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Alison M. Goate, PhD - Publications

Affiliations: 
Genetics Washington University, Saint Louis, St. Louis, MO 
Area:
http://www.researchprofiles.collexis.com/jad/expert.asp?u_id=72
Website:
http://dbbs.wustl.edu/rib/goateAli

500 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Hernández D, Morgan Schlicht S, Daniszewski M, Karch CM, Goate AM, Pébay A. Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the London mutation in APP (V717I). Stem Cell Research. 53: 102373. PMID 34088002 DOI: 10.1016/j.scr.2021.102373  0.8
2021 Caballero B, Bourdenx M, Luengo E, Diaz A, Sohn PD, Chen X, Wang C, Juste YR, Wegmann S, Patel B, Young ZT, Kuo SY, Rodriguez-Navarro JA, Shao H, Lopez MG, ... ... Goate AM, et al. Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice. Nature Communications. 12: 2238. PMID 33854069 DOI: 10.1038/s41467-021-22501-9  0.8
2021 Novikova G, Kapoor M, Tcw J, Abud EM, Efthymiou AG, Chen SX, Cheng H, Fullard JF, Bendl J, Liu Y, Roussos P, Björkegren JL, Liu Y, Poon WW, Hao K, ... ... Goate AM, et al. Integration of Alzheimer's disease genetics and myeloid genomics identifies disease risk regulatory elements and genes. Nature Communications. 12: 1610. PMID 33712570 DOI: 10.1038/s41467-021-21823-y  0.36
2020 Kunkle BW, Schmidt M, Klein HU, Naj AC, Hamilton-Nelson KL, Larson EB, Evans DA, De Jager PL, Crane PK, Buxbaum JD, Ertekin-Taner N, Barnes LL, Fallin MD, Manly JJ, Go RCP, ... ... Goate AM, et al. Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis. Jama Neurology. PMID 33074286 DOI: 10.1001/jamaneurol.2020.3536  0.36
2020 Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, ... ... Goate A, et al. The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease. Nature. PMID 32879487 DOI: 10.1038/S41586-020-2681-2  0.36
2020 Cao J, Huang M, Guo L, Zhu L, Hou J, Zhang L, Pero A, Ng S, El Gaamouch F, Elder G, Sano M, Goate A, Tcw J, Haroutunian V, Zhang B, et al. MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer's disease pathogenesis. Molecular Psychiatry. PMID 32632205 DOI: 10.1038/S41380-020-0824-3  0.36
2020 Aschenbrenner AJ, Petros J, McDade E, Wang G, Balota DA, Benzinger TL, Cruchaga C, Goate A, Xiong C, Perrin R, Fagan AM, Graff-Radford N, Ghetti B, Levin J, Weidinger E, et al. Relationships between big-five personality factors and Alzheimer's disease pathology in autosomal dominant Alzheimer's disease. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12038. PMID 32587883 DOI: 10.1002/Dad2.12038  0.8
2020 Neuner SM, Tcw J, Goate AM. Genetic architecture of Alzheimer's disease. Neurobiology of Disease. 104976. PMID 32565066 DOI: 10.1016/J.Nbd.2020.104976  0.36
2020 Schultz SA, Strain JF, Adedokun A, Wang Q, Preische O, Kuhle J, Flores S, Keefe S, Dincer A, Ances BM, Berman SB, Brickman AM, Cash DM, Chhatwal J, Cruchaga C, ... ... Goate A, et al. Serum neurofilament light chain levels are associated with white matter integrity in autosomal dominant Alzheimer's disease. Neurobiology of Disease. 104960. PMID 32522711 DOI: 10.1016/J.Nbd.2020.104960  0.8
2020 Gregory JA, Hoelzli E, Abdelaal R, Braine C, Cuevas M, Halpern M, Barretto N, Schrode N, Akbalik G, Kang K, Cheng E, Bowles K, Lotz S, Goderie S, Karch CM, ... ... Goate A, et al. Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models. Cells. 9. PMID 32516938 DOI: 10.3390/Cells9061406  0.8
2020 Barthélemy NR, Li Y, Joseph-Mathurin N, Gordon BA, Hassenstab J, Benzinger TLS, Buckles V, Fagan AM, Perrin RJ, Goate AM, Morris JC, Karch CM, Xiong C, Allegri R, Mendez PC, et al. A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease. Nature Medicine. 26: 398-407. PMID 32161412 DOI: 10.1038/S41591-020-0781-Z  0.8
2020 Hsu S, Pimenova AA, Hayes K, Villa JA, Rosene MJ, Jere M, Goate AM, Karch CM. Systematic validation of variants of unknown significance in APP, PSEN1 and PSEN2. Neurobiology of Disease. 104817. PMID 32087291 DOI: 10.1016/J.Nbd.2020.104817  0.8
2020 Franzmeier N, Koutsouleris N, Benzinger T, Goate A, Karch CM, Fagan AM, McDade E, Duering M, Dichgans M, Levin J, Gordon BA, Lim YY, Masters CL, Rossor M, Fox NC, et al. Predicting sporadic Alzheimer's disease progression via inherited Alzheimer's disease-informed machine-learning. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32043733 DOI: 10.1002/Alz.12032  0.8
2020 Pimenova AA, Goate AM. Novel presenilin 1 and 2 double knock-out cell line for in vitro validation of PSEN1 and PSEN2 mutations. Neurobiology of Disease. 138: 104785. PMID 32032730 DOI: 10.1016/J.Nbd.2020.104785  0.32
2020 Aschenbrenner AJ, James BD, McDade E, Wang G, Lim YY, Benzinger TLS, Cruchaga C, Goate A, Xiong C, Perrin R, Buckles V, Allegri R, Berman SB, Chhatwal JP, Fagan A, et al. Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN). Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 16: 219-228. PMID 31914221 DOI: 10.1002/Alz.12010  0.8
2019 Bis JC, Jian X, Kunkle BW, Chen Y, Hamilton-Nelson KL, Bush WS, Salerno WJ, Lancour D, Ma Y, Renton AE, Marcora E, Farrell JJ, Zhao Y, Qu L, Ahmad S, ... ... Goate A, et al. Correction: Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. Molecular Psychiatry. PMID 31636380 DOI: 10.1038/s41380-019-0529-7  0.8
2019 Karch CM, Kao AW, Karydas A, Onanuga K, Martinez R, Argouarch A, Wang C, Huang C, Sohn PD, Bowles KR, Spina S, Silva MC, Marsh JA, Hsu S, Pugh DA, ... ... Goate AM, et al. A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies. Stem Cell Reports. PMID 31631020 DOI: 10.1016/J.Stemcr.2019.09.006  0.8
2019 Dumitrescu L, Barnes LL, Thambisetty M, Beecham G, Kunkle B, Bush WS, Gifford KA, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Crane PK, Resnick SM, Keene CD, Montine TJ, ... ... Goate AM, et al. Sex differences in the genetic predictors of Alzheimer's pathology. Brain : a Journal of Neurology. 142: 2581-2589. PMID 31497858 DOI: 10.1093/Brain/Awz206  0.8
2019 Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Goate AM, et al. Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. PMID 31417202 DOI: 10.1038/s41588-019-0495-7  0.68
2019 Baker E, Sims R, Leonenko G, Frizzati A, Harwood JC, Grozeva D, Morgan K, Passmore P, Holmes C, Powell J, ... ... Goate AM, et al. Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer's disease. Plos One. 14: e0218111. PMID 31283791 DOI: 10.1371/Journal.Pone.0218111  0.8
2019 Hernandez I, Luna G, Rauch JN, Reis SA, Giroux M, Karch CM, Boctor D, Sibih YE, Storm NJ, Diaz A, Kaushik S, Zekanowski C, Kang AA, Hinman CR, Cerovac V, ... ... Goate AM, et al. A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy. Science Translational Medicine. 11. PMID 30918111 DOI: 10.1126/Scitranslmed.Aat3005  0.8
2019 Franzmeier N, Ren J, Damm A, Monté-Rubio G, Boada M, Ruiz A, Ramirez A, Jessen F, Düzel E, Rodríguez Gómez O, Benzinger T, Goate A, Karch CM, Fagan AM, McDade E, et al. The BDNF SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease. Molecular Psychiatry. PMID 30899092 DOI: 10.1038/S41380-019-0404-6  0.8
2019 Vöglein J, Paumier K, Jucker M, Preische O, McDade E, Hassenstab J, Benzinger TL, Noble JM, Berman SB, Graff-Radford NR, Ghetti B, Farlow MR, Chhatwal J, Salloway S, Xiong C, ... ... Goate A, et al. Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease. Brain : a Journal of Neurology. PMID 30897203 DOI: 10.1093/Brain/Awz050  0.8
2019 Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Goate AM, et al. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. 51: 414-430. PMID 30820047 DOI: 10.1038/s41588-019-0358-2  0.96
2019 Kapoor M, Wang JC, Farris SP, Liu Y, McClintick J, Gupta I, Meyers JL, Bertelsen S, Chao M, Nurnberger J, Tischfield J, Harari O, Zeran L, Hesselbrock V, Bauer L, ... ... Goate A, et al. Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism. Translational Psychiatry. 9: 89. PMID 30765688 DOI: 10.1038/S41398-019-0384-Y  0.44
2019 Preische O, Schultz SA, Apel A, Kuhle J, Kaeser SA, Barro C, Gräber S, Kuder-Buletta E, LaFougere C, Laske C, Vöglein J, Levin J, Masters CL, Martins R, Schofield PR, ... ... Goate AM, et al. Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease. Nature Medicine. PMID 30664784 DOI: 10.1038/S41591-018-0304-3  0.44
2019 Jaworski J, Kunkle BW, Rajabli F, Adams LD, Starks TD, Goate AM, Cuccaro ML, Vance JM, Martin ER, Foroud TM, Mayeux R, Reitz C, Byrd GS, Beecham GW, Pericak-Vance MA. O3-13-02: Genome-Wide Linkage Analysis Of African-American Alzheimer Disease Families Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.4697  0.36
2019 Fernandez V, Huey D, Budde JP, Farias FHG, Harari O, Norton J, Gentsch J, Morris JC, Goate A, Rademakers R, Graff-Radford NR, Boeve BF, Kauwe J, Cruchaga C, Nia-Load. O2-10-02: Whole Exome Sequencing Analysis In Early Onset Alzheimer Reveals Novel Candidate Genes Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.4506  0.8
2019 Meyers J, Zhang J, Chorlian D, Pandey A, Wang J, Wetherill L, Lai D, Chao M, Kapoor M, Salvatore J, Agrawal A, Edenberg H, Foround T, Goate A, Porjesz B. M97. A Genome Wide Association Study Of Interhemispheric Theta Eeg Coherence: Implications For Neural Connectivity And Alcohol Use Behavior European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2019.08.197  0.64
2018 Joseph-Mathurin N, Su Y, Blazey TM, Jasielec M, Vlassenko A, Friedrichsen K, Gordon BA, Hornbeck RC, Cash L, Ances BM, Veale T, Cash DM, Brickman AM, Buckles V, Cairns NJ, ... ... Goate A, et al. Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease. Alzheimer's & Dementia (Amsterdam, Netherlands). 10: 669-677. PMID 30417072 DOI: 10.1016/J.Dadm.2018.08.012  0.8
2018 Rathore N, Ramani SR, Pantua H, Payandeh J, Bhangale T, Wuster A, Kapoor M, Sun Y, Kapadia SB, Gonzalez L, Zarrin AA, Goate A, Hansen DV, Behrens TW, Graham RR. Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease. Plos Genetics. 14: e1007427. PMID 30388101 DOI: 10.1371/Journal.Pgen.1007427  0.32
2018 Araque Caballero MÁ, Suárez-Calvet M, Duering M, Franzmeier N, Benzinger T, Fagan AM, Bateman RJ, Jack CR, Levin J, Dichgans M, Jucker M, Karch C, Masters CL, Morris JC, Weiner M, ... ... Goate A, et al. White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease. Brain : a Journal of Neurology. PMID 30239611 DOI: 10.1093/Brain/Awy229  0.64
2018 McDade E, Wang G, Gordon BA, Hassenstab J, Benzinger TLS, Buckles V, Fagan AM, Holtzman DM, Cairns NJ, Goate AM, Marcus DS, Morris JC, Paumier K, Xiong C, Allegri R, et al. Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease. Neurology. PMID 30217935 DOI: 10.1212/Wnl.0000000000006277  0.44
2018 Maxwell TJ, Corcoran C, Del-Aguila JL, Budde JP, Deming Y, Cruchaga C, Goate AM, Kauwe JSK. Genome-wide association study for variants that modulate relationships between cerebrospinal fluid amyloid-beta 42, tau, and p-tau levels. Alzheimer's Research & Therapy. 10: 86. PMID 30153862 DOI: 10.1186/S13195-018-0410-Y  0.8
2018 Bis JC, Jian X, Kunkle BW, Chen Y, Hamilton-Nelson KL, Bush WS, Salerno WJ, Lancour D, Ma Y, Renton AE, Marcora E, Farrell JJ, Zhao Y, Qu L, Ahmad S, ... ... Goate A, et al. Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. Molecular Psychiatry. PMID 30108311 DOI: 10.1038/S41380-018-0112-7  0.8
2018 Karch CM, Hernández D, Wang JC, Marsh J, Hewitt AW, Hsu S, Norton J, Levitch D, Donahue T, Sigurdson W, Ghetti B, Farlow M, Chhatwal J, Berman S, Cruchaga C, ... ... Goate AM, et al. Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network. Alzheimer's Research & Therapy. 10: 69. PMID 30045758 DOI: 10.1186/S13195-018-0400-0  0.8
2018 Hsu S, Gordon BA, Hornbeck R, Norton JB, Levitch D, Louden A, Ziegemeier E, Laforce R, Chhatwal J, Day GS, McDade E, Morris JC, Fagan AM, Benzinger TLS, Goate AM, et al. Discovery and validation of autosomal dominant Alzheimer's disease mutations. Alzheimer's Research & Therapy. 10: 67. PMID 30021643 DOI: 10.1186/S13195-018-0392-9  0.8
2018 Lim YY, Hassenstab J, Goate A, Fagan AM, Benzinger TLS, Cruchaga C, McDade E, Chhatwal J, Levin J, Farlow MR, Graff-Radford NR, Laske C, Masters CL, Salloway S, Schofield P, et al. Effect of BDNFVal66Met on disease markers in dominantly inherited AD. Annals of Neurology. PMID 30014553 DOI: 10.1002/Ana.25299  0.8
2018 Deming Y, Dumitrescu L, Barnes LL, Thambisetty M, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Huentelman M, Crane PK, Resnick SM, Keene CD, ... ... Goate AM, et al. Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathologica. PMID 29967939 DOI: 10.1007/s00401-018-1881-4  0.8
2018 Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, ... ... Goate AM, et al. Analysis of shared heritability in common disorders of the brain. Science (New York, N.Y.). 360. PMID 29930110 DOI: 10.1126/Science.Aap8757  0.6
2018 Fernández MV, Budde J, Del-Aguila JL, Ibañez L, Deming Y, Harari O, Norton J, Morris JC, Goate AM, Cruchaga C. Evaluation of Gene-Based Family-Based Methods to Detect Novel Genes Associated With Familial Late Onset Alzheimer Disease. Frontiers in Neuroscience. 12: 209. PMID 29670507 DOI: 10.3389/fnins.2018.00209  0.8
2018 Sassi C, Nalls MA, Ridge PG, Gibbs JR, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Lord J, Turton J, Bras J, Blumenau S, ... ... Goate AM, et al. Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. Neurobiology of Aging. PMID 29544907 DOI: 10.1016/j.neurobiolaging.2018.01.015  0.8
2018 Blue EE, Bis JC, Dorschner MO, Tsuang DW, Barral SM, Beecham G, Below JE, Bush WS, Butkiewicz M, Cruchaga C, DeStefano A, Farrer LA, Goate A, Haines J, Jaworski J, et al. Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project. Dementia and Geriatric Cognitive Disorders. 45: 1-17. PMID 29486463 DOI: 10.1159/000485503  0.8
2018 Del-Aguila JL, Fernández MV, Schindler S, Ibanez L, Deming Y, Ma S, Saef B, Black K, Budde J, Norton J, Chasse R, Harari O, Goate A, Xiong C, et al. Assessment of the Genetic Architecture of Alzheimer's Disease Risk in Rate of Memory Decline. Journal of Alzheimer's Disease : Jad. 62: 745-756. PMID 29480181 DOI: 10.3233/Jad-170834  0.8
2018 Franzmeier N, Düzel E, Jessen F, Buerger K, Levin J, Duering M, Dichgans M, Haass C, Suárez-Calvet M, Fagan AM, Paumier K, Benzinger T, Masters CL, Morris JC, Perneczky R, ... ... Goate A, et al. Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease. Brain : a Journal of Neurology. PMID 29462334 DOI: 10.1093/Brain/Awy008  0.64
2018 Ridge PG, Karch CM, Hsu S, Arano I, Teerlink CC, Ebbert MTW, Murcia JDG, Farnham JM, Damato AR, Allen M, Wang X, Harari O, Fernandez VM, Guerreiro R, Bras J, ... ... Goate AM, et al. Correction to: Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome Medicine. 10: 4. PMID 29329552 DOI: 10.1186/S13073-018-0516-7  0.8
2018 Fernandez MV, Budde JP, Del-Aguila JL, Ibanez L, Deming Y, Harari O, Li Z, Dube U, Norton J, Morris JC, Goate AM, Cruchaga C, Nia-Load, Ncrad. P2-105: Nomination Of Novel Candidate Genes For Familial Late Onset Alzheimer Disease After Evaluation Of Gene-Based Family-Based Methods Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.791  0.8
2018 Mahali S, Hsu S, Benitez B, Martinez R, Goate AM, Karch C, Dian. O2-12-01: Lysosomal Dysfunction And Altered Tau Metabolism In Stem Cell Models Of Autosomal Dominant Alzheimer'S Disease Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.2706  0.36
2018 McDade E, Li Y, Wang G, Gordon BA, Hassenstab J, Benzinger TLS, Fagan AM, Goate AM, Morris JC, Cash DM, Fox NC, Xiong C, Holtzman DM, Bateman RJ. O2-04-03: What Goes Up Must Come Down: Longitudinal Decline In Cerebrospinal Fluid Tau Peptides Is Associated With Progressive Cortical Atrophy Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.2659  0.44
2018 Hassenstab J, Aschenbrenner AJ, Balota DA, McDade E, Lim Y, Fagan AM, Benzinger TLS, Cruchaga C, Goate A, Morris JC, Bateman RJ. O1-04-03: Comparing Smartphone-Administered Cognitive Assessments With Conventional Tests And Biomarkers In Sporadic And Dominantly Inherited Alzheimer Disease Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.2350  0.8
2018 Vardarajan BN, Barral S, Jaworski J, Beecham GW, Blue E, Tosto G, Reyes-Dumeyer D, Medrano M, Lantigua R, Naj AC, Thornton TA, Destefano AL, Martin ER, Wang L, Brown L, ... ... Goate AM, et al. P1-156: Gene-Based Analyses In Whole Genome Sequencing Of Familial Late-Onset Alzheimer'S Disease Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.160  0.36
2018 Kunkle BW, Jaworski J, Rajabli F, Adams LD, Cuccaro ML, Vance JM, Goate AM, Martin ER, Foroud TM, Reitz C, Beecham GW, Mayeux R, Pericak-Vance MA. P1-154: Genome-Wide Linkage Analyses Of African American Families Supports Evidence Of Linkage To Chromosome 12 Alzheimers & Dementia. 14: 336. DOI: 10.1016/J.Jalz.2018.06.158  0.36
2018 Dumitrescu L, Deming Y, Lu Q, Beecham GW, Kunkle BW, Del-Aguila JL, Fernandez MV, Budde JP, Fagan AM, Jager PLD, Albert MS, Moghekar A, Riemenschneider M, Petersen RC, Barnes LL, ... ... Goate AM, et al. P1-139: The Contribution Of Sex-Specific Associations In Genetic Studies Of Alzheimer'S Disease Pathology Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.142  0.8
2018 Barthélemy NR, Li Y, Wang G, Fagan AM, Morris JC, Benzinger TLS, Goate A, Hassenstab J, Xiong C, Sato C, Bateman RJ, McDade E. P1-023: Mass Spectrometry-Based Measurement Of Longitudinal Csf Tau Identifies Different Phosphorylated Sites That Track Distinct Stages Of Presymptomatic Dominantly Inherited Ad Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.024  0.64
2017 Beecham GW, Bis JC, Martin ER, Choi SH, DeStefano AL, van Duijn CM, Fornage M, Gabriel SB, Koboldt DC, Larson DE, Naj AC, Psaty BM, Salerno W, Bush WS, Foroud TM, ... ... Goate A, et al. The Alzheimer's Disease Sequencing Project: Study design and sample selection. Neurology. Genetics. 3: e194. PMID 29184913 DOI: 10.1212/Nxg.0000000000000194  0.64
2017 Ridge PG, Karch CM, Hsu S, Arano I, Teerlink CC, Ebbert MTW, Gonzalez Murcia JD, Farnham JM, Damato AR, Allen M, Wang X, Harari O, Fernandez VM, Guerreiro R, Bras J, ... ... Goate AM, et al. Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome Medicine. 9: 100. PMID 29183403 DOI: 10.1186/S13073-017-0486-1  0.8
2017 Fernández MV, Kim JH, Budde JP, Black K, Medvedeva A, Saef B, Deming Y, Del-Aguila J, Ibañez L, Dube U, Harari O, Norton J, Chasse R, Morris JC, Goate A, et al. Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease. Plos Genetics. 13: e1007045. PMID 29091718 DOI: 10.1371/Journal.Pgen.1007045  0.8
2017 Cruchaga C, Del-Aguila JL, Saef B, Black K, Fernandez MV, Budde J, Ibanez L, Kapoor M, Tosto G, Mayeux RP, Holtzman DM, Fagan AM, Morris JC, Bateman RJ, Goate AM, et al. Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28943286 DOI: 10.1016/J.Jalz.2017.08.013  0.8
2017 Tcw J, Wang M, Pimenova AA, Bowles KR, Hartley BJ, Lacin E, Machlovi SI, Abdelaal R, Karch CM, Phatnani H, Slesinger PA, Zhang B, Goate AM, Brennand KJ. An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells. Stem Cell Reports. PMID 28757165 DOI: 10.1016/J.Stemcr.2017.06.018  0.8
2017 Kinnunen KM, Cash DM, Poole T, Frost C, Benzinger TLS, Ahsan RL, Leung KK, Cardoso MJ, Modat M, Malone IB, Morris JC, Bateman RJ, Marcus DS, Goate A, Salloway S, et al. Presymptomatic atrophy in autosomal dominant Alzheimer's disease: A serial MRI study. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28738187 DOI: 10.1016/J.Jalz.2017.06.2268  0.64
2017 Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, ... ... Goate AM, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics. PMID 28714976 DOI: 10.1038/Ng.3916  0.96
2017 Huang KL, Marcora E, Pimenova AA, Di Narzo AF, Kapoor M, Jin SC, Harari O, Bertelsen S, Fairfax BP, Czajkowski J, Chouraki V, Grenier-Boley B, Bellenguez C, Deming Y, McKenzie A, ... ... Goate AM, et al. A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease. Nature Neuroscience. PMID 28628103 DOI: 10.1038/Nn.4587  0.8
2017 Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, ... ... Goate AM, et al. Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. Plos Medicine. 14: e1002258. PMID 28323831 DOI: 10.1371/Journal.Pmed.1002258  0.8
2017 Deming Y, Li Z, Kapoor M, Harari O, Del-Aguila JL, Black K, Carrell D, Cai Y, Fernandez MV, Budde J, Ma S, Saef B, Howells B, Huang KL, Bertelsen S, ... ... Goate AM, et al. Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers. Acta Neuropathologica. PMID 28247064 DOI: 10.1007/s00401-017-1685-y  0.8
2017 Day GS, Lim TS, Hassenstab J, Goate AM, Grant EA, Roe CM, Cairns NJ, Morris JC. Differentiating cognitive impairment due to corticobasal degeneration and Alzheimer disease. Neurology. PMID 28235814 DOI: 10.1212/Wnl.0000000000003770  0.36
2017 Tosto G, Bird TD, Tsuang D, Bennett DA, Boeve BF, Cruchaga C, Faber K, Foroud TM, Farlow M, Goate AM, Bertlesen S, Graff-Radford NR, Medrano M, Lantigua R, Manly J, et al. Polygenic risk scores in familial Alzheimer disease. Neurology. PMID 28213371 DOI: 10.1212/Wnl.0000000000003734  0.8
2017 Jun GR, Chung J, Mez J, Barber R, Beecham GW, Bennett DA, Buxbaum JD, Byrd GS, Carrasquillo MM, Crane PK, Cruchaga C, De Jager P, Ertekin-Taner N, Evans D, Fallin MD, ... ... Goate AM, et al. Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28183528 DOI: 10.1016/J.Jalz.2016.12.012  0.8
2017 Haddick PC, Larson JL, Rathore N, Bhangale TR, Phung QT, Srinivasan K, Hansen DV, Lill JR, Pericak-Vance MA, Haines J, Farrer LA, Kauwe JS, Schellenberg GD, Cruchaga C, ... Goate AM, et al. A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains. Journal of Alzheimer's Disease : Jad. PMID 28106546 DOI: 10.3233/Jad-160524  0.8
2017 Fernandez V, Budde JP, Saef B, Del-Aguila JL, Norton J, Chasse R, Morris JC, Goate A, Cruchaga C. Novel Candidate Variants In Load Detected By The Familial Alzheimer Sequencing (Fase) Project Alzheimers & Dementia. 13. DOI: 10.1016/J.Jalz.2017.07.190  0.8
2017 Hanseeuw BJ, McDade E, Schultz AP, Martins RN, Schofield PR, Masters CL, Graff-Radford NR, Salloway S, Danek A, Levin J, Buckles V, Goate AM, Benzinger TL, Morris JC, Bateman RJ, et al. GENOTYPIC VARIANCE MAY EXPLAIN THE BALANCE OF EARLY CORTICAL VERSUS STRIATAL AMYLOID DEPOSITION IN AUTOSOMAL DOMINANT AD Alzheimer's & Dementia. 13: P187-P188. DOI: 10.1016/J.Jalz.2017.07.043  0.36
2017 Lim YY, Hassenstab J, Cruchaga C, Goate AM, Fagan AM, Benzinger TLS, Maruff P, Masters CL, McDade E, Morris JC, Bateman RJ. Bdnf Val66Met Increases Rate Of Memory Decline, Hippocampal Volume Loss And Tau Accumulation In Autosomal Dominant Alzheimer’S Disease Alzheimers & Dementia. 13. DOI: 10.1016/J.Jalz.2017.06.283  0.8
2017 Joseph-Mathurin N, Kantarci K, Jack CR, Ringman JM, Salloway S, McDade E, Clifford D, Blazey T, Friedrichsen KA, Su Y, Gordon BA, Hornbeck RC, Mills S, Ances BM, Raichle ME, ... ... Goate A, et al. Clinical Risk Related To Cerebral Microhemorrhages In Autosomal Dominant Alzheimer’S Disease: Longitudinal Results From The Dian Study Alzheimers & Dementia. 13: 47. DOI: 10.1016/J.Jalz.2017.06.2330  0.8
2017 Joseph-Mathurin N, Su Y, Blazey T, Jasielec MS, Vlassenko AG, Friedrichsen KA, Gordon BA, Hornbeck RC, Cash L, Ances BM, Raichle ME, Brickman AM, Buckles V, Cairns NJ, Cruchaga C, ... ... Goate A, et al. Utility Of Perfusion Pet Models As Measures Of Neurodegeneration In An Autosomal Dominant Alzheimer’S Disease Population: Report From The Dian Study Alzheimers & Dementia. 13. DOI: 10.1016/J.Jalz.2017.06.1027  0.8
2016 Olfson E, Bloom J, Bertelsen S, Budde JP, Breslau N, Brooks A, Culverhouse R, Chan G, Chen LS, Chorlian D, Dick DM, Edenberg HJ, Hartz S, Hatsukami D, Hesselbrock VM, ... ... Goate A, et al. CYP2A6 metabolism in the development of smoking behaviors in young adults. Addiction Biology. PMID 28032407 DOI: 10.1111/Adb.12477  0.56
2016 Tcw J, Goate AM. Genetics of β-Amyloid Precursor Protein in Alzheimer's Disease. Cold Spring Harbor Perspectives in Medicine. PMID 28003277 DOI: 10.1101/Cshperspect.A024539  0.36
2016 Chapuis J, Flaig A, Grenier-Boley B, Eysert F, Pottiez V, Deloison G, Vandeputte A, Ayral AM, Mendes T, Desai S, Goate AM, Kauwe JS, Leroux F, Herledan A, Demiautte F, et al. Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. Acta Neuropathologica. PMID 27933404 DOI: 10.1007/S00401-016-1652-Z  0.8
2016 Monsell SE, Mock C, Fardo DW, Bertelsen S, Cairns NJ, Roe CM, Ellingson SR, Morris JC, Goate AM, Kukull WA. Genetic Comparison of Symptomatic and Asymptomatic Persons With Alzheimer Disease Neuropathology. Alzheimer Disease and Associated Disorders. PMID 27849641 DOI: 10.1097/Wad.0000000000000179  0.44
2016 Deming Y, Black K, Carrell D, Cai Y, Del-Aguila JL, Fernandez MV, Budde J, Ma S, Saef B, Howells B, Bertelsen S, Huang KL, Sutphen CL, Tarawneh R, Fagan AM, ... ... Goate AM, et al. Chitinase-3-like 1 protein (CHI3L1) locus influences cerebrospinal fluid levels of YKL-40. Bmc Neurology. 16: 217. PMID 27832767 DOI: 10.1186/S12883-016-0742-9  0.8
2016 Tang M, Ryman DC, McDade E, Jasielec MS, Buckles VD, Cairns NJ, Fagan AM, Goate A, Marcus DS, Xiong C, Allegri RF, Chhatwal JP, Danek A, Farlow MR, Fox NC, et al. Neurological manifestations of autosomal dominant familial Alzheimer's disease: a comparison of the published literature with the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS). The Lancet. Neurology. PMID 27777020 DOI: 10.1016/S1474-4422(16)30229-0  0.64
2016 Mez J, Chung J, Jun G, Kriegel J, Bourlas AP, Sherva R, Logue MW, Barnes LL, Bennett DA, Buxbaum JD, Byrd GS, Crane PK, Ertekin-Taner N, Evans D, Fallin MD, ... ... Goate A, et al. Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27770636 DOI: 10.1016/J.Jalz.2016.09.002  0.64
2016 Oni EN, Halikere A, Li G, Toro-Ramos AJ, Swerdel MR, Verpeut JL, Moore JC, Bello NT, Bierut LJ, Goate A, Tischfield JA, Pang ZP, Hart RP. Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele. Scientific Reports. 6: 34341. PMID 27698409 DOI: 10.1038/Srep34341  0.36
2016 Fernández MV, Black K, Carrell D, Saef B, Budde J, Deming Y, Howells B, Del-Aguila JL, Ma S, Bi C, Norton J, Chasse R, Morris J, Goate A, Cruchaga C, et al. SORL1 variants across Alzheimer's disease European American cohorts. European Journal of Human Genetics : Ejhg. PMID 27650968 DOI: 10.1038/Ejhg.2016.122  0.36
2016 Xu M, Lee EM, Wen Z, Cheng Y, Huang WK, Qian X, Tcw J, Kouznetsova J, Ogden SC, Hammack C, Jacob F, Nguyen HN, Itkin M, Hanna C, Shinn P, ... ... Goate A, et al. Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen. Nature Medicine. PMID 27571349 DOI: 10.1038/Nm.4184  0.36
2016 Tosto G, Bird TD, Bennett DA, Boeve BF, Brickman AM, Cruchaga C, Faber K, Foroud TM, Farlow M, Goate AM, Graff-Radford NR, Lantigua R, Manly J, Ottman R, Rosenberg R, et al. The Role of Cardiovascular Risk Factors and Stroke in Familial Alzheimer Disease. Jama Neurology. PMID 27533593 DOI: 10.1001/Jamaneurol.2016.2539  0.8
2016 Lim YY, Hassenstab J, Cruchaga C, Goate A, Fagan AM, Benzinger TL, Maruff P, Snyder PJ, Masters CL, Allegri R, Chhatwal J, Farlow MR, Graff-Radford NR, Laske C, Levin J, et al. BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease. Brain : a Journal of Neurology. PMID 27521573 DOI: 10.1093/Brain/Aww200  0.36
2016 Day GS, Musiek ES, Roe CM, Norton J, Goate AM, Cruchaga C, Cairns NJ, Morris JC. Phenotypic Similarities Between Late-Onset Autosomal Dominant and Sporadic Alzheimer Disease: A Single-Family Case-Control Study. Jama Neurology. PMID 27454811 DOI: 10.1016/J.Jalz.2016.06.1371  0.8
2016 Ebbert MT, Staley LA, Parker J, Parker S, Bailey M, Ridge PG, Goate AM, Kauwe JS. Variants in CCL16 are associated with blood plasma and cerebrospinal fluid CCL16 protein levels. Bmc Genomics. 17: 437. PMID 27357396 DOI: 10.1186/S12864-016-2788-X  0.36
2016 Staley LA, Ebbert MT, Bunker D, Bailey M, Ridge PG, Goate AM, Kauwe JS. Variants in ACPP are associated with cerebrospinal fluid Prostatic Acid Phosphatase levels. Bmc Genomics. 17: 439. PMID 27357282 DOI: 10.1186/S12864-016-2787-Y  0.36
2016 Staley LA, Ebbert MT, Parker S, Bailey M, Ridge PG, Goate AM, Kauwe JS. Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid. Bmc Genomics. 17: 436. PMID 27357110 DOI: 10.1186/S12864-016-2785-0  0.36
2016 Kauwe JS, Goate A. Genes for a 'Wellderly' Life. Trends in Molecular Medicine. PMID 27312143 DOI: 10.1016/J.Molmed.2016.05.011  0.44
2016 Sassi C, Nalls MA, Ridge PG, Gibbs JR, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Clement N, Lord J, Turton J, Bras J, ... ... Goate AM, et al. ABCA7 p.G215S as potential protective factor for Alzheimer's disease. Neurobiology of Aging. PMID 27289440 DOI: 10.1016/J.Neurobiolaging.2016.04.004  0.36
2016 Sassi C, Ridge PG, Nalls MA, Gibbs R, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Lord J, Turton J, Morgan K, ... ... Goate AM, et al. Influence of Coding Variability in APP-Aβ Metabolism Genes in Sporadic Alzheimer's Disease. Plos One. 11: e0150079. PMID 27249223 DOI: 10.1371/Journal.Pone.0150079  0.36
2016 Ridge PG, Hoyt KB, Boehme K, Mukherjee S, Crane PK, Haines JL, Mayeux R, Farrer LA, Pericak-Vance MA, Schellenberg GD, Kauwe JS. Assessment of the genetic variance of late-onset Alzheimer's disease. Neurobiology of Aging. PMID 27036079 DOI: 10.1016/J.Neurobiolaging.2016.02.024  0.36
2016 Lee S, Viqar F, Zimmerman ME, Narkhede A, Tosto G, Benzinger TL, Marcus DS, Fagan AM, Goate A, Fox NC, Cairns NJ, Holtzman DM, Buckles V, Ghetti B, McDade E, et al. White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the Dominantly Inherited Alzheimer Network. Annals of Neurology. PMID 27016429 DOI: 10.1016/J.Jalz.2015.07.133  0.36
2016 Karch CM, Ezerskiy LA, Bertelsen S, Goate AM. Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci. Plos One. 11: e0148717. PMID 26919393 DOI: 10.1371/Journal.Pone.0148717  1
2016 Traylor M, Adib-Samii P, Harold D, Dichgans M, Williams J, Lewis CM, Markus HS. Shared genetic contribution to Ischaemic Stroke and Alzheimer's Disease. Annals of Neurology. PMID 26913989 DOI: 10.1002/Ana.24621  0.36
2016 Deming Y, Xia J, Cai Y, Lord J, Del-Aguila JL, Fernandez MV, Carrell D, Black K, Budde J, Ma S, Saef B, Howells B, Bertelsen S, Bailey M, Ridge PG, ... ... Goate A, et al. Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits Scientific Reports. 6. DOI: 10.1038/Srep18092  0.36
2016 Petros J, Hassenstab J, Snitz BE, Zhou Y, Ringman JM, McDade E, Wang G, Balota DA, Aschenbrenner AJ, Benzinger TL, Cruchaga C, Fagan AM, Goate AM, Holtzman DM, Buckles V, et al. Dynamic Relationships Between “Big Five” Personality Traits, Alzheimer’S Disease Biomarkers, And Cognition In Autosomal Dominant Alzheimer’S Disease Alzheimers & Dementia. 12. DOI: 10.1016/J.Jalz.2016.06.970  0.8
2016 Buckles V, Xiong C, Weng H, Bateman R, Chhatwal JP, Ghetti B, Goate A, Graff-Radford NR, Hassenstab J, Mayeux R, Masters CL, McDade E, Moulder KL, Paumier KL, Ringman JM, et al. The Dian-Nacc Uds Comparison Study: Rates Of Cognitive Decline Alzheimers & Dementia. 12: 309. DOI: 10.1016/J.Jalz.2016.06.559  0.64
2016 Huang K, Jin SC, Harari O, Kapoor M, Bertelsen S, Czajkowski J, Lambert j, Chouraki V, Bellenguez C, Grenier-Boley B, Deming Y, McKenzie A, Renton AE, Budde J, Del-Aguila JL, ... ... Goate AM, et al. A Common Allele In Spi1 Lowers Risk And Delays Age At Onset For Alzheimer'S Disease Alzheimers & Dementia. 12: 253. DOI: 10.1016/J.Jalz.2016.06.453  0.8
2016 Deming Y, Harari O, Black K, Carrell D, Cai Y, Del-Aguila JL, Fernandez V, Budde J, Ma S, Saef B, Bertelsen S, Kauwe J, Fagan AM, Holtzman DM, Morris JC, ... ... Goate AM, et al. Cerebrospinal Fluid Levels Of Amyloid Beta And Tau As Endophenotypes Reveal Novel Variants Potentially Informative For Alzheimer'S Disease Alzheimers & Dementia. 12: 252. DOI: 10.1016/J.Jalz.2016.06.452  0.8
2016 Fernández MV, Budde J, Saef B, Carrell D, Howells B, Del-Aguila JL, Ma S, Norton J, Chasse R, Morris JC, Goate A, Cruchaga C. Novel Rare Variants In Known Genes, A Look Into The Familial Alzheimer Sequencing (Fase) Project Alzheimers & Dementia. 12: 198. DOI: 10.1016/J.Jalz.2016.06.345  0.8
2016 Fernández MV, Black K, Carrell D, Saef B, Budde J, Deming Y, Howells B, Del-Aguila JL, Ma S, Norton J, Chasse R, Morris JC, Goate A, Cruchaga C. Sorl1 Variants Across Alzheimer’S Disease Cohorts In European Americans Alzheimers & Dementia. 12: 857. DOI: 10.1016/J.Jalz.2016.06.1756  0.8
2016 Kauwe K, Arano I, Bras JT, Cannon-Albright L, Cruchaga C, Goate AM, Murcia JDG, Guerreiro R, Hardy J, Hsu S, Karch C, Munger RG, Norton MC, Ridge PG, Sassi C, et al. Linkage And Whole Genome Sequence Analysis Of Alzheimer'S Disease Resilience And Risk Alzheimers & Dementia. 12: 675. DOI: 10.1016/J.Jalz.2016.06.1325  0.8
2015 Ringman JM, Liang LJ, Zhou Y, Vangala S, Teng E, Kremen S, Wharton D, Goate A, Marcus DS, Farlow M, Ghetti B, McDade E, Masters CL, Mayeux RP, Rossor M, et al. Erratum: Early behavioural changes in familial Alzheimers disease in the Dominantly Inherited Alzheimer Network (Brain (2015) 138 (103645) (10.1093/brain/awv004)) Brain. 138. PMID 26598496 DOI: 10.1093/Brain/Awv210  0.64
2015 Haller G, Alvarado D, McCall K, Yang P, Cruchaga C, Harms M, Goate A, Willing M, Morcuende JA, Baschal E, Miller NH, Wise C, Dobbs MB, Gurnett CA. A polygenic burden of rare variants across extracellular matrix genes among individuals with adolescent idiopathic scoliosis. Human Molecular Genetics. PMID 26566670 DOI: 10.1093/Hmg/Ddv463  0.36
2015 Deming Y, Xia J, Cai Y, Lord J, Holmans P, Bertelsen S, Holtzman D, Morris JC, Bales K, Pickering EH, Kauwe J, Goate A, Cruchaga C. A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin. Neurobiology of Aging. PMID 26545630 DOI: 10.1016/J.Jalz.2015.07.374  0.36
2015 Escott-Price V, Sims R, Bannister C, Harold D, Vronskaya M, Majounie E, Badarinarayan N, Morgan K, Passmore P, Holmes C, Powell J, Brayne C, Gill M, ... ... Goate A, et al. Common polygenic variation enhances risk prediction for Alzheimer's disease. Brain : a Journal of Neurology. PMID 26490334 DOI: 10.1093/Brain/Awv268  0.36
2015 Barral S, Cheng R, Reitz C, Vardarajan B, Lee J, Kunkle B, Beecham G, Cantwell LS, Pericak-Vance MA, Farrer LA, Haines JL, Goate AM, Foroud T, Boerwinkle E, Schellenberg GD, et al. Linkage analyses in Caribbean Hispanic families identify novel loci associated with familial late-onset Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26433351 DOI: 10.1016/J.Jalz.2015.07.487  0.36
2015 Ghani M, Reitz C, Cheng R, Vardarajan BN, Jun G, Sato C, Naj A, Rajbhandary R, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, ... ... Goate AM, et al. Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals. Jama Neurology. PMID 26366463 DOI: 10.1001/Jamaneurol.2015.1700  0.36
2015 Kunkle BW, Jaworski J, Barral S, Vardarajan B, Beecham GW, Martin ER, Cantwell LS, Partch A, Bird TD, Raskind WH, DeStefano AL, Carney RM, Cuccaro M, Vance JM, Farrer LA, ... Goate AM, et al. Genome-wide linkage analyses of non-Hispanic white families identify novel loci for familial late-onset Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26365416 DOI: 10.1016/J.Jalz.2015.05.020  0.36
2015 Barral S, Vardarajan BN, Reyes-Dumeyer D, Faber KM, Bird TD, Tsuang D, Bennett DA, Rosenberg R, Boeve BF, Graff-Radford NR, Goate AM, Farlow M, Lantigua R, Medrano MZ, Wang X, et al. Genetic variants associated with susceptibility to psychosis in late-onset Alzheimer's disease families. Neurobiology of Aging. 36: 3116.e9-3116.e16. PMID 26359528 DOI: 10.1016/J.Neurobiolaging.2015.08.006  0.36
2015 Sadler B, Haller G, Edenberg H, Tischfield J, Brooks A, Kramer J, Schuckit M, Nurnberger J, Goate A. Positive Selection on Loci Associated with Drug and Alcohol Dependence. Plos One. 10: e0134393. PMID 26270548 DOI: 10.1371/Journal.Pone.0134393  1
2015 Wang F, Gordon BA, Ryman DC, Ma S, Xiong C, Hassenstab J, Goate A, Fagan AM, Cairns NJ, Marcus DS, McDade E, Ringman JM, Graff-Radford NR, Ghetti B, Farlow MR, et al. Cerebral amyloidosis associated with cognitive decline in autosomal dominant Alzheimer disease. Neurology. PMID 26245925 DOI: 10.1212/Wnl.0000000000001903  0.36
2015 Olfson E, Saccone NL, Johnson EO, Chen LS, Culverhouse R, Doheny K, Foltz SM, Fox L, Gogarten SM, Hartz S, Hetrick K, Laurie CC, Marosy B, Amin N, Arnett D, ... ... Goate A, et al. Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans. Molecular Psychiatry. PMID 26239294 DOI: 10.1038/Mp.2015.105  0.36
2015 Hancock DB, Wang JC, Gaddis NC, Levy JL, Saccone NL, Stitzel JA, Goate A, Bierut LJ, Johnson EO. A multiancestry study identifies novel genetic associations with CHRNA5 methylation in human brain and risk of nicotine dependence. Human Molecular Genetics. PMID 26220977 DOI: 10.1093/Hmg/Ddv303  0.36
2015 Hohman TJ, Cooke-Bailey JN, Reitz C, Jun G, Naj A, Beecham GW, Liu Z, Carney RM, Vance JM, Cuccaro ML, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, ... ... Goate AM, et al. Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26092349 DOI: 10.1016/J.Jalz.2015.02.012  1
2015 Mukherjee S, Walter S, Kauwe JS, Saykin AJ, Bennett DA, Larson EB, Crane PK, Glymour MM. Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples: Mendelian randomization analyses. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26079416 DOI: 10.1016/j.jalz.2015.05.015  0.36
2015 Patterson BW, Elbert DL, Mawuenyega KG, Kasten T, Ovod V, Ma S, Xiong C, Chott R, Yarasheski K, Sigurdson W, Zhang L, Goate A, Benzinger T, Morris JC, Holtzman D, et al. Age and amyloid effects on human CNS amyloid-beta kinetics. Annals of Neurology. PMID 26040676 DOI: 10.1002/Ana.24454  1
2015 Kotyuk E, Duchek J, Head D, Szekely A, Goate AM, Balota DA. A Genetic Variant (COMT) Coding Dopaminergic Activity Predicts Personality Traits in Healthy Elderly. Personality and Individual Differences. 82: 61-66. PMID 25960587 DOI: 10.1016/J.Paid.2015.03.012  1
2015 Jin SC, Carrasquillo MM, Benitez BA, Skorupa T, Carrell D, Patel D, Lincoln S, Krishnan S, Kachadoorian M, Reitz C, Mayeux R, Wingo TS, Lah JJ, Levey AI, Murrell J, ... ... Goate AM, et al. TREM2 is associated with increased risk for Alzheimer's disease in African Americans. Molecular Neurodegeneration. 10: 19. PMID 25886450 DOI: 10.1186/S13024-015-0016-9  1
2015 Cruchaga C, Goate AM. Cruchaga & Goate reply. Nature. 520: E5-6. PMID 25832412 DOI: 10.1038/Nature14037  1
2015 Cruchaga C, Goate AM. Cruchaga & Goate reply. Nature. 520: E10. PMID 25832409 DOI: 10.1038/nature14041  1
2015 Kim A, Fagan AM, Goate AM, Benzinger TL, Morris JC, Head D. Lack of an association of BDNF Val66Met polymorphism and plasma BDNF with hippocampal volume and memory. Cognitive, Affective & Behavioral Neuroscience. PMID 25784293 DOI: 10.3758/S13415-015-0343-X  1
2015 Jun G, Ibrahim-Verbaas CA, Vronskaya M, Lambert JC, Chung J, Naj AC, Kunkle BW, Wang LS, Bis JC, Bellenguez C, Harold D, Lunetta KL, Destefano AL, Grenier-Boley B, Sims R, ... ... Goate AM, et al. A novel Alzheimer disease locus located near the gene encoding tau protein. Molecular Psychiatry. PMID 25778476 DOI: 10.1038/Mp.2015.23  0.8
2015 Bailey HR, Sargent JQ, Flores S, Nowotny P, Goate A, Zacks JM. APOE ε4 genotype predicts memory for everyday activities. Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition. 1-28. PMID 25754878 DOI: 10.1080/13825585.2015.1020916  1
2015 Ringman JM, Liang LJ, Zhou Y, Vangala S, Teng E, Kremen S, Wharton D, Goate A, Marcus DS, Farlow M, Ghetti B, McDade E, Masters CL, Mayeux RP, Rossor M, et al. Early behavioural changes in familial Alzheimer's disease in the Dominantly Inherited Alzheimer Network. Brain : a Journal of Neurology. 138: 1036-45. PMID 25688083 DOI: 10.1093/Brain/Awv004  1
2015 . Convergent genetic and expression data implicate immunity in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 658-71. PMID 25533204 DOI: 10.1016/J.Jalz.2014.05.1757  1
2015 Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, ... ... Goate AM, et al. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. Jama Neurology. 72: 209-16. PMID 25531812 DOI: 10.1001/Jamaneurol.2014.2157  0.8
2015 Blednov YA, Benavidez JM, Black M, Ferguson LB, Schoenhard GL, Goate AM, Edenberg HJ, Wetherill L, Hesselbrock V, Foroud T, Harris RA. Peroxisome proliferator-activated receptors α and γ are linked with alcohol consumption in mice and withdrawal and dependence in humans. Alcoholism, Clinical and Experimental Research. 39: 136-45. PMID 25516156 DOI: 10.1111/Acer.12610  1
2015 Cady J, Allred P, Bali T, Pestronk A, Goate A, Miller TM, Mitra RD, Ravits J, Harms MB, Baloh RH. Amyotrophic lateral sclerosis onset is influenced by the burden of rare variants in known amyotrophic lateral sclerosis genes. Annals of Neurology. 77: 100-13. PMID 25382069 DOI: 10.1002/Ana.24306  1
2015 Karch CM, Goate AM. Alzheimer's disease risk genes and mechanisms of disease pathogenesis. Biological Psychiatry. 77: 43-51. PMID 24951455 DOI: 10.1016/J.Biopsych.2014.05.006  1
2015 Wetherill L, Agrawal A, Kapoor M, Bertelsen S, Bierut LJ, Brooks A, Dick D, Hesselbrock M, Hesselbrock V, Koller DL, Le N, Nurnberger JI, Salvatore JE, Schuckit M, Tischfield JA, ... ... Goate AM, et al. Association of substance dependence phenotypes in the COGA sample. Addiction Biology. 20: 617-27. PMID 24832863 DOI: 10.1111/Adb.12153  1
2015 Day GS, Lim TS, Hassenstab J, Grant EA, Goate A, Morris JC, Cairns NJ. Differentiating corticobasal degeneration and Alzheimer disease by longitudinal clinical and cognitive features Alzheimers & Dementia. 11: 525. DOI: 10.1016/J.Jalz.2015.06.646  0.64
2015 Del-Aguila JL, Gross AL, Sutti S, Sherva R, Mukherjee S, Crane PK, Goate A, Morris JC, Green RC, Cruchaga C. Identification of genetic variants associated with Alzheimer's disease: Progression rate Alzheimers & Dementia. 11: 487. DOI: 10.1016/J.Jalz.2015.06.552  0.8
2015 Tsuang D, Vardarajan BN, Bird TD, Boeve B, Schaid D, Taner N, Allen M, Barral S, Bennett DA, Cruchaga C, Goate A, Graff-Radford N, Faber K, Farlow MR, Foroud TM, et al. MAPT haplotypes modify the association between head injury and risk of Alzheimer’s disease Alzheimers & Dementia. 11: 361. DOI: 10.1016/J.Jalz.2015.06.256  0.8
2015 Monsell SE, Mock C, Fardo DW, Bertelsen S, Cairns NJ, Roe CM, Morris JC, Goate A, Kukull W. Genetic differences between symptomatic and asymptomatic persons with Alzheimer's disease neuropathologic change Alzheimers & Dementia. 11: 767. DOI: 10.1016/J.Jalz.2015.06.1711  0.64
2015 Joseph-Mathurin N, Tang M, Friedrichsen KA, Owen CJ, Su Y, Hornbeck RC, Stevenson TA, Cash L, Raichle ME, Gordon B, Preboske GM, Koeppe RA, Jack CR, Goate A, Cruchaga C, et al. Amyloid load increase and cerebral microbleed prevalence differ as a function of the position of the mutation within the PSEN1 coding sequence Alzheimers & Dementia. 11: 172. DOI: 10.1016/J.Jalz.2015.06.072  0.8
2015 Olfson E, Bloom J, Bertelsen S, Budde J, Hesselbrock V, Kramer J, Goate A, Bierut L. CYP2A6 metabolism in the development of nicotine dependence in adolescents and young adults Drug and Alcohol Dependence. 146. DOI: 10.1016/J.Drugalcdep.2014.09.524  0.68
2015 Ghani M, Reitz C, Cheng R, Vardarajan BN, Jun G, Sato C, Naj A, Rajbhandary R, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, ... ... Goate AM, et al. Association of long runs of homozygosity with Alzheimer disease among African American individuals Jama Neurology. 72: 1313-1323. DOI: 10.1001/jamaneurol.2015.1700z  0.36
2014 Wetzel-Smith MK, Hunkapiller J, Bhangale TR, Srinivasan K, Maloney JA, Atwal JK, Sa SM, Yaylaoglu MB, Foreman O, Ortmann W, Rathore N, Hansen DV, Tessier-Lavigne M, Mayeux R, ... ... Goate A, et al. A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death. Nature Medicine. 20: 1452-7. PMID 25419706 DOI: 10.1038/Nm.3736  0.36
2014 Izzo NJ, Xu J, Zeng C, Kirk MJ, Mozzoni K, Silky C, Rehak C, Yurko R, Look G, Rishton G, Safferstein H, Cruchaga C, Goate A, Cahill MA, Arancio O, et al. Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity. Plos One. 9: e111899. PMID 25390692 DOI: 10.1371/Journal.Pone.0111899  1
2014 Kauwe JS, Bailey MH, Ridge PG, Perry R, Wadsworth ME, Hoyt KL, Staley LA, Karch CM, Harari O, Cruchaga C, Ainscough BJ, Bales K, Pickering EH, Bertelsen S, ... ... Goate AM, et al. Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation. Plos Genetics. 10: e1004758. PMID 25340798 DOI: 10.1371/Journal.Pgen.1004758  1
2014 Olfson E, Edenberg HJ, Nurnberger J, Agrawal A, Bucholz KK, Almasy LA, Chorlian D, Dick DM, Hesselbrock VM, Kramer JR, Kuperman S, Porjesz B, Schuckit MA, Tischfield JA, Wang JC, ... ... Goate A, et al. An ADH1B variant and peer drinking in progression to adolescent drinking milestones: evidence of a gene-by-environment interaction. Alcoholism, Clinical and Experimental Research. 38: 2541-9. PMID 25257461 DOI: 10.1111/Acer.12524  1
2014 Proitsi P, Lupton MK, Velayudhan L, Newhouse S, Fogh I, Tsolaki M, Daniilidou M, Pritchard M, Kloszewska I, Soininen H, Mecocci P, Vellas B, Williams J, et al. Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease: a mendelian randomization analysis. Plos Medicine. 11: e1001713. PMID 25226301 DOI: 10.1371/Journal.Pmed.1001713  1
2014 Ringman JM, Goate A, Masters CL, Cairns NJ, Danek A, Graff-Radford N, Ghetti B, Morris JC. Genetic heterogeneity in Alzheimer disease and implications for treatment strategies. Current Neurology and Neuroscience Reports. 14: 499. PMID 25217249 DOI: 10.1007/S11910-014-0499-8  1
2014 Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, ... ... Goate AM, et al. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. Jama Neurology. 71: 1394-404. PMID 25199842 DOI: 10.1001/Jamaneurol.2014.1491  1
2014 Logue MW, Schu M, Vardarajan BN, Farrell J, Bennett DA, Buxbaum JD, Byrd GS, Ertekin-Taner N, Evans D, Foroud T, Goate A, Graff-Radford NR, Kamboh MI, Kukull WA, Manly JJ, et al. Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: 609-618.e11. PMID 25172201 DOI: 10.1016/J.Jalz.2014.06.010  1
2014 Bloom AJ, Hartz SM, Baker TB, Chen LS, Piper ME, Fox L, Martinez M, Hatsukami D, Johnson EO, Laurie CC, Saccone NL, Goate A, Bierut LJ. Beyond cigarettes per day. A genome-wide association study of the biomarker carbon monoxide. Annals of the American Thoracic Society. 11: 1003-10. PMID 25072098 DOI: 10.1513/Annalsats.201401-010Oc  1
2014 Thomas JB, Brier MR, Bateman RJ, Snyder AZ, Benzinger TL, Xiong C, Raichle M, Holtzman DM, Sperling RA, Mayeux R, Ghetti B, Ringman JM, Salloway S, McDade E, Rossor MN, ... ... Goate AM, et al. Functional connectivity in autosomal dominant and late-onset Alzheimer disease. Jama Neurology. 71: 1111-22. PMID 25069482 DOI: 10.1001/Jamaneurol.2014.1654  1
2014 Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, DeStefano AL, Kara E, Bras J, Sharma M, Schulte C, Keller MF, Arepalli S, Letson C, Edsall C, ... ... Goate A, et al. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nature Genetics. 46: 989-93. PMID 25064009 DOI: 10.1038/Ng.3043  0.36
2014 Ramirez A, van der Flier WM, Herold C, Ramonet D, Heilmann S, Lewczuk P, Popp J, Lacour A, Drichel D, Louwersheimer E, Kummer MP, Cruchaga C, Hoffmann P, Teunissen C, Holstege H, ... ... Goate A, et al. SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease. Human Molecular Genetics. 23: 6644-58. PMID 25027320 DOI: 10.1093/Hmg/Ddu372  0.36
2014 Karch CM, Cruchaga C, Goate AM. Alzheimer's disease genetics: from the bench to the clinic. Neuron. 83: 11-26. PMID 24991952 DOI: 10.1016/J.Neuron.2014.05.041  1
2014 Kapoor M, Wang JC, Wetherill L, Le N, Bertelsen S, Hinrichs AL, Budde J, Agrawal A, Almasy L, Bucholz K, Dick DM, Harari O, Xiaoling X, Hesselbrock V, Kramer J, ... ... Goate A, et al. Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families. Drug and Alcohol Dependence. 142: 56-62. PMID 24962325 DOI: 10.1016/J.Drugalcdep.2014.05.023  1
2014 Ryman DC, Acosta-Baena N, Aisen PS, Bird T, Danek A, Fox NC, Goate A, Frommelt P, Ghetti B, Langbaum JB, Lopera F, Martins R, Masters CL, Mayeux RP, McDade E, et al. Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis. Neurology. 83: 253-60. PMID 24928124 DOI: 10.1212/Wnl.0000000000000596  1
2014 Wang JC, Kapoor M, Goate AM. Association of genes involved in calcium and potassium pathways with opioid dependence. Biological Psychiatry. 76: 6-7. PMID 24925890 DOI: 10.1016/J.Biopsych.2014.04.012  1
2014 Escott-Price V, Bellenguez C, Wang LS, Choi SH, Harold D, Jones L, Holmans P, Gerrish A, Vedernikov A, Richards A, DeStefano AL, Lambert JC, Ibrahim-Verbaas CA, Naj AC, Sims R, ... ... Goate AM, et al. Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease. Plos One. 9: e94661. PMID 24922517 DOI: 10.1371/Journal.Pone.0094661  1
2014 Jin SC, Benitez BA, Karch CM, Cooper B, Skorupa T, Carrell D, Norton JB, Hsu S, Harari O, Cai Y, Bertelsen S, Goate AM, Cruchaga C. Coding variants in TREM2 increase risk for Alzheimer's disease. Human Molecular Genetics. 23: 5838-46. PMID 24899047 DOI: 10.1093/Hmg/Ddu277  1
2014 Haller G, Li P, Esch C, Hsu S, Goate AM, Steinbach JH. Functional characterization improves associations between rare non-synonymous variants in CHRNB4 and smoking behavior. Plos One. 9: e96753. PMID 24804708 DOI: 10.1371/Journal.Pone.0096753  1
2014 Sadler B, Haller G, Agrawal A, Culverhouse R, Bucholz K, Brooks A, Tischfield J, Johnson EO, Edenberg H, Schuckit M, Saccone N, Bierut L, Goate A. Variants near CHRNB3-CHRNA6 are associated with DSM-5 cocaine use disorder: evidence for pleiotropy. Scientific Reports. 4: 4497. PMID 24675634 DOI: 10.1038/Srep04497  1
2014 Fagan AM, Xiong C, Jasielec MS, Bateman RJ, Goate AM, Benzinger TL, Ghetti B, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Salloway S, Schofield PR, Sperling RA, et al. Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease. Science Translational Medicine. 6: 226ra30. PMID 24598588 DOI: 10.1126/Scitranslmed.3007901  1
2014 Harari O, Cruchaga C, Kauwe JS, Ainscough BJ, Bales K, Pickering EH, Bertelsen S, Fagan AM, Holtzman DM, Morris JC, Goate AM. Phosphorylated tau-Aβ42 ratio as a continuous trait for biomarker discovery for early-stage Alzheimer's disease in multiplex immunoassay panels of cerebrospinal fluid. Biological Psychiatry. 75: 723-31. PMID 24548642 DOI: 10.1016/J.Biopsych.2013.11.032  1
2014 Cady J, Koval ED, Benitez BA, Zaidman C, Jockel-Balsarotti J, Allred P, Baloh RH, Ravits J, Simpson E, Appel SH, Pestronk A, Goate AM, Miller TM, Cruchaga C, Harms MB. TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis. Jama Neurology. 71: 449-53. PMID 24535663 DOI: 10.1001/Jamaneurol.2013.6237  1
2014 Benitez BA, Jin SC, Guerreiro R, Graham R, Lord J, Harold D, Sims R, Lambert JC, Gibbs JR, Bras J, Sassi C, Harari O, Bertelsen S, Lupton MK, Powell J, ... ... Goate AM, et al. Missense variant in TREML2 protects against Alzheimer's disease. Neurobiology of Aging. 35: 1510.e19-26. PMID 24439484 DOI: 10.1016/J.Neurobiolaging.2013.12.010  1
2014 Vardarajan BN, Faber KM, Bird TD, Bennett DA, Rosenberg R, Boeve BF, Graff-Radford NR, Goate AM, Farlow M, Sweet RA, Lantigua R, Medrano MZ, Ottman R, Schaid DJ, Foroud TM, et al. Age-specific incidence rates for dementia and Alzheimer disease in NIA-LOAD/NCRAD and EFIGA families: National Institute on Aging Genetics Initiative for Late-Onset Alzheimer Disease/National Cell Repository for Alzheimer Disease (NIA-LOAD/NCRAD) and Estudio Familiar de Influencia Genetica en Alzheimer (EFIGA). Jama Neurology. 71: 315-23. PMID 24425039 DOI: 10.1001/Jamaneurol.2013.5570  1
2014 Ting SK, Benzinger T, Kepe V, Fagan A, Coppola G, Porter V, Hecimovic S, Chakraverty S, Alvarez-Retuerto AI, Goate A, Ringman JM. A novel PSEN1 mutation (I238M) associated with early-onset Alzheimer's disease in an African-American woman. Journal of Alzheimer's Disease : Jad. 40: 271-5. PMID 24413619 DOI: 10.3233/Jad-131844  1
2014 Culverhouse RC, Johnson EO, Breslau N, Hatsukami DK, Sadler B, Brooks AI, Hesselbrock VM, Schuckit MA, Tischfield JA, Goate AM, Saccone NL, Bierut LJ. Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans. Addiction (Abingdon, England). 109: 814-22. PMID 24401102 DOI: 10.1111/Add.12478  1
2014 Cruchaga C, Karch CM, Jin SC, Benitez BA, Cai Y, Guerreiro R, Harari O, Norton J, Budde J, Bertelsen S, Jeng AT, Cooper B, Skorupa T, Carrell D, Levitch D, ... ... Goate AM, et al. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease. Nature. 505: 550-4. PMID 24336208 DOI: 10.1038/Nature12825  1
2014 Agrawal A, Lynskey MT, Bucholz KK, Kapoor M, Almasy L, Dick DM, Edenberg HJ, Foroud T, Goate A, Hancock DB, Hartz S, Johnson EO, Hesselbrock V, Kramer JR, Kuperman S, et al. DSM-5 cannabis use disorder: a phenotypic and genomic perspective. Drug and Alcohol Dependence. 134: 362-9. PMID 24315570 DOI: 10.1016/J.Drugalcdep.2013.11.008  1
2014 Haller G, Kapoor M, Budde J, Xuei X, Edenberg H, Nurnberger J, Kramer J, Brooks A, Tischfield J, Almasy L, Agrawal A, Bucholz K, Rice J, Saccone N, Bierut L, ... Goate A, et al. Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence. Human Molecular Genetics. 23: 810-9. PMID 24057674 DOI: 10.1093/Hmg/Ddt463  1
2014 Bloom AJ, Baker TB, Chen LS, Breslau N, Hatsukami D, Bierut LJ, Goate A. Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms. Human Molecular Genetics. 23: 555-61. PMID 24045616 DOI: 10.1093/Hmg/Ddt432  1
2014 Chen LS, Bloom AJ, Baker TB, Smith SS, Piper ME, Martinez M, Saccone N, Hatsukami D, Goate A, Bierut L. Pharmacotherapy effects on smoking cessation vary with nicotine metabolism gene (CYP2A6). Addiction (Abingdon, England). 109: 128-37. PMID 24033696 DOI: 10.1111/Add.12353  1
2014 Wetherill L, Kapoor M, Agrawal A, Bucholz K, Koller D, Bertelsen SE, Le N, Wang JC, Almasy L, Hesselbrock V, Kramer J, Nurnberger JI, Schuckit M, Tischfield JA, Xuei X, ... ... Goate AM, et al. Family-based association analysis of alcohol dependence criteria and severity. Alcoholism, Clinical and Experimental Research. 38: 354-66. PMID 24015780 DOI: 10.1111/Acer.12251  1
2014 Peterson D, Munger C, Crowley J, Corcoran C, Cruchaga C, Goate AM, Norton MC, Green RC, Munger RG, Breitner JC, Welsh-Bohmer KA, Lyketsos C, Tschanz J, Kauwe JS. Variants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer's disease: the Cache County Dementia Progression Study. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: 366-71. PMID 23727081 DOI: 10.1016/J.Jalz.2013.02.010  1
2014 Dick DM, Cho SB, Latendresse SJ, Aliev F, Nurnberger JI, Edenberg HJ, Schuckit M, Hesselbrock VM, Porjesz B, Bucholz K, Wang JC, Goate A, Kramer JR, Kuperman S. Genetic influences on alcohol use across stages of development: GABRA2 and longitudinal trajectories of drunkenness from adolescence to young adulthood. Addiction Biology. 19: 1055-64. PMID 23692184 DOI: 10.1111/Adb.12066  1
2014 Yan J, Aliev F, Webb BT, Kendler KS, Williamson VS, Edenberg HJ, Agrawal A, Kos MZ, Almasy L, Nurnberger JI, Schuckit MA, Kramer JR, Rice JP, Kuperman S, Goate AM, et al. Using genetic information from candidate gene and genome-wide association studies in risk prediction for alcohol dependence. Addiction Biology. 19: 708-21. PMID 23362995 DOI: 10.1111/Adb.12035  1
2013 Wang JC, Spiegel N, Bertelsen S, Le N, McKenna N, Budde JP, Harari O, Kapoor M, Brooks A, Hancock D, Tischfield J, Foroud T, Bierut LJ, Steinbach JH, Edenberg HJ, ... ... Goate AM, et al. Cis-regulatory variants affect CHRNA5 mRNA expression in populations of African and European ancestry. Plos One. 8: e80204. PMID 24303001 DOI: 10.1371/Journal.Pone.0080204  1
2013 Bloom AJ, Martinez M, Chen LS, Bierut LJ, Murphy SE, Goate A. CYP2B6 non-coding variation associated with smoking cessation is also associated with differences in allelic expression, splicing, and nicotine metabolism independent of common amino-acid changes. Plos One. 8: e79700. PMID 24260284 DOI: 10.1371/Journal.Pone.0079700  1
2013 Benzinger TL, Blazey T, Jack CR, Koeppe RA, Su Y, Xiong C, Raichle ME, Snyder AZ, Ances BM, Bateman RJ, Cairns NJ, Fagan AM, Goate A, Marcus DS, Aisen PS, et al. Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 110: E4502-9. PMID 24194552 DOI: 10.1073/Pnas.1317918110  1
2013 Bloom AJ, von Weymarn LB, Martinez M, Bierut LJ, Goate A, Murphy SE. The contribution of common UGT2B10 and CYP2A6 alleles to variation in nicotine glucuronidation among European Americans. Pharmacogenetics and Genomics. 23: 706-16. PMID 24192532 DOI: 10.1097/Fpc.0000000000000011  1
2013 Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, DeStafano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thorton-Wells TA, Jones N, Smith AV, Chouraki V, ... ... Goate AM, et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nature Genetics. 45: 1452-8. PMID 24162737 DOI: 10.1038/Ng.2802  0.36
2013 Honea RA, Cruchaga C, Perea RD, Saykin AJ, Burns JM, Weinberger DR, Goate AM. Characterizing the role of brain derived neurotrophic factor genetic variation in Alzheimer's disease neurodegeneration. Plos One. 8: e76001. PMID 24086677 DOI: 10.1371/Journal.Pone.0076001  1
2013 Mills SM, Mallmann J, Santacruz AM, Fuqua A, Carril M, Aisen PS, Althage MC, Belyew S, Benzinger TL, Brooks WS, Buckles VD, Cairns NJ, Clifford D, Danek A, Fagan AM, ... ... Goate AM, et al. Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial. Revue Neurologique. 169: 737-43. PMID 24016464 DOI: 10.1016/J.Neurol.2013.07.017  1
2013 Benitez BA, Karch CM, Cai Y, Jin SC, Cooper B, Carrell D, Bertelsen S, Chibnik L, Schneider JA, Bennett DA, Fagan AM, Holtzman D, Morris JC, ... Goate AM, et al. The PSEN1, p.E318G variant increases the risk of Alzheimer's disease in APOE-ε4 carriers. Plos Genetics. 9: e1003685. PMID 23990795 DOI: 10.1371/Journal.Pgen.1003685  1
2013 McClintick JN, Xuei X, Tischfield JA, Goate A, Foroud T, Wetherill L, Ehringer MA, Edenberg HJ. Stress-response pathways are altered in the hippocampus of chronic alcoholics. Alcohol (Fayetteville, N.Y.). 47: 505-15. PMID 23981442 DOI: 10.1016/J.Alcohol.2013.07.002  1
2013 Chorlian DB, Rangaswamy M, Manz N, Wang JC, Dick D, Almasy L, Bauer L, Bucholz K, Foroud T, Hesselbrock V, Kang SJ, Kramer J, Kuperman S, Nurnberger J, Rice J, ... ... Goate A, et al. Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults. Behavior Genetics. 43: 386-401. PMID 23963516 DOI: 10.1007/S10519-013-9604-Z  1
2013 Frost SM, Kanagasingam Y, Sohrabi HR, Taddei K, Bateman R, Morris J, Benzinger T, Goate A, Masters CL, Martins RN. Pupil response biomarkers distinguish amyloid precursor protein mutation carriers from non-carriers. Current Alzheimer Research. 10: 790-6. PMID 23919771 DOI: 10.2174/15672050113109990154  1
2013 Chhatwal JP, Schultz AP, Johnson K, Benzinger TL, Jack C, Ances BM, Sullivan CA, Salloway SP, Ringman JM, Koeppe RA, Marcus DS, Thompson P, Saykin AJ, Correia S, Schofield PR, ... ... Goate AM, et al. Impaired default network functional connectivity in autosomal dominant Alzheimer disease. Neurology. 81: 736-44. PMID 23884042 DOI: 10.1212/Wnl.0B013E3182A1Aafe  1
2013 Campbell MC, Markham J, Flores H, Hartlein JM, Goate AM, Cairns NJ, Videen TO, Perlmutter JS. Principal component analysis of PiB distribution in Parkinson and Alzheimer diseases. Neurology. 81: 520-7. PMID 23825179 DOI: 10.1212/Wnl.0B013E31829E6F94  1
2013 Potter R, Patterson BW, Elbert DL, Ovod V, Kasten T, Sigurdson W, Mawuenyega K, Blazey T, Goate A, Chott R, Yarasheski KE, Holtzman DM, Morris JC, Benzinger TL, Bateman RJ. Increased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriers. Science Translational Medicine. 5: 189ra77. PMID 23761040 DOI: 10.1126/Scitranslmed.3005615  1
2013 Karch CM, Jeng AT, Skorupa T, Cruchaga C, Goate AM. Novel progranulin variants do not disrupt progranulin secretion and cleavage. Neurobiology of Aging. 34: 2538-40. PMID 23759146 DOI: 10.1016/J.Neurobiolaging.2013.05.004  1
2013 Kapoor M, Wang JC, Wetherill L, Le N, Bertelsen S, Hinrichs AL, Budde J, Agrawal A, Bucholz K, Dick D, Harari O, Hesselbrock V, Kramer J, Nurnberger JI, Rice J, ... ... Goate A, et al. A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks. Human Genetics. 132: 1141-51. PMID 23743675 DOI: 10.1007/S00439-013-1318-Z  1
2013 Zhang Z, Wang JC, Howells W, Lin P, Agrawal A, Edenberg HJ, Tischfield JA, Schuckit MA, Bierut LJ, Goate A, Rice JP. Dosage transmission disequilibrium test (dTDT) for linkage and association detection. Plos One. 8: e63526. PMID 23691058 DOI: 10.1371/Journal.Pone.0063526  1
2013 Kos MZ, Yan J, Dick DM, Agrawal A, Bucholz KK, Rice JP, Johnson EO, Schuckit M, Kuperman S, Kramer J, Goate AM, Tischfield JA, Foroud T, Nurnberger J, Hesselbrock V, et al. Common biological networks underlie genetic risk for alcoholism in African- and European-American populations. Genes, Brain, and Behavior. 12: 532-42. PMID 23607416 DOI: 10.1111/Gbb.12043  1
2013 Harms MB, Cady J, Zaidman C, Cooper P, Bali T, Allred P, Cruchaga C, Baughn M, Libby RT, Pestronk A, Goate A, Ravits J, Baloh RH. Lack of C9ORF72 coding mutations supports a gain of function for repeat expansions in amyotrophic lateral sclerosis. Neurobiology of Aging. 34: 2234.e13-9. PMID 23597494 DOI: 10.1016/J.Neurobiolaging.2013.03.006  1
2013 Harms M, Benitez BA, Cairns N, Cooper B, Cooper P, Mayo K, Carrell D, Faber K, Williamson J, Bird T, Diaz-Arrastia R, Foroud TM, Boeve BF, Graff-Radford NR, Mayeux R, ... ... Goate AM, et al. C9orf72 hexanucleotide repeat expansions in clinical Alzheimer disease. Jama Neurology. 70: 736-41. PMID 23588422 DOI: 10.1001/2013.Jamaneurol.537  1
2013 Reitz C, Jun G, Naj A, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, ... ... Goate AM, et al. Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans. Jama. 309: 1483-92. PMID 23571587 DOI: 10.1001/Jama.2013.2973  1
2013 Cruchaga C, Kauwe JS, Harari O, Jin SC, Cai Y, Karch CM, Benitez BA, Jeng AT, Skorupa T, Carrell D, Bertelsen S, Bailey M, McKean D, Shulman JM, De Jager PL, ... ... Goate AM, et al. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. Neuron. 78: 256-68. PMID 23562540 DOI: 10.1016/J.Neuron.2013.02.026  1
2013 Morgan EE, Woods SP, Letendre SL, Franklin DR, Bloss C, Goate A, Heaton RK, Collier AC, Marra CM, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Ellis RJ, et al. Apolipoprotein E4 genotype does not increase risk of HIV-associated neurocognitive disorders. Journal of Neurovirology. 19: 150-6. PMID 23408335 DOI: 10.1007/S13365-013-0152-3  1
2013 Bloom AJ, Harari O, Martinez M, Zhang X, McDonald SA, Murphy SE, Goate A. A compensatory effect upon splicing results in normal function of the CYP2A6*14 allele. Pharmacogenetics and Genomics. 23: 107-16. PMID 23292114 DOI: 10.1097/Fpc.0B013E32835Caf7D  1
2013 Bloom AJ, Murphy SE, Martinez M, von Weymarn LB, Bierut LJ, Goate A. Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption. Pharmacogenetics and Genomics. 23: 62-8. PMID 23211429 DOI: 10.1097/Fpc.0B013E32835C3B48  1
2013 Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, ... ... Goate A, et al. TREM2 variants in Alzheimer's disease. The New England Journal of Medicine. 368: 117-27. PMID 23150934 DOI: 10.1056/Nejmoa1211851  1
2013 Harms MB, Neumann D, Benitez BA, Cooper B, Carrell D, Racette BA, Perlmutter JS, Goate A, Cruchaga C. Parkinson disease is not associated with C9ORF72 repeat expansions. Neurobiology of Aging. 34: 1519.e1-2. PMID 23116878 DOI: 10.1016/J.Neurobiolaging.2012.10.001  1
2013 Wang JC, Foroud T, Hinrichs AL, Le NX, Bertelsen S, Budde JP, Harari O, Koller DL, Wetherill L, Agrawal A, Almasy L, Brooks AI, Bucholz K, Dick D, Hesselbrock V, ... ... Goate AM, et al. A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53. Molecular Psychiatry. 18: 1218-24. PMID 23089632 DOI: 10.1038/Mp.2012.143  1
2013 Karch CM, Jeng AT, Goate AM. Calcium phosphatase calcineurin influences tau metabolism. Neurobiology of Aging. 34: 374-86. PMID 22676853 DOI: 10.1016/J.Neurobiolaging.2012.05.003  1
2013 Reitz C, Jun G, Naj A, Vardarajan B, Wang L, Larson E, Graff-Radford N, Evans D, Jager PD, Crane P, Buxbaum J, Ertekin-Taner N, Logue M, Green R, Cantwell L, ... ... Goate A, et al. Association of TREM2 variants with Alzheimer's disease in African-Americans: For the Alzheimer's Disease Genetics Consortium (ADGC) Alzheimers & Dementia. 9: 175. DOI: 10.1016/J.Jalz.2013.05.284  0.64
2013 Vardarajan B, Bennett D, Bird T, Boeve B, Farlow M, Foroud T, Goate A, Graff-Radford N, Ottman R, Rosenberg RN, Schaid D, Sweet R, Tsuang D, Bennett J, Davis B, et al. Age-specific incidence rates of Alzheimer's disease in family members participating in the NIA-LOAD genetics study Alzheimers & Dementia. 9. DOI: 10.1016/J.Jalz.2013.05.1266  0.68
2013 Blazey T, Jack C, Kantarci K, Preboske G, Ringman J, Brickman A, Raichle M, Hornbeck R, Saykin A, Salloway S, McDade E, Rossor M, Fox N, Thompson P, Correia S, ... ... Goate A, et al. Prevalence and growth of cerebral microhemorrhages in autosomal dominant Alzheimer's disease Alzheimers & Dementia. 9. DOI: 10.1016/J.Jalz.2013.05.100  0.64
2013 Chhatwal J, Schultz A, Johnson K, Benzinger T, Jack C, Ances B, Sullivan C, Salloway S, Ringman J, Koeppe R, Marcus D, Thompson P, Saykin A, Correia S, Schofield P, ... ... Goate A, et al. IC-P-082: Disrupted functional connectivity in autosomal dominant Alzheimer's disease demonstrates network specificity and precedes brain volume loss: Findings from DIAN Alzheimer's & Dementia. 9: P49-P50. DOI: 10.1016/J.Jalz.2013.05.079  0.64
2013 Cash D, Ridgway G, Modat M, Ryan N, Kinnunen K, Cardoso J, Benzinger T, Jack CR, Raichle M, Marcus D, Ringman J, Thompson P, Ghetti B, Salloway S, Sperling R, ... ... Goate A, et al. Dissociating volume and intensity differences in familial Alzheimer's disease Alzheimers & Dementia. 9: 603. DOI: 10.1016/J.Jalz.2013.05.075  0.64
2013 Chhatwal J, Schultz A, Johnson K, Benzinger T, Jack C, Ances B, Sullivan C, Salloway S, Ringman J, Koeppe R, Marcus D, Thompson P, Saykin A, Correia S, Schofield P, ... ... Goate A, et al. O4-03-03: Disrupted functional connectivity in autosomal dominant Alzheimer's disease demonstrates network specificity and precedes brain volume loss: Findings from the Dominantly Inherited Alzheimer Network Alzheimer's & Dementia. 9: P684-P685. DOI: 10.1016/J.Jalz.2013.04.348  0.64
2013 Benitez B, Karch C, Jin SC, Carrel D, Cooper B, Bertelsen S, Morris J, Holtzman D, Goate A, Cruchaga C. Rare variants in APP and PSEN1 genes associated with extreme levels of beta-amyloid 42 and tau protein in cerebrospinal fluid Alzheimers & Dementia. 9: 680. DOI: 10.1016/J.Jalz.2013.04.338  0.8
2013 Hunkapiller J, Wetzel M, Bhangale T, Maloney J, Atwal J, Ortmann W, Tessier-Lavigne M, Goate A, Behrens T, Cruchaga C, Watts R, Graham R. A rare coding variant alters UNC5C function and predisposes to Alzheimer's disease Alzheimers & Dementia. 9: 311. DOI: 10.1016/J.Jalz.2013.04.125  0.8
2013 Kinnunen K, Ryan N, Cash D, Leite AB, Finnegan S, Cardoso M, Leung K, Modat M, Benzinger T, Jack C, Marcus D, Raichle M, Thompson P, Ringman J, Ghetti B, ... ... Goate A, et al. Are early atrophy patterns in autosomal dominant familial Alzheimer's disease gene-dependent? Alzheimers & Dementia. 9. DOI: 10.1016/J.Jalz.2013.04.017  0.64
2012 Harari O, Wang JC, Bucholz K, Edenberg HJ, Heath A, Martin NG, Pergadia ML, Montgomery G, Schrage A, Bierut LJ, Madden PF, Goate AM. Pathway analysis of smoking quantity in multiple GWAS identifies cholinergic and sensory pathways. Plos One. 7: e50913. PMID 23227220 DOI: 10.1371/Journal.Pone.0050913  1
2012 Karch CM, Jeng AT, Nowotny P, Cady J, Cruchaga C, Goate AM. Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains. Plos One. 7: e50976. PMID 23226438 DOI: 10.1371/Journal.Pone.0050976  1
2012 Morris JC, Aisen PS, Bateman RJ, Benzinger TL, Cairns NJ, Fagan AM, Ghetti B, Goate AM, Holtzman DM, Klunk WE, McDade E, Marcus DS, Martins RN, Masters CL, Mayeux R, et al. Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network. Clinical Investigation. 2: 975-984. PMID 23139856 DOI: 10.4155/Cli.12.93  0.44
2012 Karch CM, Jeng AT, Goate AM. Extracellular Tau levels are influenced by variability in Tau that is associated with tauopathies. The Journal of Biological Chemistry. 287: 42751-62. PMID 23105105 DOI: 10.1074/Jbc.M112.380642  1
2012 Jin SC, Pastor P, Cooper B, Cervantes S, Benitez BA, Razquin C, Goate A, Cruchaga C. Pooled-DNA sequencing identifies novel causative variants in PSEN1, GRN and MAPT in a clinical early-onset and familial Alzheimer's disease Ibero-American cohort. Alzheimer's Research & Therapy. 4: 34. PMID 22906081 DOI: 10.1186/Alzrt137  1
2012 Cruchaga C, Kauwe JS, Nowotny P, Bales K, Pickering EH, Mayo K, Bertelsen S, Hinrichs A, Fagan AM, Holtzman DM, Morris JC, Goate AM. Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease. Human Molecular Genetics. 21: 4558-71. PMID 22821396 DOI: 10.1093/Hmg/Dds296  1
2012 Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, Marcus DS, Cairns NJ, Xie X, Blazey TM, Holtzman DM, Santacruz A, Buckles V, Oliver A, Moulder K, et al. Clinical and biomarker changes in dominantly inherited Alzheimer's disease. The New England Journal of Medicine. 367: 795-804. PMID 22784036 DOI: 10.1056/Nejmoa1202753  1
2012 Wang JC, Kapoor M, Goate AM. The genetics of substance dependence. Annual Review of Genomics and Human Genetics. 13: 241-61. PMID 22703173 DOI: 10.1146/Annurev-Genom-090711-163844  1
2012 Lin P, Hartz SM, Wang JC, Agrawal A, Zhang TX, McKenna N, Bucholz K, Brooks AI, Tischfield JA, Edenberg HJ, Hesselbrock VM, Kramer JR, Kuperman S, Schuckit MA, Goate AM, et al. Copy number variations in 6q14.1 and 5q13.2 are associated with alcohol dependence. Alcoholism, Clinical and Experimental Research. 36: 1512-8. PMID 22702843 DOI: 10.1111/J.1530-0277.2012.01758.X  1
2012 Wildsmith KR, Basak JM, Patterson BW, Pyatkivskyy Y, Kim J, Yarasheski KE, Wang JX, Mawuenyega KG, Jiang H, Parsadanian M, Yoon H, Kasten T, Sigurdson WC, Xiong C, Goate A, et al. In vivo human apolipoprotein E isoform fractional turnover rates in the CNS. Plos One. 7: e38013. PMID 22675504 DOI: 10.1371/Journal.Pone.0038013  1
2012 Chen LS, Baker TB, Piper ME, Breslau N, Cannon DS, Doheny KF, Gogarten SM, Johnson EO, Saccone NL, Wang JC, Weiss RB, Goate AM, Bierut LJ. Interplay of genetic risk factors (CHRNA5-CHRNA3-CHRNB4) and cessation treatments in smoking cessation success. The American Journal of Psychiatry. 169: 735-42. PMID 22648373 DOI: 10.1176/Appi.Ajp.2012.11101545  1
2012 Kang SJ, Rangaswamy M, Manz N, Wang JC, Wetherill L, Hinrichs T, Almasy L, Brooks A, Chorlian DB, Dick D, Hesselbrock V, Kramer J, Kuperman S, Nurnberger J, Rice J, ... ... Goate A, et al. Family-based genome-wide association study of frontal θ oscillations identifies potassium channel gene KCNJ6. Genes, Brain, and Behavior. 11: 712-9. PMID 22554406 DOI: 10.1111/J.1601-183X.2012.00803.X  1
2012 Barral S, Bird T, Goate A, Farlow MR, Diaz-Arrastia R, Bennett DA, Graff-Radford N, Boeve BF, Sweet RA, Stern Y, Wilson RS, Foroud T, Ott J, Mayeux R. Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory. Neurology. 78: 1464-71. PMID 22539578 DOI: 10.1212/Wnl.0B013E3182553C48  1
2012 Chen LS, Saccone NL, Culverhouse RC, Bracci PM, Chen CH, Dueker N, Han Y, Huang H, Jin G, Kohno T, Ma JZ, Przybeck TR, Sanders AR, Smith JA, Sung YJ, ... ... Goate AM, et al. Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25. Genetic Epidemiology. 36: 340-51. PMID 22539395 DOI: 10.1002/Gepi.21627  1
2012 Rice JP, Hartz SM, Agrawal A, Almasy L, Bennett S, Breslau N, Bucholz KK, Doheny KF, Edenberg HJ, Goate AM, Hesselbrock V, Howells WB, Johnson EO, Kramer J, Krueger RF, et al. CHRNB3 is more strongly associated with Fagerström test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results. Addiction (Abingdon, England). 107: 2019-28. PMID 22524403 DOI: 10.1111/J.1360-0443.2012.03922.X  1
2012 Bloom AJ, Harari O, Martinez M, Madden PA, Martin NG, Montgomery GW, Rice JP, Murphy SE, Bierut LJ, Goate A. Use of a predictive model derived from in vivo endophenotype measurements to demonstrate associations with a complex locus, CYP2A6. Human Molecular Genetics. 21: 3050-62. PMID 22451501 DOI: 10.1093/Hmg/Dds114  1
2012 Shi H, Belbin O, Medway C, Brown K, Kalsheker N, Carrasquillo M, Proitsi P, Powell J, Lovestone S, Goate A, Younkin S, Passmore P, Morgan K. Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS). Neurobiology of Aging. 33: 1849.e5-18. PMID 22445811 DOI: 10.1016/J.Neurobiolaging.2012.02.014  1
2012 Kapoor M, Wang JC, Bertelsen S, Bucholz K, Budde JP, Hinrichs A, Agrawal A, Brooks A, Chorlian D, Dick D, Hesselbrock V, Foroud T, Kramer J, Kuperman S, Manz N, ... ... Goate AM, et al. Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking. Plos One. 7: e33513. PMID 22438940 DOI: 10.1371/Journal.Pone.0033513  1
2012 Derringer J, Krueger RF, Dick DM, Aliev F, Grucza RA, Saccone S, Agrawal A, Edenberg HJ, Goate AM, Hesselbrock VM, Kramer JR, Lin P, Neuman RJ, Nurnberger JI, Rice JP, et al. The aggregate effect of dopamine genes on dependence symptoms among cocaine users: cross-validation of a candidate system scoring approach. Behavior Genetics. 42: 626-35. PMID 22358648 DOI: 10.1007/S10519-012-9531-4  1
2012 Cruchaga C, Haller G, Chakraverty S, Mayo K, Vallania FL, Mitra RD, Faber K, Williamson J, Bird T, Diaz-Arrastia R, Foroud TM, Boeve BF, Graff-Radford NR, St Jean P, Lawson M, ... ... Goate AM, et al. Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families. Plos One. 7: e31039. PMID 22312439 DOI: 10.1371/Journal.Pone.0031039  1
2012 Agrawal A, Freedman ND, Cheng YC, Lin P, Shaffer JR, Sun Q, Taylor K, Yaspan B, Cole JW, Cornelis MC, DeSensi RS, Fitzpatrick A, Heiss G, Kang JH, O'Connell J, ... ... Goate A, et al. Measuring alcohol consumption for genomic meta-analyses of alcohol intake: opportunities and challenges. The American Journal of Clinical Nutrition. 95: 539-47. PMID 22301922 DOI: 10.3945/Ajcn.111.015545  1
2012 Head D, Bugg JM, Goate AM, Fagan AM, Mintun MA, Benzinger T, Holtzman DM, Morris JC. Exercise Engagement as a Moderator of the Effects of APOE Genotype on Amyloid Deposition. Archives of Neurology. 69: 636-43. PMID 22232206 DOI: 10.1001/Archneurol.2011.845  1
2012 Goate A, Hardy J. Twenty years of Alzheimer's disease-causing mutations. Journal of Neurochemistry. 120: 3-8. PMID 22122678 DOI: 10.1111/J.1471-4159.2011.07575.X  0.64
2012 Chen LS, Baker TB, Grucza R, Wang JC, Johnson EO, Breslau N, Hatsukami D, Smith SS, Saccone N, Saccone S, Rice JP, Goate AM, Bierut LJ. Dissection of the phenotypic and genotypic associations with nicotinic dependence. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 14: 425-33. PMID 22102629 DOI: 10.1093/Ntr/Ntr231  1
2012 Haller G, Druley T, Vallania FL, Mitra RD, Li P, Akk G, Steinbach JH, Breslau N, Johnson E, Hatsukami D, Stitzel J, Bierut LJ, Goate AM. Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence. Human Molecular Genetics. 21: 647-55. PMID 22042774 DOI: 10.1093/Hmg/Ddr498  1
2012 Gerrish A, Russo G, Richards A, Moskvina V, Ivanov D, Harold D, Sims R, Abraham R, Hollingworth P, Chapman J, Hamshere M, Pahwa JS, Dowzell K, Williams A, Jones N, ... ... Goate AM, et al. The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 28: 377-87. PMID 22027014 DOI: 10.3233/Jad-2011-110824  1
2012 Bierut LJ, Goate AM, Breslau N, Johnson EO, Bertelsen S, Fox L, Agrawal A, Bucholz KK, Grucza R, Hesselbrock V, Kramer J, Kuperman S, Nurnberger J, Porjesz B, Saccone NL, et al. ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry. Molecular Psychiatry. 17: 445-50. PMID 21968928 DOI: 10.1038/Mp.2011.124  1
2012 Becker J, Koeppe R, Benzinger T, Jack C, Marcus D, Raichle M, Thompson P, Saykin A, Correia S, Schofield P, Rowe C, Fox N, Brickman A, Ghetti B, Masters C, ... ... Goate A, et al. FDG metabolism in the DIAN study of autosomal dominant Alzheimer's disease Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.655  0.64
2012 Chhatwal J, Schultz A, Johnson K, Benzinger T, Jack C, Salloway S, Ringman J, Koeppe R, Marcus D, Thompson P, Saykin A, Correia S, Schofield P, Rowe C, Fox N, ... ... Goate A, et al. O2-06-01: Disrupted functional connectivity in autosomal dominant Alzheimer's disease: Preliminary findings from the DIAN study Alzheimer's & Dementia. 8: P244-P245. DOI: 10.1016/J.Jalz.2012.05.654  0.64
2012 Reitz C, Manly J, Hall KS, Evans D, Bennett D, Buxbaum J, Ertekin-Taner N, Fallin D, Kamboh I, Foroud T, Goate A, Farrer L, Pericak-Vance M, Haines J, Mayeux R, et al. CTNNA3, CAPRIN2 and SPG20 are significantly associated with Alzheimer's disease in preliminary analyses of a genome-wide association study in African-Americans Alzheimers & Dementia. 8: 100. DOI: 10.1016/J.Jalz.2012.05.251  0.64
2012 Kinnunen K, Cash D, Leung K, Liang Y, Cardoso M, Modat M, Malone I, Benzinger T, Koeppe R, Jack C, Raichle M, Marcus D, Ringman J, Thompson P, Saykin A, ... ... Goate A, et al. Brain and hippocampal rates of atrophy in familial Alzheimer's disease mutation carriers: Preliminary findings from the DIAN study Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.172  0.64
2012 Benzinger T, Blazey T, Koeppe R, Jack C, Raichle M, Su Y, Snyder A, Marcus D, Ringman J, Thompson P, Ghetti B, Saykin A, Salloway S, Correia S, Johnson K, ... ... Goate A, et al. Elevated PiB precedes dementia in autosomal dominant Alzheimer's disease: PiB, FDG and atrophy in the DIAN cohort Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.132  0.64
2012 Kinnunen K, Cash D, Liang Y, Leung K, Cardoso M, Modat M, Malone I, Yeatman T, Nicholas J, Benzinger T, Koeppe R, Jack C, Raichle M, Marcus D, Ringman J, ... ... Goate A, et al. Cross-sectional cerebral volumetric differences and associations with estimated time to age-at-onset in familial Alzheimer's disease: Findings from the DIAN study Alzheimers & Dementia. 8: 23. DOI: 10.1016/J.Jalz.2012.05.064  0.64
2012 Cash D, Ridgway G, Ryan N, Kinnunen K, Yeatman T, Malone I, Benzinger T, Koeppe R, Jack C, Raichle M, Marcus D, Ringman J, Thompson P, Saykin A, Salloway S, ... ... Goate A, et al. A voxel-based morphometry study of volumetric MRI in familial Alzheimer’s disease Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.052  0.64
2012 Bateman R, Benzinger T, Cairns N, Fagan A, Goate A, Marcus D, Storandt M, Xiong C, Buckles V, Holtzman D, Moulder K, Oliver A, Santacruz A, Fox N, Ghetti B, et al. Presymptomatic Alzheimer's disease in the Dominantly Inherited Alzheimer's Network (DIAN) Alzheimers & Dementia. 8: 4. DOI: 10.1016/J.Jalz.2012.05.015  0.64
2011 Holtzman DM, Goate A, Kelly J, Sperling R. Mapping the road forward in Alzheimer's disease. Science Translational Medicine. 3: 114ps48. PMID 22190237 DOI: 10.1126/Scitranslmed.3003529  1
2011 Vlassenko AG, Mintun MA, Xiong C, Sheline YI, Goate AM, Benzinger TL, Morris JC. Amyloid-beta plaque growth in cognitively normal adults: longitudinal [11C]Pittsburgh compound B data. Annals of Neurology. 70: 857-61. PMID 22162065 DOI: 10.1002/Ana.22608  1
2011 Benitez BA, Alvarado D, Cai Y, Mayo K, Chakraverty S, Norton J, Morris JC, Sands MS, Goate A, Cruchaga C. Exome-sequencing confirms DNAJC5 mutations as cause of adult neuronal ceroid-lipofuscinosis. Plos One. 6: e26741. PMID 22073189 DOI: 10.1371/Journal.Pone.0026741  1
2011 Latendresse SJ, Bates JE, Goodnight JA, Lansford JE, Budde JP, Goate A, Dodge KA, Pettit GS, Dick DM. Differential susceptibility to adolescent externalizing trajectories: examining the interplay between CHRM2 and peer group antisocial behavior. Child Development. 82: 1797-814. PMID 21883161 DOI: 10.1111/J.1467-8624.2011.01640.X  1
2011 Cruchaga C, Nowotny P, Kauwe JS, Ridge PG, Mayo K, Bertelsen S, Hinrichs A, Fagan AM, Holtzman DM, Morris JC, Goate AM. Association and expression analyses with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease. Archives of Neurology. 68: 1013-9. PMID 21825236 DOI: 10.1001/Archneurol.2011.155  1
2011 Lin P, Hartz SM, Wang JC, Krueger RF, Foroud TM, Edenberg HJ, Nurnberger JI, Brooks AI, Tischfield JA, Almasy L, Webb BT, Hesselbrock VM, Porjesz B, Goate AM, Bierut LJ, et al. Copy number variation accuracy in genome-wide association studies. Human Heredity. 71: 141-7. PMID 21778733 DOI: 10.1159/000324683  1
2011 Castellano JM, Kim J, Stewart FR, Jiang H, DeMattos RB, Patterson BW, Fagan AM, Morris JC, Mawuenyega KG, Cruchaga C, Goate AM, Bales KR, Paul SM, Bateman RJ, Holtzman DM. Human apoE isoforms differentially regulate brain amyloid-β peptide clearance. Science Translational Medicine. 3: 89ra57. PMID 21715678 DOI: 10.1126/Scitranslmed.3002156  1
2011 Hata S, Fujishige S, Araki Y, Taniguchi M, Urakami K, Peskind E, Akatsu H, Araseki M, Yamamoto K, Martins RN, Maeda M, Nishimura M, Levey A, Chung KA, Montine T, ... ... Goate A, et al. Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction. Annals of Neurology. 69: 1026-31. PMID 21681798 DOI: 10.1002/Ana.22343  1
2011 Agrawal A, Lynskey MT, Hinrichs A, Grucza R, Saccone SF, Krueger R, Neuman R, Howells W, Fisher S, Fox L, Cloninger R, Dick DM, Doheny KF, Edenberg HJ, Goate AM, et al. A genome-wide association study of DSM-IV cannabis dependence. Addiction Biology. 16: 514-8. PMID 21668797 DOI: 10.1111/J.1369-1600.2010.00255.X  1
2011 Page T, Gitcho MA, Mosaheb S, Carter D, Chakraverty S, Perry RH, Bigio EH, Gearing M, Ferrer I, Goate AM, Cairns NJ, Thorpe JR. FUS immunogold labeling TEM analysis of the neuronal cytoplasmic inclusions of neuronal intermediate filament inclusion disease: a frontotemporal lobar degeneration with FUS proteinopathy. Journal of Molecular Neuroscience : Mn. 45: 409-21. PMID 21603978 DOI: 10.1007/S12031-011-9549-8  1
2011 Bloom J, Hinrichs AL, Wang JC, von Weymarn LB, Kharasch ED, Bierut LJ, Goate A, Murphy SE. The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans. Pharmacogenetics and Genomics. 21: 403-16. PMID 21597399 DOI: 10.1097/Fpc.0B013E328346E8C0  1
2011 Heath AC, Whitfield JB, Martin NG, Pergadia ML, Goate AM, Lind PA, McEvoy BP, Schrage AJ, Grant JD, Chou YL, Zhu R, Henders AK, Medland SE, Gordon SD, Nelson EC, et al. A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications. Biological Psychiatry. 70: 513-8. PMID 21529783 DOI: 10.1016/J.Biopsych.2011.02.028  1
2011 Holtzman DM, Morris JC, Goate AM. Alzheimer's disease: the challenge of the second century. Science Translational Medicine. 3: 77sr1. PMID 21471435 DOI: 10.1126/Scitranslmed.3002369  0.44
2011 Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, ... ... Goate AM, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nature Genetics. 43: 436-41. PMID 21460841 DOI: 10.1038/Ng.801  0.8
2011 Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards A, ... ... Goate AM, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nature Genetics. 43: 429-35. PMID 21460840 DOI: 10.1038/Ng.803  1
2011 Dick DM, Meyers JL, Latendresse SJ, Creemers HE, Lansford JE, Pettit GS, Bates JE, Dodge KA, Budde J, Goate A, Buitelaar JK, Ormel J, Verhulst FC, Huizink AC. CHRM2, parental monitoring, and adolescent externalizing behavior: evidence for gene-environment interaction. Psychological Science. 22: 481-9. PMID 21441226 DOI: 10.1177/0956797611403318  1
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2011 Kauwe JS, Cruchaga C, Karch CM, Sadler B, Lee M, Mayo K, Latu W, Su'a M, Fagan AM, Holtzman DM, Morris JC, Goate AM. Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease. Plos One. 6: e15918. PMID 21347408 DOI: 10.1371/Journal.Pone.0015918  1
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2011 Culverhouse RC, Saccone NL, Stitzel JA, Wang JC, Steinbach JH, Goate AM, Schwantes-An TH, Grucza RA, Stevens VL, Bierut LJ. Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence. Human Genetics. 129: 177-88. PMID 21079997 DOI: 10.1007/S00439-010-0911-7  1
2011 Lenze EJ, Mantella RC, Shi P, Goate AM, Nowotny P, Butters MA, Andreescu C, Thompson PA, Rollman BL. Elevated cortisol in older adults with generalized anxiety disorder is reduced by treatment: a placebo-controlled evaluation of escitalopram. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. 19: 482-90. PMID 20808146 DOI: 10.1097/Jgp.0B013E3181Ec806C  1
2011 Jones L, Holmans PA, Hamshere ML, Harold D, Moskvina V, Ivanov D, Pocklington A, Abraham R, Hollingworth P, Sims R, Gerrish A, Pahwa JS, Jones N, Stretton A, Morgan AR, ... ... Goate AM, et al. Correction: Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease Plos One. 6. DOI: 10.1371/annotation/a0bb886d-d345-4a20-a82e-adce9b047798  0.88
2011 Ringman JM, Gylys KH, Medina LD, Fox M, Kepe V, Flores DL, Apostolova LG, Barrio JR, Small G, Silverman DH, Siu E, Cederbaum S, Hecimovic S, Malnar M, Chakraverty S, ... Goate AM, et al. Corrigendum to " Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation" [Neurosci. Lett. 487 (2011) 287-292] Neuroscience Letters. 491: 163. DOI: 10.1016/J.Neulet.2011.01.021  1
2011 Taylor-Reinwald L, Grant E, Goate A, Morris J, Cairns N. Neuropathology of preclinical and incipient Alzheimer's dementia Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.881  0.64
2011 Bennett DA, Bird T, Boeve B, Diaz-Arrastia R, Farlow M, Foroud T, Goate A, Graff-Radford N, Sweet R, Wilson R, Mayeux R. Multilocus genotype pattern at PICALM, CLU and APOE genes is associated with episodic memory in the NIA-LOAD/NCRAD study Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.562  0.64
2011 Shi H, Medway C, Brown K, Kalsheker N, Goate A, Proitsi P, Powell J, Lovestone S, Carrasquillo M, Younkin S. Genetic Variants Influencing Human Longevity from Late-Onset Alzheimer’s Disease (LOAD) Genome-Wide Association Studies (GWAS) Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.542  0.64
2011 Peterson D, Kauwe J, Crowley J, Corcoran C, Cruchaga C, Goate A, Norton M, Green R, Munger R, Breitner J, Welsh-Bohmer K, Lyketsos K, Tschanz J. Support for Genetic Association Between Variants in PPP3R1 and MAPT and Rate of Progression of Alzheimer’s Disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.533  0.8
2011 Cruchaga C, Kauwe J, Mayo K, Bertelsen S, Hinrichs T, Peskind E, Li G, Leverenz J, Galasko D, Fagan A, Holtzman D, Goate A. Genome-Wide Association Analyses Using Cerebrospinal Fluid Tau and Phospho-Tau Levels As An Endophenotype for Alzheimer’s Disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.503  0.8
2011 Benitez B, Cruchaga C, Kauwe J, Mayo K, Bertelsen S, Hinrichs A, Fagan A, Holtzman D, Goate A. Rare Genetic Variants in APP, PSEN1, PSEN2, GRN, APOE and MAPT Associated with CSF Aß and tau/ptau181 Levels in Patients with Late-Onset Alzheimer’s Disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.492  0.8
2011 Goate A, Holtzman D, Morris J, Cruchaga C, Nowotny P, Kauwe J, Fagan A, Mayo K, Bertelsen S, Hinrichs T. Association and expression analyses with SNPs in TOMM40 in Alzheimer's disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.227  0.8
2011 Kauwe J, Cruchaga C, McKean D, Bailey M, Patty D, Mayo K, Bertelsen S, Hinrichs A, Fagan A, Holtzman D, Goate A. Genome-wide association studies of CSF biomarkers Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.202  0.8
2011 Fagan A, Xiong C, Bateman R, Goate A, Holtzman D, Ghetti B, Martins R, Masters C, Mayeux R, Ringman J, Rossor M, Salloway S, Schofield P, Sperling R, Morris J. Plasma and Cerebrospinal Fluid Markers in the DIAN Study of Autosomal-Dominant Alzheimer’s Disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.1960  0.64
2010 Gao X, Joselin AP, Wang L, Kar A, Ray P, Bateman A, Goate AM, Wu JY. Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β. Protein & Cell. 1: 552-62. PMID 21204008 DOI: 10.1007/S13238-010-0067-1  1
2010 Sheline YI, Morris JC, Snyder AZ, Price JL, Yan Z, D'Angelo G, Liu C, Dixit S, Benzinger T, Fagan A, Goate A, Mintun MA. APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 17035-40. PMID 21159973 DOI: 10.1523/Jneurosci.3987-10.2010  1
2010 Lenze EJ, Goate AM, Nowotny P, Dixon D, Shi P, Bies RR, Lotrich FK, Rollman BL, Shear MK, Thompson PA, Andreescu C, Pollock BG. Relation of serotonin transporter genetic variation to efficacy of escitalopram for generalized anxiety disorder in older adults. Journal of Clinical Psychopharmacology. 30: 672-7. PMID 21105279 DOI: 10.1097/Jcp.0B013E3181Fc2Bef  1
2010 Jones L, Holmans PA, Hamshere ML, Harold D, Moskvina V, Ivanov D, Pocklington A, Abraham R, Hollingworth P, Sims R, Gerrish A, Pahwa JS, Jones N, Stretton A, Morgan AR, ... ... Goate AM, et al. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. Plos One. 5: e13950. PMID 21085570 DOI: 10.1371/Journal.Pone.0013950  1
2010 Cruchaga C, Kauwe JS, Mayo K, Spiegel N, Bertelsen S, Nowotny P, Shah AR, Abraham R, Hollingworth P, Harold D, Owen MM, Williams J, Lovestone S, Peskind ER, Li G, ... ... Goate AM, et al. SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease. Plos Genetics. 6: e1001101. PMID 20862329 DOI: 10.1371/Journal.Pgen.1001101  1
2010 Liang KY, Mintun MA, Fagan AM, Goate AM, Bugg JM, Holtzman DM, Morris JC, Head D. Exercise and Alzheimer's disease biomarkers in cognitively normal older adults. Annals of Neurology. 68: 311-8. PMID 20818789 DOI: 10.1002/Ana.22096  1
2010 Jun G, Naj AC, Beecham GW, Wang LS, Buros J, Gallins PJ, Buxbaum JD, Ertekin-Taner N, Fallin MD, Friedland R, Inzelberg R, Kramer P, Rogaeva E, St George-Hyslop P, ... ... Goate AM, et al. Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes. Archives of Neurology. 67: 1473-84. PMID 20697030 DOI: 10.1001/Archneurol.2010.201  1
2010 Kauwe JS, Cruchaga C, Bertelsen S, Mayo K, Latu W, Nowotny P, Hinrichs AL, Fagan AM, Holtzman DM, Goate AM. Validating predicted biological effects of Alzheimer's disease associated SNPs using CSF biomarker levels. Journal of Alzheimer's Disease : Jad. 21: 833-42. PMID 20634593 DOI: 10.3233/Jad-2010-091711  1
2010 Saccone NL, Schwantes-An TH, Wang JC, Grucza RA, Breslau N, Hatsukami D, Johnson EO, Rice JP, Goate AM, Bierut LJ. Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. Genes, Brain, and Behavior. 9: 741-50. PMID 20584212 DOI: 10.1111/J.1601-183X.2010.00608.X  1
2010 Malnar M, Kosicek M, Mitterreiter S, Omerbasic D, Lichtenthaler SF, Goate A, Hecimovic S. Niemann-Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the beta-secretase pathway. Biochimica Et Biophysica Acta. 1802: 682-91. PMID 20493254 DOI: 10.1016/J.Bbadis.2010.05.006  1
2010 Dick DM, Meyers J, Aliev F, Nurnberger J, Kramer J, Kuperman S, Porjesz B, Tischfield J, Edenberg HJ, Foroud T, Schuckit M, Goate A, Hesselbrock V, Bierut L. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 153: 1179-1188. PMID 20468071 DOI: 10.1002/Ajmg.B.31089  1
2010 Goate A, Holtzman DM. Biomarkers will revolutionize the way we diagnose and treat Alzheimer's disease. Biomarkers in Medicine. 4: 1-2. PMID 20387300 DOI: 10.2217/Bmm.10.3  1
2010 Chen AC, Manz N, Tang Y, Rangaswamy M, Almasy L, Kuperman S, Nurnberger J, O'Connor SJ, Edenberg HJ, Schuckit MA, Tischfield J, Foroud T, Bierut LJ, Rohrbaugh J, Rice JP, ... Goate A, et al. Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence. Alcoholism, Clinical and Experimental Research. 34: 988-96. PMID 20374216 DOI: 10.1111/J.1530-0277.2010.01173.X  1
2010 Lin P, Hartz SM, Zhang Z, Saccone SF, Wang J, Tischfield JA, Edenberg HJ, Kramer JR, M Goate A, Bierut LJ, Rice JP. A new statistic to evaluate imputation reliability. Plos One. 5: e9697. PMID 20300623 DOI: 10.1371/Journal.Pone.0009697  1
2010 Bierut LJ, Agrawal A, Bucholz KK, Doheny KF, Laurie C, Pugh E, Fisher S, Fox L, Howells W, Bertelsen S, Hinrichs AL, Almasy L, Breslau N, Culverhouse RC, Dick DM, ... ... Goate AM, et al. A genome-wide association study of alcohol dependence. Proceedings of the National Academy of Sciences of the United States of America. 107: 5082-7. PMID 20202923 DOI: 10.1073/Pnas.0911109107  1
2010 Edenberg HJ, Koller DL, Xuei X, Wetherill L, McClintick JN, Almasy L, Bierut LJ, Bucholz KK, Goate A, Aliev F, Dick D, Hesselbrock V, Hinrichs A, Kramer J, Kuperman S, et al. Genome-wide association study of alcohol dependence implicates a region on chromosome 11. Alcoholism, Clinical and Experimental Research. 34: 840-52. PMID 20201924 DOI: 10.1111/J.1530-0277.2010.01156.X  1
2010 Morris JC, Roe CM, Xiong C, Fagan AM, Goate AM, Holtzman DM, Mintun MA. APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging. Annals of Neurology. 67: 122-31. PMID 20186853 DOI: 10.1002/Ana.21843  1
2010 Kauwe JS, Bertelsen S, Mayo K, Cruchaga C, Abraham R, Hollingworth P, Harold D, Owen MJ, Williams J, Lovestone S, Morris JC, Goate AM. Suggestive synergy between genetic variants in TF and HFE as risk factors for Alzheimer's disease. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 153: 955-9. PMID 20029940 DOI: 10.1002/Ajmg.B.31053  1
2010 Wang J, Van Damme P, Cruchaga C, Gitcho MA, Vidal JM, Seijo-Martínez M, Wang L, Wu JY, Robberecht W, Goate A. Pathogenic cysteine mutations affect progranulin function and production of mature granulins Journal of Neurochemistry. 112: 1305-1315. PMID 20028451 DOI: 10.1111/J.1471-4159.2009.06546.X  1
2010 Edwards AC, Dodge KA, Latendresse SJ, Lansford JE, Bates JE, Pettit GS, Budde JP, Goate AM, Dick DM. MAOA-uVNTR and early physical discipline interact to influence delinquent behavior. Journal of Child Psychology and Psychiatry, and Allied Disciplines. 51: 679-87. PMID 19951362 DOI: 10.1111/J.1469-7610.2009.02196.X  1
2010 Hinrichs AL, Mintun MA, Head D, Fagan AM, Holtzman DM, Morris JC, Goate AM. Cortical binding of pittsburgh compound B, an endophenotype for genetic studies of Alzheimer's disease. Biological Psychiatry. 67: 581-3. PMID 19892322 DOI: 10.1016/J.Biopsych.2009.09.012  1
2010 Nelson EC, Agrawal A, Pergadia ML, Wang JC, Whitfield JB, Saccone FS, Kern J, Grant JD, Schrage AJ, Rice JP, Montgomery GW, Heath AC, Goate AM, Martin NG, Madden PA. H2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependence. Addiction Biology. 15: 1-11. PMID 19878140 DOI: 10.1111/J.1369-1600.2009.00181.X  1
2010 Xuei X, Flury-Wetherill L, Dick D, Goate A, Tischfield J, Nurnberger J, Schuckit M, Kramer J, Kuperman S, Hesselbrock V, Porjesz B, Foroud T, Edenberg HJ. GABRR1 and GABRR2, encoding the GABA-A receptor subunits ρ1 and ρ2, are associated with alcohol dependence American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 153: 418-427. PMID 19536785 DOI: 10.1002/Ajmg.B.30995  1
2010 Cruchaga C, Chakraverty S, Haller G, Kevin M, Vallania FL, Robi MD, Bird TD, Diaz-Arrestia R, Boeve B, Bradley B, Graff-Radford NR, Mayeux R, Goate A. Implications and frequency of APP, PSEN1, PSEN2, GRN and MAPT mutation in a well-characterized series of late-onset Alzheimer families Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.615  0.8
2010 Cruchaga C, Kauwe JS, Mayo K, Bertelsen S, Nowotny P, Shah AR, Abraham R, Hollingworth P, Harold D, Owen MJ, Williams J, Lovestone S, Morris JC, Fagan AM, Holtzman DM, ... Goate AM, et al. SNPs associated with CSF tau levels modify rate of progression in Alzheimer's disease Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.612  0.88
2010 Kauwe JSK, Cruchaga C, Bertelsen S, Mayo K, Latu W, Nowotny P, Hinrichs AL, Fagan AM, Holtzman DM, Goate AM. Validating predicted biological effects of Alzheimer's disease associated SNPs using cerebrospinal fluid biomarker levels Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.348  0.8
2009 Chen LS, Johnson EO, Breslau N, Hatsukami D, Saccone NL, Grucza RA, Wang JC, Hinrichs AL, Fox L, Goate AM, Rice JP, Bierut LJ. Interplay of Genetic Risk Factors and Parent Monitoring in Risk for Nicotine Dependence. Addiction (Abingdon, England). 104: 1731-1740. PMID 20871796 DOI: 10.1111/J.1360-0443.2009.02697.X  1
2009 Morris JC, Roe CM, Grant EA, Head D, Storandt M, Goate AM, Fagan AM, Holtzman DM, Mintun MA. Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease. Archives of Neurology. 66: 1469-75. PMID 20008650 DOI: 10.1001/Archneurol.2009.269  1
2009 Blom ES, Giedraitis V, Arepalli S, Hamshere ML, Adighibe O, Goate A, Williams J, Lannfelt L, Hardy J, Vrièze FW, Glaser A. Further analysis of previously implicated linkage regions for Alzheimer's disease in affected relative pairs. Bmc Medical Genetics. 10: 122. PMID 19951422 DOI: 10.1186/1471-2350-10-122  1
2009 Simón-Sánchez J, Schulte C, Bras JM, Sharma M, Gibbs JR, Berg D, Paisan-Ruiz C, Lichtner P, Scholz SW, Hernandez DG, Krüger R, Federoff M, Klein C, Goate A, Perlmutter J, et al. Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nature Genetics. 41: 1308-12. PMID 19915575 DOI: 10.1038/Ng.487  1
2009 Duchek JM, Balota DA, Tse CS, Holtzman DM, Fagan AM, Goate AM. The utility of intraindividual variability in selective attention tasks as an early marker for Alzheimer's disease. Neuropsychology. 23: 746-58. PMID 19899833 DOI: 10.1037/A0016583  1
2009 Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, ... ... Goate AM, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nature Genetics. 41: 1088-93. PMID 19734902 DOI: 10.1038/Ng.440  0.88
2009 Wang JC, Bierut LJ, Goate AM. Variants weakly correlated with CHRNA5 D398N polymorphism should be considered in transcriptional deregulation at the 15q25 locus associated with lung cancer risk. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 5599; author reply 5. PMID 19706810 DOI: 10.1158/1078-0432.Ccr-09-1108  1
2009 Saccone NL, Wang JC, Breslau N, Johnson EO, Hatsukami D, Saccone SF, Grucza RA, Sun L, Duan W, Budde J, Culverhouse RC, Fox L, Hinrichs AL, Steinbach JH, Wu M, ... ... Goate AM, et al. The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Cancer Research. 69: 6848-56. PMID 19706762 DOI: 10.1158/0008-5472.Can-09-0786  1
2009 Norton JB, Cairns NJ, Chakraverty S, Wang J, Levitch D, Galvin JE, Goate A. Presenilin1 G217R mutation linked to Alzheimer disease with cotton wool plaques. Neurology. 73: 480-2. PMID 19667325 DOI: 10.1212/Wnl.0B013E3181B163Ba  1
2009 Fenoglio C, Galimberti D, Cortini F, Kauwe JS, Cruchaga C, Venturelli E, Villa C, Serpente M, Scalabrini D, Mayo K, Piccio LM, Clerici F, Albani D, Mariani C, Forloni G, ... ... Goate AM, et al. Rs5848 variant influences GRN mRNA levels in brain and peripheral mononuclear cells in patients with Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 18: 603-12. PMID 19625741 DOI: 10.3233/Jad-2009-1170  1
2009 Gitcho MA, Bigio EH, Mishra M, Johnson N, Weintraub S, Mesulam M, Rademakers R, Chakraverty S, Cruchaga C, Morris JC, Goate AM, Cairns NJ. TARDBP 3'-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy. Acta Neuropathologica. 118: 633-45. PMID 19618195 DOI: 10.1007/S00401-009-0571-7  1
2009 Dick DM, Latendresse SJ, Lansford JE, Budde JP, Goate A, Dodge KA, Pettit GS, Bates JE. Role of GABRA2 in trajectories of externalizing behavior across development and evidence of moderation by parental monitoring. Archives of General Psychiatry. 66: 649-57. PMID 19487630 DOI: 10.1001/Archgenpsychiatry.2009.48  1
2009 Wang JC, Cruchaga C, Saccone NL, Bertelsen S, Liu P, Budde JP, Duan W, Fox L, Grucza RA, Kern J, Mayo K, Reyes O, Rice J, Saccone SF, Spiegel N, ... ... Goate AM, et al. Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. Human Molecular Genetics. 18: 3125-35. PMID 19443489 DOI: 10.1093/Hmg/Ddp231  1
2009 Lester HA, Xiao C, Srinivasan R, Son CD, Miwa J, Pantoja R, Banghart MR, Dougherty DA, Goate AM, Wang JC. Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery. The Aaps Journal. 11: 167-77. PMID 19280351 DOI: 10.1208/S12248-009-9090-7  1
2009 Saccone NL, Saccone SF, Hinrichs AL, Stitzel JA, Duan W, Pergadia ML, Agrawal A, Breslau N, Grucza RA, Hatsukami D, Johnson EO, Madden PA, Swan GE, Wang JC, Goate AM, et al. Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 150: 453-66. PMID 19259974 DOI: 10.1002/Ajmg.B.30828  1
2009 Gitcho MA, Strider J, Carter D, Taylor-Reinwald L, Forman MS, Goate AM, Cairns NJ. VCP mutations causing frontotemporal lobar degeneration disrupt localization of TDP-43 and induce cell death. The Journal of Biological Chemistry. 284: 12384-98. PMID 19237541 DOI: 10.1074/Jbc.M900992200  1
2009 Nelson EC, Agrawal A, Pergadia ML, Lynskey MT, Todorov AA, Wang JC, Todd RD, Martin NG, Heath AC, Goate AM, Montgomery GW, Madden PA. Association of childhood trauma exposure and GABRA2 polymorphisms with risk of posttraumatic stress disorder in adults. Molecular Psychiatry. 14: 234-5. PMID 19229201 DOI: 10.1038/Mp.2008.81  1
2009 Agrawal A, Pergadia ML, Balasubramanian S, Saccone SF, Hinrichs AL, Saccone NL, Breslau N, Johnson EO, Hatsukami D, Martin NG, Montgomery GW, Goate AM, Rice JP, Bierut LJ, Madden PA. Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine Dependence. Addiction (Abingdon, England). 104: 471-7. PMID 19207358 DOI: 10.1111/J.1360-0443.2008.02445.X  1
2009 Pergadia ML, Agrawal A, Loukola A, Montgomery GW, Broms U, Saccone SF, Wang JC, Todorov AA, Heikkilä K, Statham DJ, Henders AK, Campbell MJ, Rice JP, Todd RD, Heath AC, ... Goate AM, et al. Genetic linkage findings for DSM-IV nicotine withdrawal in two populations. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 150: 950-9. PMID 19180564 DOI: 10.1002/Ajmg.B.30924  1
2009 Kauwe JS, Wang J, Mayo K, Morris JC, Fagan AM, Holtzman DM, Goate AM. Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta. Neurogenetics. 10: 13-7. PMID 18813964 DOI: 10.1007/S10048-008-0150-4  1
2009 Chen AC, Tang Y, Rangaswamy M, Wang JC, Almasy L, Foroud T, Edenberg HJ, Hesselbrock V, Nurnberger J, Kuperman S, O'Connor SJ, Schuckit MA, Bauer LO, Tischfield J, Rice JP, ... ... Goate A, et al. Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 150: 359-68. PMID 18618593 DOI: 10.1002/Ajmg.B.30818  1
2009 Wang JC, Grucza R, Cruchaga C, Hinrichs AL, Bertelsen S, Budde JP, Fox L, Goldstein E, Reyes O, Saccone N, Saccone S, Xuei X, Bucholz K, Kuperman S, Nurnberger J, ... ... Goate AM, et al. Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence. Molecular Psychiatry. 14: 501-10. PMID 18414406 DOI: 10.1038/Mp.2008.42  1
2008 Stevens VL, Bierut LJ, Talbot JT, Wang JC, Sun J, Hinrichs AL, Thun MJ, Goate A, Calle EE. Nicotinic receptor gene variants influence susceptibility to heavy smoking. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 17: 3517-25. PMID 19029397 DOI: 10.1158/1055-9965.Epi-08-0585  1
2008 Saccone NL, Saccone SF, Goate AM, Grucza RA, Hinrichs AL, Rice JP, Bierut LJ. In search of causal variants: refining disease association signals using cross-population contrasts. Bmc Genetics. 9: 58. PMID 18759969 DOI: 10.1186/1471-2156-9-58  1
2008 Hogue CW, Fucetola R, Hershey T, Freedland K, Dávila-Román VG, Goate AM, Thompson RE. Risk factors for neurocognitive dysfunction after cardiac surgery in postmenopausal women. The Annals of Thoracic Surgery. 86: 511-6. PMID 18640325 DOI: 10.1016/J.Athoracsur.2008.04.058  1
2008 Saccone SF, Saccone NL, Swan GE, Madden PA, Goate AM, Rice JP, Bierut LJ. Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence. Bioinformatics (Oxford, England). 24: 1805-11. PMID 18565990 DOI: 10.1093/Bioinformatics/Btn315  1
2008 Kauwe JS, Cruchaga C, Mayo K, Fenoglio C, Bertelsen S, Nowotny P, Galimberti D, Scarpini E, Morris JC, Fagan AM, Holtzman DM, Goate AM. Variation in MAPT is associated with cerebrospinal fluid tau levels in the presence of amyloid-beta deposition. Proceedings of the National Academy of Sciences of the United States of America. 105: 8050-4. PMID 18541914 DOI: 10.1073/Pnas.0801227105  1
2008 Agrawal A, Pergadia ML, Saccone SF, Lynskey MT, Wang JC, Martin NG, Statham D, Henders A, Campbell M, Garcia R, Broms U, Todd RD, Goate AM, Rice J, Kaprio J, et al. An autosomal linkage scan for cannabis use disorders in the nicotine addiction genetics project. Archives of General Psychiatry. 65: 713-21. PMID 18519829 DOI: 10.1001/Archpsyc.65.6.713  1
2008 Bierut LJ, Stitzel JA, Wang JC, Hinrichs AL, Grucza RA, Xuei X, Saccone NL, Saccone SF, Bertelsen S, Fox L, Horton WJ, Breslau N, Budde J, Cloninger CR, Dick DM, ... ... Goate AM, et al. Variants in nicotinic receptors and risk for nicotine dependence. The American Journal of Psychiatry. 165: 1163-71. PMID 18519524 DOI: 10.1176/Appi.Ajp.2008.07111711  1
2008 Grucza RA, Wang JC, Stitzel JA, Hinrichs AL, Saccone SF, Saccone NL, Bucholz KK, Cloninger CR, Neuman RJ, Budde JP, Fox L, Bertelsen S, Kramer J, Hesselbrock V, Tischfield J, ... ... Goate AM, et al. A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence. Biological Psychiatry. 64: 922-9. PMID 18519132 DOI: 10.1016/J.Biopsych.2008.04.018  1
2008 Agrawal A, Pergadia ML, Saccone SF, Hinrichs AL, Lessov-Schlaggar CN, Saccone NL, Neuman RJ, Breslau N, Johnson E, Hatsukami D, Montgomery GW, Heath AC, Martin NG, Goate AM, Rice JP, et al. Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control study. Addiction (Abingdon, England). 103: 1027-38. PMID 18482426 DOI: 10.1111/J.1360-0443.2008.02236.X  1
2008 Kauwe JS, Wang J, Chakraverty S, Goate AM, Henao-Martinez AF. Novel presenilin 1 variant (P117A) causing Alzheimer's disease in the fourth decade of life. Neuroscience Letters. 438: 257-9. PMID 18479822 DOI: 10.1016/J.Neulet.2008.04.029  1
2008 Ghosh S, Bierut LJ, Porjesz B, Edenberg HJ, Dick D, Goate A, Hesselbrock V, Nurnberger J, Foroud T, Kramer J, Rice J, Begleiter H. A novel non-parametric regression reveals linkage on chromosome 4 for the number of externalizing symptoms in sib-pairs American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 147: 1301-1305. PMID 18454434 DOI: 10.1002/Ajmg.B.30735  1
2008 Edenberg HJ, Wang J, Tian H, Pochareddy S, Xuei X, Wetherill L, Goate A, Hinrichs T, Kuperman S, Nurnberger JI, Schuckit M, Tischfield JA, Foroud T. A regulatory variation in OPRK1, the gene encoding the kappa-opioid receptor, is associated with alcohol dependence. Human Molecular Genetics. 17: 1783-9. PMID 18319328 DOI: 10.1093/Hmg/Ddn068  1
2008 Dick DM, Aliev F, Wang JC, Grucza RA, Schuckit M, Kuperman S, Kramer J, Hinrichs A, Bertelsen S, Budde JP, Hesselbrock V, Porjesz B, Edenberg HJ, Bierut LJ, Goate A. Using dimensional models of externalizing psychopathology to aid in gene identification. Archives of General Psychiatry. 65: 310-8. PMID 18316677 DOI: 10.1001/Archpsyc.65.3.310  1
2008 Gitcho MA, Baloh RH, Chakraverty S, Mayo K, Norton JB, Levitch D, Hatanpaa KJ, White CL, Bigio EH, Caselli R, Baker M, Al-Lozi MT, Morris JC, Pestronk A, Rademakers R, ... Goate AM, et al. TDP-43 A315T mutation in familial motor neuron disease. Annals of Neurology. 63: 535-8. PMID 18288693 DOI: 10.1002/Ana.21344  1
2008 Mukherjee O, Wang J, Gitcho M, Chakraverty S, Taylor-Reinwald L, Shears S, Kauwe JS, Norton J, Levitch D, Bigio EH, Hatanpaa KJ, White CL, Morris JC, Cairns NJ, Goate A. Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia. Human Mutation. 29: 512-21. PMID 18183624 DOI: 10.1002/Humu.20681  0.68
2008 Dick DM, Aliev F, Wang JC, Saccone S, Hinrichs A, Bertelsen S, Budde J, Saccone N, Foroud T, Nurnberger J, Xuei X, Conneally PM, Schuckit M, Almasy L, Crowe R, ... ... Goate A, et al. A Systematic single nucleotide polymorphism screen to fine-map alcohol dependence genes on chromosome 7 identifies association with a novel susceptibility gene ACN9. Biological Psychiatry. 63: 1047-53. PMID 18163977 DOI: 10.1016/J.Biopsych.2007.11.005  1
2008 Blom ES, Holmans P, Arepalli S, Adighibe O, Hamshere ML, Gatz M, Pedersen NL, Bergem AL, Owen MJ, Hollingworth P, Goate A, Williams J, Lannfelt L, Hardy J, Wavrant-De Vrièze F, et al. Does APOE explain the linkage of Alzheimer's disease to chromosome 19q13? American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 147: 778-83. PMID 18161859 DOI: 10.1002/Ajmg.B.30681  1
2008 Li Y, Grupe A, Rowland C, Holmans P, Segurado R, Abraham R, Jones L, Catanese J, Ross D, Mayo K, Martinez M, Hollingworth P, Goate A, Cairns NJ, Racette BA, et al. Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease. Human Molecular Genetics. 17: 759-67. PMID 18063669 DOI: 10.1093/Hmg/Ddm348  1
2008 Li Y, Rowland C, Catanese J, Morris J, Lovestone S, O'Donovan MC, Goate A, Owen M, Williams J, Grupe A. SORL1 variants and risk of late-onset Alzheimer's disease. Neurobiology of Disease. 29: 293-6. PMID 17949987 DOI: 10.1016/J.Nbd.2007.09.001  1
2008 Agrawal A, Hinrichs AL, Dunn G, Bertelsen S, Dick DM, Saccone SF, Saccone NL, Grucza RA, Wang JC, Cloninger CR, Edenberg HJ, Foroud T, Hesselbrock V, Kramer J, Bucholz KK, ... ... Goate AM, et al. Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample. Drug and Alcohol Dependence. 93: 12-20. PMID 17942244 DOI: 10.1016/J.Drugalcdep.2007.08.015  1
2008 Fenoglio C, Cortini F, Venturelli E, Guidi I, Scalabrini D, Villa C, Kauwe JSK, Mayo K, Valle ED, Lovati C, Mariani C, Scarpini E, Bresolin N, Goate AM, Galimberti D. P3-217: Genetic and functional analysis of progranulin gene variants in patients with Alzheimer's disease Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1784  0.4
2008 Gitcho MA, Strider J, Carter D, Taylor-Reinwald L, Forman MS, Morris JC, Goate AM, Cairns NJ. P2-185: FTLD-U–linked missense mutations in VCP/p97 alter localization of endogenous TDP-43 and induce cell death Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1259  0.36
2008 Kosicek M, Goate A, Hecimovic S. P1-444: Increased formation of amyloid-β peptide in CHO NPC1-null cells does not involve lipid rafts Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1026  0.64
2008 Malnar M, Kosicek M, Goate A, Hecimovic S. P1-443: Increased Aβ formation in CHO NPC1-null cells is not directly related to cholesterol levels Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1025  0.64
2007 Hu Y, Hosseini A, Kauwe JS, Gross J, Cairns NJ, Goate AM, Fagan AM, Townsend RR, Holtzman DM. Identification and validation of novel CSF biomarkers for early stages of Alzheimer's disease. Proteomics. Clinical Applications. 1: 1373-84. PMID 21136637 DOI: 10.1002/Prca.200600999  1
2007 Dick DM, Wang JC, Plunkett J, Aliev F, Hinrichs A, Bertelsen S, Budde JP, Goldstein EL, Kaplan D, Edenberg HJ, Nurnberger J, Hesselbrock V, Schuckit M, Kuperman S, Tischfield J, ... ... Goate A, et al. Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1. Alcoholism, Clinical and Experimental Research. 31: 1645-53. PMID 17850642 DOI: 10.1111/J.1530-0277.2007.00470.X  1
2007 Hamshere ML, Holmans PA, Avramopoulos D, Bassett SS, Blacker D, Bertram L, Wiener H, Rochberg N, Tanzi RE, Myers A, Wavrant-De Vrièze F, Go R, Fallin D, Lovestone S, Hardy J, ... Goate A, et al. Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease. Human Molecular Genetics. 16: 2703-12. PMID 17725986 DOI: 10.1093/Hmg/Ddm224  1
2007 Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, Marky A, Lenting PJ, Wu Z, Zarcone T, Goate A, Mayo K, Perlmutter D, Coma M, Zhong Z, et al. Clearance of amyloid-beta by circulating lipoprotein receptors. Nature Medicine. 13: 1029-31. PMID 17694066 DOI: 10.1038/Nm1635  1
2007 Cairns NJ, Neumann M, Bigio EH, Holm IE, Troost D, Hatanpaa KJ, Foong C, White CL, Schneider JA, Kretzschmar HA, Carter D, Taylor-Reinwald L, Paulsmeyer K, Strider J, Gitcho M, ... Goate AM, et al. TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions. The American Journal of Pathology. 171: 227-40. PMID 17591968 DOI: 10.2353/Ajpath.2007.070182  1
2007 Dick DM, Agrawal A, Wang JC, Hinrichs A, Bertelsen S, Bucholz KK, Schuckit M, Kramer J, Nurnberger J, Tischfield J, Edenberg HJ, Goate A, Bierut LJ. Alcohol dependence with comorbid drug dependence: genetic and phenotypic associations suggest a more severe form of the disorder with stronger genetic contribution to risk. Addiction (Abingdon, England). 102: 1131-9. PMID 17567401 DOI: 10.1111/J.1360-0443.2007.01871.X  0.32
2007 Hollingworth P, Hamshere ML, Holmans PA, O'Donovan MC, Sims R, Powell J, Lovestone S, Myers A, DeVrieze FW, Hardy J, Goate A, Owen M, Williams J. Increased familial risk and genomewide significant linkage for Alzheimer's disease with psychosis. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 144: 841-8. PMID 17492769 DOI: 10.1002/Ajmg.B.30515  1
2007 Nowotny P, Bertelsen S, Hinrichs AL, Kauwe JS, Mayo K, Jacquart S, Morris JC, Goate A. Association studies between common variants in prolyl isomerase Pin1 and the risk for late-onset Alzheimer's disease. Neuroscience Letters. 419: 15-7. PMID 17482359 DOI: 10.1016/J.Neulet.2007.03.071  0.64
2007 Saccone SF, Pergadia ML, Loukola A, Broms U, Montgomery GW, Wang JC, Agrawal A, Dick DM, Heath AC, Todorov AA, Maunu H, Heikkila K, Morley KI, Rice JP, Todd RD, ... ... Goate AM, et al. Genetic linkage to chromosome 22q12 for a heavy-smoking quantitative trait in two independent samples. American Journal of Human Genetics. 80: 856-66. PMID 17436240 DOI: 10.1086/513703  1
2007 Wahrle SE, Shah AR, Fagan AM, Smemo S, Kauwe JS, Grupe A, Hinrichs A, Mayo K, Jiang H, Thal LJ, Goate AM, Holtzman DM. Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1 polymorphisms. Molecular Neurodegeneration. 2: 7. PMID 17430597 DOI: 10.1186/1750-1326-2-7  1
2007 Nowotny P, Simcock X, Bertelsen S, Hinrichs AL, Kauwe JS, Mayo K, Smemo S, Morris JC, Goate A. Association studies testing for risk for late-onset Alzheimer's disease with common variants in the beta-amyloid precursor protein (APP). American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 144: 469-74. PMID 17427190 DOI: 10.1002/Ajmg.B.30485  1
2007 Schymick JC, Yang Y, Andersen PM, Vonsattel JP, Greenway M, Momeni P, Elder J, Chiò A, Restagno G, Robberecht W, Dahlberg C, Mukherjee O, Goate A, Graff-Radford N, Caselli RJ, et al. Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes. Journal of Neurology, Neurosurgery, and Psychiatry. 78: 754-6. PMID 17371905 DOI: 10.1136/Jnnp.2006.109553  1
2007 Kauwe JS, Jacquart S, Chakraverty S, Wang J, Mayo K, Fagan AM, Holtzman DM, Morris JC, Goate AM. Extreme cerebrospinal fluid amyloid beta levels identify family with late-onset Alzheimer's disease presenilin 1 mutation. Annals of Neurology. 61: 446-53. PMID 17366635 DOI: 10.1002/Ana.21099  1
2007 Behrens MI, Mukherjee O, Tu PH, Liscic RM, Grinberg LT, Carter D, Paulsmeyer K, Taylor-Reinwald L, Gitcho M, Norton JB, Chakraverty S, Goate AM, Morris JC, Cairns NJ. Neuropathologic heterogeneity in HDDD1: a familial frontotemporal lobar degeneration with ubiquitin-positive inclusions and progranulin mutation. Alzheimer Disease and Associated Disorders. 21: 1-7. PMID 17334266 DOI: 10.1097/Wad.0B013E31803083F2  1
2007 Grupe A, Abraham R, Li Y, Rowland C, Hollingworth P, Morgan A, Jehu L, Segurado R, Stone D, Schadt E, Karnoub M, Nowotny P, Tacey K, Catanese J, Sninsky J, ... ... Goate A, et al. Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants. Human Molecular Genetics. 16: 865-73. PMID 17317784 DOI: 10.1093/Hmg/Ddm031  1
2007 Mukherjee O, Kauwe JS, Mayo K, Morris JC, Goate AM. Haplotype-based association analysis of the MAPT locus in late onset Alzheimer's disease. Bmc Genetics. 8: 3. PMID 17266761 DOI: 10.1186/1471-2156-8-3  1
2007 Wang JC, Hinrichs AL, Bertelsen S, Stock H, Budde JP, Dick DM, Bucholz KK, Rice J, Saccone N, Edenberg HJ, Hesselbrock V, Kuperman S, Schuckit MA, Bierut LJ, Goate AM. Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin. Alcoholism, Clinical and Experimental Research. 31: 209-15. PMID 17250611 DOI: 10.1111/J.1530-0277.2006.00297.X  1
2007 Dick DM, Aliev F, Kramer J, Wang JC, Hinrichs A, Bertelsen S, Kuperman S, Schuckit M, Nurnberger J, Edenberg HJ, Porjesz B, Begleiter H, Hesselbrock V, Goate A, Bierut L. Association of CHRM2 with IQ: converging evidence for a gene influencing intelligence. Behavior Genetics. 37: 265-72. PMID 17160701 DOI: 10.1007/S10519-006-9131-2  0.32
2007 Bierut LJ, Madden PA, Breslau N, Johnson EO, Hatsukami D, Pomerleau OF, Swan GE, Rutter J, Bertelsen S, Fox L, Fugman D, Goate AM, Hinrichs AL, Konvicka K, Martin NG, et al. Novel genes identified in a high-density genome wide association study for nicotine dependence. Human Molecular Genetics. 16: 24-35. PMID 17158188 DOI: 10.1093/Hmg/Ddl441  1
2007 Saccone SF, Hinrichs AL, Saccone NL, Chase GA, Konvicka K, Madden PA, Breslau N, Johnson EO, Hatsukami D, Pomerleau O, Swan GE, Goate AM, Rutter J, Bertelsen S, Fox L, et al. Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Human Molecular Genetics. 16: 36-49. PMID 17135278 DOI: 10.1093/Hmg/Ddl438  1
2006 Mukherjee O, Pastor P, Cairns NJ, Chakraverty S, Kauwe JS, Shears S, Behrens MI, Budde J, Hinrichs AL, Norton J, Levitch D, Taylor-Reinwald L, Gitcho M, Tu PH, Tenenholz Grinberg L, ... ... Goate AM, et al. HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin. Annals of Neurology. 60: 314-22. PMID 16983685 DOI: 10.1002/Ana.20963  1
2006 Li Y, Grupe A, Rowland C, Nowotny P, Kauwe JS, Smemo S, Hinrichs A, Tacey K, Toombs TA, Kwok S, Catanese J, White TJ, Maxwell TJ, Hollingworth P, Abraham R, ... ... Goate A, et al. DAPK1 variants are associated with Alzheimer's disease and allele-specific expression. Human Molecular Genetics. 15: 2560-8. PMID 16847012 DOI: 10.1093/Hmg/Ddl178  1
2006 Jones KA, Porjesz B, Almasy L, Bierut L, Dick D, Goate A, Hinrichs A, Rice JP, Wang JC, Bauer LO, Crowe R, Foroud T, Hesselbrock V, Kuperman S, Nurnberger J, et al. A cholinergic receptor gene (CHRM2) affects event-related oscillations. Behavior Genetics. 36: 627-39. PMID 16823639 DOI: 10.1007/S10519-006-9075-6  1
2006 Walker ES, Martinez M, Wang J, Goate A. Conserved residues in juxtamembrane region of the extracellular domain of nicastrin are essential for gamma-secretase complex formation. Journal of Neurochemistry. 98: 300-9. PMID 16805816 DOI: 10.1111/J.1471-4159.2006.03881.X  1
2006 Dick DM, Plunkett J, Wetherill LF, Xuei X, Goate A, Hesselbrock V, Schuckit M, Crowe R, Edenberg HJ, Foroud T. Association between GABRA1 and drinking behaviors in the Collaborative Study on the Genetics of Alcoholism sample Alcoholism: Clinical and Experimental Research. 30: 1101-1110. PMID 16792556 DOI: 10.1111/J.1530-0277.2006.00136.X  1
2006 Hinrichs AL, Wang JC, Bufe B, Kwon JM, Budde J, Allen R, Bertelsen S, Evans W, Dick D, Rice J, Foroud T, Nurnberger J, Tischfield JA, Kuperman S, Crowe R, ... ... Goate AM, et al. Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence. American Journal of Human Genetics. 78: 103-11. PMID 16385453 DOI: 10.1086/499253  1
2006 Dick DM, Aliev F, Bierut L, Goate A, Rice J, Hinrichs A, Bertelsen S, Wang JC, Dunn G, Kuperman S, Schuckit M, Nurnberger J, Porjesz B, Beglieter H, Kramer J, et al. Linkage analyses of IQ in the collaborative study on the genetics of alcoholism (COGA) sample. Behavior Genetics. 36: 77-86. PMID 16341907 DOI: 10.1007/S10519-005-9009-8  0.32
2006 Wang J, Beher D, Nyborg AC, Shearman MS, Golde TE, Goate A. C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation. Journal of Neurochemistry. 96: 218-27. PMID 16305624 DOI: 10.1111/J.1471-4159.2005.03548.X  1
2006 Smemo S, Nowotny P, Hinrichs AL, Kauwe JS, Cherny S, Erickson K, Myers AJ, Kaleem M, Marlowe L, Gibson AM, Hollingworth P, O'Donovan MC, Morris CM, Holmans P, Lovestone S, ... ... Goate A, et al. Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease. Annals of Neurology. 59: 21-6. PMID 16278862 DOI: 10.1002/Ana.20673  1
2006 Grupe A, Li Y, Rowland C, Hinrichs T, Holmans P, Hardy J, O'Donovan M, Owen MJ, Williams J, Goate A. Reply to Bertram et al. [2] American Journal of Human Genetics. 79: 183-184. DOI: 10.1086/505033  1
2006 Wang J, Grupe A, Li Y, Nowotny P, Goate A. P1-299: Sorbs 1, a candidate gene for the chromosome 10 late onset Alzheimer’s disease locus Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.676  0.64
2006 Li Y, Grupe A, Rowland C, Nowotny P, Kauwe JSK, Smemo S, Hinrichs A, Tacey K, Kwok S, Catanese J, Sninsky J, White TJ, Hollingworth P, Harris SL, Levine A, ... ... Goate A, et al. O2-02-07 Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.117  0.64
2006 Goate A. Segregation of a missense mutation in the amyloid β-protein precursor gene with familial Alzheimer’s disease Journal of Alzheimer's Disease. 9: 157-161. DOI: 10.1007/978-3-540-37652-1_16  0.64
2005 Snider BJ, Norton J, Coats MA, Chakraverty S, Hou CE, Jervis R, Lendon CL, Goate AM, McKeel DW, Morris JC. Novel presenilin 1 mutation (S170F) causing Alzheimer disease with Lewy bodies in the third decade of life. Archives of Neurology. 62: 1821-30. PMID 16344340 DOI: 10.1001/Archneur.62.12.1821  1
2005 Brunkan AL, Martinez M, Wang J, Walker ES, Beher D, Shearman MS, Goate AM. Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and gamma-secretase activity. Journal of Neurochemistry. 94: 1315-28. PMID 16001967 DOI: 10.1111/J.1471-4159.2005.03278.X  1
2005 Li Y, Rowland C, Tacey K, Catanese J, Sninsky J, Hardy J, Powell J, Lovestone S, Morris JC, Thal L, Goate A, Owen M, Williams J, Grupe A. The BDNF Val66Met polymorphism is not associated with late onset Alzheimer's disease in three case-control samples. Molecular Psychiatry. 10: 809-10. PMID 15970929 DOI: 10.1038/Sj.Mp.4001702  1
2005 Brunkan AL, Martinez M, Walker ES, Goate AM. Presenilin endoproteolysis is an intramolecular cleavage. Molecular and Cellular Neurosciences. 29: 65-73. PMID 15866047 DOI: 10.1016/J.Mcn.2004.12.012  1
2005 Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell T, Holmans P, Hamshere M, Turic D, Jehu L, Hollingworth P, Moore P, Bryden L, Myers A, Doil LM, Tacey KM, ... ... Goate A, et al. Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 136: 62-8. PMID 15858813 DOI: 10.1002/Ajmg.B.30186  1
2005 Brunkan AL, Goate AM. Presenilin function and gamma-secretase activity. Journal of Neurochemistry. 93: 769-92. PMID 15857382 DOI: 10.1111/J.1471-4159.2005.03099.X  1
2005 Holmans P, Hamshere M, Hollingworth P, Rice F, Tunstall N, Jones S, Moore P, Wavrant DeVrieze F, Myers A, Crook R, Compton D, Marshall H, Meyer D, Shears S, Booth J, ... ... Goate A, et al. Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 135: 24-32. PMID 15729734 DOI: 10.1002/Ajmg.B.30114  1
2005 Brunkan AL, Martinez M, Wang J, Walker ES, Goate AM. A domain at the C-terminus of PS1 is required for presenilinase and gamma-secretase activities. Journal of Neurochemistry. 92: 1158-69. PMID 15715666 DOI: 10.1111/J.1471-4159.2004.02945.X  1
2005 Li Y, Hollingworth P, Moore P, Foy C, Archer N, Powell J, Nowotny P, Holmans P, O'Donovan M, Tacey K, Doil L, van Luchene R, Garcia V, Rowland C, Lau K, ... ... Goate A, et al. Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease. Human Mutation. 25: 270-7. PMID 15714520 DOI: 10.1002/Humu.20138  1
2005 Dick DM, Edenberg HJ, Xuei X, Goate A, Hesselbrock V, Schuckit M, Crowe R, Foroud T. No association of the GABAA receptor genes on chromosome 5 with alcoholism in the collaborative study on the genetics of alcoholism sample American Journal of Medical Genetics - Neuropsychiatric Genetics. 132: 24-28. PMID 15690551 DOI: 10.1002/Ajmg.B.30058  1
2005 Walker ES, Martinez M, Brunkan AL, Goate A. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios. Journal of Neurochemistry. 92: 294-301. PMID 15663477 DOI: 10.1111/J.1471-4159.2004.02858.X  1
2004 Hecimovic S, Wang J, Dolios G, Martinez M, Wang R, Goate AM. Mutations in APP have independent effects on Abeta and CTFgamma generation. Neurobiology of Disease. 17: 205-18. PMID 15474359 DOI: 10.1016/J.Nbd.2004.04.018  1
2004 Pastor P, Ezquerra M, Perez JC, Chakraverty S, Norton J, Racette BA, McKeel D, Perlmutter JS, Tolosa E, Goate AM. Novel haplotypes in 17q21 are associated with progressive supranuclear palsy. Annals of Neurology. 56: 249-58. PMID 15293277 DOI: 10.1002/Ana.20178  1
2004 Li Y, Tacey K, Doil L, van Luchene R, Garcia V, Rowland C, Schrodi S, Leong D, Lau K, Catanese J, Sninsky J, Nowotny P, Holmans P, Hardy J, Powell J, ... ... Goate A, et al. Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study. Neuroscience Letters. 366: 268-71. PMID 15288432 DOI: 10.1016/J.Neulet.2004.05.047  1
2004 Wang JC, Hinrichs AL, Stock H, Budde J, Allen R, Bertelsen S, Kwon JM, Wu W, Dick DM, Rice J, Jones K, Nurnberger JI, Tischfield J, Porjesz B, Edenberg HJ, ... ... Goate AM, et al. Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome. Human Molecular Genetics. 13: 1903-11. PMID 15229186 DOI: 10.1093/Hmg/Ddh194  1
2004 Jones KA, Porjesz B, Almasy L, Bierut L, Goate A, Wang JC, Dick DM, Hinrichs A, Kwon J, Rice JP, Rohrbaugh J, Stock H, Wu W, Bauer LO, Chorlian DB, et al. Linkage and linkage disequilibrium of evoked EEG oscillations with CHRM2 receptor gene polymorphisms: implications for human brain dynamics and cognition. International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology. 53: 75-90. PMID 15210286 DOI: 10.1016/J.Ijpsycho.2004.02.004  1
2004 Johnson J, Ostojic J, Lannfelt L, Glaser A, Basun H, Rogaeva E, Kawarai T, Bruni A, St George Hyslop PH, Goate A, Pastor P, Chakraverty S, Norton J, Morris JC, Hardy J, et al. No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found. Neuroscience Letters. 363: 99-101. PMID 15172093 DOI: 10.1016/J.Neulet.2004.03.070  1
2004 Busby V, Goossens S, Nowotny P, Hamilton G, Smemo S, Harold D, Turic D, Jehu L, Myers A, Womick M, Woo D, Compton D, Doil LM, Tacey KM, Lau KF, ... ... Goate A, et al. Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease. Neuromolecular Medicine. 5: 133-46. PMID 15075440 DOI: 10.1385/Nmm:5:2:133  1
2004 Wang J, Brunkan AL, Hecimovic S, Walker E, Goate A. Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes. Neurobiology of Disease. 15: 654-66. PMID 15056474 DOI: 10.1016/J.Nbd.2003.12.008  1
2004 Pastor P, Goate AM. Molecular genetics of Alzheimer's disease. Current Psychiatry Reports. 6: 125-33. PMID 15038915 DOI: 10.1007/S11920-004-0052-6  1
2004 Edenberg HJ, Dick DM, Xuei X, Tian H, Almasy L, Bauer LO, Crowe RR, Goate A, Hesselbrock V, Jones K, Kwon J, Li TK, Nurnberger JI, O'Connor SJ, Reich T, et al. Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. American Journal of Human Genetics. 74: 705-14. PMID 15024690 DOI: 10.1086/383283  1
2004 Myers AJ, Marshall H, Holmans P, Compton D, Crook RJ, Mander AP, Nowotny P, Smemo S, Dunstan M, Jehu L, Wang JC, Hamshere M, Morris JC, Norton J, Chakraventy S, ... ... Goate A, et al. Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 124: 29-37. PMID 14681909 DOI: 10.1002/Ajmg.B.20036  1
2004 Bierut LJ, Rice JP, Goate A, Hinrichs AL, Saccone NL, Foroud T, Edenberg HJ, Cloninger CR, Begleiter H, Conneally PM, Crowe RR, Hesselbrock V, Li TK, Nurnberger JI, Porjesz B, et al. A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependence. American Journal of Medical Genetics. Part A. 124: 19-27. PMID 14679582 DOI: 10.1002/Ajmg.A.20329  1
2004 Wang J, Beher D, Shearman MS, Goate A. P4-286 The C-terminal PAL motif in presenilins constitutes part of the gamma-secretase active site pocket Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81844-X  0.64
2004 Li Y, Hollingworth P, Moore P, Foy C, Archer N, Nowotny P, Holmans P, Smemo S, Tacey K, Doil L, Luchene Rv, Lau K, Catanese J, Garcia V, Rowland C, ... ... Goate A, et al. P4-122 Genetic association of an APP binding protein gene with late onset Alzheimer's disease Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81680-4  0.64
2004 Doil L, Tacey K, Nowotny P, Luchene Rv, Li Y, Holmans P, Smemo S, Garcia V, Rowland C, Leong D, Gogic G, Cravchik A, Ross D, Lau K, Catanese J, ... ... Goate A, et al. P4-110 A systematic scan of chromosome 10 single nucleotide polymorphisms identifies novel candidate genes showing strong association to Alzheimer's disease Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81668-3  0.64
2004 Dunstan ML, Jehu L, Jones S, Hollingworth P, Moore P, Lovestone S, Nowotny P, Goate A, O'Donovan M, Owen MJ, Jones L, Williams J. P4-106 Evidence for association of the calcium/calmodulin-dependent protein kinase type II gamma isoform (CAMKII γ) with late onset Alzheimer's disease Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81664-6  0.88
2004 Lau KF, Rowland C, Tacey K, Doil L, Li Y, Luchene Rv, Nowotny P, Smemo S, Garcia V, Lovestone S, Owen M, Williams J, Grupe A, Goate A. P4-067 Genetic association studies of insulin-degrading enzyme (IDE) with late onset Alzheimer's disease (LOAD) - Equivocal results from two large case-control studies Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81625-7  0.64
2004 Li Y, Nowotny P, Holmans P, Smemo S, Kawe K, Tacey K, Doil L, Luchene Rv, Garcia V, Rowland C, Schrodi S, Leong D, Chan J, Lau K, Chang S, ... ... Goate A, et al. P4-046 Association of late onset Alzheimer's disease with genetic variation in multiple members of a gene family involved in neuronal apoptosis Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81604-X  0.64
2003 McInnis MG, Dick DM, Willour VL, Avramopoulos D, MacKinnon DF, Simpson SG, Potash JB, Edenberg HJ, Bowman ES, McMahon FJ, Smiley C, Chellis JL, Huo Y, Diggs T, Meyer ET, ... ... Goate AM, et al. Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigrees. Biological Psychiatry. 54: 1265-73. PMID 14643094 DOI: 10.1016/J.Biopsych.2003.08.001  1
2003 Schroeter EH, Ilagan MX, Brunkan AL, Hecimovic S, Li YM, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Goate A, Wolfe MS, et al. A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proceedings of the National Academy of Sciences of the United States of America. 100: 13075-80. PMID 14566063 DOI: 10.1073/Pnas.1735338100  1
2003 Pastor P, Roe CM, Villegas A, Bedoya G, Chakraverty S, García G, Tirado V, Norton J, Ríos S, Martínez M, Kosik KS, Lopera F, Goate AM. Apolipoprotein Eepsilon4 modifies Alzheimer's disease onset in an E280A PS1 kindred. Annals of Neurology. 54: 163-9. PMID 12891668 DOI: 10.1002/Ana.10636  1
2003 Segurado R, Detera-Wadleigh SD, Levinson DF, Lewis CM, Gill M, Nurnberger JI, Craddock N, DePaulo JR, Baron M, Gershon ES, Ekholm J, Cichon S, Turecki G, Claes S, Kelsoe JR, ... ... Goate A, et al. Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder. American Journal of Human Genetics. 73: 49-62. PMID 12802785 DOI: 10.1086/376547  1
2003 Harold D, Peirce T, Moskvina V, Myers A, Jones S, Hollingworth P, Moore P, Lovestone S, Powell J, Foy C, Archer N, Walter S, Edmonson A, McIlroy S, Craig D, ... ... Goate A, et al. Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease. Human Genetics. 113: 258-67. PMID 12759818 DOI: 10.1007/S00439-003-0960-2  1
2003 Zhukareva V, Sundarraj S, Mann D, Sjogren M, Blenow K, Clark CM, McKeel DW, Goate A, Lippa CF, Vonsattel JP, Growdon JH, Trojanowski JQ, Lee VM. Selective reduction of soluble tau proteins in sporadic and familial frontotemporal dementias: an international follow-up study. Acta Neuropathologica. 105: 469-76. PMID 12677447 DOI: 10.1007/S00401-002-0668-8  1
2003 Ghosh S, Begleiter H, Porjesz B, Chorlian DB, Edenberg HJ, Foroud T, Goate A, Reich T. Linkage mapping of Beta 2 EEG waves via non-parametric regression American Journal of Medical Genetics - Neuropsychiatric Genetics. 118: 66-71. PMID 12627469 DOI: 10.1002/Ajmg.B.10057  1
2002 Dick DM, Nurnberger J, Edenberg HJ, Goate A, Crowe R, Rice J, Bucholz KK, Kramer J, Schuckit MA, Smith TL, Porjesz B, Begleiter H, Hesselbrock V, Foroud T. Suggestive linkage on chromosome 1 for a quantitative alcohol-related phenotype. Alcoholism, Clinical and Experimental Research. 26: 1453-60. PMID 12394277 DOI: 10.1111/J.1530-0277.2002.Tb02443.X  1
2002 Porjesz B, Begleiter H, Wang K, Almasy L, Chorlian DB, Stimus AT, Kuperman S, O'Connor SJ, Rohrbaugh J, Bauer LO, Edenberg HJ, Goate A, Rice JP, Reich T. Linkage and linkage disequilibrium mapping of ERP and EEG phenotypes. Biological Psychology. 61: 229-48. PMID 12385677 DOI: 10.1016/S0301-0511(02)00060-1  1
2002 Lambert JC, Araria-Goumidi L, Myllykangas L, Ellis C, Wang JC, Bullido MJ, Harris JM, Artiga MJ, Hernandez D, Kwon JM, Frigard B, Petersen RC, Cumming AM, Pasquier F, Sastre I, ... ... Goate AM, et al. Contribution of APOE promoter polymorphisms to Alzheimer's disease risk. Neurology. 59: 59-66. PMID 12105308 DOI: 10.1212/Wnl.59.1.59  1
2002 Zhou Y, Zhang W, Easton R, Ray JW, Lampe P, Jiang Z, Brunkan AL, Goate A, Johnson EM, Wu JY. Presenilin-1 protects against neuronal apoptosis caused by its interacting protein PAG. Neurobiology of Disease. 9: 126-38. PMID 11895366 DOI: 10.1006/Nbdi.2001.0472  1
2002 Porjesz B, Almasy L, Edenberg HJ, Wang K, Chorlian DB, Foroud T, Goate A, Rice JP, O'Connor SJ, Rohrbaugh J, Kuperman S, Bauer LO, Crowe RR, Schuckit MA, Hesselbrock V, et al. Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus. Proceedings of the National Academy of Sciences of the United States of America. 99: 3729-33. PMID 11891318 DOI: 10.1073/Pnas.052716399  1
2002 Racette BA, Rundle M, Wang JC, Goate A, Saccone NL, Farrer M, Lincoln S, Hussey J, Smemo S, Lin J, Suarez B, Parsian A, Perlmutter JS. A multi-incident, Old-Order Amish family with PD. Neurology. 58: 568-74. PMID 11865134 DOI: 10.1212/Wnl.58.4.568  1
2002 Myers A, Wavrant De-Vrieze F, Holmans P, Hamshere M, Crook R, Compton D, Marshall H, Meyer D, Shears S, Booth J, Ramic D, Knowles H, Morris JC, Williams N, Norton N, ... ... Goate A, et al. Full genome screen for Alzheimer disease: stage II analysis. American Journal of Medical Genetics. 114: 235-44. PMID 11857588 DOI: 10.1002/Ajmg.10183  1
2002 Kopan R, Goate A. Aph-2/Nicastrin: an essential component of gamma-secretase and regulator of Notch signaling and Presenilin localization. Neuron. 33: 321-4. PMID 11832221 DOI: 10.1016/S0896-6273(02)00585-8  1
2001 Abraham R, Myers A, Wavrant-DeVrieze F, Hamshere ML, Thomas HV, Marshall H, Compton D, Spurlock G, Turic D, Hoogendoorn B, Kwon JM, Petersen RC, Tangalos E, Norton J, Morris JC, ... ... Goate A, et al. Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease. Human Genetics. 109: 646-52. PMID 11810277 DOI: 10.1007/S00439-001-0614-1  1
2001 Nowotny P, Kwon JM, Goate AM. SNP analysis to dissect human traits. Current Opinion in Neurobiology. 11: 637-41. PMID 11595500 DOI: 10.1016/S0959-4388(00)00261-0  1
2001 Myers AJ, Goate AM. The genetics of late-onset Alzheimer's disease. Current Opinion in Neurology. 14: 433-40. PMID 11470958 DOI: 10.1097/00019052-200108000-00002  1
2001 Nowotny P, Kwon JM, Chakraverty S, Nowotny V, Morris JC, Goate AM. Association studies using novel polymorphisms in BACE1 and BACE2. Neuroreport. 12: 1799-802. PMID 11435901 DOI: 10.1097/00001756-200107030-00008  1
2001 Nurnberger JI, Foroud T, Flury L, Su J, Meyer ET, Hu K, Crowe R, Edenberg H, Goate A, Bierut L, Reich T, Schuckit M, Reich W. Evidence for a locus on chromosome 1 that influences vulnerability to alcoholism and affective disorder American Journal of Psychiatry. 158: 718-724. PMID 11329392 DOI: 10.1176/Appi.Ajp.158.5.718  1
2001 Schuckit MA, Edenberg HJ, Kalmijn J, Flury L, Smith TL, Reich T, Bierut L, Goate A, Foroud T. A genome-wide search for genes that relate to a low level of response to alcohol. Alcoholism, Clinical and Experimental Research. 25: 323-9. PMID 11290841 DOI: 10.1111/J.1530-0277.2001.Tb02217.X  1
2001 Almasy L, Porjesz B, Blangero J, Goate A, Edenberg HJ, Chorlian DB, Kuperman S, O'Connor SJ, Rohrbaugh J, Bauer LO, Foroud T, Rice JP, Reich T, Begleiter H. Genetics of event-related brain potentials in response to a semantic priming paradigm in families with a history of alcoholism. American Journal of Human Genetics. 68: 128-135. PMID 11102287 DOI: 10.1086/316936  1
2001 Wu WS, Goate A, Meyer D, Kwon J, Hinrichs A, Reich T, Bierut L, Saccone N, Rice J, Li TK, Hesselbrock V, Crowe R, Schuckit M, Begleiter H, Goate AM. Analysis of variation in the protein kinase C-epsilon gene in the COGA study American Journal of Medical Genetics - Neuropsychiatric Genetics. 105: 629.  1
2001 Kwon JM, Wu W, Meyers D, Stock H, Hinrichs AL, Miller R, Goate AM. Candidate gene analysis of alcoholism and related phenotypes American Journal of Medical Genetics - Neuropsychiatric Genetics. 105: 567.  1
2000 Ardila A, Lopera F, Rosselli M, Moreno S, Madrigal L, Arango-Lasprilla JC, Arcos M, Murcia C, Arango-Viana JC, Ossa J, Goate A, Kosik KS. Neuropsychological profile of a large kindred with familial Alzheimer's disease caused by the E280A single presenilin-1 mutation. Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists. 15: 515-28. PMID 14590205 DOI: 10.1093/Arclin/15.6.515  1
2000 Kwon JM, Goate AM. The candidate gene approach. Alcohol Research & Health : the Journal of the National Institute On Alcohol Abuse and Alcoholism. 24: 164-8. PMID 11199286  1
2000 Myers A, Holmans P, Marshall H, Kwon J, Meyer D, Ramic D, Shears S, Booth J, DeVrieze FW, Crook R, Hamshere M, Abraham R, Tunstall N, Rice F, Carty S, ... ... Goate AM, et al. Susceptibility locus for Alzheimer's disease on chromosome 10. Science (New York, N.Y.). 290: 2304-5. PMID 11125144 DOI: 10.1126/Science.290.5500.2304  1
2000 Kopan R, Goate A. A common enzyme connects notch signaling and Alzheimer's disease. Genes & Development. 14: 2799-806. PMID 11090127 DOI: 10.1101/Gad.836900  1
2000 Saccone NL, Kwon JM, Corbett J, Goate A, Rochberg N, Edenberg HJ, Foroud T, Li TK, Begleiter H, Reich T, Rice JP. A genome screen of maximum number of drinks as an alcoholism phenotype American Journal of Medical Genetics - Neuropsychiatric Genetics. 96: 632-637. PMID 11054770 DOI: 10.1002/1096-8628(20001009)96:5<632::Aid-Ajmg8>3.0.Co;2-#  1
2000 Rosselli MC, Ardila AC, Moreno SC, Standish VC, Arango-Lasprilla JC, Tirado VM, Ossa JM, Goate AM, Kosik KS, Lopera F. Cognitive decline in patients with familial Alzheimer's disease associated with E280a presenilin-1 mutation: a longitudinal study. Journal of Clinical and Experimental Neuropsychology. 22: 483-95. PMID 10923058 DOI: 10.1076/1380-3395(200008)22:4;1-0;Ft483  1
2000 Xia W, Ray WJ, Ostaszewski BL, Rahmati T, Kimberly WT, Wolfe MS, Zhang J, Goate AM, Selkoe DJ. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation. Proceedings of the National Academy of Sciences of the United States of America. 97: 9299-304. PMID 10922078 DOI: 10.1073/Pnas.97.16.9299  1
2000 Jiang Z, Cote J, Kwon JM, Goate AM, Wu JY. Aberrant splicing of tau pre-mRNA caused by intronic mutations associated with the inherited dementia frontotemporal dementia with parkinsonism linked to chromosome 17. Molecular and Cellular Biology. 20: 4036-48. PMID 10805746 DOI: 10.1128/Mcb.20.11.4036-4048.2000  1
2000 Kwon JM, Nowotny P, Shah PK, Chakraverty S, Norton J, Morris JC, Goate AM. Tau polymorphisms are not associated with Alzheimer's disease. Neuroscience Letters. 284: 77-80. PMID 10771166 DOI: 10.1016/S0304-3940(00)00972-1  1
2000 Bierut LJ, Rice JP, Edenberg HJ, Goate A, Foroud T, Cloninger CR, Begleiter H, Conneally PM, Crowe RR, Hesselbrock V, Li TK, Nurnberger JI, Porjesz B, Schuckit MA, Reich T. Family-based study of the association of the dopamine D2 receptor gene (DRD2) with habitual smoking. American Journal of Medical Genetics. 90: 299-302. PMID 10710227 DOI: 10.1002/(Sici)1096-8628(20000214)90:4<299::Aid-Ajmg7>3.0.Co;2-Y  1
2000 Foroud T, Castelluccio PF, Koller DL, Edenberg HJ, Miller M, Bowman E, Rau NL, Smiley C, Rice JP, Goate A, Armstrong C, Bierut LJ, Reich T, Detera-Wadleigh SD, Goldin LR, et al. Suggestive evidence of a locus on chromosome 10p using the NIMH genetics initiative bipolar affective disorder pedigrees. American Journal of Medical Genetics. 96: 18-23. PMID 10686547 DOI: 10.1002/(Sici)1096-8628(20000207)96:1<18::Aid-Ajmg6>3.0.Co;2-G  1
2000 Nowotny P, Gorski SM, Han SW, Philips K, Ray WJ, Nowotny V, Jones CJ, Clark RF, Cagan RL, Goate AM. Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin. Molecular and Cellular Neurosciences. 15: 88-98. PMID 10662508 DOI: 10.1006/Mcne.1999.0805  1
2000 Ray WJ, Goate AM. 34. The genetics of Alzheimer's disease Facts, Research and Intervention in Geriatrics. 2000: 441-451.  1
1999 Begleiter H, Reich T, Nurnberger J, Li TK, Conneally PM, Edenberg H, Crowe R, Kuperman S, Schuckit M, Bloom F, Hesselbrock V, Porjesz B, Cloninger CR, Rice J, Goate A. Description of the Genetic Analysis Workshop 11 Collaborative Study on the Genetics of Alcoholism. Genetic Epidemiology. 17: S25-30. PMID 10597407 DOI: 10.1002/Gepi.1370170705  1
1999 Ray WJ, Yao M, Mumm J, Schroeter EH, Saftig P, Wolfe M, Selkoe DJ, Kopan R, Goate AM. Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch. The Journal of Biological Chemistry. 274: 36801-7. PMID 10593990 DOI: 10.1074/Jbc.274.51.36801  1
1999 Williams JT, Begleiter H, Porjesz B, Edenberg HJ, Foroud T, Reich T, Goate A, Van Eerdewegh P, Almasy L, Blangero J. Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. II. Alcoholism and event-related potentials. American Journal of Human Genetics. 65: 1148-60. PMID 10486334 DOI: 10.1086/302571  1
1999 Froelich S, Houlden H, Rizzu P, Chakraverty S, Baker M, Kwon J, Nowotny P, Isaacs A, Nowotny V, Wauters E, van Baren MJ, Oostra BA, Hardy J, Lannfelt L, Goate A, et al. Construction of a detailed physical and transcript map of the FTDP-17 candidate region on chromosome 17q21. Genomics. 60: 129-36. PMID 10486204 DOI: 10.1006/Geno.1999.5892  1
1999 Wang JC, Radford DM, Holt MS, Helms C, Goate A, Brandt W, Parik M, Phillips NJ, DeSchryver K, Schuh ME, Fair KL, Ritter JH, Marshall P, Donis-Keller H. Sequence-ready contig for the 1.4-cM ductal carcinoma in situ loss of heterozygosity region on chromosome 8p22-p23. Genomics. 60: 1-11. PMID 10458905 DOI: 10.1006/Geno.1999.5905  1
1999 Wavrant-De Vrièze F, Crook R, Holmans P, Kehoe P, Owen MJ, Williams J, Roehl K, Laliiri DK, Shears S, Booth J, Wu W, Goate A, Chartier-Harlin MC, Hardy J, Pérez-Tur J. Genetic variability at the amyloid-beta precursor protein locus may contribute to the risk of late-onset Alzheimer's disease. Neuroscience Letters. 269: 67-70. PMID 10430506 DOI: 10.1016/S0304-3940(99)00417-6  0.88
1999 Rudrasingham V, Wavrant-De Vrièze F, Lambert JC, Chakraverty S, Kehoe P, Crook R, Amouyel P, Wu W, Rice F, Pérez-Tur J, Frigard B, Morris JC, Carty S, Petersen R, Cottel D, ... ... Goate A, et al. Alpha-2 macroglobulin gene and Alzheimer disease. Nature Genetics. 22: 17-9; author reply 2. PMID 10319854 DOI: 10.1038/8726  0.88
1999 De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature. 398: 518-22. PMID 10206645 DOI: 10.1038/19083  1
1999 Wavrant-DeVrièze F, Rudrasingham V, Lambert JC, Chakraverty S, Kehoe P, Crook R, Amouyel P, Wu W, Holmans P, Rice F, Pérez-Tur J, Frigard B, Morris JC, Carty S, Cottel D, ... ... Goate A, et al. No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease. Neuroscience Letters. 262: 137-9. PMID 10203250 DOI: 10.1016/S0304-3940(99)00035-X  0.88
1999 Ray WJ, Yao M, Nowotny P, Mumm J, Zhang W, Wu JY, Kopan R, Goate AM. Evidence for a physical interaction between presenilin and Notch. Proceedings of the National Academy of Sciences of the United States of America. 96: 3263-8. PMID 10077672 DOI: 10.1073/Pnas.96.6.3263  1
1999 Houlden H, Rizzu P, Stevens M, de Knijff P, van Duijn CM, van Swieten JC, Heutink P, Perez-Tur J, Thomas V, Baker M, Morris H, Rossor M, Jannsen JC, Petersen RC, Dodd P, et al. Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations. Neuroscience Letters. 260: 193-5. PMID 10076900 DOI: 10.1016/S0304-3940(98)00931-8  1
1999 Kehoe P, Wavrant-De Vrieze F, Crook R, Wu WS, Holmans P, Fenton I, Spurlock G, Norton N, Williams H, Williams N, Lovestone S, Perez-Tur J, Hutton M, Chartier-Harlin MC, Shears S, ... ... Goate A, et al. A full genome scan for late onset Alzheimer's disease. Human Molecular Genetics. 8: 237-45. PMID 9931331 DOI: 10.1093/Hmg/8.2.237  1
1998 Aronsson FC, Magnusson P, Andersson B, Karsten SL, Shibasaki Y, Lendon CL, Goate AM, Brookes AJ. The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17. Human Genetics. 103: 340-5. PMID 9799091 DOI: 10.1007/S004390050827  1
1998 Goate AM. Monogenetic determinants of Alzheimer's disease: APP mutations. Cellular and Molecular Life Sciences : Cmls. 54: 897-901. PMID 9791531 DOI: 10.1007/S000180050218  1
1998 Wu WS, Holmans P, Wavrant-DeVrièze F, Shears S, Kehoe P, Crook R, Booth J, Williams N, Pérez-Tur J, Roehl K, Fenton I, Chartier-Harlin MC, Lovestone S, Williams J, Hutton M, ... ... Goate A, et al. Genetic studies on chromosome 12 in late-onset Alzheimer disease. Jama. 280: 619-22. PMID 9718053 DOI: 10.1001/Jama.280.7.619  0.88
1998 Hellman NE, Grant EA, Goate AM. Failure to replicate a protective effect of allele 2 of NACP/alpha-synuclein polymorphism in Alzheimer's disease: an association study. Annals of Neurology. 44: 278-81. PMID 9708555 DOI: 10.1002/Ana.410440223  1
1998 Goate AM, Edenberg HJ. The genetics of alcoholism. Current Opinion in Genetics & Development. 8: 282-6. PMID 9691005 DOI: 10.1016/S0959-437X(98)80082-8  1
1998 Cloninger CR, Van Eerdewegh P, Goate A, Edenberg HJ, Blangero J, Hesselbrock V, Reich T, Nurnberger J, Schuckit M, Porjesz B, Crowe R, Rice JP, Foroud T, Przybeck TR, Almasy L, et al. Anxiety proneness linked to epistatic loci in genome scan of human personality traits. American Journal of Medical Genetics. 81: 313-7. PMID 9674977 DOI: 10.1002/(Sici)1096-8628(19980710)81:4<313::Aid-Ajmg7>3.0.Co;2-U  1
1998 Malin SA, Guo WX, Jafari G, Goate AM, Nerbonne JM. Presenilins upregulate functional K+ channel currents in mammalian cells. Neurobiology of Disease. 4: 398-409. PMID 9666479 DOI: 10.1006/Nbdi.1998.0167  1
1998 Hutton M, Lendon CL, Rizzu P, Baker M, Froelich S, Houlden H, Pickering-Brown S, Chakraverty S, Isaacs A, Grover A, Hackett J, Adamson J, Lincoln S, Dickson D, Davies P, ... ... Goate A, et al. Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17. Nature. 393: 702-5. PMID 9641683 DOI: 10.1038/31508  1
1998 Lendon CL, Lynch T, Norton J, McKeel DW, Busfield F, Craddock N, Chakraverty S, Gopalakrishnan G, Shears SD, Grimmett W, Wilhelmsen KC, Hansen L, Morris JC, Goate AM. Hereditary dysphasic disinhibition dementia: a frontotemporal dementia linked to 17q21-22. Neurology. 50: 1546-55. PMID 9633693 DOI: 10.1212/Wnl.50.6.1546  1
1998 Begleiter H, Porjesz B, Reich T, Edenberg HJ, Goate A, Blangero J, Almasy L, Foroud T, Van Eerdewegh P, Polich J, Rohrbaugh J, Kuperman S, Bauer LO, O'Connor SJ, Chorlian DB, et al. Quantitative trait loci analysis of human event-related brain potentials: P3 voltage. Electroencephalography and Clinical Neurophysiology. 108: 244-50. PMID 9607513 DOI: 10.1016/S0168-5597(98)00002-1  1
1998 Reich T, Edenberg HJ, Goate A, Williams JT, Rice JP, Van Eerdewegh P, Foroud T, Hesselbrock V, Schuckit MA, Bucholz K, Porjesz B, Li TK, Conneally PM, Nurnberger JI, Tischfield JA, et al. Genome-wide search for genes affecting the risk for alcohol dependence. American Journal of Medical Genetics. 81: 207-15. PMID 9603606 DOI: 10.1002/(Sici)1096-8628(19980508)81:3<207::Aid-Ajmg1>3.0.Co;2-T  1
1998 Ray WJ, Ashall F, Goate AM. Molecular pathogenesis of sporadic and familial forms of Alzheimer's disease. Molecular Medicine Today. 4: 151-7. PMID 9572056 DOI: 10.1016/S1357-4310(98)01229-5  1
1998 Berg L, McKeel DW, Miller JP, Storandt M, Rubin EH, Morris JC, Baty J, Coats M, Norton J, Goate AM, Price JL, Gearing M, Mirra SS, Saunders AM. Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype. Archives of Neurology. 55: 326-35. PMID 9520006 DOI: 10.1001/Archneur.55.3.326  1
1998 Bullido MJ, Artiga MJ, Recuero M, Sastre I, García MA, Aldudo J, Lendon C, Han SW, Morris JC, Frank A, Vázquez J, Goate A, Valdivieso F. A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia Nature Genetics. 18: 69-71. PMID 9425904 DOI: 10.1038/Ng0198-69  0.64
1998 Zhang W, Han SW, McKeel DW, Goate A, Wu JY. Interaction of Presenilins with the Filamin Family of Actin-Binding Proteins The Journal of Neuroscience. 18: 914-922. DOI: 10.1523/Jneurosci.18-03-00914.1998  0.64
1998 Lendon CL, Lobos E, Bullido MJ, Artiga MJ, Chakraverty S, Morris JC, Valdivieso F, Goate AM. Variation at the apolipoprotein E locus and risk for Alzheimer's disease: Cladistic analysis American Journal of Medical Genetics - Neuropsychiatric Genetics. 81: 554.  1
1998 Todd RD, Ji T, Goate AM. Prediction of APOE genotype by phenotype in Alzheimer's disease American Journal of Medical Genetics - Neuropsychiatric Genetics. 81: 554.  1
1997 Goate AM, Morris JC. Notch3 mutations and the potential for diagnostic testing for CADASIL. Lancet. 350: 1490. PMID 9388391 DOI: 10.1016/S0140-6736(97)22047-7  1
1997 Reed LA, Grabowski TJ, Schmidt ML, Morris JC, Goate A, Solodkin A, Van Hoesen GW, Schelper RL, Talbot CJ, Wragg MA, Trojanowski JQ. Autosomal dominant dementia with widespread neurofibrillary tangles. Annals of Neurology. 42: 564-72. PMID 9382467 DOI: 10.1002/Ana.410420406  1
1997 Goate AM. Molecular genetics of Alzheimer's disease. Geriatrics. 52: S9-12. PMID 9307578  1
1997 Lendon CL, Martinez A, Behrens IM, Kosik KS, Madrigal L, Norton J, Neuman R, Myers A, Busfield F, Wragg M, Arcos M, Arango Viana JC, Ossa J, Ruiz A, Goate AM, et al. E280A PS-1 mutation causes Alzheimer's disease but age of onset is not modified by ApoE alleles. Human Mutation. 10: 186-95. PMID 9298817 DOI: 10.1002/(Sici)1098-1004(1997)10:3<186::Aid-Humu2>3.0.Co;2-H  1
1997 Lendon CL, Myers A, Cumming A, Goate AM, St Clair D. A polymorphism in the presenilin 1 gene does not modify risk for Alzheimer's disease in a cohort with sporadic early onset. Neuroscience Letters. 228: 212-4. PMID 9218645 DOI: 10.1016/S0304-3940(97)00393-5  1
1997 Stine OC, McMahon FJ, Chen L, Xu J, Meyers DA, MacKinnon DF, Simpson S, McInnis MG, Rice JP, Goate A, Reich T, Edenberg HJ, Foroud T, Nurnberger JI, Detera-Wadleigh SD, et al. Initial genome screen for bipolar disorder in the NIMH genetics initiative pedigrees: chromosomes 2, 11, 13, 14, and X. American Journal of Medical Genetics. 74: 263-9. PMID 9184308 DOI: 10.1002/(Sici)1096-8628(19970531)74:3<263::Aid-Ajmg5>3.0.Co;2-R  1
1997 Rice JP, Goate A, Williams JT, Bierut L, Dorr D, Wu W, Shears S, Gopalakrishnan G, Edenberg HJ, Foroud T, Nurnberger J, Gershon ES, Detera-Wadleigh SD, Goldin LR, Guroff JJ, et al. Initial genome scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 1, 6, 8, 10, and 12. American Journal of Medical Genetics. 74: 247-53. PMID 9184306 DOI: 10.1002/(Sici)1096-8628(19970531)74:3<247::Aid-Ajmg3>3.0.Co;2-N  1
1997 Edenberg HJ, Foroud T, Conneally PM, Sorbel JJ, Carr K, Crose C, Willig C, Zhao J, Miller M, Bowman E, Mayeda A, Rau NL, Smiley C, Rice JP, Goate A, et al. Initial genomic scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 3, 5, 15, 16, 17, and 22. American Journal of Medical Genetics. 74: 238-46. PMID 9184305 DOI: 10.1002/(Sici)1096-8628(19970531)74:3<238::Aid-Ajmg2>3.0.Co;2-M  1
1997 Nurnberger JI, DePaulo JR, Gershon ES, Reich T, Blehar MC, Edenberg HJ, Foroud T, Miller M, Bowman E, Mayeda A, Rau NL, Smiley C, Conneally PM, McMahon F, Meyers D, ... ... Goate A, et al. Genomic survey of bipolar illness in the NIMH genetics initiative pedigrees: A preliminary report American Journal of Medical Genetics - Neuropsychiatric Genetics. 74: 227-237. PMID 9184304 DOI: 10.1002/(Sici)1096-8628(19970531)74:3<227::Aid-Ajmg1>3.0.Co;2-N  1
1997 Lendon CL, Talbot CJ, Craddock NJ, Han SW, Wragg M, Morris JC, Goate AM. Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population. Neuroscience Letters. 222: 187-90. PMID 9148246 DOI: 10.1016/S0304-3940(97)13381-X  1
1997 Lendon CL, Ashall F, Goate AM. Exploring the etiology of Alzheimer disease using molecular genetics. Jama. 277: 825-31. PMID 9052714 DOI: 10.1001/Jama.1997.03540340059034  1
1997 Lopera F, Ardilla A, Martínez A, Madrigal L, Arango-Viana JC, Lemere CA, Arango-Lasprilla JC, Hincapíe L, Arcos-Burgos M, Ossa JE, Behrens IM, Norton J, Lendon C, Goate AM, Ruiz-Linares A, et al. Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutation. Jama. 277: 793-9. PMID 9052708 DOI: 10.1016/S0002-9394(14)71677-0  1
1997 Lopera̧ F, Martínez A, Madrigal L, Arango-Viana JC, Lemere C, Arango-Lasprilla JC, Hincapié L, Arcos-Burgos M, Ossa JE, Lendon C, Goate A, Ruiz-Linares A, Kosik K. 3-12-16 A large geographical focus of early onset familial Alzheimer's disease in Antioquia, Colombia Journal of the Neurological Sciences. 150. DOI: 10.1016/S0022-510X(97)85613-4  0.64
1997 Han SW, Lendon CL, Goate AM. Genetic association study between a BamHl polymorphism in exon 1 of the protectin gene and dementia of the Alzheimer's type in a Caucasian population Alzheimer's Research. 3: 275-278.  1
1996 Barton AJ, Crook BW, Karran EH, Brown F, Dewar D, Mann DM, Pearson RC, Graham DI, Hardy J, Hutton M, Duff K, Goate AM, Clark RF, Roberts GW. Alteration in brain presenilin 1 mRNA expression in early onset familial Alzheimer's disease. Neurodegeneration : a Journal For Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration. 5: 213-8. PMID 8910899 DOI: 10.1006/Neur.1996.0029  1
1996 Prihar G, Fuldner RA, Perez-Tur J, Lincoln S, Duff K, Crook R, Hardy J, Philips CA, Venter C, Talbot C, Clark RF, Goate A, Li J, Potter H, Karran E, et al. Structure and alternative splicing of the presenilin-2 gene. Neuroreport. 7: 1680-4. PMID 8904781 DOI: 10.1097/00001756-199607080-00031  1
1996 Lemere CA, Lopera F, Kosik KS, Lendon CL, Ossa J, Saido TC, Yamaguchi H, Ruiz A, Martinez A, Madrigal L, Hincapie L, Arango JC, Anthony DC, Koo EH, Goate AM, et al. The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology. Nature Medicine. 2: 1146-50. PMID 8837617 DOI: 10.1038/Nm1096-1146  1
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