Serge Przedborski, Md - Publications

Affiliations: 
Columbia University, New York, NY 
Area:
Neurodegeneration, Neurobiology of Disease, Molecular and Cellular Biology of Neurodegeneration, Parkinson's Disease, Motor Neuron Biology and Diseases, Amyotrophic Lateral Sclerosis, Mitochondria Biology and Disease, Mitophagy, Neuroinflammation, Microgl

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Year Citation  Score
2021 Riboldi GM, Faravelli I, Kuwajima T, Delestrée N, Dermentzaki G, De Planell-Saguer M, Rinchetti P, Hao LT, Beattie CC, Corti S, Przedborski S, Mentis GZ, Lotti F. Sumoylation regulates the assembly and activity of the SMN complex. Nature Communications. 12: 5040. PMID 34413305 DOI: 10.1038/s41467-021-25272-5  0.749
2021 Van Harten ACM, Phatnani H, Przedborski S. Non-cell-autonomous pathogenic mechanisms in amyotrophic lateral sclerosis. Trends in Neurosciences. PMID 34006386 DOI: 10.1016/j.tins.2021.04.008  0.327
2020 Mishra V, Re DB, Le Verche V, Alvarez MJ, Vasciaveo A, Jacquier A, Doulias PT, Greco TM, Nizzardo M, Papadimitriou D, Nagata T, Rinchetti P, Perez-Torres EJ, Politi KA, Ikiz B, ... ... Przedborski S, et al. Systematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow. Nature Communications. 11: 5579. PMID 33149111 DOI: 10.1038/s41467-020-19177-y  0.783
2019 Ji R, Smith M, Niimi Y, Karakatsani ME, Murillo MF, Jackson-Lewis V, Przedborski S, Konofagou EE. Focused ultrasound enhanced intranasal delivery of brain derived neurotrophic factor produces neurorestorative effects in a Parkinson's disease mouse model. Scientific Reports. 9: 19402. PMID 31852909 DOI: 10.1038/S41598-019-55294-5  0.385
2019 Karakatsani ME, Wang S, Samiotaki G, Kugelman T, Olumolade OO, Acosta C, Sun T, Han Y, Kamimura HAS, Jackson-Lewis V, Przedborski S, Konofagou E. Amelioration of the nigrostriatal pathway facilitated by ultrasound-mediated neurotrophic delivery in early Parkinson's disease. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 30953664 DOI: 10.1016/J.Jconrel.2019.03.030  0.401
2019 Dermentzaki G, Politi KA, Lu L, Mishra V, Pérez-Torres EJ, Sosunov AA, McKhann GM, Lotti F, Shneider NA, Przedborski S. Deletion of Prevents Motor Neuron Death but not . Eneuro. 6. PMID 30815534 DOI: 10.1523/ENEURO.0308-18.2018  0.303
2019 Area-Gomez E, Guardia-Laguarta C, Schon EA, Przedborski S. Mitochondria, OxPhos, and neurodegeneration: cells are not just running out of gas. The Journal of Clinical Investigation. 129: 34-45. PMID 30601141 DOI: 10.1172/Jci120848  0.358
2018 Antoniou N, Vlachakis D, Memou A, Leandrou E, Valkimadi PE, Melachroinou K, Re DB, Przedborski S, Dauer WT, Stefanis L, Rideout HJ. A motif within the armadillo repeat of Parkinson's-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway. Scientific Reports. 8: 3455. PMID 29472595 DOI: 10.1038/S41598-018-21931-8  0.395
2018 Steinkellner T, Zell V, Farino ZJ, Sonders MS, Villeneuve M, Freyberg RJ, Przedborski S, Lu W, Freyberg Z, Hnasko TS. Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons. The Journal of Clinical Investigation. PMID 29337309 DOI: 10.1172/Jci95795  0.366
2017 Obeso JA, Stamelou M, Goetz CG, Poewe W, Lang AE, Weintraub D, Burn D, Halliday GM, Bezard E, Przedborski S, Lehericy S, Brooks DJ, Rothwell JC, Hallett M, DeLong MR, et al. Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy. Movement Disorders : Official Journal of the Movement Disorder Society. 32: 1264-1310. PMID 28887905 DOI: 10.1002/Mds.27115  0.556
2017 Przedborski S. The two-century journey of Parkinson disease research. Nature Reviews. Neuroscience. 18: 251-259. PMID 28303016 DOI: 10.1038/Nrn.2017.25  0.376
2017 Zhang H, Sanchez CS, Kwon N, Jackson-Lewis VR, Przedborski S, Konofagou E. Focused-ultrasound mediated anti-alpha-synuclein antibody delivery for the treatment of Parkinson’s disease The Journal of the Acoustical Society of America. 142: 2721-2721. DOI: 10.1121/1.5014928  0.378
2016 Hasegawa K, Yasuda T, Shiraishi C, Fujiwara K, Przedborski S, Mochizuki H, Yoshikawa K. Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults. Nature Communications. 7: 10943. PMID 26971449 DOI: 10.1038/Ncomms10943  0.363
2015 Brichta L, Shin W, Jackson-Lewis V, Blesa J, Yap EL, Walker Z, Zhang J, Roussarie JP, Alvarez MJ, Califano A, Przedborski S, Greengard P. Identification of neurodegenerative factors using translatome-regulatory network analysis. Nature Neuroscience. PMID 26214373 DOI: 10.1038/Nn.4070  0.378
2015 Ikiz B, Alvarez MJ, Ré DB, Le Verche V, Politi K, Lotti F, Phani S, Pradhan R, Yu C, Croft GF, Jacquier A, Henderson CE, Califano A, Przedborski S. The Regulatory Machinery of Neurodegeneration in In Vitro Models of Amyotrophic Lateral Sclerosis. Cell Reports. 12: 335-45. PMID 26146077 DOI: 10.1016/J.Celrep.2015.06.019  0.785
2015 Dehay B, Bourdenx M, Gorry P, Przedborski S, Vila M, Hunot S, Singleton A, Olanow CW, Merchant KM, Bezard E, Petsko GA, Meissner WG. Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations. The Lancet. Neurology. PMID 26050140 DOI: 10.1016/S1474-4422(15)00006-X  0.779
2015 Kett LR, Stiller B, Bernath MM, Tasset I, Blesa J, Jackson-Lewis V, Chan RB, Zhou B, Di Paolo G, Przedborski S, Cuervo AM, Dauer WT. α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 5724-42. PMID 25855184 DOI: 10.1523/Jneurosci.0632-14.2015  0.591
2015 Konofagou E, Samiotaki G, Wang S, Jackson-Lewis V, Przedborski S. Neuroprotection and neuroregeneration triggered through the FUS-induced opening of the blood-brain barrier in a Parkinson’s mouse model Journal of Therapeutic Ultrasound. 3. DOI: 10.1186/2050-5736-3-S1-O19  0.351
2014 Blesa J, Przedborski S. Parkinson's disease: animal models and dopaminergic cell vulnerability. Frontiers in Neuroanatomy. 8: 155. PMID 25565980 DOI: 10.3389/Fnana.2014.00155  0.417
2014 Le Masson G, Przedborski S, Abbott LF. A computational model of motor neuron degeneration. Neuron. 83: 975-88. PMID 25088365 DOI: 10.1016/J.Neuron.2014.07.001  0.361
2014 Re DB, Le Verche V, Yu C, Amoroso MW, Politi KA, Phani S, Ikiz B, Hoffmann L, Koolen M, Nagata T, Papadimitriou D, Nagy P, Mitsumoto H, Kariya S, Wichterle H, ... ... Przedborski S, et al. Necroptosis drives motor neuron death in models of both sporadic and familial ALS. Neuron. 81: 1001-8. PMID 24508385 DOI: 10.1016/J.Neuron.2014.01.011  0.788
2014 Ikiz B, Alvarez MJ, Ré DB, LeVerche V, Politi K, Lotti F, Phani S, Pradhan R, Yu C, Croft GF, Jacquier A, Henderson CE, Califano A, Przedborski S. The Regulatory Machinery of Neurodegeneration in InVitro Models of Amyotrophic Lateral Sclerosis Cell Reports. DOI: 10.1016/j.celrep.2015.06.019  0.757
2013 Roybon L, Lamas NJ, Garcia-Diaz A, Yang EJ, Sattler R, Jackson-Lewis V, Kim YA, Kachel CA, Rothstein JD, Przedborski S, Wichterle H, Henderson CE. Human stem cell-derived spinal cord astrocytes with defined mature or reactive phenotypes. Cell Reports. 4: 1035-48. PMID 23994478 DOI: 10.1016/J.Celrep.2013.06.021  0.453
2013 Ravits J, Appel S, Baloh RH, Barohn R, Brooks BR, Elman L, Floeter MK, Henderson C, Lomen-Hoerth C, Macklis JD, McCluskey L, Mitsumoto H, Przedborski S, Rothstein J, Trojanowski JQ, et al. Deciphering amyotrophic lateral sclerosis: what phenotype, neuropathology and genetics are telling us about pathogenesis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 14: 5-18. PMID 23678876 DOI: 10.3109/21678421.2013.778548  0.601
2013 Hirsch EC, Jenner P, Przedborski S. Pathogenesis of Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 28: 24-30. PMID 22927094 DOI: 10.1002/Mds.25032  0.4
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Przedborski S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496  0.666
2012 Phani S, Re DB, Przedborski S. The Role of the Innate Immune System in ALS. Frontiers in Pharmacology. 3: 150. PMID 22912616 DOI: 10.3389/Fphar.2012.00150  0.447
2012 Gonzalez-Reyes LE, Verbitsky M, Blesa J, Jackson-Lewis V, Paredes D, Tillack K, Phani S, Kramer ER, Przedborski S, Kottmann AH. Sonic hedgehog maintains cellular and neurochemical homeostasis in the adult nigrostriatal circuit. Neuron. 75: 306-19. PMID 22841315 DOI: 10.1016/J.Neuron.2012.05.018  0.306
2012 Kariya S, Re DB, Jacquier A, Nelson K, Przedborski S, Monani UR. Mutant superoxide dismutase 1 (SOD1), a cause of amyotrophic lateral sclerosis, disrupts the recruitment of SMN, the spinal muscular atrophy protein to nuclear cajal bodies Human Molecular Genetics. 21: 3421-3434. PMID 22581780 DOI: 10.1093/hmg/dds174  0.32
2012 Blesa J, Phani S, Jackson-Lewis V, Przedborski S. Classic and new animal models of Parkinson's disease. Journal of Biomedicine & Biotechnology. 2012: 845618. PMID 22536024 DOI: 10.1155/2012/845618  0.393
2012 Phani S, Loike JD, Przedborski S. Neurodegeneration and inflammation in Parkinson's disease. Parkinsonism & Related Disorders. 18: S207-9. PMID 22166436 DOI: 10.1016/S1353-8020(11)70064-5  0.423
2012 Jackson-Lewis V, Blesa J, Przedborski S. Animal models of Parkinson's disease. Parkinsonism & Related Disorders. 18: S183-5. PMID 22166429 DOI: 10.1016/S1353-8020(11)70057-8  0.355
2012 Lim L, Jackson-Lewis V, Wong LC, Shui GH, Goh AX, Kesavapany S, Jenner AM, Fivaz M, Przedborski S, Wenk MR. Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease. Cell Death and Differentiation. 19: 416-27. PMID 21818119 DOI: 10.1038/cdd.2011.105  0.335
2012 Lim S, Chesser A, Grima J, Rappold P, Blum D, Przedborski S, Tieu K. 3.260 D-β-HYDROXYBUTYRATE IS NEUROPROTECTIVE IN MOUSE MODELS OF HUNTINGTON'S DISEASE Parkinsonism & Related Disorders. 18: S218. DOI: 10.1016/S1353-8020(11)70931-2  0.303
2012 Yasuda T, Yoshikawa K, Przedborski S, Mizuno Y, Mochizuki H. 3.205 Necdin Prevents Loss Of Dopaminergic Neurons In Animal Models Of Parkinson'S Disease Parkinsonism & Related Disorders. 18. DOI: 10.1016/S1353-8020(11)70878-1  0.428
2011 Lim S, Chesser AS, Grima JC, Rappold PM, Blum D, Przedborski S, Tieu K. D-β-hydroxybutyrate is protective in mouse models of Huntington's disease. Plos One. 6: e24620. PMID 21931779 DOI: 10.1371/Journal.Pone.0024620  0.374
2011 Bezard E, Przedborski S. A tale on animal models of Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 26: 993-1002. PMID 21626544 DOI: 10.1002/Mds.23696  0.585
2011 Vives-Bauza C, Przedborski S. Mitophagy: the latest problem for Parkinson's disease. Trends in Molecular Medicine. 17: 158-65. PMID 21146459 DOI: 10.1016/J.Molmed.2010.11.002  0.382
2011 Zhang W, Phillips K, Wielgus AR, Liu J, Albertini A, Zucca FA, Faust R, Qian SY, Miller DS, Chignell CF, Wilson B, Jackson-Lewis V, Przedborski S, Joset D, Loike J, et al. Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease. Neurotoxicity Research. 19: 63-72. PMID 19957214 DOI: 10.1007/S12640-009-9140-Z  0.41
2011 le Verche V, Ikiz B, Jacquier A, Przedborski S, Re DB. Glutamate pathway implication in amyotrophic lateral sclerosis: What is the signal in the noise? Journal of Receptor, Ligand and Channel Research. 4: 1-22. DOI: 10.2147/JRLCR.S6504  0.738
2011 Przedborski S. Can a defect in bioenergetics be involved in the pathogenesis of Parkinson's disease after all?† Movement Disorders. 26: 1408-1408. DOI: 10.1002/Mds.23857  0.355
2010 Le Verche V, Przedborski S. Is amyotrophic lateral sclerosis a mitochondrial channelopathy? Neuron. 67: 523-4. PMID 20797528 DOI: 10.1016/J.Neuron.2010.08.010  0.399
2010 Vives-Bauza C, Tocilescu M, Devries RL, Alessi DM, Jackson-Lewis V, Przedborski S. Control of mitochondrial integrity in Parkinson's disease. Progress in Brain Research. 183: 99-113. PMID 20696317 DOI: 10.1016/S0079-6123(10)83006-7  0.374
2010 Perier C, Bové J, Dehay B, Jackson-Lewis V, Rabinovitch PS, Przedborski S, Vila M. Apoptosis-inducing factor deficiency sensitizes dopaminergic neurons to parkinsonian neurotoxins. Annals of Neurology. 68: 184-92. PMID 20695011 DOI: 10.1002/Ana.22034  0.646
2010 Vives-Bauza C, Przedborski S. PINK1 points Parkin to mitochondria. Autophagy. 6: 674-5. PMID 20484984 DOI: 10.4161/Auto.6.5.12068  0.357
2010 Przedborski S. Inflammation and Parkinson's disease pathogenesis. Movement Disorders : Official Journal of the Movement Disorder Society. 25: S55-7. PMID 20187228 DOI: 10.1002/Mds.22638  0.372
2010 Malagelada C, Jin ZH, Jackson-Lewis V, Przedborski S, Greene LA. Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 1166-75. PMID 20089925 DOI: 10.1523/JNEUROSCI.3944-09.2010  0.315
2010 Vives-Bauza C, Zhou C, Huang Y, Cui M, de Vries RL, Kim J, May J, Tocilescu MA, Liu W, Ko HS, Magrané J, Moore DJ, Dawson VL, Grailhe R, Dawson TM, ... ... Przedborski S, et al. PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proceedings of the National Academy of Sciences of the United States of America. 107: 378-83. PMID 19966284 DOI: 10.1073/Pnas.0911187107  0.315
2010 Papadimitriou D, Le Verche V, Jacquier A, Ikiz B, Przedborski S, Re DB. Inflammation in ALS and SMA: Sorting out the good from the evil Neurobiology of Disease. 37: 493-502. PMID 19833209 DOI: 10.1016/J.Nbd.2009.10.005  0.775
2009 Vives-Bauza C, de Vries RL, Tocilescu MA, Przedborski S. Is there a pathogenic role for mitochondria in Parkinson's disease? Parkinsonism & Related Disorders. 15: S241-4. PMID 20083000 DOI: 10.1016/S1353-8020(09)70823-5  0.362
2009 Hoang T, Choi DK, Nagai M, Wu DC, Nagata T, Prou D, Wilson GL, Vila M, Jackson-Lewis V, Dawson VL, Dawson TM, Chesselet MF, Przedborski S. Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson disease. Free Radical Biology & Medicine. 47: 1049-56. PMID 19616617 DOI: 10.1016/J.Freeradbiomed.2009.07.013  0.389
2009 Li Y, Liu W, Oo TF, Wang L, Tang Y, Jackson-Lewis V, Zhou C, Geghman K, Bogdanov M, Przedborski S, Beal MF, Burke RE, Li C. Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nature Neuroscience. 12: 826-8. PMID 19503083 DOI: 10.1038/Nn.2349  0.395
2009 Cui M, Aras R, Christian WV, Rappold PM, Hatwar M, Panza J, Jackson-Lewis V, Javitch JA, Ballatori N, Przedborski S, Tieu K. The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway. Proceedings of the National Academy of Sciences of the United States of America. 106: 8043-8. PMID 19416912 DOI: 10.1073/Pnas.0900358106  0.374
2009 Zhou C, Przedborski S. Intrabody and Parkinson's disease. Biochimica Et Biophysica Acta. 1792: 634-42. PMID 18834937 DOI: 10.1016/J.Bbadis.2008.09.001  0.364
2008 Ikiz B, Przedborski S. A sequel to the tale of p25/Cdk5 in neurodegeneration. Neuron. 60: 731-2. PMID 19081365 DOI: 10.1016/J.Neuron.2008.11.020  0.766
2008 Zhou C, Huang Y, Przedborski S. Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance. Annals of the New York Academy of Sciences. 1147: 93-104. PMID 19076434 DOI: 10.1196/Annals.1427.023  0.43
2008 Zhou C, Huang Y, Shao Y, May J, Prou D, Perier C, Dauer W, Schon EA, Przedborski S. The kinase domain of mitochondrial PINK1 faces the cytoplasm. Proceedings of the National Academy of Sciences of the United States of America. 105: 12022-7. PMID 18687899 DOI: 10.1073/Pnas.0802814105  0.343
2008 Banerjee R, Mosley RL, Reynolds AD, Dhar A, Jackson-Lewis V, Gordon PH, Przedborski S, Gendelman HE. Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice. Plos One. 3: e2740. PMID 18648532 DOI: 10.1371/Journal.Pone.0002740  0.316
2008 Martinez-Vicente M, Talloczy Z, Kaushik S, Massey AC, Mazzulli J, Mosharov EV, Hodara R, Fredenburg R, Wu DC, Follenzi A, Dauer W, Przedborski S, Ischiropoulos H, Lansbury PT, Sulzer D, et al. Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. The Journal of Clinical Investigation. 118: 777-88. PMID 18172548 DOI: 10.1172/Jci32806  0.544
2008 Benner EJ, Banerjee R, Reynolds AD, Sherman S, Pisarev VM, Tsiperson V, Nemachek C, Ciborowski P, Przedborski S, Mosley RL, Gendelman HE. Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons. Plos One. 3: e1376. PMID 18167537 DOI: 10.1371/Journal.Pone.0001376  0.356
2007 Przedborski S. Neuroinflammation and Parkinson's disease. Handbook of Clinical Neurology. 83: 535-51. PMID 18808933 DOI: 10.1016/S0072-9752(07)83026-0  0.396
2007 Andres-Mateos E, Perier C, Zhang L, Blanchard-Fillion B, Greco TM, Thomas B, Ko HS, Sasaki M, Ischiropoulos H, Przedborski S, Dawson TM, Dawson VL. DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proceedings of the National Academy of Sciences of the United States of America. 104: 14807-12. PMID 17766438 DOI: 10.1073/Pnas.0703219104  0.344
2007 Perier C, Bové J, Wu DC, Dehay B, Choi DK, Jackson-Lewis V, Rathke-Hartlieb S, Bouillet P, Strasser A, Schulz JB, Przedborski S, Vila M. Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 104: 8161-6. PMID 17483459 DOI: 10.1073/Pnas.0609874104  0.672
2007 Nagai M, Re DB, Nagata T, Chalazonitis A, Jessell TM, Wichterle H, Przedborski S. Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons. Nature Neuroscience. 10: 615-22. PMID 17435755 DOI: 10.1038/Nn1876  0.41
2007 Jackson-Lewis V, Przedborski S. Protocol for the MPTP mouse model of Parkinson's disease. Nature Protocols. 2: 141-51. PMID 17401348 DOI: 10.1038/Nprot.2006.342  0.372
2007 Whittle AJ, Ross OA, Naini A, Gordon P, Mistumoto H, Dächsel JC, Stone JT, Wszolek ZK, Farrer MJ, Przedborski S. Pathogenic Lrrk2 substitutions and Amyotrophic lateral sclerosis. Journal of Neural Transmission (Vienna, Austria : 1996). 114: 327-9. PMID 16865326 DOI: 10.1007/S00702-006-0525-3  0.354
2006 Dhib-Jalbut S, Arnold DL, Cleveland DW, Fisher M, Friedlander RM, Mouradian MM, Przedborski S, Trapp BD, Wyss-Coray T, Yong VW. Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases. Journal of Neuroimmunology. 176: 198-215. PMID 16983747 DOI: 10.1016/J.Jneuroim.2006.03.027  0.472
2006 Mosharov EV, Staal RG, Bové J, Prou D, Hananiya A, Markov D, Poulsen N, Larsen KE, Moore CM, Troyer MD, Edwards RH, Przedborski S, Sulzer D. Alpha-synuclein overexpression increases cytosolic catecholamine concentration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 9304-11. PMID 16957086 DOI: 10.1523/Jneurosci.0519-06.2006  0.336
2006 Wu DC, Ré DB, Nagai M, Ischiropoulos H, Przedborski S. The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice. Proceedings of the National Academy of Sciences of the United States of America. 103: 12132-7. PMID 16877542 DOI: 10.1073/Pnas.0603670103  0.412
2006 Bové J, Zhou C, Jackson-Lewis V, Taylor J, Chu Y, Rideout HJ, Wu DC, Kordower JH, Petrucelli L, Przedborski S. Proteasome inhibition and Parkinson's disease modeling. Annals of Neurology. 60: 260-4. PMID 16862585 DOI: 10.1002/Ana.20937  0.359
2006 Ré DB, Przedborski S. Fractalkine: moving from chemotaxis to neuroprotection. Nature Neuroscience. 9: 859-61. PMID 16801915 DOI: 10.1038/Nn0706-859  0.363
2006 Kikuchi H, Almer G, Yamashita S, Guégan C, Nagai M, Xu Z, Sosunov AA, McKhann GM, Przedborski S. Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model. Proceedings of the National Academy of Sciences of the United States of America. 103: 6025-30. PMID 16595634 DOI: 10.1073/Pnas.0509227103  0.387
2006 Przedborski S, Vila M. The 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine Mouse Model Annals of the New York Academy of Sciences. 991: 189-198. DOI: 10.1111/J.1749-6632.2003.Tb07476.X  0.413
2005 Bové J, Prou D, Perier C, Przedborski S. Toxin-induced models of Parkinson's disease. Neurorx : the Journal of the American Society For Experimental Neurotherapeutics. 2: 484-94. PMID 16389312 DOI: 10.1602/Neurorx.2.3.484  0.414
2005 Perier C, Tieu K, Guégan C, Caspersen C, Jackson-Lewis V, Carelli V, Martinuzzi A, Hirano M, Przedborski S, Vila M. Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage. Proceedings of the National Academy of Sciences of the United States of America. 102: 19126-31. PMID 16365298 DOI: 10.1073/Pnas.0508215102  0.347
2005 Li X, Rowland LP, Mitsumoto H, Przedborski S, Bird TD, Schellenberg GD, Peskind E, Johnson N, Siddique T, Mesulam MM, Weintraub S, Mastrianni JA. Prion protein codon 129 genotype prevalence is altered in primary progressive aphasia. Annals of Neurology. 58: 858-64. PMID 16315279 DOI: 10.1002/Ana.20646  0.346
2005 Silva RM, Ries V, Oo TF, Yarygina O, Jackson-Lewis V, Ryu EJ, Lu PD, Marciniak SJ, Ron D, Przedborski S, Kholodilov N, Greene LA, Burke RE. CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism. Journal of Neurochemistry. 95: 974-86. PMID 16135078 DOI: 10.1111/J.1471-4159.2005.03428.X  0.442
2005 Choi DK, Pennathur S, Perier C, Tieu K, Teismann P, Wu DC, Jackson-Lewis V, Vila M, Vonsattel JP, Heinecke JW, Przedborski S. Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 6594-600. PMID 16014720 DOI: 10.1523/Jneurosci.0970-05.2005  0.407
2005 Przedborski S, Ischiropoulos H. Reactive oxygen and nitrogen species: weapons of neuronal destruction in models of Parkinson's disease. Antioxidants & Redox Signaling. 7: 685-93. PMID 15890013 DOI: 10.1089/Ars.2005.7.685  0.44
2005 Przedborski S. Pathogenesis of nigral cell death in Parkinson's disease. Parkinsonism & Related Disorders. 11: S3-7. PMID 15885625 DOI: 10.1016/J.Parkreldis.2004.10.012  0.434
2005 Eriksen JL, Przedborski S, Petrucelli L. Gene dosage and pathogenesis of Parkinson's disease. Trends in Molecular Medicine. 11: 91-6. PMID 15760766 DOI: 10.1016/J.Molmed.2005.01.001  0.338
2004 Przedborski S. Molecular targets for neuroprotection. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group On Motor Neuron Diseases. 5: 14-8. PMID 15512862 DOI: 10.1080/1734470410019780  0.387
2004 Przedborski S, Tieu K, Perier C, Vila M. MPTP as a mitochondrial neurotoxic model of Parkinson's disease. Journal of Bioenergetics and Biomembranes. 36: 375-9. PMID 15377875 DOI: 10.1023/B:Jobb.0000041771.66775.D5  0.426
2004 Tieu K, Perier C, Vila M, Caspersen C, Zhang HP, Teismann P, Jackson-Lewis V, Stern DM, Yan SD, Przedborski S. L-3-hydroxyacyl-CoA dehydrogenase II protects in a model of Parkinson's disease. Annals of Neurology. 56: 51-60. PMID 15236401 DOI: 10.1002/Ana.20133  0.379
2004 Benner EJ, Mosley RL, Destache CJ, Lewis TB, Jackson-Lewis V, Gorantla S, Nemachek C, Green SR, Przedborski S, Gendelman HE. Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 101: 9435-40. PMID 15197276 DOI: 10.1073/Pnas.0400569101  0.417
2004 Hayley S, Crocker SJ, Smith PD, Shree T, Jackson-Lewis V, Przedborski S, Mount M, Slack R, Anisman H, Park DS. Regulation of dopaminergic loss by Fas in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2045-53. PMID 14985447 DOI: 10.1523/Jneurosci.4564-03.2004  0.423
2004 Przedborski S. Clarification: Pathogenic role of glial cells in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 19: 118. PMID 14743378 DOI: 10.1002/Mds.10701  0.322
2004 Przedborski S. Programmed cell death in amyotrophic lateral sclerosis: a mechanism of pathogenic and therapeutic importance. The Neurologist. 10: 1-7. PMID 14720310 DOI: 10.1097/01.Nrl.0000106920.84668.37  0.395
2004 Hunot S, Vila M, Teismann P, Davis RJ, Hirsch EC, Przedborski S, Rakic P, Flavell RA. JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 101: 665-70. PMID 14704277 DOI: 10.1073/Pnas.0307453101  0.432
2003 Bezard E, Dovero S, Belin D, Duconger S, Jackson-Lewis V, Przedborski S, Piazza PV, Gross CE, Jaber M. Enriched environment confers resistance to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and cocaine: involvement of dopamine transporter and trophic factors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 10999-1007. PMID 14657156 DOI: 10.1523/Jneurosci.23-35-10999.2003  0.471
2003 Zhang Y, Ona VO, Li M, Drozda M, Dubois-Dauphin M, Przedborski S, Ferrante RJ, Friedlander RM. Sequential activation of individual caspases, and of alterations in Bcl-2 proapoptotic signals in a mouse model of Huntington's disease. Journal of Neurochemistry. 87: 1184-92. PMID 14622098 DOI: 10.1046/J.1471-4159.2003.02105.X  0.344
2003 Smith PD, Crocker SJ, Jackson-Lewis V, Jordan-Sciutto KL, Hayley S, Mount MP, O'Hare MJ, Callaghan S, Slack RS, Przedborski S, Anisman H, Park DS. Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 100: 13650-5. PMID 14595022 DOI: 10.1073/Pnas.2232515100  0.411
2003 Tieu K, Perier C, Caspersen C, Teismann P, Wu DC, Yan SD, Naini A, Vila M, Jackson-Lewis V, Ramasamy R, Przedborski S. D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease. The Journal of Clinical Investigation. 112: 892-901. PMID 12975474 DOI: 10.1172/Jci18797  0.399
2003 Dauer W, Przedborski S. Parkinson's disease: mechanisms and models. Neuron. 39: 889-909. PMID 12971891 DOI: 10.1016/S0896-6273(03)00568-3  0.43
2003 Perier C, Bové J, Vila M, Przedborski S. The rotenone model of Parkinson's disease. Trends in Neurosciences. 26: 345-6. PMID 12850429 DOI: 10.1016/S0166-2236(03)00144-9  0.359
2003 Teismann P, Vila M, Choi DK, Tieu K, Wu DC, Jackson-Lewis V, Przedborski S. COX-2 and neurodegeneration in Parkinson's disease Annals of the New York Academy of Sciences. 991: 272-277. PMID 12846993 DOI: 10.1111/J.1749-6632.2003.Tb07482.X  0.425
2003 Przedborski S, Vila M. The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson's disease. Annals of the New York Academy of Sciences. 991: 189-98. PMID 12846987  0.309
2003 Crocker SJ, Smith PD, Jackson-Lewis V, Lamba WR, Hayley SP, Grimm E, Callaghan SM, Slack RS, Melloni E, Przedborski S, Robertson GS, Anisman H, Merali Z, Park DS. Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4081-91. PMID 12764095 DOI: 10.1523/Jneurosci.23-10-04081.2003  0.431
2003 Vila M, Przedborski S. Targeting programmed cell death in neurodegenerative diseases. Nature Reviews. Neuroscience. 4: 365-75. PMID 12728264 DOI: 10.1038/Nrn1100  0.401
2003 Wu DC, Teismann P, Tieu K, Vila M, Jackson-Lewis V, Ischiropoulos H, Przedborski S. NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 100: 6145-50. PMID 12721370 DOI: 10.1073/Pnas.0937239100  0.41
2003 Teismann P, Tieu K, Choi DK, Wu DC, Naini A, Hunot S, Vila M, Jackson-Lewis V, Przedborski S. Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. 100: 5473-8. PMID 12702778 DOI: 10.1073/Pnas.0837397100  0.419
2003 Teismann P, Tieu K, Cohen O, Choi DK, Wu DC, Marks D, Vila M, Jackson-Lewis V, Przedborski S. Pathogenic role of glial cells in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 18: 121-9. PMID 12539204 DOI: 10.1002/Mds.10332  0.429
2003 Guégan C, Przedborski S. Programmed cell death in amyotrophic lateral sclerosis Journal of Clinical Investigation. 111: 153-161. PMID 12531867 DOI: 10.1172/Jci17610  0.431
2003 Przedborski S, Vila M, Jackson-Lewis V. Neurodegeneration: What is it and where are we? Journal of Clinical Investigation. 111: 3-10. PMID 12511579 DOI: 10.1172/Jci17522  0.442
2003 Przedborski S, Mitsumoto H, Rowland LP. Recent advances in amyotrophic lateral sclerosis research. Current Neurology and Neuroscience Reports. 3: 70-7. PMID 12507415 DOI: 10.1007/S11910-003-0041-X  0.411
2003 Przedborski S, Goldman JE. Pathogenic role of glial cells in Parkinson's disease Advances in Molecular and Cell Biology. 31: 967-982. DOI: 10.1016/S1569-2558(03)31043-4  0.436
2002 Wu DC, Tieu K, Cohen O, Choi DK, Vila M, Jackson-Lewis V, Teismann P, Przedborski S. Glial cell response: A pathogenic factor in Parkinson's disease Journal of Neurovirology. 8: 551-558. PMID 12476349 DOI: 10.1080/13550280290100905  0.424
2002 Drachman DB, Frank K, Dykes-Hoberg M, Teismann P, Almer G, Przedborski S, Rothstein JD. Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS. Annals of Neurology. 52: 771-8. PMID 12447931 DOI: 10.1002/Ana.10374  0.405
2002 Dauer W, Kholodilov N, Vila M, Trillat AC, Goodchild R, Larsen KE, Staal R, Tieu K, Schmitz Y, Yuan CA, Rocha M, Jackson-Lewis V, Hersch S, Sulzer D, Przedborski S, et al. Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP. Proceedings of the National Academy of Sciences of the United States of America. 99: 14524-9. PMID 12376616 DOI: 10.1073/Pnas.172514599  0.38
2002 Guégan C, Vila M, Teismann P, Chen C, Onténiente B, Li M, Friedlander RM, Przedborski S, Teissman P. Instrumental activation of bid by caspase-1 in a transgenic mouse model of ALS. Molecular and Cellular Neurosciences. 20: 553-62. PMID 12213439 DOI: 10.1006/Mcne.2002.1136  0.341
2002 Zhu S, Stavrovskaya IG, Drozda M, Kim BY, Ona V, Li M, Sarang S, Liu AS, Hartley DM, Wu DC, Gullans S, Ferrante RJ, Przedborski S, Kristal BS, Friedlander RM. Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature. 417: 74-8. PMID 11986668 DOI: 10.1038/417074A  0.378
2002 Almer G, Teismann P, Stevic Z, Halaschek-Wiener J, Deecke L, Kostic V, Przedborski S. Increased levels of the pro-inflammatory prostaglandin PGE2 in CSF from ALS patients Neurology. 58: 1277-1279. PMID 11971099 DOI: 10.1212/Wnl.58.8.1277  0.313
2002 Wu DC, Jackson-Lewis V, Vila M, Tieu K, Teismann P, Vadseth C, Choi DK, Ischiropoulos H, Przedborski S. Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 1763-71. PMID 11880505 DOI: 10.1523/Jneurosci.22-05-01763.2002  0.423
2001 Vila M, Wu DC, Przedborski S. Engineered modeling and the secrets of Parkinson's disease Trends in Neurosciences. 24: S49-55. PMID 11881746 DOI: 10.1016/S0166-2236(00)01984-6  0.378
2001 Feigin A, Fukuda M, Dhawan V, Przedborski S, Jackson-Lewis V, Mentis MJ, Moeller JR, Eidelberg D. Metabolic correlates of levodopa response in Parkinson's disease Neurology. 57: 2083-2088. PMID 11739830 DOI: 10.1212/Wnl.57.11.2083  0.326
2001 Petersén A, Hansson O, Puschban Z, Sapp E, Romero N, Castilho RF, Sulzer D, Rice M, DiFiglia M, Przedborski S, Brundin P. Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine. The European Journal of Neuroscience. 14: 1425-35. PMID 11722604 DOI: 10.1046/J.0953-816X.2001.01765.X  0.338
2001 Petersén A A, Larsen KE, Behr GG, Romero N, Przedborski S, Brundin P, Sulzer D. Brain-derived neurotrophic factor inhibits apoptosis and dopamine-induced free radical production in striatal neurons but does not prevent cell death. Brain Research Bulletin. 56: 331-5. PMID 11719268 DOI: 10.1016/S0361-9230(01)00580-9  0.385
2001 Guégan C, Vila M, Rosoklija G, Hays AP, Przedborski S. Recruitment of the mitochondrial-dependent apoptotic pathway in amyotrophic lateral sclerosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 6569-76. PMID 11517246 DOI: 10.1523/Jneurosci.21-17-06569.2001  0.394
2001 Vila M, Jackson-Lewis V, Guégan C, Chu Wu D, Teismann P, Choi DK, Tieu K, Przedborski S. The role of glial cells in Parkinson's disease Current Opinion in Neurology. 14: 483-489. PMID 11470965 DOI: 10.1097/00019052-200108000-00009  0.421
2001 Matsuoka Y, Vila M, Lincoln S, McCormack A, Picciano M, LaFrancois J, Yu X, Dickson D, Langston WJ, McGowan E, Farrer M, Hardy J, Duff K, Przedborski S, Di Monte DA. Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter. Neurobiology of Disease. 8: 535-9. PMID 11442360 DOI: 10.1006/Nbdi.2001.0392  0.361
2001 Petersén A, Larsen KE, Behr GG, Romero N, Przedborski S, Brundin P, Sulzer D. Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration. Human Molecular Genetics. 10: 1243-54. PMID 11406606 DOI: 10.1093/Hmg/10.12.1243  0.412
2001 Vila M, Jackson-Lewis V, Vukosavic S, Djaldetti R, Liberatore G, Offen D, Korsmeyer SJ, Przedborski S. Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease Proceedings of the National Academy of Sciences of the United States of America. 98: 2837-2842. PMID 11226327 DOI: 10.1073/Pnas.051633998  0.449
2001 Almer G, Guégan C, Teismann P, Naini A, Rosoklija G, Hays AP, Chen C, Przedborski S. Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis. Annals of Neurology. 49: 176-85. PMID 11220737 DOI: 10.1002/1531-8249(20010201)49:2<176::Aid-Ana37>3.0.Co;2-X  0.387
2001 Przedborski S, Chen Q, Vila M, Giasson BI, Djaldatti R, Vukosavic S, Souza JM, Jackson-Lewis V, Lee VM, Ischiropoulos H. Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. Journal of Neurochemistry. 76: 637-40. PMID 11208927 DOI: 10.1046/J.1471-4159.2001.00174.X  0.349
2001 Przedborski S, Vila M. MPTP: A review of its mechanisms of neurotoxicity Clinical Neuroscience Research. 1: 407-418. DOI: 10.1016/S1566-2772(01)00019-6  0.409
2000 Vukosavic S, Stefanis L, Jackson-Lewis V, Guégan C, Romero N, Chen C, Dubois-Dauphin M, Przedborski S. Delaying caspase activation by Bcl-2: A clue to disease retardation in a transgenic mouse model of amyotrophic lateral sclerosis Journal of Neuroscience. 20: 9119-9125. PMID 11124989 DOI: 10.1523/Jneurosci.20-24-09119.2000  0.398
2000 Jackson-Lewis V, Vila M, Djaldetti R, Guegan C, Liberatore G, Liu J, O'Malley KL, Burke RE, Przedborski S. Developmental cell death in dopaminergic neurons of the substantia nigra of mice. The Journal of Comparative Neurology. 424: 476-88. PMID 10906714 DOI: 10.1002/1096-9861(20000828)424:3<476::Aid-Cne6>3.0.Co;2-0  0.389
2000 Przedborski S, Vila M, Jackson-Lewis V, Dawson TM. Reply: a new look at the pathogenesis of Parkinson's disease Trends in Pharmacological Sciences. 21: 165. PMID 10785645 DOI: 10.1016/S0165-6147(00)01470-X  0.47
2000 Li M, Ona VO, Guégan C, Chen M, Jackson-Lewis V, Andrews LJ, Olszewski AJ, Stieg PE, Lee JP, Przedborski S, Friedlander RM. Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model. Science (New York, N.Y.). 288: 335-9. PMID 10764647 DOI: 10.1126/Science.288.5464.335  0.375
2000 Vila M, Vukosavic S, Jackson-Lewis V, Neystat M, Jakowec M, Przedborski S. α-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP Journal of Neurochemistry. 74: 721-729. PMID 10646524 DOI: 10.1046/J.1471-4159.2000.740721.X  0.426
1999 Vukosavic S, Dubois-Dauphin M, Romero N, Przedborski S. Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis Journal of Neurochemistry. 73: 2460-2468. PMID 10582606 DOI: 10.1046/J.1471-4159.1999.0732460.X  0.365
1999 Donovan DM, Miner LL, Perry MP, Revay RS, Sharpe LG, Przedborski S, Kostic V, Philpot RM, Kirstein CL, Rothman RB, Schindler CW, Uhl GR. Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression. Brain Research. Molecular Brain Research. 73: 37-49. PMID 10581396 DOI: 10.1016/S0169-328X(99)00235-1  0.317
1999 Liberatore GT, Jackson-Lewis V, Vukosavic S, Mandir AS, Vila M, McAuliffe WG, Dawson VL, Dawson TM, Przedborski S. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nature Medicine. 5: 1403-9. PMID 10581083 DOI: 10.1038/70978  0.415
1999 Pennathur S, Jackson-Lewis V, Przedborski S, Heinecke JW. Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o'-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson's disease. The Journal of Biological Chemistry. 274: 34621-8. PMID 10574926 DOI: 10.1074/Jbc.274.49.34621  0.335
1999 Kostic VS, Svetel M, Sternic N, Dragasevic N, Przedborski S. Theophylline increases 'on' time in advanced parkinsonian patients Neurology. 52: 1916. PMID 10371549 DOI: 10.1212/Wnl.52.9.1916  0.341
1999 Almer G, Vukosavic S, Romero N, Przedborski S. Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis Journal of Neurochemistry. 72: 2415-2425. PMID 10349851 DOI: 10.1046/J.1471-4159.1999.0722415.X  0.376
1999 Mandir AS, Przedborski S, Jackson-Lewis V, Wang ZQ, Simbulan-Rosenthal CM, Smulson ME, Hoffman BE, Guastella DB, Dawson VL, Dawson TM. Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism. Proceedings of the National Academy of Sciences of the United States of America. 96: 5774-9. PMID 10318960 DOI: 10.1073/Pnas.96.10.5774  0.313
1998 Przedborski S, Jackson-Lewis V. Experimental developments in movement disorders: Update on proposed free radical mechanisms Current Opinion in Neurology. 11: 335-339. PMID 9725079 DOI: 10.1097/00019052-199808000-00009  0.341
1998 Ara J, Przedborski S, Naini AB, Jackson-Lewis V, Trifiletti RR, Horwitz J, Ischiropoulos H. Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Proceedings of the National Academy of Sciences of the United States of America. 95: 7659-63. PMID 9636206 DOI: 10.1073/Pnas.95.13.7659  0.366
1997 Takahashi N, Miner LL, Sora I, Ujike H, Revay RS, Kostic V, Jackson-Lewis V, Przedborski S, Uhl GR. VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity. Proceedings of the National Academy of Sciences of the United States of America. 94: 9938-43. PMID 9275230 DOI: 10.1073/Pnas.94.18.9938  0.31
1997 Kostic V, Jackson-Lewis V, De Bilbao F, Dubois-Dauphin M, Przedborski S. Bcl-2: Prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis Science. 277: 559-562. PMID 9228005 DOI: 10.1126/Science.277.5325.559  0.408
1997 Mena MA, Khan U, Togasaki DM, Sulzer D, Epstein CJ, Przedborski S. Effects of wild-type and mutated copper/zinc superoxide dismutase on neuronal survival and L-DOPA-induced toxicity in postnatal midbrain culture. Journal of Neurochemistry. 69: 21-33. PMID 9202290 DOI: 10.1046/J.1471-4159.1997.69010021.X  0.342
1997 Kostic V, Gurney ME, Deng HX, Siddique T, Epstein CJ, Przedborski S. Midbrain dopaminergic neuronal degeneration in a transgenic mouse model of familial amyotrophic lateral sclerosis. Annals of Neurology. 41: 497-504. PMID 9124807 DOI: 10.1002/Ana.410410413  0.398
1996 Przedborski S, Donaldson D, Jakowec M, Kish SJ, Guttman M, Rosoklija G, Hays AP. Brain superoxide dismutase, catalase, and glutathione peroxidase activities in amyotrophic lateral sclerosis. Annals of Neurology. 39: 158-65. PMID 8967746 DOI: 10.1002/Ana.410390204  0.326
1996 Przedborski S, Dhawan V, Donaldson DM, Murphy PL, McKenna-Yasek D, Mandel FS, Brown RH, Eidelberg D. Nigrostriatal dopaminergic function in familial amyotrophic lateral sclerosis patients with and without copper/zinc superoxide dismutase mutations. Neurology. 47: 1546-51. PMID 8960743 DOI: 10.1212/Wnl.47.6.1546  0.348
1996 Przedborski S, Khan U, Kostic V, Carlson E, Epstein CJ, Sulzer D. Increased superoxide dismutase activity improves survival of cultured postnatal midbrain neurons. Journal of Neurochemistry. 67: 1383-92. PMID 8858919 DOI: 10.1046/J.1471-4159.1996.67041383.X  0.319
1996 Przedborski S, Donaldson DM, Murphy PL, Hirsch O, Lange D, Naini AB, McKenna-Yasek D, Brown RH. Blood superoxide dismutase, catalase and glutathione peroxidase activities in familial and sporadic amyotrophic lateral sclerosis. Neurodegeneration : a Journal For Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration. 5: 57-64. PMID 8731383 DOI: 10.1006/Neur.1996.0008  0.33
1996 Przedborski S, Jackson-Lewis V, Yokoyama R, Shibata T, Dawson VL, Dawson TM. Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 93: 4565-71. PMID 8643444 DOI: 10.1073/Pnas.93.10.4565  0.417
1995 Levivier M, Przedborski S, Bencsics C, Kang UJ. Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease Journal of Neuroscience. 15: 7810-7820. PMID 8613721  0.304
1995 Jackson-Lewis V, Jakowec M, Burke RE, Przedborski S. Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neurodegeneration : a Journal For Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration. 4: 257-69. PMID 8581558 DOI: 10.1016/1055-8330(95)90015-2  0.384
1995 Przedborski S, Jackson-Lewis V, Fahn S. Antiparkinsonian therapies and brain mitochondrial complex I activity. Movement Disorders : Official Journal of the Movement Disorder Society. 10: 312-7. PMID 7651449 DOI: 10.1002/Mds.870100314  0.339
1994 Eidelberg D, Moeller JR, Dhawan V, Spetsieris P, Takikawa S, Ishikawa T, Chaly T, Robeson W, Margouleff D, Przedborski S. The metabolic topography of parkinsonism. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 14: 783-801. PMID 8063874 DOI: 10.1038/Jcbfm.1994.99  0.311
1994 Muthane U, Ramsay KA, Jiang H, Jackson-Lewis V, Donaldson D, Fernando S, Ferreira M, Przedborski S. Differences in nigral neuron number and sensitivity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57/bl and CD-1 mice. Experimental Neurology. 126: 195-204. PMID 7925820 DOI: 10.1006/Exnr.1994.1058  0.341
1993 Przedborski S, Jackson-Lewis V, Muthane U, Jiang H, Ferreira M, Naini AB, Fahn S. Chronic levodopa administration alters cerebral mitochondrial respiratory chain activity. Annals of Neurology. 34: 715-23. PMID 8239566 DOI: 10.1002/Ana.410340515  0.359
1992 Giladi N, McMahon D, Przedborski S, Flaster E, Guillory S, Kostic V, Fahn S. Motor blocks in Parkinson's disease. Neurology. 42: 333-9. PMID 1736161 DOI: 10.1212/Wnl.42.2.333  0.366
1992 Przedborski S, Kostic V, Jackson-Lewis V, Naini AB, Simonetti S, Fahn S, Carlson E, Epstein CJ, Cadet JL. Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 1658-67. PMID 1578260 DOI: 10.1523/Jneurosci.12-05-01658.1992  0.391
1991 Kostic V, Przedborski S, Flaster E, Sternic N. Early development of levodopa-induced dyskinesias and response fluctuations in young-onset Parkinson's disease. Neurology. 41: 202-202. PMID 1992362 DOI: 10.1212/Wnl.41.2_Part_1.202  0.322
1991 Przedborski S, Levivier M, Kostic V, Jackson-Lewis V, Dollison A, Gash DM, Fahn S, Cadet JL. Sham transplantation protects against 6-hydroxydopamine-induced dopaminergic toxicity in rats: behavioral and morphological evidence. Brain Research. 550: 231-8. PMID 1832076 DOI: 10.1016/0006-8993(91)91323-S  0.328
1991 Cadet JL, Kujirai K, Przedborski S. Bilateral modulation of [3H]neurotensin binding by unilateral intrastriatal 6-hydroxydopamine injections: evidence from a receptor autoradiographic study. Brain Research. 564: 37-44. PMID 1663814 DOI: 10.1016/0006-8993(91)91349-6  0.302
1990 Cadet JL, Przedborski S, Kostic V, Jackson-Lewis V, Carlson E, Epstein CJ. Quantitative autoradiographic distribution of [3H]mazindol-labeled dopamine uptake sites in the brains of superoxide dismutase transgenic mice. Brain Research Bulletin. 25: 187-92. PMID 2119856 DOI: 10.1016/0361-9230(90)90274-4  0.344
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