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Carmela R. Abraham, PhD, Harvard University - Publications

Biochemistry and Medicine Boston University, Boston, MA, United States 
Amyloidosis, Alzheimer disease

107 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Wolf EJ, Logue MW, Zhao X, Daskalakis NP, Morrison FG, Escarfulleri S, Stone A, Schichman SA, McGlinchey RE, Milberg WP, Chen C, Abraham CR, Miller MW. PTSD and the klotho longevity gene: Evaluation of longitudinal effects on inflammation via DNA methylation. Psychoneuroendocrinology. 117: 104656. PMID 32438247 DOI: 10.1016/j.psyneuen.2020.104656  0.32
2020 Chen CD, Rudy MA, Zeldich E, Abraham CR. A method to specifically activate the Klotho promoter by using zinc finger proteins constructed from modular building blocks and from naturally engineered Egr1 transcription factor backbone. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32347987 DOI: 10.1096/fj.202000171R  0.32
2020 Chen CD, Li Y, Chen AK, Rudy MA, Nasse JS, Zeldich E, Polanco TJ, Abraham CR. Identification of the cleavage sites leading to the shed forms of human and mouse anti-aging and cognition-enhancing protein Klotho. Plos One. 15: e0226382. PMID 31929539 DOI: 10.1371/journal.pone.0226382  0.32
2019 Zeldich E, Chen CD, Boden E, Howat B, Nasse JS, Zeldich D, Lambert AG, Yuste A, Cherry JD, Mathias RM, Ma Q, Lau NC, McKee AC, Hatzipetros T, Abraham CR. Klotho Is Neuroprotective in the Superoxide Dismutase (SOD1) Mouse Model of ALS. Journal of Molecular Neuroscience : Mn. PMID 31250273 DOI: 10.1007/s12031-019-01356-2  0.32
2019 Chen CD, Zeldich E, Khodr C, Camara K, Tung TY, Lauder EC, Mullen P, Polanco TJ, Liu YY, Zeldich D, Xia W, Van Nostrand WE, Brown LE, Porco JA, Abraham CR. Small Molecule Amyloid-β Protein Precursor Processing Modulators Lower Amyloid-β Peptide Levels via cKit Signaling. Journal of Alzheimer's Disease : Jad. 67: 1089-1106. PMID 30776010 DOI: 10.3233/JAD-180923  0.32
2018 Ikezu T, Chen C, DeLeo AM, Zeldich E, Fallin MD, Kanaan NM, Lunetta KL, Abraham CR, Logue MW, Farrer LA. Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 29516269 DOI: 10.1007/s11481-018-9781-x  0.32
2018 Robinson AA, Abraham CR, Rosene DL. Candidate molecular pathways of white matter vulnerability in the brain of normal aging rhesus monkeys. Geroscience. PMID 29357021 DOI: 10.1007/s11357-018-0006-2  0.4
2018 Chen CD, Zeldich E, Li Y, Yuste A, Abraham CR. Activation of the Anti-Aging and Cognition-Enhancing Gene Klotho by CRISPR-dCas9 Transcriptional Effector Complex. Journal of Molecular Neuroscience : Mn. PMID 29352444 DOI: 10.1007/s12031-017-1011-0  0.32
2015 Zeldich E, Chen CD, Avila R, Medicetty S, Abraham CR. The Anti-Aging Protein Klotho Enhances Remyelination Following Cuprizone-Induced Demyelination. Journal of Molecular Neuroscience : Mn. PMID 26067431 DOI: 10.1007/s12031-015-0598-2  1
2015 Chen CD, Li H, Liang J, Hixson K, Zeldich E, Abraham CR. The anti-aging and tumor suppressor protein Klotho enhances differentiation of a human oligodendrocytic hybrid cell line. Journal of Molecular Neuroscience : Mn. 55: 76-90. PMID 24907942 DOI: 10.1007/s12031-014-0336-1  1
2014 Chen CD, Tung TY, Liang J, Zeldich E, Tucker Zhou TB, Turk BE, Abraham CR. Identification of cleavage sites leading to the shed form of the anti-aging protein klotho. Biochemistry. 53: 5579-87. PMID 25110992 DOI: 10.1021/bi500409n  1
2014 Jun G, Asai H, Zeldich E, Drapeau E, Chen C, Chung J, Park JH, Kim S, Haroutunian V, Foroud T, Kuwano R, Haines JL, Pericak-Vance MA, Schellenberg GD, Lunetta KL, ... ... Abraham CR, et al. PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation. Annals of Neurology. 76: 379-92. PMID 25043464 DOI: 10.1002/ana.24219  1
2014 Zeldich E, Chen CD, Colvin TA, Bove-Fenderson EA, Liang J, Tucker Zhou TB, Harris DA, Abraham CR. The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. The Journal of Biological Chemistry. 289: 24700-15. PMID 25037225 DOI: 10.1074/jbc.M114.567321  1
2014 Dubal DB, Yokoyama JS, Zhu L, Broestl L, Worden K, Wang D, Sturm VE, Kim D, Klein E, Yu GQ, Ho K, Eilertson KE, Yu L, Kuro-o M, De Jager PL, ... ... Abraham CR, et al. Life extension factor klotho enhances cognition. Cell Reports. 7: 1065-76. PMID 24813892 DOI: 10.1016/j.celrep.2014.03.076  1
2014 Mehi SJ, Maltare A, Abraham CR, King GD. MicroRNA-339 and microRNA-556 regulate Klotho expression in vitro. Age (Dordrecht, Netherlands). 36: 141-9. PMID 23818104 DOI: 10.1007/s11357-013-9555-6  1
2013 Tucker Zhou TB, King GD, Chen C, Abraham CR. Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk. The Journal of Biological Chemistry. 288: 36302-11. PMID 24217253 DOI: 10.1074/jbc.M113.490052  1
2013 Chen CD, Sloane JA, Li H, Aytan N, Giannaris EL, Zeldich E, Hinman JD, Dedeoglu A, Rosene DL, Bansal R, Luebke JI, Kuro-o M, Abraham CR. The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 1927-39. PMID 23365232 DOI: 10.1523/JNEUROSCI.2080-12.2013  1
2013 McKee AC, Stern RA, Nowinski CJ, Stein TD, Alvarez VE, Daneshvar DH, Lee HS, Wojtowicz SM, Hall G, Baugh CM, Riley DO, Kubilus CA, Cormier KA, Jacobs MA, Martin BR, ... Abraham CR, et al. The spectrum of disease in chronic traumatic encephalopathy. Brain : a Journal of Neurology. 136: 43-64. PMID 23208308 DOI: 10.1093/brain/aws307  1
2013 Abraham CR, Nagle MW. Acylaminoacyl-Peptidase Handbook of Proteolytic Enzymes. 3: 3401-3403. DOI: 10.1016/B978-0-12-382219-2.00751-1  1
2012 Abraham CR, Chen C, Cuny GD, Glicksman MA, Zeldich E. Small-molecule Klotho enhancers as novel treatment of neurodegeneration. Future Medicinal Chemistry. 4: 1671-9. PMID 22924505 DOI: 10.4155/fmc.12.134  1
2012 So PP, Zeldich E, Seyb KI, Huang MM, Concannon JB, King GD, Chen CD, Cuny GD, Glicksman MA, Abraham CR. Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-β precursor protein dimerization. American Journal of Neurodegenerative Disease. 1: 75-87. PMID 22822474  1
2012 King GD, Chen C, Huang MM, Zeldich E, Brazee PL, Schuman ER, Robin M, Cuny GD, Glicksman MA, Abraham CR. Identification of novel small molecules that elevate Klotho expression. The Biochemical Journal. 441: 453-61. PMID 21939436 DOI: 10.1042/BJ20101909  1
2012 King GD, Rosene DL, Abraham CR. Promoter methylation and age-related downregulation of Klotho in rhesus monkey. Age (Dordrecht, Netherlands). 34: 1405-19. PMID 21922250 DOI: 10.1007/s11357-011-9315-4  1
2012 Erlich PM, Lunetta KL, Cupples LA, Abraham CR, Green RC, Baldwin CT, Farrer LA. Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease. Neurobiology of Aging. 33: 1015.e7-23. PMID 20980077 DOI: 10.1016/j.neurobiolaging.2010.08.003  1
2011 So PP, Chen CD, Abraham CR. Detection of amyloid-β protein precursor homo-interactions using beta-galactosidase enzyme fragment complementation. Journal of Alzheimer's Disease : Jad. 26: 647-55. PMID 21694460 DOI: 10.3233/JAD-2011-110323  1
2011 Abraham CR. Amyloid Beta Peptide and the Amyloid Cascade Hypothesis The Handbook of Alzheimer's Disease and Other Dementias. 262-276. DOI: 10.1002/9781444344110.ch8  1
2010 Oh SY, Chen CD, Abraham CR. Cell-type dependent modulation of Notch signaling by the amyloid precursor protein. Journal of Neurochemistry. 113: 262-74. PMID 20089128 DOI: 10.1111/j.1471-4159.2010.06603.x  1
2009 Yamin R, Zhao C, O'Connor PB, McKee AC, Abraham CR. Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide. Molecular Neurodegeneration. 4: 33. PMID 19627603 DOI: 10.1186/1750-1326-4-33  1
2008 Zerbinatti CV, Cordy JM, Chen CD, Guillily M, Suon S, Ray WJ, Seabrook GR, Abraham CR, Wolozin B. Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein. Molecular Neurodegeneration. 3: 5. PMID 18348724 DOI: 10.1186/1750-1326-3-5  1
2008 Hinman JD, Chen CD, Oh SY, Hollander W, Abraham CR. Age-dependent accumulation of ubiquitinated 2',3'-cyclic nucleotide 3'-phosphodiesterase in myelin lipid rafts. Glia. 56: 118-33. PMID 17963267 DOI: 10.1002/glia.20595  1
2008 Duce JA, Podvin S, Hollander W, Kipling D, Rosene DL, Abraham CR. Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey. Glia. 56: 106-17. PMID 17963266 DOI: 10.1002/glia.20593  1
2007 Chen CD, Podvin S, Gillespie E, Leeman SE, Abraham CR. Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Proceedings of the National Academy of Sciences of the United States of America. 104: 19796-801. PMID 18056631 DOI: 10.1073/pnas.0709805104  1
2007 Hinman JD, Abraham CR. What's behind the decline? The role of white matter in brain aging. Neurochemical Research. 32: 2023-31. PMID 17447140 DOI: 10.1007/s11064-007-9341-x  1
2007 Yamin R, Bagchi S, Hildebrant R, Scaloni A, Widom RL, Abraham CR. Acyl peptide hydrolase, a serine proteinase isolated from conditioned medium of neuroblastoma cells, degrades the amyloid-beta peptide. Journal of Neurochemistry. 100: 458-67. PMID 17241160 DOI: 10.1111/j.1471-4159.2006.04251.x  1
2006 Chen CD, Oh SY, Hinman JD, Abraham CR. Visualization of APP dimerization and APP-Notch2 heterodimerization in living cells using bimolecular fluorescence complementation. Journal of Neurochemistry. 97: 30-43. PMID 16515557 DOI: 10.1111/j.1471-4159.2006.03705.x  1
2006 Hinman JD, Peters A, Cabral H, Rosene DL, Hollander W, Rasband MN, Abraham CR. Age-related molecular reorganization at the node of Ranvier. The Journal of Comparative Neurology. 495: 351-62. PMID 16485288 DOI: 10.1002/cne.20886  1
2006 Duce JA, Hollander W, Jaffe R, Abraham CR. Activation of early components of complement targets myelin and oligodendrocytes in the aged rhesus monkey brain. Neurobiology of Aging. 27: 633-44. PMID 15992964 DOI: 10.1016/j.neurobiolaging.2005.03.027  1
2005 Oh SY, Ellenstein A, Chen CD, Hinman JD, Berg EA, Costello CE, Yamin R, Neve RL, Abraham CR. Amyloid precursor protein interacts with notch receptors. Journal of Neuroscience Research. 82: 32-42. PMID 16118793 DOI: 10.1002/jnr.20625  1
2004 Hinman JD, Duce JA, Siman RA, Hollander W, Abraham CR. Activation of calpain-1 in myelin and microglia in the white matter of the aged rhesus monkey. Journal of Neurochemistry. 89: 430-41. PMID 15056286 DOI: 10.1046/j.1471-4159.2004.02348.x  1
2003 York IA, Mo AX, Lemerise K, Zeng W, Shen Y, Abraham CR, Saric T, Goldberg AL, Rock KL. The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation. Immunity. 18: 429-40. PMID 12648459 DOI: 10.1016/S1074-7613(03)00058-X  1
2003 Sloane JA, Hinman JD, Lubonia M, Hollander W, Abraham CR. Age-dependent myelin degeneration and proteolysis of oligodendrocyte proteins is associated with the activation of calpain-1 in the rhesus monkey. Journal of Neurochemistry. 84: 157-68. PMID 12485412 DOI: 10.1046/j.1471-4159.2003.01541.x  1
2001 Abraham CR. Reactive astrocytes and alpha1-antichymotrypsin in Alzheimer's disease. Neurobiology of Aging. 22: 931-6. PMID 11755001 DOI: 10.1016/S0197-4580(01)00302-5  1
2000 Abraham CR, McGraw WT, Slot F, Yamin R. Alpha 1-antichymotrypsin inhibits A beta degradation in vitro and in vivo. Annals of the New York Academy of Sciences. 920: 245-8. PMID 11193158  1
2000 Mucke L, Yu GQ, McConlogue L, Rockenstein EM, Abraham CR, Masliah E. Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice. The American Journal of Pathology. 157: 2003-10. PMID 11106573  1
2000 Abraham CR. Amyloid beta peptide: a century of discoveries. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 7: 7-9. PMID 10842695  1
2000 Sloane JA, Hollander W, Rosene DL, Moss MB, Kemper T, Abraham CR. Astrocytic hypertrophy and altered GFAP degradation with age in subcortical white matter of the rhesus monkey. Brain Research. 862: 1-10. PMID 10799662 DOI: 10.1016/S0006-8993(00)02059-X  1
1999 Sloane JA, Hollander W, Moss MB, Rosene DL, Abraham CR. Increased microglial activation and protein nitration in white matter of the aging monkey. Neurobiology of Aging. 20: 395-405. PMID 10604432 DOI: 10.1016/S0197-4580(99)00066-4  1
1999 Yamin R, Malgeri EG, Sloane JA, McGraw WT, Abraham CR. Metalloendopeptidase EC is necessary for Alzheimer's amyloid-beta peptide degradation. The Journal of Biological Chemistry. 274: 18777-84. PMID 10373494 DOI: 10.1074/jbc.274.26.18777  1
1999 Abraham CR, Marshall DC, Tibbles HE, Otto K, Long HJ, Billingslea AM, Hastey R, Johnson R, Fine RE, Smith SJ, Simons ER, Davies TA. Platelets and DAMI megakaryocytes possess beta-secretase-like activity. The Journal of Laboratory and Clinical Medicine. 133: 507-15. PMID 10235134 DOI: 10.1016/S0022-2143(99)90028-8  1
1998 Farrer LA, Abraham CR, Haines JL, Rogaeva EA, Song Y, McGraw WT, Brindle N, Premkumar S, Scott WK, Yamaoka LH, Saunders AM, Roses AD, Auerbach SA, Sorbi S, Duara R, et al. Association between bleomycin hydrolase and Alzheimer's disease in caucasians. Annals of Neurology. 44: 808-11. PMID 9818937 DOI: 10.1002/ana.410440515  1
1998 Simons ER, Marshall DC, Long HJ, Otto K, Billingslea A, Tibbles H, Wells J, Eisenhauer P, Fine RE, Cribbs DH, Davies TA, Abraham CR. Blood brain barrier endothelial cells express candidate amyloid precursor protein-cleaving secretases. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 5: 153-62. PMID 9818052  1
1998 Marshall DC, Wyss-Coray T, Abraham CR. Induction of matrix metalloproteinase-2 in human immunodeficiency virus-1 glycoprotein 120 transgenic mouse brains. Neuroscience Letters. 254: 97-100. PMID 9779929 DOI: 10.1016/S0304-3940(98)00674-0  1
1998 Meckelein B, Marshall DC, Conn KJ, Pietropaolo M, Van Nostrand W, Abraham CR. Identification of a novel serine protease-like molecule in human brain. Brain Research. Molecular Brain Research. 55: 181-97. PMID 9582421 DOI: 10.1016/S0169-328X(97)00366-5  1
1998 Slot F, Olsen AS, Nagesh Rao P, Abraham CR. Localization of human endopeptidase EC (THOP1) to chromosome 19p13.3 Alzheimer's Reports. 1: 327-331.  1
1997 Sloane JA, Pietropaolo MF, Rosene DL, Moss MB, Peters A, Kemper T, Abraham CR. Lack of correlation between plaque burden and cognition in the aged monkey. Acta Neuropathologica. 94: 471-8. PMID 9386780 DOI: 10.1007/s004010050735  1
1997 Aleshkov S, Abraham CR, Zannis VI. Interaction of nascent ApoE2, ApoE3, and ApoE4 isoforms expressed in mammalian cells with amyloid peptide beta (1-40). Relevance to Alzheimer's disease. Biochemistry. 36: 10571-80. PMID 9265639 DOI: 10.1021/bi9626362  1
1997 Liang JS, Sloane JA, Wells JM, Abraham CR, Fine RE, Sipe JD. Evidence for local production of acute phase response apolipoprotein serum amyloid A in Alzheimer's disease brain. Neuroscience Letters. 225: 73-6. PMID 9147377 DOI: 10.1016/S0304-3940(97)00196-1  1
1997 Masliah E, Westland CE, Rockenstein EM, Abraham CR, Mallory M, Veinberg I, Sheldon E, Mucke L. Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo. Neuroscience. 78: 135-46. PMID 9135095 DOI: 10.1016/S0306-4522(96)00553-2  1
1997 Fine RE, Abraham CR. Hypothesis: β amyloid precursor protein is a key sorting and targeting receptor for neuropeptidases Amyloid. 4: 233-239.  1
1996 Kanemaru K, Meckelein B, Marshall DC, Sipe JD, Abraham CR. Synthesis and secretion of active alpha 1-antichymotrypsin by murine primary astrocytes. Neurobiology of Aging. 17: 767-71. PMID 8892350 DOI: 10.1016/0197-4580(96)00111-X  1
1996 Meckelein B, de Silva HA, Roses AD, Rao PN, Pettenati MJ, Xu PT, Hodge R, Glucksman MJ, Abraham CR. Human endopeptidase (THOP1) is localized on chromosome 19 within the linkage region for the late-onset alzheimer disease AD2 locus. Genomics. 31: 246-9. PMID 8824811 DOI: 10.1006/geno.1996.0041  1
1996 Conn KJ, Pietropaolo M, Ju ST, Abraham CR. Monoclonal antibodies against the human metalloprotease EC label neurofibrillary tangles in Alzheimer's disease brain. Journal of Neurochemistry. 66: 2011-8. PMID 8780030  1
1996 Peters A, Rosene DL, Moss MB, Kemper TL, Abraham CR, Tigges J, Albert MS. Neurobiological bases of age-related cognitive decline in the rhesus monkey. Journal of Neuropathology and Experimental Neurology. 55: 861-74. PMID 8759775  1
1996 Liang JS, Fine RE, Abraham CR, Sipe JD. The fibril forming region of the beta-amyloid precursor differs from that of the amyloid A precursor in its interaction with lipids. Biochemical and Biophysical Research Communications. 219: 962-7. PMID 8645287 DOI: 10.1006/bbrc.1996.0332  1
1996 Mucke L, Abraham CR, Masliah E. Neurotrophic and neuroprotective effects of hAPP in transgenic mice. Annals of the New York Academy of Sciences. 777: 82-8. PMID 8624131  1
1996 Chang T, Abraham CR. A novel brain cysteine protease forms an SDS stable complex with the beta-amyloid precursor protein. Annals of the New York Academy of Sciences. 777: 183-8. PMID 8624082  1
1996 Amaratunga A, Abraham CR, Edwards RB, Sandell JH, Schreiber BM, Fine RE. Apolipoprotein E is synthesized in the retina by Müller glial cells, secreted into the vitreous, and rapidly transported into the optic nerve by retinal ganglion cells. The Journal of Biological Chemistry. 271: 5628-32. PMID 8621425  1
1995 Koch D, Abraham CR. [Alzheimer's disease and the significance of amyloid-beta protein in its pathogenesis]. Harefuah. 128: 156-9. PMID 7759006  1
1995 Mucke L, Abraham CR, Ruppe MD, Rockenstein EM, Toggas SM, Mallory M, Alford M, Masliah E. Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein. The Journal of Experimental Medicine. 181: 1551-6. PMID 7699335 DOI: 10.1084/jem.181.4.1551  1
1995 Farrer LA, Abraham CR, Volicer L, Foley EJ, Kowall NW, McKee AC, Wells JM. Allele epsilon 4 of apolipoprotein E shows a dose effect on age at onset of Pick disease. Experimental Neurology. 136: 162-70. PMID 7498406 DOI: 10.1006/exnr.1995.1093  1
1995 Abraham CR. The identification of an Alzheimer's disease gene on chromosome 14 opens new avenues for Research. The views of an amyloidologist Amyloid. 2: 213-216. DOI: 10.3109/13506129509036929  1
1995 Wells JM, Amaratunga A, Mckenna DC, Abraham CR, Fine RE. Amyloid βprotein precursor and apolipoprotein e production in cultured cerebral endothelial cells isolated from brains of patients with neurodegenerative disorders at autopsy Amyloid. 2: 229-233. DOI: 10.3109/13506129508999004  1
1994 Toggas SM, Masliah E, Rockenstein EM, Rall GF, Abraham CR, Mucke L. Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature. 367: 188-93. PMID 8114918 DOI: 10.1038/367188a0  1
1994 Mucke L, Masliah E, Johnson WB, Ruppe MD, Alford M, Rockenstein EM, Forss-Petter S, Pietropaolo M, Mallory M, Abraham CR. Synaptotrophic effects of human amyloid beta protein precursors in the cortex of transgenic mice. Brain Research. 666: 151-67. PMID 7882025 DOI: 10.1016/0006-8993(94)90767-6  1
1994 Conn KJ, Papastoitsis G, Meckelein B, Abraham CR. Identification of full length βamyloid precursor protein in human neuronal and non-neuronal cell culture supernatant: A possible extracellular source for the generation of aβ Amyloid. 1: 232-239. DOI: 10.3109/13506129409146114  1
1994 Papastoitsis G, Siman R, Scott R, Abraham CR. Identification of a metalloprotease from Alzheimer's disease brain able to degrade the β-amyloid precursor protein and generate amyloidogenic fragments Biochemistry. 33: 192-199.  1
1993 Fraser PE, Nguyen JT, McLachlan DR, Abraham CR, Kirschner DA. Alpha 1-antichymotrypsin binding to Alzheimer A beta peptides is sequence specific and induces fibril disaggregation in vitro. Journal of Neurochemistry. 61: 298-305. PMID 8515277 DOI: 10.1111/j.1471-4159.1993.tb03568.x  1
1993 Razzaboni BL, Meckelein B, Abraham CR. Purification and cloning of monkey proteases involved in the processing of the beta-amyloid precursor protein. Neurobiology of Aging. 14: 677-9. PMID 8295685 DOI: 10.1016/0197-4580(93)90069-N  1
1993 Stone PJ, Campistol JM, Abraham CR, Rodgers O, Shirahama T, Skinner M. Neutrophil proteases associated with amyloid fibrils. Biochemical and Biophysical Research Communications. 197: 130-6. PMID 8250917 DOI: 10.1006/bbrc.1993.2451  1
1993 Abraham CR, Kanemaru K, Mucke L. Expression of cathepsin G-like and alpha 1-antichymotrypsin-like proteins in reactive astrocytes. Brain Research. 621: 222-32. PMID 8242336 DOI: 10.1016/0006-8993(93)90110-9  1
1993 Campbell IL, Abraham CR, Masliah E, Kemper P, Inglis JD, Oldstone MB, Mucke L. Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proceedings of the National Academy of Sciences of the United States of America. 90: 10061-5. PMID 7694279  1
1993 Morin PJ, Abraham CR, Amaratunga A, Johnson RJ, Huber G, Sandell JH, Fine RE. Amyloid precursor protein is synthesized by retinal ganglion cells, rapidly transported to the optic nerve plasma membrane and nerve terminals, and metabolized. Journal of Neurochemistry. 61: 464-73. PMID 7687653  1
1992 Abraham CR. The role of the acute-phase protein alpha 1-antichymotrypsin in brain dysfunction and injury. Research in Immunology. 143: 631-6. PMID 1455055 DOI: 10.1016/0923-2494(92)80047-O  1
1992 Razzaboni BL, Papastoitsis G, Koo EH, Abraham CR. A calcium-stimulated serine protease from monkey brain degrades the beta-amyloid precursor protein. Brain Research. 589: 207-16. PMID 1393590 DOI: 10.1016/0006-8993(92)91279-N  1
1992 Abraham CR, Razzaboni BL, Papastoitsis G, Picard E, Kanemaru K, Meckelein B, Mucke L. Purification and cloning of brain proteases capable of degrading the beta-amyloid precursor protein. Annals of the New York Academy of Sciences. 674: 174-9. PMID 1288362  1
1992 Campistol JM, Shirahama T, Abraham CR, Rodgers OG, Solé M, Cohen AS, Skinner M. Demonstration of plasma proteinase inhibitors in beta 2-microglobulin amyloid deposits. Kidney International. 42: 915-23. PMID 1280700  1
1992 Eikelenboom P, Abraham CR. Immunological fac tors in Alzheimer's diseas Research in Immunology. 143: 613-614. DOI: 10.1016/0923-2494(92)80042-J  1
1991 Abraham CR, Driscoll J, Potter H, Van Nostrand WE, Tempst P. A calcium-activated protease from Alzheimer's disease brain cleaves at the N-terminus of the amyloid beta-protein. Biochemical and Biophysical Research Communications. 174: 790-6. PMID 1993072 DOI: 10.1016/0006-291X(91)91487-W  1
1991 Richards SJ, Waters JJ, Beyreuther K, Masters CL, Wischik CM, Sparkman DR, White CL, Abraham CR, Dunnett SB. Transplants of mouse trisomy 16 hippocampus provide a model of Alzheimer's disease neuropathology. The Embo Journal. 10: 297-303. PMID 1899372  1
1991 Koo EH, Abraham CR, Potter H, Cork LC, Price DL. Developmental expression of alpha 1-antichymotrypsin in brain may be related to astrogliosis. Neurobiology of Aging. 12: 495-501. PMID 1837594 DOI: 10.1016/0197-4580(91)90079-Y  1
1991 Abraham CR, Razzaboni BL, Sisodia SS, Koo EH, Price DL, Van Nostrand WE, Papastoitsis G. Studies on the proteolytic degradation of the beta-protein precursor by proteases purified from Alzheimer's disease brain. Annals of the New York Academy of Sciences. 640: 161-5. PMID 1776735  1
1990 Abraham CR, Shirahama T, Potter H. Alpha 1-antichymotrypsin is associated solely with amyloid deposits containing the beta-protein. Amyloid and cell localization of alpha 1-antichymotrypsin. Neurobiology of Aging. 11: 123-9. PMID 2190106 DOI: 10.1016/0197-4580(90)90045-2  1
1990 Abraham CR, Bem Meir A, Tempst P. Facile and sensitive assay for monitoring proteolytic activities with defined specificities: studies on amyloid beta-protein processing in Alzheimer's disease. Peptide Research. 3: 211-5. PMID 2134064  1
1990 Abraham CR. A novel calcium-dependent protease from brain cleaves β-protein-precursor-related synthetic peptides and is inhibited by α1-antichymotrypsin and protease nexin 2 Molecular Biology and Genetics of Alzheimer's Disease: Proceedings of the International Symposium On Dementia: Molecular Biology and Genetics of Alzheimer's Disease. Ics884. 159-166.  1
1989 Pasternack JM, Abraham CR, Van Dyke BJ, Potter H, Younkin SG. Astrocytes in Alzheimer's disease gray matter express alpha 1-antichymotrypsin mRNA. The American Journal of Pathology. 135: 827-34. PMID 2817081  1
1989 Abraham CR, Selkoe DJ, Potter H, Price DL, Cork LC. Alpha 1-antichymotrypsin is present together with the beta-protein in monkey brain amyloid deposits. Neuroscience. 32: 715-20. PMID 2689908 DOI: 10.1016/0306-4522(89)90292-3  1
1989 Abraham CR. Potential roles of protease inhibitors in Alzheimer's disease. Neurobiology of Aging. 10: 463-5; discussion 47. PMID 2682323 DOI: 10.1016/0197-4580(89)90097-3  1
1989 Abraham CR, Potter H. The protease inhibitor, alpha 1-antichymotrypsin, is a component of the brain amyloid deposits in normal aging and Alzheimer's disease. Annals of Medicine. 21: 77-81. PMID 2669847 DOI: 10.3109/07853898909149188  1
1989 Abraham CR, Potter H. Alpha 1-antichymotrypsin in brain aging and disease. Progress in Clinical and Biological Research. 317: 1037-48. PMID 2513582  1
1989 Abraham CR, Potter H. Alzheimer's disease: Recent advances in understanding the brain amyloid deposits Bio/Technology. 7: 147-153.  1
1988 Abraham CR, Selkoe DJ, Potter H. Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. Cell. 52: 487-501. PMID 3257719 DOI: 10.1016/0092-8674(88)90462-X  1
1987 Duffy LK, Abraham CR, Berman-Podlisny M, Walsh RL, Selkoe DJ. HPLC analysis of proteins from Alzheimer paired helical filaments Annals of the New York Academy of Sciences. 494: 369-372.  1
1986 Selkoe DJ, Abraham CR. Isolation of paired helical filaments and amyloid fibers from human brain. Methods in Enzymology. 134: 388-404. PMID 3821571 DOI: 10.1016/0076-6879(86)34105-3  1
1986 Selkoe DJ, Abraham CR, Podlisny MB, Duffy LK. Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease. Journal of Neurochemistry. 46: 1820-34. PMID 3517233 DOI: 10.1111/j.1471-4159.1986.tb08501.x  1
1986 Kirschner DA, Abraham C, Selkoe DJ. X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation. Proceedings of the National Academy of Sciences of the United States of America. 83: 503-7. PMID 3455785  1
1985 Selkoe DJ, Abraham C, Rasool CG, McCluskey A, Kosik KS, Duffy LK. Paired helical filaments in human neurons: relationship to neurofilaments Annals of the New York Academy of Sciences. 455: 583-596. PMID 3936387 DOI: 10.1111/j.1749-6632.1985.tb50438.x  1
1985 Selkoe DJ, Abraham C, Rasool CG. Production and characterization of monoclonal antibodies to Alzheimer paired helical filaments Annals of the New York Academy of Sciences. 774-778.  1
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