Nikolaos K. Robakis - Publications

Affiliations: 
Icahn School of Medicine at Mount Sinai, New York, NY, United States 

96 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Yoon Y, Voloudakis G, Doran N, Zhang E, Dimovasili C, Chen L, Shao Z, Darmanis S, Tang C, Tang J, Wang VX, Hof PR, Robakis NK, Georgakopoulos A. PS1 FAD mutants decrease ephrinB2-regulated angiogenic functions, ischemia-induced brain neovascularization and neuronal survival. Molecular Psychiatry. PMID 32541930 DOI: 10.1038/S41380-020-0812-7  0.336
2020 Zhao J, Xiao Y, Liu X, Kim S, Wu X, Barros M, Zhuang R, Hou X, Zhang Y, Robakis NK, Li YM, Dordick JS, Ubarretxena-Belandia I, Wang C. Substrate interaction inhibits γ-secretase production of amyloid-β peptides. Chemical Communications (Cambridge, England). PMID 32016207 DOI: 10.1039/C9Cc09170J  0.335
2019 Zhao J, Xiao Y, Liu X, Kim S, Wu X, Barros M, Zhuang M, Robakis NK, Li Y, Wang C. SUBSTRATE BINDING INHIBITS γ-SECRETASE CLEAVAGE OF AMYLOID PRECURSOR PROTEIN Alzheimers & Dementia. 15: 1595. DOI: 10.1016/J.Jalz.2019.09.052  0.337
2018 Warren NA, Voloudakis G, Yoon Y, Robakis NK, Georgakopoulos A. The product of the γ-secretase processing of ephrinB2 regulates VE-cadherin complexes and angiogenesis. Cellular and Molecular Life Sciences : Cmls. PMID 29428965 DOI: 10.1007/S00018-018-2762-7  0.727
2017 Huang Q, Voloudakis G, Ren Y, Yoon Y, Zhang E, Kajiwara Y, Shao Z, Xuan Z, Lebedev D, Georgakopoulos A, Robakis NK. Presenilin1/γ-secretase protects neurons from glucose deprivation-induced death by regulating miR-212 and PEA15. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28855274 DOI: 10.1096/Fj.201700447Rr  0.487
2017 Fullard JF, Giambartolomei C, Hauberg ME, Xu K, Voloudakis G, Shao Z, Bare C, Dudley JT, Mattheisen M, Robakis NK, Haroutunian V, Roussos P. Open chromatin profiling of human postmortem brain infers functional roles for non-coding schizophrenia loci. Human Molecular Genetics. PMID 28335009 DOI: 10.1093/Hmg/Ddx103  0.301
2016 Nikolakopoulou AM, Georgakopoulos A, Robakis NK. Presenilin 1 promotes trypsin-induced neuroprotection via the PAR2/ERK signaling pathway. Effects of presenilin 1 FAD mutations. Neurobiology of Aging. 42: 41-9. PMID 27143420 DOI: 10.1016/J.Neurobiolaging.2016.02.028  0.315
2015 Zhu L, Zhong M, Elder GA, Sano M, Holtzman DM, Gandy S, Cardozo C, Haroutunian V, Robakis NK, Cai D. Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. 112: 11965-70. PMID 26372964 DOI: 10.1073/Pnas.1510011112  0.335
2015 Bruban J, Voloudakis G, Huang Q, Kajiwara Y, Al Rahim M, Yoon Y, Shioi J, Gama Sosa MA, Shao Z, Georgakopoulos A, Robakis NK. Presenilin 1 is necessary for neuronal, but not glial, EGFR expression and neuroprotection via γ-secretase-independent transcriptional mechanisms. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 25985800 DOI: 10.1096/Fj.15-270645  0.304
2014 Robakis NK, Georgakopoulos A. Allelic interference: a mechanism for trans-dominant transmission of loss of function in the neurodegeneration of familial Alzheimer's disease. Neuro-Degenerative Diseases. 13: 126-30. PMID 24081144 DOI: 10.1159/000354241  0.393
2013 Zhu L, Zhong M, Zhao J, Rhee H, Caesar I, Knight EM, Volpicelli-Daley L, Bustos V, Netzer W, Liu L, Lucast L, Ehrlich ME, Robakis NK, Gandy SE, Cai D. Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model. The Journal of Biological Chemistry. 288: 32050-63. PMID 24052255 DOI: 10.1074/Jbc.M113.504365  0.384
2013 Xuan Z, Barthet G, Shioi J, Xu J, Georgakopoulos A, Bruban J, Robakis NK. Presenilin-1/γ-secretase controls glutamate release, tyrosine phosphorylation, and surface expression of N-methyl-D-aspartate receptor (NMDAR) subunit GluN2B. The Journal of Biological Chemistry. 288: 30495-501. PMID 24025330 DOI: 10.1074/Jbc.M113.499004  0.561
2013 Barthet G, Dunys J, Shao Z, Xuan Z, Ren Y, Xu J, Arbez N, Mauger G, Bruban J, Georgakopoulos A, Shioi J, Robakis NK. Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors. Neurobiology of Aging. 34: 499-510. PMID 22475621 DOI: 10.1016/J.Neurobiolaging.2012.02.024  0.568
2012 Barthet G, Georgakopoulos A, Robakis NK. Cellular mechanisms of γ-secretase substrate selection, processing and toxicity. Progress in Neurobiology. 98: 166-75. PMID 22622135 DOI: 10.1016/J.Pneurobio.2012.05.006  0.355
2011 Georgakopoulos A, Xu J, Xu C, Mauger G, Barthet G, Robakis NK. Presenilin1/gamma-secretase promotes the EphB2-induced phosphorylation of ephrinB2 by regulating phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk binding protein. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 3594-604. PMID 21746865 DOI: 10.1096/Fj.11-187856  0.367
2010 Pimplikar SW, Nixon RA, Robakis NK, Shen J, Tsai LH. Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 14946-54. PMID 21068297 DOI: 10.1523/Jneurosci.4305-10.2010  0.359
2009 Xu J, Litterst C, Georgakopoulos A, Zaganas I, Robakis NK. Peptide EphB2/CTF2 generated by the gamma-secretase processing of EphB2 receptor promotes tyrosine phosphorylation and cell surface localization of N-methyl-D-aspartate receptors. The Journal of Biological Chemistry. 284: 27220-8. PMID 19661068 DOI: 10.1074/Jbc.M109.048728  0.334
2009 Tezapsidis N, Johnston JM, Smith MA, Ashford JW, Casadesus G, Robakis NK, Wolozin B, Perry G, Zhu X, Greco SJ, Sarkar S. Leptin: a novel therapeutic strategy for Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 16: 731-40. PMID 19387109 DOI: 10.3233/Jad-2009-1021  0.47
2009 Kouchi Z, Barthet G, Serban G, Georgakopoulos A, Shioi J, Robakis NK. p120 catenin recruits cadherins to gamma-secretase and inhibits production of Abeta peptide. The Journal of Biological Chemistry. 284: 1954-61. PMID 19008223 DOI: 10.1074/Jbc.M806250200  0.639
2008 Baki L, Neve RL, Shao Z, Shioi J, Georgakopoulos A, Robakis NK. Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase neuroprotective signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 483-90. PMID 18184791 DOI: 10.1523/Jneurosci.4067-07.2008  0.307
2008 Baki L, Neve RL, Shao Z, Shioi J, Georgakopoulos A, Robakis NK. P4-195: Presenilin1 prevents neurodegeneration by stimulating PI3K/Akt neuroprotective signaling: Effects of PS1 familial Alzheimer's disease mutations Alzheimer's & Dementia. 4: T728-T728. DOI: 10.1016/J.Jalz.2008.05.2262  0.307
2007 Fassa A, Parisiadou L, Robakis NK, Efthimiopoulos S. Novel processing of Notch 1 within its intracellular domain by a cysteine protease. Neuro-Degenerative Diseases. 4: 148-55. PMID 17596709 DOI: 10.1159/000101839  0.751
2007 Litterst C, Georgakopoulos A, Shioi J, Ghersi E, Wisniewski T, Wang R, Ludwig A, Robakis NK. Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor. The Journal of Biological Chemistry. 282: 16155-63. PMID 17428795 DOI: 10.1074/Jbc.M611449200  0.317
2007 Shioi J, Georgakopoulos A, Mehta P, Kouchi Z, Litterst CM, Baki L, Robakis NK. FAD mutants unable to increase neurotoxic Abeta 42 suggest that mutation effects on neurodegeneration may be independent of effects on Abeta. Journal of Neurochemistry. 101: 674-81. PMID 17254019 DOI: 10.1111/J.1471-4159.2006.04391.X  0.366
2006 Arnaud L, Robakis NK, Figueiredo-Pereira ME. It may take inflammation, phosphorylation and ubiquitination to 'tangle' in Alzheimer's disease. Neuro-Degenerative Diseases. 3: 313-9. PMID 16954650 DOI: 10.1159/000095638  0.352
2006 Georgakopoulos A, Litterst C, Ghersi E, Baki L, Xu C, Serban G, Robakis NK. Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling. The Embo Journal. 25: 1242-52. PMID 16511561 DOI: 10.1038/Sj.Emboj.7601031  0.601
2006 Georgakopoulos A, Litterst C, Ghersi E, Baki L, Xu C, Serban G, Robakis NK. O3-03-02: PS1/γ-secretase regulate the EphB-induced Src signaling Alzheimer's & Dementia. 2: S56-S57. DOI: 10.1016/J.Jalz.2006.05.206  0.567
2006 Shioi J, Dolcini V, Baki L, Mehta P, Georgakopoulos T, Robakis NK. P3-220: Test of PI3K/Akt signaling hypothesis for mechanism of AD using unique PS1 FAD mutations that do not affect Aβ42 production Alzheimer's & Dementia. 2: S440-S440. DOI: 10.1016/J.Jalz.2006.05.1489  0.312
2005 Serban G, Kouchi Z, Baki L, Georgakopoulos A, Litterst CM, Shioi J, Robakis NK. Cadherins mediate both the association between PS1 and beta-catenin and the effects of PS1 on beta-catenin stability. The Journal of Biological Chemistry. 280: 36007-12. PMID 16126725 DOI: 10.1074/Jbc.M507503200  0.618
2004 Wen PH, Hof PR, Chen X, Gluck K, Austin G, Younkin SG, Younkin LH, DeGasperi R, Gama Sosa MA, Robakis NK, Haroutunian V, Elder GA. The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice. Experimental Neurology. 188: 224-37. PMID 15246822 DOI: 10.1016/J.Expneurol.2004.04.002  0.307
2004 Serban G, Marambaud P, Litterst C, Robakis N. P3-330 γ-secretase processing of VE-cadherin regulates CBP-mediated transcription Neurobiology of Aging. 25: S449. DOI: 10.1016/S0197-4580(04)81480-5  0.574
2004 Marambaud P, Wen PH, Dutt A, Shioi J, Serban G, Takashima A, Siman R, Robakis NK. O3-05-02 FAD-linked presenilin-1 mutations affect the N-cadherin/CBP signaling pathway via a loss-of-function mechanism Neurobiology of Aging. 25: S61-S62. DOI: 10.1016/S0197-4580(04)80207-0  0.567
2003 Qin W, Ho L, Pompl PN, Peng Y, Zhao Z, Xiang Z, Robakis NK, Shioi J, Suh J, Pasinetti GM. Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity. The Journal of Biological Chemistry. 278: 50970-7. PMID 14507922 DOI: 10.1074/Jbc.M307699200  0.376
2002 Wen PH, Shao X, Shao Z, Hof PR, Wisniewski T, Kelley K, Friedrich VL, Ho L, Pasinetti GM, Shioi J, Robakis NK, Elder GA. Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice. Neurobiology of Disease. 10: 8-19. PMID 12079399 DOI: 10.1006/Nbdi.2002.0490  0.308
2002 Bussière T, Friend PD, Sadeghi N, Wicinski B, Lin GI, Bouras C, Giannakopoulos P, Robakis NK, Morrison JH, Perl DP, Hof PR. Stereologic assessment of the total cortical volume occupied by amyloid deposits and its relationship with cognitive status in aging and Alzheimer's disease. Neuroscience. 112: 75-91. PMID 12044473 DOI: 10.1016/S0306-4522(02)00056-8  0.314
2002 Marambaud P, Shioi J, Serban G, Georgakopoulos A, Sarner S, Nagy V, Baki L, Wen P, Efthimiopoulos S, Shao Z, Wisniewski T, Robakis NK. A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. The Embo Journal. 21: 1948-56. PMID 11953314 DOI: 10.1093/Emboj/21.8.1948  0.742
2001 Baki L, Marambaud P, Efthimiopoulos S, Georgakopoulos A, Wen P, Cui W, Shioi J, Koo E, Ozawa M, Friedrich VL, Robakis NK. Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex. Proceedings of the National Academy of Sciences of the United States of America. 98: 2381-6. PMID 11226248 DOI: 10.1073/Pnas.041603398  0.668
2000 Georgakopoulos A, Marambaud P, Friedrich VL, Shioi J, Efthimiopoulos S, Robakis NK. Presenilin-1: a component of synaptic and endothelial adherens junctions. Annals of the New York Academy of Sciences. 920: 209-14. PMID 11193152 DOI: 10.1111/J.1749-6632.2000.Tb06924.X  0.622
2000 Blitzer RD, Wong T, Giovannini MG, Pangalos MN, Robakis NK, Landau EM. Amyloid beta peptides activate the phosphoinositide signaling pathway in oocytes expressing rat brain RNA. Brain Research. Molecular Brain Research. 76: 115-20. PMID 10719221 DOI: 10.1016/S0169-328X(99)00340-X  0.371
2000 Robakis N, Marambaud P, Baki L, Georgakopoulos A, Shioi J, Serhan G, Cui W, Efthimiopoulos S. Presenilin-1 is a component of synaptic and endothelial adherens junctions: Implications for FAD Neurobiology of Aging. 21: 70. DOI: 10.1016/S0197-4580(00)82533-6  0.624
2000 Baki L, Marambaud P, Efthimiopoulos S, Wen P, Georgakopoulos T, Robakis NK. PS1 is a regulatory component of the cadherin/catenin adherens junction system Neurobiology of Aging. 21: 68. DOI: 10.1016/S0197-4580(00)82527-0  0.628
2000 Georgakopoulos T, Shioi J, Gordon R, Holstein GR, Martinelli G, Efthimiopoulos S, Friedrich VL, Robakis NK. Localization of presenilin at synaptic sites Neurobiology of Aging. 21: 182. DOI: 10.1016/S0197-4580(00)82160-0  0.618
2000 Marambaud P, Baki L, Georgakopoulos A, Shioi J, Efthimiopoulos S, Ozawa M, Robakis NK. Molecular organization of presenilin 1 in the E-cadherin/catenins cell adhesion system Neurobiology of Aging. 21: 181. DOI: 10.1016/S0197-4580(00)82151-X  0.633
1999 Omar RA, Chyan YJ, Andorn AC, Poeggeler B, Robakis NK, Pappolla MA. Increased Expression but Reduced Activity of Antioxidant Enzymes in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. 1: 139-145. PMID 12213999 DOI: 10.3233/Jad-1999-1301  0.554
1999 Georgakopoulos A, Marambaud P, Efthimiopoulos S, Shioi J, Cui W, Li HC, Schütte M, Gordon R, Holstein GR, Martinelli G, Mehta P, Friedrich VL, Robakis NK. Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts. Molecular Cell. 4: 893-902. PMID 10635315 DOI: 10.1016/S1097-2765(00)80219-1  0.664
1999 Giannakopoulos P, Kövari E, Buée L, Shioi J, Hof PR, Robakis NK, Bouras C. Presenilin-1 expression in Pick's disease. Acta Neuropathologica. 98: 488-92. PMID 10541872 DOI: 10.1007/S004010051114  0.319
1999 Robakis NK, Efthimiopoulos S. Familial Alzheimer disease: changes in Abeta production may indicate a disturbance in protein transport or function caused by pleiotropic effects of FAD mutations. Neurobiology of Aging. 20: 81-3; discussion 87. PMID 10466898 DOI: 10.1016/S0197-4580(99)00011-1  0.597
1999 Figueiredo-Pereira ME, Efthimiopoulos S, Tezapsidis N, Buku A, Ghiso J, Mehta P, Robakis NK. Distinct secretases, a cysteine protease and a serine protease, generate the C termini of amyloid beta-proteins Abeta1-40 and Abeta1-42, respectively. Journal of Neurochemistry. 72: 1417-22. PMID 10098844 DOI: 10.1046/J.1471-4159.1999.721417.X  0.686
1999 Hook VY, Sei C, Yasothornsrikul S, Toneff T, Kang YH, Efthimiopoulos S, Robakis NK, Van Nostrand W. The kunitz protease inhibitor form of the amyloid precursor protein (KPI/APP) inhibits the proneuropeptide processing enzyme prohormone thiol protease (PTP). Colocalization of KPI/APP and PTP in secretory vesicles. The Journal of Biological Chemistry. 274: 3165-72. PMID 9915856 DOI: 10.1074/jbc.274.5.3165  0.653
1998 Efthimiopoulos S, Floor E, Georgakopoulos A, Shioi J, Cui W, Yasothornsrikul S, Hook VY, Wisniewski T, Buee L, Robakis NK. Enrichment of presenilin 1 peptides in neuronal large dense-core and somatodendritic clathrin-coated vesicles. Journal of Neurochemistry. 71: 2365-72. PMID 9832134 DOI: 10.1046/J.1471-4159.1998.71062365.X  0.66
1998 Pappolla M, Bozner P, Soto C, Shao H, Robakis NK, Zagorski M, Frangione B, Ghiso J. Inhibition of Alzheimer beta-fibrillogenesis by melatonin. The Journal of Biological Chemistry. 273: 7185-8. PMID 9516407 DOI: 10.1074/Jbc.273.13.7185  0.601
1998 Tezapsidis N, Li HC, Ripellino JA, Efthimiopoulos S, Vassilacopoulou D, Sambamurti K, Toneff T, Yasothornsrikul S, Hook VY, Robakis NK. Release of nontransmembrane full-length Alzheimer's amyloid precursor protein from the lumenar surface of chromaffin granule membranes. Biochemistry. 37: 1274-82. PMID 9477953 DOI: 10.1021/Bi9714159  0.66
1997 Wu A, Pangalos MN, Efthimiopoulos S, Shioi J, Robakis NK. Appican expression induces morphological changes in C6 glioma cells and promotes adhesion of neural cells to the extracellular matrix. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 4987-93. PMID 9185536 DOI: 10.1523/Jneurosci.17-13-04987.1997  0.66
1997 Pappolla MA, Sos M, Omar RA, Bick RJ, Hickson-Bick DL, Reiter RJ, Efthimiopoulos S, Robakis NK. Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 1683-90. PMID 9030627 DOI: 10.1523/Jneurosci.17-05-01683.1997  0.74
1997 Pappolla MA, Sos M, Omar RA, Bick RJ, Hickson-Bick DLM, Reiter RJ, Efthimiopoulos S, Robakis NK. Melatonin Prevents Death of Neuroblastoma Cells Exposed to the Alzheimer Amyloid Peptide The Journal of Neuroscience. 17: 1683-1690. DOI: 10.1523/JNEUROSCI.17-05-01683.1997  0.573
1996 Pangalos MN, Shioi J, Efthimiopoulos S, Wu A, Robakis NK. Characterization of appican, the chondroitin sulfate proteoglycan form of the Alzheimer amyloid precursor protein. Neurodegeneration : a Journal For Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration. 5: 445-51. PMID 9117561 DOI: 10.1006/Neur.1996.0061  0.69
1996 Elder GA, Tezapsidis N, Carter J, Shioi J, Bouras C, Li HC, Johnston JM, Efthimiopoulos S, Friedrich VL, Robakis NK. Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains. Journal of Neuroscience Research. 45: 308-20. PMID 8841992 DOI: 10.1002/(Sici)1097-4547(19960801)45:3<308::Aid-Jnr13>3.0.Co;2-#  0.597
1996 Efthimiopoulos S, Punj S, Manolopoulos V, Pangalos M, Wang GP, Refolo LM, Robakis NK. Intracellular cyclic AMP inhibits constitutive and phorbol ester-stimulated secretory cleavage of amyloid precursor protein. Journal of Neurochemistry. 67: 872-5. PMID 8764618 DOI: 10.1046/J.1471-4159.1996.67020872.X  0.628
1996 Efthimiopoulos S, Vassilacopoulou D, Ripellino JA, Tezapsidis N, Robakis NK. Cholinergic agonists stimulate secretion of soluble full-length amyloid precursor protein in neuroendocrine cells. Proceedings of the National Academy of Sciences of the United States of America. 93: 8046-50. PMID 8755600 DOI: 10.1073/Pnas.93.15.8046  0.628
1996 Shioi J, Pangalos MN, Wu A, Robakis NK. Structure and function of appican, the proteoglycan form of the alzheimer amyloid precursor Trends in Glycoscience and Glycotechnology. 8: 253-263. DOI: 10.4052/Tigg.8.253  0.362
1996 Pappolla M, Sos M, Reiter R, Sambamurti K, Omar R, Robakis N, Efthimiopoulos S. 589 Melatonin prevents oxidative damage and heat-shock protein induction in cultured cells exposed to the Alzheimer's amyloid beta protein (Aβ) Neurobiology of Aging. 17: S146-S147. DOI: 10.1016/S0197-4580(96)80591-4  0.749
1996 Vassilacopoulou D, Efthimiopoulos S, Koliopoulou P, Robakis N. 396 Soluble full length app in synaptosomes and biological fluids Neurobiology of Aging. 17: S99. DOI: 10.1016/S0197-4580(96)80398-8  0.628
1996 Shioi J, Tezapsidis N, Carter J, Elder G, Li D, Efthimiopoulos S, Friedrich V, Robakis N. 64 Identification of neuron specific expression of the S182/presenilin I protein Neurobiology of Aging. 17: S16. DOI: 10.1016/S0197-4580(96)80066-2  0.628
1995 Shioi J, Pangalos MN, Ripellino JA, Vassilacopoulou D, Mytilineou C, Margolis RU, Robakis NK. The Alzheimer amyloid precursor proteoglycan (appican) is present in brain and is produced by astrocytes but not by neurons in primary neural cultures. The Journal of Biological Chemistry. 270: 11839-44. PMID 7744833 DOI: 10.1074/Jbc.270.20.11839  0.357
1995 Pangalos MN, Efthimiopoulos S, Shioi J, Robakis NK. The chondroitin sulfate attachment site of appican is formed by splicing out exon 15 of the amyloid precursor gene. The Journal of Biological Chemistry. 270: 10388-91. PMID 7737970 DOI: 10.1074/Jbc.270.18.10388  0.686
1995 Vassilacopoulou D, Ripellino JA, Tezapsidis N, Hook VY, Robakis NK. Full-length and truncated Alzheimer amyloid precursors in chromaffin granules: solubilization of membrane amyloid precursor is mediated by an enzymatic mechanism. Journal of Neurochemistry. 64: 2140-6. PMID 7722498 DOI: 10.1046/J.1471-4159.1995.64052140.X  0.387
1995 Pappolla MA, Sambamurti K, Efthimiopoulos S, Refolo L, Omar RA, Robakis NK. Heat-shock induces abnormalities in the cellular distribution of amyloid precursor protein (APP) and APP fusion proteins. Neuroscience Letters. 192: 105-8. PMID 7675314 DOI: 10.1016/0304-3940(95)11627-9  0.729
1995 Pangalos MN, Shioi J, Robakis NK. Expression of the chondroitin sulfate proteoglycans of amyloid precursor (appican) and amyloid precursor-like protein 2. Journal of Neurochemistry. 65: 762-9. PMID 7616233 DOI: 10.1046/J.1471-4159.1995.65020762.X  0.398
1995 Refolo LM, Sambamurti K, Efthimiopoulos S, Pappolla MA, Robakis NK. Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization. Journal of Neuroscience Research. 40: 694-706. PMID 7602619 DOI: 10.1002/Jnr.490400515  0.732
1994 Efthimiopoulos S, Felsenstein KM, Sambamurti K, Robakis NK, Refolo LM. Study of the phorbol ester effect on Alzheimer amyloid precursor processing: sequence requirements and involvement of a cholera toxin sensitive protein. Journal of Neuroscience Research. 38: 81-90. PMID 8057394 DOI: 10.1002/Jnr.490380111  0.649
1994 Robakis NK, Pappolla MA. Oxygen-free radicals and amyloidosis in Alzheimer's disease: is there a connection? Neurobiology of Aging. 15: 457-9; discussion 47. PMID 7969722 DOI: 10.1016/0197-4580(94)90077-9  0.569
1994 Robakis NK, Pangalos MN. Involvement of amyloid as a central step in the development of Alzheimer's disease. Neurobiology of Aging. 15: S127-9. PMID 7700436 DOI: 10.1016/0197-4580(94)90189-9  0.34
1993 Shioi J, Refolo LM, Efthimiopoulos S, Robakis NK. Chondroitin sulfate proteoglycan form of cellular and cell-surface Alzheimer amyloid precursor. Neuroscience Letters. 154: 121-4. PMID 8361624 DOI: 10.1016/0304-3940(93)90186-O  0.628
1993 Robakis NK, Vassilacopoulou D, Efthimiopoulos S, Sambamurti K, Refolo LM, Shioi J. Cellular processing and proteoglycan nature of amyloid precursor proteins. Annals of the New York Academy of Sciences. 695: 132-8. PMID 8239271 DOI: 10.1111/J.1749-6632.1993.Tb23041.X  0.697
1992 Sambamurti K, Shioi J, Anderson JP, Pappolla MA, Robakis NK. Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells. Journal of Neuroscience Research. 33: 319-29. PMID 1453494 DOI: 10.1002/jnr.490330216  0.589
1992 Pappolla MA, Omar RA, Sambamurti K, Anderson JP, Robakis NK. The genesis of the senile plaque. Further evidence in support of its neuronal origin. The American Journal of Pathology. 141: 1151-9. PMID 1443049  0.572
1992 Vallet PG, Guntern R, Hof PR, Golaz J, Delacourte A, Robakis NK, Bouras C. A comparative study of histological and immunohistochemical methods for neurofibrillary tangles and senile plaques in Alzheimer's disease. Acta Neuropathologica. 83: 170-8. PMID 1373017 DOI: 10.1007/Bf00308476  0.322
1992 Pappolla MA, Omar RA, Kim KS, Robakis NK. Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease. The American Journal of Pathology. 140: 621-8. PMID 1372157  0.575
1992 Sambamurti K, Refolo LM, Shioi J, Pappolla MA, Robakis NK. The Alzheimer's amyloid precursor is cleaved intracellularly in the trans-Golgi network or in a post-Golgi compartment. Annals of the New York Academy of Sciences. 674: 118-28. PMID 1283818 DOI: 10.1111/j.1749-6632.1992.tb27481.x  0.564
1990 Berkenbosch F, Refolo LM, Friedrich VL, Casper D, Blum M, Robakis NK. The Alzheimer's amyloid precursor protein is produced by type I astrocytes in primary cultures of rat neuroglia. Journal of Neuroscience Research. 25: 431-40. PMID 2109094 DOI: 10.1002/Jnr.490250321  0.366
1990 Brown HR, Goller NL, Rudelli RD, Merz GS, Wolfe GC, Wisniewski HM, Robakis NK. The mRNA encoding the scrapie agent protein is present in a variety of non-neuronal cells. Acta Neuropathologica. 80: 1-6. PMID 1972856 DOI: 10.1007/Bf00294214  0.488
1989 Jenkins EC, Devine-Gage EA, Yao XL, Houck GE, Brown WT, Robakis NK, Wisniewski KE, Silverman WP, Reisberg B, Wisniewski HM. Beta-amyloid protein probe hybridized to chromosome 9 in 3 Alzheimer disease individuals. Progress in Clinical and Biological Research. 317: 269-75. PMID 2690102 DOI: 10.1097/00002093-198802030-00134  0.486
1989 La Fauci G, Lahiri DK, Salton SR, Robakis NK. Characterization of the 5'-end region and the first two exons of the beta-protein precursor gene. Biochemical and Biophysical Research Communications. 159: 297-304. PMID 2538123 DOI: 10.1016/0006-291X(89)92437-6  0.322
1989 Anderson JP, Refolo LM, Haroutunian V, Bierer L, Perl D, Robakis NK, Davis KL. Processing and regional specificity of variant forms of the Alzheimer amyloid precursor protein Biological Psychiatry. 25. DOI: 10.1016/0006-3223(89)91721-6  0.357
1988 Jenkins EC, Devine-Gage EA, Robakis NK, Yao XL, Brown WT, Houck GE, Wolfe G, Ramakrishna N, Silverman WP, Wisniewski HM. Fine mapping of an Alzheimer disease-associated gene encoding beta-amyloid protein. Biochemical and Biophysical Research Communications. 151: 1-8. PMID 3279948 DOI: 10.1016/0006-291X(88)90551-7  0.515
1988 Wu Y, Dobkin C, Devine-Gage E, Ramakrishna N, Brown WT, Wisniewski HM, Robakis NK. A high frequency NcoI RFLP detected in the Alzheimer amyloid peptide gene. Nucleic Acids Research. 16: 1647. PMID 2894637 DOI: 10.1093/nar/16.4.1647  0.411
1988 Lafauci G, Lahiri D, Refolo L, Wallace W, Anderson J, Mehta P, Robakis NK. STRUCTURAL AND EXPRESSION STUDIES OF THE ALZHEIMER AMYLOID PRECURSOR Alzheimer Disease & Associated Disorders. 2: 279. DOI: 10.1097/00002093-198802030-00128  0.339
1988 Devine-Gage EA, Jenkins EC, Brown WT, Robakis NK, Wisniewski HM. The genetics of Familial Alzheimer's Disease Age. 11: 98-102. DOI: 10.1007/Bf02431747  0.489
1987 Robakis NK, Ramakrishna N, Wolfe G, Wisniewski HM. Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides. Proceedings of the National Academy of Sciences of the United States of America. 84: 4190-4. PMID 3035574 DOI: 10.1073/Pnas.84.12.4190  0.457
1987 Reeves RH, Robakis NK, Oster-Granite ML, Wisniewski HM, Coyle JT, Gearhart JD. Genetic linkage in the mouse of genes involved in Down syndrome and Alzheimer's disease in man. Brain Research. 388: 215-21. PMID 2960420 DOI: 10.1016/0169-328X(87)90028-3  0.481
1987 David F, Robakis NK, Lucotte G. A new TaqI polymorphism detected by the cDNA encoding amyloid beta protein of Alzheimer's disease. Nucleic Acids Research. 15: 9103. PMID 2891111 DOI: 10.1093/Nar/15.21.9103  0.359
1987 Jenkins EC, Devine-Gage EA, Yao XL, Houck GE, Brown WT, Wisniewski HM, Robakis NK. In-situ hybridisation of the beta-amyloid protein probe to chromosome 9 in patients with familial Alzheimer's disease. Lancet. 2: 1155-6. PMID 2890057 DOI: 10.1016/S0140-6736(87)91591-1  0.383
1987 Wu Y, Brown WT, Robakis NK, Dobkin C, Devine-Gage E, Merz P, Wisniewski HM. A PvuII RFLP detected in the human prion protein (PrP) gene. Nucleic Acids Research. 15: 3191. PMID 2882483 DOI: 10.1093/Nar/15.7.3191  0.444
1987 Robakis NK, Wisniewski HM, Jenkins EC, Devine-Gage EA, Houck GE, Yao XL, Ramakrishna N, Wolfe G, Silverman WP, Brown WT. Chromosome 21q21 sublocalisation of gene encoding beta-amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer disease and Down syndrome. Lancet. 1: 384-5. PMID 2880184 DOI: 10.1016/S0140-6736(87)91754-5  0.383
1986 Kascsak RJ, Rubenstein R, Merz PA, Carp RI, Robakis NK, Wisniewski HM, Diringer H. Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains. Journal of Virology. 59: 676-83. PMID 2426470  0.383
1986 Rubenstein R, Kascsak RJ, Merz PA, Papini MC, Carp RI, Robakis NK, Wisniewski HM. Detection of scrapie-associated fibril (SAF) proteins using anti-SAF antibody in non-purified tissue preparations. The Journal of General Virology. 67: 671-81. PMID 2420924 DOI: 10.1099/0022-1317-67-4-671  0.457
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