| Year |
Citation |
Score |
| 2025 |
Valdes P, Caldwell AB, Liu Q, Fitzgerald MQ, Ramachandran S, Karch CM, Galasko DR, Yuan SH, Wagner SL, Subramaniam S. Integrative multiomics reveals common endotypes across PSEN1, PSEN2, and APP mutations in familial Alzheimer's disease. Alzheimer's Research & Therapy. 17: 5. PMID 39754192 DOI: 10.1186/s13195-024-01659-6 |
0.364 |
|
| 2024 |
Tu JC, Millar PR, Strain JF, Eck A, Adeyemo B, Snyder AZ, Daniels A, Karch C, Huey ED, McDade E, Day GS, Yakushev I, Hassenstab J, Morris J, Llibre-Guerra JJ, et al. Increasing hub disruption parallels dementia severity in autosomal dominant Alzheimer's disease. Network Neuroscience (Cambridge, Mass.). 8: 1265-1290. PMID 39735502 DOI: 10.1162/netn_a_00395 |
0.401 |
|
| 2024 |
Vermunt L, Sutphen CL, Dicks E, de Leeuw DM, Allegri RF, Berman SB, Cash DM, Chhatwal JP, Cruchaga C, Day GS, Ewers M, Farlow MR, Fox NC, Ghetti B, Graff-Radford NR, ... ... Karch CM, et al. Axonal damage and inflammation response are biological correlates of decline in small-world values: a cohort study in autosomal dominant Alzheimer's disease. Brain Communications. 6: fcae357. PMID 39440304 DOI: 10.1093/braincomms/fcae357 |
0.531 |
|
| 2024 |
Daniels AJ, McDade E, Llibre-Guerra JJ, Xiong C, Perrin RJ, Ibanez L, Supnet-Bell C, Cruchaga C, Goate A, Renton AE, Benzinger TLS, Gordon BA, Hassenstab J, Karch C, Popp B, et al. 15 Years of Longitudinal Genetic, Clinical, Cognitive, Imaging, and Biochemical Measures in DIAN. Medrxiv : the Preprint Server For Health Sciences. PMID 39148846 DOI: 10.1101/2024.08.08.24311689 |
0.655 |
|
| 2024 |
McDade E, Liu H, Bui Q, Hassenstab J, Gordon B, Benzinger T, Shen Y, Timsina J, Wang L, Sung YJ, Karch C, Renton A, Daniels A, Morris J, Xiong C, et al. Ubiquitin-Proteasome System in the Different Stages of Dominantly Inherited Alzheimer's Disease. Research Square. PMID 39108475 DOI: 10.21203/rs.3.rs-4202125/v1 |
0.579 |
|
| 2024 |
Sun Z, Kwon JS, Ren Y, Chen S, Walker CK, Lu X, Cates K, Karahan H, Sviben S, Fitzpatrick JAJ, Valdez C, Houlden H, Karch CM, Bateman RJ, Sato C, et al. Modeling late-onset Alzheimer's disease neuropathology via direct neuronal reprogramming. Science (New York, N.Y.). 385: adl2992. PMID 39088624 DOI: 10.1126/science.adl2992 |
0.334 |
|
| 2024 |
Hernández D, Morgan Schlicht S, Elli Clarke J, Daniszewski M, Karch CM, Goate AM, Pébay A. Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the PSEN1 H163R mutation. Stem Cell Research. 79: 103495. PMID 39079290 DOI: 10.1016/j.scr.2024.103495 |
0.438 |
|
| 2024 |
Schultz SA, Liu L, Schultz AP, Fitzpatrick CD, Levin R, Bellier JP, Shirzadi Z, Joseph-Mathurin N, Chen CD, Benzinger TLS, Day GS, Farlow MR, Gordon BA, Hassenstab JJ, Jack CR, ... ... Karch CM, et al. γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS). The Lancet. Neurology. PMID 39074479 DOI: 10.1016/S1474-4422(24)00236-9 |
0.41 |
|
| 2024 |
Theofilas P, Wang C, Butler D, Morales DO, Petersen C, Ambrose A, Chin B, Yang T, Khan S, Ng R, Kayed R, Karch CM, Miller BL, Gestwicki JE, Gan L, et al. iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death. Molecular and Cellular Neurosciences. 103954. PMID 39032719 DOI: 10.1016/j.mcn.2024.103954 |
0.376 |
|
| 2024 |
Kloske CM, Belloy ME, Blue EE, Bowman GR, Carrillo MC, Chen X, Chiba-Falek O, Davis AA, Paolo GD, Garretti F, Gate D, Golden LR, Heinecke JW, Herz J, Huang Y, ... ... Karch CM, et al. Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 39031528 DOI: 10.1002/alz.13877 |
0.554 |
|
| 2024 |
Fernandez MV, Liu M, Beric A, Johnson M, Cetin A, Patel M, Budde J, Kohlfeld P, Bergmann K, Lowery J, Flynn A, Brock W, Sanchez Montejo B, Gentsch J, Sykora N, ... ... Karch C, et al. Genetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center. Scientific Data. 11: 768. PMID 38997326 DOI: 10.1038/s41597-024-03485-9 |
0.56 |
|
| 2024 |
D'Brant L, Rugenstein N, Na SK, Miller MJ, Czajka TF, Trudeau N, Fitz E, Tomaszek L, Fisher ES, Mash E, Joy S, Lotz S, Borden S, Stevens K, Goderie SK, ... ... Karch CM, et al. Fully Human Bifunctional Intrabodies Achieve Graded Reduction of Intracellular Tau and Rescue Survival of Mutation iPSC-derived Neurons. Biorxiv : the Preprint Server For Biology. PMID 38854137 DOI: 10.1101/2024.05.28.596248 |
0.357 |
|
| 2024 |
Eteleeb AM, Novotny BC, Tarraga CS, Sohn C, Dhungel E, Brase L, Nallapu A, Buss J, Farias F, Bergmann K, Bradley J, Norton J, Gentsch J, Wang F, Davis AA, ... ... Karch CM, et al. Brain high-throughput multi-omics data reveal molecular heterogeneity in Alzheimer's disease. Plos Biology. 22: e3002607. PMID 38687811 DOI: 10.1371/journal.pbio.3002607 |
0.418 |
|
| 2024 |
Levin J, Baiardi S, Quadalti C, Rossi M, Mammana A, Vöglein J, Bernhardt A, Perrin RJ, Jucker M, Preische O, Hofmann A, Höglinger GU, Cairns NJ, Franklin EE, Chrem P, ... ... Karch CM, et al. α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 38666355 DOI: 10.1002/alz.13818 |
0.694 |
|
| 2024 |
Murakami R, Watanabe H, Hashimoto H, Kashiwagi-Hakozaki M, Hashimoto T, Karch CM, Iwatsubo T, Okano H. Inhibitory roles of Christchurch astrocytes in curbing tau propagation using human pluripotent stem cell-derived models. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 38649269 DOI: 10.1523/JNEUROSCI.1709-23.2024 |
0.314 |
|
| 2024 |
Wisch JK, McKay NS, Boerwinkle AH, Kennedy J, Flores S, Handen BL, Christian BT, Head E, Mapstone M, Rafii MS, O'Bryant SE, Price JC, Laymon CM, Krinsky-McHale SJ, Lai F, ... ... Karch CM, et al. Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study. The Lancet. Neurology. 23: 500-510. PMID 38631766 DOI: 10.1016/S1474-4422(24)00084-X |
0.606 |
|
| 2024 |
Sexton CE, Bitan G, Bowles KR, Brys M, Buée L, Maina MB, Clelland CD, Cohen AD, Crary JF, Dage JL, Diaz K, Frost B, Gan L, Goate AM, Golbe LI, ... ... Karch CM, et al. Novel avenues of tau research. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 38170841 DOI: 10.1002/alz.13533 |
0.362 |
|
| 2023 |
Millar PR, Gordon BA, Wisch JK, Schultz SA, Benzinger TL, Cruchaga C, Hassenstab JJ, Ibanez L, Karch C, Llibre-Guerra JJ, Morris JC, Perrin RJ, Supnet-Bell C, Xiong C, Allegri RF, et al. Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease. Molecular Neurodegeneration. 18: 98. PMID 38111006 DOI: 10.1186/s13024-023-00688-3 |
0.525 |
|
| 2023 |
Tu JC, Millar PR, Strain JF, Eck A, Adeyemo B, Daniels A, Karch C, Huey ED, McDade E, Day GS, Yakushev I, Hassenstab J, Morris J, Llibre-Guerra JJ, Ibanez L, et al. Increasing hub disruption parallels dementia severity in autosomal dominant Alzheimer disease. Biorxiv : the Preprint Server For Biology. PMID 37961586 DOI: 10.1101/2023.10.29.564633 |
0.371 |
|
| 2023 |
Shirzadi Z, Schultz SA, Yau WW, Joseph-Mathurin N, Fitzpatrick CD, Levin R, Kantarci K, Preboske GM, Jack CR, Farlow MR, Hassenstab J, Jucker M, Morris JC, Xiong C, Karch CM, et al. Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease. Jama Neurology. PMID 37843849 DOI: 10.1001/jamaneurol.2023.3618 |
0.663 |
|
| 2023 |
Johnson ECB, Bian S, Haque RU, Carter EK, Watson CM, Gordon BA, Ping L, Duong DM, Epstein MP, McDade E, Barthélemy NR, Karch CM, Xiong C, Cruchaga C, Perrin RJ, et al. Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease. Nature Medicine. PMID 37550416 DOI: 10.1038/s41591-023-02476-4 |
0.624 |
|
| 2023 |
Bertucci T, Bowles KR, Lotz S, Qi L, Stevens K, Goderie SK, Borden S, Oja LM, Lane K, Lotz R, Lotz H, Chowdhury R, Joy S, Arduini BL, Butler DC, ... ... Karch CM, et al. Improved Protocol for Reproducible Human Cortical Organoids Reveals Early Alterations in Metabolism with Mutations. Biorxiv : the Preprint Server For Biology. PMID 37503195 DOI: 10.1101/2023.07.11.548571 |
0.409 |
|
| 2023 |
McKay NS, Gordon BA, Hornbeck RC, Dincer A, Flores S, Keefe SJ, Joseph-Mathurin N, Jack CR, Koeppe R, Millar PR, Ances BM, Chen CD, Daniels A, Hobbs DA, Jackson K, ... ... Karch C, et al. Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN). Nature Neuroscience. PMID 37429916 DOI: 10.1038/s41593-023-01359-8 |
0.574 |
|
| 2023 |
Sung YJ, Yang C, Norton J, Johnson M, Fagan A, Bateman RJ, Perrin RJ, Morris JC, Farlow MR, Chhatwal JP, Schofield PR, Chui H, Wang F, Novotny B, Eteleeb A, ... Karch C, et al. Proteomics of brain, CSF, and plasma identifies molecular signatures for distinguishing sporadic and genetic Alzheimer's disease. Science Translational Medicine. 15: eabq5923. PMID 37406134 DOI: 10.1126/scitranslmed.abq5923 |
0.779 |
|
| 2023 |
Sun Z, Kwon JS, Ren Y, Chen S, Cates K, Lu X, Walker CK, Karahan H, Sviben S, Fitzpatrick JAJ, Valdez C, Houlden H, Karch CM, Bateman RJ, Sato C, et al. Endogenous recapitulation of Alzheimer's disease neuropathology through human 3D direct neuronal reprogramming. Biorxiv : the Preprint Server For Biology. PMID 37292658 DOI: 10.1101/2023.05.24.542155 |
0.325 |
|
| 2023 |
Schultz SA, Shirzadi Z, Schultz AP, Liu L, Fitzpatrick CD, McDade E, Barthelemy NR, Renton A, Esposito B, Joseph-Mathurin N, Cruchaga C, Chen CD, Goate A, Allegri RF, Benzinger TLS, ... ... Karch CM, et al. Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer's disease. Aging Cell. e13871. PMID 37291760 DOI: 10.1111/acel.13871 |
0.644 |
|
| 2023 |
Grizzanti J, Moritz WR, Pait MC, Stanley M, Kaye SD, Carroll CM, Constantino NJ, Deitelzweig LJ, Snipes JA, Kellar D, Caesar EE, Pettit-Mee RJ, Day SM, Sens JP, Nicol NI, ... ... Karch CM, et al. KATP channels are necessary for glucose dependent increases in amyloid-beta and Alzheimer's-related pathology. Jci Insight. PMID 37129980 DOI: 10.1172/jci.insight.162454 |
0.31 |
|
| 2023 |
Filipello F, You SF, Mirfakhar FS, Mahali S, Bollman B, Acquarone M, Korvatska O, Marsh JA, Sivaraman A, Martinez R, Cantoni C, De Feo L, Ghezzi L, Minaya MA, Renganathan A, ... ... Karch CM, et al. Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation. Acta Neuropathologica. 145: 749-772. PMID 37115208 DOI: 10.1007/s00401-023-02568-y |
0.301 |
|
| 2023 |
Ali M, Archer DB, Gorijala P, Western D, Timsina J, Fernández MV, Wang TC, Satizabal CL, Yang Q, Beiser AS, Wang R, Chen G, Gordon B, Benzinger TLS, Xiong C, ... ... Karch CM, et al. Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease. Acta Neuropathologica Communications. 11: 68. PMID 37101235 DOI: 10.1186/s40478-023-01563-4 |
0.625 |
|
| 2023 |
Brase L, You SF, D'Oliveira Albanus R, Del-Aguila JL, Dai Y, Novotny BC, Soriano-Tarraga C, Dykstra T, Fernandez MV, Budde JP, Bergmann K, Morris JC, Bateman RJ, Perrin RJ, McDade E, ... ... Karch CM, et al. Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers. Nature Communications. 14: 2314. PMID 37085492 DOI: 10.1038/s41467-023-37437-5 |
0.754 |
|
| 2023 |
Minaya MA, Mahali S, Iyer AK, Eteleeb AM, Martinez R, Huang G, Budde J, Temple S, Nana AL, Seeley WW, Spina S, Grinberg LT, Harari O, Karch CM. Conserved gene signatures shared among mutations reveal defects in calcium signaling. Frontiers in Molecular Biosciences. 10: 1051494. PMID 36845551 DOI: 10.3389/fmolb.2023.1051494 |
0.67 |
|
| 2023 |
Horie K, Li Y, Barthélemy NR, Gordon BA, Hassenstab J, Benzinger TLS, Fagan AM, Morris JC, Karch CM, Xiong C, Allegri R, Mendez PC, Ikeuchi T, Kasuga K, Noble J, et al. Change in cerebrospinal fluid tau microtubule binding region detects symptom onset, cognitive decline, tangles, and atrophy in Dominantly Inherited Alzheimer's Disease. Annals of Neurology. PMID 36843330 DOI: 10.1002/ana.26620 |
0.396 |
|
| 2023 |
You SF, Brase L, Filipello F, Iyer AK, Del-Aguila J, He J, D'Oliveira Albanus R, Budde J, Norton J, Gentsch J, Dräger NM, Sattler SM, Kampmann M, Piccio L, Morris JC, ... ... Karch CM, et al. MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state. Medrxiv : the Preprint Server For Health Sciences. PMID 36798226 DOI: 10.1101/2023.02.06.23285545 |
0.742 |
|
| 2023 |
Wheelock MD, Strain JF, Mansfield P, Tu JC, Tanenbaum A, Preische O, Chhatwal JP, Cash DM, Cruchaga C, Fagan AM, Fox NC, Graff-Radford NR, Hassenstab J, Jack CR, Karch CM, et al. Brain network decoupling with increased serum neurofilament and reduced cognitive function in Alzheimer's disease. Brain : a Journal of Neurology. PMID 36625756 DOI: 10.1093/brain/awac498 |
0.455 |
|
| 2022 |
Chatterjee P, Vermunt L, Gordon BA, Pedrini S, Boonkamp L, Armstrong NJ, Xiong C, Singh AK, Li Y, Sohrabi HR, Taddei K, Molloy M, Benzinger TLS, Morris JC, Karch C, et al. Plasma glial fibrillary acidic protein in autosomal dominant Alzheimer's disease: Associations with Aβ-PET, neurodegeneration, and cognition. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 36576155 DOI: 10.1002/alz.12879 |
0.669 |
|
| 2022 |
Mahali S, Martinez R, King M, Verbeck A, Harari O, Benitez BA, Horie K, Sato C, Temple S, Karch CM. Defective proteostasis in induced pluripotent stem cell models of frontotemporal lobar degeneration. Translational Psychiatry. 12: 508. PMID 36494352 DOI: 10.1038/s41398-022-02274-5 |
0.694 |
|
| 2022 |
Horie K, Barthélemy NR, Spina S, VandeVrede L, He Y, Paterson RW, Wright BA, Day GS, Davis AA, Karch CM, Seeley WW, Perrin RJ, Koppisetti RK, Shaikh F, Lago AL, et al. CSF tau microtubule-binding region identifies pathological changes in primary tauopathies. Nature Medicine. PMID 36424467 DOI: 10.1038/s41591-022-02075-9 |
0.375 |
|
| 2022 |
Drieu A, Du S, Storck SE, Rustenhoven J, Papadopoulos Z, Dykstra T, Zhong F, Kim K, Blackburn S, Mamuladze T, Harari O, Karch CM, Bateman RJ, Perrin R, Farlow M, et al. Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid. Nature. PMID 36352225 DOI: 10.1038/s41586-022-05397-3 |
0.683 |
|
| 2022 |
Novotny BC, Fernandez MV, Wang C, Budde JP, Bergmann K, Eteleeb AM, Bradley J, Webster C, Ebl C, Norton J, Gentsch J, Dube U, Wang F, Morris JC, Bateman RJ, ... ... Karch CM, et al. Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brains. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 36251323 DOI: 10.1002/alz.12800 |
0.804 |
|
| 2022 |
Li F, Eteleeb AM, Buchser W, Sohn C, Wang G, Xiong C, Payne PR, McDade E, Karch CM, Harari O, Cruchaga C. Weakly activated core neuroinflammation pathways were identified as a central signaling mechanism contributing to the chronic neurodegeneration in Alzheimer's disease. Frontiers in Aging Neuroscience. 14: 935279. PMID 36238934 DOI: 10.3389/fnagi.2022.935279 |
0.765 |
|
| 2022 |
Takada LT, Aláez-Verson C, Burgute BD, Nitrini R, Sosa AL, Castilhos RM, Chaves MF, Longoria EM, Carrillo-Sánchez K, Brucki SMD, Flores-Lagunes LL, Molina C, Olivares MJ, Ziegemeier E, Petranek J, ... ... Karch CM, et al. Discovery and validation of dominantly inherited Alzheimer's disease mutations in populations from Latin America. Alzheimer's Research & Therapy. 14: 108. PMID 35932032 DOI: 10.1186/s13195-022-01052-1 |
0.652 |
|
| 2022 |
Tcw J, Qian L, Pipalia NH, Chao MJ, Liang SA, Shi Y, Jain BR, Bertelsen SE, Kapoor M, Marcora E, Sikora E, Andrews EJ, Martini AC, Karch CM, Head E, et al. Cholesterol and matrisome pathways dysregulated in astrocytes and microglia. Cell. 185: 2213-2233.e25. PMID 35750033 DOI: 10.1016/j.cell.2022.05.017 |
0.489 |
|
| 2022 |
Vöglein J, Franzmeier N, Morris JC, Dieterich M, McDade E, Simons M, Preische O, Hofmann A, Hassenstab J, Benzinger TL, Fagan A, Noble JM, Berman SB, Graff-Radford NR, Ghetti B, ... ... Karch CM, et al. Patterns and implications of neurological examination findings in autosomal dominant Alzheimer disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 35609137 DOI: 10.1002/alz.12684 |
0.512 |
|
| 2022 |
Luckett PH, Chen C, Gordon BA, Wisch J, Berman SB, Chhatwal JP, Cruchaga C, Fagan AM, Farlow MR, Fox NC, Jucker M, Levin J, Masters CL, Mori H, Noble JM, ... ... Karch CM, et al. Biomarker clustering in autosomal dominant Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 35362200 DOI: 10.1002/alz.12661 |
0.58 |
|
| 2022 |
Strain JF, Barthelemy N, Horie K, Gordon BA, Kilgore C, Aschenbrenner A, Cruchaga C, Xiong C, Joseph-Mathurin N, Hassenstab J, Fagan AM, Li Y, Karch CM, Perrin RJ, Berman SB, et al. CSF Tau phosphorylation at Thr205 is associated with loss of white matter integrity in autosomal dominant Alzheimer disease. Neurobiology of Disease. 168: 105714. PMID 35358703 DOI: 10.1016/j.nbd.2022.105714 |
0.588 |
|
| 2022 |
Morenas-Rodríguez E, Li Y, Nuscher B, Franzmeier N, Xiong C, Suárez-Calvet M, Fagan AM, Schultz S, Gordon BA, Benzinger TLS, Hassenstab J, McDade E, Feederle R, Karch CM, Schlepckow K, et al. Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study. The Lancet. Neurology. 21: 329-341. PMID 35305339 DOI: 10.1016/S1474-4422(22)00027-8 |
0.458 |
|
| 2022 |
Liu L, Lauro BM, He A, Lee H, Bhattarai S, Wolfe MS, Bennett DA, Karch CM, Young-Pearse T, Selkoe DJ. Identification of the Aβ37/42 peptide ratio in CSF as an improved Aβ biomarker for Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 35278341 DOI: 10.1002/alz.12646 |
0.421 |
|
| 2022 |
Mann CN, Devi SS, Kersting CT, Bleem AV, Karch CM, Holtzman DM, Gallardo G. Astrocytic α2-Na/K ATPase inhibition suppresses astrocyte reactivity and reduces neurodegeneration in a tauopathy mouse model. Science Translational Medicine. 14: eabm4107. PMID 35171651 DOI: 10.1126/scitranslmed.abm4107 |
0.328 |
|
| 2022 |
Chhatwal JP, Schultz SA, McDade E, Schultz AP, Liu L, Hanseeuw BJ, Joseph-Mathurin N, Feldman R, Fitzpatrick CD, Sparks KP, Levin J, Berman SB, Renton AE, Esposito BT, Fernandez MV, ... ... Karch CM, et al. Variant-dependent heterogeneity in amyloid β burden in autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analyses of an observational study. The Lancet. Neurology. 21: 140-152. PMID 35065037 DOI: 10.1016/S1474-4422(21)00375-6 |
0.694 |
|
| 2022 |
Filipello F, Goldsbury C, Feng YS, Locca A, Karch CM, Piccio L. Soluble TREM2: Innocent bystander or active player in neurological diseases? Neurobiology of Disease. 105630. PMID 35041990 DOI: 10.1016/j.nbd.2022.105630 |
0.363 |
|
| 2021 |
Rosene MJ, Hsu S, Martinez R, Norton J, Yan P, Cirrito JR, Lee JM, Cuervo AM, Goate AM, Cruchaga C, Karch CM. Defining the role of PLD3 in Alzheimer's disease pathology. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 17: e058730. PMID 34971168 DOI: 10.1002/alz.058730 |
0.615 |
|
| 2021 |
Minaya M, Martinez R, Eteleeb A, Cruchaga C, Harari O, Karch CM. Impact of MAPT mutations on transcriptomic signatures of FTLD brains and patient-derived pluripotent cell models. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 17: e058313. PMID 34971166 DOI: 10.1002/alz.058313 |
0.359 |
|
| 2021 |
Sexton C, Snyder H, Beher D, Boxer AL, Brannelly P, Brion JP, Buée L, Cacace AM, Chételat G, Citron M, DeVos SL, Diaz K, Feldman HH, Frost B, Goate AM, ... ... Karch CM, et al. Current directions in tau research: Highlights from Tau 2020. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 34581500 DOI: 10.1002/alz.12452 |
0.442 |
|
| 2021 |
Li F, Eteleeb A, Buchser W, Wang G, Xiong C, Payne PR, McDade E, Karch CM, Harari O, Cruchaga C. Weakly activated core inflammation pathways were identified as a central signaling mechanism contributing to the chronic neurodegeneration in Alzheimer's disease. Biorxiv : the Preprint Server For Biology. PMID 34494019 DOI: 10.1101/2021.08.30.458295 |
0.716 |
|
| 2021 |
Chen CD, Joseph-Mathurin N, Sinha N, Zhou A, Li Y, Friedrichsen K, McCullough A, Franklin EE, Hornbeck R, Gordon B, Sharma V, Cruchaga C, Goate A, Karch C, McDade E, et al. Comparing amyloid-β plaque burden with antemortem PiB PET in autosomal dominant and late-onset Alzheimer disease. Acta Neuropathologica. PMID 34319442 DOI: 10.1007/s00401-021-02342-y |
0.576 |
|
| 2021 |
Bowles KR, Silva MC, Whitney K, Bertucci T, Berlind JE, Lai JD, Garza JC, Boles NC, Mahali S, Strang KH, Marsh JA, Chen C, Pugh DA, Liu Y, Gordon RE, ... ... Karch CM, et al. ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids. Cell. PMID 34314701 DOI: 10.1016/j.cell.2021.07.003 |
0.466 |
|
| 2021 |
Hernández D, Morgan Schlicht S, Daniszewski M, Karch CM, Goate AM, Pébay A. Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the London mutation in APP (V717I). Stem Cell Research. 53: 102373. PMID 34088002 DOI: 10.1016/j.scr.2021.102373 |
0.414 |
|
| 2021 |
Da Mesquita S, Papadopoulos Z, Dykstra T, Brase L, Farias FG, Wall M, Jiang H, Kodira CD, de Lima KA, Herz J, Louveau A, Goldman DH, Salvador AF, Onengut-Gumuscu S, Farber E, ... ... Karch CM, et al. Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy. Nature. PMID 33911285 DOI: 10.1038/s41586-021-03489-0 |
0.759 |
|
| 2021 |
Caballero B, Bourdenx M, Luengo E, Diaz A, Sohn PD, Chen X, Wang C, Juste YR, Wegmann S, Patel B, Young ZT, Kuo SY, Rodriguez-Navarro JA, Shao H, Lopez MG, ... Karch CM, et al. Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice. Nature Communications. 12: 2238. PMID 33854069 DOI: 10.1038/s41467-021-22501-9 |
0.489 |
|
| 2021 |
Ewers M, Luan Y, Frontzkowski L, Neitzel J, Rubinski A, Dichgans M, Hassenstab J, Gordon BA, Chhatwal JP, Levin J, Schofield P, Benzinger TLS, Morris JC, Goate A, Karch CM, et al. Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease. Brain : a Journal of Neurology. PMID 33725114 DOI: 10.1093/brain/awab112 |
0.641 |
|
| 2021 |
Joseph-Mathurin N, Wang G, Kantarci K, Jack CR, McDade E, Hassenstab J, Blazey TM, Gordon BA, Su Y, Chen G, Massoumzadeh P, Hornbeck RC, Allegri RF, Ances BM, Berman SB, ... ... Karch CM, et al. Longitudinal Accumulation of Cerebral Microhemorrhages in Dominantly Inherited Alzheimer Disease. Neurology. PMID 33495373 DOI: 10.1212/WNL.0000000000011542 |
0.567 |
|
| 2021 |
Luckett PH, McCullough A, Gordon BA, Strain J, Flores S, Dincer A, McCarthy J, Kuffner T, Stern A, Meeker KL, Berman SB, Chhatwal JP, Cruchaga C, Fagan AM, Farlow MR, ... ... Karch CM, et al. Modeling autosomal dominant Alzheimer's disease with machine learning. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33480178 DOI: 10.1002/alz.12259 |
0.504 |
|
| 2021 |
Smith R, Strain J, Tanenbaum A, Fagan A, Hassenstab J, Mcdade E, Schindler S, Gordon B, Xiong C, Chhatwal J, Jack CR, Karch C, Berman S, Brosch J, Lah J, et al. Resting-State Functional Connectivity Disruption as a Pathological Biomarker in Autosomal Dominant Alzheimer Disease. Brain Connectivity. PMID 33430685 DOI: 10.1089/brain.2020.0808 |
0.332 |
|
| 2020 |
Montal V, Vilaplana E, Pegueroles J, Bejanin A, Alcolea D, Carmona-Iragui M, Clarimón J, Levin J, Cruchaga C, Graff-Radford NR, Noble JM, Lee JH, Allegri R, Karch CM, Laske C, et al. Biphasic cortical macro- and microstructural changes in autosomal dominant Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33196147 DOI: 10.1002/alz.12224 |
0.6 |
|
| 2020 |
Vermunt L, Dicks E, Wang G, Dincer A, Flores S, Keefe SJ, Berman SB, Cash DM, Chhatwal JP, Cruchaga C, Fox NC, Ghetti B, Graff-Radford NR, Hassenstab J, Karch CM, et al. Single-subject grey matter network trajectories over the disease course of autosomal dominant Alzheimer's disease. Brain Communications. 2: fcaa102. PMID 32954344 DOI: 10.1093/braincomms/fcaa102 |
0.523 |
|
| 2020 |
Finsterwalder S, Vlegels N, Gesierich B, Araque Caballero MÁ, Weaver NA, Franzmeier N, Georgakis MK, Konieczny MJ, Koek HL, Karch CM, Graff-Radford NR, Salloway S, Oh H, Allegri RF, Chhatwal JP, et al. Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32808747 DOI: 10.1002/Alz.12150 |
0.442 |
|
| 2020 |
Schultz SA, Strain JF, Adedokun A, Wang Q, Preische O, Kuhle J, Flores S, Keefe S, Dincer A, Ances BM, Berman SB, Brickman AM, Cash DM, Chhatwal J, Cruchaga C, ... ... Karch CM, et al. Serum neurofilament light chain levels are associated with white matter integrity in autosomal dominant Alzheimer's disease. Neurobiology of Disease. 104960. PMID 32522711 DOI: 10.1016/J.Nbd.2020.104960 |
0.614 |
|
| 2020 |
Gregory JA, Hoelzli E, Abdelaal R, Braine C, Cuevas M, Halpern M, Barretto N, Schrode N, Akbalik G, Kang K, Cheng E, Bowles K, Lotz S, Goderie S, Karch CM, et al. Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models. Cells. 9. PMID 32516938 DOI: 10.3390/Cells9061406 |
0.495 |
|
| 2020 |
Xu Y, Du S, Marsh JA, Horie K, Sato C, Ballabio A, Karch CM, Holtzman DM, Zheng H. TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading. Molecular Psychiatry. PMID 32366951 DOI: 10.1038/S41380-020-0738-0 |
0.423 |
|
| 2020 |
Barthélemy NR, Li Y, Joseph-Mathurin N, Gordon BA, Hassenstab J, Benzinger TLS, Buckles V, Fagan AM, Perrin RJ, Goate AM, Morris JC, Karch CM, Xiong C, Allegri R, Mendez PC, et al. A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease. Nature Medicine. 26: 398-407. PMID 32161412 DOI: 10.1038/S41591-020-0781-Z |
0.607 |
|
| 2020 |
Hsu S, Pimenova AA, Hayes K, Villa JA, Rosene MJ, Jere M, Goate AM, Karch CM. Systematic validation of variants of unknown significance in APP, PSEN1 and PSEN2. Neurobiology of Disease. 104817. PMID 32087291 DOI: 10.1016/J.Nbd.2020.104817 |
0.62 |
|
| 2020 |
Franzmeier N, Koutsouleris N, Benzinger T, Goate A, Karch CM, Fagan AM, McDade E, Duering M, Dichgans M, Levin J, Gordon BA, Lim YY, Masters CL, Rossor M, Fox NC, et al. Predicting sporadic Alzheimer's disease progression via inherited Alzheimer's disease-informed machine-learning. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32043733 DOI: 10.1002/Alz.12032 |
0.6 |
|
| 2020 |
Alquezar C, Felix JB, McCandlish E, Buckley BT, Caparros-Lefebvre D, Karch CM, Golbe LI, Kao AW. Heavy metals contaminating the environment of a progressive supranuclear palsy cluster induce tau accumulation and cell death in cultured neurons. Scientific Reports. 10: 569. PMID 31953414 DOI: 10.1038/S41598-019-56930-W |
0.356 |
|
| 2020 |
Aschenbrenner AJ, James BD, McDade E, Wang G, Lim YY, Benzinger TLS, Cruchaga C, Goate A, Xiong C, Perrin R, Buckles V, Allegri R, Berman SB, Chhatwal JP, Fagan A, ... ... Karch CM, et al. Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN). Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 16: 219-228. PMID 31914221 DOI: 10.1002/Alz.12010 |
0.646 |
|
| 2020 |
Dincer A, Gordon BA, Hari-Raj A, Keefe SJ, Flores S, McKay NS, Paulick AM, Shady Lewis KE, Feldman RL, Hornbeck RC, Allegri R, Ances BM, Berman SB, Brickman AM, Brooks WS, ... ... Karch CM, et al. Comparing cortical signatures of atrophy between late-onset and autosomal dominant Alzheimer disease Neuroimage: Clinical. 28: 102491. DOI: 10.1016/j.nicl.2020.102491 |
0.369 |
|
| 2019 |
Llibre-Guerra JJ, Li Y, Schindler SE, Gordon BA, Fagan AM, Morris JC, Benzinger TLS, Hassenstab J, Wang G, Allegri R, Berman SB, Chhatwal J, Farlow MR, Holtzman DM, Jucker M, ... ... Karch C, et al. Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease. Jama Network Open. 2: e1917126. PMID 31825500 DOI: 10.1001/jamanetworkopen.2019.17126 |
0.364 |
|
| 2019 |
Sirkis DW, Geier EG, Bonham LW, Karch CM, Yokoyama JS. Recent advances in the genetics of frontotemporal dementia. Current Genetic Medicine Reports. 7: 41-52. PMID 31687268 DOI: 10.1007/S40142-019-0160-6 |
0.365 |
|
| 2019 |
Karch CM, Kao AW, Karydas A, Onanuga K, Martinez R, Argouarch A, Wang C, Huang C, Sohn PD, Bowles KR, Spina S, Silva MC, Marsh JA, Hsu S, Pugh DA, et al. A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies. Stem Cell Reports. PMID 31631020 DOI: 10.1016/J.Stemcr.2019.09.006 |
0.556 |
|
| 2019 |
Dube U, Del-Aguila JL, Li Z, Budde JP, Jiang S, Hsu S, Ibanez L, Fernandez MV, Farias F, Norton J, Gentsch J, Wang F, Salloway S, Masters CL, ... ... Karch CM, et al. An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations. Nature Neuroscience. PMID 31591557 DOI: 10.1038/S41593-019-0501-5 |
0.769 |
|
| 2019 |
Nakamura M, Shiozawa S, Tsuboi D, Amano M, Watanabe H, Maeda S, Kimura T, Yoshimatsu S, Kisa F, Karch CM, Miyasaka T, Takashima A, Sahara N, Hisanaga SI, Ikeuchi T, et al. Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs. Stem Cell Reports. PMID 31543469 DOI: 10.1016/J.Stemcr.2019.08.011 |
0.463 |
|
| 2019 |
Sohn PD, Huang CT, Yan R, Fan L, Tracy TE, Camargo CM, Montgomery KM, Arhar T, Mok SA, Freilich R, Baik J, He M, Gong S, Roberson ED, Karch CM, et al. Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis. Neuron. PMID 31542321 DOI: 10.1016/J.Neuron.2019.08.008 |
0.359 |
|
| 2019 |
Deming Y, Filipello F, Cignarella F, Cantoni C, Hsu S, Mikesell R, Li Z, Del-Aguila JL, Dube U, Farias FG, Bradley J, Budde J, Ibanez L, Fernandez MV, Blennow K, ... ... Karch CM, et al. The gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk. Science Translational Medicine. 11. PMID 31413141 DOI: 10.1126/Scitranslmed.Aau2291 |
0.805 |
|
| 2019 |
Bonham LW, Steele NZR, Karch CM, Broce I, Geier EG, Wen NL, Momeni P, Hardy J, Miller ZA, Gorno-Tempini ML, Hess CP, Lewis P, Miller BL, Seeley WW, Manzoni C, et al. Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia. Scientific Reports. 9: 10854. PMID 31350420 DOI: 10.1038/S41598-019-46415-1 |
0.5 |
|
| 2019 |
Paterson RW, Gabelle A, Lucey BP, Barthélemy NR, Leckey CA, Hirtz C, Lehmann S, Sato C, Patterson BW, West T, Yarasheski K, Rohrer JD, Wildburger NC, Schott JM, Karch CM, et al. SILK studies - capturing the turnover of proteins linked to neurodegenerative diseases. Nature Reviews. Neurology. PMID 31222062 DOI: 10.1038/S41582-019-0222-0 |
0.492 |
|
| 2019 |
Hernandez I, Luna G, Rauch JN, Reis SA, Giroux M, Karch CM, Boctor D, Sibih YE, Storm NJ, Diaz A, Kaushik S, Zekanowski C, Kang AA, Hinman CR, Cerovac V, et al. A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy. Science Translational Medicine. 11. PMID 30918111 DOI: 10.1126/Scitranslmed.Aat3005 |
0.554 |
|
| 2019 |
Franzmeier N, Ren J, Damm A, Monté-Rubio G, Boada M, Ruiz A, Ramirez A, Jessen F, Düzel E, Rodríguez Gómez O, Benzinger T, Goate A, Karch CM, Fagan AM, McDade E, et al. The BDNF SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease. Molecular Psychiatry. PMID 30899092 DOI: 10.1038/S41380-019-0404-6 |
0.583 |
|
| 2019 |
Vöglein J, Paumier K, Jucker M, Preische O, McDade E, Hassenstab J, Benzinger TL, Noble JM, Berman SB, Graff-Radford NR, Ghetti B, Farlow MR, Chhatwal J, Salloway S, Xiong C, ... Karch CM, et al. Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease. Brain : a Journal of Neurology. PMID 30897203 DOI: 10.1093/Brain/Awz050 |
0.558 |
|
| 2019 |
Sirkis DW, Bonham LW, Karch CM, Yokoyama JS. Immunological signatures in frontotemporal lobar degeneration. Current Opinion in Neurology. PMID 30672824 DOI: 10.1097/Wco.0000000000000665 |
0.346 |
|
| 2019 |
Tavana JP, Rosene M, Jensen NO, Ridge PG, Kauwe JS, Karch CM. RAB10: an Alzheimer's disease resilience locus and potential drug target. Clinical Interventions in Aging. 14: 73-79. PMID 30643396 DOI: 10.2147/Cia.S159148 |
0.703 |
|
| 2019 |
Suárez-Calvet M, Morenas-Rodríguez E, Kleinberger G, Schlepckow K, Caballero MÁA, Franzmeier N, Capell A, Fellerer K, Nuscher B, Eren E, Levin J, Deming Y, Piccio L, Karch CM, Cruchaga C, et al. Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology. Molecular Neurodegeneration. 14: 1. PMID 30630532 DOI: 10.1186/S13024-018-0301-5 |
0.653 |
|
| 2019 |
Cruchaga C, Benitez B, Karch CM, Piccio L. O3-13-06: The Ms4A Gene Cluster Is A Key Modulator Of Soluble Trem2 And Alzheimer Disease Risk Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.4701 |
0.563 |
|
| 2019 |
Mahali S, Jiang S, Hsu S, Benitez B, Harari O, Cruchaga C, Karch CM. O3-07-02: LYSOSOMAL DYSFUNCTION IN STEM CELL MODELS OF TAUOPATHY Alzheimer's & Dementia. 15: P897-P898. DOI: 10.1016/J.Jalz.2019.06.4661 |
0.441 |
|
| 2019 |
Theofilas P, Hayath M, Wang C, Butler D, McAllen S, Arkin M, Gestwicki J, Cuervo AM, Kayed R, Karch CM, Temple S, Gan L, Grinberg LT. P3-200: Tau-Mediated Cell Death Mechanisms In Mapt V337M Ipsc-Derived Human Neurons Alzheimers & Dementia. 15: 1006. DOI: 10.1016/J.Jalz.2019.06.3229 |
0.305 |
|
| 2018 |
Jiang S, Wen N, Li Z, Dube U, Del Aguila J, Budde J, Martinez R, Hsu S, Fernandez MV, Cairns NJ, Harari O, Cruchaga C, Karch CM. Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP. Translational Psychiatry. 8: 265. PMID 30546007 DOI: 10.1038/S41398-018-0319-Z |
0.746 |
|
| 2018 |
Suárez-Calvet M, Capell A, Araque Caballero MÁ, Morenas-Rodríguez E, Fellerer K, Franzmeier N, Kleinberger G, Eren E, Deming Y, Piccio L, Karch CM, Cruchaga C, Paumier K, Bateman RJ, Fagan AM, et al. CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline. Embo Molecular Medicine. PMID 30482868 DOI: 10.15252/Emmm.201809712 |
0.688 |
|
| 2018 |
Twohig D, Rodriguez-Vieitez E, Sando SB, Berge G, Lauridsen C, Møller I, Grøntvedt GR, Bråthen G, Patra K, Bu G, Benzinger TLS, Karch CM, Fagan A, Morris JC, Bateman RJ, et al. The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease. Acta Neuropathologica Communications. 6: 130. PMID 30477568 DOI: 10.1186/S40478-018-0624-Z |
0.536 |
|
| 2018 |
Joseph-Mathurin N, Su Y, Blazey TM, Jasielec M, Vlassenko A, Friedrichsen K, Gordon BA, Hornbeck RC, Cash L, Ances BM, Veale T, Cash DM, Brickman AM, Buckles V, Cairns NJ, ... ... Karch C, et al. Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease. Alzheimer's & Dementia (Amsterdam, Netherlands). 10: 669-677. PMID 30417072 DOI: 10.1016/J.Dadm.2018.08.012 |
0.592 |
|
| 2018 |
Broce IJ, Tan CH, Fan CC, Jansen I, Savage JE, Witoelar A, Wen N, Hess CP, Dillon WP, Glastonbury CM, Glymour M, Yokoyama JS, Elahi FM, Rabinovici GD, Miller BL, ... ... Karch CM, et al. Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease. Acta Neuropathologica. PMID 30413934 DOI: 10.1007/S00401-018-1928-6 |
0.509 |
|
| 2018 |
Bonham LW, Steele NZR, Karch CM, Manzoni C, Geier EG, Wen N, Ofori-Kuragu A, Momeni P, Hardy J, Miller ZA, Hess CP, Lewis P, Miller BL, Seeley WW, Baranzini SE, et al. Protein network analysis reveals selectively vulnerable regions and biological processes in FTD. Neurology. Genetics. 4: e266. PMID 30283816 DOI: 10.1212/Nxg.0000000000000266 |
0.51 |
|
| 2018 |
Araque Caballero MÁ, Suárez-Calvet M, Duering M, Franzmeier N, Benzinger T, Fagan AM, Bateman RJ, Jack CR, Levin J, Dichgans M, Jucker M, Karch C, Masters CL, Morris JC, Weiner M, et al. White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease. Brain : a Journal of Neurology. PMID 30239611 DOI: 10.1093/Brain/Awy229 |
0.565 |
|
| 2018 |
Li Y, Barkovich MJ, Karch CM, Nillo RM, Fan CC, Broce IJ, Tan CH, Cuneo D, Hess CP, Dillon WP, Glenn OA, Glastonbury CM, Olney N, Yokoyama JS, Bonham LW, et al. Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex. Scientific Reports. 8: 13373. PMID 30190613 DOI: 10.1038/S41598-018-31075-4 |
0.32 |
|
| 2018 |
Karch CM, Hernández D, Wang JC, Marsh J, Hewitt AW, Hsu S, Norton J, Levitch D, Donahue T, Sigurdson W, Ghetti B, Farlow M, Chhatwal J, Berman S, Cruchaga C, et al. Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network. Alzheimer's Research & Therapy. 10: 69. PMID 30045758 DOI: 10.1186/S13195-018-0400-0 |
0.683 |
|
| 2018 |
Hsu S, Gordon BA, Hornbeck R, Norton JB, Levitch D, Louden A, Ziegemeier E, Laforce R, Chhatwal J, Day GS, McDade E, Morris JC, Fagan AM, Benzinger TLS, Goate AM, ... ... Karch CM, et al. Discovery and validation of autosomal dominant Alzheimer's disease mutations. Alzheimer's Research & Therapy. 10: 67. PMID 30021643 DOI: 10.1186/S13195-018-0392-9 |
0.73 |
|
| 2018 |
Li Z, Del-Aguila JL, Dube U, Budde J, Martinez R, Black K, Xiao Q, Cairns NJ, Dougherty JD, Lee JM, Morris JC, Bateman RJ, Karch CM, Cruchaga C, et al. Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure. Genome Medicine. 10: 43. PMID 29880032 DOI: 10.1186/S13073-018-0551-4 |
0.793 |
|
| 2018 |
Bonham LW, Karch CM, Fan CC, Tan C, Geier EG, Wang Y, Wen N, Broce IJ, Li Y, Barkovich MJ, Ferrari R, Hardy J, Momeni P, Höglinger G, Müller U, et al. CXCR4 involvement in neurodegenerative diseases. Translational Psychiatry. 8: 73. PMID 29636460 DOI: 10.1038/S41398-017-0049-7 |
0.6 |
|
| 2018 |
Karch CM, Wen N, Fan CC, Yokoyama JS, Kouri N, Ross OA, Höglinger G, Müller U, Ferrari R, Hardy J, Schellenberg GD, Sleiman PM, Momeni P, Hess CP, Miller BL, et al. Selective Genetic Overlap Between Amyotrophic Lateral Sclerosis and Diseases of the Frontotemporal Dementia Spectrum. Jama Neurology. PMID 29630712 DOI: 10.1001/Jamaneurol.2018.0372 |
0.467 |
|
| 2018 |
Sato C, Barthélemy NR, Mawuenyega KG, Patterson BW, Gordon BA, Jockel-Balsarotti J, Sullivan M, Crisp MJ, Kasten T, Kirmess KM, Kanaan NM, Yarasheski KE, Baker-Nigh A, Benzinger TLS, Miller TM, ... Karch CM, et al. Tau Kinetics in Neurons and the Human Central Nervous System. Neuron. 97: 1284-1298.e7. PMID 29566794 DOI: 10.1016/J.Neuron.2018.02.015 |
0.399 |
|
| 2018 |
Broce I, Karch CM, Wen N, Fan CC, Wang Y, Tan CH, Kouri N, Ross OA, Höglinger GU, Muller U, Hardy J, Momeni P, Hess CP, Dillon WP, et al. Correction: Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies. Plos Medicine. 15: e1002504. PMID 29377952 DOI: 10.1371/journal.pmed.1002504 |
0.37 |
|
| 2018 |
Ridge PG, Karch CM, Hsu S, Arano I, Teerlink CC, Ebbert MTW, Murcia JDG, Farnham JM, Damato AR, Allen M, Wang X, Harari O, Fernandez VM, Guerreiro R, Bras J, et al. Correction to: Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome Medicine. 10: 4. PMID 29329552 DOI: 10.1186/S13073-018-0516-7 |
0.806 |
|
| 2018 |
Broce I, Karch CM, Wen N, Fan CC, Wang Y, Hong Tan C, Kouri N, Ross OA, Höglinger GU, Muller U, Hardy J, Momeni P, Hess CP, Dillon WP, et al. Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies. Plos Medicine. 15: e1002487. PMID 29315334 DOI: 10.1371/Journal.Pmed.1002487 |
0.491 |
|
| 2018 |
Mahali S, Hsu S, Benitez B, Martinez R, Goate AM, Karch C, Dian. O2-12-01: Lysosomal Dysfunction And Altered Tau Metabolism In Stem Cell Models Of Autosomal Dominant Alzheimer'S Disease Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.2706 |
0.559 |
|
| 2017 |
Ridge PG, Karch CM, Hsu S, Arano I, Teerlink CC, Ebbert MTW, Gonzalez Murcia JD, Farnham JM, Damato AR, Allen M, Wang X, Harari O, Fernandez VM, Guerreiro R, Bras J, et al. Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome Medicine. 9: 100. PMID 29183403 DOI: 10.1186/S13073-017-0486-1 |
0.816 |
|
| 2017 |
Tan CH, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Dillon WP, Bonham LW, Yokoyama JS, Karch CM, Brewer JB, Rabinovici GD, Miller BL, Schellenberg GD, Kauppi K, et al. Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition. Acta Neuropathologica. PMID 29177679 DOI: 10.1007/S00401-017-1789-4 |
0.339 |
|
| 2017 |
Tan CH, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Dillon WP, Bonham LW, Yokoyama JS, Karch CM, Brewer JB, Rabinovici GD, Miller BL, Schellenberg GD, Kauppi K, et al. Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition. Acta Neuropathologica. PMID 29177679 DOI: 10.1007/S00401-017-1789-4 |
0.339 |
|
| 2017 |
Wang C, Ward ME, Chen R, Liu K, Tracy TE, Chen X, Xie M, Sohn PD, Ludwig C, Meyer-Franke A, Karch CM, Ding S, Gan L. Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening. Stem Cell Reports. PMID 28966121 DOI: 10.1016/J.Stemcr.2017.08.019 |
0.34 |
|
| 2017 |
Tcw J, Wang M, Pimenova AA, Bowles KR, Hartley BJ, Lacin E, Machlovi SI, Abdelaal R, Karch CM, Phatnani H, Slesinger PA, Zhang B, Goate AM, Brennand KJ. An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells. Stem Cell Reports. PMID 28757165 DOI: 10.1016/J.Stemcr.2017.06.018 |
0.431 |
|
| 2017 |
Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, ... Karch CM, et al. Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. Plos Medicine. 14: e1002258. PMID 28323831 DOI: 10.1371/Journal.Pmed.1002258 |
0.667 |
|
| 2017 |
Yokoyama JS, Karch CM, Fan CC, Bonham LW, Kouri N, Ross OA, Rademakers R, Kim J, Wang Y, Höglinger GU, Müller U, Ferrari R, Hardy J, Momeni P, et al. Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia. Acta Neuropathologica. PMID 28271184 DOI: 10.1007/S00401-017-1693-Y |
0.526 |
|
| 2017 |
Karch C, Hsu S, Martinez R, Norton J, Cirrito JR, Lee J, Cuervo M, Cruchaga C, Goate A. [O2-18-02]: PHOSPHOLIPASE D3 CONTRIBUTES TO ALZHEIMER's DISEASE RISK VIA DISRUPTION OF Aβ CLEARANCE THROUGH THE LYSOSOME Alzheimer's & Dementia. 13: P602-P603. DOI: 10.1016/J.Jalz.2017.07.248 |
0.682 |
|
| 2016 |
Kober DL, Alexander-Brett JM, Karch CM, Cruchaga C, Colonna M, Holtzman MJ, Brett TJ. Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms. Elife. 5. PMID 27995897 DOI: 10.7554/Elife.20391 |
0.609 |
|
| 2016 |
Ferrari R, Wang Y, Vandrovcova J, Guelfi S, Witeolar A, Karch CM, Schork AJ, Fan CC, Brewer JB, Momeni P, Schellenberg GS, Dillon WP, et al. Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 27899424 DOI: 10.1136/Jnnp-2016-314411 |
0.588 |
|
| 2016 |
Yokoyama JS, Wang Y, Schork AJ, Thompson WK, Karch CM, Cruchaga C, McEvoy LK, Witoelar A, Chen CH, Holland D, Brewer JB, Franke A, Dillon WP, Wilson DM, Mukherjee P, et al. Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease. Jama Neurology. PMID 27088644 DOI: 10.1001/Jamaneurol.2016.0150 |
0.663 |
|
| 2016 |
Karch CM, Ezerskiy LA, Bertelsen S, Goate AM. Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci. Plos One. 11: e0148717. PMID 26919393 DOI: 10.1371/Journal.Pone.0148717 |
0.578 |
|
| 2016 |
Kober DL, Alexander-Brett JM, Karch CM, Cruchaga C, Colonna M, Holtzman MJ, Brett TJ. Author response: Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms Elife. DOI: 10.7554/Elife.20391.021 |
0.517 |
|
| 2016 |
Kauwe K, Arano I, Bras JT, Cannon-Albright L, Cruchaga C, Goate AM, Murcia JDG, Guerreiro R, Hardy J, Hsu S, Karch C, Munger RG, Norton MC, Ridge PG, Sassi C, et al. Linkage And Whole Genome Sequence Analysis Of Alzheimer'S Disease Resilience And Risk Alzheimers & Dementia. 12: 675. DOI: 10.1016/J.Jalz.2016.06.1325 |
0.7 |
|
| 2015 |
Karch CM, Ezerskiy L, Redaelli V, Giovagnoli AR, Tiraboschi P, Pelliccioni G, Pelliccioni P, Kapetis D, D'Amato I, Piccoli E, Ferretti MG, Tagliavini F, Rossi G. Missense mutations in progranulin gene associated with frontotemporal lobar degeneration: study of pathogenetic features. Neurobiology of Aging. PMID 26652843 DOI: 10.1016/J.Neurobiolaging.2015.10.029 |
0.325 |
|
| 2015 |
Karch CM, Goate AM. Alzheimer's disease risk genes and mechanisms of disease pathogenesis. Biological Psychiatry. 77: 43-51. PMID 24951455 DOI: 10.1016/J.Biopsych.2014.05.006 |
0.634 |
|
| 2015 |
Karch C, Hsu S, Ezerskiy L, Martinez R, Norton J, Cruchaga C, Goate AM. S2-02-04: Phospholipase D3 contributes to Alzheimer's disease risk via disruption in app trafficking and Aβ generation Alzheimer's & Dementia. 11: P163-P163. DOI: 10.1016/J.Jalz.2015.07.106 |
0.695 |
|
| 2015 |
Karch C, Martinez R, Hsu S, Ezerskiy L, Norton J, Goate A. O1-06-01: Modeling tauopathies in human pluripotent stem cells Alzheimer's & Dementia. 11: P138-P138. DOI: 10.1016/J.Jalz.2015.07.057 |
0.398 |
|
| 2014 |
Kauwe JS, Bailey MH, Ridge PG, Perry R, Wadsworth ME, Hoyt KL, Staley LA, Karch CM, Harari O, Cruchaga C, Ainscough BJ, Bales K, Pickering EH, Bertelsen S, et al. Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation. Plos Genetics. 10: e1004758. PMID 25340798 DOI: 10.1371/Journal.Pgen.1004758 |
0.834 |
|
| 2014 |
Karch CM, Cruchaga C, Goate AM. Alzheimer's disease genetics: from the bench to the clinic. Neuron. 83: 11-26. PMID 24991952 DOI: 10.1016/J.Neuron.2014.05.041 |
0.723 |
|
| 2014 |
Jin SC, Benitez BA, Karch CM, Cooper B, Skorupa T, Carrell D, Norton JB, Hsu S, Harari O, Cai Y, Bertelsen S, Goate AM, Cruchaga C. Coding variants in TREM2 increase risk for Alzheimer's disease. Human Molecular Genetics. 23: 5838-46. PMID 24899047 DOI: 10.1093/Hmg/Ddu277 |
0.811 |
|
| 2014 |
Cruchaga C, Karch CM, Jin SC, Benitez BA, Cai Y, Guerreiro R, Harari O, Norton J, Budde J, Bertelsen S, Jeng AT, Cooper B, Skorupa T, Carrell D, Levitch D, et al. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease. Nature. 505: 550-4. PMID 24336208 DOI: 10.1038/Nature12825 |
0.819 |
|
| 2014 |
Goate AM, Karch C, Hsu S, Jeng AT, Sears R, Cruchaga C. O2-12-04: ALZHEIMER'S DISEASE RISK VARIANTS IN PHOSPHOLIPASE D3 ALTER APP METABOLISM BY GAMMA-DEPENDENT AND GAMMA-INDEPENDENT MECHANISMS Alzheimer's & Dementia. 10: P192-P192. DOI: 10.1016/J.Jalz.2014.04.225 |
0.658 |
|
| 2014 |
Cruchaga C, Jin SC, Benitez BA, Karch C, Goate A. O1-04-05: NOVEL CODING VARIANTS IN TREM2 INCREASE RISK FOR ALZHEIMER'S DISEASE Alzheimer's & Dementia. 10: P136-P136. DOI: 10.1016/J.Jalz.2014.04.078 |
0.662 |
|
| 2013 |
Benitez BA, Karch CM, Cai Y, Jin SC, Cooper B, Carrell D, Bertelsen S, Chibnik L, Schneider JA, Bennett DA, Fagan AM, Holtzman D, Morris JC, et al. The PSEN1, p.E318G variant increases the risk of Alzheimer's disease in APOE-ε4 carriers. Plos Genetics. 9: e1003685. PMID 23990795 DOI: 10.1371/Journal.Pgen.1003685 |
0.671 |
|
| 2013 |
Karch CM, Jeng AT, Skorupa T, Cruchaga C, Goate AM. Novel progranulin variants do not disrupt progranulin secretion and cleavage. Neurobiology of Aging. 34: 2538-40. PMID 23759146 DOI: 10.1016/J.Neurobiolaging.2013.05.004 |
0.663 |
|
| 2013 |
Cruchaga C, Kauwe JS, Harari O, Jin SC, Cai Y, Karch CM, Benitez BA, Jeng AT, Skorupa T, Carrell D, Bertelsen S, Bailey M, McKean D, Shulman JM, De Jager PL, et al. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. Neuron. 78: 256-68. PMID 23562540 DOI: 10.1016/J.Neuron.2013.02.026 |
0.824 |
|
| 2013 |
Karch CM, Jeng AT, Goate AM. Calcium phosphatase calcineurin influences tau metabolism. Neurobiology of Aging. 34: 374-86. PMID 22676853 DOI: 10.1016/J.Neurobiolaging.2012.05.003 |
0.627 |
|
| 2013 |
Benitez B, Karch C, Jin SC, Carrel D, Cooper B, Bertelsen S, Morris J, Holtzman D, Goate A, Cruchaga C. Rare variants in APP and PSEN1 genes associated with extreme levels of beta-amyloid 42 and tau protein in cerebrospinal fluid Alzheimers & Dementia. 9: 680. DOI: 10.1016/J.Jalz.2013.04.338 |
0.631 |
|
| 2012 |
Karch CM, Jeng AT, Nowotny P, Cady J, Cruchaga C, Goate AM. Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains. Plos One. 7: e50976. PMID 23226438 DOI: 10.1371/Journal.Pone.0050976 |
0.689 |
|
| 2012 |
Karch CM, Jeng AT, Goate AM. Extracellular Tau levels are influenced by variability in Tau that is associated with tauopathies. The Journal of Biological Chemistry. 287: 42751-62. PMID 23105105 DOI: 10.1074/Jbc.M112.380642 |
0.614 |
|
| 2012 |
Jeng A, Karch C, Nowotny P, Cruchaga C, Goate A. P4-085: ABCA7 and MS4A6A expression are upregulated in Alzheimer's disease brains Alzheimer's & Dementia. 8: P663-P663. DOI: 10.1016/J.Jalz.2012.05.1787 |
0.671 |
|
| 2011 |
Kauwe JS, Cruchaga C, Karch CM, Sadler B, Lee M, Mayo K, Latu W, Su'a M, Fagan AM, Holtzman DM, Morris JC, Goate AM. Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease. Plos One. 6: e15918. PMID 21347408 DOI: 10.1371/Journal.Pone.0015918 |
0.777 |
|
| 2011 |
Karch C, Jeng A, Goate A. O4-04-07: Extracellular tau levels in cultured cells are influenced by genetic variants associated with dementia Alzheimer's & Dementia. 7: S690-S691. DOI: 10.1016/J.Jalz.2011.05.1995 |
0.513 |
|
| 2010 |
Karch CM, Borchelt DR. Aggregation modulating elements in mutant human superoxide dismutase 1. Archives of Biochemistry and Biophysics. 503: 175-82. PMID 20682279 DOI: 10.1016/J.Abb.2010.07.027 |
0.547 |
|
| 2010 |
Karch CM, Borchelt DR. An examination of alpha B-crystallin as a modifier of SOD1 aggregate pathology and toxicity in models of familial amyotrophic lateral sclerosis. Journal of Neurochemistry. 113: 1092-100. PMID 20067574 DOI: 10.1111/J.1471-4159.2010.06572.X |
0.524 |
|
| 2010 |
Karch CM, Jeng A, Cruchaga C, Kauwe JS, Renaud N, Fagan AM, Holtzman DM, Morris JC, Goate AM. P1-090: The effects of Alzheimer's disease associated transferrin variants on APP metabolism Alzheimer's & Dementia. 6: S200-S200. DOI: 10.1016/J.Jalz.2010.05.638 |
0.765 |
|
| 2010 |
Winkler DD, Prudencio M, Karch C, Borchelt DR, Hart PJ. Copper-Zinc Superoxide Dismutase, Its Copper Chaperone, and Familial Amyotrophic Lateral Sclerosis Protein Misfolding Diseases: Current and Emerging Principles and Therapies. 381-401. DOI: 10.1002/9780470572702.ch17 |
0.625 |
|
| 2009 |
Seetharaman SV, Prudencio M, Karch C, Holloway SP, Borchelt DR, Hart PJ. Immature copper-zinc superoxide dismutase and familial amyotrophic lateral sclerosis. Experimental Biology and Medicine (Maywood, N.J.). 234: 1140-54. PMID 19596823 DOI: 10.3181/0903-Mr-104 |
0.702 |
|
| 2009 |
Karch CM, Prudencio M, Winkler DD, Hart PJ, Borchelt DR. Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS. Proceedings of the National Academy of Sciences of the United States of America. 106: 7774-9. PMID 19416874 DOI: 10.1073/Pnas.0902505106 |
0.711 |
|
| 2008 |
Xu G, Karch C, Li N, Lin N, Fromholt D, Gonzales V, Borchelt DR. Receptor-associated protein (RAP) plays a central role in modulating Abeta deposition in APP/PS1 transgenic mice. Plos One. 3: e3159. PMID 18776935 DOI: 10.1371/Journal.Pone.0003159 |
0.691 |
|
| 2008 |
Karch CM, Borchelt DR. A limited role for disulfide cross-linking in the aggregation of mutant SOD1 linked to familial amyotrophic lateral sclerosis. The Journal of Biological Chemistry. 283: 13528-37. PMID 18316367 DOI: 10.1074/Jbc.M800564200 |
0.547 |
|
| 2006 |
Jiang S, Li Z, Harari O, Budde JP, Dube U, Del Aguila J, Cruchaga C, Karch C. O5-04-03: IDENTIFICATION OF DIFFERENTIALLY EXPRESSED GENES AND POTENTIALLY NOVEL DRUGS FOR FRONTOTEMPORAL LOBAR DEMENTIA WITH TAU INCLUSIONS BY A DEPENDABLE ANALYSIS APPROACH Alzheimer's & Dementia. 14: P1651-P1652. DOI: 10.1016/J.Jalz.2018.06.3015 |
0.526 |
|
| 2006 |
Wen N, Li Z, Harari O, Cruchaga C, Karch C. P3-125: NUCLEOSKELETON DYSREGULATION IS MEDIATED BY LMNA IN ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P1115-P1115. DOI: 10.1016/J.Jalz.2018.06.1482 |
0.624 |
|
| 2005 |
Wang J, Xu G, Li H, Gonzales V, Fromholt D, Karch C, Copeland NG, Jenkins NA, Borchelt DR. Somatodendritic accumulation of misfolded SOD1-L126Z in motor neurons mediates degeneration: alphaB-crystallin modulates aggregation. Human Molecular Genetics. 14: 2335-47. PMID 16000321 DOI: 10.1093/Hmg/Ddi236 |
0.732 |
|
| Show low-probability matches. |