| Year |
Citation |
Score |
| 2022 |
Luo JE, Li YM. Turning the tide on Alzheimer's disease: modulation of γ-secretase. Cell & Bioscience. 12: 2. PMID 34983641 DOI: 10.1186/s13578-021-00738-7 |
0.428 |
|
| 2021 |
Xu P, Chang JC, Zhou X, Wang W, Bamkole M, Wong E, Bettayeb K, Jiang LL, Huang T, Luo W, Xu H, Nairn AC, Flajolet M, Ip NY, Li YM, et al. GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease. The Journal of Experimental Medicine. 218. PMID 34156424 DOI: 10.1084/jem.20202446 |
0.311 |
|
| 2020 |
Mekala S, Nelson G, Li YM. Recent developments of small molecule γ-secretase modulators for Alzheimer's disease. Rsc Medicinal Chemistry. 11: 1003-1022. PMID 33479693 DOI: 10.1039/d0md00196a |
0.402 |
|
| 2020 |
Wong E, Frost GR, Li YM. γ-Secretase Modulatory Proteins: The Guiding Hand Behind the Running Scissors. Frontiers in Aging Neuroscience. 12: 614690. PMID 33343338 DOI: 10.3389/fnagi.2020.614690 |
0.446 |
|
| 2020 |
Sinha A, Chang JC, Xu P, Gindinova K, Cho Y, Sun W, Wu X, Li YM, Greengard P, Kelly JW, Sinha SC. Brain Permeable Tafamidis Amide Analogs for Stabilizing TTR and Reducing APP Cleavage. Acs Medicinal Chemistry Letters. 11: 1973-1979. PMID 33062181 DOI: 10.1021/acsmedchemlett.9b00688 |
0.31 |
|
| 2020 |
Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, ... Li YM, et al. The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease. Nature. PMID 32879487 DOI: 10.1038/S41586-020-2681-2 |
0.496 |
|
| 2020 |
Luo W, Ip FCF, Fu G, Cheung K, Tian Y, Hu Y, Sinha A, Cheng EYL, Wu X, Bustos V, Greengard P, Li YM, Sinha SC, Ip NY. A pentacyclic triterpene from targets γ-secretase. Acs Chemical Neuroscience. PMID 32786303 DOI: 10.1021/Acschemneuro.0C00389 |
0.516 |
|
| 2020 |
Nie P, Vartak A, Li YM. γ-Secretase inhibitors and modulators: Mechanistic insights into the function and regulation of γ-Secretase. Seminars in Cell & Developmental Biology. PMID 32249070 DOI: 10.1016/j.semcdb.2020.03.002 |
0.658 |
|
| 2020 |
Zhao J, Xiao Y, Liu X, Kim S, Wu X, Barros M, Zhuang R, Hou X, Zhang Y, Robakis NK, Li YM, Dordick JS, Ubarretxena-Belandia I, Wang C. Substrate interaction inhibits γ-secretase production of amyloid-β peptides. Chemical Communications (Cambridge, England). PMID 32016207 DOI: 10.1039/C9Cc09170J |
0.32 |
|
| 2019 |
Wong E, Liao GP, Chang JC, Xu P, Li YM, Greengard P. GSAP modulates γ-secretase specificity by inducing conformational change in PS1. Proceedings of the National Academy of Sciences of the United States of America. PMID 30850537 DOI: 10.1073/pnas.1820160116 |
0.372 |
|
| 2019 |
Yusof HH, Lee HC, Seth EA, Wu X, Hewitt CA, Scott HS, Cheah PS, Li YM, Chau DM, Ling KH. Expression Profiling of Notch Signalling Pathway and Gamma-Secretase Activity in the Brain of Ts1Cje Mouse Model of Down Syndrome. Journal of Molecular Neuroscience : Mn. PMID 30758748 DOI: 10.1007/s12031-019-01275-2 |
0.734 |
|
| 2019 |
Zhao J, Xiao Y, Liu X, Kim S, Wu X, Barros M, Zhuang M, Robakis NK, Li Y, Wang C. SUBSTRATE BINDING INHIBITS γ-SECRETASE CLEAVAGE OF AMYLOID PRECURSOR PROTEIN Alzheimers & Dementia. 15: 1595. DOI: 10.1016/J.Jalz.2019.09.052 |
0.454 |
|
| 2017 |
Frost GR, Li YM. The role of astrocytes in amyloid production and Alzheimer's disease. Open Biology. 7. PMID 29237809 DOI: 10.1098/rsob.170228 |
0.333 |
|
| 2017 |
Frost GR, Wong E, Li YM. Versatility of presenilin 1. Proceedings of the National Academy of Sciences of the United States of America. PMID 28645897 DOI: 10.1073/pnas.1707809114 |
0.303 |
|
| 2017 |
Johnson DS, Li YM, Pettersson M, St George-Hyslop PH. Structural and Chemical Biology of Presenilin Complexes. Cold Spring Harbor Perspectives in Medicine. PMID 28320827 DOI: 10.1101/Cshperspect.A024067 |
0.468 |
|
| 2017 |
Gertsik N, Am Ende CW, Geoghegan KF, Nguyen C, Mukherjee P, Mente S, Seneviratne U, Johnson DS, Li YM. Mapping the Binding Site of BMS-708163 on γ-Secretase with Cleavable Photoprobes. Cell Chemical Biology. PMID 28065657 DOI: 10.1016/J.Chembiol.2016.12.006 |
0.461 |
|
| 2016 |
Crump CJ, Murrey HE, Ballard TE, Am Ende CW, Wu X, Gertsik N, Johnson DS, Li YM. Development of Sulfonamide Photoaffinity Inhibitors for Probing Cellular γ-Secretase. Acs Chemical Neuroscience. PMID 27253220 DOI: 10.1021/Acschemneuro.6B00127 |
0.477 |
|
| 2016 |
Carroll CM, Li YM. Physiological and pathological roles of the γ-secretase complex. Brain Research Bulletin. PMID 27133790 DOI: 10.1016/j.brainresbull.2016.04.019 |
0.427 |
|
| 2016 |
Zhang X, Sullivan E, Scimeca M, Wu X, Li YM, Sisodia SS. Evidence that the "Lid" Domain of Nicastrin Is Not Essential for Regulating γ-Secretase Activity. The Journal of Biological Chemistry. PMID 26887941 DOI: 10.1074/Jbc.C115.701649 |
0.457 |
|
| 2015 |
Gilchrist ML, Ahn K, Li YM. Imaging and Functional Analysis of γ-Secretase and Substrate in a Proteolipobead System with an Activity-Based Probe. Analytical Chemistry. PMID 26699370 DOI: 10.1021/Acs.Analchem.5B03762 |
0.379 |
|
| 2015 |
Gertsik N, Chau DM, Li YM. γ-Secretase Inhibitors and Modulators Induce Distinct Conformational Changes in the Active Sites of γ-Secretase and Signal Peptide Peptidase. Acs Chemical Biology. 10: 1925-31. PMID 26030233 DOI: 10.1021/acschembio.5b00321 |
0.777 |
|
| 2015 |
Dang S, Wu S, Wang J, Li H, Huang M, He W, Li YM, Wong CC, Shi Y. Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH. Proceedings of the National Academy of Sciences of the United States of America. 112: 3344-9. PMID 25733893 DOI: 10.1073/Pnas.1502150112 |
0.488 |
|
| 2014 |
Gertsik N, Chiu D, Li YM. Complex regulation of γ-secretase: from obligatory to modulatory subunits. Frontiers in Aging Neuroscience. 6: 342. PMID 25610395 DOI: 10.3389/Fnagi.2014.00342 |
0.554 |
|
| 2014 |
Zhang X, Hoey R, Koide A, Dolios G, Paduch M, Nguyen P, Wu X, Li Y, Wagner SL, Wang R, Koide S, Sisodia SS. A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of γ-secretase. The Journal of Biological Chemistry. 289: 34851-61. PMID 25352592 DOI: 10.1074/Jbc.M114.609636 |
0.511 |
|
| 2014 |
Villa JC, Chiu D, Brandes AH, Escorcia FE, Villa CH, Maguire WF, Hu CJ, de Stanchina E, Simon MC, Sisodia SS, Scheinberg DA, Li YM. Nontranscriptional role of Hif-1α in activation of γ-secretase and notch signaling in breast cancer. Cell Reports. 8: 1077-92. PMID 25131208 DOI: 10.1016/J.Celrep.2014.07.028 |
0.414 |
|
| 2014 |
Gertsik N, Ballard TE, Am Ende CW, Johnson DS, Li YM. Development of CBAP-BPyne, a probe for γ-secretase and presenilinase. Medchemcomm. 5: 338-341. PMID 24914408 DOI: 10.1039/C3Md00281K |
0.498 |
|
| 2014 |
Minuesa G, Antczak C, Shum D, Radu C, Bhinder B, Li Y, Djaballah H, Kharas MG. A 1536-well fluorescence polarization assay to screen for modulators of the MUSASHI family of RNA-binding proteins. Combinatorial Chemistry & High Throughput Screening. 17: 596-609. PMID 24912481 DOI: 10.2174/1386207317666140609122714 |
0.315 |
|
| 2014 |
Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE. Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species. Biochemistry. 53: 702-13. PMID 24401146 DOI: 10.1021/Bi401537V |
0.452 |
|
| 2014 |
Chen W, Gamache E, Rosenman DJ, Xie J, Lopez MM, Li YM, Wang C. Familial Alzheimer's mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site. Nature Communications. 5: 3037. PMID 24390130 DOI: 10.1038/Ncomms4037 |
0.339 |
|
| 2013 |
Crump CJ, Johnson DS, Li YM. Development and mechanism of γ-secretase modulators for Alzheimer's disease. Biochemistry. 52: 3197-216. PMID 23614767 DOI: 10.1021/Bi400377P |
0.56 |
|
| 2013 |
Chau DM, Shum D, Radu C, Bhinder B, Gin D, Gilchrist ML, Djaballah H, Li YM. A novel high throughput 1536-well notch1 γsecretase AlphaLISA assay Combinatorial Chemistry and High Throughput Screening. 16: 415-424. PMID 23448293 DOI: 10.2174/1386207311316060001 |
0.755 |
|
| 2013 |
Pozdnyakov N, Murrey HE, Crump CJ, Pettersson M, Ballard TE, Am Ende CW, Ahn K, Li YM, Bales KR, Johnson DS. γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin. The Journal of Biological Chemistry. 288: 9710-20. PMID 23396974 DOI: 10.1074/Jbc.M112.398602 |
0.491 |
|
| 2013 |
Li Y. Endogenous and exogenous regulation of gamma-secretase Molecular Neurodegeneration. 8: 1-1. DOI: 10.1186/1750-1326-8-S1-O10 |
0.552 |
|
| 2012 |
Crump CJ, Castro SV, Wang F, Pozdnyakov N, Ballard TE, Sisodia SS, Bales KR, Johnson DS, Li YM. BMS-708,163 targets presenilin and lacks notch-sparing activity. Biochemistry. 51: 7209-11. PMID 22931393 DOI: 10.1021/Bi301137H |
0.431 |
|
| 2012 |
Zhang X, Hoey RJ, Lin G, Koide A, Leung B, Ahn K, Dolios G, Paduch M, Ikeuchi T, Wang R, Li YM, Koide S, Sisodia SS. Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies. Proceedings of the National Academy of Sciences of the United States of America. 109: 8534-9. PMID 22586122 DOI: 10.1073/Pnas.1202691109 |
0.401 |
|
| 2012 |
Chau DM, Crump CJ, Villa JC, Scheinberg DA, Li YM. Familial Alzheimer disease presenilin-1 mutations alter the active site conformation of γ-secretase. The Journal of Biological Chemistry. 287: 17288-96. PMID 22461631 DOI: 10.1074/Jbc.M111.300483 |
0.777 |
|
| 2012 |
Crump CJ, am Ende CW, Ballard TE, Pozdnyakov N, Pettersson M, Chau DM, Bales KR, Li YM, Johnson DS. Development of clickable active site-directed photoaffinity probes for γ-secretase. Bioorganic & Medicinal Chemistry Letters. 22: 2997-3000. PMID 22418280 DOI: 10.1016/J.Bmcl.2012.02.027 |
0.752 |
|
| 2012 |
Li Y. Gamma-secretase: from pathogenesis to therapeutics. Molecular Neurodegeneration. 7: 1-1. DOI: 10.1186/1750-1326-7-S1-L4 |
0.469 |
|
| 2011 |
Crump CJ, Fish BA, Castro SV, Chau DM, Gertsik N, Ahn K, Stiff C, Pozdnyakov N, Bales KR, Johnson DS, Li YM. Piperidine acetic acid based γ-secretase modulators directly bind to Presenilin-1. Acs Chemical Neuroscience. 2: 705-710. PMID 22229075 DOI: 10.1021/Cn200098P |
0.793 |
|
| 2011 |
Li T, Li YM, Ahn K, Price DL, Sisodia SS, Wong PC. Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo. Plos One. 6: e28179. PMID 22140537 DOI: 10.1371/Journal.Pone.0028179 |
0.396 |
|
| 2011 |
Crump CJ, Johnson DS, Li YM. Target of γ-secretase modulators, presenilin marks the spot. The Embo Journal. 30: 4696-8. PMID 22126818 DOI: 10.1038/Emboj.2011.410 |
0.49 |
|
| 2011 |
Antczak C, Shum D, Bassit B, Frattini MG, Li Y, de Stanchina E, Scheinberg DA, Djaballah H. Identification of benzofuran-4,5-diones as novel and selective non-hydroxamic acid, non-peptidomimetic based inhibitors of human peptide deformylase. Bioorganic & Medicinal Chemistry Letters. 21: 4528-32. PMID 21719286 DOI: 10.1016/J.Bmcl.2011.05.129 |
0.337 |
|
| 2011 |
Renzi F, Zhang X, Rice WJ, Torres-Arancivia C, Gomez-Llorente Y, Diaz R, Ahn K, Yu C, Li YM, Sisodia SS, Ubarretxena-Belandia I. Structure of gamma-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy. The Journal of Biological Chemistry. 286: 21440-9. PMID 21454611 DOI: 10.1074/Jbc.M110.193326 |
0.462 |
|
| 2010 |
Ahn K, Shelton CC, Tian Y, Zhang X, Gilchrist ML, Sisodia SS, Li YM. Activation and intrinsic gamma-secretase activity of presenilin 1. Proceedings of the National Academy of Sciences of the United States of America. 107: 21435-40. PMID 21115843 DOI: 10.1073/Pnas.1013246107 |
0.511 |
|
| 2010 |
Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, ... Li YM, et al. Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron. 67: 769-80. PMID 20826309 DOI: 10.1016/J.Neuron.2010.08.018 |
0.518 |
|
| 2010 |
Tian Y, Crump CJ, Li YM. Dual role of alpha-secretase cleavage in the regulation of gamma-secretase activity for amyloid production. The Journal of Biological Chemistry. 285: 32549-56. PMID 20675367 DOI: 10.1074/Jbc.M110.128439 |
0.482 |
|
| 2010 |
Yang T, Arslanova D, Xu X, Li YM, Xia W. In vivo manifestation of Notch related phenotypes in zebrafish treated with Alzheimer's amyloid reducing gamma-secretase inhibitors. Journal of Neurochemistry. 113: 1200-9. PMID 20345767 DOI: 10.1111/j.1471-4159.2010.06681.x |
0.369 |
|
| 2010 |
Placanica L, Chien JW, Li YM. Characterization of an atypical gamma-secretase complex from hematopoietic origin. Biochemistry. 49: 2796-804. PMID 20178366 DOI: 10.1021/Bi901388T |
0.775 |
|
| 2010 |
Tian Y, Bassit B, Chau D, Li YM. An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production. Nature Structural & Molecular Biology. 17: 151-8. PMID 20062056 DOI: 10.1038/nsmb.1743 |
0.493 |
|
| 2009 |
Shelton CC, Zhu L, Chau D, Yang L, Wang R, Djaballah H, Zheng H, Li YM. Modulation of gamma-secretase specificity using small molecule allosteric inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 106: 20228-33. PMID 19906985 DOI: 10.1073/Pnas.0910757106 |
0.797 |
|
| 2009 |
Shelton CC, Tian Y, Shum D, Radu C, Djaballah H, Li YM. A miniaturized 1536-well format gamma-secretase assay. Assay and Drug Development Technologies. 7: 461-70. PMID 19715456 DOI: 10.1089/Adt.2009.0202 |
0.503 |
|
| 2009 |
Shelton CC, Tian Y, Frattini MG, Li YM. An exo-cell assay for examining real-time gamma-secretase activity and inhibition. Molecular Neurodegeneration. 4: 22. PMID 19490610 DOI: 10.1186/1750-1326-4-22 |
0.387 |
|
| 2009 |
Placanica L, Zhu L, Li YM. Gender- and age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease. Plos One. 4: e5088. PMID 19352431 DOI: 10.1371/journal.pone.0005088 |
0.757 |
|
| 2009 |
Escobar-Alvarez S, Goldgur Y, Yang G, Ouerfelli O, Li Y, Scheinberg DA. Structure and activity of human mitochondrial peptide deformylase, a novel cancer target. Journal of Molecular Biology. 387: 1211-28. PMID 19236878 DOI: 10.1016/J.Jmb.2009.02.032 |
0.375 |
|
| 2009 |
Placanica L, Tarassishin L, Yang G, Peethumnongsin E, Kim SH, Zheng H, Sisodia SS, Li YM. Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes. The Journal of Biological Chemistry. 284: 2967-77. PMID 19036728 DOI: 10.1074/Jbc.M807269200 |
0.778 |
|
| 2008 |
Lei X, Ahn K, Zhu L, Ubarretxena-Belandia I, Li YM. Soluble oligomers of the intramembrane serine protease YqgP are catalytically active in the absence of detergents. Biochemistry. 47: 11920-9. PMID 18937501 DOI: 10.1021/Bi800385R |
0.401 |
|
| 2008 |
Vetrivel KS, Zhang X, Meckler X, Cheng H, Lee S, Gong P, Lopes KO, Chen Y, Iwata N, Yin KJ, Lee JM, Parent AT, Saido TC, Li YM, Sisodia SS, et al. Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta. The Journal of Biological Chemistry. 283: 19489-98. PMID 18456655 DOI: 10.1074/Jbc.M801037200 |
0.433 |
|
| 2007 |
Yin YI, Bassit B, Zhu L, Yang X, Wang C, Li YM. {gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE. The Journal of Biological Chemistry. 282: 23639-44. PMID 17556361 DOI: 10.1074/Jbc.M704601200 |
0.52 |
|
| 2007 |
Xiong K, Clough RW, Luo XG, Struble RG, Li YM, Yan XX. [3H]-L-685,458 as a radiotracer that maps gamma-secretase complex in the rat brain: relevance to Abeta genesis and presence of active presenilin-1 components. Brain Research. 1157: 81-91. PMID 17512915 DOI: 10.1016/j.brainres.2007.04.068 |
0.33 |
|
| 2007 |
Antczak C, Shum D, Escobar S, Bassit B, Kim E, Seshan VE, Wu N, Yang G, Ouerfelli O, Li YM, Scheinberg DA, Djaballah H. High-throughput identification of inhibitors of human mitochondrial peptide deformylase. Journal of Biomolecular Screening. 12: 521-35. PMID 17435169 DOI: 10.1177/1087057107300463 |
0.328 |
|
| 2007 |
Vetrivel KS, Gong P, Bowen JW, Cheng H, Chen Y, Carter M, Nguyen PD, Placanica L, Wieland FT, Li YM, Kounnas MZ, Thinakaran G. Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism. Molecular Neurodegeneration. 2: 4. PMID 17288597 DOI: 10.1186/1750-1326-2-4 |
0.764 |
|
| 2006 |
Deng Y, Tarassishin L, Kallhoff V, Peethumnongsin E, Wu L, Li YM, Zheng H. Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 3845-54. PMID 16597739 DOI: 10.1523/Jneurosci.5384-05.2006 |
0.546 |
|
| 2006 |
Lai MT, Crouthamel MC, DiMuzio J, Pietrak BL, Donoviel DB, Bernstein A, Gardell SJ, Li YM, Hazuda D. A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage. Journal of Neurochemistry. 96: 118-25. PMID 16300640 DOI: 10.1111/J.1471-4159.2005.03528.X |
0.462 |
|
| 2004 |
Tarassishin L, Yin YI, Bassit B, Li YM. Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct. Proceedings of the National Academy of Sciences of the United States of America. 101: 17050-5. PMID 15563588 DOI: 10.1073/Pnas.0408007101 |
0.539 |
|
| 2004 |
Kim SH, Yin YI, Li YM, Sisodia SS. Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway. The Journal of Biological Chemistry. 279: 48615-9. PMID 15456788 DOI: 10.1074/Jbc.C400396200 |
0.509 |
|
| 2004 |
Wang H, Luo WJ, Zhang YW, Li YM, Thinakaran G, Greengard P, Xu H. Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components. The Journal of Biological Chemistry. 279: 40560-6. PMID 15247291 DOI: 10.1074/Jbc.M404345200 |
0.515 |
|
| 2004 |
Li Y, Tarassishin L, Yin Y, Bassit B. O2-03-06 Mechanism of gamma-secretase mediated APP and notch processing Neurobiology of Aging. 25: S37-S38. DOI: 10.1016/S0197-4580(04)80124-6 |
0.351 |
|
| 2003 |
Lee MD, Antczak C, Li Y, Sirotnak FM, Bornmann WG, Scheinberg DA. A new human peptide deformylase inhibitable by actinonin. Biochemical and Biophysical Research Communications. 312: 309-15. PMID 14637138 DOI: 10.1016/J.Bbrc.2003.10.123 |
0.352 |
|
| 2003 |
Schroeter EH, Ilagan MX, Brunkan AL, Hecimovic S, Li YM, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Goate A, Wolfe MS, et al. A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proceedings of the National Academy of Sciences of the United States of America. 100: 13075-80. PMID 14566063 DOI: 10.1073/Pnas.1735338100 |
0.532 |
|
| 2003 |
Netzer WJ, Dou F, Cai D, Veach D, Jean S, Li Y, Bornmann WG, Clarkson B, Xu H, Greengard P. Gleevec inhibits beta-amyloid production but not Notch cleavage. Proceedings of the National Academy of Sciences of the United States of America. 100: 12444-9. PMID 14523244 DOI: 10.1073/Pnas.1534745100 |
0.506 |
|
| 2003 |
Beher D, Fricker M, Nadin A, Clarke EE, Wrigley JD, Li YM, Culvenor JG, Masters CL, Harrison T, Shearman MS. In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand. Biochemistry. 42: 8133-42. PMID 12846562 DOI: 10.1021/Bi034045Z |
0.461 |
|
| 2003 |
Lai MT, Chen E, Crouthamel MC, DiMuzio-Mower J, Xu M, Huang Q, Price E, Register RB, Shi XP, Donoviel DB, Bernstein A, Hazuda D, Gardell SJ, Li YM. Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities. The Journal of Biological Chemistry. 278: 22475-81. PMID 12684521 DOI: 10.1074/Jbc.M300974200 |
0.407 |
|
| 2002 |
Xu M, Lai MT, Huang Q, DiMuzio-Mower J, Castro JL, Harrison T, Nadin A, Neduvelil JG, Shearman MS, Shafer JA, Gardell SJ, Li YM. gamma-Secretase: characterization and implication for Alzheimer disease therapy. Neurobiology of Aging. 23: 1023-30. PMID 12470798 |
0.525 |
|
| 2002 |
Figueroa DJ, Morris JA, Ma L, Kandpal G, Chen E, Li YM, Austin CP. Presenilin-dependent gamma-secretase activity modulates neurite outgrowth. Neurobiology of Disease. 9: 49-60. PMID 11848684 DOI: 10.1006/nbdi.2001.0447 |
0.442 |
|
| 2000 |
Beher D, Li Y, Gardell SJ, Shearman MS. Direct analysis of γ-secretase activity in SH-SY5Y neuroblastoma cells identifies the Golgi as the main compartment of amyloid-β(X-40) peptide. Generation Neurobiology of Aging. 21: 187. DOI: 10.1016/S0197-4580(00)82183-1 |
0.379 |
|
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