Elizabeth Head - Publications

Sanders Brown Center on Aging University of Kentucky, Lexington, KY 
brain aging and dementia

209 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Koehl L, Harp J, Van Pelt KL, Head E, Schmitt FA. Longitudinal assessment of dementia measures in Down syndrome. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12075. PMID 33225040 DOI: 10.1002/dad2.12075  0.32
2020 Martini AC, Helman AM, McCarty KL, Lott IT, Doran E, Schmitt FA, Head E. Distribution of microglial phenotypes as a function of age and Alzheimer's disease neuropathology in the brains of people with Down syndrome. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12113. PMID 33088896 DOI: 10.1002/dad2.12113  0.36
2020 Van Pelt KL, Koehl L, Caban-Holt A, Anderson-Mooney A, Head E, Schmitt FA. Feasibility of dual-task gait to estimate Alzheimer's related cognitive decline in Down syndrome. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12092. PMID 32875058 DOI: 10.1002/dad2.12092  0.32
2020 Handen BL, Lott IT, Christian BT, Schupf N, OBryant S, Mapstone M, Fagan AM, Lee JH, Tudorascu D, Wang MC, Head E, Klunk W, Ances B, Lai F, Zaman S, et al. The Alzheimer's Biomarker Consortium-Down Syndrome: Rationale and methodology. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12065. PMID 32775597 DOI: 10.1002/dad2.12065  0.36
2020 Mapstone M, Gross TJ, Macciardi F, Cheema AK, Petersen M, Head E, Handen BL, Klunk WE, Christian BT, Silverman W, Lott IT, Schupf N. Metabolic correlates of prevalent mild cognitive impairment and Alzheimer's disease in adults with Down syndrome. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12028. PMID 32258359 DOI: 10.1002/dad2.12028  0.36
2019 Gross TJ, Doran E, Cheema AK, Head E, Lott IT, Mapstone M. Plasma Metabolites Related to Cellular Energy Metabolism Are Altered in Adults with Down Syndrome and Alzheimer's Disease. Developmental Neurobiology. PMID 31419370 DOI: 10.1002/dneu.22716  0.36
2019 Abrahamson EE, Head E, Lott IT, Handen BL, Mufson EJ, Christian BT, Klunk WE, Ikonomovic MD. Neuropathological correlates of amyloid PET imaging in Down syndrome. Developmental Neurobiology. PMID 31379087 DOI: 10.1002/dneu.22713  0.36
2019 Lott IT, Head E. Dementia in Down syndrome: unique insights for Alzheimer disease research. Nature Reviews. Neurology. PMID 30733618 DOI: 10.1038/s41582-018-0132-6  0.36
2018 Helman AM, Siever M, McCarty KL, Lott IT, Doran E, Abner EL, Schmitt FA, Head E. Microbleeds and Cerebral Amyloid Angiopathy in the Brains of People with Down Syndrome with Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 30452414 DOI: 10.3233/JAD-180589  0.36
2018 Head E, Powell DK, Schmitt FA. Metabolic and Vascular Imaging Biomarkers in Down Syndrome Provide Unique Insights Into Brain Aging and Alzheimer Disease Pathogenesis. Frontiers in Aging Neuroscience. 10: 191. PMID 29977201 DOI: 10.3389/fnagi.2018.00191  0.32
2018 Miranda AM, Herman M, Cheng R, Nahmani E, Barrett G, Micevska E, Fontaine G, Potier MC, Head E, Schmitt FA, Lott IT, Jiménez-Velázquez IZ, Antonarakis SE, Di Paolo G, Lee JH, et al. Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer's Disease. Cell Reports. 23: 2967-2975. PMID 29874583 DOI: 10.1016/j.celrep.2018.05.011  0.36
2018 Kumar S, Frost JL, Cotman CW, Head E, Palmour R, Lemere CA, Walter J. Deposition of phosphorylated amyloid-β in brains of aged nonhuman primates and canines. Brain Pathology (Zurich, Switzerland). 28: 427-430. PMID 29740941 DOI: 10.1111/bpa.12573  0.64
2017 Head E, Phelan MJ, Doran E, Kim RC, Poon WW, Schmitt FA, Lott IT. Cerebrovascular pathology in Down syndrome and Alzheimer disease. Acta Neuropathologica Communications. 5: 93. PMID 29195510 DOI: 10.1186/s40478-017-0499-4  0.36
2017 LeVine H, Spielmann HP, Matveev S, Cauvi FM, Murphy MP, Beckett TL, McCarty K, Lott IT, Doran E, Schmitt F, Head E. Down syndrome: age-dependence of PiB binding in postmortem frontal cortex across the lifespan. Neurobiology of Aging. PMID 28385551 DOI: 10.1016/j.neurobiolaging.2017.03.005  0.52
2016 Doran E, Keator D, Head E, Phelan MJ, Kim R, Totoiu M, Barrio JR, Small GW, Potkin SG, Lott IT. Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer's Disease: The Role of APP. Journal of Alzheimer's Disease : Jad. PMID 27983553 DOI: 10.3233/JAD-160836  0.36
2016 Davis PR, Giannini G, Rudolph K, Calloway N, Royer CM, Beckett TL, Murphy MP, Bresch F, Pagani D, Platt T, Wang X, Donovan AS, Sudduth TL, Lou W, Abner E, ... ... Head E, et al. Aβ vaccination in combination with behavioral enrichment in aged beagles: effects on cognition, Aβ, and microhemorrhages. Neurobiology of Aging. 49: 86-99. PMID 27776266 DOI: 10.1016/j.neurobiolaging.2016.09.007  0.52
2016 Day RJ, McCarty KL, Ockerse KE, Head E, Rohn TT. Proteolytic Cleavage of Apolipoprotein E in the Down Syndrome Brain. Aging and Disease. 7: 267-77. PMID 27330841 DOI: 10.14336/AD.2015.1020  0.36
2016 Jaeger PA, Lucin KM, Britschgi M, Vardarajan B, Huang RP, Kirby ED, Abbey R, Boeve BF, Boxer AL, Farrer LA, Finch N, Graff-Radford NR, Head E, Hoffree M, Huang R, et al. Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain. Molecular Neurodegeneration. 11: 31. PMID 27112350 DOI: 10.1186/s13024-016-0095-2  0.92
2016 Anderson-Mooney AJ, Schmitt FA, Head E, Lott IT, Heilman KM. Gait dyspraxia as a clinical marker of cognitive decline in Down syndrome: A review of theory and proposed mechanisms. Brain and Cognition. 104: 48-57. PMID 26930369 DOI: 10.1016/j.bandc.2016.02.007  0.36
2016 Head E, Lott IT, Wilcock DM, Lemere CA. Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology. Current Alzheimer Research. 13: 18-29. PMID 26651341  0.36
2016 Head E, Lott IT, Wilcock DM, Lemere CA. Aging in down syndrome and the development of Alzheimer’s disease neuropathology Current Alzheimer Research. 13: 18-29.  0.92
2015 Wilcock DM, Schmitt FA, Head E. Cerebrovascular contributions to aging and Alzheimer disease in down syndrome. Biochimica Et Biophysica Acta. PMID 26593849 DOI: 10.1016/j.bbadis.2015.11.007  0.92
2015 Wilcock DM, Hurban J, Helman AM, Sudduth TL, McCarty KL, Beckett TL, Ferrell JC, Murphy MP, Abner EL, Schmitt FA, Head E. Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease. Neurobiology of Aging. 36: 2468-74. PMID 26103884 DOI: 10.1016/j.neurobiolaging.2015.05.016  0.92
2015 Mukherjee S, Walter S, Kauwe JS, Saykin AJ, Bennett DA, Larson EB, Crane PK, Glymour MM. Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples: Mendelian randomization analyses. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26079416 DOI: 10.1016/j.jalz.2015.05.015  0.48
2015 Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, ... ... Head E, et al. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. Jama Neurology. 72: 209-16. PMID 25531812 DOI: 10.1001/jamaneurol.2014.2157  0.92
2015 Di Domenico F, Pupo G, Mancuso C, Barone E, Paolini F, Arena A, Blarzino C, Schmitt FA, Head E, Butterfield DA, Perluigi M. Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1/BVR-a system: insights for transition to Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 44: 1107-20. PMID 25391381 DOI: 10.3233/JAD-141254  0.92
2014 Rohn TT, McCarty KL, Love JE, Head E. Is Apolipoprotein E4 an Important Risk Factor for Dementia in Persons with Down Syndrome? Journal of Parkinson's Disease and Alzheimer's Disease. 1. PMID 25594074  0.36
2014 Head E, Schmitt FA. Con: are we ready to translate Alzheimer's disease-modifying therapies to people with down syndrome? Alzheimer's Research & Therapy. 6: 61. PMID 25478026 DOI: 10.1186/s13195-014-0061-6  0.92
2014 Vite CH, Head E. Aging in the canine and feline brain. The Veterinary Clinics of North America. Small Animal Practice. 44: 1113-29. PMID 25441628 DOI: 10.1016/j.cvsm.2014.07.008  0.92
2014 Izzo NJ, Xu J, Zeng C, Kirk MJ, Mozzoni K, Silky C, Rehak C, Yurko R, Look G, Rishton G, Safferstein H, Cruchaga C, Goate A, Cahill MA, Arancio O, ... ... Head E, et al. Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity. Plos One. 9: e111899. PMID 25390692 DOI: 10.1371/journal.pone.0111899  0.92
2014 Butterfield DA, Di Domenico F, Swomley AM, Head E, Perluigi M. Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain. The Biochemical Journal. 463: 177-89. PMID 25242166 DOI: 10.1042/BJ20140772  0.92
2014 Cenini G, Fiorini A, Sultana R, Perluigi M, Cai J, Klein JB, Head E, Butterfield DA. An investigation of the molecular mechanisms engaged before and after the development of Alzheimer disease neuropathology in Down syndrome: a proteomics approach. Free Radical Biology & Medicine. 76: 89-95. PMID 25151119 DOI: 10.1016/j.freeradbiomed.2014.08.006  0.92
2014 Jullienne A, Roberts JM, Pop V, Paul Murphy M, Head E, Bix GJ, Badaut J. Juvenile traumatic brain injury induces long-term perivascular matrix changes alongside amyloid-beta accumulation. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 34: 1637-45. PMID 25052558 DOI: 10.1038/jcbfm.2014.124  0.92
2014 Holler CJ, Davis PR, Beckett TL, Platt TL, Webb RL, Head E, Murphy MP. Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer's disease brain and correlates with neurofibrillary tangle pathology. Journal of Alzheimer's Disease : Jad. 42: 1221-7. PMID 25024306 DOI: 10.3233/JAD-132450  0.92
2014 Martin SB, Dowling AL, Lianekhammy J, Lott IT, Doran E, Murphy MP, Beckett TL, Schmitt FA, Head E. Synaptophysin and synaptojanin-1 in Down syndrome are differentially affected by Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 42: 767-75. PMID 24927707 DOI: 10.3233/JAD-140795  0.92
2014 Perluigi M, Pupo G, Tramutola A, Cini C, Coccia R, Barone E, Head E, Butterfield DA, Di Domenico F. Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain. Biochimica Et Biophysica Acta. 1842: 1144-53. PMID 24735980 DOI: 10.1016/j.bbadis.2014.04.007  0.92
2014 Davis PR, Head E. Prevention approaches in a preclinical canine model of Alzheimer's disease: benefits and challenges. Frontiers in Pharmacology. 5: 47. PMID 24711794 DOI: 10.3389/fphar.2014.00047  0.92
2014 Di Domenico F, Pupo G, Tramutola A, Giorgi A, Schininà ME, Coccia R, Head E, Butterfield DA, Perluigi M. Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease. Free Radical Biology & Medicine. 71: 270-80. PMID 24675226 DOI: 10.1016/j.freeradbiomed.2014.03.027  0.92
2014 Powell D, Caban-Holt A, Jicha G, Robertson W, Davis R, Gold BT, Schmitt FA, Head E. Frontal white matter integrity in adults with Down syndrome with and without dementia. Neurobiology of Aging. 35: 1562-9. PMID 24582640 DOI: 10.1016/j.neurobiolaging.2014.01.137  0.92
2014 Marchese M, Cowan D, Head E, Ma D, Karimi K, Ashthorpe V, Kapadia M, Zhao H, Davis P, Sakic B. Autoimmune manifestations in the 3xTg-AD model of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 39: 191-210. PMID 24150111 DOI: 10.3233/JAD-131490  0.92
2013 Schöniger S, Woolford L, Jutras L, Head E, de Lahunta A, Summers BA. Unusual features in four canine meningiomas. Journal of Comparative Pathology. 149: 237-41. PMID 23660088 DOI: 10.1016/j.jcpa.2013.03.003  0.92
2013 Di Domenico F, Coccia R, Cocciolo A, Murphy MP, Cenini G, Head E, Butterfield DA, Giorgi A, Schinina ME, Mancuso C, Cini C, Perluigi M. Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: redox proteomics analysis of human brain. Biochimica Et Biophysica Acta. 1832: 1249-59. PMID 23603808 DOI: 10.1016/j.bbadis.2013.04.013  0.92
2013 Roher AE, Cribbs DH, Kim RC, Maarouf CL, Whiteside CM, Kokjohn TA, Daugs ID, Head E, Liebsack C, Serrano G, Belden C, Sabbagh MN, Beach TG. Bapineuzumab alters aβ composition: implications for the amyloid cascade hypothesis and anti-amyloid immunotherapy. Plos One. 8: e59735. PMID 23555764 DOI: 10.1371/journal.pone.0059735  0.92
2013 Head E. A canine model of human aging and Alzheimer's disease. Biochimica Et Biophysica Acta. 1832: 1384-9. PMID 23528711 DOI: 10.1016/j.bbadis.2013.03.016  0.92
2013 Pop V, Sorensen DW, Kamper JE, Ajao DO, Murphy MP, Head E, Hartman RE, Badaut J. Early brain injury alters the blood-brain barrier phenotype in parallel with β-amyloid and cognitive changes in adulthood. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 33: 205-14. PMID 23149553 DOI: 10.1038/jcbfm.2012.154  0.92
2013 Kuhn DE, Nuovo GJ, Martin MM, Malana GE, Pleister AP, Jiang J, Schmittgen TD, Terry AV, Gardiner K, Head E, Feldman DS, Elton TS. Retraction notice to "Human chromosome 21-derived miRNAs are over-expressed in down syndrome brains and hearts" [Biochem. Biophys. Res. Commun. 370 (2008) 473-477] Biochemical and Biophysical Research Communications. 436: 564. DOI: 10.1016/j.bbrc.2013.06.083  0.92
2013 Pocernich C, Butterfield DA, Head E. Diet and Brain Aging: Effects on Cell and Mitochondrial Function and Structure Bioactive Food as Dietary Interventions For the Aging Population. 249-262. DOI: 10.1016/B978-0-12-397155-5.00030-1  0.92
2012 Head E, Powell D, Gold BT, Schmitt FA. Alzheimer's Disease in Down Syndrome. European Journal of Neurodegenerative Disease. 1: 353-364. PMID 25285303  0.32
2012 Head E, Murphey HL, Dowling AL, McCarty KL, Bethel SR, Nitz JA, Pleiss M, Vanrooyen J, Grossheim M, Smiley JR, Murphy MP, Beckett TL, Pagani D, Bresch F, Hendrix C. A combination cocktail improves spatial attention in a canine model of human aging and Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 32: 1029-42. PMID 22886019 DOI: 10.3233/JAD-2012-120937  0.92
2012 Head E, Silverman W, Patterson D, Lott IT. Aging and down syndrome. Current Gerontology and Geriatrics Research. 2012: 412536. PMID 22844278 DOI: 10.1155/2012/412536  0.92
2012 Tansley G, Holmes DT, Lütjohann D, Head E, Wellington CL. Sterol lipid metabolism in down syndrome revisited: down syndrome is associated with a selective reduction in serum brassicasterol levels. Current Gerontology and Geriatrics Research. 2012: 179318. PMID 22649448 DOI: 10.1155/2012/179318  0.92
2012 Holler CJ, Webb RL, Laux AL, Beckett TL, Niedowicz DM, Ahmed RR, Liu Y, Simmons CR, Dowling AL, Spinelli A, Khurgel M, Estus S, Head E, Hersh LB, Murphy MP. BACE2 expression increases in human neurodegenerative disease. The American Journal of Pathology. 180: 337-50. PMID 22074738 DOI: 10.1016/j.ajpath.2011.09.034  0.92
2012 Mariappan P, Finney SM, Head E, Somani BK, Zachou A, Smith G, Mishriki SF, N'Dow J, Grigor KM. Good quality white-light transurethral resection of bladder tumours (GQ-WLTURBT) with experienced surgeons performing complete resections and obtaining detrusor muscle reduces early recurrence in new non-muscle-invasive bladder cancer: validation across time and place and recommendation for benchmarking. Bju International. 109: 1666-73. PMID 22044434 DOI: 10.1111/j.1464-410X.2011.10571.x  0.92
2012 Saing T, Dick M, Nelson PT, Kim RC, Cribbs DH, Head E. Frontal cortex neuropathology in dementia pugilistica. Journal of Neurotrauma. 29: 1054-70. PMID 22017610 DOI: 10.1089/neu.2011.1957  0.92
2012 Cenini G, Dowling AL, Beckett TL, Barone E, Mancuso C, Murphy MP, Levine H, Lott IT, Schmitt FA, Butterfield DA, Head E. Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome. Biochimica Et Biophysica Acta. 1822: 130-8. PMID 22009041 DOI: 10.1016/j.bbadis.2011.10.001  0.92
2012 Dowling AL, Head E. Antioxidants in the canine model of human aging. Biochimica Et Biophysica Acta. 1822: 685-9. PMID 22005070 DOI: 10.1016/j.bbadis.2011.09.020  0.92
2012 Barone E, Mancuso C, Di Domenico F, Sultana R, Murphy MP, Head E, Butterfield DA. Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease. Journal of Neurochemistry. 120: 135-46. PMID 22004509 DOI: 10.1111/j.1471-4159.2011.07538.x  0.92
2012 Butterfield DA, Barone E, Di Domenico F, Cenini G, Sultana R, Murphy MP, Mancuso C, Head E. Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 15: 981-7. PMID 21767440 DOI: 10.1017/S1461145711001118  0.92
2012 Jung KM, Astarita G, Yasar S, Vasilevko V, Cribbs DH, Head E, Cotman CW, Piomelli D. An amyloid β42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease. Neurobiology of Aging. 33: 1522-32. PMID 21546126 DOI: 10.1016/j.neurobiolaging.2011.03.012  0.92
2012 Fahnestock M, Marchese M, Head E, Pop V, Michalski B, Milgram WN, Cotman CW. BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog. Neurobiology of Aging. 33: 546-54. PMID 20447733 DOI: 10.1016/j.neurobiolaging.2010.03.019  0.92
2012 Pop V, Head E, Berchtold NC, Glabe CG, Studzinski CM, Weidner AM, Murphy MP, Cotman CW. Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines. Neurobiology of Aging. 33: 108-20. PMID 20434811 DOI: 10.1016/j.neurobiolaging.2010.02.008  0.92
2011 Martin SB, Dowling AL, Head E. Therapeutic interventions targeting Beta amyloid pathogenesis in an aging dog model. Current Neuropharmacology. 9: 651-61. PMID 22654723 DOI: 10.2174/157015911798376217  0.92
2011 Astarita G, Jung KM, Vasilevko V, Dipatrizio NV, Martin SK, Cribbs DH, Head E, Cotman CW, Piomelli D. Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease. Plos One. 6: e24777. PMID 22046234 DOI: 10.1371/journal.pone.0024777  0.92
2011 Hunter MP, Nelson M, Kurzer M, Wang X, Kryscio RJ, Head E, Pinna G, O'Bryan JP. Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome. Neuroreport. 22: 767-72. PMID 21876463 DOI: 10.1097/WNR.0b013e32834ae348  0.92
2011 Martin SB, Cenini G, Barone E, Dowling AL, Mancuso C, Butterfield DA, Murphy MP, Head E. Coenzyme Q10 and cognition in atorvastatin treated dogs. Neuroscience Letters. 501: 92-5. PMID 21763754 DOI: 10.1016/j.neulet.2011.06.054  0.92
2011 Nelson PT, Head E, Schmitt FA, Davis PR, Neltner JH, Jicha GA, Abner EL, Smith CD, Van Eldik LJ, Kryscio RJ, Scheff SW. Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies. Acta Neuropathologica. 121: 571-87. PMID 21516511 DOI: 10.1007/s00401-011-0826-y  0.92
2011 Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, ... ... Head E, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nature Genetics. 43: 436-41. PMID 21460841 DOI: 10.1038/ng.801  0.92
2011 Barone E, Cenini G, Di Domenico F, Martin S, Sultana R, Mancuso C, Murphy MP, Head E, Butterfield DA. Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 63: 172-80. PMID 21193043 DOI: 10.1016/j.phrs.2010.12.007  0.92
2011 Head E, Doran E, Nistor M, Hill M, Schmitt FA, Haier RJ, Lott IT. Plasma amyloid-β as a function of age, level of intellectual disability, and presence of dementia in Down syndrome. Journal of Alzheimer's Disease : Jad. 23: 399-409. PMID 21116050 DOI: 10.3233/JAD-2010-101335  0.92
2011 Head E. Neurobiology of the aging dog. Age (Dordrecht, Netherlands). 33: 485-96. PMID 20845082 DOI: 10.1007/s11357-010-9183-3  0.92
2011 Rosario ER, Chang L, Head EH, Stanczyk FZ, Pike CJ. Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease. Neurobiology of Aging. 32: 604-13. PMID 19428144 DOI: 10.1016/j.neurobiolaging.2009.04.008  0.92
2011 Cotman CW, Head E. The canine model of human aging and disease Advances in Alzheimer's Disease. 1: 15-38. DOI: 10.3233/978-1-60750-733-8-15  0.92
2011 Murphy MP, Head E. Impact of Aging on Brain Structure and Function in Rodents and Canines Fundamental Neuropathology For Pathologists and Toxicologists: Principles and Techniques. 125-138. DOI: 10.1002/9780470939956.ch8  0.92
2010 Kayed R, Canto I, Breydo L, Rasool S, Lukacsovich T, Wu J, Albay R, Pensalfini A, Yeung S, Head E, Marsh JL, Glabe C. Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers. Molecular Neurodegeneration. 5: 57. PMID 21144050 DOI: 10.1186/1750-1326-5-57  0.92
2010 Vasilevko V, Passos GF, Quiring D, Head E, Kim RC, Fisher M, Cribbs DH. Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy. Annals of the New York Academy of Sciences. 1207: 58-70. PMID 20955427 DOI: 10.1111/j.1749-6632.2010.05786.x  0.92
2010 Murphy MP, Morales J, Beckett TL, Astarita G, Piomelli D, Weidner A, Studzinski CM, Dowling AL, Wang X, Levine H, Kryscio RJ, Lin Y, Barrett E, Head E. Changes in cognition and amyloid-β processing with long term cholesterol reduction using atorvastatin in aged dogs. Journal of Alzheimer's Disease : Jad. 22: 135-50. PMID 20847439 DOI: 10.3233/JAD-2010-100639  0.92
2010 Astarita G, Jung KM, Berchtold NC, Nguyen VQ, Gillen DL, Head E, Cotman CW, Piomelli D. Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease. Plos One. 5: e12538. PMID 20838618 DOI: 10.1371/journal.pone.0012538  0.92
2010 Pop V, Head E, Hill MA, Gillen D, Berchtold NC, Muggenburg BA, Milgram NW, Murphy MP, Cotman CW. Synergistic effects of long-term antioxidant diet and behavioral enrichment on beta-amyloid load and non-amyloidogenic processing in aged canines. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9831-9. PMID 20660265 DOI: 10.1523/JNEUROSCI.6194-09.2010  0.92
2010 Coskun PE, Wyrembak J, Derbereva O, Melkonian G, Doran E, Lott IT, Head E, Cotman CW, Wallace DC. Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia. Journal of Alzheimer's Disease : Jad. 20: S293-310. PMID 20463402 DOI: 10.3233/JAD-2010-100351  0.92
2010 Vasilevko V, Pop V, Kim HJ, Saing T, Glabe CC, Milton S, Barrett EG, Cotman CW, Cribbs DH, Head E. Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta. Neurobiology of Disease. 39: 301-10. PMID 20451612 DOI: 10.1016/j.nbd.2010.04.014  0.92
2010 Head E, Pop V, Sarsoza F, Kayed R, Beckett TL, Studzinski CM, Tomic JL, Glabe CG, Murphy MP. Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines. Journal of Alzheimer's Disease : Jad. 20: 637-46. PMID 20164551 DOI: 10.3233/JAD-2010-1397  0.92
2010 Armstrong RA, Ellis W, Hamilton RL, Mackenzie IR, Hedreen J, Gearing M, Montine T, Vonsattel JP, Head E, Lieberman AP, Cairns NJ. Neuropathological heterogeneity in frontotemporal lobar degeneration with TDP-43 proteinopathy: a quantitative study of 94 cases using principal components analysis. Journal of Neural Transmission (Vienna, Austria : 1996). 117: 227-39. PMID 20012109 DOI: 10.1007/s00702-009-0350-6  0.92
2010 Kuhn DE, Nuovo GJ, Terry AV, Martin MM, Malana GE, Sansom SE, Pleister AP, Beck WD, Head E, Feldman DS, Elton TS. Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains. The Journal of Biological Chemistry. 285: 1529-43. PMID 19897480 DOI: 10.1074/jbc.M109.033407  0.92
2010 Eriksen JL, Murphy MP, Head E. Pharmacological Models for Preclinical Testing: From Mouse to Dog to Nonhuman Primates Bace: Lead Target For Orchestrated Therapy of Alzheimer's Disease. 159-175. DOI: 10.1002/9780470594087.ch7  0.92
2009 Kumasaka DK, Galvan V, Head E, Rohn TT. Caspase cleavage of the amyloid precursor protein is prevented after overexpression of bcl-2 in a triple transgenic mouse model of Alzheimer's disease. International Journal of Physiology, Pathophysiology and Pharmacology. 1: 48-56. PMID 20411026  0.36
2009 Joseph J, Cole G, Head E, Ingram D. Nutrition, brain aging, and neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12795-801. PMID 19828791 DOI: 10.1523/JNEUROSCI.3520-09.2009  0.92
2009 Christie LA, Opii WO, Head E, Araujo JA, de Rivera C, Milgram NW, Cotman CW. Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles. Experimental Gerontology. 44: 752-9. PMID 19735717 DOI: 10.1016/j.exger.2009.08.012  0.92
2009 Christie LA, Opii WO, Head E. Strategies for improving cognition with aging: insights from a longitudinal study of antioxidant and behavioral enrichment in canines. Age (Dordrecht, Netherlands). 31: 211-20. PMID 19714491 DOI: 10.1007/s11357-008-9063-2  0.92
2009 Head E, Nukala VN, Fenoglio KA, Muggenburg BA, Cotman CW, Sullivan PG. Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging. Experimental Neurology. 220: 171-6. PMID 19703441 DOI: 10.1016/j.expneurol.2009.08.014  0.92
2009 Tomic JL, Pensalfini A, Head E, Glabe CG. Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction. Neurobiology of Disease. 35: 352-8. PMID 19523517 DOI: 10.1016/j.nbd.2009.05.024  0.92
2009 Sarsoza F, Saing T, Kayed R, Dahlin R, Dick M, Broadwater-Hollifield C, Mobley S, Lott I, Doran E, Gillen D, Anderson-Bergman C, Cribbs DH, Glabe C, Head E. A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain. Acta Neuropathologica. 118: 505-17. PMID 19360426 DOI: 10.1007/s00401-009-0530-3  0.92
2009 Vasilevko V, Head E. Immunotherapy in a natural model of Abeta pathogenesis: the aging beagle. Cns & Neurological Disorders Drug Targets. 8: 98-113. PMID 19355931 DOI: 10.2174/187152709787847333  0.92
2009 Berlau DJ, Corrada MM, Head E, Kawas CH. APOE epsilon2 is associated with intact cognition but increased Alzheimer pathology in the oldest old. Neurology. 72: 829-34. PMID 19255410 DOI: 10.1212/01.wnl.0000343853.00346.a4  0.92
2009 Kayed R, Pensalfini A, Margol L, Sokolov Y, Sarsoza F, Head E, Hall J, Glabe C. Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer. The Journal of Biological Chemistry. 284: 4230-7. PMID 19098006 DOI: 10.1074/jbc.M808591200  0.92
2009 Rohn TT, Head E. Caspases as therapeutic targets in Alzheimer's disease: is it time to "cut" to the chase? International Journal of Clinical and Experimental Pathology. 2: 108-18. PMID 19079646  0.92
2009 Head E. Oxidative damage and cognitive dysfunction: antioxidant treatments to promote healthy brain aging. Neurochemical Research. 34: 670-8. PMID 18683046 DOI: 10.1007/s11064-008-9808-4  0.92
2009 Head E, Corrada MM, Kahle-Wrobleski K, Kim RC, Sarsoza F, Goodus M, Kawas CH. Synaptic proteins, neuropathology and cognitive status in the oldest-old. Neurobiology of Aging. 30: 1125-34. PMID 18006193 DOI: 10.1016/j.neurobiolaging.2007.10.001  0.92
2009 Head E. Degeneration in Canine Brain Aging From Development to Degeneration and Regeneration of the Nervous System. DOI: 10.1093/acprof:oso/9780195369007.003.0009  0.92
2009 Kumasaka DK, Galvan V, Head E, Rohn TT. Caspase cleavage of the amyloid precursor protein is prevented after overexpression of bcl-2 in a triple transgenic mouse model of Alzheimer's disease International Journal of Physiology, Pathophysiology and Pharmacology. 1: 48-56.  0.92
2008 Rohn TT, Head E. Caspase activation in Alzheimer's disease: early to rise and late to bed. Reviews in the Neurosciences. 19: 383-93. PMID 19317178  0.92
2008 Cotman CW, Head E. The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches. Journal of Alzheimer's Disease : Jad. 15: 685-707. PMID 19096165  0.92
2008 Berchtold NC, Cribbs DH, Coleman PD, Rogers J, Head E, Kim R, Beach T, Miller C, Troncoso J, Trojanowski JQ, Zielke HR, Cotman CW. Gene expression changes in the course of normal brain aging are sexually dimorphic. Proceedings of the National Academy of Sciences of the United States of America. 105: 15605-10. PMID 18832152 DOI: 10.1073/pnas.0806883105  0.92
2008 Christie LA, Saunders RC, Kowalska DM, MacKay WA, Head E, Cotman CW. Rhinal and dorsolateral prefrontal cortex lesions produce selective impairments in object and spatial learning and memory in canines. The Journal of Comparative Neurology. 511: 257-70. PMID 18792072 DOI: 10.1002/cne.21821  0.92
2008 Movsesyan N, Ghochikyan A, Mkrtichyan M, Petrushina I, Davtyan H, Olkhanud PB, Head E, Biragyn A, Cribbs DH, Agadjanyan MG. Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine - a novel immunotherapeutic strategy. Plos One. 3: e2124. PMID 18461171 DOI: 10.1371/journal.pone.0002124  0.92
2008 Kuhn DE, Nuovo GJ, Martin MM, Malana GE, Pleister AP, Jiang J, Schmittgen TD, Terry AV, Gardiner K, Head E, Feldman DS, Elton TS. Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts. Biochemical and Biophysical Research Communications. 370: 473-7. PMID 18387358 DOI: 10.1016/j.bbrc.2008.03.120  0.92
2008 Head E, Pop V, Vasilevko V, Hill M, Saing T, Sarsoza F, Nistor M, Christie LA, Milton S, Glabe C, Barrett E, Cribbs D. A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 3555-66. PMID 18385314 DOI: 10.1523/JNEUROSCI.0208-08.2008  0.92
2008 Rohn TT, Vyas V, Hernandez-Estrada T, Nichol KE, Christie LA, Head E. Lack of pathology in a triple transgenic mouse model of Alzheimer's disease after overexpression of the anti-apoptotic protein Bcl-2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 3051-9. PMID 18354008 DOI: 10.1523/JNEUROSCI.5620-07.2008  0.92
2008 Shen W, Liu K, Tian C, Yang L, Li X, Ren J, Packer L, Head E, Sharman E, Liu J. Protective effects of R-alpha-lipoic acid and acetyl-L-carnitine in MIN6 and isolated rat islet cells chronically exposed to oleic acid. Journal of Cellular Biochemistry. 104: 1232-43. PMID 18260126 DOI: 10.1002/jcb.21701  0.92
2008 Head E, Rofina J, Zicker S. Oxidative stress, aging, and central nervous system disease in the canine model of human brain aging. The Veterinary Clinics of North America. Small Animal Practice. 38: 167-78, vi. PMID 18249248 DOI: 10.1016/j.cvsm.2007.10.002  0.92
2008 Haier RJ, Head K, Head E, Lott IT. Neuroimaging of individuals with Down's syndrome at-risk for dementia: evidence for possible compensatory events. Neuroimage. 39: 1324-32. PMID 18006337 DOI: 10.1016/j.neuroimage.2007.09.064  0.92
2008 Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW. Region specific neuron loss in the aged canine hippocampus is reduced by enrichment. Neurobiology of Aging. 29: 39-50. PMID 17092609 DOI: 10.1016/j.neurobiolaging.2006.09.018  0.92
2008 Opii WO, Joshi G, Head E, Milgram NW, Muggenburg BA, Klein JB, Pierce WM, Cotman CW, Butterfield DA. Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease. Neurobiology of Aging. 29: 51-70. PMID 17055614 DOI: 10.1016/j.neurobiolaging.2006.09.012  0.92
2007 Petrushina I, Ghochikyan A, Mktrichyan M, Mamikonyan G, Movsesyan N, Davtyan H, Patel A, Head E, Cribbs DH, Agadjanyan MG. Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 12721-31. PMID 18003852 DOI: 10.1523/JNEUROSCI.3201-07.2007  0.92
2007 Kayed R, Head E, Sarsoza F, Saing T, Cotman CW, Necula M, Margol L, Wu J, Breydo L, Thompson JL, Rasool S, Gurlo T, Butler P, Glabe CG. Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Molecular Neurodegeneration. 2: 18. PMID 17897471 DOI: 10.1186/1750-1326-2-18  0.92
2007 Head E. Combining an antioxidant-fortified diet with behavioral enrichment leads to cognitive improvement and reduced brain pathology in aging canines: strategies for healthy aging. Annals of the New York Academy of Sciences. 1114: 398-406. PMID 17717087 DOI: 10.1196/annals.1396.004  0.92
2007 Berlau DJ, Kahle-Wrobleski K, Head E, Goodus M, Kim R, Kawas C. Dissociation of neuropathologic findings and cognition: case report of an apolipoprotein E epsilon2/epsilon2 genotype. Archives of Neurology. 64: 1193-6. PMID 17698712 DOI: 10.1001/archneur.64.8.1193  0.92
2007 Gunn-Moore D, Moffat K, Christie LA, Head E. Cognitive dysfunction and the neurobiology of ageing in cats. The Journal of Small Animal Practice. 48: 546-53. PMID 17617164 DOI: 10.1111/j.1748-5827.2007.00386.x  0.92
2007 Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW. Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function. Neurobiology of Learning and Memory. 88: 249-59. PMID 17587610 DOI: 10.1016/j.nlm.2007.05.001  0.92
2007 Head E, Lott IT, Patterson D, Doran E, Haier RJ. Possible compensatory events in adult Down syndrome brain prior to the development of Alzheimer disease neuropathology: targets for nonpharmacological intervention. Journal of Alzheimer's Disease : Jad. 11: 61-76. PMID 17361036  0.92
2007 Nistor M, Don M, Parekh M, Sarsoza F, Goodus M, Lopez GE, Kawas C, Leverenz J, Doran E, Lott IT, Hill M, Head E. Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain. Neurobiology of Aging. 28: 1493-506. PMID 16904243 DOI: 10.1016/j.neurobiolaging.2006.06.023  0.92
2007 Mukherjee J, Head E, Pichika R, Easwaramoorthy B, Collins D, Chen I, Wang CS, Saigal N, Trinidad P, Kim K, Nguyen VL. Radiotracers for a multi-target approach to the diagnosis of Alzheimer's disease Journal of Labelled Compounds and Radiopharmaceuticals. 50: 375-379. DOI: 10.1002/jlcr.1266  0.92
2006 Lott IT, Head E, Doran E, Busciglio J. Beta-amyloid, oxidative stress and down syndrome. Current Alzheimer Research. 3: 521-8. PMID 17168651 DOI: 10.2174/156720506779025305  0.92
2006 Milgram NW, Siwak-Tapp CT, Araujo J, Head E. Neuroprotective effects of cognitive enrichment. Ageing Research Reviews. 5: 354-69. PMID 16949888 DOI: 10.1016/j.arr.2006.04.004  0.92
2006 Head E, Starr A, Kim RC, Parachikova A, Lopez GE, Dick M, Cribbs DH. Relapsing polychondritis with features of dementia with Lewy bodies. Acta Neuropathologica. 112: 217-25. PMID 16832629 DOI: 10.1007/s00401-006-0098-0  0.92
2006 Studzinski CM, Christie LA, Araujo JA, Burnham WM, Head E, Cotman CW, Milgram NW. Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia. Neurobiology of Learning and Memory. 86: 197-204. PMID 16616528 DOI: 10.1016/j.nlm.2006.02.005  0.92
2006 Gunn-Moore DA, McVee J, Bradshaw JM, Pearson GR, Head E, Gunn-Moore FJ. Ageing changes in cat brains demonstrated by beta-amyloid and AT8-immunoreactive phosphorylated tau deposits. Journal of Feline Medicine and Surgery. 8: 234-42. PMID 16603401 DOI: 10.1016/j.jfms.2006.01.003  0.92
2006 Mouser PE, Head E, Ha KH, Rohn TT. Caspase-mediated cleavage of glial fibrillary acidic protein within degenerating astrocytes of the Alzheimer's disease brain. The American Journal of Pathology. 168: 936-46. PMID 16507909 DOI: 10.2353/ajpath.2006.050798  0.92
2006 Head E, Barrett EG, Murphy MP, Das P, Nistor M, Sarsoza F, Glabe CC, Kayed R, Milton S, Vasilevko V, Milgram NW, Agadjanyan MG, Cribbs DH, Cotman CW. Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta. Vaccine. 24: 2824-34. PMID 16460841 DOI: 10.1016/j.vaccine.2005.12.058  0.92
2006 Tapp PD, Head K, Head E, Milgram NW, Muggenburg BA, Su MY. Application of an automated voxel-based morphometry technique to assess regional gray and white matter brain atrophy in a canine model of aging. Neuroimage. 29: 234-44. PMID 16275022 DOI: 10.1016/j.neuroimage.2005.07.043  0.92
2006 Chubb C, Inagaki Y, Sheu P, Cummings B, Wasserman A, Head E, Cotman C. BioVision: an application for the automated image analysis of histological sections. Neurobiology of Aging. 27: 1462-76. PMID 16271803 DOI: 10.1016/j.neurobiolaging.2005.08.023  0.92
2005 Araujo JA, Studzinski CM, Head E, Cotman CW, Milgram NW. Assessment of nutritional interventions for modification of age-associated cognitive decline using a canine model of human aging. Age (Dordrecht, Netherlands). 27: 27-37. PMID 23598601 DOI: 10.1007/s11357-005-4001-z  0.92
2005 Roudebush P, Zicker SC, Cotman CW, Milgram NW, Muggenburg BA, Head E. Nutritional management of brain aging in dogs. Journal of the American Veterinary Medical Association. 227: 722-8. PMID 16178393 DOI: 10.2460/javma.2005.227.722  0.92
2005 Newman J, Rissman RA, Sarsoza F, Kim RC, Dick M, Bennett DA, Cotman CW, Rohn TT, Head E. Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology. Acta Neuropathologica. 110: 135-44. PMID 15986225 DOI: 10.1007/s00401-005-1027-3  0.92
2005 Siwak CT, Tapp PD, Head E, Zicker SC, Murphey HL, Muggenburg BA, Ikeda-Douglas CJ, Cotman CW, Milgram NW. Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 29: 461-9. PMID 15795055 DOI: 10.1016/j.pnpbp.2004.12.011  0.92
2005 Nelson L, Johnson JK, Freedman M, Lott I, Groot J, Chang M, Milgram NW, Head E. Learning and memory as a function of age in Down syndrome: a study using animal-based tasks. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 29: 443-53. PMID 15795053 DOI: 10.1016/j.pnpbp.2004.12.009  0.92
2005 Tapp PD, Chu Y, Araujo JA, Chiou JY, Head E, Milgram NW, Su MY. Effects of scopolamine challenge on regional cerebral blood volume. A pharmacological model to validate the use of contrast enhanced magnetic resonance imaging to assess cerebral blood volume in a canine model of aging. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 29: 399-406. PMID 15795048 DOI: 10.1016/j.pnpbp.2004.12.006  0.92
2005 Su MY, Tapp PD, Vu L, Chen YF, Chu Y, Muggenburg B, Chiou JY, Chen C, Wang J, Bracco C, Head E. A longitudinal study of brain morphometrics using serial magnetic resonance imaging analysis in a canine model of aging. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 29: 389-97. PMID 15795047 DOI: 10.1016/j.pnpbp.2004.12.005  0.92
2005 Christie LA, Studzinski CM, Araujo JA, Leung CS, Ikeda-Douglas CJ, Head E, Cotman CW, Milgram NW. A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 29: 361-9. PMID 15795044 DOI: 10.1016/j.pnpbp.2004.12.002  0.92
2005 Helguera P, Pelsman A, Pigino G, Wolvetang E, Head E, Busciglio J. ets-2 promotes the activation of a mitochondrial death pathway in Down's syndrome neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2295-303. PMID 15745955 DOI: 10.1523/JNEUROSCI.5107-04.2005  0.92
2005 Head E, Moffat K, Das P, Sarsoza F, Poon WW, Landsberg G, Cotman CW, Murphy MP. Beta-amyloid deposition and tau phosphorylation in clinically characterized aged cats. Neurobiology of Aging. 26: 749-63. PMID 15708450 DOI: 10.1016/j.neurobiolaging.2004.06.015  0.92
2005 Thomas SN, Soreghan BA, Nistor M, Sarsoza F, Head E, Yang AJ. Reduced neuronal expression of synaptic transmission modulator HNK-1/neural cell adhesion molecule as a potential consequence of amyloid beta-mediated oxidative stress: a proteomic approach. Journal of Neurochemistry. 92: 705-17. PMID 15686472 DOI: 10.1111/j.1471-4159.2004.02892.x  0.92
2005 Lott IT, Head E. Alzheimer disease and Down syndrome: factors in pathogenesis. Neurobiology of Aging. 26: 383-9. PMID 15639317 DOI: 10.1016/j.neurobiolaging.2004.08.005  0.92
2005 Milgram NW, Head E, Zicker SC, Ikeda-Douglas CJ, Murphey H, Muggenburg B, Siwak C, Tapp D, Cotman CW. Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study. Neurobiology of Aging. 26: 77-90. PMID 15585348 DOI: 10.1016/j.neurobiolaging.2004.02.014  0.92
2005 Head E, Cotman CW, Zicker SC, Milgram NW. The use of dietary antioxidants and mitochondrial co-factors to promote successful aging Current Topics in Nutraceutical Research. 3: 85-94.  0.92
2004 Liu J, Head E, Kuratsune H, Cotman CW, Ames BN. Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats. Annals of the New York Academy of Sciences. 1033: 117-31. PMID 15591009 DOI: 10.1196/annals.1320.011  0.92
2004 Tapp PD, Siwak CT, Gao FQ, Chiou JY, Black SE, Head E, Muggenburg BA, Cotman CW, Milgram NW, Su MY. Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 8205-13. PMID 15385603 DOI: 10.1523/JNEUROSCI.1339-04.2004  0.92
2004 Tapp PD, Siwak CT, Head E, Cotman CW, Murphey H, Muggenburg BA, Ikeda-Douglas C, Milgram NW. Concept abstraction in the aging dog: development of a protocol using successive discrimination and size concept tasks. Behavioural Brain Research. 153: 199-210. PMID 15219721 DOI: 10.1016/j.bbr.2003.12.003  0.92
2004 Johnson JK, Vogt BA, Kim R, Cotman CW, Head E. Isolated executive impairment and associated frontal neuropathology. Dementia and Geriatric Cognitive Disorders. 17: 360-7. PMID 15178954 DOI: 10.1159/000078183  0.92
2004 Milgram NW, Head E, Zicker SC, Ikeda-Douglas C, Murphey H, Muggenberg BA, Siwak CT, Tapp PD, Lowry SR, Cotman CW. Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs. Experimental Gerontology. 39: 753-65. PMID 15130670 DOI: 10.1016/j.exger.2004.01.007  0.92
2004 Head E, Zicker SC. Nutraceuticals, aging, and cognitive dysfunction. The Veterinary Clinics of North America. Small Animal Practice. 34: 217-28. PMID 15032129  0.56
2004 Head E, Lott IT. Down syndrome and beta-amyloid deposition. Current Opinion in Neurology. 17: 95-100. PMID 15021233  0.36
2003 Haier RJ, Alkire MT, White NS, Uncapher MR, Head E, Lott IT, Cotman CW. Temporal cortex hypermetabolism in Down syndrome prior to the onset of dementia. Neurology. 61: 1673-9. PMID 14694028  0.92
2003 Zhao M, Su J, Head E, Cotman CW. Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease. Neurobiology of Disease. 14: 391-403. PMID 14678756 DOI: 10.1016/j.nbd.2003.07.006  0.92
2003 Ghochikyan A, Vasilevko V, Petrushina I, Movsesyan N, Babikyan D, Tian W, Sadzikava N, Ross TM, Head E, Cribbs DH, Agadjanyan MG. Generation and characterization of the humoral immune response to DNA immunization with a chimeric beta-amyloid-interleukin-4 minigene. European Journal of Immunology. 33: 3232-41. PMID 14635031 DOI: 10.1002/eji.200324000  0.92
2003 Nippak PM, Chan AD, Campbell Z, Muggenburg B, Head E, Ikeda-Douglas CJ, Murphey H, Cotman CW, Milgram NW. Response latency in Canis familiaris: mental ability or mental strategy? Behavioral Neuroscience. 117: 1066-75. PMID 14570555 DOI: 10.1037/0735-7044.117.5.1066  0.92
2003 Head E, Lott IT, Hof PR, Bouras C, Su JH, Kim R, Haier R, Cotman CW. Parallel compensatory and pathological events associated with tau pathology in middle aged individuals with Down syndrome. Journal of Neuropathology and Experimental Neurology. 62: 917-26. PMID 14533781  0.64
2003 Siwak CT, Tapp PD, Zicker SC, Murphey HL, Muggenburg BA, Head E, Cotman CW, Milgram NW. Locomotor activity rhythms in dogs vary with age and cognitive status. Behavioral Neuroscience. 117: 813-24. PMID 12931965 DOI: 10.1037/0735-7044.117.4.813  0.92
2003 Bi X, Head E, Cotman CW, Lynch G. Spatial patterns of mammalian brain aging: distribution of cathepsin D-immunoreactive cell bodies and dystrophic dendrites in aging dogs resembles that in Alzheimer's disease. The Journal of Comparative Neurology. 464: 371-81. PMID 12900930 DOI: 10.1002/cne.10795  0.92
2003 Torp R, Ottersen OP, Cotman CW, Head E. Identification of neuronal plasma membrane microdomains that colocalize beta-amyloid and presenilin: implications for beta-amyloid precursor protein processing. Neuroscience. 120: 291-300. PMID 12890502 DOI: 10.1016/S0306-4522(03)00320-8  0.92
2003 Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science (New York, N.Y.). 300: 486-9. PMID 12702875 DOI: 10.1126/science.1079469  0.92
2003 Tapp PD, Siwak CT, Estrada J, Head E, Muggenburg BA, Cotman CW, Milgram NW. Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging. Learning & Memory (Cold Spring Harbor, N.Y.). 10: 64-73. PMID 12551965 DOI: 10.1101/lm.54403  0.92
2002 Rohn TT, Rissman RA, Head E, Cotman CW. Caspase Activation in the Alzheimer's Disease Brain: Tortuous and Torturous. Drug News & Perspectives. 15: 549-557. PMID 12677194 DOI: 10.1358/dnp.2002.15.9.740233  0.92
2002 Rohn TT, Rissman RA, Davis MC, Kim YE, Cotman CW, Head E. Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain. Neurobiology of Disease. 11: 341-54. PMID 12505426 DOI: 10.1006/nbdi.2002.0549  0.92
2002 Aliev G, Seyidova D, Neal ML, Shi J, Lamb BT, Siedlak SL, Vinters HV, Head E, Perry G, Lamanna JC, Friedland RP, Cotman CW. Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice. Annals of the New York Academy of Sciences. 977: 45-64. PMID 12480733  0.92
2002 Milgram NW, Head E, Muggenburg B, Holowachuk D, Murphey H, Estrada J, Ikeda-Douglas CJ, Zicker SC, Cotman CW. Landmark discrimination learning in the dog: effects of age, an antioxidant fortified food, and cognitive strategy. Neuroscience and Biobehavioral Reviews. 26: 679-95. PMID 12479842 DOI: 10.1016/S0149-7634(02)00039-8  0.92
2002 Cotman CW, Head E, Muggenburg BA, Zicker S, Milgram NW. Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction. Neurobiology of Aging. 23: 809-18. PMID 12392784 DOI: 10.1016/S0197-4580(02)00073-8  0.92
2002 Milgram NW, Zicker SC, Head E, Muggenburg BA, Murphey H, Ikeda-Douglas CJ, Cotman CW. Dietary enrichment counteracts age-associated cognitive dysfunction in canines. Neurobiology of Aging. 23: 737-45. PMID 12392778 DOI: 10.1016/S0197-4580(02)00020-9  0.92
2002 Head E, Lott IT, Cribbs DH, Cotman CW, Rohn TT. Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome. Neuroscience Letters. 330: 99-103. PMID 12213643 DOI: 10.1016/S0304-3940(02)00705-X  0.92
2002 Head E, Liu J, Hagen TM, Muggenburg BA, Milgram NW, Ames BN, Cotman CW. Oxidative damage increases with age in a canine model of human brain aging. Journal of Neurochemistry. 82: 375-81. PMID 12124438 DOI: 10.1046/j.1471-4159.2002.00969.x  0.92
2002 Su JH, Kesslak JP, Head E, Cotman CW. Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain. Acta Neuropathologica. 104: 1-6. PMID 12070657 DOI: 10.1007/s00401-002-0548-2  0.92
2002 Chan AD, Nippak PM, Murphey H, Ikeda-Douglas CJ, Muggenburg B, Head E, Cotman CW, Milgram NW. Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility. Behavioral Neuroscience. 116: 443-54. PMID 12049325 DOI: 10.1037/0735-7044.116.3.443  0.92
2002 Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, Cotman CW, Ames BN. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Proceedings of the National Academy of Sciences of the United States of America. 99: 2356-61. PMID 11854529 DOI: 10.1073/pnas.261709299  0.92
2001 Rohn TT, Head E, Nesse WH, Cotman CW, Cribbs DH. Activation of caspase-8 in the Alzheimer's disease brain. Neurobiology of Disease. 8: 1006-16. PMID 11741396 DOI: 10.1006/nbdi.2001.0449  0.92
2001 Head E, Garzon-Rodriguez W, Johnson JK, Lott IT, Cotman CW, Glabe C. Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndrome. Neurobiology of Disease. 8: 792-806. PMID 11592849 DOI: 10.1006/nbdi.2001.0431  0.92
2001 Lott IT, Head E. Down syndrome and Alzheimer's disease: a link between development and aging. Mental Retardation and Developmental Disabilities Research Reviews. 7: 172-8. PMID 11553933 DOI: 10.1002/mrdd.1025  0.36
2001 Head E, Azizeh BY, Lott IT, Tenner AJ, Cotman CW, Cribbs DH. Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down Syndrome. Neurobiology of Disease. 8: 252-65. PMID 11300721 DOI: 10.1006/nbdi.2000.0380  0.92
2001 Rohn TT, Head E, Su JH, Anderson AJ, Bahr BA, Cotman CW, Cribbs DH. Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease. The American Journal of Pathology. 158: 189-98. PMID 11141492 DOI: 10.1016/S0002-9440(10)63957-0  0.92
2000 Torp R, Head E, Cotman CW. Ultrastructural analyses of beta-amyloid in the aged dog brain: neuronal beta-amyloid is localized to the plasma membrane. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 24: 801-10. PMID 11191714 DOI: 10.1016/S0278-5846(00)00107-X  0.92
2000 Head E, Thornton PL, Tong L, Cotman CW. Initiation and propagation of molecular cascades in human brain aging: insight from the canine model to promote successful aging. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 24: 777-86. PMID 11191712 DOI: 10.1016/S0278-5846(00)00105-6  0.92
2000 Callahan H, Ikeda-Douglas C, Head E, Cotman CW, Milgram NW. Development of a protocol for studying object recognition memory in the dog. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 24: 693-707. PMID 11191709 DOI: 10.1016/S0278-5846(00)00102-0  0.92
2000 Head E, Cotman CW, Milgram NW. Canine cognition, aging and neuropathology. Introduction. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 24: 671-3. PMID 11191707 DOI: 10.1016/S0278-5846(00)00100-7  0.92
2000 Johnson JK, Head E, Kim R, Starr A, Cotman CW. Topography, histology, and seminology in dementia Archives of Neurology. 57: 899-900. PMID 10867791  0.92
2000 Head E, McCleary R, Hahn FF, Milgram NW, Cotman CW. Region-specific age at onset of beta-amyloid in dogs. Neurobiology of Aging. 21: 89-96. PMID 10794853 DOI: 10.1016/S0197-4580(00)00093-2  0.92
2000 Azizeh BY, Head E, Ibrahim MA, Torp R, Tenner AJ, Kim RC, Lott IT, Cotman CW. Molecular dating of senile plaques in the brains of individuals with Down syndrome and in aged dogs. Experimental Neurology. 163: 111-22. PMID 10785449 DOI: 10.1006/exnr.2000.7359  0.92
2000 Torp R, Head E, Milgram NW, Hahn F, Ottersen OP, Cotman CW. Ultrastructural evidence of fibrillar beta-amyloid associated with neuronal membranes in behaviorally characterized aged dog brains. Neuroscience. 96: 495-506. PMID 10717430 DOI: 10.1016/S0306-4522(99)00568-0  0.92
2000 Adams B, Chan A, Callahan H, Siwak C, Tapp D, Ikeda-Douglas C, Atkinson P, Head E, Cotman CW, Milgram NW. Use of a delayed non-matching to position task to model age-dependent cognitive decline in the dog. Behavioural Brain Research. 108: 47-56. PMID 10680756 DOI: 10.1016/S0166-4328(99)00132-1  0.92
1999 Johnson JK, Head E, Kim R, Starr A, Cotman CW. Clinical and pathological evidence for a frontal variant of Alzheimer disease. Archives of Neurology. 56: 1233-9. PMID 10520939 DOI: 10.1001/archneur.56.10.1233  0.92
1999 Fonseca MI, Head E, Velazquez P, Cotman CW, Tenner AJ. The presence of isoaspartic acid in beta-amyloid plaques indicates plaque age. Experimental Neurology. 157: 277-88. PMID 10364440 DOI: 10.1006/exnr.1999.7058  0.92
1999 Milgram NW, Adams B, Callahan H, Head E, Mackay B, Thirlwell C, Cotman CW. Landmark discrimination learning in the dog. Learning & Memory (Cold Spring Harbor, N.Y.). 6: 54-61. PMID 10355524  0.92
1998 Su MY, Head E, Brooks WM, Wang Z, Muggenburg BA, Adam GE, Sutherland R, Cotman CW, Nalcioglu O. Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging. Neurobiology of Aging. 19: 479-85. PMID 9880050 DOI: 10.1016/S0197-4580(98)00081-5  0.92
1998 Head E, Callahan H, Muggenburg BA, Cotman CW, Milgram NW. Visual-discrimination learning ability and beta-amyloid accumulation in the dog. Neurobiology of Aging. 19: 415-25. PMID 9880044 DOI: 10.1016/S0197-4580(98)00084-0  0.92
1998 Ikeda-Douglas CJ, Head E, Holsinger RM, Tremblay L, Racine R, Milgram NW. Selective loss of early suppression in the dentate gyrus precedes kainic acid induced electrographic seizures. Epilepsy Research. 31: 143-52. PMID 9714506 DOI: 10.1016/S0920-1211(98)00028-X  0.92
1998 Ruehl WW, Neilson J, Hart B, Head E, Bruyette DS, Cummings BJ. Therapeutic actions of L-deprenyl in dogs: a model of human brain aging. Advances in Pharmacology (San Diego, Calif.). 42: 316-9. PMID 9327904  0.52
1997 Cammisuli S, Murphy MP, Ikeda-Douglas CJ, Balkissoon V, Holsinger RM, Head E, Michael M, Racine RJ, Milgram NW. Effects of extended electrical kindling on exploratory behavior and spatial learning. Behavioural Brain Research. 89: 179-90. PMID 9475625 DOI: 10.1016/S0166-4328(97)00059-4  0.92
1997 Satou T, Cummings BJ, Head E, Nielson KA, Hahn FF, Milgram NW, Velazquez P, Cribbs DH, Tenner AJ, Cotman CW. The progression of beta-amyloid deposition in the frontal cortex of the aged canine. Brain Research. 774: 35-43. PMID 9452189 DOI: 10.1016/S0006-8993(97)81684-8  0.92
1997 Head E, Callahan H, Cummings BJ, Cotman CW, Ruehl WW, Muggenberg BA, Milgram NW. Open field activity and human interaction as a function of age and breed in dogs. Physiology & Behavior. 62: 963-71. PMID 9333188 DOI: 10.1016/S0031-9384(97)00198-4  0.92
1996 Cummings BJ, Satou T, Head E, Milgram NW, Cole GM, Savage MJ, Podlisny MB, Selkoe DJ, Siman R, Greenberg BD, Cotman CW. Diffuse plaques contain C-terminal A beta 42 and not A beta 40: evidence from cats and dogs. Neurobiology of Aging. 17: 653-9. PMID 8832640 DOI: 10.1016/0197-4580(96)00062-0  0.92
1996 Head E, Hartley J, Kameka AM, Mehta R, Ivy GO, Ruehl WW, Milgram NW. The effects of L-deprenyl on spatial short term memory in young and aged dogs. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 20: 515-30. PMID 8771606 DOI: 10.1016/0278-5846(96)00014-0  0.92
1996 Cummings BJ, Head E, Ruehl W, Milgram NW, Cotman CW. The canine as an animal model of human aging and dementia. Neurobiology of Aging. 17: 259-68. PMID 8744407 DOI: 10.1016/0197-4580(95)02060-8  0.92
1996 Cummings BJ, Head E, Afagh AJ, Milgram NW, Cotman CW. Beta-amyloid accumulation correlates with cognitive dysfunction in the aged canine. Neurobiology of Learning and Memory. 66: 11-23. PMID 8661247 DOI: 10.1006/nlme.1996.0039  0.92
1995 Ruehl WW, Bruyette DS, DePaoli A, Cotman CW, Head E, Milgram NW, Cummings BJ. Canine cognitive dysfunction as a model for human age-related cognitive decline, dementia and Alzheimer's disease: clinical presentation, cognitive testing, pathology and response to 1-deprenyl therapy. Progress in Brain Research. 106: 217-25. PMID 8584657  0.92
1995 Head E, Mehta R, Hartley J, Kameka M, Cummings BJ, Cotman CW, Ruehl WW, Milgram NW. Spatial learning and memory as a function of age in the dog. Behavioral Neuroscience. 109: 851-8. PMID 8554710  0.92
1995 Milgram NW, Michael M, Cammisuli S, Head E, Ferbinteanu J, Reid C, Murphy MP, Racine R. Development of spontaneous seizures over extended electrical kindling. II. Persistence of dentate inhibitory suppression. Brain Research. 670: 112-20. PMID 7719710 DOI: 10.1016/0006-8993(94)01277-O  0.92
1995 Milgram NW, Ivy GO, Murphy MP, Head E, Wu PH, Ruehl WW, Yu PH, Durden DA, Davis BA, Boulton AA. Effects of chronic oral administration of L-deprenyl in the dog. Pharmacology, Biochemistry, and Behavior. 51: 421-8. PMID 7667363 DOI: 10.1016/0091-3057(94)00417-H  0.92
1994 Milgram NW, Head E, Weiner E, Thomas E. Cognitive functions and aging in the dog: acquisition of nonspatial visual tasks. Behavioral Neuroscience. 108: 57-68. PMID 8192851 DOI: 10.1037//0735-7044.108.1.57  0.92
1994 Carrillo MC, Ivy GO, Milgram NW, Head E, Wu P, Kitani K. (-)Deprenyl increases activities of superoxide dismutase (SOD) in striatum of dog brain. Life Sciences. 54: 1483-9. PMID 8190023 DOI: 10.1016/0024-3205(94)90015-9  0.92
1994 Ivy GO, Rick JT, Murphy MP, Head E, Reid C, Milgram NW. Effects of L-deprenyl on manifestations of aging in the rat and dog. Annals of the New York Academy of Sciences. 717: 45-59. PMID 8030851 DOI: 10.1111/j.1749-6632.1994.tb12072.x  0.92
1993 Milgram NW, Ivy GO, Head E, Murphy MP, Wu PH, Ruehl WW, Yu PH, Durden DA, Davis BA, Paterson IA. The effect of L-deprenyl on behavior, cognitive function, and biogenic amines in the dog. Neurochemical Research. 18: 1211-9. PMID 8272186 DOI: 10.1007/BF00975038  0.92
1992 Head E, Milgram NW. Changes in spontaneous behavior in the dog following oral administration of L-deprenyl. Pharmacology, Biochemistry, and Behavior. 43: 749-57. PMID 1448469 DOI: 10.1016/0091-3057(92)90404-4  0.92
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