Clemens Scherzer - Publications

Affiliations: 
Harvard Medical School, Boston, MA, United States 
Area:
Translational Genomics of Parkinson’s Disease: Cause, Cures, Diagnostics

55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Karayel O, Virreira Winter S, Padmanabhan S, Kuras YI, Vu DT, Tuncali I, Merchant K, Wills AM, Scherzer CR, Mann M. Proteome profiling of cerebrospinal fluid reveals biomarker candidates for Parkinson's disease. Cell Reports. Medicine. 3: 100661. PMID 35732154 DOI: 10.1016/j.xcrm.2022.100661  0.3
2022 Bivol S, Mellick GD, Gratten J, Parker R, Mulcahy A, Mosley PE, Poortvliet PC, Campos AI, Mitchell BL, Garcia-Marin LM, Cross S, Ferguson M, Lind PA, Loesch DZ, Visscher PM, ... ... Scherzer CR, et al. Australian Parkinson's Genetics Study (APGS): pilot (n=1532). Bmj Open. 12: e052032. PMID 35217535 DOI: 10.1136/bmjopen-2021-052032  0.371
2022 Szwedo AA, Dalen I, Pedersen KF, Camacho M, Bäckström D, Forsgren L, Tzoulis C, Winder-Rhodes S, Hudson G, Liu G, Scherzer CR, Lawson RA, Yarnall AJ, Williams-Gray CH, Macleod AD, et al. GBA and APOE Impact Cognitive Decline in Parkinson's Disease: A 10-Year Population-Based Study. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 35106798 DOI: 10.1002/mds.28932  0.345
2021 Peterschmitt MJ, Saiki H, Hatano T, Gasser T, Isaacson SH, Gaemers SJM, Minini P, Saubadu S, Sharma J, Walbillic S, Alcalay RN, Cutter G, Hattori N, Höglinger GU, Marek K, ... ... Scherzer CR, et al. Safety, Pharmacokinetics, and Pharmacodynamics of Oral Venglustat in Patients with Parkinson's Disease and a GBA Mutation: Results from Part 1 of the Randomized, Double-Blinded, Placebo-Controlled MOVES-PD Trial. Journal of Parkinson's Disease. PMID 34897099 DOI: 10.3233/JPD-212714  0.32
2021 Huh YE, Park H, Chiang MSR, Tuncali I, Liu G, Locascio JJ, Shirvan J, Hutten SJ, Rotunno MS, Viel C, Shihabuddin LS, Wang B, Sardi SP, Scherzer CR. Glucosylceramide in cerebrospinal fluid of patients with GBA-associated and idiopathic Parkinson's disease enrolled in PPMI. Npj Parkinson's Disease. 7: 102. PMID 34811369 DOI: 10.1038/s41531-021-00241-3  0.327
2021 Domínguez-Baleón C, Ong JS, Scherzer CR, Rentería ME, Dong X. Understanding the effect of smoking and drinking behavior on Parkinson's disease risk: a Mendelian randomization study. Scientific Reports. 11: 13980. PMID 34234189 DOI: 10.1038/s41598-021-93105-y  0.658
2021 Dong X, Li X, Chang TW, Scherzer CR, Weiss ST, Qiu W. powerEQTL: An R package and shiny application for sample size and power calculation of bulk tissue and single-cell eQTL analysis. Bioinformatics (Oxford, England). PMID 34009297 DOI: 10.1093/bioinformatics/btab385  0.628
2021 Iwaki H, Leonard HL, Makarious MB, Bookman M, Landin B, Vismer D, Casey B, Gibbs JR, Hernandez DG, Blauwendraat C, Vitale D, Song Y, Kumar D, Dalgard CL, Sadeghi M, ... ... Scherzer CR, et al. Accelerating Medicines Partnership: Parkinson's Disease. Genetic Resource. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33960523 DOI: 10.1002/mds.28549  0.662
2021 Liu G, Peng J, Liao Z, Locascio JJ, Corvol JC, Zhu F, Dong X, Maple-Grødem J, Campbell MC, Elbaz A, Lesage S, Brice A, Mangone G, Growdon JH, Hung AY, ... ... Scherzer CR, et al. Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson's disease. Nature Genetics. PMID 33958783 DOI: 10.1038/s41588-021-00847-6  0.692
2021 Ortega RA, Wang C, Raymond D, Bryant N, Scherzer CR, Thaler A, Alcalay RN, West AB, Mirelman A, Kuras Y, Marder KS, Giladi N, Ozelius LJ, Bressman SB, Saunders-Pullman R. Association of Dual LRRK2 G2019S and GBA Variations With Parkinson Disease Progression. Jama Network Open. 4: e215845. PMID 33881531 DOI: 10.1001/jamanetworkopen.2021.5845  0.355
2021 Lerche S, Schulte C, Wurster I, Machetanz G, Roeben B, Zimmermann M, Deuschle C, Hauser AK, Böhringer J, Krägeloh-Mann I, Waniek K, Lachmann I, Petterson XT, Chiang R, Park H, ... ... Scherzer CR, et al. The Mutation Matters: CSF Profiles of GCase, Sphingolipids, α-Synuclein in PD. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33547828 DOI: 10.1002/mds.28472  0.313
2021 Anderson FL, von Herrmann KM, Andrew AS, Kuras YI, Young AL, Scherzer CR, Hickey WF, Lee SL, Havrda MC. Plasma-borne indicators of inflammasome activity in Parkinson's disease patients. Npj Parkinson's Disease. 7: 2. PMID 33398042 DOI: 10.1038/s41531-020-00147-6  0.309
2020 Iwaki H, Blauwendraat C, Leonard HL, Makarious MB, Kim JJ, Liu G, Maple-Grødem J, Corvol JC, Pihlstrøm L, van Nimwegen M, Smolensky L, Amondikar N, Hutten SJ, Frasier M, Nguyen KH, ... ... Scherzer CR, et al. Differences in the Presentation and Progression of Parkinson's Disease by Sex. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33002231 DOI: 10.1002/mds.28312  0.357
2020 Alcalay RN, Wolf P, Chiang MSR, Helesicova K, Zhang XK, Merchant K, Hutten SJ, Scherzer C, Caspell-Garcia C, Blauwendraat C, Foroud T, Nudelman K, Gan-Or Z, Simuni T, Chahine LM, et al. Longitudinal Measurements of Glucocerebrosidase activity in Parkinson's patients. Annals of Clinical and Translational Neurology. PMID 32888397 DOI: 10.1002/Acn3.51164  0.454
2020 Ihle J, Artaud F, Bekadar S, Mangone G, Sambin S, Mariani LL, Bertrand H, Rascol O, Durif F, Derkinderen P, Scherzer C, Elbaz A, Corvol JC, Corvol JC, et al. Parkinson's disease polygenic risk score is not associated with impulse control disorders: A longitudinal study. Parkinsonism & Related Disorders. 75: 30-33. PMID 32450545 DOI: 10.1016/J.Parkreldis.2020.03.017  0.436
2020 Stoker TB, Camacho M, Winder-Rhodes S, Liu G, Scherzer CR, Foltynie T, Evans J, Breen DP, Barker RA, Williams-Gray CH. Impact of variants on long-term clinical progression and mortality in incident Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 32303560 DOI: 10.1136/jnnp-2020-322857  0.349
2020 Bakshi R, Macklin EA, Hung AY, Hayes MT, Hyman BT, Wills AM, Gomperts SN, Growdon JH, Ascherio A, Scherzer CR, Schwarzschild MA. Associations of Lower Caffeine Intake and Plasma Urate Levels with Idiopathic Parkinson's Disease in the Harvard Biomarkers Study. Journal of Parkinson's Disease. 10: 505-510. PMID 32250320 DOI: 10.3233/Jpd-191882  0.305
2020 Rotunno MS, Lane M, Zhang W, Wolf P, Oliva P, Viel C, Wills AM, Alcalay RN, Scherzer CR, Shihabuddin LS, Zhang K, Sardi SP. Cerebrospinal fluid proteomics implicates the granin family in Parkinson's disease. Scientific Reports. 10: 2479. PMID 32051502 DOI: 10.1038/S41598-020-59414-4  0.327
2019 Iwaki H, Blauwendraat C, Leonard HL, Kim JJ, Liu G, Maple-Grødem J, Corvol JC, Pihlstrøm L, van Nimwegen M, Hutten SJ, Nguyen KH, Rick J, Eberly S, Faghri F, Auinger P, ... ... Scherzer CR, et al. Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 31505070 DOI: 10.1002/Mds.27845  0.389
2019 Iwaki H, Blauwendraat C, Leonard HL, Liu G, Maple-Grødem J, Corvol JC, Pihlstrøm L, van Nimwegen M, Hutten SJ, Nguyen KH, Rick J, Eberly S, Faghri F, Auinger P, Scott KM, ... ... Scherzer CR, et al. Genetic risk of Parkinson disease and progression:: An analysis of 13 longitudinal cohorts. Neurology. Genetics. 5: e348. PMID 31404238 DOI: 10.1212/Nxg.0000000000000348  0.346
2019 O'Bryant SE, Edwards M, Zhang F, Johnson LA, Hall J, Kuras Y, Scherzer CR. Potential two-step proteomic signature for Parkinson's disease: Pilot analysis in the Harvard Biomarkers Study. Alzheimer's & Dementia (Amsterdam, Netherlands). 11: 374-382. PMID 31080873 DOI: 10.1016/J.Dadm.2019.03.001  0.378
2019 Henderson-Smith A, Fisch KM, Hua J, Liu G, Ricciardelli E, Jepsen K, Huentelman M, Stalberg G, Edland SD, Scherzer CR, Dunckley T, Desplats P. DNA methylation changes associated with Parkinson's disease progression: outcomes from the first longitudinal genome-wide methylation analysis in blood. Epigenetics. 1-18. PMID 30871403 DOI: 10.1080/15592294.2019.1588682  0.346
2018 Dong X, Liao Z, Gritsch D, Hadzhiev Y, Bai Y, Locascio JJ, Guennewig B, Liu G, Blauwendraat C, Wang T, Adler CH, Hedreen JC, Faull RLM, Frosch MP, Nelson PT, ... ... Scherzer CR, et al. Publisher Correction: Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease. Nature Neuroscience. PMID 30482917 DOI: 10.1038/S41593-018-0277-Z  0.641
2018 Dong X, Liao Z, Gritsch D, Hadzhiev Y, Bai Y, Locascio JJ, Guennewig B, Liu G, Blauwendraat C, Wang T, Adler CH, Hedreen JC, Faull RLM, Frosch MP, Nelson PT, ... ... Scherzer CR, et al. Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease. Nature Neuroscience. PMID 30224808 DOI: 10.1038/S41593-018-0223-0  0.675
2018 Chen-Plotkin AS, Albin R, Alcalay R, Babcock D, Bajaj V, Bowman D, Buko A, Cedarbaum J, Chelsky D, Cookson MR, Dawson TM, Dewey R, Foroud T, Frasier M, German D, ... ... Scherzer CR, et al. Finding useful biomarkers for Parkinson's disease. Science Translational Medicine. 10. PMID 30111645 DOI: 10.1126/Scitranslmed.Aam6003  0.319
2017 Mittal S, Bjørnevik K, Im DS, Flierl A, Dong X, Locascio JJ, Abo KM, Long E, Jin M, Xu B, Xiang YK, Rochet JC, Engeland A, Rizzu P, Heutink P, ... ... Scherzer CR, et al. β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson's disease. Science (New York, N.Y.). 357: 891-898. PMID 28860381 DOI: 10.1126/Science.Aaf3934  0.668
2017 Gwinn K, David KK, Swanson-Fischer C, Albin R, Hillaire-Clarke CS, Sieber BA, Lungu C, Bowman FD, Alcalay RN, Babcock D, Dawson TM, Dewey RB, Foroud T, German D, Huang X, ... ... Scherzer CR, et al. Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program. Biomarkers in Medicine. PMID 28644039 DOI: 10.2217/Bmm-2016-0370  0.342
2017 Liu G, Locascio JJ, Corvol JC, Boot B, Liao Z, Page K, Franco D, Burke K, Jansen IE, Trisini-Lipsanopoulos A, Winder-Rhodes S, Tanner CM, Lang AE, Eberly S, Elbaz A, ... ... Scherzer CR, et al. Prediction of cognition in Parkinson's disease with a clinical-genetic score: a longitudinal analysis of nine cohorts. The Lancet. Neurology. PMID 28629879 DOI: 10.1016/S1474-4422(17)30122-9  0.4
2017 Manocha GD, Floden AM, Puig KL, Nagamoto-Combs K, Scherzer CR, Combs CK. Defining the contribution of neuroinflammation to Parkinson's disease in humanized immune system mice. Molecular Neurodegeneration. 12: 17. PMID 28196514 DOI: 10.1186/S13024-017-0158-Z  0.317
2016 Schwarzschild M, Fitzgerald K, Bakshi R, Macklin E, Scherzer C, Ascherio A. Association of α-synuclein gene expression with Parkinson’s disease is attenuated with higher serum urate in the PPMI cohort Parkinsonism & Related Disorders. 22: e115. DOI: 10.1016/J.Parkreldis.2015.10.265  0.363
2015 Rosenthal LS, Drake D, Alcalay RN, Babcock D, Bowman FD, Chen-Plotkin A, Dawson TM, Dewey RB, German DC, Huang X, Landin B, McAuliffe M, Petyuk VA, Scherzer CR, Hillaire-Clarke CS, et al. The NINDS Parkinson's disease biomarkers program. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 26442452 DOI: 10.1002/Mds.26438  0.327
2015 Locascio JJ, Eberly S, Liao Z, Liu G, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Dhima K, Hung AY, Flaherty AW, Schwarzschild MA, Hayes MT, Wills AM, Shivraj Sohur U, Mejia NI, ... ... Scherzer CR, et al. Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease. Brain : a Journal of Neurology. 138: 2659-71. PMID 26220939 DOI: 10.1093/Brain/Awv202  0.695
2015 Locascio JJ, Eberly S, Liao Z, Liu G, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Dhima K, Hung AY, Flaherty AW, Schwarzschild MA, Hayes MT, Wills AM, Shivraj Sohur U, Mejia NI, ... ... Scherzer CR, et al. Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease Brain. 138: 2659-2671. DOI: 10.1093/brain/awv202  0.319
2014 Santiago JA, Scherzer CR, Potashkin JA. Network analysis identifies SOD2 mRNA as a potential biomarker for Parkinson's disease. Plos One. 9: e109042. PMID 25279756 DOI: 10.1371/journal.pone.0109042  0.327
2014 Ziegler DA, Ashourian P, Wonderlick JS, Sarokhan AK, Prelec D, Scherzer CR, Corkin S. Motor impulsivity in Parkinson disease: associations with COMT and DRD2 polymorphisms. Scandinavian Journal of Psychology. 55: 278-86. PMID 24749760 DOI: 10.1111/sjop.12113  0.315
2013 Santiago JA, Scherzer CR, Potashkin JA, Hyman BT, Ivinson AJ, Trisini-Lipsanopoulos A, Dhima K, Bayer S, Lockhart KC, Yi T, Liao Z, Hoesing AN, Duong K, Roderick S, Sudarsky LR, et al. Specific splice variants are associated with Parkinson's disease Movement Disorders. 28: 1724-1727. PMID 24108702 DOI: 10.1002/mds.25635  0.367
2013 Thomas B, Matson S, Chopra V, Sun L, Sharma S, Hersch S, Rosas HD, Scherzer C, Ferrante R, Matson W. A novel method for detecting 7-methyl guanine reveals aberrant methylation levels in Huntington disease. Analytical Biochemistry. 436: 112-20. PMID 23416183 DOI: 10.1016/J.Ab.2013.01.035  0.302
2011 Ding H, Sarokhan AK, Roderick SS, Bakshi R, Maher NE, Ashourian P, Kan CG, Chang S, Santarlasci A, Swords KE, Ravina BM, Hayes MT, Sohur US, Wills AM, Flaherty AW, ... ... Scherzer CR, et al. Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study. Movement Disorders : Official Journal of the Movement Disorder Society. 26: 2283-6. PMID 21953863 DOI: 10.1002/Mds.23934  0.387
2010 Zheng B, Liao Z, Locascio JJ, Lesniak KA, Roderick SS, Watt ML, Eklund AC, Zhang-James Y, Kim PD, Hauser MA, Grünblatt E, Moran LB, Mandel SA, Riederer P, Miller RM, ... ... Scherzer CR, et al. PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease. Science Translational Medicine. 2: 52ra73. PMID 20926834 DOI: 10.1126/Scitranslmed.3001059  0.375
2010 Khurana V, Elson-Schwab I, Fulga TA, Sharp KA, Loewen CA, Mulkearns E, Tyynelä J, Scherzer CR, Feany MB. Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo. Plos Genetics. 6: e1001026. PMID 20664788 DOI: 10.1371/Journal.Pgen.1001026  0.341
2009 Scherzer C. Interview with Clemens Scherzer--searching for biomarkers in Parkinson's disease. Biomarkers in Medicine. 3: 113-4. PMID 20477503 DOI: 10.2217/Bmm.09.10  0.405
2009 Liao Z, Bakshi R, Bresnick E, Schlossmacher M, Zheng B, Scherzer C. P3.042 A GATA-2-switch model of a-synuclein overexpression in sporadic Parkinson's disease Parkinsonism & Related Disorders. 15: S159. DOI: 10.1016/S1353-8020(09)70606-6  0.419
2009 Kay D, Montimurro J, Schlossmacher M, Bresnick E, Stevens C, Zabetian C, Factor S, Higgins D, Scherzer C, Payami H. P3.039 Polymorphisms in the transcription factor gene GATA2 and GATA-2 target region in a-synuclein (SNCA) are associated with Parkinson's disease (PD) Parkinsonism & Related Disorders. 15: S158. DOI: 10.1016/S1353-8020(09)70603-0  0.454
2008 Hennecke G, Scherzer CR. RNA biomarkers of Parkinson's disease: developing tools for novel therapies. Biomarkers in Medicine. 2: 41-53. PMID 20477362 DOI: 10.2217/17520363.2.1.41  0.373
2008 Scherzer CR, Grass JA, Liao Z, Pepivani I, Zheng B, Eklund AC, Ney PA, Ng J, McGoldrick M, Mollenhauer B, Bresnick EH, Schlossmacher MG. GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein. Proceedings of the National Academy of Sciences of the United States of America. 105: 10907-12. PMID 18669654 DOI: 10.1073/Pnas.0802437105  0.331
2007 Scherzer CR, Eklund AC, Morse LJ, Liao Z, Locascio JJ, Fefer D, Schwarzschild MA, Schlossmacher MG, Hauser MA, Vance JM, Sudarsky LR, Standaert DG, Growdon JH, Jensen RV, Gullans SR. Molecular markers of early Parkinson's disease based on gene expression in blood. Proceedings of the National Academy of Sciences of the United States of America. 104: 955-60. PMID 17215369 DOI: 10.1073/Pnas.0610204104  0.577
2005 Hauser MA, Li YJ, Xu H, Noureddine MA, Shao YS, Gullans SR, Scherzer CR, Jensen RV, McLaurin AC, Gibson JR, Scott BL, Jewett RM, Stenger JE, Schmechel DE, Hulette CM, et al. Expression profiling of substantia nigra in Parkinson disease, progressive supranuclear palsy, and frontotemporal dementia with parkinsonism. Archives of Neurology. 62: 917-21. PMID 15956162 DOI: 10.1001/Archneur.62.6.917  0.343
2004 Scherzer CR, Feany MB. Yeast genetics targets lipids in Parkinson's disease. Trends in Genetics : Tig. 20: 273-7. PMID 15219388 DOI: 10.1016/J.Tig.2004.05.005  0.352
2004 Gilbert JR, Xu P, Li Y, Qin X, Schmechel D, Hulette C, McLaurin A, Scherzer C, Gullans SR, Haines JL, Pericak-Vance MA. P4-103 APOE allele specific gene expression in Alzheimer's and control hippocampus Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81661-0  0.308
2003 Li YJ, Oliveira SA, Xu P, Martin ER, Stenger JE, Scherzer CR, Hauser MA, Scott WK, Small GW, Nance MA, Watts RL, Hubble JP, Koller WC, Pahwa R, Stern MB, et al. Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. Human Molecular Genetics. 12: 3259-67. PMID 14570706 DOI: 10.1093/Hmg/Ddg357  0.324
2003 Scherzer CR, Jensen RV, Gullans SR, Feany MB. Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease. Human Molecular Genetics. 12: 2457-66. PMID 12915459 DOI: 10.1093/Hmg/Ddg265  0.307
1998 Counihan TJ, Landwehrmeyer GB, Standaert DG, Kosinski CM, Scherzer CR, Daggett LP, Veliçelebi G, Young AB, Penney JB. Expression of N-methyl-D-aspartate receptor subunit mRNA in the human brain: mesencephalic dopaminergic neurons. The Journal of Comparative Neurology. 390: 91-101. PMID 9456178 DOI: 10.1002/(SICI)1096-9861(19980105)390:1<91::AID-CNE8>3.0.CO;2-L  0.527
1998 Scherzer CR, Landwehrmeyer GB, Kerner JA, Counihan TJ, Kosinski CM, Standaert DG, Daggett LP, Veliçelebi G, Penney JB, Young AB. Expression of N-methyl-D-aspartate receptor subunit mRNAs in the human brain: hippocampus and cortex. The Journal of Comparative Neurology. 390: 75-90. PMID 9456177 DOI: 10.1002/(SICI)1096-9861(19980105)390:1<75::AID-CNE7>3.0.CO;2-N  0.441
1998 Kosinski CM, Standaert DG, Counihan TJ, Scherzer CR, Kerner JA, Daggett LP, Veliçelebi G, Penney JB, Young AB, Landwehrmeyer GB. Expression of N-methyl-D-aspartate receptor subunit mRNAs in the human brain: striatum and globus pallidus. The Journal of Comparative Neurology. 390: 63-74. PMID 9456176 DOI: 10.1002/(SICI)1096-9861(19980105)390:1<63::AID-CNE6>3.0.CO;2-O  0.464
1997 Scherzer CR, Landwehrmeyer GB, Kerner JA, Standaert DG, Hollingsworth ZR, Daggett LP, Veliçelebi G, Penney JB, Young AB. Cellular distribution of NMDA glutamate receptor subunit mRNAs in the human cerebellum. Neurobiology of Disease. 4: 35-46. PMID 9258910 DOI: 10.1006/nbdi.1997.0136  0.437
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