Rakez Kayed - Publications

Affiliations: 
Neurology University of Texas Medical Branch, Galveston, TX 

97 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Sengupta U, Montalbano M, McAllen S, Minuesa G, Kharas M, Kayed R. Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer's disease. Acta Neuropathologica Communications. 6: 113. PMID 30367664 DOI: 10.1186/s40478-018-0615-0  0.32
2018 Ha Y, Liu W, Liu H, Zhu S, Xia F, Gerson JE, Azhar NA, Tilton RG, Motamedi M, Kayed R, Zhang W. AAV2-mediated GRP78 Transfer Alleviates Retinal Neuronal Injury by Downregulating ER Stress and Tau Oligomer Formation. Investigative Ophthalmology & Visual Science. 59: 4670-4682. PMID 30267089 DOI: 10.1167/iovs.18-24427  0.32
2018 Sengupta U, Kayed R. Amyloid oligomer interactions and polymorphisms: disease-relevant distinct assembly of α-synuclein and tau. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 30206420 DOI: 10.1038/s41386-018-0204-8  0.32
2018 Ghag G, Bhatt N, Cantu DV, Guerrero-Munoz MJ, Ellsworth A, Sengupta U, Kayed R. Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross-seeding behavior. Protein Science : a Publication of the Protein Society. PMID 30125425 DOI: 10.1002/pro.3499  0.32
2018 Sengupta U, Carretero-Murillo M, Kayed R. Preparation and Characterization of Tau Oligomer Strains. Methods in Molecular Biology (Clifton, N.J.). 1779: 113-146. PMID 29886531 DOI: 10.1007/978-1-4939-7816-8_9  0.32
2018 Gerson JE, Farmer KM, Henson N, Castillo-Carranza DL, Carretero Murillo M, Sengupta U, Barrett A, Kayed R. Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy. Molecular Neurodegeneration. 13: 13. PMID 29544548 DOI: 10.1186/s13024-018-0245-9  0.4
2018 Bittar A, Sengupta U, Kayed R. Prospects for strain-specific immunotherapy in Alzheimer's disease and tauopathies. Npj Vaccines. 3: 9. PMID 29507776 DOI: 10.1038/s41541-018-0046-8  0.32
2018 Castillo-Carranza DL, Guerrero-Muñoz MJ, Sengupta U, Gerson JE, Kayed R. α-Synuclein Oligomers Induce a Unique Toxic Tau Strain. Biological Psychiatry. PMID 29478699 DOI: 10.1016/j.biopsych.2017.12.018  0.48
2017 Castillo-Carranza DL, Nilson AN, Van Skike CE, Jahrling JB, Patel K, Garach P, Gerson JE, Sengupta U, Abisambra J, Nelson P, Troncoso J, Ungvari Z, Galvan V, Kayed R. Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer's Disease and Related Tauopathies. Aging and Disease. 8: 257-266. PMID 28580182 DOI: 10.14336/AD.2017.0112  0.4
2017 Kolarova M, Sengupta U, Bartos A, Ricny J, Kayed R. Tau Oligomers in Sera of Patients with Alzheimer's Disease and Aged Controls. Journal of Alzheimer's Disease : Jad. PMID 28453485 DOI: 10.3233/JAD-170048  0.32
2017 Sengupta U, Portelius E, Hansson O, Farmer K, Castillo-Carranza D, Woltjer R, Zetterberg H, Galasko D, Blennow K, Kayed R. Tau oligomers in cerebrospinal fluid in Alzheimer's disease. Annals of Clinical and Translational Neurology. 4: 226-235. PMID 28382304 DOI: 10.1002/acn3.382  0.32
2017 Gerson JE, Sengupta U, Kayed R. Tau Oligomers as Pathogenic Seeds: Preparation and Propagation In Vitro and In Vivo. Methods in Molecular Biology (Clifton, N.J.). 1523: 141-157. PMID 27975249 DOI: 10.1007/978-1-4939-6598-4_9  0.32
2016 Nilson AN, English KC, Gerson JE, Whittle TB, Crain CN, Xue J, Sengupta U, Castillo-Carranza DL, Zhang W, Gupta P, Kayed R. Tau Oligomers Associate with Inflammation in the Brain and Retina of Tauopathy Mice and in Neurodegenerative Diseases. Journal of Alzheimer's Disease : Jad. PMID 27716675 DOI: 10.3233/JAD-160912  0.4
2016 Gerson JE, Mudher A, Kayed R. Potential mechanisms and implications for the formation of tau oligomeric strains. Critical Reviews in Biochemistry and Molecular Biology. 51: 482-496. PMID 27650389 DOI: 10.1080/10409238.2016.1226251  0.32
2016 Sengupta U, Nilson AN, Kayed R. The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy. Ebiomedicine. 6: 42-9. PMID 27211547 DOI: 10.1016/j.ebiom.2016.03.035  0.32
2016 Gerson J, Castillo-Carranza DL, Sengupta U, Bodani R, Prough DS, DeWitt DS, Hawkins BE, Kayed R. Tau Oligomers Derived from Traumatic Brain Injury Cause Cognitive Impairment and Accelerate Onset of Pathology in Htau Mice. Journal of Neurotrauma. PMID 26729399 DOI: 10.1089/neu.2015.4262  0.4
2015 Lasagna-Reeves CA, Rousseaux MW, Guerrero-Munoz MJ, Vilanova-Velez L, Park J, See L, Jafar-Nejad P, Richman R, Orr HT, Kayed R, Zoghbi HY. Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows Spinocerebellar ataxia type 1 phenotypes. Elife. 4. PMID 26673892 DOI: 10.7554/eLife.10891  0.68
2015 Bodani RU, Sengupta U, Castillo-Carranza DL, Guerrero-Muñoz MJ, Gerson JE, Rudra J, Kayed R. Antibody against Small Aggregated Peptide Specifically Recognizes Toxic Aβ-42 Oligomers in Alzheimer's Disease. Acs Chemical Neuroscience. PMID 26448453 DOI: 10.1021/acschemneuro.5b00231  0.36
2015 Violet M, Chauderlier A, Delattre L, Tardivel M, Chouala MS, Sultan A, Marciniak E, Humez S, Binder L, Kayed R, Lefebvre B, Bonnefoy E, Buée L, Galas MC. Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo. Neurobiology of Disease. 82: 540-51. PMID 26385829 DOI: 10.1016/j.nbd.2015.09.003  0.36
2015 Deger JM, Gerson JE, Kayed R. The interrelationship of proteasome impairment and oligomeric intermediates in neurodegeneration. Aging Cell. 14: 715-24. PMID 26053162 DOI: 10.1111/acel.12359  0.32
2015 Lasagna-Reeves CA, Rousseaux MW, Guerrero-Muñoz MJ, Park J, Jafar-Nejad P, Richman R, Lu N, Sengupta U, Litvinchuk A, Orr HT, Kayed R, Zoghbi HY. A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1. Elife. 4. PMID 25988806 DOI: 10.7554/eLife.07558  0.68
2015 Castillo-Carranza DL, Guerrero-Muñoz MJ, Sengupta U, Hernandez C, Barrett AD, Dineley K, Kayed R. Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an Alzheimer's disease mouse model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 4857-68. PMID 25810517 DOI: 10.1523/JNEUROSCI.4989-14.2015  0.36
2015 Sengupta U, Guerrero-Muñoz MJ, Castillo-Carranza DL, Lasagna-Reeves CA, Gerson JE, Paulucci-Holthauzen AA, Krishnamurthy S, Farhed M, Jackson GR, Kayed R. Pathological Interface between Oligomeric Alpha-Synuclein and Tau in Synucleinopathies. Biological Psychiatry. PMID 25676491 DOI: 10.1016/j.biopsych.2014.12.019  0.36
2014 Castillo-Carranza DL, Guerrero-Muñoz MJ, Kayed R. Immunotherapy for the treatment of Alzheimer's disease: amyloid-β or tau, which is the right target? Immunotargets and Therapy. 3: 19-28. PMID 27471697 DOI: 10.2147/ITT.S40131  0.4
2014 Guerrero-Muñoz MJ, Castillo-Carranza DL, Krishnamurthy S, Paulucci-Holthauzen AA, Sengupta U, Lasagna-Reeves CA, Ahmad Y, Jackson GR, Kayed R. Amyloid-β oligomers as a template for secondary amyloidosis in Alzheimer's disease. Neurobiology of Disease. 71: 14-23. PMID 25134727 DOI: 10.1016/j.nbd.2014.08.008  0.36
2014 Gerson JE, Castillo-Carranza DL, Kayed R. Advances in therapeutics for neurodegenerative tauopathies: moving toward the specific targeting of the most toxic tau species. Acs Chemical Neuroscience. 5: 752-69. PMID 25075869 DOI: 10.1021/cn500143n  0.4
2014 Gerson JE, Sengupta U, Lasagna-Reeves CA, Guerrero-Muñoz MJ, Troncoso J, Kayed R. Characterization of tau oligomeric seeds in progressive supranuclear palsy. Acta Neuropathologica Communications. 2: 73. PMID 24927818 DOI: 10.1186/2051-5960-2-73  0.36
2014 Lasagna-Reeves CA, Sengupta U, Castillo-Carranza D, Gerson JE, Guerrero-Munoz M, Troncoso JC, Jackson GR, Kayed R. The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes. Acta Neuropathologica Communications. 2: 56. PMID 24887264 DOI: 10.1186/2051-5960-2-56  0.36
2014 Castillo-Carranza DL, Sengupta U, Guerrero-Muñoz MJ, Lasagna-Reeves CA, Gerson JE, Singh G, Estes DM, Barrett AD, Dineley KT, Jackson GR, Kayed R. Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 4260-72. PMID 24647946 DOI: 10.1523/JNEUROSCI.3192-13.2014  0.36
2014 Castillo-Carranza DL, Gerson JE, Sengupta U, Guerrero-Muñoz MJ, Lasagna-Reeves CA, Kayed R. Specific targeting of tau oligomers in Htau mice prevents cognitive impairment and tau toxicity following injection with brain-derived tau oligomeric seeds. Journal of Alzheimer's Disease : Jad. 40: S97-S111. PMID 24603946 DOI: 10.3233/JAD-132477  0.36
2014 Guerrero-Muñoz MJ, Castillo-Carranza DL, Kayed R. Therapeutic approaches against common structural features of toxic oligomers shared by multiple amyloidogenic proteins. Biochemical Pharmacology. 88: 468-78. PMID 24406245 DOI: 10.1016/j.bcp.2013.12.023  0.4
2014 Choksi DK, Roy B, Chatterjee S, Yusuff T, Bakhoum MF, Sengupta U, Ambegaokar S, Kayed R, Jackson GR. TDP-43 Phosphorylation by casein kinase Iε promotes oligomerization and enhances toxicity in vivo. Human Molecular Genetics. 23: 1025-35. PMID 24105464 DOI: 10.1093/hmg/ddt498  0.36
2013 Guerrero-Muñoz MJ, Castillo-Carranza DL, Sengupta U, White MA, Kayed R. Design of metastable β-sheet oligomers from natively unstructured peptide. Acs Chemical Neuroscience. 4: 1520-3. PMID 24106878 DOI: 10.1021/cn4001395  0.36
2013 Blair LJ, Nordhues BA, Hill SE, Scaglione KM, O'Leary JC, Fontaine SN, Breydo L, Zhang B, Li P, Wang L, Cotman C, Paulson HL, Muschol M, Uversky VN, Klengel T, ... ... Kayed R, et al. Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. The Journal of Clinical Investigation. 123: 4158-69. PMID 23999428 DOI: 10.1172/JCI69003  0.36
2013 Gerson JE, Kayed R. Formation and propagation of tau oligomeric seeds. Frontiers in Neurology. 4: 93. PMID 23882255 DOI: 10.3389/fneur.2013.00093  0.32
2013 Hawkins BE, Krishnamurthy S, Castillo-Carranza DL, Sengupta U, Prough DS, Jackson GR, DeWitt DS, Kayed R. Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies. The Journal of Biological Chemistry. 288: 17042-50. PMID 23632019 DOI: 10.1074/jbc.M113.472746  0.36
2013 Kim HY, Sengupta U, Shao P, Guerrero-Muñoz MJ, Kayed R, Bai M. Alzheimer's disease imaging with a novel Tau targeted near infrared ratiometric probe. American Journal of Nuclear Medicine and Molecular Imaging. 3: 102-17. PMID 23526074  0.48
2013 Castillo-Carranza DL, Lasagna-Reeves CA, Kayed R. Tau aggregates as immunotherapeutic targets. Frontiers in Bioscience (Scholar Edition). 5: 426-38. PMID 23277060  0.68
2013 Lasagna-Reeves CA, Clos AL, Castillo-Carranza D, Sengupta U, Guerrero-Muñoz M, Kelly B, Wagner R, Kayed R. Dual role of p53 amyloid formation in cancer; loss of function and gain of toxicity. Biochemical and Biophysical Research Communications. 430: 963-8. PMID 23261448 DOI: 10.1016/j.bbrc.2012.11.130  0.36
2013 Wu JW, Herman M, Liu L, Simoes S, Acker CM, Figueroa H, Steinberg JI, Margittai M, Kayed R, Zurzolo C, Di Paolo G, Duff KE. Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons. The Journal of Biological Chemistry. 288: 1856-70. PMID 23188818 DOI: 10.1074/jbc.M112.394528  0.36
2013 Kayed R, Lasagna-Reeves CA. Molecular mechanisms of amyloid oligomers toxicity. Journal of Alzheimer's Disease : Jad. 33: S67-78. PMID 22531422 DOI: 10.3233/JAD-2012-129001  0.68
2012 Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U, Guerrero-Munoz MJ, Kiritoshi T, Neugebauer V, Jackson GR, Kayed R. Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau. Scientific Reports. 2: 700. PMID 23050084 DOI: 10.1038/srep00700  0.36
2012 Rosenmann H, Blum D, Kayed R, Ittner LM. Tau protein: function and pathology. International Journal of Alzheimer's Disease. 2012: 707482. PMID 22928147 DOI: 10.1155/2012/707482  0.36
2012 Rasool S, Albay R, Martinez-Coria H, Breydo L, Wu J, Milton S, Misra S, Tran A, Pensalfini A, Laferla F, Kayed R, Glabe CG. Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice. Molecular Neurodegeneration. 7: 37. PMID 22866920 DOI: 10.1186/1750-1326-7-37  0.36
2012 Castillo-Carranza DL, Zhang Y, Guerrero-Muñoz MJ, Kayed R, Rincon-Limas DE, Fernandez-Funez P. Differential activation of the ER stress factor XBP1 by oligomeric assemblies. Neurochemical Research. 37: 1707-17. PMID 22528838 DOI: 10.1007/s11064-012-0780-7  0.4
2012 Clos AL, Kayed R, Lasagna-Reeves CA. Association of skin with the pathogenesis and treatment of neurodegenerative amyloidosis. Frontiers in Neurology. 3: 5. PMID 22319507 DOI: 10.3389/fneur.2012.00005  0.68
2012 Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U, Sarmiento J, Troncoso J, Jackson GR, Kayed R. Identification of oligomers at early stages of tau aggregation in Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 1946-59. PMID 22253473 DOI: 10.1096/fj.11-199851  0.36
2012 Martin ZS, Neugebauer V, Dineley KT, Kayed R, Zhang W, Reese LC, Taglialatela G. α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases. Journal of Neurochemistry. 120: 440-52. PMID 22060133 DOI: 10.1111/j.1471-4159.2011.07576.x  0.36
2011 Kayed R, Jackson GR, Estes DM, Barrett AD. Alzheimers disease: review of emerging treatment role for intravenous immunoglobulins. Journal of Central Nervous System Disease. 3: 67-73. PMID 23861639 DOI: 10.4137/JCNSD.S5018  0.36
2011 Lasagna-Reeves CA, Kayed R. Astrocytes contain amyloid-β annular protofibrils in Alzheimer's disease brains. Febs Letters. 585: 3052-7. PMID 21872592 DOI: 10.1016/j.febslet.2011.08.027  0.68
2011 Clos AL, Lasagna-Reeves CA, Kelly B, Wagner R, Wilkerson M, Jackson GR, Kayed R. Role of oligomers in the amyloidogenesis of primary cutaneous amyloidosis. Journal of the American Academy of Dermatology. 65: 1023-31. PMID 21669474 DOI: 10.1016/j.jaad.2010.09.735  0.36
2011 Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U, Clos AL, Jackson GR, Kayed R. Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice. Molecular Neurodegeneration. 6: 39. PMID 21645391 DOI: 10.1186/1750-1326-6-39  0.36
2011 Lasagna-Reeves CA, Glabe CG, Kayed R. Amyloid-β annular protofibrils evade fibrillar fate in Alzheimer disease brain. The Journal of Biological Chemistry. 286: 22122-30. PMID 21507938 DOI: 10.1074/jbc.M111.236257  0.36
2010 Kayed R, Canto I, Breydo L, Rasool S, Lukacsovich T, Wu J, Albay R, Pensalfini A, Yeung S, Head E, Marsh JL, Glabe C. Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers. Molecular Neurodegeneration. 5: 57. PMID 21144050 DOI: 10.1186/1750-1326-5-57  0.36
2010 Lasagna-Reeves CA, Castillo-Carranza DL, Guerrero-Muoz MJ, Jackson GR, Kayed R. Preparation and characterization of neurotoxic tau oligomers. Biochemistry. 49: 10039-41. PMID 21047142 DOI: 10.1021/bi1016233  0.36
2010 Lasagna-Reeves CA, Clos AL, Midoro-Hiriuti T, Goldblum RM, Jackson GR, Kayed R. Inhaled insulin forms toxic pulmonary amyloid aggregates. Endocrinology. 151: 4717-24. PMID 20685871 DOI: 10.1210/en.2010-0457  0.36
2010 Clos AL, Lasagna-Reeves CA, Wagner R, Kelly B, Jackson GR, Kayed R. Therapeutic removal of amyloid deposits in cutaneous amyloidosis by localised intra-lesional injections of anti-amyloid antibodies. Experimental Dermatology. 19: 904-11. PMID 20626464 DOI: 10.1111/j.1600-0625.2010.01121.x  0.36
2010 Dineley KT, Kayed R, Neugebauer V, Fu Y, Zhang W, Reese LC, Taglialatela G. Amyloid-beta oligomers impair fear conditioned memory in a calcineurin-dependent fashion in mice. Journal of Neuroscience Research. 88: 2923-32. PMID 20544830 DOI: 10.1002/jnr.22445  0.36
2010 Head E, Pop V, Sarsoza F, Kayed R, Beckett TL, Studzinski CM, Tomic JL, Glabe CG, Murphy MP. Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines. Journal of Alzheimer's Disease : Jad. 20: 637-46. PMID 20164551 DOI: 10.3233/JAD-2010-1397  0.36
2010 Hernandez CM, Kayed R, Zheng H, Sweatt JD, Dineley KT. Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 2442-53. PMID 20164328 DOI: 10.1523/JNEUROSCI.5038-09.2010  0.36
2010 Barrett AD, Kayed R, Jackson GR, Cunningham KA. New vaccine development for chronic brain disease. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 354. PMID 20010720 DOI: 10.1038/npp.2009.147  0.36
2010 Isas JM, Luibl V, Johnson LV, Kayed R, Wetzel R, Glabe CG, Langen R, Chen J. Soluble and mature amyloid fibrils in drusen deposits. Investigative Ophthalmology & Visual Science. 51: 1304-10. PMID 19892876 DOI: 10.1167/iovs.09-4207  0.36
2009 Mina EW, Lasagna-Reeves C, Glabe CG, Kayed R. Poloxamer 188 copolymer membrane sealant rescues toxicity of amyloid oligomers in vitro. Journal of Molecular Biology. 391: 577-85. PMID 19524592 DOI: 10.1016/j.jmb.2009.06.024  0.36
2009 Kayed R, Jackson GR. Prefilament tau species as potential targets for immunotherapy for Alzheimer disease and related disorders. Current Opinion in Immunology. 21: 359-63. PMID 19482462 DOI: 10.1016/j.coi.2009.05.001  0.36
2009 Sarsoza F, Saing T, Kayed R, Dahlin R, Dick M, Broadwater-Hollifield C, Mobley S, Lott I, Doran E, Gillen D, Anderson-Bergman C, Cribbs DH, Glabe C, Head E. A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain. Acta Neuropathologica. 118: 505-17. PMID 19360426 DOI: 10.1007/s00401-009-0530-3  0.36
2009 Kayed R, Pensalfini A, Margol L, Sokolov Y, Sarsoza F, Head E, Hall J, Glabe C. Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer. The Journal of Biological Chemistry. 284: 4230-7. PMID 19098006 DOI: 10.1074/jbc.M808591200  0.36
2008 Shin TM, Isas JM, Hsieh CL, Kayed R, Glabe CG, Langen R, Chen J. Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin. Molecular Neurodegeneration. 3: 16. PMID 18939994 DOI: 10.1186/1750-1326-3-16  0.36
2008 Reese LC, Zhang W, Dineley KT, Kayed R, Taglialatela G. Selective induction of calcineurin activity and signaling by oligomeric amyloid beta. Aging Cell. 7: 824-35. PMID 18782350 DOI: 10.1111/j.1474-9726.2008.00434.x  0.36
2008 Bacher M, Dodel R, Aljabari B, Keyvani K, Marambaud P, Kayed R, Glabe C, Goertz N, Hoppmann A, Sachser N, Klotsche J, Schnell S, Lewejohann L, Al-Abed Y. CNI-1493 inhibits Abeta production, plaque formation, and cognitive deterioration in an animal model of Alzheimer's disease. The Journal of Experimental Medicine. 205: 1593-9. PMID 18573905 DOI: 10.1084/jem.20060467  0.36
2007 Yoshiike Y, Kayed R, Milton SC, Takashima A, Glabe CG. Pore-forming proteins share structural and functional homology with amyloid oligomers. Neuromolecular Medicine. 9: 270-5. PMID 17914185 DOI: 10.1007/s12017-007-0003-6  0.36
2007 Kayed R, Head E, Sarsoza F, Saing T, Cotman CW, Necula M, Margol L, Wu J, Breydo L, Thompson JL, Rasool S, Gurlo T, Butler P, Glabe CG. Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Molecular Neurodegeneration. 2: 18. PMID 17897471 DOI: 10.1186/1750-1326-2-18  0.36
2007 Necula M, Breydo L, Milton S, Kayed R, van der Veer WE, Tone P, Glabe CG. Methylene blue inhibits amyloid Abeta oligomerization by promoting fibrillization. Biochemistry. 46: 8850-60. PMID 17595112 DOI: 10.1021/bi700411k  0.36
2007 Maloyan A, Gulick J, Glabe CG, Kayed R, Robbins J. Exercise reverses preamyloid oligomer and prolongs survival in alphaB-crystallin-based desmin-related cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America. 104: 5995-6000. PMID 17389375 DOI: 10.1073/pnas.0609202104  0.36
2007 Lin CY, Gurlo T, Kayed R, Butler AE, Haataja L, Glabe CG, Butler PC. Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice. Diabetes. 56: 1324-32. PMID 17353506 DOI: 10.2337/db06-1579  0.36
2007 Necula M, Kayed R, Milton S, Glabe CG. Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct. The Journal of Biological Chemistry. 282: 10311-24. PMID 17284452 DOI: 10.1074/jbc.M608207200  0.36
2007 Wirths O, Weis J, Kayed R, Saido TC, Bayer TA. Age-dependent axonal degeneration in an Alzheimer mouse model. Neurobiology of Aging. 28: 1689-99. PMID 16963164 DOI: 10.1016/j.neurobiolaging.2006.07.021  0.36
2006 Sokolov Y, Kozak JA, Kayed R, Chanturiya A, Glabe C, Hall JE. Soluble amyloid oligomers increase bilayer conductance by altering dielectric structure. The Journal of General Physiology. 128: 637-47. PMID 17101816 DOI: 10.1085/jgp.200609533  0.36
2006 Kayed R, Glabe CG. Conformation-dependent anti-amyloid oligomer antibodies. Methods in Enzymology. 413: 326-44. PMID 17046404 DOI: 10.1016/S0076-6879(06)13017-7  0.36
2006 Meier JJ, Kayed R, Lin CY, Gurlo T, Haataja L, Jayasinghe S, Langen R, Glabe CG, Butler PC. Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP. American Journal of Physiology. Endocrinology and Metabolism. 291: E1317-24. PMID 16849627 DOI: 10.1152/ajpendo.00082.2006  0.36
2006 Chong YH, Shin YJ, Lee EO, Kayed R, Glabe CG, Tenner AJ. ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures. The Journal of Biological Chemistry. 281: 20315-25. PMID 16714296 DOI: 10.1074/jbc.M601016200  0.36
2006 Lesné S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH. A specific amyloid-beta protein assembly in the brain impairs memory. Nature. 440: 352-7. PMID 16541076 DOI: 10.1038/nature04533  0.36
2006 Head E, Barrett EG, Murphy MP, Das P, Nistor M, Sarsoza F, Glabe CC, Kayed R, Milton S, Vasilevko V, Milgram NW, Agadjanyan MG, Cribbs DH, Cotman CW. Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta. Vaccine. 24: 2824-34. PMID 16460841 DOI: 10.1016/j.vaccine.2005.12.058  0.36
2006 Luibl V, Isas JM, Kayed R, Glabe CG, Langen R, Chen J. Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers. The Journal of Clinical Investigation. 116: 378-85. PMID 16453022 DOI: 10.1172/JCI25843  0.36
2006 Glabe CG, Kayed R. Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis. Neurology. 66: S74-8. PMID 16432151 DOI: 10.1212/01.wnl.0000192103.24796.42  0.36
2005 Zhou J, Fonseca MI, Kayed R, Hernandez I, Webster SD, Yazan O, Cribbs DH, Glabe CG, Tenner AJ. Novel Abeta peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease. Journal of Neuroinflammation. 2: 28. PMID 16332263 DOI: 10.1186/1742-2094-2-28  0.36
2005 Sanbe A, Osinska H, Villa C, Gulick J, Klevitsky R, Glabe CG, Kayed R, Robbins J. Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America. 102: 13592-7. PMID 16155124 DOI: 10.1073/pnas.0503324102  0.36
2005 Kokubo H, Kayed R, Glabe CG, Saido TC, Iwata N, Helms JB, Yamaguchi H. Oligomeric proteins ultrastructurally localize to cell processes, especially to axon terminals with higher density, but not to lipid rafts in Tg2576 mouse brain. Brain Research. 1045: 224-8. PMID 15910781 DOI: 10.1016/j.brainres.2005.03.017  0.36
2005 Demuro A, Mina E, Kayed R, Milton SC, Parker I, Glabe CG. Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers. The Journal of Biological Chemistry. 280: 17294-300. PMID 15722360 DOI: 10.1074/jbc.M500997200  0.36
2005 Kokubo H, Kayed R, Glabe CG, Yamaguchi H. Soluble Abeta oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain. Brain Research. 1031: 222-8. PMID 15649447 DOI: 10.1016/j.brainres.2004.10.041  0.36
2005 Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. The Journal of Biological Chemistry. 280: 5892-901. PMID 15590663 DOI: 10.1074/jbc.M404751200  0.36
2005 Asatryan L, Hamilton RT, Isas JM, Hwang J, Kayed R, Sevanian A. LDL phospholipid hydrolysis produces modified electronegative particles with an unfolded apoB-100 protein. Journal of Lipid Research. 46: 115-22. PMID 15489541 DOI: 10.1194/jlr.M400306-JLR200  0.36
2004 Kayed R, Sokolov Y, Edmonds B, McIntire TM, Milton SC, Hall JE, Glabe CG. Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases. The Journal of Biological Chemistry. 279: 46363-6. PMID 15385542 DOI: 10.1074/jbc.C400260200  0.36
2004 Sanbe A, Osinska H, Saffitz JE, Glabe CG, Kayed R, Maloyan A, Robbins J. Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis. Proceedings of the National Academy of Sciences of the United States of America. 101: 10132-6. PMID 15220483 DOI: 10.1073/pnas.0401900101  0.36
2003 Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron. 39: 409-21. PMID 12895417 DOI: 10.1016/S0896-6273(03)00434-3  0.36
2003 Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science (New York, N.Y.). 300: 486-9. PMID 12702875 DOI: 10.1126/science.1079469  0.36
2002 Török M, Milton S, Kayed R, Wu P, McIntire T, Glabe CG, Langen R. Structural and dynamic features of Alzheimer's Abeta peptide in amyloid fibrils studied by site-directed spin labeling. The Journal of Biological Chemistry. 277: 40810-5. PMID 12181315 DOI: 10.1074/jbc.M205659200  0.36
2002 Soreghan B, Pike C, Kayed R, Tian W, Milton S, Cotman C, Glabe CG. The influence of the carboxyl terminus of the Alzheimer Abeta peptide on its conformation, aggregation, and neurotoxic properties. Neuromolecular Medicine. 1: 81-94. PMID 12025818 DOI: 10.1385/NMM:1:1:81  0.36
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