOI: 10.1016/Bs.Mcb.2015.06.003 |
0.576 |
|
2015 |
Gatto RG, Chu Y, Ye AQ, Price SD, Tavassoli E, Buenaventura A, Brady ST, Magin RL, Kordower JH, Morfini GA. Analysis of YFP(J16)-R6/2 reporter mice and postmortem brains reveals early pathology and increased vulnerability of callosal axons in Huntington's disease. Human Molecular Genetics. 24: 5285-98. PMID 26123489 DOI: 10.1093/Hmg/Ddv248 |
0.458 |
|
2015 |
Berth S, Caicedo HH, Sarma T, Morfini G, Brady ST. Internalization and axonal transport of the HIV glycoprotein gp120. Asn Neuro. 7. PMID 25636314 DOI: 10.1177/1759091414568186 |
0.405 |
|
2015 |
Parsi S, Pandamooz S, Heidari S, Naji M, Morfini G, Ahmadiani A, Dargahi L. A novel rat model of Alzheimer's disease based on lentiviral-mediated expression of mutant APP. Neuroscience. 284: 99-106. PMID 25270904 DOI: 10.1016/J.Neuroscience.2014.09.045 |
0.396 |
|
2015 |
Redmond M, Hoeprich G, Pantalia M, Morfini G, Berger C. Regulation of Tau Dynamics by Phosphorylation in the Squid Giant Axon Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.2458 |
0.557 |
|
2013 |
Morfini GA, Bosco DA, Brown H, Gatto R, Kaminska A, Song Y, Molla L, Baker L, Marangoni MN, Berth S, Tavassoli E, Bagnato C, Tiwari A, Hayward LJ, Pigino GF, et al. Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase. Plos One. 8: e65235. PMID 23776455 DOI: 10.1371/Journal.Pone.0065235 |
0.477 |
|
2013 |
Cantuti Castelvetri L, Givogri MI, Hebert A, Smith B, Song Y, Kaminska A, Lopez-Rosas A, Morfini G, Pigino G, Sands M, Brady ST, Bongarzone ER. The sphingolipid psychosine inhibits fast axonal transport in Krabbe disease by activation of GSK3β and deregulation of molecular motors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 10048-56. PMID 23761900 DOI: 10.1523/Jneurosci.0217-13.2013 |
0.578 |
|
2013 |
Bignante EA, Heredia F, Morfini G, Lorenzo A. Amyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's disease. Neurobiology of Aging. 34: 2525-37. PMID 23714735 DOI: 10.1016/J.Neurobiolaging.2013.04.021 |
0.479 |
|
2013 |
LaPointe NE, Morfini G, Brady ST, Feinstein SC, Wilson L, Jordan MA. Effects of eribulin, vincristine, paclitaxel and ixabepilone on fast axonal transport and kinesin-1 driven microtubule gliding: implications for chemotherapy-induced peripheral neuropathy. Neurotoxicology. 37: 231-9. PMID 23711742 DOI: 10.1016/J.Neuro.2013.05.008 |
0.464 |
|
2013 |
Kanaan NM, Pigino GF, Brady ST, Lazarov O, Binder LI, Morfini GA. Axonal degeneration in Alzheimer's disease: when signaling abnormalities meet the axonal transport system. Experimental Neurology. 246: 44-53. PMID 22721767 DOI: 10.1016/J.Expneurol.2012.06.003 |
0.722 |
|
2013 |
Hennigan RF, Moon CA, Parysek LM, Monk KR, Morfini G, Berth S, Brady S, Ratner N. The NF2 tumor suppressor regulates microtubule-based vesicle trafficking via a novel Rac, MLK and p38(SAPK) pathway. Oncogene. 32: 1135-43. PMID 22525268 DOI: 10.1038/Onc.2012.135 |
0.377 |
|
2012 |
Chu Y, Morfini GA, Langhamer LB, He Y, Brady ST, Kordower JH. Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease. Brain : a Journal of Neurology. 135: 2058-73. PMID 22719003 DOI: 10.1093/Brain/Aws133 |
0.438 |
|
2012 |
Brunholz S, Sisodia S, Lorenzo A, Deyts C, Kins S, Morfini G. Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells. Experimental Brain Research. 217: 353-64. PMID 21960299 DOI: 10.1007/S00221-011-2870-1 |
0.521 |
|
2012 |
Kanaan NM, Morfini G, Pigino G, LaPointe NE, Andreadis A, Song Y, Leitman E, Binder LI, Brady ST. Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport. Neurobiology of Aging. 33: 826.e15-30. PMID 21794954 DOI: 10.1016/J.Neurobiolaging.2011.06.006 |
0.727 |
|
2011 |
Patterson KR, Ward SM, Combs B, Voss K, Kanaan NM, Morfini G, Brady ST, Gamblin TC, Binder LI. Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport. Biochemistry. 50: 10300-10. PMID 22039833 DOI: 10.1021/Bi2009147 |
0.712 |
|
2011 |
Kanaan NM, Morfini GA, LaPointe NE, Pigino GF, Patterson KR, Song Y, Andreadis A, Fu Y, Brady ST, Binder LI. Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 9858-68. PMID 21734277 DOI: 10.1523/Jneurosci.0560-11.2011 |
0.76 |
|
2011 |
Smith JA, LaPointe N, Morfini G, Brady S, Feinstein S, Wilson L, Jordan MA. Abstract C213: Eribulin, vincristine, ixabepilone, and paclitaxel inhibit neuronal cell function by varied mechanisms and to varying degrees. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-C213 |
0.484 |
|
2010 |
Brady S, Morfini G. A perspective on neuronal cell death signaling and neurodegeneration Molecular Neurobiology. 42: 25-31. PMID 20480262 DOI: 10.1007/S12035-010-8128-2 |
0.388 |
|
2010 |
Kins S, Hunzelmann S, Szodorai A, Kuan Y, Engel U, Müller U, Beyreuther K, Brady S, Morfini G. Assembly of APP anterograde transport vesicles Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.316 |
0.362 |
|
2009 |
Szodorai A, Kuan YH, Hunzelmann S, Engel U, Sakane A, Sasaki T, Takai Y, Kirsch J, Müller U, Beyreuther K, Brady S, Morfini G, Kins S. APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 14534-44. PMID 19923287 DOI: 10.1523/Jneurosci.1546-09.2009 |
0.432 |
|
2009 |
Morfini GA, Burns M, Binder LI, Kanaan NM, LaPointe N, Bosco DA, Brown RH, Brown H, Tiwari A, Hayward L, Edgar J, Nave KA, Garberrn J, Atagi Y, Song Y, et al. Axonal transport defects in neurodegenerative diseases. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12776-86. PMID 19828789 DOI: 10.1523/Jneurosci.3463-09.2009 |
0.702 |
|
2009 |
Morfini GA, You YM, Pollema SL, Kaminska A, Liu K, Yoshioka K, Björkblom B, Coffey ET, Bagnato C, Han D, Huang CF, Banker G, Pigino G, Brady ST. Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin. Nature Neuroscience. 12: 864-71. PMID 19525941 DOI: 10.1038/Nn.2346 |
0.526 |
|
2009 |
LaPointe NE, Morfini G, Pigino G, Gaisina IN, Kozikowski AP, Binder LI, Brady ST. The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity. Journal of Neuroscience Research. 87: 440-51. PMID 18798283 DOI: 10.1002/Jnr.21850 |
0.539 |
|
2008 |
DeBoer SR, You Y, Szodorai A, Kaminska A, Pigino G, Nwabuisi E, Wang B, Estrada-Hernandez T, Kins S, Brady ST, Morfini G. Conventional kinesin holoenzymes are composed of heavy and light chain homodimers. Biochemistry. 47: 4535-43. PMID 18361505 DOI: 10.1021/Bi702445J |
0.442 |
|
2008 |
Solowska JM, Morfini G, Falnikar A, Himes BT, Brady ST, Huang D, Baas PW. Quantitative and functional analyses of spastin in the nervous system: implications for hereditary spastic paraplegia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 2147-57. PMID 18305248 DOI: 10.1523/Jneurosci.3159-07.2008 |
0.421 |
|
2007 |
Morfini G, Pigino G, Brady ST. Approaches to kinesin-1 phosphorylation. Methods in Molecular Biology (Clifton, N.J.). 392: 51-69. PMID 17951710 DOI: 10.1007/978-1-59745-490-2_4 |
0.357 |
|
2007 |
Lazarov O, Morfini GA, Pigino G, Gadadhar A, Chen X, Robinson J, Ho H, Brady ST, Sisodia SS. Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 7011-20. PMID 17596450 DOI: 10.1523/Jneurosci.4272-06.2007 |
0.47 |
|
2007 |
Morfini G, Pigino G, Opalach K, Serulle Y, Moreira JE, Sugimori M, Llinás RR, Brady ST. 1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C. Proceedings of the National Academy of Sciences of the United States of America. 104: 2442-7. PMID 17287338 DOI: 10.1073/Pnas.0611231104 |
0.483 |
|
2007 |
Morfini G, Pigino G, Mizuno N, Kikkawa M, Brady ST. Tau binding to microtubules does not directly affect microtubule-based vesicle motility. Journal of Neuroscience Research. 85: 2620-30. PMID 17265463 DOI: 10.1002/Jnr.21154 |
0.535 |
|
2006 |
Morfini G, Pigino G, Szebenyi G, You Y, Pollema S, Brady ST. JNK mediates pathogenic effects of polyglutamine-expanded androgen receptor on fast axonal transport. Nature Neuroscience. 9: 907-16. PMID 16751763 DOI: 10.1038/Nn1717 |
0.512 |
|
2005 |
Lazarov O, Morfini GA, Lee EB, Farah MH, Szodorai A, DeBoer SR, Koliatsos VE, Kins S, Lee VM, Wong PC, Price DL, Brady ST, Sisodia SS. Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2386-95. PMID 15745965 DOI: 10.1523/Jneurosci.3089-04.2005 |
0.404 |
|
2005 |
Morfini G, Pigino G, Brady ST. Polyglutamine expansion diseases: failing to deliver. Trends in Molecular Medicine. 11: 64-70. PMID 15694868 DOI: 10.1016/J.Molmed.2004.12.002 |
0.501 |
|
2004 |
Morfini G, Szebenyi G, Brown H, Pant HC, Pigino G, DeBoer S, Beffert U, Brady ST. A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons. The Embo Journal. 23: 2235-45. PMID 15152189 DOI: 10.1038/Sj.Emboj.7600237 |
0.592 |
|
2004 |
Beffert U, Weeber EJ, Morfini G, Ko J, Brady ST, Tsai LH, Sweatt JD, Herz J. Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 1897-906. PMID 14985430 DOI: 10.1523/Jneurosci.4084-03.2004 |
0.372 |
|
2003 |
Szebenyi G, Morfini GA, Babcock A, Gould M, Selkoe K, Stenoien DL, Young M, Faber PW, MacDonald ME, McPhaul MJ, Brady ST. Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport. Neuron. 40: 41-52. PMID 14527432 DOI: 10.1016/S0896-6273(03)00569-5 |
0.503 |
|
2003 |
Pigino G, Morfini G, Pelsman A, Mattson MP, Brady ST, Busciglio J. Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4499-508. PMID 12805290 DOI: 10.1523/Jneurosci.23-11-04499.2003 |
0.516 |
|
2002 |
Morfini G, Pigino G, Beffert U, Busciglio J, Brady ST. Fast axonal transport misregulation and Alzheimer's disease. Neuromolecular Medicine. 2: 89-99. PMID 12428805 DOI: 10.1385/Nmm:2:2:089 |
0.539 |
|
2002 |
Szebenyi G, Morfini G, Brady ST. Pictures in cell biology. GSK-3 and regulation of kinesin function. Trends in Cell Biology. 12: 245. PMID 12062174 DOI: 10.1016/S0962-8924(02)02283-3 |
0.315 |
|
2002 |
Morfini G, Szebenyi G, Elluru R, Ratner N, Brady ST. Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility. The Embo Journal. 21: 281-93. PMID 11823421 DOI: 10.1093/Emboj/21.3.281 |
0.441 |
|
1998 |
Paglini G, Pigino G, Kunda P, Morfini G, Maccioni R, Quiroga S, Ferreira A, Cáceres A. Evidence for the participation of the neuron-specific CDK5 activator p35 during laminin-enhanced axonal growth Journal of Neuroscience. 18: 9858-9869. PMID 9822744 DOI: 10.1523/Jneurosci.18-23-09858.1998 |
0.418 |
|
1995 |
Morfini G, DiTella MC, Feiguin F, Carri N, Cáceres A. Neurotrophin-3 enhances neurite outgrowth in cultured hippocampal pyramidal neurons. Journal of Neuroscience Research. 39: 219-32. PMID 7837290 DOI: 10.1002/JNR.490390212 |
0.361 |
|
1995 |
DiTella M, Feiguin F, Morfini G, Cáceres A. Microfilament-associated growth cone component depends upon Tau for its intracellular localization. Cell Motility and the Cytoskeleton. 29: 117-30. PMID 7820862 DOI: 10.1002/CM.970290204 |
0.353 |
|
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