Alison M. Goate, PhD - Publications

Affiliations: 
Genetics Washington University, Saint Louis, St. Louis, MO 
Area:
http://www.researchprofiles.collexis.com/jad/expert.asp?u_id=72
Website:
http://dbbs.wustl.edu/rib/goateAli

277 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Hernandez I, Luna G, Rauch JN, Reis SA, Giroux M, Karch CM, Boctor D, Sibih YE, Storm NJ, Diaz A, Kaushik S, Zekanowski C, Kang AA, Hinman CR, Cerovac V, ... ... Goate AM, et al. A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy. Science Translational Medicine. 11. PMID 30918111 DOI: 10.1126/scitranslmed.aat3005  0.8
2019 Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Goate AM, et al. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. 51: 414-430. PMID 30820047 DOI: 10.1038/s41588-019-0358-2  0.68
2019 Preische O, Schultz SA, Apel A, Kuhle J, Kaeser SA, Barro C, Gräber S, Kuder-Buletta E, LaFougere C, Laske C, Vöglein J, Levin J, Masters CL, Martins R, Schofield PR, ... ... Goate AM, et al. Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease. Nature Medicine. PMID 30664784 DOI: 10.1038/s41591-018-0304-3  0.44
2018 McDade E, Wang G, Gordon BA, Hassenstab J, Benzinger TLS, Buckles V, Fagan AM, Holtzman DM, Cairns NJ, Goate AM, Marcus DS, Morris JC, Paumier K, Xiong C, Allegri R, et al. Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease. Neurology. PMID 30217935 DOI: 10.1212/WNL.0000000000006277  0.44
2018 Maxwell TJ, Corcoran C, Del-Aguila JL, Budde JP, Deming Y, Cruchaga C, Goate AM, Kauwe JSK. Genome-wide association study for variants that modulate relationships between cerebrospinal fluid amyloid-beta 42, tau, and p-tau levels. Alzheimer's Research & Therapy. 10: 86. PMID 30153862 DOI: 10.1186/s13195-018-0410-y  0.8
2018 Karch CM, Hernández D, Wang JC, Marsh J, Hewitt AW, Hsu S, Norton J, Levitch D, Donahue T, Sigurdson W, Ghetti B, Farlow M, Chhatwal J, Berman S, Cruchaga C, ... ... Goate AM, et al. Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network. Alzheimer's Research & Therapy. 10: 69. PMID 30045758 DOI: 10.1186/s13195-018-0400-0  0.8
2018 Hsu S, Gordon BA, Hornbeck R, Norton JB, Levitch D, Louden A, Ziegemeier E, Laforce R, Chhatwal J, Day GS, McDade E, Morris JC, Fagan AM, Benzinger TLS, Goate AM, et al. Discovery and validation of autosomal dominant Alzheimer's disease mutations. Alzheimer's Research & Therapy. 10: 67. PMID 30021643 DOI: 10.1186/s13195-018-0392-9  0.8
2018 Deming Y, Dumitrescu L, Barnes LL, Thambisetty M, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Huentelman M, Crane PK, Resnick SM, Keene CD, ... ... Goate AM, et al. Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathologica. PMID 29967939 DOI: 10.1007/s00401-018-1881-4  0.8
2018 Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, ... ... Goate AM, et al. Analysis of shared heritability in common disorders of the brain. Science (New York, N.Y.). 360. PMID 29930110 DOI: 10.1126/science.aap8757  0.6
2018 Fernández MV, Budde J, Del-Aguila JL, Ibañez L, Deming Y, Harari O, Norton J, Morris JC, Goate AM, Cruchaga C. Evaluation of Gene-Based Family-Based Methods to Detect Novel Genes Associated With Familial Late Onset Alzheimer Disease. Frontiers in Neuroscience. 12: 209. PMID 29670507 DOI: 10.3389/fnins.2018.00209  0.8
2018 Sassi C, Nalls MA, Ridge PG, Gibbs JR, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Lord J, Turton J, Bras J, Blumenau S, ... ... Goate AM, et al. Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. Neurobiology of Aging. PMID 29544907 DOI: 10.1016/j.neurobiolaging.2018.01.015  0.8
2018 Ridge PG, Karch CM, Hsu S, Arano I, Teerlink CC, Ebbert MTW, Murcia JDG, Farnham JM, Damato AR, Allen M, Wang X, Harari O, Fernandez VM, Guerreiro R, Bras J, ... ... Goate AM, et al. Correction to: Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome Medicine. 10: 4. PMID 29329552 DOI: 10.1186/s13073-018-0516-7  0.8
2017 Ridge PG, Karch CM, Hsu S, Arano I, Teerlink CC, Ebbert MTW, Gonzalez Murcia JD, Farnham JM, Damato AR, Allen M, Wang X, Harari O, Fernandez VM, Guerreiro R, Bras J, ... ... Goate AM, et al. Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome Medicine. 9: 100. PMID 29183403 DOI: 10.1186/s13073-017-0486-1  0.8
2017 Cruchaga C, Del-Aguila JL, Saef B, Black K, Fernandez MV, Budde J, Ibanez L, Kapoor M, Tosto G, Mayeux RP, Holtzman DM, Fagan AM, Morris JC, Bateman RJ, Goate AM, et al. Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28943286 DOI: 10.1016/j.jalz.2017.08.013  0.8
2017 Tcw J, Wang M, Pimenova AA, Bowles KR, Hartley BJ, Lacin E, Machlovi SI, Abdelaal R, Karch CM, Phatnani H, Slesinger PA, Zhang B, Goate AM, Brennand KJ. An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells. Stem Cell Reports. PMID 28757165 DOI: 10.1016/j.stemcr.2017.06.018  0.8
2017 Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, ... ... Goate AM, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics. PMID 28714976 DOI: 10.1038/ng.3916  0.8
2017 Huang KL, Marcora E, Pimenova AA, Di Narzo AF, Kapoor M, Jin SC, Harari O, Bertelsen S, Fairfax BP, Czajkowski J, Chouraki V, Grenier-Boley B, Bellenguez C, Deming Y, McKenzie A, ... ... Goate AM, et al. A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease. Nature Neuroscience. PMID 28628103 DOI: 10.1038/nn.4587  0.8
2017 Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, ... ... Goate AM, et al. Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. Plos Medicine. 14: e1002258. PMID 28323831 DOI: 10.1371/journal.pmed.1002258  0.8
2017 Deming Y, Li Z, Kapoor M, Harari O, Del-Aguila JL, Black K, Carrell D, Cai Y, Fernandez MV, Budde J, Ma S, Saef B, Howells B, Huang KL, Bertelsen S, ... ... Goate AM, et al. Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers. Acta Neuropathologica. PMID 28247064 DOI: 10.1007/s00401-017-1685-y  0.8
2017 Day GS, Lim TS, Hassenstab J, Goate AM, Grant EA, Roe CM, Cairns NJ, Morris JC. Differentiating cognitive impairment due to corticobasal degeneration and Alzheimer disease. Neurology. PMID 28235814 DOI: 10.1212/WNL.0000000000003770  0.36
2017 Tosto G, Bird TD, Tsuang D, Bennett DA, Boeve BF, Cruchaga C, Faber K, Foroud TM, Farlow M, Goate AM, Bertlesen S, Graff-Radford NR, Medrano M, Lantigua R, Manly J, et al. Polygenic risk scores in familial Alzheimer disease. Neurology. PMID 28213371 DOI: 10.1212/WNL.0000000000003734  0.8
2017 Jun GR, Chung J, Mez J, Barber R, Beecham GW, Bennett DA, Buxbaum JD, Byrd GS, Carrasquillo MM, Crane PK, Cruchaga C, De Jager P, Ertekin-Taner N, Evans D, Fallin MD, ... ... Goate AM, et al. Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28183528 DOI: 10.1016/j.jalz.2016.12.012  0.8
2017 Haddick PC, Larson JL, Rathore N, Bhangale TR, Phung QT, Srinivasan K, Hansen DV, Lill JR, Pericak-Vance MA, Haines J, Farrer LA, Kauwe JS, Schellenberg GD, Cruchaga C, ... Goate AM, et al. A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains. Journal of Alzheimer's Disease : Jad. PMID 28106546 DOI: 10.3233/JAD-160524  0.8
2016 Chapuis J, Flaig A, Grenier-Boley B, Eysert F, Pottiez V, Deloison G, Vandeputte A, Ayral AM, Mendes T, Desai S, Goate AM, Kauwe JS, Leroux F, Herledan A, Demiautte F, et al. Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. Acta Neuropathologica. PMID 27933404 DOI: 10.1007/s00401-016-1652-z  0.8
2016 Monsell SE, Mock C, Fardo DW, Bertelsen S, Cairns NJ, Roe CM, Ellingson SR, Morris JC, Goate AM, Kukull WA. Genetic Comparison of Symptomatic and Asymptomatic Persons With Alzheimer Disease Neuropathology. Alzheimer Disease and Associated Disorders. PMID 27849641 DOI: 10.1097/WAD.0000000000000179  0.44
2016 Deming Y, Black K, Carrell D, Cai Y, Del-Aguila JL, Fernandez MV, Budde J, Ma S, Saef B, Howells B, Bertelsen S, Huang KL, Sutphen CL, Tarawneh R, Fagan AM, ... ... Goate AM, et al. Chitinase-3-like 1 protein (CHI3L1) locus influences cerebrospinal fluid levels of YKL-40. Bmc Neurology. 16: 217. PMID 27832767 DOI: 10.1186/s12883-016-0742-9  0.8
2016 Tosto G, Bird TD, Bennett DA, Boeve BF, Brickman AM, Cruchaga C, Faber K, Foroud TM, Farlow M, Goate AM, Graff-Radford NR, Lantigua R, Manly J, Ottman R, Rosenberg R, et al. The Role of Cardiovascular Risk Factors and Stroke in Familial Alzheimer Disease. Jama Neurology. PMID 27533593 DOI: 10.1001/jamaneurol.2016.2539  0.8
2016 Day GS, Musiek ES, Roe CM, Norton J, Goate AM, Cruchaga C, Cairns NJ, Morris JC. Phenotypic Similarities Between Late-Onset Autosomal Dominant and Sporadic Alzheimer Disease: A Single-Family Case-Control Study. Jama Neurology. PMID 27454811 DOI: 10.1001/jamaneurol.2016.1236  0.8
2016 Ebbert MT, Staley LA, Parker J, Parker S, Bailey M, Ridge PG, Goate AM, Kauwe JS. Variants in CCL16 are associated with blood plasma and cerebrospinal fluid CCL16 protein levels. Bmc Genomics. 17: 437. PMID 27357396 DOI: 10.1186/s12864-016-2788-x  0.44
2016 Staley LA, Ebbert MT, Bunker D, Bailey M, Ridge PG, Goate AM, Kauwe JS. Variants in ACPP are associated with cerebrospinal fluid Prostatic Acid Phosphatase levels. Bmc Genomics. 17: 439. PMID 27357282 DOI: 10.1186/s12864-016-2787-y  0.44
2016 Staley LA, Ebbert MT, Parker S, Bailey M, Ridge PG, Goate AM, Kauwe JS. Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid. Bmc Genomics. 17: 436. PMID 27357110 DOI: 10.1186/s12864-016-2785-0  0.44
2016 Sassi C, Nalls MA, Ridge PG, Gibbs JR, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Clement N, Lord J, Turton J, Bras J, ... ... Goate AM, et al. ABCA7 p.G215S as potential protective factor for Alzheimer's disease. Neurobiology of Aging. PMID 27289440 DOI: 10.1016/j.neurobiolaging.2016.04.004  0.8
2016 Sassi C, Ridge PG, Nalls MA, Gibbs R, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Lord J, Turton J, Morgan K, ... ... Goate AM, et al. Influence of Coding Variability in APP-Aβ Metabolism Genes in Sporadic Alzheimer's Disease. Plos One. 11: e0150079. PMID 27249223 DOI: 10.1371/journal.pone.0150079  0.8
2016 Karch CM, Ezerskiy LA, Bertelsen S, Goate AM. Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci. Plos One. 11: e0148717. PMID 26919393 DOI: 10.1371/journal.pone.0148717  1
2015 Barral S, Cheng R, Reitz C, Vardarajan B, Lee J, Kunkle B, Beecham G, Cantwell LS, Pericak-Vance MA, Farrer LA, Haines JL, Goate AM, Foroud T, Boerwinkle E, Schellenberg GD, et al. Linkage analyses in Caribbean Hispanic families identify novel loci associated with familial late-onset Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26433351 DOI: 10.1016/j.jalz.2015.07.487  0.32
2015 Ghani M, Reitz C, Cheng R, Vardarajan BN, Jun G, Sato C, Naj A, Rajbhandary R, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, ... ... Goate AM, et al. Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals. Jama Neurology. PMID 26366463 DOI: 10.1001/jamaneurol.2015.1700  0.32
2015 Kunkle BW, Jaworski J, Barral S, Vardarajan B, Beecham GW, Martin ER, Cantwell LS, Partch A, Bird TD, Raskind WH, DeStefano AL, Carney RM, Cuccaro M, Vance JM, Farrer LA, ... Goate AM, et al. Genome-wide linkage analyses of non-Hispanic white families identify novel loci for familial late-onset Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26365416 DOI: 10.1016/j.jalz.2015.05.020  0.32
2015 Sadler B, Haller G, Edenberg H, Tischfield J, Brooks A, Kramer J, Schuckit M, Nurnberger J, Goate A. Positive Selection on Loci Associated with Drug and Alcohol Dependence. Plos One. 10: e0134393. PMID 26270548 DOI: 10.1371/journal.pone.0134393  1
2015 Hohman TJ, Cooke-Bailey JN, Reitz C, Jun G, Naj A, Beecham GW, Liu Z, Carney RM, Vance JM, Cuccaro ML, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, ... ... Goate AM, et al. Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26092349 DOI: 10.1016/j.jalz.2015.02.012  1
2015 Mukherjee S, Walter S, Kauwe JS, Saykin AJ, Bennett DA, Larson EB, Crane PK, Glymour MM. Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples: Mendelian randomization analyses. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26079416 DOI: 10.1016/j.jalz.2015.05.015  0.8
2015 Patterson BW, Elbert DL, Mawuenyega KG, Kasten T, Ovod V, Ma S, Xiong C, Chott R, Yarasheski K, Sigurdson W, Zhang L, Goate A, Benzinger T, Morris JC, Holtzman D, et al. Age and amyloid effects on human CNS amyloid-beta kinetics. Annals of Neurology. PMID 26040676 DOI: 10.1002/ana.24454  1
2015 Kotyuk E, Duchek J, Head D, Szekely A, Goate AM, Balota DA. A Genetic Variant (COMT) Coding Dopaminergic Activity Predicts Personality Traits in Healthy Elderly. Personality and Individual Differences. 82: 61-66. PMID 25960587 DOI: 10.1016/j.paid.2015.03.012  1
2015 Jin SC, Carrasquillo MM, Benitez BA, Skorupa T, Carrell D, Patel D, Lincoln S, Krishnan S, Kachadoorian M, Reitz C, Mayeux R, Wingo TS, Lah JJ, Levey AI, Murrell J, ... ... Goate AM, et al. TREM2 is associated with increased risk for Alzheimer's disease in African Americans. Molecular Neurodegeneration. 10: 19. PMID 25886450 DOI: 10.1186/s13024-015-0016-9  1
2015 Cruchaga C, Goate AM. Cruchaga & Goate reply. Nature. 520: E5-6. PMID 25832412 DOI: 10.1038/nature14037  1
2015 Cruchaga C, Goate AM. Cruchaga & Goate reply. Nature. 520: E10. PMID 25832409 DOI: 10.1038/nature14041  1
2015 Kim A, Fagan AM, Goate AM, Benzinger TL, Morris JC, Head D. Lack of an association of BDNF Val66Met polymorphism and plasma BDNF with hippocampal volume and memory. Cognitive, Affective & Behavioral Neuroscience. PMID 25784293 DOI: 10.3758/s13415-015-0343-x  1
2015 Jun G, Ibrahim-Verbaas CA, Vronskaya M, Lambert JC, Chung J, Naj AC, Kunkle BW, Wang LS, Bis JC, Bellenguez C, Harold D, Lunetta KL, Destefano AL, Grenier-Boley B, Sims R, ... ... Goate AM, et al. A novel Alzheimer disease locus located near the gene encoding tau protein. Molecular Psychiatry. PMID 25778476 DOI: 10.1038/mp.2015.23  0.8
2015 Bailey HR, Sargent JQ, Flores S, Nowotny P, Goate A, Zacks JM. APOE ε4 genotype predicts memory for everyday activities. Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition. 1-28. PMID 25754878 DOI: 10.1080/13825585.2015.1020916  1
2015 Ringman JM, Liang LJ, Zhou Y, Vangala S, Teng E, Kremen S, Wharton D, Goate A, Marcus DS, Farlow M, Ghetti B, McDade E, Masters CL, Mayeux RP, Rossor M, et al. Early behavioural changes in familial Alzheimer's disease in the Dominantly Inherited Alzheimer Network. Brain : a Journal of Neurology. 138: 1036-45. PMID 25688083 DOI: 10.1093/brain/awv004  1
2015 . Convergent genetic and expression data implicate immunity in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 658-71. PMID 25533204 DOI: 10.1016/j.jalz.2014.05.1757  1
2015 Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, ... ... Goate AM, et al. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. Jama Neurology. 72: 209-16. PMID 25531812 DOI: 10.1001/jamaneurol.2014.2157  0.8
2015 Blednov YA, Benavidez JM, Black M, Ferguson LB, Schoenhard GL, Goate AM, Edenberg HJ, Wetherill L, Hesselbrock V, Foroud T, Harris RA. Peroxisome proliferator-activated receptors α and γ are linked with alcohol consumption in mice and withdrawal and dependence in humans. Alcoholism, Clinical and Experimental Research. 39: 136-45. PMID 25516156 DOI: 10.1111/acer.12610  1
2015 Cady J, Allred P, Bali T, Pestronk A, Goate A, Miller TM, Mitra RD, Ravits J, Harms MB, Baloh RH. Amyotrophic lateral sclerosis onset is influenced by the burden of rare variants in known amyotrophic lateral sclerosis genes. Annals of Neurology. 77: 100-13. PMID 25382069 DOI: 10.1002/ana.24306  1
2015 Karch CM, Goate AM. Alzheimer's disease risk genes and mechanisms of disease pathogenesis. Biological Psychiatry. 77: 43-51. PMID 24951455 DOI: 10.1016/j.biopsych.2014.05.006  1
2015 Wetherill L, Agrawal A, Kapoor M, Bertelsen S, Bierut LJ, Brooks A, Dick D, Hesselbrock M, Hesselbrock V, Koller DL, Le N, Nurnberger JI, Salvatore JE, Schuckit M, Tischfield JA, ... ... Goate AM, et al. Association of substance dependence phenotypes in the COGA sample. Addiction Biology. 20: 617-27. PMID 24832863 DOI: 10.1111/adb.12153  1
2015 Ghani M, Reitz C, Cheng R, Vardarajan BN, Jun G, Sato C, Naj A, Rajbhandary R, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, ... ... Goate AM, et al. Association of long runs of homozygosity with Alzheimer disease among African American individuals Jama Neurology. 72: 1313-1323. DOI: 10.1001/jamaneurol.2015.1700z  0.32
2014 Izzo NJ, Xu J, Zeng C, Kirk MJ, Mozzoni K, Silky C, Rehak C, Yurko R, Look G, Rishton G, Safferstein H, Cruchaga C, Goate A, Cahill MA, Arancio O, et al. Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity. Plos One. 9: e111899. PMID 25390692 DOI: 10.1371/journal.pone.0111899  1
2014 Kauwe JS, Bailey MH, Ridge PG, Perry R, Wadsworth ME, Hoyt KL, Staley LA, Karch CM, Harari O, Cruchaga C, Ainscough BJ, Bales K, Pickering EH, Bertelsen S, ... ... Goate AM, et al. Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation. Plos Genetics. 10: e1004758. PMID 25340798 DOI: 10.1371/journal.pgen.1004758  1
2014 Olfson E, Edenberg HJ, Nurnberger J, Agrawal A, Bucholz KK, Almasy LA, Chorlian D, Dick DM, Hesselbrock VM, Kramer JR, Kuperman S, Porjesz B, Schuckit MA, Tischfield JA, Wang JC, ... ... Goate A, et al. An ADH1B variant and peer drinking in progression to adolescent drinking milestones: evidence of a gene-by-environment interaction. Alcoholism, Clinical and Experimental Research. 38: 2541-9. PMID 25257461 DOI: 10.1111/acer.12524  1
2014 Proitsi P, Lupton MK, Velayudhan L, Newhouse S, Fogh I, Tsolaki M, Daniilidou M, Pritchard M, Kloszewska I, Soininen H, Mecocci P, Vellas B, Williams J, et al. Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease: a mendelian randomization analysis. Plos Medicine. 11: e1001713. PMID 25226301 DOI: 10.1371/journal.pmed.1001713  1
2014 Ringman JM, Goate A, Masters CL, Cairns NJ, Danek A, Graff-Radford N, Ghetti B, Morris JC. Genetic heterogeneity in Alzheimer disease and implications for treatment strategies. Current Neurology and Neuroscience Reports. 14: 499. PMID 25217249 DOI: 10.1007/s11910-014-0499-8  1
2014 Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, ... ... Goate AM, et al. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. Jama Neurology. 71: 1394-404. PMID 25199842 DOI: 10.1001/jamaneurol.2014.1491  1
2014 Logue MW, Schu M, Vardarajan BN, Farrell J, Bennett DA, Buxbaum JD, Byrd GS, Ertekin-Taner N, Evans D, Foroud T, Goate A, Graff-Radford NR, Kamboh MI, Kukull WA, Manly JJ, et al. Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: 609-618.e11. PMID 25172201 DOI: 10.1016/j.jalz.2014.06.010  1
2014 Bloom AJ, Hartz SM, Baker TB, Chen LS, Piper ME, Fox L, Martinez M, Hatsukami D, Johnson EO, Laurie CC, Saccone NL, Goate A, Bierut LJ. Beyond cigarettes per day. A genome-wide association study of the biomarker carbon monoxide. Annals of the American Thoracic Society. 11: 1003-10. PMID 25072098 DOI: 10.1513/AnnalsATS.201401-010OC  1
2014 Thomas JB, Brier MR, Bateman RJ, Snyder AZ, Benzinger TL, Xiong C, Raichle M, Holtzman DM, Sperling RA, Mayeux R, Ghetti B, Ringman JM, Salloway S, McDade E, Rossor MN, ... ... Goate AM, et al. Functional connectivity in autosomal dominant and late-onset Alzheimer disease. Jama Neurology. 71: 1111-22. PMID 25069482 DOI: 10.1001/jamaneurol.2014.1654  1
2014 Karch CM, Cruchaga C, Goate AM. Alzheimer's disease genetics: from the bench to the clinic. Neuron. 83: 11-26. PMID 24991952 DOI: 10.1016/j.neuron.2014.05.041  1
2014 Kapoor M, Wang JC, Wetherill L, Le N, Bertelsen S, Hinrichs AL, Budde J, Agrawal A, Almasy L, Bucholz K, Dick DM, Harari O, Xiaoling X, Hesselbrock V, Kramer J, ... ... Goate A, et al. Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families. Drug and Alcohol Dependence. 142: 56-62. PMID 24962325 DOI: 10.1016/j.drugalcdep.2014.05.023  1
2014 Ryman DC, Acosta-Baena N, Aisen PS, Bird T, Danek A, Fox NC, Goate A, Frommelt P, Ghetti B, Langbaum JB, Lopera F, Martins R, Masters CL, Mayeux RP, McDade E, et al. Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis. Neurology. 83: 253-60. PMID 24928124 DOI: 10.1212/WNL.0000000000000596  1
2014 Wang JC, Kapoor M, Goate AM. Association of genes involved in calcium and potassium pathways with opioid dependence. Biological Psychiatry. 76: 6-7. PMID 24925890 DOI: 10.1016/j.biopsych.2014.04.012  1
2014 Escott-Price V, Bellenguez C, Wang LS, Choi SH, Harold D, Jones L, Holmans P, Gerrish A, Vedernikov A, Richards A, DeStefano AL, Lambert JC, Ibrahim-Verbaas CA, Naj AC, Sims R, ... ... Goate AM, et al. Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease. Plos One. 9: e94661. PMID 24922517 DOI: 10.1371/journal.pone.0094661  1
2014 Jin SC, Benitez BA, Karch CM, Cooper B, Skorupa T, Carrell D, Norton JB, Hsu S, Harari O, Cai Y, Bertelsen S, Goate AM, Cruchaga C. Coding variants in TREM2 increase risk for Alzheimer's disease. Human Molecular Genetics. 23: 5838-46. PMID 24899047 DOI: 10.1093/hmg/ddu277  1
2014 Haller G, Li P, Esch C, Hsu S, Goate AM, Steinbach JH. Functional characterization improves associations between rare non-synonymous variants in CHRNB4 and smoking behavior. Plos One. 9: e96753. PMID 24804708 DOI: 10.1371/journal.pone.0096753  1
2014 Sadler B, Haller G, Agrawal A, Culverhouse R, Bucholz K, Brooks A, Tischfield J, Johnson EO, Edenberg H, Schuckit M, Saccone N, Bierut L, Goate A. Variants near CHRNB3-CHRNA6 are associated with DSM-5 cocaine use disorder: evidence for pleiotropy. Scientific Reports. 4: 4497. PMID 24675634 DOI: 10.1038/srep04497  1
2014 Fagan AM, Xiong C, Jasielec MS, Bateman RJ, Goate AM, Benzinger TL, Ghetti B, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Salloway S, Schofield PR, Sperling RA, et al. Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease. Science Translational Medicine. 6: 226ra30. PMID 24598588 DOI: 10.1126/scitranslmed.3007901  1
2014 Harari O, Cruchaga C, Kauwe JS, Ainscough BJ, Bales K, Pickering EH, Bertelsen S, Fagan AM, Holtzman DM, Morris JC, Goate AM. Phosphorylated tau-Aβ42 ratio as a continuous trait for biomarker discovery for early-stage Alzheimer's disease in multiplex immunoassay panels of cerebrospinal fluid. Biological Psychiatry. 75: 723-31. PMID 24548642 DOI: 10.1016/j.biopsych.2013.11.032  1
2014 Cady J, Koval ED, Benitez BA, Zaidman C, Jockel-Balsarotti J, Allred P, Baloh RH, Ravits J, Simpson E, Appel SH, Pestronk A, Goate AM, Miller TM, Cruchaga C, Harms MB. TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis. Jama Neurology. 71: 449-53. PMID 24535663 DOI: 10.1001/jamaneurol.2013.6237  1
2014 Benitez BA, Jin SC, Guerreiro R, Graham R, Lord J, Harold D, Sims R, Lambert JC, Gibbs JR, Bras J, Sassi C, Harari O, Bertelsen S, Lupton MK, Powell J, ... ... Goate AM, et al. Missense variant in TREML2 protects against Alzheimer's disease. Neurobiology of Aging. 35: 1510.e19-26. PMID 24439484 DOI: 10.1016/j.neurobiolaging.2013.12.010  1
2014 Vardarajan BN, Faber KM, Bird TD, Bennett DA, Rosenberg R, Boeve BF, Graff-Radford NR, Goate AM, Farlow M, Sweet RA, Lantigua R, Medrano MZ, Ottman R, Schaid DJ, Foroud TM, et al. Age-specific incidence rates for dementia and Alzheimer disease in NIA-LOAD/NCRAD and EFIGA families: National Institute on Aging Genetics Initiative for Late-Onset Alzheimer Disease/National Cell Repository for Alzheimer Disease (NIA-LOAD/NCRAD) and Estudio Familiar de Influencia Genetica en Alzheimer (EFIGA). Jama Neurology. 71: 315-23. PMID 24425039 DOI: 10.1001/jamaneurol.2013.5570  1
2014 Ting SK, Benzinger T, Kepe V, Fagan A, Coppola G, Porter V, Hecimovic S, Chakraverty S, Alvarez-Retuerto AI, Goate A, Ringman JM. A novel PSEN1 mutation (I238M) associated with early-onset Alzheimer's disease in an African-American woman. Journal of Alzheimer's Disease : Jad. 40: 271-5. PMID 24413619 DOI: 10.3233/JAD-131844  1
2014 Culverhouse RC, Johnson EO, Breslau N, Hatsukami DK, Sadler B, Brooks AI, Hesselbrock VM, Schuckit MA, Tischfield JA, Goate AM, Saccone NL, Bierut LJ. Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans. Addiction (Abingdon, England). 109: 814-22. PMID 24401102 DOI: 10.1111/add.12478  1
2014 Cruchaga C, Karch CM, Jin SC, Benitez BA, Cai Y, Guerreiro R, Harari O, Norton J, Budde J, Bertelsen S, Jeng AT, Cooper B, Skorupa T, Carrell D, Levitch D, ... ... Goate AM, et al. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease. Nature. 505: 550-4. PMID 24336208 DOI: 10.1038/nature12825  1
2014 Agrawal A, Lynskey MT, Bucholz KK, Kapoor M, Almasy L, Dick DM, Edenberg HJ, Foroud T, Goate A, Hancock DB, Hartz S, Johnson EO, Hesselbrock V, Kramer JR, Kuperman S, et al. DSM-5 cannabis use disorder: a phenotypic and genomic perspective. Drug and Alcohol Dependence. 134: 362-9. PMID 24315570 DOI: 10.1016/j.drugalcdep.2013.11.008  1
2014 Haller G, Kapoor M, Budde J, Xuei X, Edenberg H, Nurnberger J, Kramer J, Brooks A, Tischfield J, Almasy L, Agrawal A, Bucholz K, Rice J, Saccone N, Bierut L, ... Goate A, et al. Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence. Human Molecular Genetics. 23: 810-9. PMID 24057674 DOI: 10.1093/hmg/ddt463  1
2014 Bloom AJ, Baker TB, Chen LS, Breslau N, Hatsukami D, Bierut LJ, Goate A. Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms. Human Molecular Genetics. 23: 555-61. PMID 24045616 DOI: 10.1093/hmg/ddt432  1
2014 Chen LS, Bloom AJ, Baker TB, Smith SS, Piper ME, Martinez M, Saccone N, Hatsukami D, Goate A, Bierut L. Pharmacotherapy effects on smoking cessation vary with nicotine metabolism gene (CYP2A6). Addiction (Abingdon, England). 109: 128-37. PMID 24033696 DOI: 10.1111/add.12353  1
2014 Wetherill L, Kapoor M, Agrawal A, Bucholz K, Koller D, Bertelsen SE, Le N, Wang JC, Almasy L, Hesselbrock V, Kramer J, Nurnberger JI, Schuckit M, Tischfield JA, Xuei X, ... ... Goate AM, et al. Family-based association analysis of alcohol dependence criteria and severity. Alcoholism, Clinical and Experimental Research. 38: 354-66. PMID 24015780 DOI: 10.1111/acer.12251  1
2014 Peterson D, Munger C, Crowley J, Corcoran C, Cruchaga C, Goate AM, Norton MC, Green RC, Munger RG, Breitner JC, Welsh-Bohmer KA, Lyketsos C, Tschanz J, Kauwe JS. Variants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer's disease: the Cache County Dementia Progression Study. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: 366-71. PMID 23727081 DOI: 10.1016/j.jalz.2013.02.010  1
2014 Dick DM, Cho SB, Latendresse SJ, Aliev F, Nurnberger JI, Edenberg HJ, Schuckit M, Hesselbrock VM, Porjesz B, Bucholz K, Wang JC, Goate A, Kramer JR, Kuperman S. Genetic influences on alcohol use across stages of development: GABRA2 and longitudinal trajectories of drunkenness from adolescence to young adulthood. Addiction Biology. 19: 1055-64. PMID 23692184 DOI: 10.1111/adb.12066  1
2014 Yan J, Aliev F, Webb BT, Kendler KS, Williamson VS, Edenberg HJ, Agrawal A, Kos MZ, Almasy L, Nurnberger JI, Schuckit MA, Kramer JR, Rice JP, Kuperman S, Goate AM, et al. Using genetic information from candidate gene and genome-wide association studies in risk prediction for alcohol dependence. Addiction Biology. 19: 708-21. PMID 23362995 DOI: 10.1111/adb.12035  1
2013 Wang JC, Spiegel N, Bertelsen S, Le N, McKenna N, Budde JP, Harari O, Kapoor M, Brooks A, Hancock D, Tischfield J, Foroud T, Bierut LJ, Steinbach JH, Edenberg HJ, ... ... Goate AM, et al. Cis-regulatory variants affect CHRNA5 mRNA expression in populations of African and European ancestry. Plos One. 8: e80204. PMID 24303001 DOI: 10.1371/journal.pone.0080204  1
2013 Bloom AJ, Martinez M, Chen LS, Bierut LJ, Murphy SE, Goate A. CYP2B6 non-coding variation associated with smoking cessation is also associated with differences in allelic expression, splicing, and nicotine metabolism independent of common amino-acid changes. Plos One. 8: e79700. PMID 24260284 DOI: 10.1371/journal.pone.0079700  1
2013 Benzinger TL, Blazey T, Jack CR, Koeppe RA, Su Y, Xiong C, Raichle ME, Snyder AZ, Ances BM, Bateman RJ, Cairns NJ, Fagan AM, Goate A, Marcus DS, Aisen PS, et al. Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 110: E4502-9. PMID 24194552 DOI: 10.1073/pnas.1317918110  1
2013 Bloom AJ, von Weymarn LB, Martinez M, Bierut LJ, Goate A, Murphy SE. The contribution of common UGT2B10 and CYP2A6 alleles to variation in nicotine glucuronidation among European Americans. Pharmacogenetics and Genomics. 23: 706-16. PMID 24192532 DOI: 10.1097/FPC.0000000000000011  1
2013 Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, DeStafano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thorton-Wells TA, Jones N, Smith AV, Chouraki V, ... ... Goate AM, et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nature Genetics. 45: 1452-8. PMID 24162737 DOI: 10.1038/ng.2802  0.8
2013 Honea RA, Cruchaga C, Perea RD, Saykin AJ, Burns JM, Weinberger DR, Goate AM. Characterizing the role of brain derived neurotrophic factor genetic variation in Alzheimer's disease neurodegeneration. Plos One. 8: e76001. PMID 24086677 DOI: 10.1371/journal.pone.0076001  1
2013 Mills SM, Mallmann J, Santacruz AM, Fuqua A, Carril M, Aisen PS, Althage MC, Belyew S, Benzinger TL, Brooks WS, Buckles VD, Cairns NJ, Clifford D, Danek A, Fagan AM, ... ... Goate AM, et al. Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial. Revue Neurologique. 169: 737-43. PMID 24016464 DOI: 10.1016/j.neurol.2013.07.017  1
2013 Benitez BA, Karch CM, Cai Y, Jin SC, Cooper B, Carrell D, Bertelsen S, Chibnik L, Schneider JA, Bennett DA, Fagan AM, Holtzman D, Morris JC, ... Goate AM, et al. The PSEN1, p.E318G variant increases the risk of Alzheimer's disease in APOE-ε4 carriers. Plos Genetics. 9: e1003685. PMID 23990795 DOI: 10.1371/journal.pgen.1003685  1
2013 McClintick JN, Xuei X, Tischfield JA, Goate A, Foroud T, Wetherill L, Ehringer MA, Edenberg HJ. Stress-response pathways are altered in the hippocampus of chronic alcoholics. Alcohol (Fayetteville, N.Y.). 47: 505-15. PMID 23981442 DOI: 10.1016/j.alcohol.2013.07.002  1
2013 Chorlian DB, Rangaswamy M, Manz N, Wang JC, Dick D, Almasy L, Bauer L, Bucholz K, Foroud T, Hesselbrock V, Kang SJ, Kramer J, Kuperman S, Nurnberger J, Rice J, ... ... Goate A, et al. Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults. Behavior Genetics. 43: 386-401. PMID 23963516 DOI: 10.1007/s10519-013-9604-z  1
2013 Frost SM, Kanagasingam Y, Sohrabi HR, Taddei K, Bateman R, Morris J, Benzinger T, Goate A, Masters CL, Martins RN. Pupil response biomarkers distinguish amyloid precursor protein mutation carriers from non-carriers. Current Alzheimer Research. 10: 790-6. PMID 23919771 DOI: 10.2174/15672050113109990154  1
2013 Chhatwal JP, Schultz AP, Johnson K, Benzinger TL, Jack C, Ances BM, Sullivan CA, Salloway SP, Ringman JM, Koeppe RA, Marcus DS, Thompson P, Saykin AJ, Correia S, Schofield PR, ... ... Goate AM, et al. Impaired default network functional connectivity in autosomal dominant Alzheimer disease. Neurology. 81: 736-44. PMID 23884042 DOI: 10.1212/WNL.0b013e3182a1aafe  1
2013 Campbell MC, Markham J, Flores H, Hartlein JM, Goate AM, Cairns NJ, Videen TO, Perlmutter JS. Principal component analysis of PiB distribution in Parkinson and Alzheimer diseases. Neurology. 81: 520-7. PMID 23825179 DOI: 10.1212/WNL.0b013e31829e6f94  1
2013 Potter R, Patterson BW, Elbert DL, Ovod V, Kasten T, Sigurdson W, Mawuenyega K, Blazey T, Goate A, Chott R, Yarasheski KE, Holtzman DM, Morris JC, Benzinger TL, Bateman RJ. Increased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriers. Science Translational Medicine. 5: 189ra77. PMID 23761040 DOI: 10.1126/scitranslmed.3005615  1
2013 Karch CM, Jeng AT, Skorupa T, Cruchaga C, Goate AM. Novel progranulin variants do not disrupt progranulin secretion and cleavage. Neurobiology of Aging. 34: 2538-40. PMID 23759146 DOI: 10.1016/j.neurobiolaging.2013.05.004  1
2013 Kapoor M, Wang JC, Wetherill L, Le N, Bertelsen S, Hinrichs AL, Budde J, Agrawal A, Bucholz K, Dick D, Harari O, Hesselbrock V, Kramer J, Nurnberger JI, Rice J, ... ... Goate A, et al. A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks. Human Genetics. 132: 1141-51. PMID 23743675 DOI: 10.1007/s00439-013-1318-z  1
2013 Zhang Z, Wang JC, Howells W, Lin P, Agrawal A, Edenberg HJ, Tischfield JA, Schuckit MA, Bierut LJ, Goate A, Rice JP. Dosage transmission disequilibrium test (dTDT) for linkage and association detection. Plos One. 8: e63526. PMID 23691058 DOI: 10.1371/journal.pone.0063526  1
2013 Kos MZ, Yan J, Dick DM, Agrawal A, Bucholz KK, Rice JP, Johnson EO, Schuckit M, Kuperman S, Kramer J, Goate AM, Tischfield JA, Foroud T, Nurnberger J, Hesselbrock V, et al. Common biological networks underlie genetic risk for alcoholism in African- and European-American populations. Genes, Brain, and Behavior. 12: 532-42. PMID 23607416 DOI: 10.1111/gbb.12043  1
2013 Harms MB, Cady J, Zaidman C, Cooper P, Bali T, Allred P, Cruchaga C, Baughn M, Libby RT, Pestronk A, Goate A, Ravits J, Baloh RH. Lack of C9ORF72 coding mutations supports a gain of function for repeat expansions in amyotrophic lateral sclerosis. Neurobiology of Aging. 34: 2234.e13-9. PMID 23597494 DOI: 10.1016/j.neurobiolaging.2013.03.006  1
2013 Harms M, Benitez BA, Cairns N, Cooper B, Cooper P, Mayo K, Carrell D, Faber K, Williamson J, Bird T, Diaz-Arrastia R, Foroud TM, Boeve BF, Graff-Radford NR, Mayeux R, ... ... Goate AM, et al. C9orf72 hexanucleotide repeat expansions in clinical Alzheimer disease. Jama Neurology. 70: 736-41. PMID 23588422 DOI: 10.1001/2013.jamaneurol.537  1
2013 Reitz C, Jun G, Naj A, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, ... ... Goate AM, et al. Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans. Jama. 309: 1483-92. PMID 23571587 DOI: 10.1001/jama.2013.2973  1
2013 Cruchaga C, Kauwe JS, Harari O, Jin SC, Cai Y, Karch CM, Benitez BA, Jeng AT, Skorupa T, Carrell D, Bertelsen S, Bailey M, McKean D, Shulman JM, De Jager PL, ... ... Goate AM, et al. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. Neuron. 78: 256-68. PMID 23562540 DOI: 10.1016/j.neuron.2013.02.026  1
2013 Morgan EE, Woods SP, Letendre SL, Franklin DR, Bloss C, Goate A, Heaton RK, Collier AC, Marra CM, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Ellis RJ, et al. Apolipoprotein E4 genotype does not increase risk of HIV-associated neurocognitive disorders. Journal of Neurovirology. 19: 150-6. PMID 23408335 DOI: 10.1007/s13365-013-0152-3  1
2013 Bloom AJ, Harari O, Martinez M, Zhang X, McDonald SA, Murphy SE, Goate A. A compensatory effect upon splicing results in normal function of the CYP2A6*14 allele. Pharmacogenetics and Genomics. 23: 107-16. PMID 23292114 DOI: 10.1097/FPC.0b013e32835caf7d  1
2013 Bloom AJ, Murphy SE, Martinez M, von Weymarn LB, Bierut LJ, Goate A. Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption. Pharmacogenetics and Genomics. 23: 62-8. PMID 23211429 DOI: 10.1097/FPC.0b013e32835c3b48  1
2013 Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, ... ... Goate A, et al. TREM2 variants in Alzheimer's disease. The New England Journal of Medicine. 368: 117-27. PMID 23150934 DOI: 10.1056/NEJMoa1211851  1
2013 Harms MB, Neumann D, Benitez BA, Cooper B, Carrell D, Racette BA, Perlmutter JS, Goate A, Cruchaga C. Parkinson disease is not associated with C9ORF72 repeat expansions. Neurobiology of Aging. 34: 1519.e1-2. PMID 23116878 DOI: 10.1016/j.neurobiolaging.2012.10.001  1
2013 Wang JC, Foroud T, Hinrichs AL, Le NX, Bertelsen S, Budde JP, Harari O, Koller DL, Wetherill L, Agrawal A, Almasy L, Brooks AI, Bucholz K, Dick D, Hesselbrock V, ... ... Goate AM, et al. A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53. Molecular Psychiatry. 18: 1218-24. PMID 23089632 DOI: 10.1038/mp.2012.143  1
2013 Karch CM, Jeng AT, Goate AM. Calcium phosphatase calcineurin influences tau metabolism. Neurobiology of Aging. 34: 374-86. PMID 22676853 DOI: 10.1016/j.neurobiolaging.2012.05.003  1
2012 Harari O, Wang JC, Bucholz K, Edenberg HJ, Heath A, Martin NG, Pergadia ML, Montgomery G, Schrage A, Bierut LJ, Madden PF, Goate AM. Pathway analysis of smoking quantity in multiple GWAS identifies cholinergic and sensory pathways. Plos One. 7: e50913. PMID 23227220 DOI: 10.1371/journal.pone.0050913  1
2012 Karch CM, Jeng AT, Nowotny P, Cady J, Cruchaga C, Goate AM. Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains. Plos One. 7: e50976. PMID 23226438 DOI: 10.1371/journal.pone.0050976  1
2012 Morris JC, Aisen PS, Bateman RJ, Benzinger TL, Cairns NJ, Fagan AM, Ghetti B, Goate AM, Holtzman DM, Klunk WE, McDade E, Marcus DS, Martins RN, Masters CL, Mayeux R, et al. Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network. Clinical Investigation. 2: 975-984. PMID 23139856 DOI: 10.4155/cli.12.93  0.44
2012 Karch CM, Jeng AT, Goate AM. Extracellular Tau levels are influenced by variability in Tau that is associated with tauopathies. The Journal of Biological Chemistry. 287: 42751-62. PMID 23105105 DOI: 10.1074/jbc.M112.380642  1
2012 Jin SC, Pastor P, Cooper B, Cervantes S, Benitez BA, Razquin C, Goate A, Cruchaga C. Pooled-DNA sequencing identifies novel causative variants in PSEN1, GRN and MAPT in a clinical early-onset and familial Alzheimer's disease Ibero-American cohort. Alzheimer's Research & Therapy. 4: 34. PMID 22906081 DOI: 10.1186/alzrt137  1
2012 Cruchaga C, Kauwe JS, Nowotny P, Bales K, Pickering EH, Mayo K, Bertelsen S, Hinrichs A, Fagan AM, Holtzman DM, Morris JC, Goate AM. Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease. Human Molecular Genetics. 21: 4558-71. PMID 22821396 DOI: 10.1093/hmg/dds296  1
2012 Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, Marcus DS, Cairns NJ, Xie X, Blazey TM, Holtzman DM, Santacruz A, Buckles V, Oliver A, Moulder K, et al. Clinical and biomarker changes in dominantly inherited Alzheimer's disease. The New England Journal of Medicine. 367: 795-804. PMID 22784036 DOI: 10.1056/NEJMoa1202753  1
2012 Wang JC, Kapoor M, Goate AM. The genetics of substance dependence. Annual Review of Genomics and Human Genetics. 13: 241-61. PMID 22703173 DOI: 10.1146/annurev-genom-090711-163844  1
2012 Lin P, Hartz SM, Wang JC, Agrawal A, Zhang TX, McKenna N, Bucholz K, Brooks AI, Tischfield JA, Edenberg HJ, Hesselbrock VM, Kramer JR, Kuperman S, Schuckit MA, Goate AM, et al. Copy number variations in 6q14.1 and 5q13.2 are associated with alcohol dependence. Alcoholism, Clinical and Experimental Research. 36: 1512-8. PMID 22702843 DOI: 10.1111/j.1530-0277.2012.01758.x  1
2012 Wildsmith KR, Basak JM, Patterson BW, Pyatkivskyy Y, Kim J, Yarasheski KE, Wang JX, Mawuenyega KG, Jiang H, Parsadanian M, Yoon H, Kasten T, Sigurdson WC, Xiong C, Goate A, et al. In vivo human apolipoprotein E isoform fractional turnover rates in the CNS. Plos One. 7: e38013. PMID 22675504 DOI: 10.1371/journal.pone.0038013  1
2012 Chen LS, Baker TB, Piper ME, Breslau N, Cannon DS, Doheny KF, Gogarten SM, Johnson EO, Saccone NL, Wang JC, Weiss RB, Goate AM, Bierut LJ. Interplay of genetic risk factors (CHRNA5-CHRNA3-CHRNB4) and cessation treatments in smoking cessation success. The American Journal of Psychiatry. 169: 735-42. PMID 22648373 DOI: 10.1176/appi.ajp.2012.11101545  1
2012 Kang SJ, Rangaswamy M, Manz N, Wang JC, Wetherill L, Hinrichs T, Almasy L, Brooks A, Chorlian DB, Dick D, Hesselbrock V, Kramer J, Kuperman S, Nurnberger J, Rice J, ... ... Goate A, et al. Family-based genome-wide association study of frontal θ oscillations identifies potassium channel gene KCNJ6. Genes, Brain, and Behavior. 11: 712-9. PMID 22554406 DOI: 10.1111/j.1601-183X.2012.00803.x  1
2012 Chen LS, Saccone NL, Culverhouse RC, Bracci PM, Chen CH, Dueker N, Han Y, Huang H, Jin G, Kohno T, Ma JZ, Przybeck TR, Sanders AR, Smith JA, Sung YJ, ... ... Goate AM, et al. Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25. Genetic Epidemiology. 36: 340-51. PMID 22539395 DOI: 10.1002/gepi.21627  1
2012 Rice JP, Hartz SM, Agrawal A, Almasy L, Bennett S, Breslau N, Bucholz KK, Doheny KF, Edenberg HJ, Goate AM, Hesselbrock V, Howells WB, Johnson EO, Kramer J, Krueger RF, et al. CHRNB3 is more strongly associated with Fagerström test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results. Addiction (Abingdon, England). 107: 2019-28. PMID 22524403 DOI: 10.1111/j.1360-0443.2012.03922.x  1
2012 Bloom AJ, Harari O, Martinez M, Madden PA, Martin NG, Montgomery GW, Rice JP, Murphy SE, Bierut LJ, Goate A. Use of a predictive model derived from in vivo endophenotype measurements to demonstrate associations with a complex locus, CYP2A6. Human Molecular Genetics. 21: 3050-62. PMID 22451501 DOI: 10.1093/hmg/dds114  1
2012 Shi H, Belbin O, Medway C, Brown K, Kalsheker N, Carrasquillo M, Proitsi P, Powell J, Lovestone S, Goate A, Younkin S, Passmore P, Morgan K. Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS). Neurobiology of Aging. 33: 1849.e5-18. PMID 22445811 DOI: 10.1016/j.neurobiolaging.2012.02.014  1
2012 Kapoor M, Wang JC, Bertelsen S, Bucholz K, Budde JP, Hinrichs A, Agrawal A, Brooks A, Chorlian D, Dick D, Hesselbrock V, Foroud T, Kramer J, Kuperman S, Manz N, ... ... Goate AM, et al. Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking. Plos One. 7: e33513. PMID 22438940 DOI: 10.1371/journal.pone.0033513  1
2012 Derringer J, Krueger RF, Dick DM, Aliev F, Grucza RA, Saccone S, Agrawal A, Edenberg HJ, Goate AM, Hesselbrock VM, Kramer JR, Lin P, Neuman RJ, Nurnberger JI, Rice JP, et al. The aggregate effect of dopamine genes on dependence symptoms among cocaine users: cross-validation of a candidate system scoring approach. Behavior Genetics. 42: 626-35. PMID 22358648 DOI: 10.1007/s10519-012-9531-4  1
2012 Cruchaga C, Haller G, Chakraverty S, Mayo K, Vallania FL, Mitra RD, Faber K, Williamson J, Bird T, Diaz-Arrastia R, Foroud TM, Boeve BF, Graff-Radford NR, St Jean P, Lawson M, ... ... Goate AM, et al. Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families. Plos One. 7: e31039. PMID 22312439 DOI: 10.1371/journal.pone.0031039  1
2012 Head D, Bugg JM, Goate AM, Fagan AM, Mintun MA, Benzinger T, Holtzman DM, Morris JC. Exercise Engagement as a Moderator of the Effects of APOE Genotype on Amyloid Deposition. Archives of Neurology. 69: 636-43. PMID 22232206 DOI: 10.1001/archneurol.2011.845  1
2012 Chen LS, Baker TB, Grucza R, Wang JC, Johnson EO, Breslau N, Hatsukami D, Smith SS, Saccone N, Saccone S, Rice JP, Goate AM, Bierut LJ. Dissection of the phenotypic and genotypic associations with nicotinic dependence. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 14: 425-33. PMID 22102629 DOI: 10.1093/ntr/ntr231  1
2012 Haller G, Druley T, Vallania FL, Mitra RD, Li P, Akk G, Steinbach JH, Breslau N, Johnson E, Hatsukami D, Stitzel J, Bierut LJ, Goate AM. Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence. Human Molecular Genetics. 21: 647-55. PMID 22042774 DOI: 10.1093/hmg/ddr498  1
2012 Gerrish A, Russo G, Richards A, Moskvina V, Ivanov D, Harold D, Sims R, Abraham R, Hollingworth P, Chapman J, Hamshere M, Pahwa JS, Dowzell K, Williams A, Jones N, ... ... Goate AM, et al. The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 28: 377-87. PMID 22027014 DOI: 10.3233/JAD-2011-110824  1
2012 Bierut LJ, Goate AM, Breslau N, Johnson EO, Bertelsen S, Fox L, Agrawal A, Bucholz KK, Grucza R, Hesselbrock V, Kramer J, Kuperman S, Nurnberger J, Porjesz B, Saccone NL, et al. ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry. Molecular Psychiatry. 17: 445-50. PMID 21968928 DOI: 10.1038/mp.2011.124  1
2011 Vlassenko AG, Mintun MA, Xiong C, Sheline YI, Goate AM, Benzinger TL, Morris JC. Amyloid-beta plaque growth in cognitively normal adults: longitudinal [11C]Pittsburgh compound B data. Annals of Neurology. 70: 857-61. PMID 22162065 DOI: 10.1002/ana.22608  1
2011 Cruchaga C, Nowotny P, Kauwe JS, Ridge PG, Mayo K, Bertelsen S, Hinrichs A, Fagan AM, Holtzman DM, Morris JC, Goate AM. Association and expression analyses with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease. Archives of Neurology. 68: 1013-9. PMID 21825236 DOI: 10.1001/archneurol.2011.155  1
2011 Lin P, Hartz SM, Wang JC, Krueger RF, Foroud TM, Edenberg HJ, Nurnberger JI, Brooks AI, Tischfield JA, Almasy L, Webb BT, Hesselbrock VM, Porjesz B, Goate AM, Bierut LJ, et al. Copy number variation accuracy in genome-wide association studies. Human Heredity. 71: 141-7. PMID 21778733 DOI: 10.1159/000324683  1
2011 Castellano JM, Kim J, Stewart FR, Jiang H, DeMattos RB, Patterson BW, Fagan AM, Morris JC, Mawuenyega KG, Cruchaga C, Goate AM, Bales KR, Paul SM, Bateman RJ, Holtzman DM. Human apoE isoforms differentially regulate brain amyloid-β peptide clearance. Science Translational Medicine. 3: 89ra57. PMID 21715678 DOI: 10.1126/scitranslmed.3002156  1
2011 Agrawal A, Lynskey MT, Hinrichs A, Grucza R, Saccone SF, Krueger R, Neuman R, Howells W, Fisher S, Fox L, Cloninger R, Dick DM, Doheny KF, Edenberg HJ, Goate AM, et al. A genome-wide association study of DSM-IV cannabis dependence. Addiction Biology. 16: 514-8. PMID 21668797 DOI: 10.1111/j.1369-1600.2010.00255.x  1
2011 Page T, Gitcho MA, Mosaheb S, Carter D, Chakraverty S, Perry RH, Bigio EH, Gearing M, Ferrer I, Goate AM, Cairns NJ, Thorpe JR. FUS immunogold labeling TEM analysis of the neuronal cytoplasmic inclusions of neuronal intermediate filament inclusion disease: a frontotemporal lobar degeneration with FUS proteinopathy. Journal of Molecular Neuroscience : Mn. 45: 409-21. PMID 21603978 DOI: 10.1007/s12031-011-9549-8  1
2011 Heath AC, Whitfield JB, Martin NG, Pergadia ML, Goate AM, Lind PA, McEvoy BP, Schrage AJ, Grant JD, Chou YL, Zhu R, Henders AK, Medland SE, Gordon SD, Nelson EC, et al. A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications. Biological Psychiatry. 70: 513-8. PMID 21529783 DOI: 10.1016/j.biopsych.2011.02.028  1
2011 Holtzman DM, Morris JC, Goate AM. Alzheimer's disease: the challenge of the second century. Science Translational Medicine. 3: 77sr1. PMID 21471435 DOI: 10.1126/scitranslmed.3002369  0.44
2011 Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, ... ... Goate AM, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nature Genetics. 43: 436-41. PMID 21460841 DOI: 10.1038/ng.801  0.8
2011 Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards A, ... ... Goate AM, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nature Genetics. 43: 429-35. PMID 21460840 DOI: 10.1038/ng.803  1
2011 Wijsman EM, Pankratz ND, Choi Y, Rothstein JH, Faber KM, Cheng R, Lee JH, Bird TD, Bennett DA, Diaz-Arrastia R, Goate AM, Farlow M, Ghetti B, Sweet RA, Foroud TM, et al. Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE. Plos Genetics. 7: e1001308. PMID 21379329 DOI: 10.1371/journal.pgen.1001308  1
2011 Kauwe JS, Cruchaga C, Karch CM, Sadler B, Lee M, Mayo K, Latu W, Su'a M, Fagan AM, Holtzman DM, Morris JC, Goate AM. Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease. Plos One. 6: e15918. PMID 21347408 DOI: 10.1371/journal.pone.0015918  1
2011 Ringman JM, Gylys KH, Medina LD, Fox M, Kepe V, Flores DL, Apostolova LG, Barrio JR, Small G, Silverman DH, Siu E, Cederbaum S, Hecimovic S, Malnar M, Chakraverty S, ... Goate AM, et al. Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation. Neuroscience Letters. 487: 287-92. PMID 21094210 DOI: 10.1016/j.neulet.2010.10.039  1
2011 Culverhouse RC, Saccone NL, Stitzel JA, Wang JC, Steinbach JH, Goate AM, Schwantes-An TH, Grucza RA, Stevens VL, Bierut LJ. Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence. Human Genetics. 129: 177-88. PMID 21079997 DOI: 10.1007/s00439-010-0911-7  1
2011 Lenze EJ, Mantella RC, Shi P, Goate AM, Nowotny P, Butters MA, Andreescu C, Thompson PA, Rollman BL. Elevated cortisol in older adults with generalized anxiety disorder is reduced by treatment: a placebo-controlled evaluation of escitalopram. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. 19: 482-90. PMID 20808146 DOI: 10.1097/JGP.0b013e3181ec806c  1
2011 Ringman JM, Gylys KH, Medina LD, Fox M, Kepe V, Flores DL, Apostolova LG, Barrio JR, Small G, Silverman DH, Siu E, Cederbaum S, Hecimovic S, Malnar M, Chakraverty S, ... Goate AM, et al. Corrigendum to " Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation" [Neurosci. Lett. 487 (2011) 287-292] Neuroscience Letters. 491: 163. DOI: 10.1016/j.neulet.2011.01.021  1
2010 Gao X, Joselin AP, Wang L, Kar A, Ray P, Bateman A, Goate AM, Wu JY. Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β. Protein & Cell. 1: 552-62. PMID 21204008 DOI: 10.1007/s13238-010-0067-1  1
2010 Lenze EJ, Goate AM, Nowotny P, Dixon D, Shi P, Bies RR, Lotrich FK, Rollman BL, Shear MK, Thompson PA, Andreescu C, Pollock BG. Relation of serotonin transporter genetic variation to efficacy of escitalopram for generalized anxiety disorder in older adults. Journal of Clinical Psychopharmacology. 30: 672-7. PMID 21105279 DOI: 10.1097/JCP.0b013e3181fc2bef  1
2010 Jones L, Holmans PA, Hamshere ML, Harold D, Moskvina V, Ivanov D, Pocklington A, Abraham R, Hollingworth P, Sims R, Gerrish A, Pahwa JS, Jones N, Stretton A, Morgan AR, ... ... Goate AM, et al. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. Plos One. 5: e13950. PMID 21085570 DOI: 10.1371/journal.pone.0013950  1
2010 Cruchaga C, Kauwe JS, Mayo K, Spiegel N, Bertelsen S, Nowotny P, Shah AR, Abraham R, Hollingworth P, Harold D, Owen MM, Williams J, Lovestone S, Peskind ER, Li G, ... ... Goate AM, et al. SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease. Plos Genetics. 6: e1001101. PMID 20862329 DOI: 10.1371/journal.pgen.1001101  1
2010 Liang KY, Mintun MA, Fagan AM, Goate AM, Bugg JM, Holtzman DM, Morris JC, Head D. Exercise and Alzheimer's disease biomarkers in cognitively normal older adults. Annals of Neurology. 68: 311-8. PMID 20818789 DOI: 10.1002/ana.22096  1
2010 Jun G, Naj AC, Beecham GW, Wang LS, Buros J, Gallins PJ, Buxbaum JD, Ertekin-Taner N, Fallin MD, Friedland R, Inzelberg R, Kramer P, Rogaeva E, St George-Hyslop P, ... ... Goate AM, et al. Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes. Archives of Neurology. 67: 1473-84. PMID 20697030 DOI: 10.1001/archneurol.2010.201  1
2010 Kauwe JS, Cruchaga C, Bertelsen S, Mayo K, Latu W, Nowotny P, Hinrichs AL, Fagan AM, Holtzman DM, Goate AM. Validating predicted biological effects of Alzheimer's disease associated SNPs using CSF biomarker levels. Journal of Alzheimer's Disease : Jad. 21: 833-42. PMID 20634593 DOI: 10.3233/JAD-2010-091711  1
2010 Saccone NL, Schwantes-An TH, Wang JC, Grucza RA, Breslau N, Hatsukami D, Johnson EO, Rice JP, Goate AM, Bierut LJ. Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. Genes, Brain, and Behavior. 9: 741-50. PMID 20584212 DOI: 10.1111/j.1601-183X.2010.00608.x  1
2010 Lin P, Hartz SM, Zhang Z, Saccone SF, Wang J, Tischfield JA, Edenberg HJ, Kramer JR, M Goate A, Bierut LJ, Rice JP. A new statistic to evaluate imputation reliability. Plos One. 5: e9697. PMID 20300623 DOI: 10.1371/journal.pone.0009697  1
2010 Bierut LJ, Agrawal A, Bucholz KK, Doheny KF, Laurie C, Pugh E, Fisher S, Fox L, Howells W, Bertelsen S, Hinrichs AL, Almasy L, Breslau N, Culverhouse RC, Dick DM, ... ... Goate AM, et al. A genome-wide association study of alcohol dependence. Proceedings of the National Academy of Sciences of the United States of America. 107: 5082-7. PMID 20202923 DOI: 10.1073/pnas.0911109107  1
2010 Morris JC, Roe CM, Xiong C, Fagan AM, Goate AM, Holtzman DM, Mintun MA. APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging. Annals of Neurology. 67: 122-31. PMID 20186853 DOI: 10.1002/ana.21843  1
2010 Kauwe JS, Bertelsen S, Mayo K, Cruchaga C, Abraham R, Hollingworth P, Harold D, Owen MJ, Williams J, Lovestone S, Morris JC, Goate AM. Suggestive synergy between genetic variants in TF and HFE as risk factors for Alzheimer's disease. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 153: 955-9. PMID 20029940 DOI: 10.1002/ajmg.b.31053  1
2010 Edwards AC, Dodge KA, Latendresse SJ, Lansford JE, Bates JE, Pettit GS, Budde JP, Goate AM, Dick DM. MAOA-uVNTR and early physical discipline interact to influence delinquent behavior. Journal of Child Psychology and Psychiatry, and Allied Disciplines. 51: 679-87. PMID 19951362 DOI: 10.1111/j.1469-7610.2009.02196.x  1
2010 Hinrichs AL, Mintun MA, Head D, Fagan AM, Holtzman DM, Morris JC, Goate AM. Cortical binding of pittsburgh compound B, an endophenotype for genetic studies of Alzheimer's disease. Biological Psychiatry. 67: 581-3. PMID 19892322 DOI: 10.1016/j.biopsych.2009.09.012  1
2010 Nelson EC, Agrawal A, Pergadia ML, Wang JC, Whitfield JB, Saccone FS, Kern J, Grant JD, Schrage AJ, Rice JP, Montgomery GW, Heath AC, Goate AM, Martin NG, Madden PA. H2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependence. Addiction Biology. 15: 1-11. PMID 19878140 DOI: 10.1111/j.1369-1600.2009.00181.x  1
2009 Chen LS, Johnson EO, Breslau N, Hatsukami D, Saccone NL, Grucza RA, Wang JC, Hinrichs AL, Fox L, Goate AM, Rice JP, Bierut LJ. Interplay of Genetic Risk Factors and Parent Monitoring in Risk for Nicotine Dependence. Addiction (Abingdon, England). 104: 1731-1740. PMID 20871796 DOI: 10.1111/j.1360-0443.2009.02697.x  1
2009 Morris JC, Roe CM, Grant EA, Head D, Storandt M, Goate AM, Fagan AM, Holtzman DM, Mintun MA. Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease. Archives of Neurology. 66: 1469-75. PMID 20008650 DOI: 10.1001/archneurol.2009.269  1
2009 Duchek JM, Balota DA, Tse CS, Holtzman DM, Fagan AM, Goate AM. The utility of intraindividual variability in selective attention tasks as an early marker for Alzheimer's disease. Neuropsychology. 23: 746-58. PMID 19899833 DOI: 10.1037/a0016583  1
2009 Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, ... ... Goate AM, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nature Genetics. 41: 1088-93. PMID 19734902 DOI: 10.1038/ng.440  0.88
2009 Wang JC, Bierut LJ, Goate AM. Variants weakly correlated with CHRNA5 D398N polymorphism should be considered in transcriptional deregulation at the 15q25 locus associated with lung cancer risk. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 5599; author reply 5. PMID 19706810 DOI: 10.1158/1078-0432.CCR-09-1108  1
2009 Saccone NL, Wang JC, Breslau N, Johnson EO, Hatsukami D, Saccone SF, Grucza RA, Sun L, Duan W, Budde J, Culverhouse RC, Fox L, Hinrichs AL, Steinbach JH, Wu M, ... ... Goate AM, et al. The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Cancer Research. 69: 6848-56. PMID 19706762 DOI: 10.1158/0008-5472.CAN-09-0786  1
2009 Fenoglio C, Galimberti D, Cortini F, Kauwe JS, Cruchaga C, Venturelli E, Villa C, Serpente M, Scalabrini D, Mayo K, Piccio LM, Clerici F, Albani D, Mariani C, Forloni G, ... ... Goate AM, et al. Rs5848 variant influences GRN mRNA levels in brain and peripheral mononuclear cells in patients with Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 18: 603-12. PMID 19625741 DOI: 10.3233/JAD-2009-1170  1
2009 Gitcho MA, Bigio EH, Mishra M, Johnson N, Weintraub S, Mesulam M, Rademakers R, Chakraverty S, Cruchaga C, Morris JC, Goate AM, Cairns NJ. TARDBP 3'-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy. Acta Neuropathologica. 118: 633-45. PMID 19618195 DOI: 10.1007/s00401-009-0571-7  1
2009 Wang JC, Cruchaga C, Saccone NL, Bertelsen S, Liu P, Budde JP, Duan W, Fox L, Grucza RA, Kern J, Mayo K, Reyes O, Rice J, Saccone SF, Spiegel N, ... ... Goate AM, et al. Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. Human Molecular Genetics. 18: 3125-35. PMID 19443489 DOI: 10.1093/hmg/ddp231  1
2009 Lester HA, Xiao C, Srinivasan R, Son CD, Miwa J, Pantoja R, Banghart MR, Dougherty DA, Goate AM, Wang JC. Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery. The Aaps Journal. 11: 167-77. PMID 19280351 DOI: 10.1208/s12248-009-9090-7  1
2009 Saccone NL, Saccone SF, Hinrichs AL, Stitzel JA, Duan W, Pergadia ML, Agrawal A, Breslau N, Grucza RA, Hatsukami D, Johnson EO, Madden PA, Swan GE, Wang JC, Goate AM, et al. Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 150: 453-66. PMID 19259974 DOI: 10.1002/ajmg.b.30828  1
2009 Gitcho MA, Strider J, Carter D, Taylor-Reinwald L, Forman MS, Goate AM, Cairns NJ. VCP mutations causing frontotemporal lobar degeneration disrupt localization of TDP-43 and induce cell death. The Journal of Biological Chemistry. 284: 12384-98. PMID 19237541 DOI: 10.1074/jbc.M900992200  1
2009 Nelson EC, Agrawal A, Pergadia ML, Lynskey MT, Todorov AA, Wang JC, Todd RD, Martin NG, Heath AC, Goate AM, Montgomery GW, Madden PA. Association of childhood trauma exposure and GABRA2 polymorphisms with risk of posttraumatic stress disorder in adults. Molecular Psychiatry. 14: 234-5. PMID 19229201 DOI: 10.1038/mp.2008.81  1
2009 Agrawal A, Pergadia ML, Balasubramanian S, Saccone SF, Hinrichs AL, Saccone NL, Breslau N, Johnson EO, Hatsukami D, Martin NG, Montgomery GW, Goate AM, Rice JP, Bierut LJ, Madden PA. Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine Dependence. Addiction (Abingdon, England). 104: 471-7. PMID 19207358 DOI: 10.1111/j.1360-0443.2008.02445.x  1
2009 Pergadia ML, Agrawal A, Loukola A, Montgomery GW, Broms U, Saccone SF, Wang JC, Todorov AA, Heikkilä K, Statham DJ, Henders AK, Campbell MJ, Rice JP, Todd RD, Heath AC, ... Goate AM, et al. Genetic linkage findings for DSM-IV nicotine withdrawal in two populations. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 150: 950-9. PMID 19180564 DOI: 10.1002/ajmg.b.30924  1
2009 Kauwe JS, Wang J, Mayo K, Morris JC, Fagan AM, Holtzman DM, Goate AM. Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta. Neurogenetics. 10: 13-7. PMID 18813964 DOI: 10.1007/s10048-008-0150-4  1
2009 Wang JC, Grucza R, Cruchaga C, Hinrichs AL, Bertelsen S, Budde JP, Fox L, Goldstein E, Reyes O, Saccone N, Saccone S, Xuei X, Bucholz K, Kuperman S, Nurnberger J, ... ... Goate AM, et al. Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence. Molecular Psychiatry. 14: 501-10. PMID 18414406 DOI: 10.1038/mp.2008.42  1
2008 Saccone NL, Saccone SF, Goate AM, Grucza RA, Hinrichs AL, Rice JP, Bierut LJ. In search of causal variants: refining disease association signals using cross-population contrasts. Bmc Genetics. 9: 58. PMID 18759969 DOI: 10.1186/1471-2156-9-58  1
2008 Hogue CW, Fucetola R, Hershey T, Freedland K, Dávila-Román VG, Goate AM, Thompson RE. Risk factors for neurocognitive dysfunction after cardiac surgery in postmenopausal women. The Annals of Thoracic Surgery. 86: 511-6. PMID 18640325 DOI: 10.1016/j.athoracsur.2008.04.058  1
2008 Saccone SF, Saccone NL, Swan GE, Madden PA, Goate AM, Rice JP, Bierut LJ. Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence. Bioinformatics (Oxford, England). 24: 1805-11. PMID 18565990 DOI: 10.1093/bioinformatics/btn315  1
2008 Kauwe JS, Cruchaga C, Mayo K, Fenoglio C, Bertelsen S, Nowotny P, Galimberti D, Scarpini E, Morris JC, Fagan AM, Holtzman DM, Goate AM. Variation in MAPT is associated with cerebrospinal fluid tau levels in the presence of amyloid-beta deposition. Proceedings of the National Academy of Sciences of the United States of America. 105: 8050-4. PMID 18541914 DOI: 10.1073/pnas.0801227105  1
2008 Agrawal A, Pergadia ML, Saccone SF, Lynskey MT, Wang JC, Martin NG, Statham D, Henders A, Campbell M, Garcia R, Broms U, Todd RD, Goate AM, Rice J, Kaprio J, et al. An autosomal linkage scan for cannabis use disorders in the nicotine addiction genetics project. Archives of General Psychiatry. 65: 713-21. PMID 18519829 DOI: 10.1001/archpsyc.65.6.713  1
2008 Bierut LJ, Stitzel JA, Wang JC, Hinrichs AL, Grucza RA, Xuei X, Saccone NL, Saccone SF, Bertelsen S, Fox L, Horton WJ, Breslau N, Budde J, Cloninger CR, Dick DM, ... ... Goate AM, et al. Variants in nicotinic receptors and risk for nicotine dependence. The American Journal of Psychiatry. 165: 1163-71. PMID 18519524 DOI: 10.1176/appi.ajp.2008.07111711  1
2008 Grucza RA, Wang JC, Stitzel JA, Hinrichs AL, Saccone SF, Saccone NL, Bucholz KK, Cloninger CR, Neuman RJ, Budde JP, Fox L, Bertelsen S, Kramer J, Hesselbrock V, Tischfield J, ... ... Goate AM, et al. A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence. Biological Psychiatry. 64: 922-9. PMID 18519132 DOI: 10.1016/j.biopsych.2008.04.018  1
2008 Agrawal A, Pergadia ML, Saccone SF, Hinrichs AL, Lessov-Schlaggar CN, Saccone NL, Neuman RJ, Breslau N, Johnson E, Hatsukami D, Montgomery GW, Heath AC, Martin NG, Goate AM, Rice JP, et al. Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control study. Addiction (Abingdon, England). 103: 1027-38. PMID 18482426 DOI: 10.1111/j.1360-0443.2008.02236.x  1
2008 Kauwe JS, Wang J, Chakraverty S, Goate AM, Henao-Martinez AF. Novel presenilin 1 variant (P117A) causing Alzheimer's disease in the fourth decade of life. Neuroscience Letters. 438: 257-9. PMID 18479822 DOI: 10.1016/j.neulet.2008.04.029  1
2008 Gitcho MA, Baloh RH, Chakraverty S, Mayo K, Norton JB, Levitch D, Hatanpaa KJ, White CL, Bigio EH, Caselli R, Baker M, Al-Lozi MT, Morris JC, Pestronk A, Rademakers R, ... Goate AM, et al. TDP-43 A315T mutation in familial motor neuron disease. Annals of Neurology. 63: 535-8. PMID 18288693 DOI: 10.1002/ana.21344  1
2008 Agrawal A, Hinrichs AL, Dunn G, Bertelsen S, Dick DM, Saccone SF, Saccone NL, Grucza RA, Wang JC, Cloninger CR, Edenberg HJ, Foroud T, Hesselbrock V, Kramer J, Bucholz KK, ... ... Goate AM, et al. Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample. Drug and Alcohol Dependence. 93: 12-20. PMID 17942244 DOI: 10.1016/j.drugalcdep.2007.08.015  1
2007 Hu Y, Hosseini A, Kauwe JS, Gross J, Cairns NJ, Goate AM, Fagan AM, Townsend RR, Holtzman DM. Identification and validation of novel CSF biomarkers for early stages of Alzheimer's disease. Proteomics. Clinical Applications. 1: 1373-84. PMID 21136637 DOI: 10.1002/prca.200600999  1
2007 Cairns NJ, Neumann M, Bigio EH, Holm IE, Troost D, Hatanpaa KJ, Foong C, White CL, Schneider JA, Kretzschmar HA, Carter D, Taylor-Reinwald L, Paulsmeyer K, Strider J, Gitcho M, ... Goate AM, et al. TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions. The American Journal of Pathology. 171: 227-40. PMID 17591968 DOI: 10.2353/ajpath.2007.070182  1
2007 Saccone SF, Pergadia ML, Loukola A, Broms U, Montgomery GW, Wang JC, Agrawal A, Dick DM, Heath AC, Todorov AA, Maunu H, Heikkila K, Morley KI, Rice JP, Todd RD, ... ... Goate AM, et al. Genetic linkage to chromosome 22q12 for a heavy-smoking quantitative trait in two independent samples. American Journal of Human Genetics. 80: 856-66. PMID 17436240 DOI: 10.1086/513703  1
2007 Wahrle SE, Shah AR, Fagan AM, Smemo S, Kauwe JS, Grupe A, Hinrichs A, Mayo K, Jiang H, Thal LJ, Goate AM, Holtzman DM. Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1 polymorphisms. Molecular Neurodegeneration. 2: 7. PMID 17430597 DOI: 10.1186/1750-1326-2-7  1
2007 Kauwe JS, Jacquart S, Chakraverty S, Wang J, Mayo K, Fagan AM, Holtzman DM, Morris JC, Goate AM. Extreme cerebrospinal fluid amyloid beta levels identify family with late-onset Alzheimer's disease presenilin 1 mutation. Annals of Neurology. 61: 446-53. PMID 17366635 DOI: 10.1002/ana.21099  1
2007 Behrens MI, Mukherjee O, Tu PH, Liscic RM, Grinberg LT, Carter D, Paulsmeyer K, Taylor-Reinwald L, Gitcho M, Norton JB, Chakraverty S, Goate AM, Morris JC, Cairns NJ. Neuropathologic heterogeneity in HDDD1: a familial frontotemporal lobar degeneration with ubiquitin-positive inclusions and progranulin mutation. Alzheimer Disease and Associated Disorders. 21: 1-7. PMID 17334266 DOI: 10.1097/WAD.0b013e31803083f2  1
2007 Mukherjee O, Kauwe JS, Mayo K, Morris JC, Goate AM. Haplotype-based association analysis of the MAPT locus in late onset Alzheimer's disease. Bmc Genetics. 8: 3. PMID 17266761 DOI: 10.1186/1471-2156-8-3  1
2007 Wang JC, Hinrichs AL, Bertelsen S, Stock H, Budde JP, Dick DM, Bucholz KK, Rice J, Saccone N, Edenberg HJ, Hesselbrock V, Kuperman S, Schuckit MA, Bierut LJ, Goate AM. Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin. Alcoholism, Clinical and Experimental Research. 31: 209-15. PMID 17250611 DOI: 10.1111/j.1530-0277.2006.00297.x  1
2007 Bierut LJ, Madden PA, Breslau N, Johnson EO, Hatsukami D, Pomerleau OF, Swan GE, Rutter J, Bertelsen S, Fox L, Fugman D, Goate AM, Hinrichs AL, Konvicka K, Martin NG, et al. Novel genes identified in a high-density genome wide association study for nicotine dependence. Human Molecular Genetics. 16: 24-35. PMID 17158188 DOI: 10.1093/hmg/ddl441  1
2007 Saccone SF, Hinrichs AL, Saccone NL, Chase GA, Konvicka K, Madden PA, Breslau N, Johnson EO, Hatsukami D, Pomerleau O, Swan GE, Goate AM, Rutter J, Bertelsen S, Fox L, et al. Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Human Molecular Genetics. 16: 36-49. PMID 17135278 DOI: 10.1093/hmg/ddl438  1
2006 Mukherjee O, Pastor P, Cairns NJ, Chakraverty S, Kauwe JS, Shears S, Behrens MI, Budde J, Hinrichs AL, Norton J, Levitch D, Taylor-Reinwald L, Gitcho M, Tu PH, Tenenholz Grinberg L, ... ... Goate AM, et al. HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin. Annals of Neurology. 60: 314-22. PMID 16983685 DOI: 10.1002/ana.20963  1
2006 Hinrichs AL, Wang JC, Bufe B, Kwon JM, Budde J, Allen R, Bertelsen S, Evans W, Dick D, Rice J, Foroud T, Nurnberger J, Tischfield JA, Kuperman S, Crowe R, ... ... Goate AM, et al. Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence. American Journal of Human Genetics. 78: 103-11. PMID 16385453 DOI: 10.1086/499253  1
2005 Snider BJ, Norton J, Coats MA, Chakraverty S, Hou CE, Jervis R, Lendon CL, Goate AM, McKeel DW, Morris JC. Novel presenilin 1 mutation (S170F) causing Alzheimer disease with Lewy bodies in the third decade of life. Archives of Neurology. 62: 1821-30. PMID 16344340 DOI: 10.1001/archneur.62.12.1821  1
2005 Brunkan AL, Martinez M, Wang J, Walker ES, Beher D, Shearman MS, Goate AM. Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and gamma-secretase activity. Journal of Neurochemistry. 94: 1315-28. PMID 16001967 DOI: 10.1111/j.1471-4159.2005.03278.x  1
2005 Brunkan AL, Martinez M, Walker ES, Goate AM. Presenilin endoproteolysis is an intramolecular cleavage. Molecular and Cellular Neurosciences. 29: 65-73. PMID 15866047 DOI: 10.1016/j.mcn.2004.12.012  1
2005 Brunkan AL, Goate AM. Presenilin function and gamma-secretase activity. Journal of Neurochemistry. 93: 769-92. PMID 15857382 DOI: 10.1111/j.1471-4159.2005.03099.x  1
2005 Brunkan AL, Martinez M, Wang J, Walker ES, Goate AM. A domain at the C-terminus of PS1 is required for presenilinase and gamma-secretase activities. Journal of Neurochemistry. 92: 1158-69. PMID 15715666 DOI: 10.1111/j.1471-4159.2004.02945.x  1
2004 Hecimovic S, Wang J, Dolios G, Martinez M, Wang R, Goate AM. Mutations in APP have independent effects on Abeta and CTFgamma generation. Neurobiology of Disease. 17: 205-18. PMID 15474359 DOI: 10.1016/j.nbd.2004.04.018  1
2004 Pastor P, Ezquerra M, Perez JC, Chakraverty S, Norton J, Racette BA, McKeel D, Perlmutter JS, Tolosa E, Goate AM. Novel haplotypes in 17q21 are associated with progressive supranuclear palsy. Annals of Neurology. 56: 249-58. PMID 15293277 DOI: 10.1002/ana.20178  1
2004 Wang JC, Hinrichs AL, Stock H, Budde J, Allen R, Bertelsen S, Kwon JM, Wu W, Dick DM, Rice J, Jones K, Nurnberger JI, Tischfield J, Porjesz B, Edenberg HJ, ... ... Goate AM, et al. Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome. Human Molecular Genetics. 13: 1903-11. PMID 15229186 DOI: 10.1093/hmg/ddh194  1
2004 Pastor P, Goate AM. Molecular genetics of Alzheimer's disease. Current Psychiatry Reports. 6: 125-33. PMID 15038915  1
2003 McInnis MG, Dick DM, Willour VL, Avramopoulos D, MacKinnon DF, Simpson SG, Potash JB, Edenberg HJ, Bowman ES, McMahon FJ, Smiley C, Chellis JL, Huo Y, Diggs T, Meyer ET, ... ... Goate AM, et al. Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigrees. Biological Psychiatry. 54: 1265-73. PMID 14643094 DOI: 10.1016/j.biopsych.2003.08.001  1
2003 Pastor P, Roe CM, Villegas A, Bedoya G, Chakraverty S, García G, Tirado V, Norton J, Ríos S, Martínez M, Kosik KS, Lopera F, Goate AM. Apolipoprotein Eepsilon4 modifies Alzheimer's disease onset in an E280A PS1 kindred. Annals of Neurology. 54: 163-9. PMID 12891668 DOI: 10.1002/ana.10636  1
2002 Lambert JC, Araria-Goumidi L, Myllykangas L, Ellis C, Wang JC, Bullido MJ, Harris JM, Artiga MJ, Hernandez D, Kwon JM, Frigard B, Petersen RC, Cumming AM, Pasquier F, Sastre I, ... ... Goate AM, et al. Contribution of APOE promoter polymorphisms to Alzheimer's disease risk. Neurology. 59: 59-66. PMID 12105308  1
2001 Nowotny P, Kwon JM, Goate AM. SNP analysis to dissect human traits. Current Opinion in Neurobiology. 11: 637-41. PMID 11595500 DOI: 10.1016/S0959-4388(00)00261-0  1
2001 Myers AJ, Goate AM. The genetics of late-onset Alzheimer's disease. Current Opinion in Neurology. 14: 433-40. PMID 11470958 DOI: 10.1097/00019052-200108000-00002  1
2001 Nowotny P, Kwon JM, Chakraverty S, Nowotny V, Morris JC, Goate AM. Association studies using novel polymorphisms in BACE1 and BACE2. Neuroreport. 12: 1799-802. PMID 11435901  1
2001 Wu WS, Goate A, Meyer D, Kwon J, Hinrichs A, Reich T, Bierut L, Saccone N, Rice J, Li TK, Hesselbrock V, Crowe R, Schuckit M, Begleiter H, Goate AM. Analysis of variation in the protein kinase C-epsilon gene in the COGA study American Journal of Medical Genetics - Neuropsychiatric Genetics. 105: 629.  1
2001 Kwon JM, Wu W, Meyers D, Stock H, Hinrichs AL, Miller R, Goate AM. Candidate gene analysis of alcoholism and related phenotypes American Journal of Medical Genetics - Neuropsychiatric Genetics. 105: 567.  1
2000 Kwon JM, Goate AM. The candidate gene approach. Alcohol Research & Health : the Journal of the National Institute On Alcohol Abuse and Alcoholism. 24: 164-8. PMID 11199286  1
2000 Myers A, Holmans P, Marshall H, Kwon J, Meyer D, Ramic D, Shears S, Booth J, DeVrieze FW, Crook R, Hamshere M, Abraham R, Tunstall N, Rice F, Carty S, ... ... Goate AM, et al. Susceptibility locus for Alzheimer's disease on chromosome 10. Science (New York, N.Y.). 290: 2304-5. PMID 11125144 DOI: 10.1126/science.290.5500.2304  1
2000 Rosselli MC, Ardila AC, Moreno SC, Standish VC, Arango-Lasprilla JC, Tirado VM, Ossa JM, Goate AM, Kosik KS, Lopera F. Cognitive decline in patients with familial Alzheimer's disease associated with E280a presenilin-1 mutation: a longitudinal study. Journal of Clinical and Experimental Neuropsychology. 22: 483-95. PMID 10923058 DOI: 10.1076/1380-3395(200008)22:4;1-0;FT483  1
2000 Xia W, Ray WJ, Ostaszewski BL, Rahmati T, Kimberly WT, Wolfe MS, Zhang J, Goate AM, Selkoe DJ. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation. Proceedings of the National Academy of Sciences of the United States of America. 97: 9299-304. PMID 10922078 DOI: 10.1073/pnas.97.16.9299  1
2000 Jiang Z, Cote J, Kwon JM, Goate AM, Wu JY. Aberrant splicing of tau pre-mRNA caused by intronic mutations associated with the inherited dementia frontotemporal dementia with parkinsonism linked to chromosome 17. Molecular and Cellular Biology. 20: 4036-48. PMID 10805746 DOI: 10.1128/MCB.20.11.4036-4048.2000  1
2000 Kwon JM, Nowotny P, Shah PK, Chakraverty S, Norton J, Morris JC, Goate AM. Tau polymorphisms are not associated with Alzheimer's disease. Neuroscience Letters. 284: 77-80. PMID 10771166 DOI: 10.1016/S0304-3940(00)00972-1  1
2000 Nowotny P, Gorski SM, Han SW, Philips K, Ray WJ, Nowotny V, Jones CJ, Clark RF, Cagan RL, Goate AM. Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin. Molecular and Cellular Neurosciences. 15: 88-98. PMID 10662508 DOI: 10.1006/mcne.1999.0805  1
2000 Ray WJ, Goate AM. 34. The genetics of Alzheimer's disease Facts, Research and Intervention in Geriatrics. 2000: 441-451.  1
1999 Ray WJ, Yao M, Mumm J, Schroeter EH, Saftig P, Wolfe M, Selkoe DJ, Kopan R, Goate AM. Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch. The Journal of Biological Chemistry. 274: 36801-7. PMID 10593990 DOI: 10.1074/jbc.274.51.36801  1
1999 Ray WJ, Yao M, Nowotny P, Mumm J, Zhang W, Wu JY, Kopan R, Goate AM. Evidence for a physical interaction between presenilin and Notch. Proceedings of the National Academy of Sciences of the United States of America. 96: 3263-8. PMID 10077672 DOI: 10.1073/pnas.96.6.3263  1
1998 Aronsson FC, Magnusson P, Andersson B, Karsten SL, Shibasaki Y, Lendon CL, Goate AM, Brookes AJ. The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17. Human Genetics. 103: 340-5. PMID 9799091 DOI: 10.1007/s004390050827  1
1998 Goate AM. Monogenetic determinants of Alzheimer's disease: APP mutations. Cellular and Molecular Life Sciences : Cmls. 54: 897-901. PMID 9791531 DOI: 10.1007/s000180050218  1
1998 Hellman NE, Grant EA, Goate AM. Failure to replicate a protective effect of allele 2 of NACP/alpha-synuclein polymorphism in Alzheimer's disease: an association study. Annals of Neurology. 44: 278-81. PMID 9708555 DOI: 10.1002/ana.410440223  1
1998 Goate AM, Edenberg HJ. The genetics of alcoholism. Current Opinion in Genetics & Development. 8: 282-6. PMID 9691005 DOI: 10.1016/S0959-437X(98)80082-8  1
1998 Malin SA, Guo WX, Jafari G, Goate AM, Nerbonne JM. Presenilins upregulate functional K+ channel currents in mammalian cells. Neurobiology of Disease. 4: 398-409. PMID 9666479 DOI: 10.1006/nbdi.1998.0167  1
1998 Lendon CL, Lynch T, Norton J, McKeel DW, Busfield F, Craddock N, Chakraverty S, Gopalakrishnan G, Shears SD, Grimmett W, Wilhelmsen KC, Hansen L, Morris JC, Goate AM. Hereditary dysphasic disinhibition dementia: a frontotemporal dementia linked to 17q21-22. Neurology. 50: 1546-55. PMID 9633693  1
1998 Ray WJ, Ashall F, Goate AM. Molecular pathogenesis of sporadic and familial forms of Alzheimer's disease. Molecular Medicine Today. 4: 151-7. PMID 9572056 DOI: 10.1016/S1357-4310(98)01229-5  1
1998 Berg L, McKeel DW, Miller JP, Storandt M, Rubin EH, Morris JC, Baty J, Coats M, Norton J, Goate AM, Price JL, Gearing M, Mirra SS, Saunders AM. Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype. Archives of Neurology. 55: 326-35. PMID 9520006 DOI: 10.1001/archneur.55.3.326  1
1998 Lendon CL, Lobos E, Bullido MJ, Artiga MJ, Chakraverty S, Morris JC, Valdivieso F, Goate AM. Variation at the apolipoprotein E locus and risk for Alzheimer's disease: Cladistic analysis American Journal of Medical Genetics - Neuropsychiatric Genetics. 81: 554.  1
1998 Todd RD, Ji T, Goate AM. Prediction of APOE genotype by phenotype in Alzheimer's disease American Journal of Medical Genetics - Neuropsychiatric Genetics. 81: 554.  1
1997 Goate AM, Morris JC. Notch3 mutations and the potential for diagnostic testing for CADASIL. Lancet. 350: 1490. PMID 9388391 DOI: 10.1016/S0140-6736(97)22047-7  1
1997 Goate AM. Molecular genetics of Alzheimer's disease. Geriatrics. 52: S9-12. PMID 9307578  1
1997 Lendon CL, Martinez A, Behrens IM, Kosik KS, Madrigal L, Norton J, Neuman R, Myers A, Busfield F, Wragg M, Arcos M, Arango Viana JC, Ossa J, Ruiz A, Goate AM, et al. E280A PS-1 mutation causes Alzheimer's disease but age of onset is not modified by ApoE alleles. Human Mutation. 10: 186-95. PMID 9298817 DOI: 10.1002/(SICI)1098-1004(1997)10:3<186::AID-HUMU2>3.0.CO;2-H  1
1997 Lendon CL, Myers A, Cumming A, Goate AM, St Clair D. A polymorphism in the presenilin 1 gene does not modify risk for Alzheimer's disease in a cohort with sporadic early onset. Neuroscience Letters. 228: 212-4. PMID 9218645 DOI: 10.1016/S0304-3940(97)00393-5  1
1997 Lendon CL, Talbot CJ, Craddock NJ, Han SW, Wragg M, Morris JC, Goate AM. Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population. Neuroscience Letters. 222: 187-90. PMID 9148246 DOI: 10.1016/S0304-3940(97)13381-X  1
1997 Lendon CL, Ashall F, Goate AM. Exploring the etiology of Alzheimer disease using molecular genetics. Jama. 277: 825-31. PMID 9052714  1
1997 Lopera F, Ardilla A, Martínez A, Madrigal L, Arango-Viana JC, Lemere CA, Arango-Lasprilla JC, Hincapíe L, Arcos-Burgos M, Ossa JE, Behrens IM, Norton J, Lendon C, Goate AM, Ruiz-Linares A, et al. Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutation. Jama. 277: 793-9. PMID 9052708  1
1997 Han SW, Lendon CL, Goate AM. Genetic association study between a BamHl polymorphism in exon 1 of the protectin gene and dementia of the Alzheimer's type in a Caucasian population Alzheimer's Research. 3: 275-278.  1
1996 Barton AJ, Crook BW, Karran EH, Brown F, Dewar D, Mann DM, Pearson RC, Graham DI, Hardy J, Hutton M, Duff K, Goate AM, Clark RF, Roberts GW. Alteration in brain presenilin 1 mRNA expression in early onset familial Alzheimer's disease. Neurodegeneration : a Journal For Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration. 5: 213-8. PMID 8910899 DOI: 10.1006/neur.1996.0029  1
1996 Lemere CA, Lopera F, Kosik KS, Lendon CL, Ossa J, Saido TC, Yamaguchi H, Ruiz A, Martinez A, Madrigal L, Hincapie L, Arango JC, Anthony DC, Koo EH, Goate AM, et al. The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology. Nature Medicine. 2: 1146-50. PMID 8837617 DOI: 10.1038/nm1096-1146  1
1995 Wragg MA, Talbot CJ, Morris JC, Lendon CL, Goate AM. No association found between Alzheimer's disease and a mitochondrial tRNA glutamine gene variant. Neuroscience Letters. 201: 107-10. PMID 8848229 DOI: 10.1016/0304-3940(95)12146-3  1
1995 Cruts M, Backhovens H, Theuns J, Clark RF, Le Paslier D, Weissenbach J, Goate AM, Martin JJ, Van Broeckhoven C. Genetic and physical characterization of the early-onset Alzheimer's disease AD3 locus on chromosome 14q24.3. Human Molecular Genetics. 4: 1355-64. PMID 7581374 DOI: 10.1093/hmg/4.8.1355  1
1995 Clark RF, Cruts M, Korenblat KM, He C, Talbot C, Van Broeckhoven C, Goate AM. A yeast artificial chromosome contig from human chromosome 14q24 spanning the Alzheimer's disease locus AD3. Human Molecular Genetics. 4: 1347-54. PMID 7581373 DOI: 10.1093/hmg/4.8.1347  1
1994 Ashall F, Goate AM. Role of the beta-amyloid precursor protein in Alzheimer's disease. Trends in Biochemical Sciences. 19: 42-6. PMID 8140621 DOI: 10.1016/0968-0004(94)90173-2  1
1993 Rooke K, Talbot C, James L, Anand R, Hardy JA, Goate AM. A physical map of the human APP gene in YACs. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 4: 662-9. PMID 8281016 DOI: 10.1007/BF00360904  1
1993 Clark RF, Goate AM. Molecular genetics of Alzheimer's disease. Archives of Neurology. 50: 1164-72. PMID 8215975 DOI: 10.1001/archneur.1993.00540110044004  1
1991 van Duijn CM, van Broeckhoven C, Hardy JA, Goate AM, Rossor MN, Vandenberghe A, Martin JJ, Hofman A, Mullan MJ. Evidence for allelic heterogeneity in familial early-onset Alzheimer's disease. The British Journal of Psychiatry : the Journal of Mental Science. 158: 471-4. PMID 2054561  1
1991 Owen MJ, Goate AM, Hardy JA. A polymorphic microsatellite repeat sequence on chromosome 21 (D21S80). Nucleic Acids Research. 19: 4574. PMID 1886795 DOI: 10.1093/nar/19.16.4574  1
1991 Mullan MJ, Giuffra L, Hardy JA, Ovenstone I, Haynes AR, James LA, Williamson R, Newton PJ, Owen MJ, Roques P. Clinical and pathologic features of chromosome 21-linked familial Alzheimer's disease. Annals of the New York Academy of Sciences. 640: 177-80. PMID 1776736  1
1991 Ashall F, Goate AM. No growth for British science [2] Nature. 350: 550.  1
1990 Goate AM, Hardy JA, Owen MJ, Haynes A, James L, Farrall M, Mullan MJ, Roques P, Rossor MN. Genetics of Alzheimer's disease. Advances in Neurology. 51: 197-8. PMID 2403711  1
1990 Owen MJ, James LA, Hardy JA, Williamson R, Goate AM. Physical mapping around the Alzheimer disease locus on the proximal long arm of chromosome 21. American Journal of Human Genetics. 46: 316-22. PMID 2301399  1
1990 Walker AP, Collins FS, Siddique T, Yamaoka LH, Herbstreith MH, Pericak-Vance MA, Secore SL, Hung WY, Goate AM, Hardy JA. D21S194, a jump clone from D21S16. Nucleic Acids Research. 18: 1931. PMID 1970875 DOI: 10.1093/nar/18.7.1931-a  0.88
1989 Hardy JA, Goate AM, Owen MJ, Mullan MJ, Rossor MN, Pearson RC. Modelling the occurrence and pathology of Alzheimer's disease. Neurobiology of Aging. 10: 429-31; discussion 4. PMID 2812201 DOI: 10.1016/0197-4580(89)90084-5  1
1989 Goate AM, Haynes AR, Owen MJ, Farrall M, James LA, Lai LY, Mullan MJ, Roques P, Rossor MN, Williamson R. Predisposing locus for Alzheimer's disease on chromosome 21. Lancet. 1: 352-5. PMID 2563508  0.88
1989 Hardy JA, Owen MJ, Goate AM, James LA, Haynes AR, Rossor MN, Roques P, Mullan MJ. Molecular genetics of Alzheimer's disease. Biochemical Society Transactions. 17: 75-6. PMID 2523829  1
1987 Cooper DN, Niemann SC, Gosden JR, Mitchell AR, Goate AM, Rajendran GS, Miller DA, Lim L, Schmidtke J. Regional localization and characterization of a DNA segment on the long arm of chromosome 21. Human Genetics. 75: 129-35. PMID 2880794 DOI: 10.1007/BF00591073  1
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