Eileen McGowan - Publications

Affiliations: 
Mayo Clinic Jacksonville, Jacksonville, FL, United States 

50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2011 Morgan D, Munireddy S, Alamed J, DeLeon J, Diamond DM, Bickford P, Hutton M, Lewis J, McGowan E, Gordon MN. Apparent behavioral benefits of tau overexpression in P301L tau transgenic mice Advances in Alzheimer's Disease. 1: 129-138. DOI: 10.3233/978-1-60750-733-8-129  0.84
2010 Xu YF, Gendron TF, Zhang YJ, Lin WL, D'Alton S, Sheng H, Casey MC, Tong J, Knight J, Yu X, Rademakers R, Boylan K, Hutton M, McGowan E, Dickson DW, et al. Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 10851-9. PMID 20702714 DOI: 10.1523/JNEUROSCI.1630-10.2010  0.84
2010 Ahmed Z, Sheng H, Xu YF, Lin WL, Innes AE, Gass J, Yu X, Wuertzer CA, Hou H, Chiba S, Yamanouchi K, Leissring M, Petrucelli L, Nishihara M, Hutton ML, ... McGowan E, et al. Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging. The American Journal of Pathology. 177: 311-24. PMID 20522652 DOI: 10.2353/ajpath.2010.090915  0.84
2010 Salek RM, Xia J, Innes A, Sweatman BC, Adalbert R, Randle S, McGowan E, Emson PC, Griffin JL. A metabolomic study of the CRND8 transgenic mouse model of Alzheimer's disease. Neurochemistry International. 56: 937-47. PMID 20398713 DOI: 10.1016/j.neuint.2010.04.001  0.84
2010 Ahmed Z, Sheng H, Xu YF, Lin WL, Innes AE, Gass J, Yu X, Wuertzer CA, Hou H, Chiba S, Yamanouchi K, Leissring M, Petrucelli L, Nishihara M, Hutton ML, ... McGowan E, et al. Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging (American Journal of Pathology (2010), 177, (311-324)) American Journal of Pathology. 177: 2146. DOI: 10.2353/ajpath.2010.100772  0.84
2009 Adams SJ, Crook RJ, Deture M, Randle SJ, Innes AE, Yu XZ, Lin WL, Dugger BN, McBride M, Hutton M, Dickson DW, McGowan E. Overexpression of wild-type murine tau results in progressive tauopathy and neurodegeneration. The American Journal of Pathology. 175: 1598-609. PMID 19717642 DOI: 10.2353/ajpath.2009.090462  0.84
2009 Pereson S, Wils H, Kleinberger G, McGowan E, Vandewoestyne M, Van Broeck B, Joris G, Cuijt I, Deforce D, Hutton M, Van Broeckhoven C, Kumar-Singh S. Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models. The Journal of Pathology. 219: 173-81. PMID 19557827 DOI: 10.1002/path.2580  0.84
2009 Cook C, Gass J, Dunmore J, Tong J, Taylor J, Eriksen J, McGowan E, Lewis J, Johnston J, Petrucelli L. Aging is not associated with proteasome impairment in UPS reporter mice. Plos One. 4: e5888. PMID 19517018 DOI: 10.1371/journal.pone.0005888  0.84
2008 Morgan D, Munireddy S, Alamed J, DeLeon J, Diamond DM, Bickford P, Hutton M, Lewis J, McGowan E, Gordon MN. Apparent behavioral benefits of tau overexpression in P301L tau transgenic mice. Journal of Alzheimer's Disease : Jad. 15: 605-14. PMID 19096159  0.84
2008 Matsuda S, Giliberto L, Matsuda Y, McGowan EM, D'Adamio L. BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 8668-76. PMID 18753367 DOI: 10.1523/JNEUROSCI.2094-08.2008  0.84
2008 Stokin GB, Almenar-Queralt A, Gunawardena S, Rodrigues EM, Falzone T, Kim J, Lillo C, Mount SL, Roberts EA, McGowan E, Williams DS, Goldstein LS. Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides. Human Molecular Genetics. 17: 3474-86. PMID 18694898 DOI: 10.1093/hmg/ddn240  0.84
2008 Paulson JB, Ramsden M, Forster C, Sherman MA, McGowan E, Ashe KH. Amyloid plaque and neurofibrillary tangle pathology in a regulatable mouse model of Alzheimer's disease. The American Journal of Pathology. 173: 762-72. PMID 18669616 DOI: 10.2353/ajpath.2008.080175  0.84
2007 Ahmed Z, Shaw G, Sharma VP, Yang C, McGowan E, Dickson DW. Actin-binding proteins coronin-1a and IBA-1 are effective microglial markers for immunohistochemistry. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 55: 687-700. PMID 17341475 DOI: 10.1369/jhc.6A7156.2007  0.84
2007 Kim J, Onstead L, Randle S, Price R, Smithson L, Zwizinski C, Dickson DW, Golde T, McGowan E. Abeta40 inhibits amyloid deposition in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 627-33. PMID 17234594 DOI: 10.1523/JNEUROSCI.4849-06.2007  0.84
2006 Levites Y, Smithson LA, Price RW, Dakin RS, Yuan B, Sierks MR, Kim J, McGowan E, Reed DK, Rosenberry TL, Das P, Golde TE. Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 2576-8. PMID 17068112 DOI: 10.1096/fj.06-6463fje  0.84
2006 Baker M, Mackenzie IR, Pickering-Brown SM, Gass J, Rademakers R, Lindholm C, Snowden J, Adamson J, Sadovnick AD, Rollinson S, Cannon A, Dwosh E, Neary D, Melquist S, Richardson A, ... ... McGowan E, et al. Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature. 442: 916-9. PMID 16862116 DOI: 10.1038/nature05016  0.84
2006 Le Corre S, Klafki HW, Plesnila N, Hübinger G, Obermeier A, Sahagún H, Monse B, Seneci P, Lewis J, Eriksen J, Zehr C, Yue M, McGowan E, Dickson DW, Hutton M, et al. An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 103: 9673-8. PMID 16769887 DOI: 10.1073/pnas.0602913103  0.84
2006 Pickford F, Coomaraswamy J, Jucker M, McGowan E. Modeling familial British dementia in transgenic mice. Brain Pathology (Zurich, Switzerland). 16: 80-5. PMID 16612985  0.84
2006 McGowan E, Eriksen J, Hutton M. A decade of modeling Alzheimer's disease in transgenic mice. Trends in Genetics : Tig. 22: 281-9. PMID 16567017 DOI: 10.1016/j.tig.2006.03.007  0.84
2006 Levites Y, Das P, Price RW, Rochette MJ, Kostura LA, McGowan EM, Murphy MP, Golde TE. Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model. The Journal of Clinical Investigation. 116: 193-201. PMID 16341263 DOI: 10.1172/JCI25410  0.84
2005 Ramsden M, Kotilinek L, Forster C, Paulson J, McGowan E, SantaCruz K, Guimaraes A, Yue M, Lewis J, Carlson G, Hutton M, Ashe KH. Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L). The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10637-47. PMID 16291936 DOI: 10.1523/JNEUROSCI.3279-05.2005  0.84
2005 Kumar-Singh S, Pirici D, McGowan E, Serneels S, Ceuterick C, Hardy J, Duff K, Dickson D, Van Broeckhoven C. Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls. The American Journal of Pathology. 167: 527-43. PMID 16049337 DOI: 10.1016/S0002-9440(10)62995-1  0.84
2005 McGowan E, Pickford F, Kim J, Onstead L, Eriksen J, Yu C, Skipper L, Murphy MP, Beard J, Das P, Jansen K, Delucia M, Lin WL, Dolios G, Wang R, et al. Abeta42 is essential for parenchymal and vascular amyloid deposition in mice. Neuron. 47: 191-9. PMID 16039562 DOI: 10.1016/j.neuron.2005.06.030  0.84
2005 Santacruz K, Lewis J, Spires T, Paulson J, Kotilinek L, Ingelsson M, Guimaraes A, DeTure M, Ramsden M, McGowan E, Forster C, Yue M, Orne J, Janus C, Mariash A, et al. Tau suppression in a neurodegenerative mouse model improves memory function. Science (New York, N.Y.). 309: 476-81. PMID 16020737 DOI: 10.1126/science.1113694  1
2005 Matsuda S, Giliberto L, Matsuda Y, Davies P, McGowan E, Pickford F, Ghiso J, Frangione B, D'Adamio L. The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production. The Journal of Biological Chemistry. 280: 28912-6. PMID 15983050 DOI: 10.1074/jbc.C500217200  0.84
2004 Hutton M, McGowan E. Clearing tau pathology with Abeta immunotherapy--reversible and irreversible stages revealed. Neuron. 43: 293-4. PMID 15294135 DOI: 10.1016/j.neuron.2004.07.023  1
2004 Sahara N, Vega IE, Ishizawa T, Lewis J, McGowan E, Hutton M, Dickson D, Yen SH. Phosphorylated p38MAPK specific antibodies cross-react with sarkosyl-insoluble hyperphosphorylated tau proteins. Journal of Neurochemistry. 90: 829-38. PMID 15287888 DOI: 10.1111/j.1471-4159.2004.02558.x  0.84
2004 Arendash GW, Lewis J, Leighty RE, McGowan E, Cracchiolo JR, Hutton M, Garcia MF. Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain. Brain Research. 1012: 29-41. PMID 15158158 DOI: 10.1016/j.brainres.2004.02.081  0.84
2004 Garcia MF, Gordon MN, Hutton M, Lewis J, McGowan E, Dickey CA, Morgan D, Arendash GW. The retinal degeneration (rd) gene seriously impairs spatial cognitive performance in normal and Alzheimer's transgenic mice. Neuroreport. 15: 73-7. PMID 15106834 DOI: 10.1097/00001756-200401190-00015  0.84
2004 Zehr C, Lewis J, McGowan E, Crook J, Lin WL, Godwin K, Knight J, Dickson DW, Hutton M. Apoptosis in oligodendrocytes is associated with axonal degeneration in P301L tau mice. Neurobiology of Disease. 15: 553-62. PMID 15056463 DOI: 10.1016/j.nbd.2003.12.011  0.84
2004 Petrucelli L, Dickson D, Kehoe K, Taylor J, Snyder H, Grover A, De Lucia M, McGowan E, Lewis J, Prihar G, Kim J, Dillmann WH, Browne SE, Hall A, Voellmy R, et al. CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. Human Molecular Genetics. 13: 703-14. PMID 14962978 DOI: 10.1093/hmg/ddh083  0.84
2003 Ishizawa T, Sahara N, Ishiguro K, Kersh J, McGowan E, Lewis J, Hutton M, Dickson DW, Yen SH. Co-localization of glycogen synthase kinase-3 with neurofibrillary tangles and granulovacuolar degeneration in transgenic mice. The American Journal of Pathology. 163: 1057-67. PMID 12937146 DOI: 10.1016/S0002-9440(10)63465-7  0.84
2003 Pickford F, Onstead L, Camacho-Prihar C, Hardy J, McGowan E. Expression of mBRI2 in mice. Neuroscience Letters. 338: 95-8. PMID 12566161 DOI: 10.1016/S0304-3940(02)01356-3  0.84
2002 Sahara N, Lewis J, DeTure M, McGowan E, Dickson DW, Hutton M, Yen SH. Assembly of tau in transgenic animals expressing P301L tau: alteration of phosphorylation and solubility. Journal of Neurochemistry. 83: 1498-508. PMID 12472903 DOI: 10.1046/j.1471-4159.2002.01241.x  0.84
2002 Augood SJ, McGowan EM, Finsen BR, Heppelmann B, Emson PC. Non-radioactive in situ hybridization using alkaline phosphatase-labelled oligonucleotides. International Review of Neurobiology. 47: 173-201. PMID 12198799  0.84
2002 O'Farrell C, Pickford F, Vink L, McGowan E, Cookson MR. Sequence conservation between mouse and human synphilin-1. Neuroscience Letters. 322: 9-12. PMID 11958831 DOI: 10.1016/S0304-3940(02)00068-X  0.84
2001 Hutton M, Lewis J, Dickson D, Yen SH, McGowan E. Analysis of tauopathies with transgenic mice. Trends in Molecular Medicine. 7: 467-70. PMID 11597522 DOI: 10.1016/S1471-4914(01)02123-2  0.84
2001 Lewis J, Dickson DW, Lin WL, Chisholm L, Corral A, Jones G, Yen SH, Sahara N, Skipper L, Yager D, Eckman C, Hardy J, Hutton M, McGowan E. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science (New York, N.Y.). 293: 1487-91. PMID 11520987 DOI: 10.1126/science.1058189  0.84
2001 Lewis PA, Piper S, Baker M, Onstead L, Murphy MP, Hardy J, Wang R, McGowan E, Golde TE. Expression of BRI-amyloid beta peptide fusion proteins: a novel method for specific high-level expression of amyloid beta peptides. Biochimica Et Biophysica Acta. 1537: 58-62. PMID 11476963 DOI: 10.1016/S0925-4439(01)00054-0  0.84
2001 Matsuoka Y, Vila M, Lincoln S, McCormack A, Picciano M, LaFrancois J, Yu X, Dickson D, Langston WJ, McGowan E, Farrer M, Hardy J, Duff K, Przedborski S, Di Monte DA. Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter. Neurobiology of Disease. 8: 535-9. PMID 11442360 DOI: 10.1006/nbdi.2001.0392  0.84
2001 Hernandez D, Sugaya K, Qu T, McGowan E, Duff K, McKinney M. Survival and plasticity of basal forebrain cholinergic systems in mice transgenic for presenilin-1 and amyloid precursor protein mutant genes. Neuroreport. 12: 1377-84. PMID 11388415  0.84
2000 Houlden H, Baker M, McGowan E, Lewis P, Hutton M, Crook R, Wood NW, Kumar-Singh S, Geddes J, Swash M, Scaravilli F, Holton JL, Lashley T, Tomita T, Hashimoto T, et al. Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS-1 mutations that lead to exceptionally high amyloid-beta concentrations. Annals of Neurology. 48: 806-8. PMID 11079548 DOI: 10.1002/1531-8249(200011)48:5<806::AID-ANA18>3.0.CO;2-F  0.84
2000 Lewis J, McGowan E, Rockwood J, Melrose H, Nacharaju P, Van Slegtenhorst M, Gwinn-Hardy K, Paul Murphy M, Baker M, Yu X, Duff K, Hardy J, Corral A, Lin WL, Yen SH, et al. Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nature Genetics. 25: 402-5. PMID 10932182 DOI: 10.1038/78078  0.84
1999 McGowan E, Sanders S, Iwatsubo T, Takeuchi A, Saido T, Zehr C, Yu X, Uljon S, Wang R, Mann D, Dickson D, Duff K. Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes. Neurobiology of Disease. 6: 231-44. PMID 10448051 DOI: 10.1006/nbdi.1999.0243  0.84
1999 Prihar G, Gonzalez de Chavez F, Baker M, Crook R, McGowan E, Grover A, Hardy J, Hutton M. A novel candidate presenilin-1 interacting protein containing tetratricopeptide repeats. Neuroreport. 10: 1409-15. PMID 10380955  1
1998 Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P, Wright K, Saad I, Mueller R, Morgan D, Sanders S, Zehr C, O'Campo K, Hardy J, Prada CM, et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nature Medicine. 4: 97-100. PMID 9427614 DOI: 10.1038/nm0198-097  0.84
1997 Benkovic SA, McGowan EM, Rothwell NJ, Hutton M, Morgan DG, Gordon MN. Regional and cellular localization of presenilin-2 RNA in rat and human brain. Experimental Neurology. 145: 555-64. PMID 9217091 DOI: 10.1006/exnr.1997.6487  1
1994 Augood SJ, McGowan EM, Emson PC. Expression of N-methyl-D-aspartate receptor subunit NR1 messenger RNA by identified striatal somatostatin cells. Neuroscience. 59: 7-12. PMID 7910673 DOI: 10.1016/0306-4522(94)90093-0  0.84
1993 Kadowaki K, McGowan E, Mock G, Chandler S, Emson PC. Distribution of calcium binding protein mRNAs in rat cerebellar cortex. Neuroscience Letters. 153: 80-4. PMID 8510828 DOI: 10.1016/0304-3940(93)90082-V  0.84
1992 Herbison AE, Augood SJ, McGowan EM. Expression of glutamic acid decarboxylase messenger RNA in rat medial preoptic area neurones during the oestrous cycle and after ovariectomy. Brain Research. Molecular Brain Research. 14: 310-6. PMID 1326694 DOI: 10.1016/0169-328X(92)90098-V  0.84
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