Nick Brandon - Publications

AstraZeneca LP, Canóvanas, Canóvanas, Puerto Rico 
Schizophrenia and Bioplar disorder

51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Erli F, Palmos AB, Raval P, Mukherjee J, Sellers KJ, Gatford NJF, Moss SJ, Brandon NJ, Penzes P, Srivastava DP. Estradiol reverses excitatory synapse loss in a cellular model of neuropsychiatric disorders. Translational Psychiatry. 10: 16. PMID 32066698 DOI: 10.1038/S41398-020-0682-4  0.63
2019 Chadchankar J, Korboukh V, Conway LC, Wobst HJ, Walker CA, Doig P, Jacobsen SJ, Brandon NJ, Moss SJ, Wang Q. Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells. Plos One. 14: e0225145. PMID 31703099 DOI: 10.1371/journal.pone.0225145  0.435
2019 Moore YE, Conway LC, Wobst HJ, Brandon NJ, Deeb TZ, Moss SJ. Developmental Regulation of KCC2 Phosphorylation Has Long-Term Impacts on Cognitive Function. Frontiers in Molecular Neuroscience. 12: 173. PMID 31396048 DOI: 10.3389/fnmol.2019.00173  0.588
2019 Nathanson AJ, Zhang Y, Smalley JL, Ollerhead TA, Rodriguez Santos MA, Andrews PM, Wobst HJ, Moore YE, Brandon NJ, Hines RM, Davies PA, Moss SJ. Identification of a Core Amino Acid Motif within the α Subunit of GABARs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures. Cell Reports. 28: 670-681.e8. PMID 31315046 DOI: 10.1016/J.Celrep.2019.06.014  0.77
2019 Huyghe D, Denninger AR, Voss CM, Frank P, Gao N, Brandon N, Waagepetersen HS, Ferguson AD, Pangalos M, Doig P, Moss SJ. Phosphorylation of Glutamine Synthetase on Threonine 301 Contributes to Its Inactivation During Epilepsy. Frontiers in Molecular Neuroscience. 12: 120. PMID 31178690 DOI: 10.3389/Fnmol.2019.00120  0.478
2019 Read J, Collie IT, Nguyen-McCarty M, Lucaj C, Robinson J, Conway L, Mukherjee J, McCall E, Donohoe G, Flavell E, Peciak K, Warwicker J, Dix C, Van den Hoven BG, Madin A, ... ... Brandon NJ, et al. Tool inhibitors and assays to interrogate the biology of the TRAF2 and NCK interacting kinase. Bioorganic & Medicinal Chemistry Letters. PMID 31153805 DOI: 10.1016/J.Bmcl.2019.05.032  0.59
2018 Moore YE, Deeb TZ, Chadchankar H, Brandon NJ, Moss SJ. Potentiating KCC2 activity is sufficient to limit the onset and severity of seizures. Proceedings of the National Academy of Sciences of the United States of America. PMID 30224498 DOI: 10.1073/Pnas.1810134115  0.567
2018 Hines RM, Maric HM, Hines DJ, Modgil A, Panzanelli P, Nakamura Y, Nathanson AJ, Cross A, Deeb T, Brandon NJ, Davies P, Fritschy JM, Schindelin H, Moss SJ. Developmental seizures and mortality result from reducing GABA receptor α2-subunit interaction with collybistin. Nature Communications. 9: 3130. PMID 30087324 DOI: 10.1038/S41467-018-05481-1  0.78
2018 Kelley MR, Cardarelli RA, Smalley JL, Ollerhead TA, Andrew PM, Brandon NJ, Deeb TZ, Moss SJ. Locally Reducing KCC2 Activity in the Hippocampus is Sufficient to Induce Temporal Lobe Epilepsy. Ebiomedicine. PMID 29884458 DOI: 10.1016/j.ebiom.2018.05.029  0.725
2018 Fan J, Zhao RQ, Parro C, Zhao W, Chou HY, Robert J, Deeb TZ, Raynoschek C, Barichievy S, Engvist O, Maresca M, Hicks R, Meuller J, Moss SJ, Brandon NJ, et al. Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway. Journal of Lipid Research. PMID 29563219 DOI: 10.1194/jlr.M081851  0.461
2017 Cardarelli RA, Jones K, Pisella LI, Wobst HJ, McWilliams LJ, Sharpe PM, Burnham MP, Baker DJ, Chudotvorova I, Guyot J, Silayeva L, Morrow DH, Dekker N, Zicha S, Davies PA, ... ... Brandon NJ, et al. The small molecule CLP257 does not modify activity of the K+-Cl- co-transporter KCC2 but does potentiate GABAA receptor activity. Nature Medicine. 23: 1394-1396. PMID 29216042 DOI: 10.1038/nm.4442  0.642
2017 Agez M, Schultz P, Medina I, Baker DJ, Burnham MP, Cardarelli RA, Conway LC, Garnier K, Geschwindner S, Gunnarsson A, McCall EJ, Frechard A, Audebert S, Deeb TZ, Moss SJ, ... Brandon NJ, et al. Molecular architecture of potassium chloride co-transporter KCC2. Scientific Reports. 7: 16452. PMID 29184062 DOI: 10.1038/s41598-017-15739-1  0.646
2017 Conway LC, Cardarelli RA, Moore YE, Jones K, McWilliams LJ, Baker DJ, Burnham MP, Bürli RW, Wang Q, Brandon NJ, Moss SJ, Deeb TZ. N-ethylmaleimide increases KCC2 activity by modulating transporter phosphorylation. The Journal of Biological Chemistry. PMID 29092909 DOI: 10.1074/jbc.M117.817841  0.694
2017 Mukherjee J, Cardarelli RA, Cantaut-Belarif Y, Deeb TZ, Srivastava DP, Tyagarajan SK, Pangalos MN, Triller A, Maguire J, Brandon NJ, Moss SJ. Estradiol modulates the efficacy of synaptic inhibition by decreasing the dwell time of GABAA receptors at inhibitory synapses. Proceedings of the National Academy of Sciences of the United States of America. PMID 29078280 DOI: 10.1073/Pnas.1705075114  0.764
2017 Moore YE, Kelley MR, Brandon NJ, Deeb TZ, Moss SJ. Seizing Control of KCC2: A New Therapeutic Target for Epilepsy. Trends in Neurosciences. PMID 28803659 DOI: 10.1016/j.tins.2017.06.008  0.68
2017 Wobst HJ, Delsing L, Brandon NJ, Moss SJ. Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant. Plos One. 12: e0177181. PMID 28510586 DOI: 10.1371/journal.pone.0177181  0.398
2017 Wobst HJ, Wesolowski SS, Chadchankar J, Delsing L, Jacobsen S, Mukherjee J, Deeb TZ, Dunlop J, Brandon NJ, Moss SJ. Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro. Frontiers in Molecular Neuroscience. 10: 46. PMID 28286471 DOI: 10.3389/fnmol.2017.00046  0.553
2017 Kang JY, Chadchankar J, Vien TN, Mighdoll MI, Hyde TM, Mather RJ, Deeb TZ, Pangalos MN, Brandon NJ, Dunlop J, Moss SJ. Deficits in the activity of presynaptic γ-Aminobutyric acid type B receptors contribute to altered neuronal excitability in Fragile X Syndrome. The Journal of Biological Chemistry. PMID 28213518 DOI: 10.1074/jbc.M116.772541  0.6
2016 Kelley MR, Deeb TZ, Brandon NJ, Dunlop J, Davies PA, Moss SJ. Compromising KCC2 transporter activity enhances the development of continuous seizure activity. Neuropharmacology. PMID 27108931 DOI: 10.1016/j.neuropharm.2016.04.029  0.662
2016 Diggle CP, Sukoff Rizzo SJ, Popiolek M, Hinttala R, Schülke JP, Kurian MA, Carr IM, Markham AF, Bonthron DT, Watson C, Sharif SM, Reinhart V, James LC, Vanase-Frawley MA, Charych E, ... ... Brandon NJ, et al. Biallelic Mutations in PDE10A Lead to Loss of Striatal PDE10A and a Hyperkinetic Movement Disorder with Onset in Infancy. American Journal of Human Genetics. 98: 735-43. PMID 27058446 DOI: 10.1016/J.Ajhg.2016.03.015  0.648
2016 Saito A, Taniguchi Y, Rannals MD, Merfeld EB, Ballinger MD, Koga M, Ohtani Y, Gurley DA, Sedlak TW, Cross A, Moss SJ, Brandon NJ, Maher BJ, Kamiya A. Early postnatal GABAA receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1. Molecular Psychiatry. PMID 26728564 DOI: 10.1038/Mp.2015.203  0.615
2015 Vien TN, Modgil A, Abramian AM, Jurd R, Walker J, Brandon NJ, Terunuma M, Rudolph U, Maguire J, Davies PA, Moss SJ. Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disorders. Proceedings of the National Academy of Sciences of the United States of America. 112: 14805-10. PMID 26627235 DOI: 10.1073/Pnas.1514657112  0.767
2015 Sivakumaran S, Cardarelli RA, Maguire J, Kelley MR, Silayeva L, Morrow DH, Mukherjee J, Moore YE, Mather RJ, Duggan ME, Brandon NJ, Dunlop J, Zicha S, Moss SJ, Deeb TZ. Selective Inhibition of KCC2 Leads to Hyperexcitability and Epileptiform Discharges in Hippocampal Slices and In Vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 8291-6. PMID 26019342 DOI: 10.1523/Jneurosci.5205-14.2015  0.812
2015 Silayeva L, Deeb TZ, Hines RM, Kelley MR, Munoz MB, Lee HH, Brandon NJ, Dunlop J, Maguire J, Davies PA, Moss SJ. KCC2 activity is critical in limiting the onset and severity of status epilepticus. Proceedings of the National Academy of Sciences of the United States of America. 112: 3523-8. PMID 25733865 DOI: 10.1073/Pnas.1415126112  0.807
2014 Wei J, Graziane NM, Wang H, Zhong P, Wang Q, Liu W, Hayashi-Takagi A, Korth C, Sawa A, Brandon NJ, Yan Z. Regulation of N-methyl-D-aspartate receptors by disrupted-in-schizophrenia-1. Biological Psychiatry. 75: 414-24. PMID 23906531 DOI: 10.1016/J.Biopsych.2013.06.009  0.3
2013 Vithlani M, Hines RM, Zhong P, Terunuma M, Hines DJ, Revilla-Sanchez R, Jurd R, Haydon P, Rios M, Brandon N, Yan Z, Moss SJ. The ability of BDNF to modify neurogenesis and depressive-like behaviors is dependent upon phosphorylation of tyrosine residues 365/367 in the GABA(A)-receptor γ2 subunit. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 15567-77. PMID 24068823 DOI: 10.1523/Jneurosci.1845-13.2013  0.782
2012 Sukoff Rizzo SJ, Neal SJ, Hughes ZA, Beyna M, Rosenzweig-Lipson S, Moss SJ, Brandon NJ. Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes. Translational Psychiatry. 2: e199. PMID 23212583 DOI: 10.1038/tp.2012.120  0.683
2012 Atkin TA, Brandon NJ, Kittler JT. Disrupted in Schizophrenia 1 forms pathological aggresomes that disrupt its function in intracellular transport. Human Molecular Genetics. 21: 2017-28. PMID 22291444 DOI: 10.1093/hmg/dds018  0.556
2011 Popiolek M, Ross JF, Charych E, Chanda P, Gundelfinger ED, Moss SJ, Brandon NJ, Pausch MH. D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone. The Journal of Biological Chemistry. 286: 28867-75. PMID 21700703 DOI: 10.1074/Jbc.M111.262063  0.504
2011 Atkin TA, MacAskill AF, Brandon NJ, Kittler JT. Disrupted in Schizophrenia-1 regulates intracellular trafficking of mitochondria in neurons. Molecular Psychiatry. 16: 122-4, 121. PMID 21079610 DOI: 10.1038/mp.2010.110  0.538
2011 Wang Q, Charych EI, Pulito VL, Lee JB, Graziane NM, Crozier RA, Revilla-Sanchez R, Kelly MP, Dunlop AJ, Murdoch H, Taylor N, Xie Y, Pausch M, Hayashi-Takagi A, Ishizuka K, ... ... Brandon NJ, et al. The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function. Molecular Psychiatry. 16: 1006-23. PMID 20838393 DOI: 10.1038/Mp.2010.87  0.79
2011 Atkin TA, MacAskill AF, Brandon NJ, Kittler JT. The DISC1Cys607Phe polymorphism affects mitochondrial transport in neurons Molecular Psychiatry. 16: 121-121. DOI: 10.1038/mp.2010.135  0.521
2010 Srivastava DP, Woolfrey KM, Liu F, Brandon NJ, Penzes P. Estrogen receptor ß activity modulates synaptic signaling and structure. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13454-60. PMID 20926671 DOI: 10.1523/Jneurosci.3264-10.2010  0.334
2010 Smith KR, Oliver PL, Lumb MJ, Arancibia-Carcamo IL, Revilla-Sanchez R, Brandon NJ, Moss SJ, Kittler JT. Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neurons. Molecular and Cellular Neurosciences. 44: 330-41. PMID 20417281 DOI: 10.1016/J.Mcn.2010.04.004  0.832
2010 Kelly MP, Logue SF, Brennan J, Day JP, Lakkaraju S, Jiang L, Zhong X, Tam M, Sukoff Rizzo SJ, Platt BJ, Dwyer JM, Neal S, Pulito VL, Agostino MJ, Grauer SM, ... ... Brandon NJ, et al. Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes. Proceedings of the National Academy of Sciences of the United States of America. 107: 8457-62. PMID 20404172 DOI: 10.1073/Pnas.1000730107  0.707
2010 Jurd R, Tretter V, Walker J, Brandon NJ, Moss SJ. Fyn kinase contributes to tyrosine phosphorylation of the GABA(A) receptor gamma2 subunit. Molecular and Cellular Neurosciences. 44: 129-34. PMID 20233604 DOI: 10.1016/j.mcn.2010.03.002  0.845
2009 Tretter V, Revilla-Sanchez R, Houston C, Terunuma M, Havekes R, Florian C, Jurd R, Vithlani M, Michels G, Couve A, Sieghart W, Brandon N, Abel T, Smart TG, Moss SJ. Deficits in spatial memory correlate with modified {gamma}-aminobutyric acid type A receptor tyrosine phosphorylation in the hippocampus. Proceedings of the National Academy of Sciences of the United States of America. 106: 20039-44. PMID 19903874 DOI: 10.1073/Pnas.0908840106  0.781
2009 Kramár EA, Chen LY, Brandon NJ, Rex CS, Liu F, Gall CM, Lynch G. Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12982-93. PMID 19828812 DOI: 10.1523/Jneurosci.3059-09.2009  0.32
2009 Charych EI, Liu F, Moss SJ, Brandon NJ. GABA(A) receptors and their associated proteins: implications in the etiology and treatment of schizophrenia and related disorders. Neuropharmacology. 57: 481-95. PMID 19631671 DOI: 10.1016/j.neuropharm.2009.07.027  0.634
2008 Liu F, Day M, Muñiz LC, Bitran D, Arias R, Revilla-Sanchez R, Grauer S, Zhang G, Kelley C, Pulito V, Sung A, Mervis RF, Navarra R, Hirst WD, Reinhart PH, ... ... Brandon NJ, et al. Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory. Nature Neuroscience. 11: 334-43. PMID 18297067 DOI: 10.1038/Nn2057  0.822
2003 Brandon NJ, Jovanovic JN, Colledge M, Kittler JT, Brandon JM, Scott JD, Moss SJ. A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits. Molecular and Cellular Neurosciences. 22: 87-97. PMID 12595241 DOI: 10.1016/S1044-7431(02)00017-9  0.818
2002 Brandon N, Jovanovic J, Moss S. Multiple roles of protein kinases in the modulation of gamma-aminobutyric acid(A) receptor function and cell surface expression. Pharmacology & Therapeutics. 94: 113-22. PMID 12191597 DOI: 10.1016/S0163-7258(02)00175-4  0.857
2002 Brandon NJ, Jovanovic JN, Smart TG, Moss SJ. Receptor for activated C kinase-1 facilitates protein kinase C-dependent phosphorylation and functional modulation of GABA(A) receptors with the activation of G-protein-coupled receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 6353-61. PMID 12151513 DOI: 10.1523/Jneurosci.22-15-06353.2002  0.847
2001 Brandon NJ, Delmas P, Hill J, Smart TG, Moss SJ. Constitutive tyrosine phosphorylation of the GABA(A) receptor gamma 2 subunit in rat brain. Neuropharmacology. 41: 745-52. PMID 11640929 DOI: 10.1016/S0028-3908(01)00121-6  0.658
2000 Brandon NJ, Moss SJ. Receptor cross talk: ligand-gated ion channels start to communicate. Science's Stke : Signal Transduction Knowledge Environment. 2000: pe1. PMID 11752615 DOI: 10.1126/stke.2000.55.pe1  0.523
2000 Brandon NJ, Delmas P, Kittler JT, McDonald BJ, Sieghart W, Brown DA, Smart TG, Moss SJ. GABAA receptor phosphorylation and functional modulation in cortical neurons by a protein kinase C-dependent pathway. The Journal of Biological Chemistry. 275: 38856-62. PMID 10978327 DOI: 10.1074/Jbc.M004910200  0.798
1999 Brandon NJ, Bedford FK, Connolly CN, Couve A, Kittler JT, Hanley JG, Jovanovic JN, Uren J, Taylor P, Thomas P, Smart TG, Moss SJ. Synaptic targeting and regulation of GABA(A) receptors. Biochemical Society Transactions. 27: 527-30. PMID 10917634 DOI: 10.1042/Bst0270527  0.79
1999 Connolly CN, Kittler JT, Thomas P, Uren JM, Brandon NJ, Smart TG, Moss SJ. Cell surface stability of gamma-aminobutyric acid type A receptors. Dependence on protein kinase C activity and subunit composition. The Journal of Biological Chemistry. 274: 36565-72. PMID 10593956 DOI: 10.1074/Jbc.274.51.36565  0.819
1999 Brandon NJ, Uren JM, Kittler JT, Wang H, Olsen R, Parker PJ, Moss SJ. Subunit-specific association of protein kinase C and the receptor for activated C kinase with GABA type A receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 9228-34. PMID 10531426 DOI: 10.1523/Jneurosci.19-21-09228.1999  0.763
1999 Wang H, Bedford FK, Brandon NJ, Moss SJ, Olsen RW. GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton. Nature. 397: 69-72. PMID 9892355 DOI: 10.1038/16264  0.79
1999 Bedford F, Brandon NJ, Connolly C, Kittler J, Hanley J, Jovanovic J, Smart JUT, Moss S. Synaptic targeting and regulation of Ionotropic GABA receptors Biochemical Society Transactions. 27: A70-A70. DOI: 10.1042/Bst027A070B  0.826
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