Tadafumi Hashimoto - Publications

2012-2021 The University of Tokyo, Bunkyō-ku, Tōkyō-to, Japan 
 2021- National Center of Neurology and Psychiatry, Tokyo, Kodaira-shi, Tōkyō-to, Japan 
Alzheimer's disease, Neurodegenerative disorders

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Year Citation  Score
2024 Murakami R, Watanabe H, Hashimoto H, Kashiwagi-Hakozaki M, Hashimoto T, Karch CM, Iwatsubo T, Okano H. Inhibitory roles of Christchurch astrocytes in curbing tau propagation using human pluripotent stem cell-derived models. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 38649269 DOI: 10.1523/JNEUROSCI.1709-23.2024  0.483
2023 Watanabe H, Murakami R, Tsumagari K, Morimoto S, Hashimoto T, Imaizumi K, Sonn I, Yamada K, Saito Y, Murayama S, Iwatsubo T, Okano H. Astrocytic APOE4 genotype-mediated negative impacts on synaptic architecture in human pluripotent stem cell model. Stem Cell Reports. 18: 1854-1869. PMID 37657448 DOI: 10.1016/j.stemcr.2023.08.002  0.558
2022 Kishino Y, Matsukawa K, Matsumoto T, Miyazaki R, Wakabayashi T, Nonaka T, Kametani F, Hasegawa M, Hashimoto T, Iwatsubo T. Casein kinase 1δ/ε phosphorylates fused in sarcoma (FUS) and ameliorates FUS-mediated neurodegeneration. The Journal of Biological Chemistry. 102191. PMID 35753345 DOI: 10.1016/j.jbc.2022.102191  0.388
2022 Kaneshiro N, Komai M, Imaoka R, Ikeda A, Kamikubo Y, Saito T, Saido TC, Tomita T, Hashimoto T, Iwatsubo T, Sakurai T, Uehara T, Takasugi N. Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer's disease. Iscience. 25: 103869. PMID 35243232 DOI: 10.1016/j.isci.2022.103869  0.644
2022 Ishida K, Yamada K, Nishiyama R, Hashimoto T, Nishida I, Abe Y, Yasui M, Iwatsubo T. Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration. The Journal of Experimental Medicine. 219. PMID 35212707 DOI: 10.1084/jem.20211275  0.542
2021 An H, Litscher G, Watanabe N, Wei W, Hashimoto T, Iwatsubo T, Buchman VL, Shelkovnikova TA. ALS-linked cytoplasmic FUS assemblies are compositionally different from physiological stress granules and sequester hnRNPA3, a novel modifier of FUS toxicity. Neurobiology of Disease. 162: 105585. PMID 34915152 DOI: 10.1016/j.nbd.2021.105585  0.411
2021 Matsukawa K, Kukharsky MS, Park SK, Park S, Watanabe N, Iwatsubo T, Hashimoto T, Liebman SW, Shelkovnikova TA. Long non-coding RNA NEAT1_1 ameliorates TDP-43 toxicity in in vivo models of TDP-43 proteinopathy. Rna Biology. 1-9. PMID 33427561 DOI: 10.1080/15476286.2020.1860580  0.497
2020 Hashimoto T, Fujii D, Naka Y, Kashiwagi-Hakozaki M, Matsuo Y, Matsuura Y, Wakabayashi T, Iwatsubo T. Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques. Acta Neuropathologica Communications. 8: 212. PMID 33287899 DOI: 10.1186/s40478-020-01075-5  0.64
2020 Abe Y, Ikegawa N, Yoshida K, Muramatsu K, Hattori S, Kawai K, Murakami M, Tanaka T, Goda W, Goto M, Yamamoto T, Hashimoto T, Yamada K, Shibata T, Misawa H, et al. Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model. Acta Neuropathologica Communications. 8: 67. PMID 32398151 DOI: 10.1186/S40478-020-00936-3  0.606
2019 Munezane H, Oizumi H, Wakabayashi T, Nishio S, Hirasawa T, Sato T, Harada A, Yoshida T, Eguchi T, Yamanashi Y, Hashimoto T, Iwatsubo T. Roles of Collagen XXV and Its Putative Receptors PTPσ/δ in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder. Cell Reports. 29: 4362-4376.e6. PMID 31875546 DOI: 10.1016/J.Celrep.2019.11.112  0.427
2019 Park S, Park SK, Watanabe N, Hashimoto T, Iwatsubo T, Shelkovnikova TA, Liebman SW. Calcium-responsive transactivator (CREST) toxicity is rescued by loss of PBP1/ATXN2 function in a novel yeast proteinopathy model and in transgenic flies. Plos Genetics. 15: e1008308. PMID 31390360 DOI: 10.1371/Journal.Pgen.1008308  0.544
2019 Eto M, Hashimoto T, Shimizu T, Iwatsubo T. Characterization of the unique In Vitro effects of unsaturated fatty acids on the formation of amyloid β fibrils. Plos One. 14: e0219465. PMID 31291354 DOI: 10.1371/Journal.Pone.0219465  0.6
2019 Wakabayashi T, Yamaguchi K, Matsui K, Sano T, Kubota T, Hashimoto T, Mano A, Yamada K, Matsuo Y, Kubota N, Kadowaki T, Iwatsubo T. Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer's disease. Molecular Neurodegeneration. 14: 15. PMID 30975165 DOI: 10.1186/S13024-019-0315-7  0.579
2019 Bannai T, Mano T, Chen X, Ohtomo G, Ohtomo R, Tsuchida T, Koshi-Mano K, Hashimoto T, Okazawa H, Iwatsubo T, Tsuji S, Toda T, Iwata A. Chronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight. Scientific Reports. 9: 2827. PMID 30808940 DOI: 10.1038/S41598-019-39494-7  0.645
2018 Mann DMA, Davidson YS, Robinson AC, Allen N, Hashimoto T, Richardson A, Jones M, Snowden JS, Pendleton N, Potier MC, Laquerrière A, Prasher V, Iwatsubo T, Strydom A. Patterns and severity of vascular amyloid in Alzheimer's disease associated with duplications and missense mutations in APP gene, Down syndrome and sporadic Alzheimer's disease. Acta Neuropathologica. PMID 29770843 DOI: 10.1007/S00401-018-1866-3  0.623
2018 Hori Y, Hashimoto T, Nomoto H, Hyman BT, Iwatsubo T. Role of apolipoprotein E in β-amyloidogenesis: Isoform-specific effects on protofibril to fibril conversion of Aβ and brain Aβ deposition . The Journal of Biological Chemistry. 293: 7267. PMID 29752420 DOI: 10.1074/jbc.AAC118.003576  0.636
2018 Matsumoto T, Matsukawa K, Watanabe N, Kishino Y, Kunugi H, Ihara R, Wakabayashi T, Hashimoto T, Iwatsubo T. Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration. Human Molecular Genetics. PMID 29425337 DOI: 10.1093/Hmg/Ddy046  0.498
2018 Bannai T, Iwata A, Mano T, Ohtomo R, Ohtomo G, Hashimoto T, Iwatsubo T, Toda T. P2-070: Chronic Cerebral Hypoperfusion Increases Amyloid Plaques By Accelerating Amyloid Beta Aggregation In App/Ps1 Transgenic Mice Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.755  0.605
2017 Mano T, Nagata K, Nonaka T, Tarutani A, Imamura T, Hashimoto T, Bannai T, Koshi-Mano K, Tsuchida T, Ohtomo R, Takahashi-Fujigasaki J, Yamashita S, Ohyagi Y, Yamasaki R, Tsuji S, et al. Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 29042514 DOI: 10.1073/Pnas.1707151114  0.655
2017 Arbel-Ornath M, Hudry E, Boivin JR, Hashimoto T, Takeda S, Kuchibhotla KV, Hou S, Lattarulo CR, Belcher AM, Shakerdge N, Trujillo PB, Muzikansky A, Betensky RA, Hyman BT, Bacskai BJ. Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain. Molecular Neurodegeneration. 12: 27. PMID 28327181 DOI: 10.1186/S13024-017-0169-9  0.656
2016 Matsukawa K, Hashimoto T, Matsumoto T, Ihara R, Chihara T, Miura M, Wakabayashi T, Iwatsubo T. Familial ALS-linked Mutations in Profilin 1 Exacerbate TDP-43-induced Degeneration in the Retina of Drosophila Melanogaster through an Increase in the Cytoplasmic Localization of TDP-43. The Journal of Biological Chemistry. PMID 27634045 DOI: 10.1074/Jbc.M116.729152  0.484
2016 Iwata A, Mano T, Ohtomo R, Nagata K, Saido TC, Yamashita S, Ushijima T, Hashimoto T, Iwatsubo T, Tamaoka A, Tsuji S. Neuron-Specific Methylome Analysis Reveals New Pathomechanism In Alzheimer’S Disease Brains Alzheimers & Dementia. 12: 240. DOI: 10.1016/J.Jalz.2016.06.427  0.517
2016 Mano T, Ohtomo R, Nagata K, Murayama S, Saido TC, Yamashita S, Ushijima T, Hashimoto T, Tamaoka A, Iwatsubo T, Tsuji S, Iwata A. P2-073: Epigenetic Regulation of BRCA1 in Alzheimer’S Disease: Evaluation of Postmortem Brain and Model Mice Reveals Importance of Aggregated TAU Alzheimer's & Dementia. 12: P635-P636. DOI: 10.1016/J.Jalz.2016.06.1278  0.572
2015 Yamamoto K, Tanei Z, Hashimoto T, Wakabayashi T, Okuno H, Naka Y, Yizhar O, Fenno LE, Fukayama M, Bito H, Cirrito JR, Holtzman DM, Deisseroth K, Iwatsubo T. Chronic optogenetic activation augments aβ pathology in a mouse model of Alzheimer disease. Cell Reports. 11: 859-65. PMID 25937280 DOI: 10.1016/J.Celrep.2015.04.017  0.61
2015 Hori Y, Hashimoto T, Nomoto H, Hyman BT, Iwatsubo T. Role of Apolipoprotein E in β-Amyloidogenesis: ISOFORM-SPECIFIC EFFECTS ON PROTOFIBRIL TO FIBRIL CONVERSION OF Aβ IN VITRO AND BRAIN Aβ DEPOSITION IN VIVO. The Journal of Biological Chemistry. 290: 15163-74. PMID 25918154 DOI: 10.1074/Jbc.M114.622209  0.718
2015 Kukharsky MS, Quintiero A, Matsumoto T, Matsukawa K, An H, Hashimoto T, Iwatsubo T, Buchman VL, Shelkovnikova TA. Calcium-responsive transactivator (CREST) protein shares a set of structural and functional traits with other proteins associated with amyotrophic lateral sclerosis. Molecular Neurodegeneration. 10: 20. PMID 25888396 DOI: 10.1186/S13024-015-0014-Y  0.498
2014 Farrar CT, William CM, Hudry E, Hashimoto T, Hyman BT. RNA aptamer probes as optical imaging agents for the detection of amyloid plaques. Plos One. 9: e89901. PMID 24587111 DOI: 10.1371/Journal.Pone.0089901  0.468
2014 Tanaka T, Wakabayashi T, Oizumi H, Nishio S, Sato T, Harada A, Fujii D, Matsuo Y, Hashimoto T, Iwatsubo T. CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 1370-9. PMID 24453327 DOI: 10.1523/Jneurosci.2440-13.2014  0.478
2013 Iwatsubo T, Hashimoto T, Wakabayashi T, Tomita T, Morohashi Y. [Alzheimer disease: experimental approaches to genetic and environmental risk factors]. Rinshō Shinkeigaku = Clinical Neurology. 53: 956. PMID 24291845 DOI: DN/JST.JSTAGE/clinicalneurol/53.956  0.534
2013 Hudry E, Dashkoff J, Roe AD, Takeda S, Koffie RM, Hashimoto T, Scheel M, Spires-Jones T, Arbel-Ornath M, Betensky R, Davidson BL, Hyman BT. Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain. Science Translational Medicine. 5: 212ra161. PMID 24259049 DOI: 10.1126/Scitranslmed.3007000  0.737
2013 Ihara R, Matsukawa K, Nagata Y, Kunugi H, Tsuji S, Chihara T, Kuranaga E, Miura M, Wakabayashi T, Hashimoto T, Iwatsubo T. RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy. Human Molecular Genetics. 22: 4474-84. PMID 23804749 DOI: 10.1093/Hmg/Ddt296  0.47
2013 Cho H, Hashimoto T, Wong E, Hori Y, Wood LB, Zhao L, Haigis KM, Hyman BT, Irimia D. Microfluidic chemotaxis platform for differentiating the roles of soluble and bound amyloid-β on microglial accumulation. Scientific Reports. 3: 1823. PMID 23665843 DOI: 10.1038/Srep01823  0.587
2013 Takeda S, Hashimoto T, Roe AD, Hori Y, Spires-Jones TL, Hyman BT. Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 3239-48. PMID 23640054 DOI: 10.1096/Fj.13-229666  0.732
2013 Li X, Uemura K, Hashimoto T, Nasser-Ghodsi N, Arimon M, Lill CM, Palazzolo I, Krainc D, Hyman BT, Berezovska O. Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions. Neurobiology of Disease. 50: 127-34. PMID 23064434 DOI: 10.1016/J.Nbd.2012.10.002  0.586
2013 Hashimoto T, Kunugi H, Matsukawa K, Uchigami H, Ihara R, Chihara T, Miura M, Wakabayashi T, Iwatsubo T. Two distinct pathways leading to retinal degeneration in transgenic Drosophila melanogaster overexpressing human FUS Alzheimers & Dementia. 9: 170. DOI: 10.1016/J.Jalz.2013.05.269  0.59
2013 Hudry E, Arbel-Ornath M, Hashimoto T, Boivin J, Lattarulo C, Bacskai B, Hyman B. O1-01-03: Oligomeric soluble beta-amyloid species induce calcium dyshomeostasis in the healthy living mouse brain Alzheimer's & Dementia. 9: P126-P126. DOI: 10.1016/J.Jalz.2013.04.051  0.509
2012 Hashimoto T, Serrano-Pozo A, Hori Y, Adams KW, Takeda S, Banerji AO, Mitani A, Joyner D, Thyssen DH, Bacskai BJ, Frosch MP, Spires-Jones TL, Finn MB, Holtzman DM, Hyman BT. Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15181-92. PMID 23100439 DOI: 10.1523/Jneurosci.1542-12.2012  0.813
2012 Tai HC, Serrano-Pozo A, Hashimoto T, Frosch MP, Spires-Jones TL, Hyman BT. The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system. The American Journal of Pathology. 181: 1426-35. PMID 22867711 DOI: 10.1016/J.Ajpath.2012.06.033  0.8
2012 Koffie RM, Hashimoto T, Tai HC, Kay KR, Serrano-Pozo A, Joyner D, Hou S, Kopeikina KJ, Frosch MP, Lee VM, Holtzman DM, Hyman BT, Spires-Jones TL. Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β. Brain : a Journal of Neurology. 135: 2155-68. PMID 22637583 DOI: 10.1093/Brain/Aws127  0.804
2012 Wu HY, Hudry E, Hashimoto T, Uemura K, Fan ZY, Berezovska O, Grosskreutz CL, Bacskai BJ, Hyman BT. Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-β revealed by a novel fluorescence resonance energy transfer assay. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 5298-309. PMID 22496575 DOI: 10.1523/Jneurosci.0227-12.2012  0.543
2012 Hudry E, Wu HY, Arbel-Ornath M, Hashimoto T, Matsouaka R, Fan Z, Spires-Jones TL, Betensky RA, Bacskai BJ, Hyman BT. Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 3176-92. PMID 22378890 DOI: 10.1523/Jneurosci.6439-11.2012  0.714
2012 Ofengeim D, Shi P, Miao B, Fan J, Xia X, Fan Y, Lipinski MM, Hashimoto T, Polydoro M, Yuan J, Wong ST, Degterev A. Identification of small molecule inhibitors of neurite loss induced by Aβ peptide using high content screening. The Journal of Biological Chemistry. 287: 8714-23. PMID 22277654 DOI: 10.1074/Jbc.M111.290957  0.735
2012 DaRocha-Souto B, Coma M, Pérez-Nievas BG, Scotton TC, Siao M, Sánchez-Ferrer P, Hashimoto T, Fan Z, Hudry E, Barroeta I, Serenó L, Rodríguez M, Sánchez MB, Hyman BT, Gómez-Isla T. Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease. Neurobiology of Disease. 45: 425-37. PMID 21945540 DOI: 10.1016/J.Nbd.2011.09.002  0.645
2011 Hashimoto T, Adams KW, Fan Z, McLean PJ, Hyman BT. Characterization of oligomer formation of amyloid-beta peptide using a split-luciferase complementation assay. The Journal of Biological Chemistry. 286: 27081-91. PMID 21652708 DOI: 10.1074/Jbc.M111.257378  0.762
2011 Fujiyoshi M, Tachikawa M, Ohtsuki S, Ito S, Uchida Y, Akanuma S, Kamiie J, Hashimoto T, Hosoya K, Iwatsubo T, Terasaki T. Amyloid-β peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier. Journal of Neurochemistry. 118: 407-15. PMID 21585370 DOI: 10.1111/J.1471-4159.2011.07311.X  0.536
2011 DaRocha-Souto B, Scotton TC, Coma M, Serrano-Pozo A, Hashimoto T, Serenó L, Rodríguez M, Sánchez B, Hyman BT, Gómez-Isla T. Brain oligomeric β-amyloid but not total amyloid plaque burden correlates with neuronal loss and astrocyte inflammatory response in amyloid precursor protein/tau transgenic mice. Journal of Neuropathology and Experimental Neurology. 70: 360-76. PMID 21487307 DOI: 10.1097/Nen.0B013E318217A118  0.784
2011 Jones PB, Adams KW, Rozkalne A, Spires-Jones TL, Hshieh TT, Hashimoto T, von Armin CA, Mielke M, Bacskai BJ, Hyman BT. Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain. Plos One. 6: e14586. PMID 21297948 DOI: 10.1371/Journal.Pone.0014586  0.715
2011 Danzer KM, Ruf WP, Putcha P, Joyner D, Hashimoto T, Glabe C, Hyman BT, McLean PJ. Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 326-36. PMID 20876215 DOI: 10.1096/Fj.10-164624  0.654
2011 Holtzman D, Hyman B, Lee V, Spires-Jones T, Koffie R, Hashimoto T, Joyner D, Hou S, Kopeikina K, Frosch M. O1-05-01: APOE4 plays a role in Abeta-mediated synapse loss in Alzheimer's disease Alzheimer's & Dementia. 7: S103-S104. DOI: 10.1016/J.Jalz.2011.05.256  0.69
2011 Hudry E, Hashimoto T, Scheel M, Dashkoff J, Spires-Jones T, Bacskai B, Davidson B, Hyman B. P2-465: Changes in the progression of amyloid deposition in APP/PS mice after overexpression of different ApoE isoforms through intraventricular injection of an adeno-associated virus serotype 4 Alzheimer's & Dementia. 7: S461-S462. DOI: 10.1016/J.Jalz.2011.05.1337  0.685
2010 Uemura K, Farner KC, Hashimoto T, Nasser-Ghodsi N, Wolfe MS, Koo EH, Hyman BT, Berezovska O. Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site. Nature Communications. 1: 130. PMID 21119643 DOI: 10.1038/Ncomms1129  0.486
2010 Wu HY, Hudry E, Hashimoto T, Kuchibhotla K, Rozkalne A, Fan Z, Spires-Jones T, Xie H, Arbel-Ornath M, Grosskreutz CL, Bacskai BJ, Hyman BT. Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 2636-49. PMID 20164348 DOI: 10.1523/Jneurosci.4456-09.2010  0.749
2009 Yamada K, Yabuki C, Seubert P, Schenk D, Hori Y, Ohtsuki S, Terasaki T, Hashimoto T, Iwatsubo T. Abeta immunotherapy: intracerebral sequestration of Abeta by an anti-Abeta monoclonal antibody 266 with high affinity to soluble Abeta. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 11393-8. PMID 19741145 DOI: 10.1523/Jneurosci.2021-09.2009  0.594
2009 Koffie RM, Meyer-Luehmann M, Hashimoto T, Adams KW, Mielke ML, Garcia-Alloza M, Micheva KD, Smith SJ, Kim ML, Lee VM, Hyman BT, Spires-Jones TL. Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques. Proceedings of the National Academy of Sciences of the United States of America. 106: 4012-7. PMID 19228947 DOI: 10.1073/Pnas.0811698106  0.727
2008 Yamada K, Hashimoto T, Yabuki C, Nagae Y, Tachikawa M, Strickland DK, Liu Q, Bu G, Basak JM, Holtzman DM, Ohtsuki S, Terasaki T, Iwatsubo T. The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells. The Journal of Biological Chemistry. 283: 34554-62. PMID 18940800 DOI: 10.1074/Jbc.M801487200  0.523
2008 Akanuma S, Ohtsuki S, Doi Y, Tachikawa M, Ito S, Hori S, Asashima T, Hashimoto T, Yamada K, Ueda K, Iwatsubo T, Terasaki T. ATP-binding cassette transporter A1 (ABCA1) deficiency does not attenuate the brain-to-blood efflux transport of human amyloid-beta peptide (1-40) at the blood-brain barrier. Neurochemistry International. 52: 956-61. PMID 18201804 DOI: 10.1016/J.Neuint.2007.12.002  0.52
2008 Yoshihara T, Takiguchi S, Kyuno A, Tanaka K, Kuba S, Hashiguchi S, Ito Y, Hashimoto T, Iwatsubo T, Tsuyama S, Nakashima T, Sugimura K. Immunoreactivity of phage library-derived human single-chain antibodies to amyloid beta conformers in vitro. Journal of Biochemistry. 143: 475-86. PMID 18174189 DOI: 10.1093/Jb/Mvm239  0.466
2008 Hori Y, Hashimoto T, Nomoto H, Iwatsubo T. P1-478: Isoform-specific effects of apolipoprotein E on the stability of Abeta protofibrils Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1061  0.524
2007 Kato M, Kinoshita H, Enokita M, Hori Y, Hashimoto T, Iwatsubo T, Toyo'oka T. Analytical method for beta-amyloid fibrils using CE-laser induced fluorescence and its application to screening for inhibitors of beta-amyloid protein aggregation. Analytical Chemistry. 79: 4887-91. PMID 17536782 DOI: 10.1021/Ac0701482  0.587
2007 Hori Y, Hashimoto T, Wakutani Y, Urakami K, Nakashima K, Condron MM, Tsubuki S, Saido TC, Teplow DB, Iwatsubo T. The Tottori (D7N) and English (H6R) familial Alzheimer disease mutations accelerate Abeta fibril formation without increasing protofibril formation. The Journal of Biological Chemistry. 282: 4916-23. PMID 17170111 DOI: 10.1074/Jbc.M608220200  0.602
2006 Tamaki C, Ohtsuki S, Iwatsubo T, Hashimoto T, Yamada K, Yabuki C, Terasaki T. Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid beta-peptide by the liver. Pharmaceutical Research. 23: 1407-16. PMID 16779710 DOI: 10.1007/S11095-006-0208-7  0.532
2006 Hashimoto T, Fujii D, Matsuo Y, Matsuura Y, Westaway D, Iwatsubo T. P1-114: Pathological effects of CLAC in the brains of APP/CLAC-P double transgenic mice Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.490  0.525
2006 Yamada K, Yabuki C, Tachikawa M, Ohtsuki S, Strickland DK, Bu G, Terasaki T, Hashimoto T, Iwatsubo T. AbstractPoster presentation: Wednesday posterP4-069: Modeling amyloid β-peptide transport across the blood-brain barrier in TR-BBB cells Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1807  0.523
2005 Osada Y, Hashimoto T, Nishimura A, Matsuo Y, Wakabayashi T, Iwatsubo T. CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils. The Journal of Biological Chemistry. 280: 8596-605. PMID 15615705 DOI: 10.1074/Jbc.M413340200  0.628
2004 Kowa H, Sakakura T, Matsuura Y, Wakabayashi T, Mann DM, Duff K, Tsuji S, Hashimoto T, Iwatsubo T. Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits. The American Journal of Pathology. 165: 273-81. PMID 15215182 DOI: 10.1016/S0002-9440(10)63295-6  0.629
2004 Kowa H, Sakakura T, Matsuura Y, Wakabayashi T, Tsuji S, Mann DM, Hashimoto T, Iwatsubo T. P1-235 CLAC-positive senile plaques in Alzheimer brains: mutually exclusive distribution to Aβ40 and acquisition of protease resistance Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80548-7  0.595
2003 Söderberg L, Zhukareva V, Bogdanovic N, Hashimoto T, Winblad B, Iwatsubo T, Lee VM, Trojanowski JQ, Näslund J. Molecular identification of AMY, an Alzheimer disease amyloid-associated protein. Journal of Neuropathology and Experimental Neurology. 62: 1108-17. PMID 14656069 DOI: 10.1093/Jnen/62.11.1108  0.639
2002 Hashimoto T, Wakabayashi T, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DM, Iwatsubo T. CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV. The Embo Journal. 21: 1524-34. PMID 11927537 DOI: 10.1093/Emboj/21.7.1524  0.63
1999 Nakai M, Hojo K, Taniguchi T, Terashima A, Kawamata T, Hashimoto T, Maeda K, Tanaka C. PKC and tyrosine kinase involvement in amyloid beta (25-35)-induced chemotaxis of microglia. Neuroreport. 9: 3467-70. PMID 9855300 DOI: 10.1097/00001756-199810260-00024  0.351
1998 Tomita T, Tokuhiro S, Hashimoto T, Aiba K, Saido TC, Maruyama K, Iwatsubo T. Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42. The Journal of Biological Chemistry. 273: 21153-60. PMID 9694871 DOI: 10.1074/Jbc.273.33.21153  0.668
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