Kelvin Luk - Publications

McGill University, Montreal, QC, Canada 

23 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Steinkellner T, Conrad WS, Kovacs I, Rissman RA, Lee EB, Trojanowski JQ, Freyberg Z, Roy S, Luk KC, Lee VM, Hnasko TS. Dopamine neurons exhibit emergent glutamatergic identity in Parkinson's disease. Brain : a Journal of Neurology. PMID 35258081 DOI: 10.1093/brain/awab373  0.447
2020 Wu Q, Shaikh MA, Meymand ES, Zhang B, Luk KC, Trojanowski JQ, Lee VM. Neuronal activity modulates alpha-synuclein aggregation and spreading in organotypic brain slice cultures and in vivo. Acta Neuropathologica. PMID 33021680 DOI: 10.1007/s00401-020-02227-6  0.399
2020 Chmielarz P, Er Ş, Konovalova J, Bandres L, Hlushchuk I, Albert K, Panhelainen A, Luk K, Airavaara M, Domanskyi A. GDNF/RET Signaling Pathway Activation Eliminates Lewy Body Pathology in Midbrain Dopamine Neurons. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 32964492 DOI: 10.1002/Mds.28258  0.463
2020 Hoban DB, Shrigley S, Mattsson B, Breger LS, Jarl U, Cardoso T, Nelander Wahlestedt J, Luk KC, Björklund A, Parmar M. Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD. Proceedings of the National Academy of Sciences of the United States of America. PMID 32541058 DOI: 10.1073/Pnas.2001305117  0.336
2019 Wong YC, Luk K, Purtell K, Burke Nanni S, Stoessl AJ, Trudeau LE, Yue Z, Krainc D, Oertel W, Obeso JA, Volpicelli-Daley LA. Neuronal vulnerability in Parkinson disease: Should the focus be on axons and synaptic terminals? Movement Disorders : Official Journal of the Movement Disorder Society. PMID 31483900 DOI: 10.1002/Mds.27823  0.44
2019 Luk KC. Oxidative stress and α-synuclein conspire in vulnerable neurons to promote Parkinson's disease progression. The Journal of Clinical Investigation. 130. PMID 31380806 DOI: 10.1172/JCI130351  0.339
2018 Luna E, Decker SC, Riddle DM, Caputo A, Zhang B, Cole T, Caswell C, Xie SX, Lee VMY, Luk KC. Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity. Acta Neuropathologica. PMID 29502200 DOI: 10.1007/S00401-018-1829-8  0.439
2017 Tapias V, Hu X, Luk KC, Sanders LH, Lee VM, Timothy Greenamyre J. Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production. Cellular and Molecular Life Sciences : Cmls. PMID 28534083 DOI: 10.1007/S00018-017-2541-X  0.358
2015 Osterberg VR, Spinelli KJ, Weston LJ, Luk KC, Woltjer RL, Unni VK. Progressive aggregation of alpha-synuclein and selective degeneration of lewy inclusion-bearing neurons in a mouse model of parkinsonism. Cell Reports. 10: 1252-60. PMID 25732816 DOI: 10.1016/j.celrep.2015.01.060  0.317
2014 Volpicelli-Daley LA, Luk KC, Lee VM. Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates. Nature Protocols. 9: 2135-46. PMID 25122523 DOI: 10.1038/Nprot.2014.143  0.334
2014 Tran HT, Chung CH, Iba M, Zhang B, Trojanowski JQ, Luk KC, Lee VM. Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration. Cell Reports. 7: 2054-65. PMID 24931606 DOI: 10.1016/J.Celrep.2014.05.033  0.387
2013 Luk KC, Rymar VV, van den Munckhof P, Nicolau S, Steriade C, Bifsha P, Drouin J, Sadikot AF. The transcription factor Pitx3 is expressed selectively in midbrain dopaminergic neurons susceptible to neurodegenerative stress. Journal of Neurochemistry. 125: 932-43. PMID 23331067 DOI: 10.1111/Jnc.12160  0.63
2012 Luk KC, Kehm V, Carroll J, Zhang B, O'Brien P, Trojanowski JQ, Lee VM. Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science (New York, N.Y.). 338: 949-53. PMID 23161999 DOI: 10.1126/Science.1227157  0.419
2011 Volpicelli-Daley LA, Luk KC, Patel TP, Tanik SA, Riddle DM, Stieber A, Meaney DF, Trojanowski JQ, Lee VM. Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death. Neuron. 72: 57-71. PMID 21982369 DOI: 10.1016/J.Neuron.2011.08.033  0.372
2008 Gandhi R, Luk KC, Rymar VV, Sadikot AF. Group I mGluR5 metabotropic glutamate receptors regulate proliferation of neuronal progenitors in specific forebrain developmental domains. Journal of Neurochemistry. 104: 155-72. PMID 17944877 DOI: 10.1111/J.1471-4159.2007.04955.X  0.622
2005 Landau AM, Luk KC, Jones ML, Siegrist-Johnstone R, Young YK, Kouassi E, Rymar VV, Dagher A, Sadikot AF, Desbarats J. Defective Fas expression exacerbates neurotoxicity in a model of Parkinson's disease. The Journal of Experimental Medicine. 202: 575-81. PMID 16129703 DOI: 10.1084/Jem.20050163  0.603
2005 Flores C, Manitt C, Rodaros D, Thompson KM, Rajabi H, Luk KC, Tritsch NX, Sadikot AF, Stewart J, Kennedy TE. Netrin receptor deficient mice exhibit functional reorganization of dopaminergic systems and do not sensitize to amphetamine. Molecular Psychiatry. 10: 606-12. PMID 15534618 DOI: 10.1038/Sj.Mp.4001607  0.58
2005 Rosa-Neto P, Goertzen AL, Diksic M, Dagher A, Mzengeza S, Soucy J, Luk KC, Rymar V, Sadikot AF, Evans AC. Dopamine D2/3 receptor binding in aphakia mice measured by microPET Journal of Cerebral Blood Flow & Metabolism. 25: S604-S604. DOI: 10.1038/Sj.Jcbfm.9591524.0604  0.54
2004 Luk KC, Sadikot AF. Glutamate and regulation of proliferation in the developing mammalian telencephalon. Developmental Neuroscience. 26: 218-28. PMID 15711062 DOI: 10.1159/000082139  0.583
2004 Rymar VV, Sasseville R, Luk KC, Sadikot AF. Neurogenesis and stereological morphometry of calretinin-immunoreactive GABAergic interneurons of the neostriatum. The Journal of Comparative Neurology. 469: 325-39. PMID 14730585 DOI: 10.1002/Cne.11008  0.576
2003 van den Munckhof P, Luk KC, Ste-Marie L, Montgomery J, Blanchet PJ, Sadikot AF, Drouin J. Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons. Development (Cambridge, England). 130: 2535-42. PMID 12702666 DOI: 10.1242/Dev.00464  0.629
2003 Luk KC, Kennedy TE, Sadikot AF. Glutamate promotes proliferation of striatal neuronal progenitors by an NMDA receptor-mediated mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 2239-50. PMID 12657683 DOI: 10.1523/Jneurosci.23-06-02239.2003  0.617
2001 Luk KC, Sadikot AF. GABA promotes survival but not proliferation of parvalbumin-immunoreactive interneurons in rodent neostriatum: An in vivo study with stereology Neuroscience. 104: 93-103. PMID 11311534 DOI: 10.1016/S0306-4522(01)00038-0  0.582
Show low-probability matches.