Nikolaos K. Robakis - Publications

Affiliations: 
Icahn School of Medicine at Mount Sinai, New York, NY, United States 

141 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Al Rahim M, Yoon Y, Dimovasili C, Shao Z, Huang Q, Zhang E, Kezunovic N, Chen L, Schaffner A, Huntley GW, Ubarretxena-Belandia I, Georgakopoulos A, Robakis NK. Presenilin1 familial Alzheimer disease mutants inactivate EFNB1- and BDNF-dependent neuroprotection against excitotoxicity by affecting neuroprotective complexes of -methyl-d-aspartate receptor. Brain Communications. 2: fcaa100. PMID 33005890 DOI: 10.1093/braincomms/fcaa100  0.32
2020 Yoon Y, Voloudakis G, Doran N, Zhang E, Dimovasili C, Chen L, Shao Z, Darmanis S, Tang C, Tang J, Wang VX, Hof PR, Robakis NK, Georgakopoulos A. PS1 FAD mutants decrease ephrinB2-regulated angiogenic functions, ischemia-induced brain neovascularization and neuronal survival. Molecular Psychiatry. PMID 32541930 DOI: 10.1038/s41380-020-0812-7  0.32
2018 Fullard JF, Giambartolomei C, Hauberg ME, Xu K, Voloudakis G, Shao Z, Bare C, Dudley JT, Mattheisen M, Robakis NK, Haroutunian V, Roussos P. Open chromatin profiling of human postmortem brain infers functional roles for non-coding schizophrenia loci. Human Molecular Genetics. PMID 29982455 DOI: 10.1093/hmg/ddy229  0.32
2018 Warren NA, Voloudakis G, Yoon Y, Robakis NK, Georgakopoulos A. The product of the γ-secretase processing of ephrinB2 regulates VE-cadherin complexes and angiogenesis. Cellular and Molecular Life Sciences : Cmls. PMID 29428965 DOI: 10.1007/s00018-018-2762-7  0.32
2017 Huang Q, Voloudakis G, Ren Y, Yoon Y, Zhang E, Kajiwara Y, Shao Z, Xuan Z, Lebedev D, Georgakopoulos A, Robakis NK. Presenilin1/γ-secretase protects neurons from glucose deprivation-induced death by regulating miR-212 and PEA15. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28855274 DOI: 10.1096/fj.201700447RR  0.32
2017 Fullard JF, Giambartolomei C, Hauberg ME, Xu K, Voloudakis G, Shao Z, Bare C, Dudley JT, Mattheisen M, Robakis NK, Haroutunian V, Roussos P. Open chromatin profiling of human postmortem brain infers functional roles for non-coding schizophrenia loci. Human Molecular Genetics. PMID 28335009 DOI: 10.1093/hmg/ddx103  0.32
2016 Nikolakopoulou AM, Georgakopoulos A, Robakis NK. Presenilin 1 promotes trypsin-induced neuroprotection via the PAR2/ERK signaling pathway. Effects of presenilin 1 FAD mutations. Neurobiology of Aging. 42: 41-9. PMID 27143420 DOI: 10.1016/j.neurobiolaging.2016.02.028  1
2016 Moreno JL, Miranda-Azpiazu P, García-Bea A, Younkin J, Cui M, Kozlenkov A, Ben-Ezra A, Voloudakis G, Fakira AK, Baki L, Ge Y, Georgakopoulos A, Morón JA, Milligan G, López-Giménez JF, ... Robakis NK, et al. Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia. Science Signaling. 9: ra5. PMID 26758213 DOI: 10.1126/scisignal.aab0467  1
2015 Zhu L, Zhong M, Elder GA, Sano M, Holtzman DM, Gandy S, Cardozo C, Haroutunian V, Robakis NK, Cai D. Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. 112: 11965-70. PMID 26372964 DOI: 10.1073/pnas.1510011112  1
2015 Bruban J, Voloudakis G, Huang Q, Kajiwara Y, Al Rahim M, Yoon Y, Shioi J, Gama Sosa MA, Shao Z, Georgakopoulos A, Robakis NK. Presenilin 1 is necessary for neuronal, but not glial, EGFR expression and neuroprotection via γ-secretase-independent transcriptional mechanisms. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 25985800 DOI: 10.1096/fj.15-270645  1
2015 Robakis NK. Molecular neuropathology of Alzheimer dementia and therapeutic approaches. Advances in Experimental Medicine and Biology. 822: 1. PMID 25416969 DOI: 10.1007/978-3-319-08927-0_1  1
2014 Roussos P, Mitchell AC, Voloudakis G, Fullard JF, Pothula VM, Tsang J, Stahl EA, Georgakopoulos A, Ruderfer DM, Charney A, Okada Y, Siminovitch KA, Worthington J, Padyukov L, Klareskog L, ... ... Robakis NK, et al. A role for noncoding variation in schizophrenia. Cell Reports. 9: 1417-29. PMID 25453756 DOI: 10.1016/j.celrep.2014.10.015  1
2014 Robakis NK, Georgakopoulos A. Allelic interference: a mechanism for trans-dominant transmission of loss of function in the neurodegeneration of familial Alzheimer's disease. Neuro-Degenerative Diseases. 13: 126-30. PMID 24081144 DOI: 10.1159/000354241  1
2014 Robakis NK. Cell signaling abnormalities may drive neurodegeneration in familial Alzheimer disease. Neurochemical Research. 39: 570-5. PMID 23436150 DOI: 10.1007/s11064-013-1003-6  1
2013 Alonso Adel C, ElAkkad E, Gong C, Liu F, Tanaka T, Kudo T, Tatebayashi Y, Pei J, Wang J, Khatoon S, Flory M, Ghetti B, Gozes I, Novak M, Novak M, ... Robakis NK, et al. Inge Grundke-Iqbal, Ph.D. (1937–2012): the discoverer of the abnormal hyperphosphorylation of tau in Alzheimer’s disease. Journal of Molecular Neuroscience : Mn. 49: 430-5. PMID 24883456 DOI: 10.1007/s12031-012-9925-z  1
2013 Zhu L, Zhong M, Zhao J, Rhee H, Caesar I, Knight EM, Volpicelli-Daley L, Bustos V, Netzer W, Liu L, Lucast L, Ehrlich ME, Robakis NK, Gandy SE, Cai D. Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model. The Journal of Biological Chemistry. 288: 32050-63. PMID 24052255 DOI: 10.1074/jbc.M113.504365  1
2013 Xuan Z, Barthet G, Shioi J, Xu J, Georgakopoulos A, Bruban J, Robakis NK. Presenilin-1/γ-secretase controls glutamate release, tyrosine phosphorylation, and surface expression of N-methyl-D-aspartate receptor (NMDAR) subunit GluN2B. The Journal of Biological Chemistry. 288: 30495-501. PMID 24025330 DOI: 10.1074/jbc.M113.499004  1
2013 Barthet G, Dunys J, Shao Z, Xuan Z, Ren Y, Xu J, Arbez N, Mauger G, Bruban J, Georgakopoulos A, Shioi J, Robakis NK. Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors. Neurobiology of Aging. 34: 499-510. PMID 22475621 DOI: 10.1016/j.neurobiolaging.2012.02.024  1
2012 Barthet G, Georgakopoulos A, Robakis NK. Cellular mechanisms of γ-secretase substrate selection, processing and toxicity. Progress in Neurobiology. 98: 166-75. PMID 22622135 DOI: 10.1016/j.pneurobio.2012.05.006  1
2011 Xu J, Xilouri M, Bruban J, Shioi J, Shao Z, Papazoglou I, Vekrellis K, Robakis NK. Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling. Neurobiology of Aging. 32: 2326.e5-16. PMID 21820214 DOI: 10.1016/j.neurobiolaging.2011.06.017  1
2011 Georgakopoulos A, Xu J, Xu C, Mauger G, Barthet G, Robakis NK. Presenilin1/gamma-secretase promotes the EphB2-induced phosphorylation of ephrinB2 by regulating phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk binding protein. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 3594-604. PMID 21746865 DOI: 10.1096/fj.11-187856  1
2011 Roussos P, Giakoumaki SG, Georgakopoulos A, Robakis NK, Bitsios P. The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males. Bipolar Disorders. 13: 250-9. PMID 21676128 DOI: 10.1111/j.1399-5618.2011.00924.x  1
2011 Barthet G, Shioi J, Shao Z, Ren Y, Georgakopoulos A, Robakis NK. Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 2937-46. PMID 21597003 DOI: 10.1096/fj.11-183806  1
2011 Roussos P, Giakoumaki SG, Adamaki E, Georgakopoulos A, Anastasios G, Robakis NK, Nikos RK, Bitsios P. The association of schizophrenia risk D-amino acid oxidase polymorphisms with sensorimotor gating, working memory and personality in healthy males. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 1677-88. PMID 21471957 DOI: 10.1038/npp.2011.49  0.32
2011 Michailidis IE, Rusinova R, Georgakopoulos A, Chen Y, Iyengar R, Robakis NK, Logothetis DE, Baki L. Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation. PflüGers Archiv : European Journal of Physiology. 461: 387-97. PMID 21107857 DOI: 10.1007/s00424-010-0904-3  1
2011 Robakis NK. Mechanisms of AD neurodegeneration may be independent of Aβ and its derivatives. Neurobiology of Aging. 32: 372-9. PMID 20594619 DOI: 10.1016/j.neurobiolaging.2010.05.022  1
2010 Pimplikar SW, Nixon RA, Robakis NK, Shen J, Tsai LH. Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 14946-54. PMID 21068297 DOI: 10.1523/JNEUROSCI.4305-10.2010  1
2010 Robakis NK. Are Abeta and its derivatives causative agents or innocent bystanders in AD? Neuro-Degenerative Diseases. 7: 32-7. PMID 20160455 DOI: 10.1159/000266476  1
2010 Robakis NK. Alzheimer's disease: new light on etiology and management. The Mount Sinai Journal of Medicine, New York. 77: 1-2. PMID 20101717 DOI: 10.1002/msj.20166  1
2009 Xu J, Litterst C, Georgakopoulos A, Zaganas I, Robakis NK. Peptide EphB2/CTF2 generated by the gamma-secretase processing of EphB2 receptor promotes tyrosine phosphorylation and cell surface localization of N-methyl-D-aspartate receptors. The Journal of Biological Chemistry. 284: 27220-8. PMID 19661068 DOI: 10.1074/jbc.M109.048728  1
2009 Eder-Colli L, Abad-Estarlich N, Pannetier C, Vallet PG, Walzer C, Elder GA, Robakis NK, Bouras C, Savioz A. The presenilin-1 familial Alzheimer's disease mutation P117L decreases neuronal differentiation of embryonic murine neural progenitor cells. Brain Research Bulletin. 80: 296-301. PMID 19555743 DOI: 10.1016/j.brainresbull.2009.06.007  1
2009 Tezapsidis N, Johnston JM, Smith MA, Ashford JW, Casadesus G, Robakis NK, Wolozin B, Perry G, Zhu X, Greco SJ, Sarkar S. Leptin: a novel therapeutic strategy for Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 16: 731-40. PMID 19387109 DOI: 10.3233/JAD-2009-1021  1
2009 Kouchi Z, Barthet G, Serban G, Georgakopoulos A, Shioi J, Robakis NK. p120 catenin recruits cadherins to gamma-secretase and inhibits production of Abeta peptide. The Journal of Biological Chemistry. 284: 1954-61. PMID 19008223 DOI: 10.1074/jbc.M806250200  1
2008 Baki L, Neve RL, Shao Z, Shioi J, Georgakopoulos A, Robakis NK. Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase neuroprotective signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 483-90. PMID 18184791 DOI: 10.1523/JNEUROSCI.4067-07.2008  1
2007 Fassa A, Parisiadou L, Robakis NK, Efthimiopoulos S. Novel processing of Notch 1 within its intracellular domain by a cysteine protease. Neuro-Degenerative Diseases. 4: 148-55. PMID 17596709 DOI: 10.1159/000101839  1
2007 Litterst C, Georgakopoulos A, Shioi J, Ghersi E, Wisniewski T, Wang R, Ludwig A, Robakis NK. Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor. The Journal of Biological Chemistry. 282: 16155-63. PMID 17428795 DOI: 10.1074/jbc.M611449200  1
2007 Shioi J, Georgakopoulos A, Mehta P, Kouchi Z, Litterst CM, Baki L, Robakis NK. FAD mutants unable to increase neurotoxic Abeta 42 suggest that mutation effects on neurodegeneration may be independent of effects on Abeta. Journal of Neurochemistry. 101: 674-81. PMID 17254019 DOI: 10.1111/j.1471-4159.2006.04391.x  1
2007 Robakis NK. Alzheimer research forum discussion: Gain or loss of function - Time to shake up assumptions on γ-secretase in Alzheimer disease? Commentary Journal of Alzheimer's Disease. 11: 401.  1
2006 Robakis NK. The discovery and mapping to chromosome 21 of the Alzheimer's amyloid gene: history revised. Journal of Alzheimer's Disease : Jad. 10: 453-5. PMID 17183160  1
2006 Arnaud L, Robakis NK, Figueiredo-Pereira ME. It may take inflammation, phosphorylation and ubiquitination to 'tangle' in Alzheimer's disease. Neuro-Degenerative Diseases. 3: 313-9. PMID 16954650 DOI: 10.1159/000095638  1
2006 Georgakopoulos A, Litterst C, Ghersi E, Baki L, Xu C, Serban G, Robakis NK. Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling. The Embo Journal. 25: 1242-52. PMID 16511561 DOI: 10.1038/sj.emboj.7601031  1
2006 Agiostratidou G, Muros RM, Shioi J, Marambaud P, Robakis NK. The cytoplasmic sequence of E-cadherin promotes non-amyloidogenic degradation of A beta precursors. Journal of Neurochemistry. 96: 1182-8. PMID 16417575 DOI: 10.1111/j.1471-4159.2005.03616.x  1
2006 Robakis NK, Marambaud P. The Presenilin/γ-Secretase Complex Regulates Production of Transcriptional Factors: Effects of FAD Mutations Transcription Factors in the Nervous System: Development, Brain Function, and Diseases. 398-416. DOI: 10.1002/3527608036.ch19  1
2005 Serban G, Kouchi Z, Baki L, Georgakopoulos A, Litterst CM, Shioi J, Robakis NK. Cadherins mediate both the association between PS1 and beta-catenin and the effects of PS1 on beta-catenin stability. The Journal of Biological Chemistry. 280: 36007-12. PMID 16126725 DOI: 10.1074/jbc.M507503200  1
2005 Marambaud P, Robakis NK. Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation. Genes, Brain, and Behavior. 4: 134-46. PMID 15810902 DOI: 10.1111/j.1601-183X.2005.00086.x  1
2004 Wen PH, Hof PR, Chen X, Gluck K, Austin G, Younkin SG, Younkin LH, DeGasperi R, Gama Sosa MA, Robakis NK, Haroutunian V, Elder GA. The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice. Experimental Neurology. 188: 224-37. PMID 15246822 DOI: 10.1016/j.expneurol.2004.04.002  1
2004 Baki L, Shioi J, Wen P, Shao Z, Schwarzman A, Gama-Sosa M, Neve R, Robakis NK. PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. The Embo Journal. 23: 2586-96. PMID 15192701 DOI: 10.1038/sj.emboj.7600251  1
2004 Umehara Y, Yamada S, Nishimura S, Shioi J, Robakis NK, Sugahara K. Chondroitin sulfate of appican, the proteoglycan form of amyloid precursor protein, produced by C6 glioma cells interacts with heparin-binding neuroregulatory factors. Febs Letters. 557: 233-8. PMID 14741373 DOI: 10.1016/S0014-5793(03)01506-0  1
2003 Qin W, Ho L, Pompl PN, Peng Y, Zhao Z, Xiang Z, Robakis NK, Shioi J, Suh J, Pasinetti GM. Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity. The Journal of Biological Chemistry. 278: 50970-7. PMID 14507922 DOI: 10.1074/jbc.M307699200  1
2003 Marambaud P, Wen PH, Dutt A, Shioi J, Takashima A, Siman R, Robakis NK. A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Cell. 114: 635-45. PMID 13678586 DOI: 10.1016/j.cell.2003.08.008  1
2003 Robakis NK. An Alzheimer's disease hypothesis based on transcriptional dysregulation. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 10: 80-5. PMID 12964415  1
2002 Wen PH, Shao X, Shao Z, Hof PR, Wisniewski T, Kelley K, Friedrich VL, Ho L, Pasinetti GM, Shioi J, Robakis NK, Elder GA. Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice. Neurobiology of Disease. 10: 8-19. PMID 12079399 DOI: 10.1006/nbdi.2002.0490  1
2002 Bussière T, Friend PD, Sadeghi N, Wicinski B, Lin GI, Bouras C, Giannakopoulos P, Robakis NK, Morrison JH, Perl DP, Hof PR. Stereologic assessment of the total cortical volume occupied by amyloid deposits and its relationship with cognitive status in aging and Alzheimer's disease. Neuroscience. 112: 75-91. PMID 12044473 DOI: 10.1016/S0306-4522(02)00056-8  1
2002 Marambaud P, Shioi J, Serban G, Georgakopoulos A, Sarner S, Nagy V, Baki L, Wen P, Efthimiopoulos S, Shao Z, Wisniewski T, Robakis NK. A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. The Embo Journal. 21: 1948-56. PMID 11953314 DOI: 10.1093/emboj/21.8.1948  1
2002 Wen PH, Friedrich VL, Shioi J, Robakis NK, Elder GA. Presenilin-1 is expressed in neural progenitor cells in the hippocampus of adult mice. Neuroscience Letters. 318: 53-6. PMID 11796184 DOI: 10.1016/S0304-3940(01)02485-5  1
2001 Tsuchida K, Shioi J, Yamada S, Boghosian G, Wu A, Cai H, Sugahara K, Robakis NK. Appican, the proteoglycan form of the amyloid precursor protein, contains chondroitin sulfate E in the repeating disaccharide region and 4-O-sulfated galactose in the linkage region. The Journal of Biological Chemistry. 276: 37155-60. PMID 11479316 DOI: 10.1074/jbc.M105818200  1
2001 Baki L, Marambaud P, Efthimiopoulos S, Georgakopoulos A, Wen P, Cui W, Shioi J, Koo E, Ozawa M, Friedrich VL, Robakis NK. Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex. Proceedings of the National Academy of Sciences of the United States of America. 98: 2381-6. PMID 11226248 DOI: 10.1073/pnas.041603398  1
2000 Georgakopoulos A, Marambaud P, Friedrich VL, Shioi J, Efthimiopoulos S, Robakis NK. Presenilin-1: a component of synaptic and endothelial adherens junctions. Annals of the New York Academy of Sciences. 920: 209-14. PMID 11193152  1
2000 Blitzer RD, Wong T, Giovannini MG, Pangalos MN, Robakis NK, Landau EM. Amyloid beta peptides activate the phosphoinositide signaling pathway in oocytes expressing rat brain RNA. Brain Research. Molecular Brain Research. 76: 115-20. PMID 10719221 DOI: 10.1016/S0169-328X(99)00340-X  1
1999 Omar RA, Chyan YJ, Andorn AC, Poeggeler B, Robakis NK, Pappolla MA. Increased Expression but Reduced Activity of Antioxidant Enzymes in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. 1: 139-145. PMID 12213999  1
1999 Georgakopoulos A, Marambaud P, Efthimiopoulos S, Shioi J, Cui W, Li HC, Schütte M, Gordon R, Holstein GR, Martinelli G, Mehta P, Friedrich VL, Robakis NK. Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts. Molecular Cell. 4: 893-902. PMID 10635315  1
1999 Giannakopoulos P, Kövari E, Buée L, Shioi J, Hof PR, Robakis NK, Bouras C. Presenilin-1 expression in Pick's disease. Acta Neuropathologica. 98: 488-92. PMID 10541872 DOI: 10.1007/s004010051114  1
1999 Robakis NK, Efthimiopoulos S. Familial Alzheimer disease: changes in Abeta production may indicate a disturbance in protein transport or function caused by pleiotropic effects of FAD mutations. Neurobiology of Aging. 20: 81-3; discussion 87. PMID 10466898 DOI: 10.1016/S0197-4580(99)00011-1  1
1999 Jung MY, Skryabin BV, Arai M, Abbondanzo S, Fu D, Brosius J, Robakis NK, Polites HG, Pintar JE, Schmauss C. Potentiation of the D2 mutant motor phenotype in mice lacking dopamine D2 and D3 receptors. Neuroscience. 91: 911-24. PMID 10391470 DOI: 10.1016/S0306-4522(98)00705-2  1
1999 Figueiredo-Pereira ME, Efthimiopoulos S, Tezapsidis N, Buku A, Ghiso J, Mehta P, Robakis NK. Distinct secretases, a cysteine protease and a serine protease, generate the C termini of amyloid beta-proteins Abeta1-40 and Abeta1-42, respectively. Journal of Neurochemistry. 72: 1417-22. PMID 10098844 DOI: 10.1046/j.1471-4159.1999.721417.x  1
1999 Hook VY, Sei C, Yasothornsrikul S, Toneff T, Kang YH, Efthimiopoulos S, Robakis NK, Van Nostrand W. The kunitz protease inhibitor form of the amyloid precursor protein (KPI/APP) inhibits the proneuropeptide processing enzyme prohormone thiol protease (PTP). Colocalization of KPI/APP and PTP in secretory vesicles. The Journal of Biological Chemistry. 274: 3165-72. PMID 9915856 DOI: 10.1074/jbc.274.5.3165  1
1998 Efthimiopoulos S, Floor E, Georgakopoulos A, Shioi J, Cui W, Yasothornsrikul S, Hook VY, Wisniewski T, Buee L, Robakis NK. Enrichment of presenilin 1 peptides in neuronal large dense-core and somatodendritic clathrin-coated vesicles. Journal of Neurochemistry. 71: 2365-72. PMID 9832134 DOI: 10.1046/j.1471-4159.1998.71062365.x  1
1998 Bursztajn S, DeSouza R, McPhie DL, Berman SA, Shioi J, Robakis NK, Neve RL. Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 9790-9. PMID 9822738  1
1998 Pappolla M, Bozner P, Soto C, Shao H, Robakis NK, Zagorski M, Frangione B, Ghiso J. Inhibition of Alzheimer beta-fibrillogenesis by melatonin. The Journal of Biological Chemistry. 273: 7185-8. PMID 9516407 DOI: 10.1074/jbc.273.13.7185  1
1998 Tezapsidis N, Li HC, Ripellino JA, Efthimiopoulos S, Vassilacopoulou D, Sambamurti K, Toneff T, Yasothornsrikul S, Hook VY, Robakis NK. Release of nontransmembrane full-length Alzheimer's amyloid precursor protein from the lumenar surface of chromaffin granule membranes. Biochemistry. 37: 1274-82. PMID 9477953 DOI: 10.1021/bi9714159  1
1998 Neve RL, Robakis NK. Alzheimer's disease: a re-examination of the amyloid hypothesis. Trends in Neurosciences. 21: 15-9. PMID 9464679 DOI: 10.1016/S0166-2236(97)01168-5  1
1997 Wu A, Pangalos MN, Efthimiopoulos S, Shioi J, Robakis NK. Appican expression induces morphological changes in C6 glioma cells and promotes adhesion of neural cells to the extracellular matrix. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 4987-93. PMID 9185536  1
1997 Giannakopoulos P, Bouras C, Kövari E, Shioi J, Tezapsidis N, Hof PR, Robakis NK. Presenilin-1-immunoreactive neurons are preserved in late-onset Alzheimer's disease. The American Journal of Pathology. 150: 429-36. PMID 9033258  1
1997 Pappolla MA, Sos M, Omar RA, Bick RJ, Hickson-Bick DL, Reiter RJ, Efthimiopoulos S, Robakis NK. Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 1683-90. PMID 9030627  1
1996 Pangalos MN, Shioi J, Efthimiopoulos S, Wu A, Robakis NK. Characterization of appican, the chondroitin sulfate proteoglycan form of the Alzheimer amyloid precursor protein. Neurodegeneration : a Journal For Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration. 5: 445-51. PMID 9117561 DOI: 10.1006/neur.1996.0061  1
1996 Elder GA, Tezapsidis N, Carter J, Shioi J, Bouras C, Li HC, Johnston JM, Efthimiopoulos S, Friedrich VL, Robakis NK. Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains. Journal of Neuroscience Research. 45: 308-20. PMID 8841992 DOI: 10.1002/(SICI)1097-4547(19960801)45:3<308::AID-JNR13>3.0.CO;2-#  1
1996 Efthimiopoulos S, Punj S, Manolopoulos V, Pangalos M, Wang GP, Refolo LM, Robakis NK. Intracellular cyclic AMP inhibits constitutive and phorbol ester-stimulated secretory cleavage of amyloid precursor protein. Journal of Neurochemistry. 67: 872-5. PMID 8764618  1
1996 Efthimiopoulos S, Vassilacopoulou D, Ripellino JA, Tezapsidis N, Robakis NK. Cholinergic agonists stimulate secretion of soluble full-length amyloid precursor protein in neuroendocrine cells. Proceedings of the National Academy of Sciences of the United States of America. 93: 8046-50. PMID 8755600 DOI: 10.1073/pnas.93.15.8046  1
1996 Bouras C, Giannakopoulos P, Schioi J, Tezapsidis N, Robakis NK. Presenilin-1 polymorphism and Alzheimer's disease. Lancet. 347: 1185-6. PMID 8609782  1
1996 Shioi J, Pangalos MN, Wu A, Robakis NK. Structure and function of appican, the proteoglycan form of the alzheimer amyloid precursor Trends in Glycoscience and Glycotechnology. 8: 253-263.  1
1996 Kehoe P, Williams J, Lovestone S, Wilcock G, Owen MJ, Holmans P, Liddell M, Holmes C, Powall J, Neal J, Bouras C, Giannakopoulos P, Schioi J, Tezapsidis N, Robakis NK, et al. Presenilin-1 polymorphism and Alzheimer's disease [6] Lancet. 347: 185-187.  1
1995 Shioi J, Pangalos MN, Ripellino JA, Vassilacopoulou D, Mytilineou C, Margolis RU, Robakis NK. The Alzheimer amyloid precursor proteoglycan (appican) is present in brain and is produced by astrocytes but not by neurons in primary neural cultures. The Journal of Biological Chemistry. 270: 11839-44. PMID 7744833 DOI: 10.1074/jbc.270.20.11839  1
1995 Pangalos MN, Efthimiopoulos S, Shioi J, Robakis NK. The chondroitin sulfate attachment site of appican is formed by splicing out exon 15 of the amyloid precursor gene. The Journal of Biological Chemistry. 270: 10388-91. PMID 7737970 DOI: 10.1074/jbc.270.18.10388  1
1995 Vassilacopoulou D, Ripellino JA, Tezapsidis N, Hook VY, Robakis NK. Full-length and truncated Alzheimer amyloid precursors in chromaffin granules: solubilization of membrane amyloid precursor is mediated by an enzymatic mechanism. Journal of Neurochemistry. 64: 2140-6. PMID 7722498  1
1995 Pappolla MA, Sambamurti K, Efthimiopoulos S, Refolo L, Omar RA, Robakis NK. Heat-shock induces abnormalities in the cellular distribution of amyloid precursor protein (APP) and APP fusion proteins. Neuroscience Letters. 192: 105-8. PMID 7675314 DOI: 10.1016/0304-3940(95)11627-9  1
1995 Pangalos MN, Shioi J, Robakis NK. Expression of the chondroitin sulfate proteoglycans of amyloid precursor (appican) and amyloid precursor-like protein 2. Journal of Neurochemistry. 65: 762-9. PMID 7616233  1
1995 Refolo LM, Sambamurti K, Efthimiopoulos S, Pappolla MA, Robakis NK. Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization. Journal of Neuroscience Research. 40: 694-706. PMID 7602619 DOI: 10.1002/jnr.490400515  1
1995 Fu D, Skryabin BV, Brosius J, Robakis NK. Molecular cloning and characterization of the mouse dopamine D3 receptor gene: an additional intron and an mRNA variant. Dna and Cell Biology. 14: 485-92. PMID 7598803  1
1995 Robakis NK. Molecular biology of Alzheimer's disease pathology Journal of Neuropathology and Experimental Neurology. 54: 16S-17S.  1
1994 Roberts SB, Ripellino JA, Ingalls KM, Robakis NK, Felsenstein KM. Non-amyloidogenic cleavage of the beta-amyloid precursor protein by an integral membrane metalloendopeptidase. The Journal of Biological Chemistry. 269: 3111-6. PMID 8300647  1
1994 Shashidharan P, Michaelidis TM, Robakis NK, Kresovali A, Papamatheakis J, Plaitakis A. Novel human glutamate dehydrogenase expressed in neural and testicular tissues and encoded by an X-linked intronless gene. The Journal of Biological Chemistry. 269: 16971-6. PMID 8207021  1
1994 Efthimiopoulos S, Felsenstein KM, Sambamurti K, Robakis NK, Refolo LM. Study of the phorbol ester effect on Alzheimer amyloid precursor processing: sequence requirements and involvement of a cholera toxin sensitive protein. Journal of Neuroscience Research. 38: 81-90. PMID 8057394 DOI: 10.1002/jnr.490380111  1
1994 Robakis NK, Pappolla MA. Oxygen-free radicals and amyloidosis in Alzheimer's disease: is there a connection? Neurobiology of Aging. 15: 457-9; discussion 47. PMID 7969722 DOI: 10.1016/0197-4580(94)90077-9  1
1994 Robakis NK, Pangalos MN. Involvement of amyloid as a central step in the development of Alzheimer's disease. Neurobiology of Aging. 15: S127-9. PMID 7700436 DOI: 10.1016/0197-4580(94)90189-9  1
1994 Ripellino JA, Vassilacopoulou D, Robakis NK. Solubilization of full-length amyloid precursor proteins from PC12 cell membranes. Journal of Neuroscience Research. 39: 211-8. PMID 7530778 DOI: 10.1002/jnr.490390211  1
1993 Shioi J, Refolo LM, Efthimiopoulos S, Robakis NK. Chondroitin sulfate proteoglycan form of cellular and cell-surface Alzheimer amyloid precursor. Neuroscience Letters. 154: 121-4. PMID 8361624 DOI: 10.1016/0304-3940(93)90186-O  1
1993 Buée L, Ding W, Anderson JP, Narindrasorasak S, Kisilevsky R, Boyle NJ, Robakis NK, Delacourte A, Greenberg B, Fillit HM. Binding of vascular heparan sulfate proteoglycan to Alzheimer's amyloid precursor protein is mediated in part by the N-terminal region of A4 peptide. Brain Research. 627: 199-204. PMID 8298962 DOI: 10.1016/0006-8993(93)90321-D  1
1993 Robakis NK, Vassilacopoulou D, Efthimiopoulos S, Sambamurti K, Refolo LM, Shioi J. Cellular processing and proteoglycan nature of amyloid precursor proteins. Annals of the New York Academy of Sciences. 695: 132-8. PMID 8239271 DOI: 10.1111/j.1749-6632.1993.tb23041.x  1
1992 Shioi J, Anderson JP, Ripellino JA, Robakis NK. Chondroitin sulfate proteoglycan form of the Alzheimer's beta-amyloid precursor. The Journal of Biological Chemistry. 267: 13819-22. PMID 1629183  1
1992 Sambamurti K, Shioi J, Anderson JP, Pappolla MA, Robakis NK. Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells. Journal of Neuroscience Research. 33: 319-29. PMID 1453494 DOI: 10.1002/jnr.490330216  1
1992 Pappolla MA, Omar RA, Sambamurti K, Anderson JP, Robakis NK. The genesis of the senile plaque. Further evidence in support of its neuronal origin. The American Journal of Pathology. 141: 1151-9. PMID 1443049  1
1992 Anderson JP, Chen Y, Kim KS, Robakis NK. An alternative secretase cleavage produces soluble Alzheimer amyloid precursor protein containing a potentially amyloidogenic sequence. Journal of Neurochemistry. 59: 2328-31. PMID 1431910  1
1992 Vallet PG, Guntern R, Hof PR, Golaz J, Delacourte A, Robakis NK, Bouras C. A comparative study of histological and immunohistochemical methods for neurofibrillary tangles and senile plaques in Alzheimer's disease. Acta Neuropathologica. 83: 170-8. PMID 1373017 DOI: 10.1007/BF00308476  1
1992 Pappolla MA, Omar RA, Kim KS, Robakis NK. Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease. The American Journal of Pathology. 140: 621-8. PMID 1372157  1
1992 Roch JM, Shapiro IP, Sundsmo MP, Otero DA, Refolo LM, Robakis NK, Saitoh T. Bacterial expression, purification, and functional mapping of the amyloid beta/A4 protein precursor. The Journal of Biological Chemistry. 267: 2214-21. PMID 1346393  0.36
1992 Sambamurti K, Refolo LM, Shioi J, Pappolla MA, Robakis NK. The Alzheimer's amyloid precursor is cleaved intracellularly in the trans-Golgi network or in a post-Golgi compartment. Annals of the New York Academy of Sciences. 674: 118-28. PMID 1283818  1
1992 Roch JM, Shapiro IP, Sundsmo MP, Otero DAC, Refolo LM, Robakis NK, Saitoh T. Bacterial expression, purification, and functional mapping of the amyloid β/A4 protein precursor Journal of Biological Chemistry. 267: 2214-2221.  1
1991 Anderson JP, Esch FS, Keim PS, Sambamurti K, Lieberburg I, Robakis NK. Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells. Neuroscience Letters. 128: 126-8. PMID 1922940 DOI: 10.1016/0304-3940(91)90775-O  1
1991 Robakis NK, Anderson JP, Refolo LM, Wallace W. Expression of the Alzheimer amyloid precursor in brain tissue and effects of NGF and EGF on its metabolism. Clinical Neuropharmacology. 14: S15-23. PMID 1913706  1
1991 Lahiri DK, Robakis NK. The promoter activity of the gene encoding Alzheimer beta-amyloid precursor protein (APP) is regulated by two blocks of upstream sequences. Brain Research. Molecular Brain Research. 9: 253-7. PMID 1851527 DOI: 10.1016/0169-328X(91)90009-M  1
1991 Probst A, Langui D, Ipsen S, Robakis N, Ulrich J. Deposition of beta/A4 protein along neuronal plasma membranes in diffuse senile plaques. Acta Neuropathologica. 83: 21-9. PMID 1724335 DOI: 10.1007/BF00294426  1
1991 Refolo LM, Wittenberg IS, Friedrich VL, Robakis NK. The Alzheimer amyloid precursor is associated with the detergent-insoluble cytoskeleton. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 11: 3888-97. PMID 1683901  1
1991 Wallace WC, Bragin V, Robakis NK, Sambamurti K, VanderPutten D, Merril CR, Davis KL, Santucci AC, Haroutunian V. Increased biosynthesis of Alzheimer amyloid precursor protein in the cerebral cortex of rats with lesions of the nucleus basalis of Meynert. Brain Research. Molecular Brain Research. 10: 173-8. PMID 1649369 DOI: 10.1016/0169-328X(91)90108-A  1
1990 Robakis NK, Mohamadi M, Fu DY, Sambamurti K, Refolo LM. Human retina D2 receptor cDNAs have multiple polyadenylation sites and differ from a pituitary clone at the 5' non-coding region. Nucleic Acids Research. 18: 1299. PMID 2138729  1
1990 Berkenbosch F, Refolo LM, Friedrich VL, Casper D, Blum M, Robakis NK. The Alzheimer's amyloid precursor protein is produced by type I astrocytes in primary cultures of rat neuroglia. Journal of Neuroscience Research. 25: 431-40. PMID 2109094 DOI: 10.1002/jnr.490250321  1
1990 Brown HR, Goller NL, Rudelli RD, Merz GS, Wolfe GC, Wisniewski HM, Robakis NK. The mRNA encoding the scrapie agent protein is present in a variety of non-neuronal cells. Acta Neuropathologica. 80: 1-6. PMID 1972856 DOI: 10.1007/BF00294214  1
1990 Harris MS, Devine-Gage E, Robakis NK. An AluI RFLP detected in the human prion protein (PrP) gene. Nucleic Acids Research. 18: 385. PMID 1970165 DOI: 10.1093/nar/18.2.385-a  1
1990 Harris MS, Devine-Gage E, Robakis NK. An Alul RFLP detected in the human prion protein (PrP) gene Nucleic Acids Research. 18: 385.  1
1990 Robakis NK, Altstiel LD, Refolo LM, Anderson JP. Function and metabolism of the protease inhibitor-containing Alzheimer amyloid precursors Molecular Biology and Genetics of Alzheimer's Disease: Proceedings of the International Symposium On Dementia: Molecular Biology and Genetics of Alzheimer's Disease. Ics884. 179-188.  1
1989 Jenkins EC, Devine-Gage EA, Yao XL, Houck GE, Brown WT, Robakis NK, Wisniewski KE, Silverman WP, Reisberg B, Wisniewski HM. Beta-amyloid protein probe hybridized to chromosome 9 in 3 Alzheimer disease individuals. Progress in Clinical and Biological Research. 317: 269-75. PMID 2690102  1
1989 Anderson JP, Refolo LM, Wallace W, Mehta P, Krishnamurthi M, Gotlib J, Bierer L, Haroutunian V, Perl D, Robakis NK. Differential brain expression of the Alzheimer's amyloid precursor protein. The Embo Journal. 8: 3627-32. PMID 2583112  1
1989 La Fauci G, Lahiri DK, Salton SR, Robakis NK. Characterization of the 5'-end region and the first two exons of the beta-protein precursor gene. Biochemical and Biophysical Research Communications. 159: 297-304. PMID 2538123 DOI: 10.1016/0006-291X(89)92437-6  1
1989 Refolo LM, Salton SR, Anderson JP, Mehta P, Robakis NK. Nerve and epidermal growth factors induce the release of the Alzheimer amyloid precursor from PC 12 cell cultures. Biochemical and Biophysical Research Communications. 164: 664-70. PMID 2510719 DOI: 10.1016/0006-291X(89)91511-8  1
1988 Jenkins EC, Devine-Gage EA, Robakis NK, Yao XL, Brown WT, Houck GE, Wolfe G, Ramakrishna N, Silverman WP, Wisniewski HM. Fine mapping of an Alzheimer disease-associated gene encoding beta-amyloid protein. Biochemical and Biophysical Research Communications. 151: 1-8. PMID 3279948 DOI: 10.1016/0006-291X(88)90551-7  1
1988 Wu Y, Dobkin C, Devine-Gage E, Ramakrishna N, Brown WT, Wisniewski HM, Robakis NK. A high frequency NcoI RFLP detected in the Alzheimer amyloid peptide gene. Nucleic Acids Research. 16: 1647. PMID 2894637 DOI: 10.1093/nar/16.4.1647  1
1988 Devine-Gage EA, Jenkins EC, Brown WT, Robakis NK, Wisniewski HM. The genetics of Familial Alzheimer's Disease Age. 11: 98-102. DOI: 10.1007/BF02431747  1
1987 Robakis NK, Ramakrishna N, Wolfe G, Wisniewski HM. Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides. Proceedings of the National Academy of Sciences of the United States of America. 84: 4190-4. PMID 3035574  1
1987 Warren AC, Robakis NK, Ramakrishna N, Koo EH, Ross CA, Robb AS, Folstein MF, Price DL, Antonarakis SE. beta-Amyloid gene is not present in three copies in autopsy-validated Alzheimer's disease. Genomics. 1: 307-12. PMID 2966761 DOI: 10.1016/0888-7543(87)90029-2  1
1987 Reeves RH, Robakis NK, Oster-Granite ML, Wisniewski HM, Coyle JT, Gearhart JD. Genetic linkage in the mouse of genes involved in Down syndrome and Alzheimer's disease in man. Brain Research. 388: 215-21. PMID 2960420 DOI: 10.1016/0169-328X(87)90028-3  1
1987 Jenkins EC, Devine-Gage EA, Yao XL, Houck GE, Brown WT, Wisniewski HM, Robakis NK. In-situ hybridisation of the beta-amyloid protein probe to chromosome 9 in patients with familial Alzheimer's disease. Lancet. 2: 1155-6. PMID 2890057  0.44
1987 Wu Y, Brown WT, Robakis NK, Dobkin C, Devine-Gage E, Merz P, Wisniewski HM. A PvuII RFLP detected in the human prion protein (PrP) gene. Nucleic Acids Research. 15: 3191. PMID 2882483 DOI: 10.1093/nar/15.7.3191  1
1987 Robakis NK, Wisniewski HM, Jenkins EC, Devine-Gage EA, Houck GE, Yao XL, Ramakrishna N, Wolfe G, Silverman WP, Brown WT. Chromosome 21q21 sublocalisation of gene encoding beta-amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer disease and Down syndrome. Lancet. 1: 384-5. PMID 2880184  0.44
1987 David F, Robakis NK, Lucotte G. A new TaqI polymorphism detected by the cDNA encoding amyloid beta protein of alzhemer's disease Nucleic Acids Research. 15: 9103. DOI: 10.1093/nar/15.21.9103  1
1986 Robakis NK, Sawh PR, Wolfe GC, Rubenstein R, Carp RI, Innis MA. Isolation of a cDNA clone encoding the leader peptide of prion protein and expression of the homologous gene in various tissues. Proceedings of the National Academy of Sciences of the United States of America. 83: 6377-81. PMID 3529083 DOI: 10.1073/pnas.83.17.6377  1
1986 Robakis NK, Devine-Gage EA, Jenkins EC, Kascsak RJ, Brown WT, Krawczun MS, Silverman WP. Localization of a human gene homologous to the PrP gene on the p arm of chromosome 20 and detection of PrP-related antigens in normal human brain. Biochemical and Biophysical Research Communications. 140: 758-65. PMID 2877664 DOI: 10.1016/0006-291X(86)90796-5  1
1986 Kascsak RJ, Rubenstein R, Merz PA, Carp RI, Robakis NK, Wisniewski HM, Diringer H. Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains. Journal of Virology. 59: 676-83. PMID 2426470  1
1986 Rubenstein R, Kascsak RJ, Merz PA, Papini MC, Carp RI, Robakis NK, Wisniewski HM. Detection of scrapie-associated fibril (SAF) proteins using anti-SAF antibody in non-purified tissue preparations. The Journal of General Virology. 67: 671-81. PMID 2420924  1
1985 Robakis NK, Palleroni NJ, Despreaux CW. Isolation and characterization of two phages of Gluconobacter oxydans Journal of General Microbiology. 131: 2467-2473.  1
1985 Robakis NK, Palleroni NJ, Boublik M, Despreaux CW. Construction of a restriction map of the Gluconobacter bacteriophage A-1 genome Journal of General Microbiology. 131: 2475-2477.  1
1983 Robakis NK, Rossman TG, Shapiro R, Szer W. The effects of bisulfite on growth and macromolecular synthesis in Escherichia coli. Chemico-Biological Interactions. 43: 289-98. PMID 6402316 DOI: 10.1016/0009-2797(83)90113-8  1
1983 Robakis NK, Shapiro R, Szer W. Reversal of growth inhibition in Escherichia coli by bisulfite. Chemico-Biological Interactions. 43: 299-311. PMID 6337733 DOI: 10.1016/0009-2797(83)90114-X  1
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