Tadafumi Hashimoto - Publications

Affiliations: 
The University of Tokyo (Japan) 
Area:
Alzheimer's disease, Neurodegenerative disorders

43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Wakabayashi T, Yamaguchi K, Matsui K, Sano T, Kubota T, Hashimoto T, Mano A, Yamada K, Matsuo Y, Kubota N, Kadowaki T, Iwatsubo T. Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer's disease. Molecular Neurodegeneration. 14: 15. PMID 30975165 DOI: 10.1186/s13024-019-0315-7  0.44
2019 Bannai T, Mano T, Chen X, Ohtomo G, Ohtomo R, Tsuchida T, Koshi-Mano K, Hashimoto T, Okazawa H, Iwatsubo T, Tsuji S, Toda T, Iwata A. Chronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight. Scientific Reports. 9: 2827. PMID 30808940 DOI: 10.1038/s41598-019-39494-7  0.44
2018 Mann DMA, Davidson YS, Robinson AC, Allen N, Hashimoto T, Richardson A, Jones M, Snowden JS, Pendleton N, Potier MC, Laquerrière A, Prasher V, Iwatsubo T, Strydom A. Patterns and severity of vascular amyloid in Alzheimer's disease associated with duplications and missense mutations in APP gene, Down syndrome and sporadic Alzheimer's disease. Acta Neuropathologica. PMID 29770843 DOI: 10.1007/s00401-018-1866-3  0.44
2018 Hori Y, Hashimoto T, Nomoto H, Hyman BT, Iwatsubo T. Role of apolipoprotein E in β-amyloidogenesis: Isoform-specific effects on protofibril to fibril conversion of Aβ and brain Aβ deposition . The Journal of Biological Chemistry. 293: 7267. PMID 29752420 DOI: 10.1074/jbc.AAC118.003576  0.44
2018 Matsumoto T, Matsukawa K, Watanabe N, Kishino Y, Kunugi H, Ihara R, Wakabayashi T, Hashimoto T, Iwatsubo T. Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration. Human Molecular Genetics. PMID 29425337 DOI: 10.1093/hmg/ddy046  0.44
2017 Mano T, Nagata K, Nonaka T, Tarutani A, Imamura T, Hashimoto T, Bannai T, Koshi-Mano K, Tsuchida T, Ohtomo R, Takahashi-Fujigasaki J, Yamashita S, Ohyagi Y, Yamasaki R, Tsuji S, et al. Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 29042514 DOI: 10.1073/pnas.1707151114  0.44
2017 Arbel-Ornath M, Hudry E, Boivin JR, Hashimoto T, Takeda S, Kuchibhotla KV, Hou S, Lattarulo CR, Belcher AM, Shakerdge N, Trujillo PB, Muzikansky A, Betensky RA, Hyman BT, Bacskai BJ. Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain. Molecular Neurodegeneration. 12: 27. PMID 28327181 DOI: 10.1186/s13024-017-0169-9  0.44
2016 Matsukawa K, Hashimoto T, Matsumoto T, Ihara R, Chihara T, Miura M, Wakabayashi T, Iwatsubo T. Familial ALS-linked Mutations in Profilin 1 Exacerbate TDP-43-induced Degeneration in the Retina of Drosophila Melanogaster through an Increase in the Cytoplasmic Localization of TDP-43. The Journal of Biological Chemistry. PMID 27634045 DOI: 10.1074/jbc.M116.729152  0.44
2015 Hori Y, Hashimoto T, Nomoto H, Hyman BT, Iwatsubo T. Role of Apolipoprotein E in β-Amyloidogenesis: ISOFORM-SPECIFIC EFFECTS ON PROTOFIBRIL TO FIBRIL CONVERSION OF Aβ IN VITRO AND BRAIN Aβ DEPOSITION IN VIVO. The Journal of Biological Chemistry. 290: 15163-74. PMID 25918154 DOI: 10.1074/jbc.M114.622209  0.44
2015 Kukharsky MS, Quintiero A, Matsumoto T, Matsukawa K, An H, Hashimoto T, Iwatsubo T, Buchman VL, Shelkovnikova TA. Calcium-responsive transactivator (CREST) protein shares a set of structural and functional traits with other proteins associated with amyotrophic lateral sclerosis. Molecular Neurodegeneration. 10: 20. PMID 25888396 DOI: 10.1186/s13024-015-0014-y  0.44
2014 Farrar CT, William CM, Hudry E, Hashimoto T, Hyman BT. RNA aptamer probes as optical imaging agents for the detection of amyloid plaques. Plos One. 9: e89901. PMID 24587111 DOI: 10.1371/journal.pone.0089901  0.44
2014 Tanaka T, Wakabayashi T, Oizumi H, Nishio S, Sato T, Harada A, Fujii D, Matsuo Y, Hashimoto T, Iwatsubo T. CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 1370-9. PMID 24453327 DOI: 10.1523/JNEUROSCI.2440-13.2014  0.44
2013 Iwatsubo T, Hashimoto T, Wakabayashi T, Tomita T, Morohashi Y. [Alzheimer disease: experimental approaches to genetic and environmental risk factors]. Rinshō Shinkeigaku = Clinical Neurology. 53: 956. PMID 24291845 DOI: DN/JST.JSTAGE/clinicalneurol/53.956  0.44
2013 Hudry E, Dashkoff J, Roe AD, Takeda S, Koffie RM, Hashimoto T, Scheel M, Spires-Jones T, Arbel-Ornath M, Betensky R, Davidson BL, Hyman BT. Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain. Science Translational Medicine. 5: 212ra161. PMID 24259049 DOI: 10.1126/scitranslmed.3007000  0.44
2013 Ihara R, Matsukawa K, Nagata Y, Kunugi H, Tsuji S, Chihara T, Kuranaga E, Miura M, Wakabayashi T, Hashimoto T, Iwatsubo T. RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy. Human Molecular Genetics. 22: 4474-84. PMID 23804749 DOI: 10.1093/hmg/ddt296  0.44
2013 Cho H, Hashimoto T, Wong E, Hori Y, Wood LB, Zhao L, Haigis KM, Hyman BT, Irimia D. Microfluidic chemotaxis platform for differentiating the roles of soluble and bound amyloid-β on microglial accumulation. Scientific Reports. 3: 1823. PMID 23665843 DOI: 10.1038/srep01823  0.44
2013 Takeda S, Hashimoto T, Roe AD, Hori Y, Spires-Jones TL, Hyman BT. Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 3239-48. PMID 23640054 DOI: 10.1096/fj.13-229666  0.44
2013 Li X, Uemura K, Hashimoto T, Nasser-Ghodsi N, Arimon M, Lill CM, Palazzolo I, Krainc D, Hyman BT, Berezovska O. Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions. Neurobiology of Disease. 50: 127-34. PMID 23064434 DOI: 10.1016/j.nbd.2012.10.002  0.44
2012 Hashimoto T, Serrano-Pozo A, Hori Y, Adams KW, Takeda S, Banerji AO, Mitani A, Joyner D, Thyssen DH, Bacskai BJ, Frosch MP, Spires-Jones TL, Finn MB, Holtzman DM, Hyman BT. Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15181-92. PMID 23100439 DOI: 10.1523/JNEUROSCI.1542-12.2012  0.44
2012 Tai HC, Serrano-Pozo A, Hashimoto T, Frosch MP, Spires-Jones TL, Hyman BT. The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system. The American Journal of Pathology. 181: 1426-35. PMID 22867711 DOI: 10.1016/j.ajpath.2012.06.033  0.44
2012 Koffie RM, Hashimoto T, Tai HC, Kay KR, Serrano-Pozo A, Joyner D, Hou S, Kopeikina KJ, Frosch MP, Lee VM, Holtzman DM, Hyman BT, Spires-Jones TL. Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β. Brain : a Journal of Neurology. 135: 2155-68. PMID 22637583 DOI: 10.1093/brain/aws127  0.44
2012 Wu HY, Hudry E, Hashimoto T, Uemura K, Fan ZY, Berezovska O, Grosskreutz CL, Bacskai BJ, Hyman BT. Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-β revealed by a novel fluorescence resonance energy transfer assay. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 5298-309. PMID 22496575 DOI: 10.1523/JNEUROSCI.0227-12.2012  0.44
2012 Hudry E, Wu HY, Arbel-Ornath M, Hashimoto T, Matsouaka R, Fan Z, Spires-Jones TL, Betensky RA, Bacskai BJ, Hyman BT. Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 3176-92. PMID 22378890 DOI: 10.1523/JNEUROSCI.6439-11.2012  0.44
2012 Ofengeim D, Shi P, Miao B, Fan J, Xia X, Fan Y, Lipinski MM, Hashimoto T, Polydoro M, Yuan J, Wong ST, Degterev A. Identification of small molecule inhibitors of neurite loss induced by Aβ peptide using high content screening. The Journal of Biological Chemistry. 287: 8714-23. PMID 22277654 DOI: 10.1074/jbc.M111.290957  0.44
2011 Hashimoto T, Adams KW, Fan Z, McLean PJ, Hyman BT. Characterization of oligomer formation of amyloid-beta peptide using a split-luciferase complementation assay. The Journal of Biological Chemistry. 286: 27081-91. PMID 21652708 DOI: 10.1074/jbc.M111.257378  0.44
2011 Fujiyoshi M, Tachikawa M, Ohtsuki S, Ito S, Uchida Y, Akanuma S, Kamiie J, Hashimoto T, Hosoya K, Iwatsubo T, Terasaki T. Amyloid-β peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier. Journal of Neurochemistry. 118: 407-15. PMID 21585370 DOI: 10.1111/j.1471-4159.2011.07311.x  0.44
2011 DaRocha-Souto B, Scotton TC, Coma M, Serrano-Pozo A, Hashimoto T, Serenó L, Rodríguez M, Sánchez B, Hyman BT, Gómez-Isla T. Brain oligomeric β-amyloid but not total amyloid plaque burden correlates with neuronal loss and astrocyte inflammatory response in amyloid precursor protein/tau transgenic mice. Journal of Neuropathology and Experimental Neurology. 70: 360-76. PMID 21487307 DOI: 10.1097/NEN.0b013e318217a118  0.44
2011 Jones PB, Adams KW, Rozkalne A, Spires-Jones TL, Hshieh TT, Hashimoto T, von Armin CA, Mielke M, Bacskai BJ, Hyman BT. Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain. Plos One. 6: e14586. PMID 21297948 DOI: 10.1371/journal.pone.0014586  0.44
2011 Danzer KM, Ruf WP, Putcha P, Joyner D, Hashimoto T, Glabe C, Hyman BT, McLean PJ. Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 326-36. PMID 20876215 DOI: 10.1096/fj.10-164624  0.44
2010 Uemura K, Farner KC, Hashimoto T, Nasser-Ghodsi N, Wolfe MS, Koo EH, Hyman BT, Berezovska O. Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site. Nature Communications. 1: 130. PMID 21119643 DOI: 10.1038/ncomms1129  0.44
2010 Wu HY, Hudry E, Hashimoto T, Kuchibhotla K, Rozkalne A, Fan Z, Spires-Jones T, Xie H, Arbel-Ornath M, Grosskreutz CL, Bacskai BJ, Hyman BT. Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 2636-49. PMID 20164348 DOI: 10.1523/JNEUROSCI.4456-09.2010  0.44
2009 Yamada K, Yabuki C, Seubert P, Schenk D, Hori Y, Ohtsuki S, Terasaki T, Hashimoto T, Iwatsubo T. Abeta immunotherapy: intracerebral sequestration of Abeta by an anti-Abeta monoclonal antibody 266 with high affinity to soluble Abeta. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 11393-8. PMID 19741145 DOI: 10.1523/JNEUROSCI.2021-09.2009  0.44
2009 Koffie RM, Meyer-Luehmann M, Hashimoto T, Adams KW, Mielke ML, Garcia-Alloza M, Micheva KD, Smith SJ, Kim ML, Lee VM, Hyman BT, Spires-Jones TL. Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques. Proceedings of the National Academy of Sciences of the United States of America. 106: 4012-7. PMID 19228947 DOI: 10.1073/pnas.0811698106  0.44
2008 Yamada K, Hashimoto T, Yabuki C, Nagae Y, Tachikawa M, Strickland DK, Liu Q, Bu G, Basak JM, Holtzman DM, Ohtsuki S, Terasaki T, Iwatsubo T. The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells. The Journal of Biological Chemistry. 283: 34554-62. PMID 18940800 DOI: 10.1074/jbc.M801487200  0.44
2008 Akanuma S, Ohtsuki S, Doi Y, Tachikawa M, Ito S, Hori S, Asashima T, Hashimoto T, Yamada K, Ueda K, Iwatsubo T, Terasaki T. ATP-binding cassette transporter A1 (ABCA1) deficiency does not attenuate the brain-to-blood efflux transport of human amyloid-beta peptide (1-40) at the blood-brain barrier. Neurochemistry International. 52: 956-61. PMID 18201804 DOI: 10.1016/j.neuint.2007.12.002  0.44
2008 Yoshihara T, Takiguchi S, Kyuno A, Tanaka K, Kuba S, Hashiguchi S, Ito Y, Hashimoto T, Iwatsubo T, Tsuyama S, Nakashima T, Sugimura K. Immunoreactivity of phage library-derived human single-chain antibodies to amyloid beta conformers in vitro. Journal of Biochemistry. 143: 475-86. PMID 18174189 DOI: 10.1093/jb/mvm239  0.44
2007 Kato M, Kinoshita H, Enokita M, Hori Y, Hashimoto T, Iwatsubo T, Toyo'oka T. Analytical method for beta-amyloid fibrils using CE-laser induced fluorescence and its application to screening for inhibitors of beta-amyloid protein aggregation. Analytical Chemistry. 79: 4887-91. PMID 17536782 DOI: 10.1021/ac0701482  0.44
2007 Hori Y, Hashimoto T, Wakutani Y, Urakami K, Nakashima K, Condron MM, Tsubuki S, Saido TC, Teplow DB, Iwatsubo T. The Tottori (D7N) and English (H6R) familial Alzheimer disease mutations accelerate Abeta fibril formation without increasing protofibril formation. The Journal of Biological Chemistry. 282: 4916-23. PMID 17170111 DOI: 10.1074/jbc.M608220200  0.44
2006 Tamaki C, Ohtsuki S, Iwatsubo T, Hashimoto T, Yamada K, Yabuki C, Terasaki T. Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid beta-peptide by the liver. Pharmaceutical Research. 23: 1407-16. PMID 16779710 DOI: 10.1007/s11095-006-0208-7  0.44
2005 Osada Y, Hashimoto T, Nishimura A, Matsuo Y, Wakabayashi T, Iwatsubo T. CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils. The Journal of Biological Chemistry. 280: 8596-605. PMID 15615705 DOI: 10.1074/jbc.M413340200  0.44
2004 Kowa H, Sakakura T, Matsuura Y, Wakabayashi T, Mann DM, Duff K, Tsuji S, Hashimoto T, Iwatsubo T. Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits. The American Journal of Pathology. 165: 273-81. PMID 15215182  0.44
2003 Söderberg L, Zhukareva V, Bogdanovic N, Hashimoto T, Winblad B, Iwatsubo T, Lee VM, Trojanowski JQ, Näslund J. Molecular identification of AMY, an Alzheimer disease amyloid-associated protein. Journal of Neuropathology and Experimental Neurology. 62: 1108-17. PMID 14656069  0.44
2002 Hashimoto T, Wakabayashi T, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DM, Iwatsubo T. CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV. The Embo Journal. 21: 1524-34. PMID 11927537 DOI: 10.1093/emboj/21.7.1524  0.44
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