Xinzhong Dong - Publications

Neuroscience Johns Hopkins University School of Medicine, Baltimore, MD, United States 

108 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Wang F, Trier AM, Li F, Kim S, Chen Z, Chai JN, Mack MR, Morrison SA, Hamilton JD, Baek J, Yang TB, Ver Heul AM, Xu AZ, Xie Z, Dong X, ... ... Dong X, et al. A basophil-neuronal axis promotes itch. Cell. PMID 33450207 DOI: 10.1016/j.cell.2020.12.033  1
2020 Meixiong J, Dong X, Weng HJ. Neuropathic Itch. Cells. 9. PMID 33050211 DOI: 10.3390/cells9102263  0.64
2020 Gao X, Han S, Huang Q, He S, Ford NC, Zheng Q, Chen Z, Yu S, Dong X, Guan Y. Calcium imaging in population of dorsal root ganglion neurons unravels novel mechanisms of visceral pain sensitization and referred somatic hypersensitivity. Pain. PMID 33021564 DOI: 10.1097/j.pain.0000000000002096  0.68
2020 Barpujari A, Ford N, He SQ, Huang Q, Gaveriaux-Ruff C, Dong X, Guan Y, Raja S. Role of peripheral sensory neuron mu-opioid receptors in nociceptive, inflammatory, and neuropathic pain. Regional Anesthesia and Pain Medicine. PMID 32928995 DOI: 10.1136/rapm-2020-101779  0.68
2020 Patil MJ, Ru F, Sun H, Wang J, Kolbeck R, Dong X, Kollarik M, Canning BJ, Undem BJ. Acute activation of bronchopulmonary vagal nociceptors by type I interferons. The Journal of Physiology. PMID 32924209 DOI: 10.1113/JP280276  0.52
2020 Zhu J, Zhen G, An S, Wang X, Wan M, Li Y, Chen Z, Guan Y, Dong X, Hu Y, Cao X. Aberrant subchondral osteoblastic metabolism modifies NaV1.8 for osteoarthritis. Elife. 9. PMID 32441256 DOI: 10.7554/eLife.57656  0.68
2020 Meixiong J, Basso L, Dong X, Gaudenzio N. Nociceptor-Mast Cell Sensory Clusters as Regulators of Skin Homeostasis. Trends in Neurosciences. PMID 32014258 DOI: 10.1016/j.tins.2020.01.001  0.36
2020 Ni S, Ling Z, Wang X, Cao Y, Wu T, Deng R, Crane JL, Skolasky R, Demehri S, Zhen G, Jain A, Wu P, Pan D, Hu B, Lyu X, ... ... Dong X, et al. Author Correction: Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice. Nature Communications. 11: 149. PMID 31907358 DOI: 10.1038/s41467-019-13970-0  0.68
2019 Tseng PY, Zheng Q, Li Z, Dong X. MrgprX1 Mediates Neuronal Excitability and Itch Through Tetrodotoxin-Resistant Sodium Channels. Itch (Philadelphia, Pa.). 4. PMID 33442562 DOI: 10.1097/itx.0000000000000028  0.4
2019 Ni S, Ling Z, Wang X, Cao Y, Wu T, Deng R, Crane JL, Skolask R, Demehril S, Zhen G, Jain A, Wu P, Pan D, Hu B, Lyu X, ... ... Dong X, et al. Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice. Nature Communications. 10: 5643. PMID 31822662 DOI: 10.1038/s41467-019-13476-9  0.68
2019 Tiwari V, He SQ, Huang Q, Liang L, Yang F, Chen Z, Tiwari V, Fujita W, Devi LA, Dong X, Guan Y, Raja SN. Activation of µ-δ opioid receptor heteromers inhibits neuropathic pain behavior in rodents. Pain. PMID 31815916 DOI: 10.1097/j.pain.0000000000001768  0.68
2019 Serhan N, Basso L, Sibilano R, Petitfils C, Meixiong J, Bonnart C, Reber LL, Marichal T, Starkl P, Cenac N, Dong X, Tsai M, Galli SJ, Gaudenzio N. House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation. Nature Immunology. PMID 31591569 DOI: 10.1038/s41590-019-0493-z  0.36
2019 Prchalová E, Hin N, Thomas AG, Veeravalli V, Ng J, Alt J, Rais R, Rojas C, Li Z, Hihara H, Aoki M, Yoshizawa K, Nishioka T, Suzuki S, Kopajtic T, ... ... Dong X, et al. Discovery of Benzamidine- and 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists. Journal of Medicinal Chemistry. PMID 31498617 DOI: 10.1021/acs.jmedchem.9b01003  1
2019 Zhang T, Liu R, Che D, Pundir P, Wang N, Han S, Cao J, Lv Y, Dong H, Fang F, Wang J, Ma P, Zhao T, Lei T, Dong X, et al. A Mast Cell-Specific Receptor Is Critical for Granuloma Induced by Intrathecal Morphine Infusion. Journal of Immunology (Baltimore, Md. : 1950). PMID 31484729 DOI: 10.4049/jimmunol.1801423  0.44
2019 Green D, Dong X. A Pungent and Painful Toxin. Cell. 178: 1279-1281. PMID 31474364 DOI: 10.1016/j.cell.2019.08.016  0.32
2019 Pundir P, Liu R, Vasavda C, Serhan N, Limjunyawong N, Yee R, Zhan Y, Dong X, Wu X, Zhang Y, Snyder SH, Gaudenzio N, Vidal JE, Dong X. A Connective Tissue Mast-Cell-Specific Receptor Detects Bacterial Quorum-Sensing Molecules and Mediates Antibacterial Immunity. Cell Host & Microbe. PMID 31278040 DOI: 10.1016/j.chom.2019.06.003  0.36
2019 Wang L, Jiang X, Zheng Q, Jeon SM, Chen T, Liu Y, Kulaga H, Reed R, Dong X, Caterina MJ, Qu L. Neuronal FcγRI mediates acute and chronic joint pain. The Journal of Clinical Investigation. 130. PMID 31211699 DOI: 10.1172/JCI128010  0.44
2019 Chen Z, Wang T, Fang Y, Luo D, Anderson M, Huang Q, He S, Song X, Cui H, Dong X, Xie Y, Guan Y, Ma C. Adjacent intact nociceptive neurons drive the acute outburst of pain following peripheral axotomy. Scientific Reports. 9: 7651. PMID 31113988 DOI: 10.1038/s41598-019-44172-9  0.68
2019 Marchitto MC, Dillen CA, Liu H, Miller RJ, Archer NK, Ortines RV, Alphonse MP, Marusina AI, Merleev AA, Wang Y, Pinsker BL, Byrd AS, Brown ID, Ravipati A, Zhang E, ... ... Dong X, et al. Clonal Vγ6Vδ4 T cells promote IL-17-mediated immunity against skin infection. Proceedings of the National Academy of Sciences of the United States of America. PMID 31088972 DOI: 10.1073/pnas.1818256116  0.36
2019 Meixiong J, Vasavda C, Snyder SH, Dong X. MRGPRX4 is a G protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus. Proceedings of the National Academy of Sciences of the United States of America. PMID 31068464 DOI: 10.1073/pnas.1903316116  0.36
2019 Meixiong J, Anderson M, Limjunyawong N, Sabbagh MF, Hu E, Mack MR, Oetjen LK, Wang F, Kim BS, Dong X. Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch. Immunity. PMID 31027996 DOI: 10.1016/j.immuni.2019.03.013  0.36
2019 Patel SP, Vasavda C, Ho B, Meixiong J, Dong X, Kwatra SG. Cholestatic pruritus: Emerging mechanisms and therapeutics. Journal of the American Academy of Dermatology. PMID 31009666 DOI: 10.1016/j.jaad.2019.04.035  0.36
2019 Huang Y, Patil MJ, Yu M, Liptak P, Undem BJ, Dong X, Wang G, Yu S. Effects of ginger constituent 6-shogaol on gastroesophageal vagal afferent C-fibers. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. e13585. PMID 30947399 DOI: 10.1111/nmo.13585  0.52
2019 Xu Q, Dong X. Calcium imaging approaches in investigation of pain mechanism in the spinal cord. Experimental Neurology. PMID 30853387 DOI: 10.1016/j.expneurol.2019.03.002  0.32
2019 Patil MJ, Meeker S, Bautista D, Dong X, Undem BJ. Sphingosine-1-phosphate activates mouse vagal airway afferent C-fibres via S1PR3 receptors. The Journal of Physiology. PMID 30793318 DOI: 10.1113/JP277521  0.52
2019 Meixiong J, Vasavda C, Green D, Zheng Q, Qi L, Kwatra SG, Hamilton JP, Snyder SH, Dong X. Identification of a bilirubin receptor may mediate a component of cholestatic itch. Elife. 8. PMID 30657454 DOI: 10.7554/eLife.44116  0.36
2019 Chen H, Hu B, Lv X, Zhu S, Zhen G, Wan M, Jain A, Gao B, Chai Y, Yang M, Wang X, Deng R, Wang L, Cao Y, Ni S, ... ... Dong X, et al. Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis. Nature Communications. 10: 181. PMID 30643142 DOI: 10.1038/s41467-018-08097-7  0.68
2019 Liu X, Wang H, Jiang Y, Zheng Q, Petrus M, Zhang M, Zheng S, Schmedt C, Dong X, Xiao B. STIM1 thermosensitivity defines the optimal preference temperature for warm sensation in mice. Cell Research. PMID 30607017 DOI: 10.1038/s41422-018-0129-0  0.36
2018 Zhu S, Zhu J, Zhen G, Hu Y, An S, Li Y, Zheng Q, Chen Z, Yang Y, Wan M, Skolasky RL, Cao Y, Wu T, Gao B, Yang M, ... ... Dong X, et al. Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain. The Journal of Clinical Investigation. PMID 30530994 DOI: 10.1172/JCI121561  0.68
2018 Salvatierra J, Diaz-Bustamante M, Meixiong J, Tierney E, Dong X, Bosmans F. A disease mutation reveals a role for NaV1.9 in acute itch. The Journal of Clinical Investigation. PMID 30395542 DOI: 10.1172/JCI122481  0.36
2018 Wang C, Gu L, Ruan Y, Geng X, Xu M, Yang N, Yu L, Jiang Y, Zhu C, Yang Y, Zhou Y, Guan X, Luo W, Liu Q, Dong X, et al. Facilitation of MrgprD by TRP-A1 promotes neuropathic pain. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201800615RR. PMID 30148678 DOI: 10.1096/fj.201800615RR  1
2018 Geng X, Shi H, Ye F, Du H, Qian L, Gu L, Wu G, Zhu C, Yang Y, Wang C, Zhou Y, Yu G, Liu Q, Dong X, Yu L, et al. Matrine inhibits itching by lowering the activity of calcium channel. Scientific Reports. 8: 11328. PMID 30054511 DOI: 10.1038/s41598-018-28661-x  1
2018 He SQ, Xu Q, Tiwari V, Yang F, Anderson M, Chen Z, Grenald SA, Raja SN, Dong X, Guan Y. Oligomerization of MrgC11 and μ-opioid receptors in sensory neurons enhances morphine analgesia. Science Signaling. 11. PMID 29921657 DOI: 10.1126/scisignal.aao3134  0.68
2018 Jain S, Panyutin A, Liu N, Xiao C, Piñol RA, Pundir P, Girardet C, Butler AA, Dong X, Gavrilova O, Reitman ML. Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors. American Journal of Physiology. Endocrinology and Metabolism. PMID 29812984 DOI: 10.1152/ajpendo.00024.2018  0.44
2018 Tiwari V, Anderson M, Yang F, Tiwari V, Zheng Q, He SQ, Zhang T, Shu B, Chen X, Grenald SA, Stephens KE, Chen Z, Dong X, Raja SN, Guan Y. Peripherally Acting μ-Opioid Receptor Agonists Attenuate Ongoing Pain-associated Behavior and Spontaneous Neuronal Activity after Nerve Injury in Rats. Anesthesiology. PMID 29601322 DOI: 10.1097/ALN.0000000000002191  0.68
2018 Han L, Limjunyawong N, Ru F, Li Z, Hall OJ, Steele H, Zhu Y, Wilson J, Mitzner W, Kollarik M, Undem BJ, Canning BJ, Dong X. Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyper-responsiveness. Nature Neuroscience. PMID 29403029 DOI: 10.1038/s41593-018-0074-8  0.52
2017 Wang N, Che D, Zhang T, Liu R, Cao J, Wang J, Zhao T, Ma P, Dong X, He L. Saikosaponin A inhibits compound 48/80-induced pseudo-allergy via the Mrgprx2 pathway in vitro and in vivo. Biochemical Pharmacology. PMID 29274317 DOI: 10.1016/j.bcp.2017.12.017  0.44
2017 Meixiong J, Dong X. Mas-Related G Protein-Coupled Receptors and the Biology of Itch Sensation. Annual Review of Genetics. 51: 103-121. PMID 29178819 DOI: 10.1146/annurev-genet-120116-024723  0.36
2017 Han S, Lv Y, Kong L, Che D, Liu R, Fu J, Cao J, Wang J, Wang C, He H, Zhang T, Dong X, He L. Use of the relative release index for histamine in LAD2 cells to evaluate the potential anaphylactoid effects of drugs. Scientific Reports. 7: 13714. PMID 29057927 DOI: 10.1038/s41598-017-14224-z  0.44
2017 Liu R, Che D, Zhao T, Pundir P, Cao J, Lv Y, Wang J, Ma P, Fu J, Wang N, Wang X, Zhang T, Dong X, He L. MRGPRX2 is Essential for Sinomenine HydrochlorideInduced Anaphylactoid Reactions. Biochemical Pharmacology. PMID 28987593 DOI: 10.1016/j.bcp.2017.09.017  0.44
2017 Wang J, Kollarik M, Ru F, Sun H, McNeil B, Dong X, Stephens G, Korolevich S, Brohawn P, Kolbeck R, Undem B. Distinct and common expression of receptors for inflammatory mediators in vagal nodose versus jugular capsaicin-sensitive/TRPV1-positive neurons detected by low input RNA sequencing. Plos One. 12: e0185985. PMID 28982197 DOI: 10.1371/journal.pone.0185985  0.44
2017 Zhang T, Che D, Liu R, Han S, Wang N, Zhan Y, Pundir P, Cao J, Lv Y, Yang L, Wang J, Ding M, Dong X, He L. Typical antimicrobials induce mast cell degranulation and anaphylactoid reactions via MRGPRX2 and its murine homologue MRGPRB2. European Journal of Immunology. PMID 28688196 DOI: 10.1002/eji.201746951  0.44
2017 Anderson M, Zheng Q, Dong X. Investigation of Pain Mechanisms by Calcium Imaging Approaches. Neuroscience Bulletin. PMID 28501905 DOI: 10.1007/s12264-017-0139-9  0.36
2017 Yuan X, Li Z, Baines AC, Gavriilaki E, Ye Z, Wen Z, Braunstein EM, Biesecker LG, Cheng L, Dong X, Brodsky RA. A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model. Plos One. 12: e0174074. PMID 28441409 DOI: 10.1371/journal.pone.0174074  0.4
2017 Kulkarni S, Micci MA, Leser J, Shin C, Tang SC, Fu YY, Liu L, Li Q, Saha M, Li C, Enikolopov G, Becker L, Rakhilin N, Anderson M, Shen X, ... Dong X, et al. Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28420791 DOI: 10.1073/pnas.1619406114  0.32
2017 Sun S, Xu Q, Guo C, Guan Y, Liu Q, Dong X. Leaky Gate Model: Intensity-Dependent Coding of Pain and Itch in the Spinal Cord. Neuron. 93: 840-853.e5. PMID 28231466 DOI: 10.1016/j.neuron.2017.01.012  1
2017 Li Z, Tseng PY, Tiwari V, Xu Q, He SQ, Wang Y, Zheng Q, Han L, Wu Z, Blobaum AL, Cui Y, Tiwari V, Sun S, Cheng Y, Huang-Lionnet JH, ... ... Dong X, et al. Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain. Proceedings of the National Academy of Sciences of the United States of America. PMID 28223516 DOI: 10.1073/pnas.1615255114  0.72
2017 Ru F, Sun H, Jurcakova D, Herbstsomer RA, Meixong J, Dong X, Undem BJ. Mechanisms of pruritogen-induced activation of itch nerves in isolated mouse skin. The Journal of Physiology. PMID 28217875 DOI: 10.1113/JP273795  0.52
2016 Green D, Dong X. (296) MRGB2 contributes to mechanical and thermal allodynia in an animal model of postoperative pain. The Journal of Pain : Official Journal of the American Pain Society. 17: S50. PMID 28162537 DOI: 10.1016/j.jpain.2016.01.203  0.32
2016 Wang J, Xu W, Zhong T, Song Z, Zou Y, Ding Z, Guo Q, Dong X, Zou W. miR-365 targets β-arrestin 2 to reverse morphine tolerance in rats. Scientific Reports. 6: 38285. PMID 27922111 DOI: 10.1038/srep38285  0.44
2016 Yang F, Xu Q, Shu B, Tiwari V, He SQ, Vera-Portocarrero LP, Dong X, Linderoth B, Raja SN, Wang Y, Guan Y. Activation of cannabinoid CB1 receptor contributes to suppression of spinal nociceptive transmission and inhibition of mechanical hypersensitivity by Aβ-fiber stimulation. Pain. PMID 27589093 DOI: 10.1097/j.pain.0000000000000680  0.68
2016 Kim YS, Anderson M, Park K, Zheng Q, Agarwal A, Gong C, Saijilafu, Young L, He S, LaVinka PC, Zhou F, Bergles D, Hanani M, Guan Y, Spray DC, ... Dong X, et al. Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain. Neuron. PMID 27568517 DOI: 10.1016/j.neuron.2016.07.044  0.68
2016 Oh Y, Cho GS, Li Z, Hong I, Zhu R, Kim MJ, Kim YJ, Tampakakis E, Tung L, Huganir R, Dong X, Kwon C, Lee G. Functional Coupling with Cardiac Muscle Promotes Maturation of hPSC-Derived Sympathetic Neurons. Cell Stem Cell. PMID 27320040 DOI: 10.1016/j.stem.2016.05.002  0.4
2016 Rakhilin N, Barth B, Choi J, Muñoz NL, Kulkarni S, Jones JS, Small DM, Cheng YT, Cao Y, LaVinka C, Kan E, Dong X, Spencer M, Pasricha P, Nishimura N, et al. Simultaneous optical and electrical in vivo analysis of the enteric nervous system. Nature Communications. 7: 11800. PMID 27270085 DOI: 10.1038/ncomms11800  0.96
2016 Chang AY, Mann TS, McFawn PK, Han L, Dong X, Henry PJ. Investigating the role of MRGPRC11 and capsaicin-sensitive afferent nerves in the anti-influenza effects exerted by SLIGRL-amide in murine airways. Respiratory Research. 17: 62. PMID 27215903 DOI: 10.1186/s12931-016-0378-8  0.4
2016 Green D, Dong X. The cell biology of acute itch. The Journal of Cell Biology. 213: 155-61. PMID 27114499 DOI: 10.1083/jcb.201603042  0.32
2016 Tiwari V, Tiwari V, He S, Zhang T, Raja SN, Dong X, Guan Y. Mas-Related G Protein-Coupled Receptors Offer Potential New Targets for Pain Therapy. Advances in Experimental Medicine and Biology. 904: 87-103. PMID 26900065 DOI: 10.1007/978-94-017-7537-3_7  0.68
2016 Tang M, Wu G, Wang Z, Yang N, Shi H, He Q, Zhu C, Yang Y, Yu G, Wang C, Yuan X, Liu Q, Guan Y, Dong X, Tang Z. Voltage-gated potassium channels involved in regulation of physiological function in MrgprA3-specific itch neurons. Brain Research. PMID 26874069 DOI: 10.1016/j.brainres.2016.02.014  1
2016 Tiwari V, Yang F, He SQ, Shechter R, Zhang C, Shu B, Zhang T, Tiwari V, Wang Y, Dong X, Guan Y, Raja SN. Activation of Peripheral μ-opioid Receptors by Dermorphin [D-Arg2, Lys4] (1-4) Amide Leads to Modality-preferred Inhibition of Neuropathic Pain. Anesthesiology. PMID 26756519 DOI: 10.1097/ALN.0000000000000993  0.68
2015 Sun S, Dong X. Trp channels and itch. Seminars in Immunopathology. PMID 26385480 DOI: 10.1007/s00281-015-0530-4  0.96
2015 Wang C, Wang Z, Yang Y, Zhu C, Wu G, Yu G, Jian T, Yang N, Shi H, Tang M, He Q, Lan L, Liu Q, Guan Y, Dong X, et al. Pirt contributes to uterine contraction-induced pain in mice. Molecular Pain. 11: 57. PMID 26376721 DOI: 10.1186/s12990-015-0054-x  0.96
2015 Green D, Dong X. Supporting itch: a new role for astrocytes in chronic itch. Nature Medicine. 21: 841-2. PMID 26248264 DOI: 10.1038/nm.3921  0.32
2015 Reddy VB, Sun S, Azimi E, Elmariah SB, Dong X, Lerner EA. Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs. Nature Communications. 6: 7864. PMID 26216096 DOI: 10.1038/ncomms8864  0.4
2015 Sdrulla AD, Xu Q, He SQ, Tiwari V, Yang F, Zhang C, Shu B, Shechter R, Raja SN, Wang Y, Dong X, Guan Y. Electrical stimulation of low-threshold afferent fibers induces a prolonged synaptic depression in lamina II dorsal horn neurons to high-threshold afferent inputs in mice. Pain. 156: 1008-17. PMID 25974163 DOI: 10.1097/01.j.pain.0000460353.15460.a3  0.68
2015 Liu Q, Dong X. The role of the Mrgpr receptor family in itch. Handbook of Experimental Pharmacology. 226: 71-88. PMID 25861775 DOI: 10.1007/978-3-662-44605-8_5  1
2015 Pang Z, Sakamoto T, Tiwari V, Kim YS, Yang F, Dong X, Güler AD, Guan Y, Caterina MJ. Selective keratinocyte stimulation is sufficient to evoke nociception in mice. Pain. 156: 656-65. PMID 25790456 DOI: 10.1097/j.pain.0000000000000092  0.68
2015 Weng HJ, Patel KN, Jeske NA, Bierbower SM, Zou W, Tiwari V, Zheng Q, Tang Z, Mo GC, Wang Y, Geng Y, Zhang J, Guan Y, Akopian AN, Dong X. Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain. Neuron. 85: 833-46. PMID 25640077 DOI: 10.1016/j.neuron.2014.12.065  0.96
2015 McNeil BD, Pundir P, Meeker S, Han L, Undem BJ, Kulka M, Dong X. Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions. Nature. 519: 237-41. PMID 25517090 DOI: 10.1038/nature14022  0.96
2015 Yang F, Zhang C, Xu Q, Tiwari V, He SQ, Wang Y, Dong X, Vera-Portocarrero LP, Wacnik PW, Raja SN, Guan Y. Electrical stimulation of dorsal root entry zone attenuates wide-dynamic-range neuronal activity in rats. Neuromodulation : Journal of the International Neuromodulation Society. 18: 33-40; discussion 40. PMID 25308522 DOI: 10.1111/ner.12249  0.96
2015 Wen W, Wang Y, Li Z, Tseng PY, McManus OB, Wu M, Li M, Lindsley CW, Dong X, Hopkins CR. Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1. Chemmedchem. 10: 57-61. PMID 25209672 DOI: 10.1002/cmdc.201402277  0.96
2015 Green D, Dong X. Supporting itch: A new role for astrocytes in chronic itch Nature Medicine. 21: 841-842. DOI: 10.1038/nm.3921  0.96
2015 Reddy VB, Sun S, Azimi E, Elmariah SB, Dong X, Lerner EA. Redefining the concept of protease-activated receptors: Cathepsin S evokes itch via activation of Mrgprs Nature Communications. 6. DOI: 10.1038/ncomms8864  0.96
2014 Hin N, Alt J, Zimmermann SC, Delahanty G, Ferraris DV, Rojas C, Li F, Liu Q, Dong X, Slusher BS, Tsukamoto T. Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors. Bioorganic & Medicinal Chemistry. 22: 5831-7. PMID 25288495 DOI: 10.1016/j.bmc.2014.09.025  0.96
2014 Kim YJ, Lim H, Li Z, Oh Y, Kovlyagina I, Choi IY, Dong X, Lee G. Generation of multipotent induced neural crest by direct reprogramming of human postnatal fibroblasts with a single transcription factor. Cell Stem Cell. 15: 497-506. PMID 25158936 DOI: 10.1016/j.stem.2014.07.013  0.96
2014 Wooten M, Weng HJ, Hartke TV, Borzan J, Klein AH, Turnquist B, Dong X, Meyer RA, Ringkamp M. Three functionally distinct classes of C-fibre nociceptors in primates. Nature Communications. 5: 4122. PMID 24947823 DOI: 10.1038/ncomms5122  0.96
2014 Boitano S, Hoffman J, Tillu DV, Asiedu MN, Zhang Z, Sherwood CL, Wang Y, Dong X, Price TJ, Vagner J. Development and evaluation of small peptidomimetic ligands to protease-activated receptor-2 (PAR2) through the use of lipid tethering. Plos One. 9: e99140. PMID 24927179 DOI: 10.1371/journal.pone.0099140  0.96
2014 Han L, Dong X. Itch mechanisms and circuits. Annual Review of Biophysics. 43: 331-55. PMID 24819620 DOI: 10.1146/annurev-biophys-051013-022826  0.96
2014 Li Z, He SQ, Xu Q, Yang F, Tiwari V, Liu Q, Tang Z, Han L, Chu YX, Wang Y, Hin N, Tsukamoto T, Slusher B, Guan X, Wei F, ... ... Dong X, et al. Activation of MrgC receptor inhibits N-type calcium channels in small-diameter primary sensory neurons in mice. Pain. 155: 1613-21. PMID 24813294 DOI: 10.1016/j.pain.2014.05.008  0.96
2014 Qu L, Fan N, Ma C, Wang T, Han L, Fu K, Wang Y, Shimada SG, Dong X, LaMotte RH. Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain. Brain : a Journal of Neurology. 137: 1039-50. PMID 24549959 DOI: 10.1093/brain/awu007  0.96
2014 Kim YS, Chu Y, Han L, Li M, Li Z, Lavinka PC, Sun S, Tang Z, Park K, Caterina MJ, Ren K, Dubner R, Wei F, Dong X. Central terminal sensitization of TRPV1 by descending serotonergic facilitation modulates chronic pain. Neuron. 81: 873-87. PMID 24462040 DOI: 10.1016/j.neuron.2013.12.011  0.96
2014 LaMotte RH, Dong X, Ringkamp M. Sensory neurons and circuits mediating itch. Nature Reviews. Neuroscience. 15: 19-31. PMID 24356071 DOI: 10.1038/nrn3641  0.96
2014 He SQ, Li Z, Chu YX, Han L, Xu Q, Li M, Yang F, Liu Q, Tang Z, Wang Y, Hin N, Tsukamoto T, Slusher B, Tiwari V, Shechter R, ... ... Dong X, et al. MrgC agonism at central terminals of primary sensory neurons inhibits neuropathic pain. Pain. 155: 534-44. PMID 24333779 DOI: 10.1016/j.pain.2013.12.008  0.96
2013 Shechter R, Yang F, Xu Q, Cheong YK, He SQ, Sdrulla A, Carteret AF, Wacnik PW, Dong X, Meyer RA, Raja SN, Guan Y. Conventional and kilohertz-frequency spinal cord stimulation produces intensity- and frequency-dependent inhibition of mechanical hypersensitivity in a rat model of neuropathic pain. Anesthesiology. 119: 422-32. PMID 23880991 DOI: 10.1097/ALN.0b013e31829bd9e2  0.96
2013 He SQ, Yang F, Perez FM, Xu Q, Shechter R, Cheong YK, Carteret AF, Dong X, Sweitzer SM, Raja SN, Guan Y. Tolerance develops to the antiallodynic effects of the peripherally acting opioid loperamide hydrochloride in nerve-injured rats. Pain. 154: 2477-86. PMID 23880055 DOI: 10.1016/j.pain.2013.07.023  0.96
2013 Tang Z, Kim A, Masuch T, Park K, Weng H, Wetzel C, Dong X. Pirt functions as an endogenous regulator of TRPM8. Nature Communications. 4: 2179. PMID 23863968 DOI: 10.1038/ncomms3179  1
2013 Zhao X, Tang Z, Zhang H, Atianjoh FE, Zhao JY, Liang L, Wang W, Guan X, Kao SC, Tiwari V, Gao YJ, Hoffman PN, Cui H, Li M, Dong X, et al. A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons. Nature Neuroscience. 16: 1024-31. PMID 23792947 DOI: 10.1038/nn.3438  0.96
2013 Han L, Ma C, Liu Q, Weng HJ, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li Z, McNeil B, He S, Guan Y, Xiao B, ... ... Dong X, et al. A subpopulation of nociceptors specifically linked to itch. Nature Neuroscience. 16: 174-82. PMID 23263443 DOI: 10.1038/nn.3289  0.96
2012 Liu Q, Sikand P, Ma C, Tang Z, Han L, Li Z, Sun S, LaMotte RH, Dong X. Mechanisms of itch evoked by β-alanine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 14532-7. PMID 23077038 DOI: 10.1523/JNEUROSCI.3509-12.2012  0.96
2012 Liu T, Berta T, Xu ZZ, Park CK, Zhang L, Lü N, Liu Q, Liu Y, Gao YJ, Liu YC, Ma Q, Dong X, Ji RR. TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice. The Journal of Clinical Investigation. 122: 2195-207. PMID 22565312 DOI: 10.1172/JCI45414  0.96
2012 Hu JH, Yang L, Kammermeier PJ, Moore CG, Brakeman PR, Tu J, Yu S, Petralia RS, Li Z, Zhang PW, Park JM, Dong X, Xiao B, Worley PF. Preso1 dynamically regulates group I metabotropic glutamate receptors. Nature Neuroscience. 15: 836-44. PMID 22561452 DOI: 10.1038/nn.3103  0.96
2012 McNeil B, Dong X. Peripheral mechanisms of itch. Neuroscience Bulletin. 28: 100-10. PMID 22466121 DOI: 10.1007/s12264-012-1202-1  0.96
2011 Liu Q, Weng HJ, Patel KN, Tang Z, Bai H, Steinhoff M, Dong X. The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia. Science Signaling. 4: ra45. PMID 21775281 DOI: 10.1126/scisignal.2001925  0.96
2011 Patel KN, Dong X. Itch: Cells, Molecules, and Circuits. Acs Chemical Neuroscience. 2: 17-25. PMID 21720568 DOI: 10.1021/cn100085g  0.96
2011 Patel KN, Liu Q, Meeker S, Undem BJ, Dong X. Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch. Plos One. 6: e20559. PMID 21655234 DOI: 10.1371/journal.pone.0020559  0.96
2011 Sikand P, Dong X, LaMotte RH. BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 7563-7. PMID 21593341 DOI: 10.1523/JNEUROSCI.1192-11.2011  0.96
2011 Wilson SR, Gerhold KA, Bifolck-Fisher A, Liu Q, Patel KN, Dong X, Bautista DM. TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch. Nature Neuroscience. 14: 595-602. PMID 21460831 DOI: 10.1038/nn.2789  0.96
2010 Patel KN, Dong X. An itch to be scratched. Neuron. 68: 334-9. PMID 21040839 DOI: 10.1016/j.neuron.2010.10.018  0.96
2010 Guan Y, Liu Q, Tang Z, Raja SN, Anderson DJ, Dong X. Mas-related G-protein-coupled receptors inhibit pathological pain in mice. Proceedings of the National Academy of Sciences of the United States of America. 107: 15933-8. PMID 20724664 DOI: 10.1073/pnas.1011221107  0.96
2009 Liu Q, Tang Z, Surdenikova L, Kim S, Patel KN, Kim A, Ru F, Guan Y, Weng HJ, Geng Y, Undem BJ, Kollarik M, Chen ZF, Anderson DJ, Dong X. Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell. 139: 1353-65. PMID 20004959 DOI: 10.1016/j.cell.2009.11.034  0.96
2008 Kim AY, Tang Z, Liu Q, Patel KN, Maag D, Geng Y, Dong X. Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1. Cell. 133: 475-85. PMID 18455988 DOI: 10.1016/j.cell.2008.02.053  0.96
2008 Lee MG, Dong X, Liu Q, Patel KN, Choi OH, Vonakis B, Undem BJ. Agonists of the MAS-related gene (Mrgs) orphan receptors as novel mediators of mast cell-sensory nerve interactions. Journal of Immunology (Baltimore, Md. : 1950). 180: 2251-5. PMID 18250432  0.96
2008 Liu Y, Yang FC, Okuda T, Dong X, Zylka MJ, Chen CL, Anderson DJ, Kuner R, Ma Q. Mechanisms of compartmentalized expression of Mrg class G-protein-coupled sensory receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 125-32. PMID 18171930 DOI: 10.1523/JNEUROSCI.4472-07.2008  0.96
2007 Liu Q, Vrontou S, Rice FL, Zylka MJ, Dong X, Anderson DJ. Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch. Nature Neuroscience. 10: 946-8. PMID 17618277 DOI: 10.1038/nn1937  0.96
2007 Fiacco TA, Agulhon C, Taves SR, Petravicz J, Casper KB, Dong X, Chen J, McCarthy KD. Selective stimulation of astrocyte calcium in situ does not affect neuronal excitatory synaptic activity. Neuron. 54: 611-26. PMID 17521573 DOI: 10.1016/j.neuron.2007.04.032  0.96
2003 Zylka MJ, Dong X, Southwell AL, Anderson DJ. Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. Proceedings of the National Academy of Sciences of the United States of America. 100: 10043-8. PMID 12909716 DOI: 10.1073/pnas.1732949100  0.96
2002 Han SK, Dong X, Hwang JI, Zylka MJ, Anderson DJ, Simon MI. Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway. Proceedings of the National Academy of Sciences of the United States of America. 99: 14740-5. PMID 12397184 DOI: 10.1073/pnas.192565799  0.96
2001 Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell. 106: 619-32. PMID 11551509 DOI: 10.1016/S0092-8674(01)00483-4  0.96
1998 Jackson GR, Salecker I, Dong X, Yao X, Arnheim N, Faber PW, MacDonald ME, Zipursky SL. Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons. Neuron. 21: 633-42. PMID 9768849 DOI: 10.1016/S0896-6273(00)80573-5  0.96
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