Nick Brandon - Publications

AstraZeneca LP, Canóvanas, Canóvanas, Puerto Rico 
Schizophrenia and Bioplar disorder

118 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Erli F, Palmos AB, Raval P, Mukherjee J, Sellers KJ, Gatford NJF, Moss SJ, Brandon NJ, Penzes P, Srivastava DP. Estradiol reverses excitatory synapse loss in a cellular model of neuropsychiatric disorders. Translational Psychiatry. 10: 16. PMID 32066698 DOI: 10.1038/s41398-020-0682-4  1
2019 Chadchankar J, Korboukh V, Conway LC, Wobst HJ, Walker CA, Doig P, Jacobsen SJ, Brandon NJ, Moss SJ, Wang Q. Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells. Plos One. 14: e0225145. PMID 31703099 DOI: 10.1371/journal.pone.0225145  1
2019 Plumbly W, Brandon N, Deeb TZ, Hall J, Harwood AJ. L-type voltage-gated calcium channel regulation of in vitro human cortical neuronal networks. Scientific Reports. 9: 13810. PMID 31554851 DOI: 10.1038/s41598-019-50226-9  0.84
2019 Moore YE, Conway LC, Wobst HJ, Brandon NJ, Deeb TZ, Moss SJ. Developmental Regulation of KCC2 Phosphorylation Has Long-Term Impacts on Cognitive Function. Frontiers in Molecular Neuroscience. 12: 173. PMID 31396048 DOI: 10.3389/fnmol.2019.00173  1
2019 Nathanson AJ, Zhang Y, Smalley JL, Ollerhead TA, Rodriguez Santos MA, Andrews PM, Wobst HJ, Moore YE, Brandon NJ, Hines RM, Davies PA, Moss SJ. Identification of a Core Amino Acid Motif within the α Subunit of GABARs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures. Cell Reports. 28: 670-681.e8. PMID 31315046 DOI: 10.1016/j.celrep.2019.06.014  1
2019 Huyghe D, Denninger AR, Voss CM, Frank P, Gao N, Brandon N, Waagepetersen HS, Ferguson AD, Pangalos M, Doig P, Moss SJ. Phosphorylation of Glutamine Synthetase on Threonine 301 Contributes to Its Inactivation During Epilepsy. Frontiers in Molecular Neuroscience. 12: 120. PMID 31178690 DOI: 10.3389/fnmol.2019.00120  1
2019 Read J, Collie IT, Nguyen-McCarty M, Lucaj C, Robinson J, Conway L, Mukherjee J, McCall E, Donohoe G, Flavell E, Peciak K, Warwicker J, Dix C, Van den Hoven BG, Madin A, ... ... Brandon NJ, et al. Tool inhibitors and assays to interrogate the biology of the TRAF2 and NCK interacting kinase. Bioorganic & Medicinal Chemistry Letters. PMID 31153805 DOI: 10.1016/j.bmcl.2019.05.032  0.36
2018 Moore YE, Deeb TZ, Chadchankar H, Brandon NJ, Moss SJ. Potentiating KCC2 activity is sufficient to limit the onset and severity of seizures. Proceedings of the National Academy of Sciences of the United States of America. PMID 30224498 DOI: 10.1073/pnas.1810134115  1
2018 Bürli RW, Wei H, Ernst G, Mariga A, Hardern IM, Herlihy K, Cross AJ, Wesolowski SS, Chen H, McKay RDG, Weinberger DR, Brandon NJ, Barrow JC. Novel inhibitors of As(III) S-adenosylmethionine methyltransferase (AS3MT) identified by virtual screening. Bioorganic & Medicinal Chemistry Letters. PMID 30170942 DOI: 10.1016/j.bmcl.2018.08.012  0.36
2018 Hines RM, Maric HM, Hines DJ, Modgil A, Panzanelli P, Nakamura Y, Nathanson AJ, Cross A, Deeb T, Brandon NJ, Davies P, Fritschy JM, Schindelin H, Moss SJ. Developmental seizures and mortality result from reducing GABA receptor α2-subunit interaction with collybistin. Nature Communications. 9: 3130. PMID 30087324 DOI: 10.1038/s41467-018-05481-1  1
2018 Kelley MR, Cardarelli RA, Smalley JL, Ollerhead TA, Andrew PM, Brandon NJ, Deeb TZ, Moss SJ. Locally Reducing KCC2 Activity in the Hippocampus is Sufficient to Induce Temporal Lobe Epilepsy. Ebiomedicine. PMID 29884458 DOI: 10.1016/j.ebiom.2018.05.029  1
2018 Fan J, Zhao RQ, Parro C, Zhao W, Chou HY, Robert J, Deeb TZ, Raynoschek C, Barichievy S, Engvist O, Maresca M, Hicks R, Meuller J, Moss SJ, Brandon NJ, et al. Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway. Journal of Lipid Research. PMID 29563219 DOI: 10.1194/jlr.M081851  1
2017 Cardarelli RA, Jones K, Pisella LI, Wobst HJ, McWilliams LJ, Sharpe PM, Burnham MP, Baker DJ, Chudotvorova I, Guyot J, Silayeva L, Morrow DH, Dekker N, Zicha S, Davies PA, ... ... Brandon NJ, et al. The small molecule CLP257 does not modify activity of the K+-Cl- co-transporter KCC2 but does potentiate GABAA receptor activity. Nature Medicine. 23: 1394-1396. PMID 29216042 DOI: 10.1038/nm.4442  1
2017 Dauvermann MR, Moorhead TW, Watson AR, Duff B, Romaniuk L, Hall J, Roberts N, Lee GL, Hughes ZA, Brandon NJ, Whitcher B, Blackwood DH, McIntosh AM, Lawrie SM. Verbal working memory and functional large-scale networks in schizophrenia. Psychiatry Research. 270: 86-96. PMID 29111478 DOI: 10.1016/j.pscychresns.2017.10.004  0.52
2017 Conway LC, Cardarelli RA, Moore YE, Jones K, McWilliams LJ, Baker DJ, Burnham MP, Bürli RW, Wang Q, Brandon NJ, Moss SJ, Deeb TZ. N-ethylmaleimide increases KCC2 activity by modulating transporter phosphorylation. The Journal of Biological Chemistry. PMID 29092909 DOI: 10.1074/jbc.M117.817841  1
2017 Mukherjee J, Cardarelli RA, Cantaut-Belarif Y, Deeb TZ, Srivastava DP, Tyagarajan SK, Pangalos MN, Triller A, Maguire J, Brandon NJ, Moss SJ. Estradiol modulates the efficacy of synaptic inhibition by decreasing the dwell time of GABAA receptors at inhibitory synapses. Proceedings of the National Academy of Sciences of the United States of America. PMID 29078280 DOI: 10.1073/pnas.1705075114  1
2017 Moore YE, Kelley MR, Brandon NJ, Deeb TZ, Moss SJ. Seizing Control of KCC2: A New Therapeutic Target for Epilepsy. Trends in Neurosciences. PMID 28803659 DOI: 10.1016/j.tins.2017.06.008  1
2017 Yalla K, Elliott C, Day JP, Findlay J, Barratt S, Hughes ZA, Wilson L, Whiteley E, Popiolek M, Li Y, Dunlop J, Killick R, Adams DR, Brandon NJ, Houslay MD, et al. FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system. Molecular Psychiatry. PMID 28727686 DOI: 10.1038/mp.2017.138  0.52
2017 Wobst HJ, Delsing L, Brandon NJ, Moss SJ. Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant. Plos One. 12: e0177181. PMID 28510586 DOI: 10.1371/journal.pone.0177181  1
2017 Wobst HJ, Wesolowski SS, Chadchankar J, Delsing L, Jacobsen S, Mukherjee J, Deeb TZ, Dunlop J, Brandon NJ, Moss SJ. Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro. Frontiers in Molecular Neuroscience. 10: 46. PMID 28286471 DOI: 10.3389/fnmol.2017.00046  1
2017 Kang JY, Chadchankar J, Vien TN, Mighdoll MI, Hyde TM, Mather RJ, Deeb TZ, Pangalos MN, Brandon NJ, Dunlop J, Moss SJ. Deficits in the activity of presynaptic γ-Aminobutyric acid type B receptors contribute to altered neuronal excitability in Fragile X Syndrome. The Journal of Biological Chemistry. PMID 28213518 DOI: 10.1074/jbc.M116.772541  1
2016 Kelley MR, Deeb TZ, Brandon NJ, Dunlop J, Davies PA, Moss SJ. Compromising KCC2 transporter activity enhances the development of continuous seizure activity. Neuropharmacology. PMID 27108931 DOI: 10.1016/j.neuropharm.2016.04.029  1
2016 Diggle CP, Sukoff Rizzo SJ, Popiolek M, Hinttala R, Schülke JP, Kurian MA, Carr IM, Markham AF, Bonthron DT, Watson C, Sharif SM, Reinhart V, James LC, Vanase-Frawley MA, Charych E, ... ... Brandon NJ, et al. Biallelic Mutations in PDE10A Lead to Loss of Striatal PDE10A and a Hyperkinetic Movement Disorder with Onset in Infancy. American Journal of Human Genetics. 98: 735-43. PMID 27058446 DOI: 10.1016/j.ajhg.2016.03.015  1
2016 Trossbach SV, Bader V, Hecher L, Pum ME, Masoud ST, Prikulis I, Schäble S, de Souza Silva MA, Su P, Boulat B, Chwiesko C, Poschmann G, Stühler K, Lohr KM, Stout KA, ... ... Brandon NJ, et al. Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and behavioral deficits. Molecular Psychiatry. PMID 26754951 DOI: 10.1038/mp.2015.194  0.6
2016 Saito A, Taniguchi Y, Rannals MD, Merfeld EB, Ballinger MD, Koga M, Ohtani Y, Gurley DA, Sedlak TW, Cross A, Moss SJ, Brandon NJ, Maher BJ, Kamiya A. Early postnatal GABAA receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1. Molecular Psychiatry. PMID 26728564 DOI: 10.1038/mp.2015.203  1
2015 Vien TN, Modgil A, Abramian AM, Jurd R, Walker J, Brandon NJ, Terunuma M, Rudolph U, Maguire J, Davies PA, Moss SJ. Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disorders. Proceedings of the National Academy of Sciences of the United States of America. 112: 14805-10. PMID 26627235 DOI: 10.1073/pnas.1514657112  1
2015 Gould RW, Nedelcovych MT, Gong X, Tsai E, Bubser M, Bridges TM, Wood MR, Duggan ME, Brandon NJ, Dunlop J, Wood MW, Ivarsson M, Noetzel MJ, Daniels JS, Niswender CM, et al. State-Dependent Alterations in Sleep/wake Architecture Elicited by the M4 PAM VU0467154- Relation to Antipsychotic-like Drug Effects. Neuropharmacology. PMID 26617071 DOI: 10.1016/j.neuropharm.2015.11.016  0.6
2015 Brandon NJ, McKay R. The cellular target of antidepressants. Nature Neuroscience. 18: 1537-8. PMID 26505563 DOI: 10.1038/nn.4144  1
2015 Whalley HC, Dimitrova R, Sprooten E, Dauvermann MR, Romaniuk L, Duff B, Watson AR, Moorhead B, Bastin M, Semple SI, Giles S, Hall J, Thomson P, Roberts N, Hughes ZA, ... Brandon NJ, et al. Effects of a Balanced Translocation between Chromosomes 1 and 11 Disrupting the DISC1 Locus on White Matter Integrity. Plos One. 10: e0130900. PMID 26102360 DOI: 10.1371/journal.pone.0130900  1
2015 Sivakumaran S, Cardarelli RA, Maguire J, Kelley MR, Silayeva L, Morrow DH, Mukherjee J, Moore YE, Mather RJ, Duggan ME, Brandon NJ, Dunlop J, Zicha S, Moss SJ, Deeb TZ. Selective Inhibition of KCC2 Leads to Hyperexcitability and Epileptiform Discharges in Hippocampal Slices and In Vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 8291-6. PMID 26019342 DOI: 10.1523/JNEUROSCI.5205-14.2015  1
2015 Dawson N, Kurihara M, Thomson DM, Winchester CL, McVie A, Hedde JR, Randall AD, Shen S, Seymour PA, Hughes ZA, Dunlop J, Brown JT, Brandon NJ, Morris BJ, Pratt JA. Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1. Translational Psychiatry. 5: e569. PMID 25989143 DOI: 10.1038/tp.2015.60  0.52
2015 Pritchett D, Hasan S, Tam SK, Engle SJ, Brandon NJ, Sharp T, Foster RG, Harrison PJ, Bannerman DM, Peirson SN. d-amino acid oxidase knockout (Dao(-/-) ) mice show enhanced short-term memory performance and heightened anxiety, but no sleep or circadian rhythm disruption. The European Journal of Neuroscience. 41: 1167-79. PMID 25816902 DOI: 10.1111/ejn.12880  1
2015 Silayeva L, Deeb TZ, Hines RM, Kelley MR, Munoz MB, Lee HH, Brandon NJ, Dunlop J, Maguire J, Davies PA, Moss SJ. KCC2 activity is critical in limiting the onset and severity of status epilepticus. Proceedings of the National Academy of Sciences of the United States of America. 112: 3523-8. PMID 25733865 DOI: 10.1073/pnas.1415126112  1
2015 Dunlop J, Brandon NJ. Schizophrenia drug discovery and development in an evolving era: are new drug targets fulfilling expectations? Journal of Psychopharmacology (Oxford, England). 29: 230-8. PMID 25586401 DOI: 10.1177/0269881114565806  1
2015 Shahani N, Seshadri S, Jaaro-Peled H, Ishizuka K, Hirota-Tsuyada Y, Wang Q, Koga M, Sedlak TW, Korth C, Brandon NJ, Kamiya A, Subramaniam S, Tomoda T, Sawa A. DISC1 regulates trafficking and processing of APP and Aβ generation. Molecular Psychiatry. 20: 874-9. PMID 25224257 DOI: 10.1038/mp.2014.100  1
2015 Wilson LS, Brandon NJ. Emerging biology of PDE10A. Current Pharmaceutical Design. 21: 378-88. PMID 25159072  1
2014 Schülke JP, McAllister LA, Geoghegan KF, Parikh V, Chappie TA, Verhoest PR, Schmidt CJ, Johnson DS, Brandon NJ. Chemoproteomics demonstrates target engagement and exquisite selectivity of the clinical phosphodiesterase 10A inhibitor MP-10 in its native environment. Acs Chemical Biology. 9: 2823-32. PMID 25295858 DOI: 10.1021/cb500671j  1
2014 Bubser M, Bridges TM, Dencker D, Gould RW, Grannan M, Noetzel MJ, Lamsal A, Niswender CM, Daniels JS, Poslusney MS, Melancon BJ, Tarr JC, Byers FW, Wess J, Duggan ME, ... ... Brandon NJ, et al. Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents. Acs Chemical Neuroscience. 5: 920-42. PMID 25137629 DOI: 10.1021/cn500128b  0.6
2014 Schweimer JV, Coullon GS, Betts JF, Burnet PW, Engle SJ, Brandon NJ, Harrison PJ, Sharp T. Increased burst-firing of ventral tegmental area dopaminergic neurons in D-amino acid oxidase knockout mice in vivo. The European Journal of Neuroscience. 40: 2999-3009. PMID 25040393 DOI: 10.1111/ejn.12667  1
2014 Randall AD, Kurihara M, Brandon NJ, Brown JT. Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system. The European Journal of Neuroscience. 39: 1068-73. PMID 24712987 DOI: 10.1111/ejn.12500  1
2014 Porteous DJ, Thomson PA, Millar JK, Evans KL, Hennah W, Soares DC, McCarthy S, McCombie WR, Clapcote SJ, Korth C, Brandon NJ, Sawa A, Kamiya A, Roder JC, Lawrie SM, et al. DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan. Molecular Psychiatry. 19: 141-3. PMID 24457522 DOI: 10.1038/mp.2013.160  1
2014 Hu X, Zhang B, Liu W, Paciga S, He W, Lanz TA, Kleiman R, Dougherty B, Hall SK, McIntosh AM, Lawrie SM, Power A, John SL, Blackwood D, St Clair D, ... Brandon NJ, et al. A survey of rare coding variants in candidate genes in schizophrenia by deep sequencing. Molecular Psychiatry. 19: 857-8. PMID 24126932 DOI: 10.1038/mp.2013.131  1
2014 Wei J, Graziane NM, Wang H, Zhong P, Wang Q, Liu W, Hayashi-Takagi A, Korth C, Sawa A, Brandon NJ, Yan Z. Regulation of N-methyl-D-aspartate receptors by disrupted-in-schizophrenia-1. Biological Psychiatry. 75: 414-24. PMID 23906531 DOI: 10.1016/j.biopsych.2013.06.009  1
2014 Charych EI, Brandon NJ. Molecular And Cellular Understanding of PDE10A: A Dual-Substrate Phosphodiesterase with Therapeutic Potential to Modulate Basal Ganglia Function Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System: From Biology to Drug Discovery. 247-268. DOI: 10.1002/9781118836507.ch10  1
2014 Zoubovsky SP, Sawa A, Brandon NJ. Emerging Role for PDE4 in Neuropsychiatric Disorders: Translating Advances from Genetic Studies Into Relevant Therapeutic Strategies Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System: From Biology to Drug Discovery. 211-222. DOI: 10.1002/9781118836507.ch08  1
2014 Brandon NJ, West AR. Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System: From Biology to Drug Discovery Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System: From Biology to Drug Discovery. 1-386. DOI: 10.1002/9781118836507  1
2014 Brandon NJ, West AR. Preface Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System: From Biology to Drug Discovery. vii-viii.  1
2013 Vithlani M, Hines RM, Zhong P, Terunuma M, Hines DJ, Revilla-Sanchez R, Jurd R, Haydon P, Rios M, Brandon N, Yan Z, Moss SJ. The ability of BDNF to modify neurogenesis and depressive-like behaviors is dependent upon phosphorylation of tyrosine residues 365/367 in the GABA(A)-receptor γ2 subunit. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 15567-77. PMID 24068823 DOI: 10.1523/JNEUROSCI.1845-13.2013  1
2013 Rizzo SJ, Edgerton JR, Hughes ZA, Brandon NJ. Future viable models of psychiatry drug discovery in pharma. Journal of Biomolecular Screening. 18: 509-21. PMID 23392517 DOI: 10.1177/1087057113475871  1
2013 Dunlop J, Brandon NJ. The road ahead: A perspective of drug discovery in psychiatry in 2013 from inside an evolving industry Biochemist. 35: 24-29.  1
2012 Sukoff Rizzo SJ, Neal SJ, Hughes ZA, Beyna M, Rosenzweig-Lipson S, Moss SJ, Brandon NJ. Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes. Translational Psychiatry. 2: e199. PMID 23212583 DOI: 10.1038/tp.2012.120  1
2012 Malamas MS, Stange H, Schindler R, Lankau HJ, Grunwald C, Langen B, Egerland U, Hage T, Ni Y, Erdei J, Fan KY, Parris K, Marquis KL, Grauer S, Brennan J, ... ... Brandon NJ, et al. Novel triazines as potent and selective phosphodiesterase 10A inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 5876-84. PMID 22902656 DOI: 10.1016/j.bmcl.2012.07.076  1
2012 Rais R, Thomas AG, Wozniak K, Wu Y, Jaaro-Peled H, Sawa A, Strick CA, Engle SJ, Brandon NJ, Rojas C, Slusher BS, Tsukamoto T. Pharmacokinetics of oral D-serine in D-amino acid oxidase knockout mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 2067-73. PMID 22837388 DOI: 10.1124/dmd.112.046482  1
2012 Zhou D, Gross JL, Adedoyin AB, Aschmies SB, Brennan J, Bowlby M, Di L, Kubek K, Platt BJ, Wang Z, Zhang G, Brandon N, Comery TA, Robichaud AJ. 2-(Pyrrolidin-1-yl)ethyl-3,4-dihydroisoquinolin-1(2H)-one derivatives as potent and selective histamine-3 receptor antagonists. Journal of Medicinal Chemistry. 55: 2452-68. PMID 22313242 DOI: 10.1021/jm300011d  1
2012 Atkin TA, Brandon NJ, Kittler JT. Disrupted in Schizophrenia 1 forms pathological aggresomes that disrupt its function in intracellular transport. Human Molecular Genetics. 21: 2017-28. PMID 22291444 DOI: 10.1093/hmg/dds018  1
2012 Sha L, MacIntyre L, Machell JA, Kelly MP, Porteous DJ, Brandon NJ, Muir WJ, Blackwood DH, Watson DG, Clapcote SJ, Pickard BS. Transcriptional regulation of neurodevelopmental and metabolic pathways by NPAS3. Molecular Psychiatry. 17: 267-79. PMID 21709683 DOI: 10.1038/mp.2011.73  1
2011 Brandon NJ, Sawa A. Linking neurodevelopmental and synaptic theories of mental illness through DISC1. Nature Reviews. Neuroscience. 12: 707-22. PMID 22095064 DOI: 10.1038/nrn3120  1
2011 Porteous DJ, Millar JK, Brandon NJ, Sawa A. DISC1 at 10: connecting psychiatric genetics and neuroscience. Trends in Molecular Medicine. 17: 699-706. PMID 22015021 DOI: 10.1016/j.molmed.2011.09.002  1
2011 Malamas MS, Ni Y, Erdei J, Stange H, Schindler R, Lankau HJ, Grunwald C, Fan KY, Parris K, Langen B, Egerland U, Hage T, Marquis KL, Grauer S, Brennan J, ... ... Brandon NJ, et al. Highly potent, selective, and orally active phosphodiesterase 10A inhibitors. Journal of Medicinal Chemistry. 54: 7621-38. PMID 21988093 DOI: 10.1021/jm2009138  1
2011 Zhou D, Gross JL, Sze JY, Adedoyin AB, Bowlby M, Di L, Platt BJ, Zhang G, Brandon N, Comery TA, Robichaud AJ. Pyrrolidin-3-yl-N-methylbenzamides as potent histamine 3 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 21: 5957-60. PMID 21843941 DOI: 10.1016/j.bmcl.2011.07.061  1
2011 Wang Q, Brandon NJ. Regulation of the cytoskeleton by Disrupted-in-schizophrenia 1 (DISC1). Molecular and Cellular Neurosciences. 48: 359-64. PMID 21757008 DOI: 10.1016/j.mcn.2011.06.004  1
2011 Popiolek M, Ross JF, Charych E, Chanda P, Gundelfinger ED, Moss SJ, Brandon NJ, Pausch MH. D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone. The Journal of Biological Chemistry. 286: 28867-75. PMID 21700703 DOI: 10.1074/jbc.M111.262063  1
2011 Atkin TA, MacAskill AF, Brandon NJ, Kittler JT. Disrupted in Schizophrenia-1 regulates intracellular trafficking of mitochondria in neurons. Molecular Psychiatry. 16: 122-4, 121. PMID 21079610 DOI: 10.1038/mp.2010.110  1
2011 Wang Q, Charych EI, Pulito VL, Lee JB, Graziane NM, Crozier RA, Revilla-Sanchez R, Kelly MP, Dunlop AJ, Murdoch H, Taylor N, Xie Y, Pausch M, Hayashi-Takagi A, Ishizuka K, ... ... Brandon NJ, et al. The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function. Molecular Psychiatry. 16: 1006-23. PMID 20838393 DOI: 10.1038/mp.2010.87  1
2011 Kelly MP, Brandon NJ. Taking a bird's eye view on a mouse model review: A comparison of findings from mouse models targeting DISC1 or DISC1-interacting proteins Future Neurology. 6: 661-677. DOI: 10.2217/fnl.11.39  1
2010 Brandon NJ. What happened when the environment met DISC1? Showing the interactive effects of poly I:C and DISC1 on mouse phenotypes related to mood disorders. Biological Psychiatry. 68: 1080-1. PMID 21130220 DOI: 10.1016/j.biopsych.2010.10.016  1
2010 Srivastava DP, Woolfrey KM, Liu F, Brandon NJ, Penzes P. Estrogen receptor ß activity modulates synaptic signaling and structure. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13454-60. PMID 20926671 DOI: 10.1523/JNEUROSCI.3264-10.2010  1
2010 Charych EI, Jiang LX, Lo F, Sullivan K, Brandon NJ. Interplay of palmitoylation and phosphorylation in the trafficking and localization of phosphodiesterase 10A: implications for the treatment of schizophrenia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9027-37. PMID 20610737 DOI: 10.1523/JNEUROSCI.1635-10.2010  1
2010 Hayashi MA, Guerreiro JR, Charych E, Kamiya A, Barbosa RL, Machado MF, Campeiro JD, Oliveira V, Sawa A, Camargo AC, Brandon NJ. Assessing the role of endooligopeptidase activity of Ndel1 (nuclear-distribution gene E homolog like-1) in neurite outgrowth. Molecular and Cellular Neurosciences. 44: 353-61. PMID 20462516 DOI: 10.1016/j.mcn.2010.04.006  1
2010 Höfgen N, Stange H, Schindler R, Lankau HJ, Grunwald C, Langen B, Egerland U, Tremmel P, Pangalos MN, Marquis KL, Hage T, Harrison BL, Malamas MS, Brandon NJ, Kronbach T. Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors. Journal of Medicinal Chemistry. 53: 4399-411. PMID 20450197 DOI: 10.1021/jm1002793  1
2010 Smith KR, Oliver PL, Lumb MJ, Arancibia-Carcamo IL, Revilla-Sanchez R, Brandon NJ, Moss SJ, Kittler JT. Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neurons. Molecular and Cellular Neurosciences. 44: 330-41. PMID 20417281 DOI: 10.1016/j.mcn.2010.04.004  1
2010 Kelly MP, Logue SF, Brennan J, Day JP, Lakkaraju S, Jiang L, Zhong X, Tam M, Sukoff Rizzo SJ, Platt BJ, Dwyer JM, Neal S, Pulito VL, Agostino MJ, Grauer SM, ... ... Brandon NJ, et al. Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes. Proceedings of the National Academy of Sciences of the United States of America. 107: 8457-62. PMID 20404172 DOI: 10.1073/pnas.1000730107  1
2010 Jurd R, Tretter V, Walker J, Brandon NJ, Moss SJ. Fyn kinase contributes to tyrosine phosphorylation of the GABA(A) receptor gamma2 subunit. Molecular and Cellular Neurosciences. 44: 129-34. PMID 20233604 DOI: 10.1016/j.mcn.2010.03.002  1
2010 Hayashi-Takagi A, Takaki M, Graziane N, Seshadri S, Murdoch H, Dunlop AJ, Makino Y, Seshadri AJ, Ishizuka K, Srivastava DP, Xie Z, Baraban JM, Houslay MD, Tomoda T, Brandon NJ, et al. Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1. Nature Neuroscience. 13: 327-32. PMID 20139976 DOI: 10.1038/nn.2487  1
2010 Srivastava DP, Woolfrey KM, Liu F, Brandon NJ, Penzes P. Estrogen receptor β activity modulates synaptic signaling and structure (The Journal of Neuroscience (2010) (13454-13460)) Journal of Neuroscience. 30.  1
2009 Kelly MP, Brandon NJ. Differential function of phosphodiesterase families in the brain: gaining insights through the use of genetically modified animals. Progress in Brain Research. 179: 67-73. PMID 20302819 DOI: 10.1016/S0079-6123(09)17908-6  1
2009 Hughes ZA, Liu F, Marquis K, Muniz L, Pangalos MN, Ring RH, Whiteside GT, Brandon NJ. Estrogen receptor neurobiology and its potential for translation into broad spectrum therapeutics for CNS disorders. Current Molecular Pharmacology. 2: 215-36. PMID 20021460 DOI: 10.2174/1874467210902030215  1
2009 Tretter V, Revilla-Sanchez R, Houston C, Terunuma M, Havekes R, Florian C, Jurd R, Vithlani M, Michels G, Couve A, Sieghart W, Brandon N, Abel T, Smart TG, Moss SJ. Deficits in spatial memory correlate with modified {gamma}-aminobutyric acid type A receptor tyrosine phosphorylation in the hippocampus. Proceedings of the National Academy of Sciences of the United States of America. 106: 20039-44. PMID 19903874 DOI: 10.1073/pnas.0908840106  1
2009 Kramár EA, Chen LY, Brandon NJ, Rex CS, Liu F, Gall CM, Lynch G. Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12982-93. PMID 19828812 DOI: 10.1523/JNEUROSCI.3059-09.2009  1
2009 Brandon NJ, Millar JK, Korth C, Sive H, Singh KK, Sawa A. Understanding the role of DISC1 in psychiatric disease and during normal development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12768-75. PMID 19828788 DOI: 10.1523/JNEUROSCI.3355-09.2009  1
2009 Logue SF, Grauer SM, Paulsen J, Graf R, Taylor N, Sung MA, Zhang L, Hughes Z, Pulito VL, Liu F, Rosenzweig-Lipson S, Brandon NJ, Marquis KL, Bates B, Pausch M. The orphan GPCR, GPR88, modulates function of the striatal dopamine system: a possible therapeutic target for psychiatric disorders? Molecular and Cellular Neurosciences. 42: 438-47. PMID 19796684 DOI: 10.1016/j.mcn.2009.09.007  1
2009 Jaaro-Peled H, Hayashi-Takagi A, Seshadri S, Kamiya A, Brandon NJ, Sawa A. Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1. Trends in Neurosciences. 32: 485-95. PMID 19712980 DOI: 10.1016/j.tins.2009.05.007  1
2009 Grauer SM, Pulito VL, Navarra RL, Kelly MP, Kelley C, Graf R, Langen B, Logue S, Brennan J, Jiang L, Charych E, Egerland U, Liu F, Marquis KL, Malamas M, ... ... Brandon NJ, et al. Phosphodiesterase 10A inhibitor activity in preclinical models of the positive, cognitive, and negative symptoms of schizophrenia. The Journal of Pharmacology and Experimental Therapeutics. 331: 574-90. PMID 19661377 DOI: 10.1124/jpet.109.155994  1
2009 Charych EI, Liu F, Moss SJ, Brandon NJ. GABA(A) receptors and their associated proteins: implications in the etiology and treatment of schizophrenia and related disorders. Neuropharmacology. 57: 481-95. PMID 19631671 DOI: 10.1016/j.neuropharm.2009.07.027  1
2009 Smith SM, Uslaner JM, Yao L, Mullins CM, Surles NO, Huszar SL, McNaughton CH, Pascarella DM, Kandebo M, Hinchliffe RM, Sparey T, Brandon NJ, Jones B, Venkatraman S, Young MB, et al. The behavioral and neurochemical effects of a novel D-amino acid oxidase inhibitor compound 8 [4H-thieno [3,2-b]pyrrole-5-carboxylic acid] and D-serine. The Journal of Pharmacology and Experimental Therapeutics. 328: 921-30. PMID 19088300 DOI: 10.1124/jpet.108.147884  1
2008 Shen S, Lang B, Nakamoto C, Zhang F, Pu J, Kuan SL, Chatzi C, He S, Mackie I, Brandon NJ, Marquis KL, Day M, Hurko O, McCaig CD, Riedel G, et al. Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 10893-904. PMID 18945897 DOI: 10.1523/JNEUROSCI.3299-08.2008  1
2008 Collins DM, Murdoch H, Dunlop AJ, Charych E, Baillie GS, Wang Q, Herberg FW, Brandon N, Prinz A, Houslay MD. Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA). Cellular Signalling. 20: 2356-69. PMID 18845247 DOI: 10.1016/j.cellsig.2008.09.017  1
2008 Liu F, Grauer S, Kelley C, Navarra R, Graf R, Zhang G, Atkinson PJ, Popiolek M, Wantuch C, Khawaja X, Smith D, Olsen M, Kouranova E, Lai M, Pruthi F, ... ... Brandon NJ, et al. ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities. The Journal of Pharmacology and Experimental Therapeutics. 327: 827-39. PMID 18753411 DOI: 10.1124/jpet.108.136580  1
2008 Camargo LM, Wang Q, Brandon NJ. What can we learn from the disrupted in schizophrenia 1 interactome: lessons for target identification and disease biology? Novartis Foundation Symposium. 289: 208-16; discussion 2. PMID 18497105  1
2008 Sparey T, Abeywickrema P, Almond S, Brandon N, Byrne N, Campbell A, Hutson PH, Jacobson M, Jones B, Munshi S, Pascarella D, Pike A, Prasad GS, Sachs N, Sakatis M, et al. The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 3386-91. PMID 18455394 DOI: 10.1016/j.bmcl.2008.04.020  1
2008 Burnet PW, Hutchinson L, von Hesling M, Gilbert EJ, Brandon NJ, Rutter AR, Hutson PH, Harrison PJ. Expression of D-serine and glycine transporters in the prefrontal cortex and cerebellum in schizophrenia. Schizophrenia Research. 102: 283-94. PMID 18400471 DOI: 10.1016/j.schres.2008.02.009  1
2008 Liu F, Day M, Muñiz LC, Bitran D, Arias R, Revilla-Sanchez R, Grauer S, Zhang G, Kelley C, Pulito V, Sung A, Mervis RF, Navarra R, Hirst WD, Reinhart PH, ... ... Brandon NJ, et al. Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory. Nature Neuroscience. 11: 334-43. PMID 18297067 DOI: 10.1038/nn2057  1
2008 Wang Q, Jaaro-Peled H, Sawa A, Brandon NJ. How has DISC1 enabled drug discovery? Molecular and Cellular Neurosciences. 37: 187-95. PMID 18055216 DOI: 10.1016/j.mcn.2007.10.006  1
2008 Bothwell M, Akil H, Malaspina D, Walsh F, Brandon NJ, Spedding M, Talmage DA, Chao M, Lu B, Kahn RS. Discussion Novartis Foundation Symposium. 289: 97-100.  1
2007 Brandon NJ. Dissecting DISC1 function through protein-protein interactions. Biochemical Society Transactions. 35: 1283-6. PMID 17956330 DOI: 10.1042/BST0351283  1
2007 Ishizuka K, Chen J, Taya S, Li W, Millar JK, Xu Y, Clapcote SJ, Hookway C, Morita M, Kamiya A, Tomoda T, Lipska BK, Roder JC, Pletnikov M, Porteous D, ... ... Brandon NJ, et al. Evidence that many of the DISC1 isoforms in C57BL/6J mice are also expressed in 129S6/SvEv mice. Molecular Psychiatry. 12: 897-9. PMID 17895924 DOI: 10.1038/  1
2007 Camargo LM, Collura V, Rain JC, Mizuguchi K, Hermjakob H, Kerrien S, Bonnert TP, Whiting PJ, Brandon NJ. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Molecular Psychiatry. 12: 74-86. PMID 17043677 DOI: 10.1038/  1
2007 Brandon NJ, Rotella DP. Chapter 1 Potential CNS Applications for Phosphodiesterase Enzyme Inhibitors Annual Reports in Medicinal Chemistry. 42: 3-12. DOI: 10.1016/S0065-7743(07)42001-2  1
2006 Porteous DJ, Thomson P, Brandon NJ, Millar JK. The genetics and biology of DISC1--an emerging role in psychosis and cognition. Biological Psychiatry. 60: 123-31. PMID 16843095 DOI: 10.1016/j.biopsych.2006.04.008  1
2006 Almond SL, Fradley RL, Armstrong EJ, Heavens RB, Rutter AR, Newman RJ, Chiu CS, Konno R, Hutson PH, Brandon NJ. Behavioral and biochemical characterization of a mutant mouse strain lacking D-amino acid oxidase activity and its implications for schizophrenia. Molecular and Cellular Neurosciences. 32: 324-34. PMID 16843004 DOI: 10.1016/j.mcn.2006.05.003  1
2006 Brandish PE, Chiu CS, Schneeweis J, Brandon NJ, Leech CL, Kornienko O, Scolnick EM, Strulovici B, Zheng W. A cell-based ultra-high-throughput screening assay for identifying inhibitors of D-amino acid oxidase. Journal of Biomolecular Screening. 11: 481-7. PMID 16760370 DOI: 10.1177/1087057106288181  1
2005 Millar JK, Pickard BS, Mackie S, James R, Christie S, Buchanan SR, Malloy MP, Chubb JE, Huston E, Baillie GS, Thomson PA, Hill EV, Brandon NJ, Rain JC, Camargo LM, et al. DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science (New York, N.Y.). 310: 1187-91. PMID 16293762 DOI: 10.1126/science.1112915  1
2005 Brandon NJ, Schurov I, Camargo LM, Handford EJ, Duran-Jimeniz B, Hunt P, Millar JK, Porteous DJ, Shearman MS, Whiting PJ. Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site. Molecular and Cellular Neurosciences. 28: 613-24. PMID 15797709 DOI: 10.1016/j.mcn.2004.11.003  1
2005 Hayashi MA, Portaro FC, Bastos MF, Guerreiro JR, Oliveira V, Gorrão SS, Tambourgi DV, Sant'Anna OA, Whiting PJ, Camargo LM, Konno K, Brandon NJ, Camargo AC. Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1. Proceedings of the National Academy of Sciences of the United States of America. 102: 3828-33. PMID 15728732 DOI: 10.1073/pnas.0500330102  1
2004 Millar JK, James R, Brandon NJ, Thomson PA. DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness. Annals of Medicine. 36: 367-78. PMID 15478311 DOI: 10.1080/07853890410033603  1
2004 Schurov IL, Handford EJ, Brandon NJ, Whiting PJ. Expression of disrupted in schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopment. Molecular Psychiatry. 9: 1100-10. PMID 15381924 DOI: 10.1038/  1
2004 Brandon NJ, Handford EJ, Schurov I, Rain JC, Pelling M, Duran-Jimeniz B, Camargo LM, Oliver KR, Beher D, Shearman MS, Whiting PJ. Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders. Molecular and Cellular Neurosciences. 25: 42-55. PMID 14962739 DOI: 10.1016/j.mcn.2003.09.009  1
2003 Brandon NJ, Jovanovic JN, Colledge M, Kittler JT, Brandon JM, Scott JD, Moss SJ. A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits. Molecular and Cellular Neurosciences. 22: 87-97. PMID 12595241 DOI: 10.1016/S1044-7431(02)00017-9  1
2002 Brandon N, Jovanovic J, Moss S. Multiple roles of protein kinases in the modulation of gamma-aminobutyric acid(A) receptor function and cell surface expression. Pharmacology & Therapeutics. 94: 113-22. PMID 12191597 DOI: 10.1016/S0163-7258(02)00175-4  1
2002 Brandon NJ, Jovanovic JN, Smart TG, Moss SJ. Receptor for activated C kinase-1 facilitates protein kinase C-dependent phosphorylation and functional modulation of GABA(A) receptors with the activation of G-protein-coupled receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 6353-61. PMID 12151513  1
2001 Brandon NJ, Delmas P, Hill J, Smart TG, Moss SJ. Constitutive tyrosine phosphorylation of the GABA(A) receptor gamma 2 subunit in rat brain. Neuropharmacology. 41: 745-52. PMID 11640929 DOI: 10.1016/S0028-3908(01)00121-6  1
2000 Brandon NJ, Moss SJ. Receptor cross talk: ligand-gated ion channels start to communicate. Science's Stke : Signal Transduction Knowledge Environment. 2000: pe1. PMID 11752615 DOI: 10.1126/stke.2000.55.pe1  1
2000 Brandon NJ, Delmas P, Kittler JT, McDonald BJ, Sieghart W, Brown DA, Smart TG, Moss SJ. GABAA receptor phosphorylation and functional modulation in cortical neurons by a protein kinase C-dependent pathway. The Journal of Biological Chemistry. 275: 38856-62. PMID 10978327 DOI: 10.1074/jbc.M004910200  1
1999 Brandon NJ, Bedford FK, Connolly CN, Couve A, Kittler JT, Hanley JG, Jovanovic JN, Uren J, Taylor P, Thomas P, Smart TG, Moss SJ. Synaptic targeting and regulation of GABA(A) receptors. Biochemical Society Transactions. 27: 527-30. PMID 10917634  1
1999 Connolly CN, Kittler JT, Thomas P, Uren JM, Brandon NJ, Smart TG, Moss SJ. Cell surface stability of gamma-aminobutyric acid type A receptors. Dependence on protein kinase C activity and subunit composition. The Journal of Biological Chemistry. 274: 36565-72. PMID 10593956 DOI: 10.1074/jbc.274.51.36565  1
1999 Brandon NJ, Uren JM, Kittler JT, Wang H, Olsen R, Parker PJ, Moss SJ. Subunit-specific association of protein kinase C and the receptor for activated C kinase with GABA type A receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 9228-34. PMID 10531426  1
1999 Wang H, Bedford FK, Brandon NJ, Moss SJ, Olsen RW. GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton. Nature. 397: 69-72. PMID 9892355 DOI: 10.1038/16264  1
1998 Read EM, Rodaway AR, Neave B, Brandon N, Holder N, Patient RK, Walmsley ME. Evidence for non-axial A/P patterning in the nonneural ectoderm of Xenopus and zebrafish pregastrula embryos. The International Journal of Developmental Biology. 42: 763-74. PMID 9727832  1
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