Gerardo Morfini - Publications

Affiliations: 
Anatomy and Cell Biology University of Illinois at Chicago, Chicago, IL, United States 

66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 König S, Schmidt N, Bechberger K, Morris S, Priego M, Zaky H, Song Y, Pielage J, Brunholz S, Brady ST, Kins S, Morfini G. Axon-Autonomous Effects of the Amyloid Precursor Protein Intracellular Domain (AICD) on Kinase Signaling and Fast Axonal Transport. Cells. 12. PMID 37830617 DOI: 10.3390/cells12192403  0.558
2023 Song Y, Tsai MY, Wang B, Comassio P, Moreira JE, Kriefall N, Morfini G, Brady S. Divergent Molecular Pathways for Toxicity of Selected Mutant C9ORF72-derived Dipeptide Repeats. Biorxiv : the Preprint Server For Biology. PMID 37808871 DOI: 10.1101/2023.09.28.558663  0.43
2023 Brady ST, Mesnard-Hoaglin NA, Priego M, Dziechciowska J, Morris S, Kang M, Tsai MY, Purks JL, Klein A, Gaona A, Melloni A, Connors T, Hyman B, Song Y, Morfini GA. Toxic effects of mutant huntingtin in axons are mediated by its proline-rich domain. Brain : a Journal of Neurology. PMID 37633260 DOI: 10.1093/brain/awad280  0.488
2023 Morfini G, Kins S. Editorial: Kinase/phosphatase signaling and axonal function in health and disease. Frontiers in Cellular Neuroscience. 17: 1172836. PMID 37032835 DOI: 10.3389/fncel.2023.1172836  0.375
2021 Piermarini E, Akarsu S, Connors T, Kneussel M, Lane MA, Morfini G, Karabay A, Baas PW, Qiang L. Modeling gain-of-function and loss-of-function components of SPAST-based hereditary spastic paraplegia using transgenic mice. Human Molecular Genetics. PMID 34935948 DOI: 10.1093/hmg/ddab367  0.398
2021 Combs B, Christensen KR, Richards C, Kneynsberg A, Mueller RL, Morris SL, Morfini G, Brady ST, Kanaan NM. FTLD mutant tau impairs axonal transport through a protein phosphatase 1γ-dependent mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 34607969 DOI: 10.1523/JNEUROSCI.1914-20.2021  0.754
2021 Richards A, Berth SH, Brady S, Morfini G. Engagement of Neurotropic Viruses in Fast Axonal Transport: Mechanisms, Potential Role of Host Kinases and Implications for Neuronal Dysfunction. Frontiers in Cellular Neuroscience. 15: 684762. PMID 34234649 DOI: 10.3389/fncel.2021.684762  0.415
2021 Mueller RL, Combs B, Alhadidy MM, Brady ST, Morfini GA, Kanaan NM. Tau: A Signaling Hub Protein. Frontiers in Molecular Neuroscience. 14: 647054. PMID 33815057 DOI: 10.3389/fnmol.2021.647054  0.69
2020 Morris SL, Tsai MY, Aloe S, Bechberger K, König S, Morfini G, Brady ST. Defined Tau Phosphospecies Differentially Inhibit Fast Axonal Transport Through Activation of Two Independent Signaling Pathways. Frontiers in Molecular Neuroscience. 13: 610037. PMID 33568975 DOI: 10.3389/fnmol.2020.610037  0.517
2019 Combs B, Mueller RL, Morfini G, Brady ST, Kanaan NM. Tau and Axonal Transport Misregulation in Tauopathies. Advances in Experimental Medicine and Biology. 1184: 81-95. PMID 32096030 DOI: 10.1007/978-981-32-9358-8_7  0.746
2019 Marottoli FM, Priego M, Flores-Barrera E, Pisharody R, Zaldua S, Fan KD, Ekkurthi GK, Brady ST, Morfini GA, Tseng KY, Tai LM. EGF Treatment Improves Motor Behavior and Cortical GABAergic Function in the R6/2 Mouse Model of Huntington's Disease. Molecular Neurobiology. PMID 31104296 DOI: 10.1007/S12035-019-1634-Y  0.484
2019 Gatto RG, Ye AQ, Colon-Perez L, Mareci TH, Lysakowski A, Price SD, Brady ST, Karaman M, Morfini G, Magin RL. Detection of axonal degeneration in a mouse model of Huntington's disease: comparison between diffusion tensor imaging and anomalous diffusion metrics. Magma (New York, N.Y.). PMID 30771034 DOI: 10.1007/S10334-019-00742-6  0.343
2018 Qiang L, Piermarini E, Muralidharan H, Yu W, Leo L, Hennessy LE, Fernandes S, Connors T, Yates PL, Swift M, Zholudeva LV, Lane MA, Morfini G, Alexander GM, Heiman-Patterson TD, et al. Hereditary Spastic Paraplegia: gain-of-function mechanisms revealed by new transgenic mouse. Human Molecular Genetics. PMID 30520996 DOI: 10.1093/Hmg/Ddy419  0.485
2017 Zamponi E, Buratti F, Cataldi G, Caicedo HH, Song Y, Jungbauer LM, LaDu MJ, Bisbal M, Lorenzo A, Ma J, Helguera PR, Morfini GA, Brady ST, Pigino GF. Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2. Plos One. 12: e0188340. PMID 29261664 DOI: 10.1371/Journal.Pone.0188340  0.499
2017 Kneynsberg A, Combs B, Christensen K, Morfini G, Kanaan NM. Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms. Frontiers in Neuroscience. 11: 572. PMID 29089864 DOI: 10.3389/Fnins.2017.00572  0.755
2017 Brady ST, Morfini GA. Regulation of motor proteins, axonal transport deficits and adult-onset neurodegenerative diseases. Neurobiology of Disease. PMID 28411118 DOI: 10.1016/J.Nbd.2017.04.010  0.475
2017 Leo L, Weissmann C, Burns M, Kang M, Song Y, Qiang L, Brady ST, Baas PW, Morfini G. Mutant spastin proteins promote deficits in axonal transport through an isoform-specific mechanism involving casein kinase 2 activation. Human Molecular Genetics. PMID 28398512 DOI: 10.1093/Hmg/Ddx125  0.471
2017 Sama RR, Fallini C, Gatto R, McKeon JE, Song Y, Rotunno MS, Penaranda S, Abdurakhmanov I, Landers JE, Morfini G, Brady ST, Bosco DA. ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation. Scientific Reports. 7: 115. PMID 28273913 DOI: 10.1038/S41598-017-00091-1  0.502
2017 Stern JL, Lessard DV, Hoeprich GJ, Morfini GA, Berger CL. Phospho-regulation of tau modulates inhibition of kinesin-1 motility. Molecular Biology of the Cell. PMID 28251926 DOI: 10.1091/mbc.E16-10-0728  0.51
2016 Berth SH, Mesnard-Hoaglin N, Wang B, Kim H, Song Y, Sapar M, Morfini G, Brady ST. HIV Glycoprotein Gp120 Impairs Fast Axonal Transport by Activating Tak1 Signaling Pathways. Asn Neuro. 8. PMID 27872270 DOI: 10.1177/1759091416679073  0.463
2016 Cox K, Combs B, Abdelmesih B, Morfini G, Brady ST, Kanaan NM. Analysis of isoform-specific tau aggregates suggests a common toxic mechanism involving similar pathological conformations and axonal transport inhibition. Neurobiology of Aging. 47: 113-126. PMID 27574109 DOI: 10.1016/J.Neurobiolaging.2016.07.015  0.718
2016 Tiernan CT, Combs B, Cox K, Morfini G, Brady ST, Counts SE, Kanaan NM. Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport. Experimental Neurology. PMID 27373205 DOI: 10.1016/J.Expneurol.2016.06.030  0.731
2016 Morfini G, Schmidt N, Weissman C, Pigino G, Kins S. Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease. Brain Research Bulletin. PMID 27339812 DOI: 10.1016/j.brainresbull.2016.06.009  0.403
2016 Song Y, Kang M, Morfini G, Brady ST. Fast axonal transport in isolated axoplasm from the squid giant axon. Methods in Cell Biology. 131: 331-48. PMID 26794522 DOI: 10.1016/Bs.Mcb.2015.07.004  0.502
2016 Kang M, Baker L, Song Y, Brady ST, Morfini G. Biochemical analysis of axon-specific phosphorylation events using isolated squid axoplasms. Methods in Cell Biology. 131: 199-216. PMID 26794515 DOI: 10.1016/Bs.Mcb.2015.06.003  0.576
2015 Gatto RG, Chu Y, Ye AQ, Price SD, Tavassoli E, Buenaventura A, Brady ST, Magin RL, Kordower JH, Morfini GA. Analysis of YFP(J16)-R6/2 reporter mice and postmortem brains reveals early pathology and increased vulnerability of callosal axons in Huntington's disease. Human Molecular Genetics. 24: 5285-98. PMID 26123489 DOI: 10.1093/Hmg/Ddv248  0.458
2015 Berth S, Caicedo HH, Sarma T, Morfini G, Brady ST. Internalization and axonal transport of the HIV glycoprotein gp120. Asn Neuro. 7. PMID 25636314 DOI: 10.1177/1759091414568186  0.405
2015 Parsi S, Pandamooz S, Heidari S, Naji M, Morfini G, Ahmadiani A, Dargahi L. A novel rat model of Alzheimer's disease based on lentiviral-mediated expression of mutant APP. Neuroscience. 284: 99-106. PMID 25270904 DOI: 10.1016/J.Neuroscience.2014.09.045  0.396
2015 Redmond M, Hoeprich G, Pantalia M, Morfini G, Berger C. Regulation of Tau Dynamics by Phosphorylation in the Squid Giant Axon Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.2458  0.557
2013 Morfini GA, Bosco DA, Brown H, Gatto R, Kaminska A, Song Y, Molla L, Baker L, Marangoni MN, Berth S, Tavassoli E, Bagnato C, Tiwari A, Hayward LJ, Pigino GF, et al. Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase. Plos One. 8: e65235. PMID 23776455 DOI: 10.1371/Journal.Pone.0065235  0.477
2013 Cantuti Castelvetri L, Givogri MI, Hebert A, Smith B, Song Y, Kaminska A, Lopez-Rosas A, Morfini G, Pigino G, Sands M, Brady ST, Bongarzone ER. The sphingolipid psychosine inhibits fast axonal transport in Krabbe disease by activation of GSK3β and deregulation of molecular motors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 10048-56. PMID 23761900 DOI: 10.1523/Jneurosci.0217-13.2013  0.578
2013 Bignante EA, Heredia F, Morfini G, Lorenzo A. Amyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's disease. Neurobiology of Aging. 34: 2525-37. PMID 23714735 DOI: 10.1016/J.Neurobiolaging.2013.04.021  0.479
2013 LaPointe NE, Morfini G, Brady ST, Feinstein SC, Wilson L, Jordan MA. Effects of eribulin, vincristine, paclitaxel and ixabepilone on fast axonal transport and kinesin-1 driven microtubule gliding: implications for chemotherapy-induced peripheral neuropathy. Neurotoxicology. 37: 231-9. PMID 23711742 DOI: 10.1016/J.Neuro.2013.05.008  0.464
2013 Kanaan NM, Pigino GF, Brady ST, Lazarov O, Binder LI, Morfini GA. Axonal degeneration in Alzheimer's disease: when signaling abnormalities meet the axonal transport system. Experimental Neurology. 246: 44-53. PMID 22721767 DOI: 10.1016/J.Expneurol.2012.06.003  0.722
2013 Hennigan RF, Moon CA, Parysek LM, Monk KR, Morfini G, Berth S, Brady S, Ratner N. The NF2 tumor suppressor regulates microtubule-based vesicle trafficking via a novel Rac, MLK and p38(SAPK) pathway. Oncogene. 32: 1135-43. PMID 22525268 DOI: 10.1038/Onc.2012.135  0.377
2012 Chu Y, Morfini GA, Langhamer LB, He Y, Brady ST, Kordower JH. Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease. Brain : a Journal of Neurology. 135: 2058-73. PMID 22719003 DOI: 10.1093/Brain/Aws133  0.438
2012 Brunholz S, Sisodia S, Lorenzo A, Deyts C, Kins S, Morfini G. Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells. Experimental Brain Research. 217: 353-64. PMID 21960299 DOI: 10.1007/S00221-011-2870-1  0.521
2012 Kanaan NM, Morfini G, Pigino G, LaPointe NE, Andreadis A, Song Y, Leitman E, Binder LI, Brady ST. Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport. Neurobiology of Aging. 33: 826.e15-30. PMID 21794954 DOI: 10.1016/J.Neurobiolaging.2011.06.006  0.727
2011 Patterson KR, Ward SM, Combs B, Voss K, Kanaan NM, Morfini G, Brady ST, Gamblin TC, Binder LI. Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport. Biochemistry. 50: 10300-10. PMID 22039833 DOI: 10.1021/Bi2009147  0.712
2011 Kanaan NM, Morfini GA, LaPointe NE, Pigino GF, Patterson KR, Song Y, Andreadis A, Fu Y, Brady ST, Binder LI. Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 9858-68. PMID 21734277 DOI: 10.1523/Jneurosci.0560-11.2011  0.76
2011 Smith JA, LaPointe N, Morfini G, Brady S, Feinstein S, Wilson L, Jordan MA. Abstract C213: Eribulin, vincristine, ixabepilone, and paclitaxel inhibit neuronal cell function by varied mechanisms and to varying degrees. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-C213  0.484
2010 Brady S, Morfini G. A perspective on neuronal cell death signaling and neurodegeneration Molecular Neurobiology. 42: 25-31. PMID 20480262 DOI: 10.1007/S12035-010-8128-2  0.388
2010 Kins S, Hunzelmann S, Szodorai A, Kuan Y, Engel U, Müller U, Beyreuther K, Brady S, Morfini G. Assembly of APP anterograde transport vesicles Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.316  0.362
2009 Szodorai A, Kuan YH, Hunzelmann S, Engel U, Sakane A, Sasaki T, Takai Y, Kirsch J, Müller U, Beyreuther K, Brady S, Morfini G, Kins S. APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 14534-44. PMID 19923287 DOI: 10.1523/Jneurosci.1546-09.2009  0.432
2009 Morfini GA, Burns M, Binder LI, Kanaan NM, LaPointe N, Bosco DA, Brown RH, Brown H, Tiwari A, Hayward L, Edgar J, Nave KA, Garberrn J, Atagi Y, Song Y, et al. Axonal transport defects in neurodegenerative diseases. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12776-86. PMID 19828789 DOI: 10.1523/Jneurosci.3463-09.2009  0.702
2009 Morfini GA, You YM, Pollema SL, Kaminska A, Liu K, Yoshioka K, Björkblom B, Coffey ET, Bagnato C, Han D, Huang CF, Banker G, Pigino G, Brady ST. Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin. Nature Neuroscience. 12: 864-71. PMID 19525941 DOI: 10.1038/Nn.2346  0.526
2009 LaPointe NE, Morfini G, Pigino G, Gaisina IN, Kozikowski AP, Binder LI, Brady ST. The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity. Journal of Neuroscience Research. 87: 440-51. PMID 18798283 DOI: 10.1002/Jnr.21850  0.539
2008 DeBoer SR, You Y, Szodorai A, Kaminska A, Pigino G, Nwabuisi E, Wang B, Estrada-Hernandez T, Kins S, Brady ST, Morfini G. Conventional kinesin holoenzymes are composed of heavy and light chain homodimers. Biochemistry. 47: 4535-43. PMID 18361505 DOI: 10.1021/Bi702445J  0.442
2008 Solowska JM, Morfini G, Falnikar A, Himes BT, Brady ST, Huang D, Baas PW. Quantitative and functional analyses of spastin in the nervous system: implications for hereditary spastic paraplegia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 2147-57. PMID 18305248 DOI: 10.1523/Jneurosci.3159-07.2008  0.421
2007 Morfini G, Pigino G, Brady ST. Approaches to kinesin-1 phosphorylation. Methods in Molecular Biology (Clifton, N.J.). 392: 51-69. PMID 17951710 DOI: 10.1007/978-1-59745-490-2_4  0.357
2007 Lazarov O, Morfini GA, Pigino G, Gadadhar A, Chen X, Robinson J, Ho H, Brady ST, Sisodia SS. Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 7011-20. PMID 17596450 DOI: 10.1523/Jneurosci.4272-06.2007  0.47
2007 Morfini G, Pigino G, Opalach K, Serulle Y, Moreira JE, Sugimori M, Llinás RR, Brady ST. 1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C. Proceedings of the National Academy of Sciences of the United States of America. 104: 2442-7. PMID 17287338 DOI: 10.1073/Pnas.0611231104  0.483
2007 Morfini G, Pigino G, Mizuno N, Kikkawa M, Brady ST. Tau binding to microtubules does not directly affect microtubule-based vesicle motility. Journal of Neuroscience Research. 85: 2620-30. PMID 17265463 DOI: 10.1002/Jnr.21154  0.535
2006 Morfini G, Pigino G, Szebenyi G, You Y, Pollema S, Brady ST. JNK mediates pathogenic effects of polyglutamine-expanded androgen receptor on fast axonal transport. Nature Neuroscience. 9: 907-16. PMID 16751763 DOI: 10.1038/Nn1717  0.512
2005 Lazarov O, Morfini GA, Lee EB, Farah MH, Szodorai A, DeBoer SR, Koliatsos VE, Kins S, Lee VM, Wong PC, Price DL, Brady ST, Sisodia SS. Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2386-95. PMID 15745965 DOI: 10.1523/Jneurosci.3089-04.2005  0.404
2005 Morfini G, Pigino G, Brady ST. Polyglutamine expansion diseases: failing to deliver. Trends in Molecular Medicine. 11: 64-70. PMID 15694868 DOI: 10.1016/J.Molmed.2004.12.002  0.501
2004 Morfini G, Szebenyi G, Brown H, Pant HC, Pigino G, DeBoer S, Beffert U, Brady ST. A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons. The Embo Journal. 23: 2235-45. PMID 15152189 DOI: 10.1038/Sj.Emboj.7600237  0.592
2004 Beffert U, Weeber EJ, Morfini G, Ko J, Brady ST, Tsai LH, Sweatt JD, Herz J. Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 1897-906. PMID 14985430 DOI: 10.1523/Jneurosci.4084-03.2004  0.372
2003 Szebenyi G, Morfini GA, Babcock A, Gould M, Selkoe K, Stenoien DL, Young M, Faber PW, MacDonald ME, McPhaul MJ, Brady ST. Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport. Neuron. 40: 41-52. PMID 14527432 DOI: 10.1016/S0896-6273(03)00569-5  0.503
2003 Pigino G, Morfini G, Pelsman A, Mattson MP, Brady ST, Busciglio J. Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4499-508. PMID 12805290 DOI: 10.1523/Jneurosci.23-11-04499.2003  0.516
2002 Morfini G, Pigino G, Beffert U, Busciglio J, Brady ST. Fast axonal transport misregulation and Alzheimer's disease. Neuromolecular Medicine. 2: 89-99. PMID 12428805 DOI: 10.1385/Nmm:2:2:089  0.539
2002 Szebenyi G, Morfini G, Brady ST. Pictures in cell biology. GSK-3 and regulation of kinesin function. Trends in Cell Biology. 12: 245. PMID 12062174 DOI: 10.1016/S0962-8924(02)02283-3  0.315
2002 Morfini G, Szebenyi G, Elluru R, Ratner N, Brady ST. Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility. The Embo Journal. 21: 281-93. PMID 11823421 DOI: 10.1093/Emboj/21.3.281  0.441
1998 Paglini G, Pigino G, Kunda P, Morfini G, Maccioni R, Quiroga S, Ferreira A, Cáceres A. Evidence for the participation of the neuron-specific CDK5 activator p35 during laminin-enhanced axonal growth Journal of Neuroscience. 18: 9858-9869. PMID 9822744 DOI: 10.1523/Jneurosci.18-23-09858.1998  0.418
1995 Morfini G, DiTella MC, Feiguin F, Carri N, Cáceres A. Neurotrophin-3 enhances neurite outgrowth in cultured hippocampal pyramidal neurons. Journal of Neuroscience Research. 39: 219-32. PMID 7837290 DOI: 10.1002/JNR.490390212  0.361
1995 DiTella M, Feiguin F, Morfini G, Cáceres A. Microfilament-associated growth cone component depends upon Tau for its intracellular localization. Cell Motility and the Cytoskeleton. 29: 117-30. PMID 7820862 DOI: 10.1002/CM.970290204  0.353
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