☰

Oksana Berezovska - Publications

Affiliations: 
Neuroscience Massachusetts General Hospital, Boston, MA 
Tree Info Grants Similar researchers Related pubs Distance to... Nearest Nobel PubMed Report error

50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Zoltowska KM, Das U, Lismont S, Enzlein T, Maesako M, Houser MCQ, Franco ML, Özcan B, Gomes Moreira D, Karachentsev D, Becker A, Hopf C, Vilar M, Berezovska O, Mobley W, et al. Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling. Elife. 12. PMID 39027984 DOI: 10.7554/eLife.90690  0.809
2024 Perrin F, Sinha P, Mitchell SPC, Sadek M, Maesako M, Berezovska O. Identification of PS1/gamma-secretase and glutamate transporter GLT-1 interaction sites. The Journal of Biological Chemistry. 107172. PMID 38499151 DOI: 10.1016/j.jbc.2024.107172  0.543
2024 Hou SS, Ikegawa Y, Kwon Y, Houser MCQ, Lundin B, Bacskai BJ, Berezovska O, Maesako M. Recording γ-secretase activity in living mouse brains. Biorxiv : the Preprint Server For Biology. PMID 38352497 DOI: 10.1101/2024.01.31.578105  0.471
2023 Perrin F, Anderson LC, Mitchell SPC, Sinha P, Turchyna Y, Maesako M, Houser MCQ, Zhang C, Wagner SL, Tanzi RE, Berezovska O. PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer's disease. Research Square. PMID 37986905 DOI: 10.21203/rs.3.rs-3495211/v1  0.515
2023 Perrin F, Sinha P, Mitchell S, Maesako M, Berezovska O. Identification of PS1/gamma-secretase and glutamate transporter GLT-1 interaction sites. Biorxiv : the Preprint Server For Biology. PMID 37398024 DOI: 10.1101/2023.05.30.542955  0.543
2023 Houser MCQ, Mitchell SPC, Sinha P, Lundin B, Berezovska O, Maesako M. Endosome and Lysosome Membrane Properties Functionally Link to γ-Secretase in Live/Intact Cells. Sensors (Basel, Switzerland). 23. PMID 36904854 DOI: 10.3390/s23052651  0.601
2022 Konstantinidis E, Molisak A, Perrin F, Streubel-Gallasch L, Fayad S, Kim DY, Petri K, Aryee MJ, Aguilar X, György B, Giedraitis V, Joung JK, Pattanayak V, Essand M, Erlandsson A, ... Berezovska O, et al. CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease M146L mutation. Molecular Therapy. Nucleic Acids. 28: 450-461. PMID 35505961 DOI: 10.1016/j.omtn.2022.03.022  0.583
2021 Maesako M, Houser MCQ, Turchyna Y, Wolfe MS, Berezovska O. Presenilin/γ-Secretase Activity Is Located in Acidic Compartments of Live Neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 42: 145-154. PMID 34810230 DOI: 10.1523/JNEUROSCI.1698-21.2021  0.788
2020 Houser MC, Hou SS, Perrin F, Turchyna Y, Bacskai BJ, Berezovska O, Maesako M. A Novel NIR-FRET Biosensor for Reporting PS/γ-Secretase Activity in Live Cells. Sensors (Basel, Switzerland). 20. PMID 33105735 DOI: 10.3390/s20215980  0.362
2020 Maesako M, Sekula NM, Aristarkhova A, Feschenko P, Anderson LC, Berezovska O. Visualization of PS/γ-Secretase Activity in Living Cells. Iscience. 23: 101139. PMID 32438286 DOI: 10.1016/J.Isci.2020.101139  0.329
2019 Keller LJ, Sekula NM, Svirsky S, Maesako M, Zoltowska KM, Berezovska O. Presenilin 1 increases association with synaptotagmin 1 during normal aging. Neurobiology of Aging. PMID 31864759 DOI: 10.1016/j.neurobiolaging.2019.10.006  0.318
2018 Zoltowska KM, Maesako M, Meier J, Berezovska O. Novel interaction between Alzheimer's disease-related protein presenilin 1 and glutamate transporter 1. Scientific Reports. 8: 8718. PMID 29880815 DOI: 10.1038/s41598-018-26888-2  0.589
2017 Raven F, Ward JF, Zoltowska KM, Wan Y, Bylykbashi E, Miller SJ, Shen X, Choi SH, Rynearson KD, Berezovska O, Wagner SL, Tanzi RE, Zhang C. Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1. Ebiomedicine. PMID 28919280 DOI: 10.1016/J.Ebiom.2017.08.028  0.651
2017 Zoltowska KM, Maesako M, Lushnikova I, Takeda S, Keller LJ, Skibo G, Hyman BT, Berezovska O. Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production. Molecular Neurodegeneration. 12: 15. PMID 28193235 DOI: 10.1186/S13024-017-0159-Y  0.508
2017 Maesako M, Horlacher J, Zoltowska KM, Kastanenka KV, Kara E, Svirsky S, Keller LJ, Li X, Hyman BT, Bacskai BJ, Berezovska O. Pathogenic PS1 phosphorylation at Ser367. Elife. 6. PMID 28132667 DOI: 10.7554/Elife.19720  0.347
2016 Kuzuya A, Zoltowska KM, Post KL, Arimon M, Li X, Svirsky S, Maesako M, Muzikansky A, Gautam V, Kovacs D, Hyman BT, Berezovska O. Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta. Bmc Biology. 14: 25. PMID 27036734 DOI: 10.1186/S12915-016-0248-3  0.582
2015 Gautam V, D'Avanzo C, Berezovska O, Tanzi RE, Kovacs DM. Synaptotagmins interact with APP and promote Aβ generation. Molecular Neurodegeneration. 10: 31. PMID 26202512 DOI: 10.1186/S13024-015-0028-5  0.538
2015 Arimon M, Takeda S, Post KL, Svirsky S, Hyman BT, Berezovska O. Oxidative stress and lipid peroxidation are upstream of amyloid pathology. Neurobiology of Disease. PMID 26102023 DOI: 10.1016/J.Nbd.2015.06.013  0.427
2014 Winslow AR, Moussaud S, Zhu L, Post KL, Post KL, Dickson DW, Berezovska O, McLean PJ. Convergence of pathology in dementia with Lewy bodies and Alzheimer's disease: a role for the novel interaction of alpha-synuclein and presenilin 1 in disease. Brain : a Journal of Neurology. 137: 1958-70. PMID 24860142 DOI: 10.1093/Brain/Awu119  0.313
2013 Wahlster L, Arimon M, Nasser-Ghodsi N, Post KL, Serrano-Pozo A, Uemura K, Berezovska O. Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer's disease. Acta Neuropathologica. 125: 187-99. PMID 23138650 DOI: 10.1007/S00401-012-1065-6  0.611
2013 Li X, Uemura K, Hashimoto T, Nasser-Ghodsi N, Arimon M, Lill CM, Palazzolo I, Krainc D, Hyman BT, Berezovska O. Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions. Neurobiology of Disease. 50: 127-34. PMID 23064434 DOI: 10.1016/J.Nbd.2012.10.002  0.648
2012 Wu HY, Hudry E, Hashimoto T, Uemura K, Fan ZY, Berezovska O, Grosskreutz CL, Bacskai BJ, Hyman BT. Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-β revealed by a novel fluorescence resonance energy transfer assay. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 5298-309. PMID 22496575 DOI: 10.1523/Jneurosci.0227-12.2012  0.463
2012 Guix FX, Wahle T, Vennekens K, Snellinx A, Chávez-Gutiérrez L, Ill-Raga G, Ramos-Fernandez E, Guardia-Laguarta C, Lleó A, Arimon M, Berezovska O, Muñoz FJ, Dotti CG, De Strooper B. Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease. Embo Molecular Medicine. 4: 660-73. PMID 22488900 DOI: 10.1002/Emmm.201200243  0.634
2011 Ohki Y, Higo T, Uemura K, Shimada N, Osawa S, Berezovska O, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T. Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1. The Embo Journal. 30: 4815-24. PMID 22002539 DOI: 10.1038/Emboj.2011.372  0.41
2011 Asada-Utsugi M, Uemura K, Noda Y, Kuzuya A, Maesako M, Ando K, Kubota M, Watanabe K, Takahashi M, Kihara T, Shimohama S, Takahashi R, Berezovska O, Kinoshita A. N-cadherin enhances APP dimerization at the extracellular domain and modulates Aβ production. Journal of Neurochemistry. 119: 354-63. PMID 21699541 DOI: 10.1016/J.Neures.2011.07.1720  0.387
2011 Viswanathan J, Haapasalo A, Böttcher C, Miettinen R, Kurkinen KM, Lu A, Thomas A, Maynard CJ, Romano D, Hyman BT, Berezovska O, Bertram L, Soininen H, Dantuma NP, Tanzi RE, et al. Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation. Traffic (Copenhagen, Denmark). 12: 330-48. PMID 21143716 DOI: 10.1111/J.1600-0854.2010.01149.X  0.567
2010 Uemura K, Farner KC, Hashimoto T, Nasser-Ghodsi N, Wolfe MS, Koo EH, Hyman BT, Berezovska O. Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site. Nature Communications. 1: 130. PMID 21119643 DOI: 10.1038/Ncomms1129  0.316
2009 Uemura K, Lill CM, Li X, Peters JA, Ivanov A, Fan Z, DeStrooper B, Bacskai BJ, Hyman BT, Berezovska O. Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio. Plos One. 4: e7893. PMID 19924286 DOI: 10.1371/Journal.Pone.0007893  0.498
2009 Huttunen HJ, Peach C, Bhattacharyya R, Barren C, Pettingell W, Hutter-Paier B, Windisch M, Berezovska O, Kovacs DM. Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 3819-28. PMID 19625658 DOI: 10.1096/fj.09-134999  0.632
2009 Guardia-Laguarta C, Coma M, Pera M, Clarimón J, Sereno L, Agulló JM, Molina-Porcel L, Gallardo E, Deng A, Berezovska O, Hyman BT, Blesa R, Gómez-Isla T, Lleó A. Mild cholesterol depletion reduces amyloid-beta production by impairing APP trafficking to the cell surface. Journal of Neurochemistry. 110: 220-30. PMID 19457132 DOI: 10.1111/J.1471-4159.2009.06126.X  0.426
2009 Serneels L, Van Biervliet J, Craessaerts K, Dejaegere T, Horré K, Van Houtvin T, Esselmann H, Paul S, Schäfer MK, Berezovska O, Hyman BT, Sprangers B, Sciot R, Moons L, Jucker M, et al. gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease. Science (New York, N.Y.). 324: 639-42. PMID 19299585 DOI: 10.1126/Science.1171176  0.35
2009 Herl L, Thomas AV, Lill CM, Banks M, Deng A, Jones PB, Spoelgen R, Hyman BT, Berezovska O. Mutations in amyloid precursor protein affect its interactions with presenilin/gamma-secretase. Molecular and Cellular Neurosciences. 41: 166-74. PMID 19281847 DOI: 10.1016/J.Mcn.2009.02.008  0.501
2009 Uemura K, Lill CM, Banks M, Asada M, Aoyagi N, Ando K, Kubota M, Kihara T, Nishimoto T, Sugimoto H, Takahashi R, Hyman BT, Shimohama S, Berezovska O, Kinoshita A. N-cadherin-based adhesion enhances Abeta release and decreases Abeta42/40 ratio. Journal of Neurochemistry. 108: 350-60. PMID 19046403 DOI: 10.1111/J.1471-4159.2008.05760.X  0.397
2008 Thomas AV, Berezovska O, Hyman BT, von Arnim CA. Visualizing interaction of proteins relevant to Alzheimer's disease in intact cells. Methods (San Diego, Calif.). 44: 299-303. PMID 18374273 DOI: 10.1016/J.Ymeth.2007.02.003  0.564
2008 Jones PB, Rozkalne A, Meyer-Luehmann M, Spires-Jones TL, Makarova A, Kumar AT, Berezovska O, Bacskai BB, Hyman BT. Two postprocessing techniques for the elimination of background autofluorescence for fluorescence lifetime imaging microscopy. Journal of Biomedical Optics. 13: 014008. PMID 18315366 DOI: 10.1117/1.2837169  0.345
2006 Nyborg AC, Herl L, Berezovska O, Thomas AV, Ladd TB, Jansen K, Hyman BT, Golde TE. Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells. Molecular Neurodegeneration. 1: 16. PMID 17105660 DOI: 10.1186/1750-1326-1-16  0.317
2006 Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas MZ, Wagner SL, Berezovska O, Hyman BT, Tesco G, Bertram L, Tanzi RE. Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. The Journal of Biological Chemistry. 281: 32240-53. PMID 16945923 DOI: 10.1074/Jbc.M603106200  0.556
2006 Thomas AV, Herl L, Spoelgen R, Hiltunen M, Jones PB, Tanzi RE, Hyman BT, Berezovska O. Interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader. The Journal of Biological Chemistry. 281: 26400-7. PMID 16815845 DOI: 10.1074/Jbc.M601085200  0.507
2005 Tesco G, Ginestroni A, Hiltunen M, Kim M, Dolios G, Hyman BT, Wang R, Berezovska O, Tanzi RE. APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation. Journal of Neurochemistry. 95: 446-56. PMID 16086682 DOI: 10.1111/J.1471-4159.2005.03381.X  0.548
2005 Lleó A, Waldron E, von Arnim CA, Herl L, Tangredi MM, Peltan ID, Strickland DK, Koo EH, Hyman BT, Pietrzik CU, Berezovska O. Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase. The Journal of Biological Chemistry. 280: 27303-9. PMID 15917251 DOI: 10.1074/Jbc.M413969200  0.436
2005 Berezovska O, Lleo A, Herl LD, Frosch MP, Stern EA, Bacskai BJ, Hyman BT. Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 3009-17. PMID 15772361 DOI: 10.1523/Jneurosci.0364-05.2005  0.429
2004 Lleó A, Berezovska O, Herl L, Raju S, Deng A, Bacskai BJ, Frosch MP, Irizarry M, Hyman BT. Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation. Nature Medicine. 10: 1065-6. PMID 15448688 DOI: 10.1038/Nm1112  0.349
2004 Irizarry MC, Deng A, Lleo A, Berezovska O, Von Arnim CA, Martin-Rehrmann M, Manelli A, LaDu MJ, Hyman BT, Rebeck GW. Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein. Journal of Neurochemistry. 90: 1132-43. PMID 15312168 DOI: 10.1111/J.1471-4159.2004.02581.X  0.52
2004 Lleó A, Berezovska O, Growdon JH, Hyman BT. Clinical, pathological, and biochemical spectrum of Alzheimer disease associated with PS-1 mutations. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. 12: 146-56. PMID 15010344 DOI: 10.1097/00019442-200403000-00006  0.449
2003 Das C, Berezovska O, Diehl TS, Genet C, Buldyrev I, Tsai JY, Hyman BT, Wolfe MS. Designed helical peptides inhibit an intramembrane protease. Journal of the American Chemical Society. 125: 11794-5. PMID 14505382 DOI: 10.1021/Ja037131V  0.384
2003 Lleó A, Berezovska O, Ramdya P, Fukumoto H, Raju S, Shah T, Hyman BT. Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression. The Journal of Biological Chemistry. 278: 47370-5. PMID 12960155 DOI: 10.1074/Jbc.M308480200  0.355
2003 Berezovska O, Bacskai BJ, Hyman BT. Monitoring proteins in intact cells. Science of Aging Knowledge Environment : Sage Ke. 2003: PE14. PMID 12844526 DOI: 10.1126/Sageke.2003.23.Pe14  0.373
2003 Berezovska O, Ramdya P, Skoch J, Wolfe MS, Bacskai BJ, Hyman BT. Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4560-6. PMID 12805296  0.427
2003 Micchelli CA, Esler WP, Kimberly WT, Jack C, Berezovska O, Kornilova A, Hyman BT, Perrimon N, Wolfe MS. Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 79-81. PMID 12424225 DOI: 10.1096/Fj.02-0394Fje  0.307
2002 Kinoshita A, Whelan CM, Berezovska O, Hyman BT. The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells. The Journal of Biological Chemistry. 277: 28530-6. PMID 12032152 DOI: 10.1074/Jbc.M203372200  0.464
Show low-probability matches.