| Year |
Citation |
Score |
| 2020 |
Yoon Y, Voloudakis G, Doran N, Zhang E, Dimovasili C, Chen L, Shao Z, Darmanis S, Tang C, Tang J, Wang VX, Hof PR, Robakis NK, Georgakopoulos A. PS1 FAD mutants decrease ephrinB2-regulated angiogenic functions, ischemia-induced brain neovascularization and neuronal survival. Molecular Psychiatry. PMID 32541930 DOI: 10.1038/S41380-020-0812-7 |
0.336 |
|
| 2020 |
Zhao J, Xiao Y, Liu X, Kim S, Wu X, Barros M, Zhuang R, Hou X, Zhang Y, Robakis NK, Li YM, Dordick JS, Ubarretxena-Belandia I, Wang C. Substrate interaction inhibits γ-secretase production of amyloid-β peptides. Chemical Communications (Cambridge, England). PMID 32016207 DOI: 10.1039/C9Cc09170J |
0.335 |
|
| 2019 |
Zhao J, Xiao Y, Liu X, Kim S, Wu X, Barros M, Zhuang M, Robakis NK, Li Y, Wang C. SUBSTRATE BINDING INHIBITS γ-SECRETASE CLEAVAGE OF AMYLOID PRECURSOR PROTEIN Alzheimers & Dementia. 15: 1595. DOI: 10.1016/J.Jalz.2019.09.052 |
0.337 |
|
| 2018 |
Warren NA, Voloudakis G, Yoon Y, Robakis NK, Georgakopoulos A. The product of the γ-secretase processing of ephrinB2 regulates VE-cadherin complexes and angiogenesis. Cellular and Molecular Life Sciences : Cmls. PMID 29428965 DOI: 10.1007/S00018-018-2762-7 |
0.727 |
|
| 2017 |
Huang Q, Voloudakis G, Ren Y, Yoon Y, Zhang E, Kajiwara Y, Shao Z, Xuan Z, Lebedev D, Georgakopoulos A, Robakis NK. Presenilin1/γ-secretase protects neurons from glucose deprivation-induced death by regulating miR-212 and PEA15. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28855274 DOI: 10.1096/Fj.201700447Rr |
0.487 |
|
| 2017 |
Fullard JF, Giambartolomei C, Hauberg ME, Xu K, Voloudakis G, Shao Z, Bare C, Dudley JT, Mattheisen M, Robakis NK, Haroutunian V, Roussos P. Open chromatin profiling of human postmortem brain infers functional roles for non-coding schizophrenia loci. Human Molecular Genetics. PMID 28335009 DOI: 10.1093/Hmg/Ddx103 |
0.301 |
|
| 2016 |
Nikolakopoulou AM, Georgakopoulos A, Robakis NK. Presenilin 1 promotes trypsin-induced neuroprotection via the PAR2/ERK signaling pathway. Effects of presenilin 1 FAD mutations. Neurobiology of Aging. 42: 41-9. PMID 27143420 DOI: 10.1016/J.Neurobiolaging.2016.02.028 |
0.315 |
|
| 2015 |
Zhu L, Zhong M, Elder GA, Sano M, Holtzman DM, Gandy S, Cardozo C, Haroutunian V, Robakis NK, Cai D. Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. 112: 11965-70. PMID 26372964 DOI: 10.1073/Pnas.1510011112 |
0.335 |
|
| 2015 |
Bruban J, Voloudakis G, Huang Q, Kajiwara Y, Al Rahim M, Yoon Y, Shioi J, Gama Sosa MA, Shao Z, Georgakopoulos A, Robakis NK. Presenilin 1 is necessary for neuronal, but not glial, EGFR expression and neuroprotection via γ-secretase-independent transcriptional mechanisms. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 25985800 DOI: 10.1096/Fj.15-270645 |
0.304 |
|
| 2014 |
Robakis NK, Georgakopoulos A. Allelic interference: a mechanism for trans-dominant transmission of loss of function in the neurodegeneration of familial Alzheimer's disease. Neuro-Degenerative Diseases. 13: 126-30. PMID 24081144 DOI: 10.1159/000354241 |
0.393 |
|
| 2013 |
Zhu L, Zhong M, Zhao J, Rhee H, Caesar I, Knight EM, Volpicelli-Daley L, Bustos V, Netzer W, Liu L, Lucast L, Ehrlich ME, Robakis NK, Gandy SE, Cai D. Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model. The Journal of Biological Chemistry. 288: 32050-63. PMID 24052255 DOI: 10.1074/Jbc.M113.504365 |
0.384 |
|
| 2013 |
Xuan Z, Barthet G, Shioi J, Xu J, Georgakopoulos A, Bruban J, Robakis NK. Presenilin-1/γ-secretase controls glutamate release, tyrosine phosphorylation, and surface expression of N-methyl-D-aspartate receptor (NMDAR) subunit GluN2B. The Journal of Biological Chemistry. 288: 30495-501. PMID 24025330 DOI: 10.1074/Jbc.M113.499004 |
0.561 |
|
| 2013 |
Barthet G, Dunys J, Shao Z, Xuan Z, Ren Y, Xu J, Arbez N, Mauger G, Bruban J, Georgakopoulos A, Shioi J, Robakis NK. Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors. Neurobiology of Aging. 34: 499-510. PMID 22475621 DOI: 10.1016/J.Neurobiolaging.2012.02.024 |
0.568 |
|
| 2012 |
Barthet G, Georgakopoulos A, Robakis NK. Cellular mechanisms of γ-secretase substrate selection, processing and toxicity. Progress in Neurobiology. 98: 166-75. PMID 22622135 DOI: 10.1016/J.Pneurobio.2012.05.006 |
0.355 |
|
| 2011 |
Georgakopoulos A, Xu J, Xu C, Mauger G, Barthet G, Robakis NK. Presenilin1/gamma-secretase promotes the EphB2-induced phosphorylation of ephrinB2 by regulating phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk binding protein. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 3594-604. PMID 21746865 DOI: 10.1096/Fj.11-187856 |
0.367 |
|
| 2010 |
Pimplikar SW, Nixon RA, Robakis NK, Shen J, Tsai LH. Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 14946-54. PMID 21068297 DOI: 10.1523/Jneurosci.4305-10.2010 |
0.359 |
|
| 2009 |
Xu J, Litterst C, Georgakopoulos A, Zaganas I, Robakis NK. Peptide EphB2/CTF2 generated by the gamma-secretase processing of EphB2 receptor promotes tyrosine phosphorylation and cell surface localization of N-methyl-D-aspartate receptors. The Journal of Biological Chemistry. 284: 27220-8. PMID 19661068 DOI: 10.1074/Jbc.M109.048728 |
0.334 |
|
| 2009 |
Tezapsidis N, Johnston JM, Smith MA, Ashford JW, Casadesus G, Robakis NK, Wolozin B, Perry G, Zhu X, Greco SJ, Sarkar S. Leptin: a novel therapeutic strategy for Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 16: 731-40. PMID 19387109 DOI: 10.3233/Jad-2009-1021 |
0.47 |
|
| 2009 |
Kouchi Z, Barthet G, Serban G, Georgakopoulos A, Shioi J, Robakis NK. p120 catenin recruits cadherins to gamma-secretase and inhibits production of Abeta peptide. The Journal of Biological Chemistry. 284: 1954-61. PMID 19008223 DOI: 10.1074/Jbc.M806250200 |
0.639 |
|
| 2008 |
Baki L, Neve RL, Shao Z, Shioi J, Georgakopoulos A, Robakis NK. Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase neuroprotective signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 483-90. PMID 18184791 DOI: 10.1523/Jneurosci.4067-07.2008 |
0.307 |
|
| 2008 |
Baki L, Neve RL, Shao Z, Shioi J, Georgakopoulos A, Robakis NK. P4-195: Presenilin1 prevents neurodegeneration by stimulating PI3K/Akt neuroprotective signaling: Effects of PS1 familial Alzheimer's disease mutations Alzheimer's & Dementia. 4: T728-T728. DOI: 10.1016/J.Jalz.2008.05.2262 |
0.307 |
|
| 2007 |
Fassa A, Parisiadou L, Robakis NK, Efthimiopoulos S. Novel processing of Notch 1 within its intracellular domain by a cysteine protease. Neuro-Degenerative Diseases. 4: 148-55. PMID 17596709 DOI: 10.1159/000101839 |
0.751 |
|
| 2007 |
Litterst C, Georgakopoulos A, Shioi J, Ghersi E, Wisniewski T, Wang R, Ludwig A, Robakis NK. Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor. The Journal of Biological Chemistry. 282: 16155-63. PMID 17428795 DOI: 10.1074/Jbc.M611449200 |
0.317 |
|
| 2007 |
Shioi J, Georgakopoulos A, Mehta P, Kouchi Z, Litterst CM, Baki L, Robakis NK. FAD mutants unable to increase neurotoxic Abeta 42 suggest that mutation effects on neurodegeneration may be independent of effects on Abeta. Journal of Neurochemistry. 101: 674-81. PMID 17254019 DOI: 10.1111/J.1471-4159.2006.04391.X |
0.366 |
|
| 2006 |
Arnaud L, Robakis NK, Figueiredo-Pereira ME. It may take inflammation, phosphorylation and ubiquitination to 'tangle' in Alzheimer's disease. Neuro-Degenerative Diseases. 3: 313-9. PMID 16954650 DOI: 10.1159/000095638 |
0.352 |
|
| 2006 |
Georgakopoulos A, Litterst C, Ghersi E, Baki L, Xu C, Serban G, Robakis NK. Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling. The Embo Journal. 25: 1242-52. PMID 16511561 DOI: 10.1038/Sj.Emboj.7601031 |
0.601 |
|
| 2006 |
Georgakopoulos A, Litterst C, Ghersi E, Baki L, Xu C, Serban G, Robakis NK. O3-03-02: PS1/γ-secretase regulate the EphB-induced Src signaling Alzheimer's & Dementia. 2: S56-S57. DOI: 10.1016/J.Jalz.2006.05.206 |
0.567 |
|
| 2006 |
Shioi J, Dolcini V, Baki L, Mehta P, Georgakopoulos T, Robakis NK. P3-220: Test of PI3K/Akt signaling hypothesis for mechanism of AD using unique PS1 FAD mutations that do not affect Aβ42 production Alzheimer's & Dementia. 2: S440-S440. DOI: 10.1016/J.Jalz.2006.05.1489 |
0.312 |
|
| 2005 |
Serban G, Kouchi Z, Baki L, Georgakopoulos A, Litterst CM, Shioi J, Robakis NK. Cadherins mediate both the association between PS1 and beta-catenin and the effects of PS1 on beta-catenin stability. The Journal of Biological Chemistry. 280: 36007-12. PMID 16126725 DOI: 10.1074/Jbc.M507503200 |
0.618 |
|
| 2004 |
Wen PH, Hof PR, Chen X, Gluck K, Austin G, Younkin SG, Younkin LH, DeGasperi R, Gama Sosa MA, Robakis NK, Haroutunian V, Elder GA. The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice. Experimental Neurology. 188: 224-37. PMID 15246822 DOI: 10.1016/J.Expneurol.2004.04.002 |
0.307 |
|
| 2004 |
Serban G, Marambaud P, Litterst C, Robakis N. P3-330 γ-secretase processing of VE-cadherin regulates CBP-mediated transcription Neurobiology of Aging. 25: S449. DOI: 10.1016/S0197-4580(04)81480-5 |
0.574 |
|
| 2004 |
Marambaud P, Wen PH, Dutt A, Shioi J, Serban G, Takashima A, Siman R, Robakis NK. O3-05-02 FAD-linked presenilin-1 mutations affect the N-cadherin/CBP signaling pathway via a loss-of-function mechanism Neurobiology of Aging. 25: S61-S62. DOI: 10.1016/S0197-4580(04)80207-0 |
0.567 |
|
| 2003 |
Qin W, Ho L, Pompl PN, Peng Y, Zhao Z, Xiang Z, Robakis NK, Shioi J, Suh J, Pasinetti GM. Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity. The Journal of Biological Chemistry. 278: 50970-7. PMID 14507922 DOI: 10.1074/Jbc.M307699200 |
0.376 |
|
| 2002 |
Wen PH, Shao X, Shao Z, Hof PR, Wisniewski T, Kelley K, Friedrich VL, Ho L, Pasinetti GM, Shioi J, Robakis NK, Elder GA. Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice. Neurobiology of Disease. 10: 8-19. PMID 12079399 DOI: 10.1006/Nbdi.2002.0490 |
0.308 |
|
| 2002 |
Bussière T, Friend PD, Sadeghi N, Wicinski B, Lin GI, Bouras C, Giannakopoulos P, Robakis NK, Morrison JH, Perl DP, Hof PR. Stereologic assessment of the total cortical volume occupied by amyloid deposits and its relationship with cognitive status in aging and Alzheimer's disease. Neuroscience. 112: 75-91. PMID 12044473 DOI: 10.1016/S0306-4522(02)00056-8 |
0.314 |
|
| 2002 |
Marambaud P, Shioi J, Serban G, Georgakopoulos A, Sarner S, Nagy V, Baki L, Wen P, Efthimiopoulos S, Shao Z, Wisniewski T, Robakis NK. A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. The Embo Journal. 21: 1948-56. PMID 11953314 DOI: 10.1093/Emboj/21.8.1948 |
0.742 |
|
| 2001 |
Baki L, Marambaud P, Efthimiopoulos S, Georgakopoulos A, Wen P, Cui W, Shioi J, Koo E, Ozawa M, Friedrich VL, Robakis NK. Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex. Proceedings of the National Academy of Sciences of the United States of America. 98: 2381-6. PMID 11226248 DOI: 10.1073/Pnas.041603398 |
0.668 |
|
| 2000 |
Georgakopoulos A, Marambaud P, Friedrich VL, Shioi J, Efthimiopoulos S, Robakis NK. Presenilin-1: a component of synaptic and endothelial adherens junctions. Annals of the New York Academy of Sciences. 920: 209-14. PMID 11193152 DOI: 10.1111/J.1749-6632.2000.Tb06924.X |
0.622 |
|
| 2000 |
Blitzer RD, Wong T, Giovannini MG, Pangalos MN, Robakis NK, Landau EM. Amyloid beta peptides activate the phosphoinositide signaling pathway in oocytes expressing rat brain RNA. Brain Research. Molecular Brain Research. 76: 115-20. PMID 10719221 DOI: 10.1016/S0169-328X(99)00340-X |
0.371 |
|
| 2000 |
Robakis N, Marambaud P, Baki L, Georgakopoulos A, Shioi J, Serhan G, Cui W, Efthimiopoulos S. Presenilin-1 is a component of synaptic and endothelial adherens junctions: Implications for FAD Neurobiology of Aging. 21: 70. DOI: 10.1016/S0197-4580(00)82533-6 |
0.624 |
|
| 2000 |
Baki L, Marambaud P, Efthimiopoulos S, Wen P, Georgakopoulos T, Robakis NK. PS1 is a regulatory component of the cadherin/catenin adherens junction system Neurobiology of Aging. 21: 68. DOI: 10.1016/S0197-4580(00)82527-0 |
0.628 |
|
| 2000 |
Georgakopoulos T, Shioi J, Gordon R, Holstein GR, Martinelli G, Efthimiopoulos S, Friedrich VL, Robakis NK. Localization of presenilin at synaptic sites Neurobiology of Aging. 21: 182. DOI: 10.1016/S0197-4580(00)82160-0 |
0.618 |
|
| 2000 |
Marambaud P, Baki L, Georgakopoulos A, Shioi J, Efthimiopoulos S, Ozawa M, Robakis NK. Molecular organization of presenilin 1 in the E-cadherin/catenins cell adhesion system Neurobiology of Aging. 21: 181. DOI: 10.1016/S0197-4580(00)82151-X |
0.633 |
|
| 1999 |
Omar RA, Chyan YJ, Andorn AC, Poeggeler B, Robakis NK, Pappolla MA. Increased Expression but Reduced Activity of Antioxidant Enzymes in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. 1: 139-145. PMID 12213999 DOI: 10.3233/Jad-1999-1301 |
0.554 |
|
| 1999 |
Georgakopoulos A, Marambaud P, Efthimiopoulos S, Shioi J, Cui W, Li HC, Schütte M, Gordon R, Holstein GR, Martinelli G, Mehta P, Friedrich VL, Robakis NK. Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts. Molecular Cell. 4: 893-902. PMID 10635315 DOI: 10.1016/S1097-2765(00)80219-1 |
0.664 |
|
| 1999 |
Giannakopoulos P, Kövari E, Buée L, Shioi J, Hof PR, Robakis NK, Bouras C. Presenilin-1 expression in Pick's disease. Acta Neuropathologica. 98: 488-92. PMID 10541872 DOI: 10.1007/S004010051114 |
0.319 |
|
| 1999 |
Robakis NK, Efthimiopoulos S. Familial Alzheimer disease: changes in Abeta production may indicate a disturbance in protein transport or function caused by pleiotropic effects of FAD mutations. Neurobiology of Aging. 20: 81-3; discussion 87. PMID 10466898 DOI: 10.1016/S0197-4580(99)00011-1 |
0.597 |
|
| 1999 |
Figueiredo-Pereira ME, Efthimiopoulos S, Tezapsidis N, Buku A, Ghiso J, Mehta P, Robakis NK. Distinct secretases, a cysteine protease and a serine protease, generate the C termini of amyloid beta-proteins Abeta1-40 and Abeta1-42, respectively. Journal of Neurochemistry. 72: 1417-22. PMID 10098844 DOI: 10.1046/J.1471-4159.1999.721417.X |
0.686 |
|
| 1999 |
Hook VY, Sei C, Yasothornsrikul S, Toneff T, Kang YH, Efthimiopoulos S, Robakis NK, Van Nostrand W. The kunitz protease inhibitor form of the amyloid precursor protein (KPI/APP) inhibits the proneuropeptide processing enzyme prohormone thiol protease (PTP). Colocalization of KPI/APP and PTP in secretory vesicles. The Journal of Biological Chemistry. 274: 3165-72. PMID 9915856 DOI: 10.1074/jbc.274.5.3165 |
0.653 |
|
| 1998 |
Efthimiopoulos S, Floor E, Georgakopoulos A, Shioi J, Cui W, Yasothornsrikul S, Hook VY, Wisniewski T, Buee L, Robakis NK. Enrichment of presenilin 1 peptides in neuronal large dense-core and somatodendritic clathrin-coated vesicles. Journal of Neurochemistry. 71: 2365-72. PMID 9832134 DOI: 10.1046/J.1471-4159.1998.71062365.X |
0.66 |
|
| 1998 |
Pappolla M, Bozner P, Soto C, Shao H, Robakis NK, Zagorski M, Frangione B, Ghiso J. Inhibition of Alzheimer beta-fibrillogenesis by melatonin. The Journal of Biological Chemistry. 273: 7185-8. PMID 9516407 DOI: 10.1074/Jbc.273.13.7185 |
0.601 |
|
| 1998 |
Tezapsidis N, Li HC, Ripellino JA, Efthimiopoulos S, Vassilacopoulou D, Sambamurti K, Toneff T, Yasothornsrikul S, Hook VY, Robakis NK. Release of nontransmembrane full-length Alzheimer's amyloid precursor protein from the lumenar surface of chromaffin granule membranes. Biochemistry. 37: 1274-82. PMID 9477953 DOI: 10.1021/Bi9714159 |
0.66 |
|
| 1997 |
Wu A, Pangalos MN, Efthimiopoulos S, Shioi J, Robakis NK. Appican expression induces morphological changes in C6 glioma cells and promotes adhesion of neural cells to the extracellular matrix. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 4987-93. PMID 9185536 DOI: 10.1523/Jneurosci.17-13-04987.1997 |
0.66 |
|
| 1997 |
Pappolla MA, Sos M, Omar RA, Bick RJ, Hickson-Bick DL, Reiter RJ, Efthimiopoulos S, Robakis NK. Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 1683-90. PMID 9030627 DOI: 10.1523/Jneurosci.17-05-01683.1997 |
0.74 |
|
| 1997 |
Pappolla MA, Sos M, Omar RA, Bick RJ, Hickson-Bick DLM, Reiter RJ, Efthimiopoulos S, Robakis NK. Melatonin Prevents Death of Neuroblastoma Cells Exposed to the Alzheimer Amyloid Peptide The Journal of Neuroscience. 17: 1683-1690. DOI: 10.1523/JNEUROSCI.17-05-01683.1997 |
0.573 |
|
| 1996 |
Pangalos MN, Shioi J, Efthimiopoulos S, Wu A, Robakis NK. Characterization of appican, the chondroitin sulfate proteoglycan form of the Alzheimer amyloid precursor protein. Neurodegeneration : a Journal For Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration. 5: 445-51. PMID 9117561 DOI: 10.1006/Neur.1996.0061 |
0.69 |
|
| 1996 |
Elder GA, Tezapsidis N, Carter J, Shioi J, Bouras C, Li HC, Johnston JM, Efthimiopoulos S, Friedrich VL, Robakis NK. Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains. Journal of Neuroscience Research. 45: 308-20. PMID 8841992 DOI: 10.1002/(Sici)1097-4547(19960801)45:3<308::Aid-Jnr13>3.0.Co;2-# |
0.597 |
|
| 1996 |
Efthimiopoulos S, Punj S, Manolopoulos V, Pangalos M, Wang GP, Refolo LM, Robakis NK. Intracellular cyclic AMP inhibits constitutive and phorbol ester-stimulated secretory cleavage of amyloid precursor protein. Journal of Neurochemistry. 67: 872-5. PMID 8764618 DOI: 10.1046/J.1471-4159.1996.67020872.X |
0.628 |
|
| 1996 |
Efthimiopoulos S, Vassilacopoulou D, Ripellino JA, Tezapsidis N, Robakis NK. Cholinergic agonists stimulate secretion of soluble full-length amyloid precursor protein in neuroendocrine cells. Proceedings of the National Academy of Sciences of the United States of America. 93: 8046-50. PMID 8755600 DOI: 10.1073/Pnas.93.15.8046 |
0.628 |
|
| 1996 |
Shioi J, Pangalos MN, Wu A, Robakis NK. Structure and function of appican, the proteoglycan form of the alzheimer amyloid precursor Trends in Glycoscience and Glycotechnology. 8: 253-263. DOI: 10.4052/Tigg.8.253 |
0.362 |
|
| 1996 |
Pappolla M, Sos M, Reiter R, Sambamurti K, Omar R, Robakis N, Efthimiopoulos S. 589 Melatonin prevents oxidative damage and heat-shock protein induction in cultured cells exposed to the Alzheimer's amyloid beta protein (Aβ) Neurobiology of Aging. 17: S146-S147. DOI: 10.1016/S0197-4580(96)80591-4 |
0.749 |
|
| 1996 |
Vassilacopoulou D, Efthimiopoulos S, Koliopoulou P, Robakis N. 396 Soluble full length app in synaptosomes and biological fluids Neurobiology of Aging. 17: S99. DOI: 10.1016/S0197-4580(96)80398-8 |
0.628 |
|
| 1996 |
Shioi J, Tezapsidis N, Carter J, Elder G, Li D, Efthimiopoulos S, Friedrich V, Robakis N. 64 Identification of neuron specific expression of the S182/presenilin I protein Neurobiology of Aging. 17: S16. DOI: 10.1016/S0197-4580(96)80066-2 |
0.628 |
|
| 1995 |
Shioi J, Pangalos MN, Ripellino JA, Vassilacopoulou D, Mytilineou C, Margolis RU, Robakis NK. The Alzheimer amyloid precursor proteoglycan (appican) is present in brain and is produced by astrocytes but not by neurons in primary neural cultures. The Journal of Biological Chemistry. 270: 11839-44. PMID 7744833 DOI: 10.1074/Jbc.270.20.11839 |
0.357 |
|
| 1995 |
Pangalos MN, Efthimiopoulos S, Shioi J, Robakis NK. The chondroitin sulfate attachment site of appican is formed by splicing out exon 15 of the amyloid precursor gene. The Journal of Biological Chemistry. 270: 10388-91. PMID 7737970 DOI: 10.1074/Jbc.270.18.10388 |
0.686 |
|
| 1995 |
Vassilacopoulou D, Ripellino JA, Tezapsidis N, Hook VY, Robakis NK. Full-length and truncated Alzheimer amyloid precursors in chromaffin granules: solubilization of membrane amyloid precursor is mediated by an enzymatic mechanism. Journal of Neurochemistry. 64: 2140-6. PMID 7722498 DOI: 10.1046/J.1471-4159.1995.64052140.X |
0.387 |
|
| 1995 |
Pappolla MA, Sambamurti K, Efthimiopoulos S, Refolo L, Omar RA, Robakis NK. Heat-shock induces abnormalities in the cellular distribution of amyloid precursor protein (APP) and APP fusion proteins. Neuroscience Letters. 192: 105-8. PMID 7675314 DOI: 10.1016/0304-3940(95)11627-9 |
0.729 |
|
| 1995 |
Pangalos MN, Shioi J, Robakis NK. Expression of the chondroitin sulfate proteoglycans of amyloid precursor (appican) and amyloid precursor-like protein 2. Journal of Neurochemistry. 65: 762-9. PMID 7616233 DOI: 10.1046/J.1471-4159.1995.65020762.X |
0.398 |
|
| 1995 |
Refolo LM, Sambamurti K, Efthimiopoulos S, Pappolla MA, Robakis NK. Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization. Journal of Neuroscience Research. 40: 694-706. PMID 7602619 DOI: 10.1002/Jnr.490400515 |
0.732 |
|
| 1994 |
Efthimiopoulos S, Felsenstein KM, Sambamurti K, Robakis NK, Refolo LM. Study of the phorbol ester effect on Alzheimer amyloid precursor processing: sequence requirements and involvement of a cholera toxin sensitive protein. Journal of Neuroscience Research. 38: 81-90. PMID 8057394 DOI: 10.1002/Jnr.490380111 |
0.649 |
|
| 1994 |
Robakis NK, Pappolla MA. Oxygen-free radicals and amyloidosis in Alzheimer's disease: is there a connection? Neurobiology of Aging. 15: 457-9; discussion 47. PMID 7969722 DOI: 10.1016/0197-4580(94)90077-9 |
0.569 |
|
| 1994 |
Robakis NK, Pangalos MN. Involvement of amyloid as a central step in the development of Alzheimer's disease. Neurobiology of Aging. 15: S127-9. PMID 7700436 DOI: 10.1016/0197-4580(94)90189-9 |
0.34 |
|
| 1993 |
Shioi J, Refolo LM, Efthimiopoulos S, Robakis NK. Chondroitin sulfate proteoglycan form of cellular and cell-surface Alzheimer amyloid precursor. Neuroscience Letters. 154: 121-4. PMID 8361624 DOI: 10.1016/0304-3940(93)90186-O |
0.628 |
|
| 1993 |
Robakis NK, Vassilacopoulou D, Efthimiopoulos S, Sambamurti K, Refolo LM, Shioi J. Cellular processing and proteoglycan nature of amyloid precursor proteins. Annals of the New York Academy of Sciences. 695: 132-8. PMID 8239271 DOI: 10.1111/J.1749-6632.1993.Tb23041.X |
0.697 |
|
| 1992 |
Sambamurti K, Shioi J, Anderson JP, Pappolla MA, Robakis NK. Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells. Journal of Neuroscience Research. 33: 319-29. PMID 1453494 DOI: 10.1002/jnr.490330216 |
0.589 |
|
| 1992 |
Pappolla MA, Omar RA, Sambamurti K, Anderson JP, Robakis NK. The genesis of the senile plaque. Further evidence in support of its neuronal origin. The American Journal of Pathology. 141: 1151-9. PMID 1443049 |
0.572 |
|
| 1992 |
Vallet PG, Guntern R, Hof PR, Golaz J, Delacourte A, Robakis NK, Bouras C. A comparative study of histological and immunohistochemical methods for neurofibrillary tangles and senile plaques in Alzheimer's disease. Acta Neuropathologica. 83: 170-8. PMID 1373017 DOI: 10.1007/Bf00308476 |
0.322 |
|
| 1992 |
Pappolla MA, Omar RA, Kim KS, Robakis NK. Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease. The American Journal of Pathology. 140: 621-8. PMID 1372157 |
0.575 |
|
| 1992 |
Sambamurti K, Refolo LM, Shioi J, Pappolla MA, Robakis NK. The Alzheimer's amyloid precursor is cleaved intracellularly in the trans-Golgi network or in a post-Golgi compartment. Annals of the New York Academy of Sciences. 674: 118-28. PMID 1283818 DOI: 10.1111/j.1749-6632.1992.tb27481.x |
0.564 |
|
| 1990 |
Berkenbosch F, Refolo LM, Friedrich VL, Casper D, Blum M, Robakis NK. The Alzheimer's amyloid precursor protein is produced by type I astrocytes in primary cultures of rat neuroglia. Journal of Neuroscience Research. 25: 431-40. PMID 2109094 DOI: 10.1002/Jnr.490250321 |
0.366 |
|
| 1990 |
Brown HR, Goller NL, Rudelli RD, Merz GS, Wolfe GC, Wisniewski HM, Robakis NK. The mRNA encoding the scrapie agent protein is present in a variety of non-neuronal cells. Acta Neuropathologica. 80: 1-6. PMID 1972856 DOI: 10.1007/Bf00294214 |
0.488 |
|
| 1989 |
Jenkins EC, Devine-Gage EA, Yao XL, Houck GE, Brown WT, Robakis NK, Wisniewski KE, Silverman WP, Reisberg B, Wisniewski HM. Beta-amyloid protein probe hybridized to chromosome 9 in 3 Alzheimer disease individuals. Progress in Clinical and Biological Research. 317: 269-75. PMID 2690102 DOI: 10.1097/00002093-198802030-00134 |
0.486 |
|
| 1989 |
La Fauci G, Lahiri DK, Salton SR, Robakis NK. Characterization of the 5'-end region and the first two exons of the beta-protein precursor gene. Biochemical and Biophysical Research Communications. 159: 297-304. PMID 2538123 DOI: 10.1016/0006-291X(89)92437-6 |
0.322 |
|
| 1989 |
Anderson JP, Refolo LM, Haroutunian V, Bierer L, Perl D, Robakis NK, Davis KL. Processing and regional specificity of variant forms of the Alzheimer amyloid precursor protein Biological Psychiatry. 25. DOI: 10.1016/0006-3223(89)91721-6 |
0.357 |
|
| 1988 |
Jenkins EC, Devine-Gage EA, Robakis NK, Yao XL, Brown WT, Houck GE, Wolfe G, Ramakrishna N, Silverman WP, Wisniewski HM. Fine mapping of an Alzheimer disease-associated gene encoding beta-amyloid protein. Biochemical and Biophysical Research Communications. 151: 1-8. PMID 3279948 DOI: 10.1016/0006-291X(88)90551-7 |
0.515 |
|
| 1988 |
Wu Y, Dobkin C, Devine-Gage E, Ramakrishna N, Brown WT, Wisniewski HM, Robakis NK. A high frequency NcoI RFLP detected in the Alzheimer amyloid peptide gene. Nucleic Acids Research. 16: 1647. PMID 2894637 DOI: 10.1093/nar/16.4.1647 |
0.411 |
|
| 1988 |
Lafauci G, Lahiri D, Refolo L, Wallace W, Anderson J, Mehta P, Robakis NK. STRUCTURAL AND EXPRESSION STUDIES OF THE ALZHEIMER AMYLOID PRECURSOR Alzheimer Disease & Associated Disorders. 2: 279. DOI: 10.1097/00002093-198802030-00128 |
0.339 |
|
| 1988 |
Devine-Gage EA, Jenkins EC, Brown WT, Robakis NK, Wisniewski HM. The genetics of Familial Alzheimer's Disease Age. 11: 98-102. DOI: 10.1007/Bf02431747 |
0.489 |
|
| 1987 |
Robakis NK, Ramakrishna N, Wolfe G, Wisniewski HM. Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides. Proceedings of the National Academy of Sciences of the United States of America. 84: 4190-4. PMID 3035574 DOI: 10.1073/Pnas.84.12.4190 |
0.457 |
|
| 1987 |
Reeves RH, Robakis NK, Oster-Granite ML, Wisniewski HM, Coyle JT, Gearhart JD. Genetic linkage in the mouse of genes involved in Down syndrome and Alzheimer's disease in man. Brain Research. 388: 215-21. PMID 2960420 DOI: 10.1016/0169-328X(87)90028-3 |
0.481 |
|
| 1987 |
David F, Robakis NK, Lucotte G. A new TaqI polymorphism detected by the cDNA encoding amyloid beta protein of Alzheimer's disease. Nucleic Acids Research. 15: 9103. PMID 2891111 DOI: 10.1093/Nar/15.21.9103 |
0.359 |
|
| 1987 |
Jenkins EC, Devine-Gage EA, Yao XL, Houck GE, Brown WT, Wisniewski HM, Robakis NK. In-situ hybridisation of the beta-amyloid protein probe to chromosome 9 in patients with familial Alzheimer's disease. Lancet. 2: 1155-6. PMID 2890057 DOI: 10.1016/S0140-6736(87)91591-1 |
0.383 |
|
| 1987 |
Wu Y, Brown WT, Robakis NK, Dobkin C, Devine-Gage E, Merz P, Wisniewski HM. A PvuII RFLP detected in the human prion protein (PrP) gene. Nucleic Acids Research. 15: 3191. PMID 2882483 DOI: 10.1093/Nar/15.7.3191 |
0.444 |
|
| 1987 |
Robakis NK, Wisniewski HM, Jenkins EC, Devine-Gage EA, Houck GE, Yao XL, Ramakrishna N, Wolfe G, Silverman WP, Brown WT. Chromosome 21q21 sublocalisation of gene encoding beta-amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer disease and Down syndrome. Lancet. 1: 384-5. PMID 2880184 DOI: 10.1016/S0140-6736(87)91754-5 |
0.383 |
|
| 1986 |
Kascsak RJ, Rubenstein R, Merz PA, Carp RI, Robakis NK, Wisniewski HM, Diringer H. Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains. Journal of Virology. 59: 676-83. PMID 2426470 |
0.383 |
|
| 1986 |
Rubenstein R, Kascsak RJ, Merz PA, Papini MC, Carp RI, Robakis NK, Wisniewski HM. Detection of scrapie-associated fibril (SAF) proteins using anti-SAF antibody in non-purified tissue preparations. The Journal of General Virology. 67: 671-81. PMID 2420924 DOI: 10.1099/0022-1317-67-4-671 |
0.457 |
|
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