Serge Przedborski, Md - Publications

Affiliations: 
Columbia University, New York, NY 
Area:
Neurodegeneration, Neurobiology of Disease, Molecular and Cellular Biology of Neurodegeneration, Parkinson's Disease, Motor Neuron Biology and Diseases, Amyotrophic Lateral Sclerosis, Mitochondria Biology and Disease, Mitophagy, Neuroinflammation, Microgl

192 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Ji R, Smith M, Niimi Y, Karakatsani ME, Murillo MF, Jackson-Lewis V, Przedborski S, Konofagou EE. Focused ultrasound enhanced intranasal delivery of brain derived neurotrophic factor produces neurorestorative effects in a Parkinson's disease mouse model. Scientific Reports. 9: 19402. PMID 31852909 DOI: 10.1038/s41598-019-55294-5  0.32
2019 Karakatsani ME, Wang S, Samiotaki G, Kugelman T, Olumolade OO, Acosta C, Sun T, Han Y, Kamimura HAS, Jackson-Lewis V, Przedborski S, Konofagou E. Amelioration of the nigrostriatal pathway facilitated by ultrasound-mediated neurotrophic delivery in early Parkinson's disease. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 30953664 DOI: 10.1016/j.jconrel.2019.03.030  0.32
2018 Antoniou N, Vlachakis D, Memou A, Leandrou E, Valkimadi PE, Melachroinou K, Re DB, Przedborski S, Dauer WT, Stefanis L, Rideout HJ. A motif within the armadillo repeat of Parkinson's-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway. Scientific Reports. 8: 3455. PMID 29472595 DOI: 10.1038/s41598-018-21931-8  0.32
2015 Brichta L, Shin W, Jackson-Lewis V, Blesa J, Yap EL, Walker Z, Zhang J, Roussarie JP, Alvarez MJ, Califano A, Przedborski S, Greengard P. Identification of neurodegenerative factors using translatome-regulatory network analysis. Nature Neuroscience. PMID 26214373 DOI: 10.1038/nn.4070  0.84
2015 Ikiz B, Alvarez MJ, Ré DB, Le Verche V, Politi K, Lotti F, Phani S, Pradhan R, Yu C, Croft GF, Jacquier A, Henderson CE, Califano A, Przedborski S. The Regulatory Machinery of Neurodegeneration in In Vitro Models of Amyotrophic Lateral Sclerosis. Cell Reports. 12: 335-45. PMID 26146077 DOI: 10.1016/j.celrep.2015.06.019  0.84
2015 Dehay B, Bourdenx M, Gorry P, Przedborski S, Vila M, Hunot S, Singleton A, Olanow CW, Merchant KM, Bezard E, Petsko GA, Meissner WG. Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations. The Lancet. Neurology. PMID 26050140 DOI: 10.1016/S1474-4422(15)00006-X  0.84
2015 Guardia-Laguarta C, Area-Gomez E, Schon EA, Przedborski S. A new role for α-synuclein in Parkinson's disease: Alteration of ER-mitochondrial communication. Movement Disorders : Official Journal of the Movement Disorder Society. 30: 1026-33. PMID 25952565 DOI: 10.1002/mds.26239  0.84
2015 Kett LR, Stiller B, Bernath MM, Tasset I, Blesa J, Jackson-Lewis V, Chan RB, Zhou B, Di Paolo G, Przedborski S, Cuervo AM, Dauer WT. α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 5724-42. PMID 25855184 DOI: 10.1523/JNEUROSCI.0632-14.2015  0.84
2015 Guardia-Laguarta C, Area-Gomez E, Schon EA, Przedborski S. Novel subcellular localization for α-synuclein: possible functional consequences. Frontiers in Neuroanatomy. 9: 17. PMID 25755636 DOI: 10.3389/fnana.2015.00017  0.84
2014 Blesa J, Przedborski S. Parkinson's disease: animal models and dopaminergic cell vulnerability. Frontiers in Neuroanatomy. 8: 155. PMID 25565980 DOI: 10.3389/fnana.2014.00155  0.84
2014 Le Masson G, Przedborski S, Abbott LF. A computational model of motor neuron degeneration. Neuron. 83: 975-88. PMID 25088365 DOI: 10.1016/j.neuron.2014.07.001  0.84
2014 Re DB, Le Verche V, Yu C, Amoroso MW, Politi KA, Phani S, Ikiz B, Hoffmann L, Koolen M, Nagata T, Papadimitriou D, Nagy P, Mitsumoto H, Kariya S, Wichterle H, ... ... Przedborski S, et al. Necroptosis drives motor neuron death in models of both sporadic and familial ALS. Neuron. 81: 1001-8. PMID 24508385 DOI: 10.1016/j.neuron.2014.01.011  0.84
2014 Guardia-Laguarta C, Area-Gomez E, Rüb C, Liu Y, Magrané J, Becker D, Voos W, Schon EA, Przedborski S. α-Synuclein is localized to mitochondria-associated ER membranes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 249-59. PMID 24381286 DOI: 10.1523/JNEUROSCI.2507-13.2014  0.84
2014 Fedorowicz MA, de Vries-Schneider RL, Rüb C, Becker D, Huang Y, Zhou C, Alessi Wolken DM, Voos W, Liu Y, Przedborski S. Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy. Embo Reports. 15: 86-93. PMID 24357652 DOI: 10.1002/embr.201337294  0.84
2014 Ikiz B, Alvarez MJ, Ré DB, LeVerche V, Politi K, Lotti F, Phani S, Pradhan R, Yu C, Croft GF, Jacquier A, Henderson CE, Califano A, Przedborski S. The Regulatory Machinery of Neurodegeneration in InVitro Models of Amyotrophic Lateral Sclerosis Cell Reports. DOI: 10.1016/j.celrep.2015.06.019  0.84
2014 Jackson-Lewis V, Lester D, Kozina E, Przedborski S, Smeyne RJ. From Man to Mouse: The MPTP Model of Parkinson Disease Movement Disorders: Genetics and Models: Second Edition. 287-306. DOI: 10.1016/B978-0-12-405195-9.00017-2  0.84
2013 Roybon L, Lamas NJ, Garcia-Diaz A, Yang EJ, Sattler R, Jackson-Lewis V, Kim YA, Kachel CA, Rothstein JD, Przedborski S, Wichterle H, Henderson CE. Human stem cell-derived spinal cord astrocytes with defined mature or reactive phenotypes. Cell Reports. 4: 1035-48. PMID 23994478 DOI: 10.1016/j.celrep.2013.06.021  0.84
2013 Ravits J, Appel S, Baloh RH, Barohn R, Brooks BR, Elman L, Floeter MK, Henderson C, Lomen-Hoerth C, Macklis JD, McCluskey L, Mitsumoto H, Przedborski S, Rothstein J, Trojanowski JQ, et al. Deciphering amyotrophic lateral sclerosis: what phenotype, neuropathology and genetics are telling us about pathogenesis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 14: 5-18. PMID 23678876 DOI: 10.3109/21678421.2013.778548  0.84
2013 Di Paolo G, Przedborski S. When Schwann cells conspire with mitochondria, neighboring axons are under attack by glia-derived neurotoxic lipids. Neuron. 77: 801-3. PMID 23473310 DOI: 10.1016/j.neuron.2013.02.016  0.84
2013 Hirsch EC, Jenner P, Przedborski S. Pathogenesis of Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 28: 24-30. PMID 22927094 DOI: 10.1002/mds.25032  0.84
2013 de Vries RL, Przedborski S. Mitophagy and Parkinson's disease: be eaten to stay healthy. Molecular and Cellular Neurosciences. 55: 37-43. PMID 22926193 DOI: 10.1016/j.mcn.2012.07.008  0.84
2012 Teng YD, Benn SC, Kalkanis SN, Shefner JM, Onario RC, Cheng B, Lachyankar MB, Marconi M, Li J, Yu D, Han I, Maragakis NJ, Lládo J, Erkmen K, Redmond DE, ... ... Przedborski S, et al. Multimodal actions of neural stem cells in a mouse model of ALS: a meta-analysis. Science Translational Medicine. 4: 165ra164. PMID 23253611 DOI: 10.1126/scitranslmed.3004579  0.84
2012 Phani S, Re DB, Przedborski S. The Role of the Innate Immune System in ALS. Frontiers in Pharmacology. 3: 150. PMID 22912616 DOI: 10.3389/fphar.2012.00150  0.84
2012 Gonzalez-Reyes LE, Verbitsky M, Blesa J, Jackson-Lewis V, Paredes D, Tillack K, Phani S, Kramer ER, Przedborski S, Kottmann AH. Sonic hedgehog maintains cellular and neurochemical homeostasis in the adult nigrostriatal circuit. Neuron. 75: 306-19. PMID 22841315 DOI: 10.1016/j.neuron.2012.05.018  0.84
2012 Cooper O, Seo H, Andrabi S, Guardia-Laguarta C, Graziotto J, Sundberg M, McLean JR, Carrillo-Reid L, Xie Z, Osborn T, Hargus G, Deleidi M, Lawson T, Bogetofte H, Perez-Torres E, ... ... Przedborski S, et al. Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Science Translational Medicine. 4: 141ra90. PMID 22764206 DOI: 10.1126/scitranslmed.3003985  0.84
2012 Kariya S, Re DB, Jacquier A, Nelson K, Przedborski S, Monani UR. Mutant superoxide dismutase 1 (SOD1), a cause of amyotrophic lateral sclerosis, disrupts the recruitment of SMN, the spinal muscular atrophy protein to nuclear cajal bodies Human Molecular Genetics. 21: 3421-3434. PMID 22581780 DOI: 10.1093/hmg/dds174  0.84
2012 Becker D, Richter J, Tocilescu MA, Przedborski S, Voos W. Pink1 kinase and its membrane potential (Deltaψ)-dependent cleavage product both localize to outer mitochondrial membrane by unique targeting mode. The Journal of Biological Chemistry. 287: 22969-87. PMID 22547060 DOI: 10.1074/jbc.M112.365700  0.84
2012 Blesa J, Phani S, Jackson-Lewis V, Przedborski S. Classic and new animal models of Parkinson's disease. Journal of Biomedicine & Biotechnology. 2012: 845618. PMID 22536024 DOI: 10.1155/2012/845618  0.84
2012 de Vries RL, Gilkerson RW, Przedborski S, Schon EA. Mitophagy in cells with mtDNA mutations: being sick is not enough. Autophagy. 8: 699-700. PMID 22361618 DOI: 10.4161/auto.19470  0.84
2012 Magrané J, Sahawneh MA, Przedborski S, Estévez ÁG, Manfredi G. Mitochondrial dynamics and bioenergetic dysfunction is associated with synaptic alterations in mutant SOD1 motor neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 229-42. PMID 22219285 DOI: 10.1523/JNEUROSCI.1233-11.2012  0.84
2012 Phani S, Loike JD, Przedborski S. Neurodegeneration and inflammation in Parkinson's disease. Parkinsonism & Related Disorders. 18: S207-9. PMID 22166436 DOI: 10.1016/S1353-8020(11)70064-5  0.32
2012 Jackson-Lewis V, Blesa J, Przedborski S. Animal models of Parkinson's disease. Parkinsonism & Related Disorders. 18: S183-5. PMID 22166429 DOI: 10.1016/S1353-8020(11)70057-8  0.84
2012 Gilkerson RW, De Vries RL, Lebot P, Wikstrom JD, Torgyekes E, Shirihai OS, Przedborski S, Schon EA. Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition. Human Molecular Genetics. 21: 978-90. PMID 22080835 DOI: 10.1093/hmg/ddr529  0.84
2012 Lim L, Jackson-Lewis V, Wong LC, Shui GH, Goh AX, Kesavapany S, Jenner AM, Fivaz M, Przedborski S, Wenk MR. Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease. Cell Death and Differentiation. 19: 416-27. PMID 21818119 DOI: 10.1038/cdd.2011.105  0.84
2011 Przedborski S. Can we reverse alpha-synuclein lesions? Movement Disorders : Official Journal of the Movement Disorder Society. 26: 1618. PMID 21938768 DOI: 10.1002/mds.23902  0.84
2011 Lim S, Chesser AS, Grima JC, Rappold PM, Blum D, Przedborski S, Tieu K. D-β-hydroxybutyrate is protective in mouse models of Huntington's disease. Plos One. 6: e24620. PMID 21931779 DOI: 10.1371/journal.pone.0024620  0.84
2011 Schon EA, Przedborski S. Mitochondria: the next (neurode)generation. Neuron. 70: 1033-53. PMID 21689593 DOI: 10.1016/j.neuron.2011.06.003  0.84
2011 Bezard E, Przedborski S. A tale on animal models of Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 26: 993-1002. PMID 21626544 DOI: 10.1002/mds.23696  0.84
2011 Vives-Bauza C, Przedborski S. Mitophagy: the latest problem for Parkinson's disease. Trends in Molecular Medicine. 17: 158-65. PMID 21146459 DOI: 10.1016/j.molmed.2010.11.002  0.84
2011 Zhang W, Phillips K, Wielgus AR, Liu J, Albertini A, Zucca FA, Faust R, Qian SY, Miller DS, Chignell CF, Wilson B, Jackson-Lewis V, Przedborski S, Joset D, Loike J, et al. Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease. Neurotoxicity Research. 19: 63-72. PMID 19957214 DOI: 10.1007/s12640-009-9140-z  0.84
2011 le Verche V, Ikiz B, Jacquier A, Przedborski S, Re DB. Glutamate pathway implication in amyotrophic lateral sclerosis: What is the signal in the noise? Journal of Receptor, Ligand and Channel Research. 4: 1-22. DOI: 10.2147/JRLCR.S6504  0.84
2010 Le Verche V, Przedborski S. Is amyotrophic lateral sclerosis a mitochondrial channelopathy? Neuron. 67: 523-4. PMID 20797528 DOI: 10.1016/j.neuron.2010.08.010  0.84
2010 Vives-Bauza C, Tocilescu M, Devries RL, Alessi DM, Jackson-Lewis V, Przedborski S. Control of mitochondrial integrity in Parkinson's disease. Progress in Brain Research. 183: 99-113. PMID 20696317 DOI: 10.1016/S0079-6123(10)83006-7  0.84
2010 Perier C, Bové J, Dehay B, Jackson-Lewis V, Rabinovitch PS, Przedborski S, Vila M. Apoptosis-inducing factor deficiency sensitizes dopaminergic neurons to parkinsonian neurotoxins. Annals of Neurology. 68: 184-92. PMID 20695011 DOI: 10.1002/ana.22034  0.84
2010 Wichterle H, Przedborski S. What can pluripotent stem cells teach us about neurodegenerative diseases? Nature Neuroscience. 13: 800-4. PMID 20581816 DOI: 10.1038/nn.2577  0.84
2010 Vives-Bauza C, Przedborski S. PINK1 points Parkin to mitochondria. Autophagy. 6: 674-5. PMID 20484984 DOI: 10.4161/auto.6.5.12068  0.84
2010 Vives-Bauza C, de Vries RL, Tocilescu M, Przedborski S. PINK1/Parkin direct mitochondria to autophagy. Autophagy. 6: 315-6. PMID 20200476 DOI: 10.4161/auto.6.2.11199  0.84
2010 Przedborski S. Inflammation and Parkinson's disease pathogenesis. Movement Disorders : Official Journal of the Movement Disorder Society. 25: S55-7. PMID 20187228 DOI: 10.1002/mds.22638  0.84
2010 Dickson DW, Uchikado H, Fujishiro H, Tsuboi Y. Evidence in favor of Braak staging of Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 25: S78-82. PMID 20187227 DOI: 10.1002/mds.22637  0.84
2010 Malagelada C, Jin ZH, Jackson-Lewis V, Przedborski S, Greene LA. Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 1166-75. PMID 20089925 DOI: 10.1523/JNEUROSCI.3944-09.2010  0.84
2010 Vives-Bauza C, Zhou C, Huang Y, Cui M, de Vries RL, Kim J, May J, Tocilescu MA, Liu W, Ko HS, Magrané J, Moore DJ, Dawson VL, Grailhe R, Dawson TM, ... ... Przedborski S, et al. PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proceedings of the National Academy of Sciences of the United States of America. 107: 378-83. PMID 19966284 DOI: 10.1073/pnas.0911187107  0.84
2010 Papadimitriou D, Le Verche V, Jacquier A, Ikiz B, Przedborski S, Re DB. Inflammation in ALS and SMA: Sorting out the good from the evil Neurobiology of Disease. 37: 493-502. PMID 19833209 DOI: 10.1016/j.nbd.2009.10.005  0.84
2009 Vives-Bauza C, de Vries RL, Tocilescu MA, Przedborski S. Is there a pathogenic role for mitochondria in Parkinson's disease? Parkinsonism & Related Disorders. 15: S241-4. PMID 20083000 DOI: 10.1016/S1353-8020(09)70823-5  0.84
2009 Hoang T, Choi DK, Nagai M, Wu DC, Nagata T, Prou D, Wilson GL, Vila M, Jackson-Lewis V, Dawson VL, Dawson TM, Chesselet MF, Przedborski S. Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson disease. Free Radical Biology & Medicine. 47: 1049-56. PMID 19616617 DOI: 10.1016/j.freeradbiomed.2009.07.013  0.84
2009 Li Y, Liu W, Oo TF, Wang L, Tang Y, Jackson-Lewis V, Zhou C, Geghman K, Bogdanov M, Przedborski S, Beal MF, Burke RE, Li C. Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nature Neuroscience. 12: 826-8. PMID 19503083 DOI: 10.1038/nn.2349  0.84
2009 Cui M, Aras R, Christian WV, Rappold PM, Hatwar M, Panza J, Jackson-Lewis V, Javitch JA, Ballatori N, Przedborski S, Tieu K. The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway. Proceedings of the National Academy of Sciences of the United States of America. 106: 8043-8. PMID 19416912 DOI: 10.1073/pnas.0900358106  0.84
2009 Zhou C, Przedborski S. Intrabody and Parkinson's disease. Biochimica Et Biophysica Acta. 1792: 634-42. PMID 18834937 DOI: 10.1016/j.bbadis.2008.09.001  0.84
2008 Ikiz B, Przedborski S. A sequel to the tale of p25/Cdk5 in neurodegeneration. Neuron. 60: 731-2. PMID 19081365 DOI: 10.1016/j.neuron.2008.11.020  0.84
2008 Zhou C, Huang Y, Przedborski S. Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance. Annals of the New York Academy of Sciences. 1147: 93-104. PMID 19076434 DOI: 10.1196/annals.1427.023  0.84
2008 Zhou C, Huang Y, Shao Y, May J, Prou D, Perier C, Dauer W, Schon EA, Przedborski S. The kinase domain of mitochondrial PINK1 faces the cytoplasm. Proceedings of the National Academy of Sciences of the United States of America. 105: 12022-7. PMID 18687899 DOI: 10.1073/pnas.0802814105  0.84
2008 Banerjee R, Mosley RL, Reynolds AD, Dhar A, Jackson-Lewis V, Gordon PH, Przedborski S, Gendelman HE. Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice. Plos One. 3: e2740. PMID 18648532 DOI: 10.1371/journal.pone.0002740  0.84
2008 Martinez-Vicente M, Talloczy Z, Kaushik S, Massey AC, Mazzulli J, Mosharov EV, Hodara R, Fredenburg R, Wu DC, Follenzi A, Dauer W, Przedborski S, Ischiropoulos H, Lansbury PT, Sulzer D, et al. Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. The Journal of Clinical Investigation. 118: 777-88. PMID 18172548 DOI: 10.1172/JCI32806  0.84
2008 Benner EJ, Banerjee R, Reynolds AD, Sherman S, Pisarev VM, Tsiperson V, Nemachek C, Ciborowski P, Przedborski S, Mosley RL, Gendelman HE. Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons. Plos One. 3: e1376. PMID 18167537 DOI: 10.1371/journal.pone.0001376  0.84
2008 Jackson-Lewis V, Przedborski S. The MPTP Mouse Model of Parkinson's Disease: The True, the False, and the Unknown Parkinson's Disease. 147-158. DOI: 10.1016/B978-0-12-374028-1.00011-7  0.84
2007 Przedborski S. Neuroinflammation and Parkinson's disease. Handbook of Clinical Neurology. 83: 535-51. PMID 18808933 DOI: 10.1016/S0072-9752(07)83026-0  0.84
2007 Andres-Mateos E, Perier C, Zhang L, Blanchard-Fillion B, Greco TM, Thomas B, Ko HS, Sasaki M, Ischiropoulos H, Przedborski S, Dawson TM, Dawson VL. DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proceedings of the National Academy of Sciences of the United States of America. 104: 14807-12. PMID 17766438 DOI: 10.1073/pnas.0703219104  0.84
2007 Przedborski S. Peroxiredoxin-2 links Cdk5 to neurodegeneration. Nature Medicine. 13: 907-9. PMID 17680003 DOI: 10.1038/nm0807-907  0.84
2007 Perier C, Bové J, Wu DC, Dehay B, Choi DK, Jackson-Lewis V, Rathke-Hartlieb S, Bouillet P, Strasser A, Schulz JB, Przedborski S, Vila M. Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 104: 8161-6. PMID 17483459 DOI: 10.1073/pnas.0609874104  0.84
2007 Nagai M, Re DB, Nagata T, Chalazonitis A, Jessell TM, Wichterle H, Przedborski S. Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons. Nature Neuroscience. 10: 615-22. PMID 17435755 DOI: 10.1038/nn1876  0.84
2007 Jackson-Lewis V, Przedborski S. Protocol for the MPTP mouse model of Parkinson's disease. Nature Protocols. 2: 141-51. PMID 17401348 DOI: 10.1038/nprot.2006.342  0.84
2007 Whittle AJ, Ross OA, Naini A, Gordon P, Mistumoto H, Dächsel JC, Stone JT, Wszolek ZK, Farrer MJ, Przedborski S. Pathogenic Lrrk2 substitutions and Amyotrophic lateral sclerosis. Journal of Neural Transmission (Vienna, Austria : 1996). 114: 327-9. PMID 16865326 DOI: 10.1007/s00702-006-0525-3  0.84
2007 Nagai M, Murakami T, Ohta Y, Takehisa Y, Morimoto N, Miyazaki K, Kurata T, Kamiya T, Abe K, Przedborski S. Dysfunction of mitochondrial oxidative phosphorylation in als rat model Journal of Cerebral Blood Flow and Metabolism. 27: BP30-07U.  0.84
2006 Dhib-Jalbut S, Arnold DL, Cleveland DW, Fisher M, Friedlander RM, Mouradian MM, Przedborski S, Trapp BD, Wyss-Coray T, Yong VW. Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases. Journal of Neuroimmunology. 176: 198-215. PMID 16983747 DOI: 10.1016/j.jneuroim.2006.03.027  0.84
2006 Mosharov EV, Staal RG, Bové J, Prou D, Hananiya A, Markov D, Poulsen N, Larsen KE, Moore CM, Troyer MD, Edwards RH, Przedborski S, Sulzer D. Alpha-synuclein overexpression increases cytosolic catecholamine concentration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 9304-11. PMID 16957086 DOI: 10.1523/JNEUROSCI.0519-06.2006  0.84
2006 Wu DC, Ré DB, Nagai M, Ischiropoulos H, Przedborski S. The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice. Proceedings of the National Academy of Sciences of the United States of America. 103: 12132-7. PMID 16877542 DOI: 10.1073/pnas.0603670103  0.84
2006 Bové J, Zhou C, Jackson-Lewis V, Taylor J, Chu Y, Rideout HJ, Wu DC, Kordower JH, Petrucelli L, Przedborski S. Proteasome inhibition and Parkinson's disease modeling. Annals of Neurology. 60: 260-4. PMID 16862585 DOI: 10.1002/ana.20937  0.84
2006 Ré DB, Przedborski S. Fractalkine: moving from chemotaxis to neuroprotection. Nature Neuroscience. 9: 859-61. PMID 16801915 DOI: 10.1038/nn0706-859  0.84
2006 Blanchard-Fillion B, Prou D, Polydoro M, Spielberg D, Tsika E, Wang Z, Hazen SL, Koval M, Przedborski S, Ischiropoulos H. Metabolism of 3-nitrotyrosine induces apoptotic death in dopaminergic cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 6124-30. PMID 16763020 DOI: 10.1523/JNEUROSCI.1038-06.2006  0.84
2006 Almer G, Kikuchi H, Teismann P, Przedborski S. Is prostaglandin E(2) a pathogenic factor in amyotrophic lateral sclerosis? Annals of Neurology. 59: 980-3. PMID 16619237 DOI: 10.1002/ana.20847  0.84
2006 Gordon PH, Doorish C, Montes J, Mosley RL, Mosely RL, Diamond B, Macarthur RB, Weimer LH, Kaufmann P, Hays AP, Rowland LP, Gendelman HE, Przedborski S, Mitsumoto H. Randomized controlled phase II trial of glatiramer acetate in ALS. Neurology. 66: 1117-9. PMID 16606934 DOI: 10.1212/01.wnl.0000204235.81272.e2  0.84
2006 Kikuchi H, Almer G, Yamashita S, Guégan C, Nagai M, Xu Z, Sosunov AA, McKhann GM, Przedborski S. Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model. Proceedings of the National Academy of Sciences of the United States of America. 103: 6025-30. PMID 16595634 DOI: 10.1073/pnas.0509227103  0.84
2005 Bové J, Prou D, Perier C, Przedborski S. Toxin-induced models of Parkinson's disease. Neurorx : the Journal of the American Society For Experimental Neurotherapeutics. 2: 484-94. PMID 16389312 DOI: 10.1602/neurorx.2.3.484  0.84
2005 Perier C, Tieu K, Guégan C, Caspersen C, Jackson-Lewis V, Carelli V, Martinuzzi A, Hirano M, Przedborski S, Vila M. Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage. Proceedings of the National Academy of Sciences of the United States of America. 102: 19126-31. PMID 16365298 DOI: 10.1073/pnas.0508215102  0.84
2005 Li X, Rowland LP, Mitsumoto H, Przedborski S, Bird TD, Schellenberg GD, Peskind E, Johnson N, Siddique T, Mesulam MM, Weintraub S, Mastrianni JA. Prion protein codon 129 genotype prevalence is altered in primary progressive aphasia. Annals of Neurology. 58: 858-64. PMID 16315279 DOI: 10.1002/ana.20646  0.84
2005 Ved R, Saha S, Westlund B, Perier C, Burnam L, Sluder A, Hoener M, Rodrigues CM, Alfonso A, Steer C, Liu L, Przedborski S, Wolozin B. Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. The Journal of Biological Chemistry. 280: 42655-68. PMID 16239214 DOI: 10.1074/jbc.M505910200  0.84
2005 Silva RM, Ries V, Oo TF, Yarygina O, Jackson-Lewis V, Ryu EJ, Lu PD, Marciniak SJ, Ron D, Przedborski S, Kholodilov N, Greene LA, Burke RE. CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism. Journal of Neurochemistry. 95: 974-86. PMID 16135078 DOI: 10.1111/j.1471-4159.2005.03428.x  0.84
2005 Choi DK, Pennathur S, Perier C, Tieu K, Teismann P, Wu DC, Jackson-Lewis V, Vila M, Vonsattel JP, Heinecke JW, Przedborski S. Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 6594-600. PMID 16014720 DOI: 10.1523/JNEUROSCI.0970-05.2005  0.84
2005 Przedborski S, Ischiropoulos H. Reactive oxygen and nitrogen species: weapons of neuronal destruction in models of Parkinson's disease. Antioxidants & Redox Signaling. 7: 685-93. PMID 15890013 DOI: 10.1089/ars.2005.7.685  0.84
2005 Przedborski S. Pathogenesis of nigral cell death in Parkinson's disease. Parkinsonism & Related Disorders. 11: S3-7. PMID 15885625 DOI: 10.1016/j.parkreldis.2004.10.012  0.84
2005 Eriksen JL, Przedborski S, Petrucelli L. Gene dosage and pathogenesis of Parkinson's disease. Trends in Molecular Medicine. 11: 91-6. PMID 15760766 DOI: 10.1016/j.molmed.2005.01.001  0.84
2005 Przedborski S, Tieu K. Toxic animal models Neurodegenerative Diseases: Neurobiology, Pathogenesis and Therapeutics. 196-221. DOI: 10.1017/CBO9780511544873.017  0.84
2004 Przedborski S. Molecular targets for neuroprotection. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group On Motor Neuron Diseases. 5: 14-8. PMID 15512862 DOI: 10.1080/1734470410019780  0.84
2004 Mitsumoto H, Gordon P, Kaufmann P, Gooch CL, Przedborski S, Rowland LP. Randomized control trials in ALS: lessons learned. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group On Motor Neuron Diseases. 5: 8-13. PMID 15512861 DOI: 10.1080/17434470410019942  0.84
2004 Przedborski S, Tieu K, Perier C, Vila M. MPTP as a mitochondrial neurotoxic model of Parkinson's disease. Journal of Bioenergetics and Biomembranes. 36: 375-9. PMID 15377875 DOI: 10.1023/B:JOBB.0000041771.66775.d5  0.84
2004 Vila M, Przedborski S. Genetic clues to the pathogenesis of Parkinson's disease. Nature Medicine. 10: S58-62. PMID 15272270 DOI: 10.1038/nm1068  0.84
2004 Tieu K, Perier C, Vila M, Caspersen C, Zhang HP, Teismann P, Jackson-Lewis V, Stern DM, Yan SD, Przedborski S. L-3-hydroxyacyl-CoA dehydrogenase II protects in a model of Parkinson's disease. Annals of Neurology. 56: 51-60. PMID 15236401 DOI: 10.1002/ana.20133  0.84
2004 Benner EJ, Mosley RL, Destache CJ, Lewis TB, Jackson-Lewis V, Gorantla S, Nemachek C, Green SR, Przedborski S, Gendelman HE. Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 101: 9435-40. PMID 15197276 DOI: 10.1073/pnas.0400569101  0.84
2004 Hayley S, Crocker SJ, Smith PD, Shree T, Jackson-Lewis V, Przedborski S, Mount M, Slack R, Anisman H, Park DS. Regulation of dopaminergic loss by Fas in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2045-53. PMID 14985447 DOI: 10.1523/JNEUROSCI.4564-03.2004  0.84
2004 Przedborski S. Clarification: Pathogenic role of glial cells in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 19: 118. PMID 14743378 DOI: 10.1002/mds.10701  0.84
2004 Przedborski S. Programmed cell death in amyotrophic lateral sclerosis: a mechanism of pathogenic and therapeutic importance. The Neurologist. 10: 1-7. PMID 14720310 DOI: 10.1097/01.nrl.0000106920.84668.37  0.84
2004 Hunot S, Vila M, Teismann P, Davis RJ, Hirsch EC, Przedborski S, Rakic P, Flavell RA. JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 101: 665-70. PMID 14704277 DOI: 10.1073/pnas.0307453101  0.84
2004 Mitsumoto H, Przedborski S. Preface Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 5: 6-7. DOI: 10.1080/147434470410019951  0.84
2003 Bezard E, Dovero S, Belin D, Duconger S, Jackson-Lewis V, Przedborski S, Piazza PV, Gross CE, Jaber M. Enriched environment confers resistance to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and cocaine: involvement of dopamine transporter and trophic factors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 10999-1007. PMID 14657156  0.84
2003 Zhang Y, Ona VO, Li M, Drozda M, Dubois-Dauphin M, Przedborski S, Ferrante RJ, Friedlander RM. Sequential activation of individual caspases, and of alterations in Bcl-2 proapoptotic signals in a mouse model of Huntington's disease. Journal of Neurochemistry. 87: 1184-92. PMID 14622098 DOI: 10.1046/j.1471-4159.2003.02105.x  0.84
2003 Smith PD, Crocker SJ, Jackson-Lewis V, Jordan-Sciutto KL, Hayley S, Mount MP, O'Hare MJ, Callaghan S, Slack RS, Przedborski S, Anisman H, Park DS. Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 100: 13650-5. PMID 14595022 DOI: 10.1073/pnas.2232515100  0.84
2003 Tieu K, Perier C, Caspersen C, Teismann P, Wu DC, Yan SD, Naini A, Vila M, Jackson-Lewis V, Ramasamy R, Przedborski S. D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease. The Journal of Clinical Investigation. 112: 892-901. PMID 12975474 DOI: 10.1172/JCI18797  0.84
2003 Dauer W, Przedborski S. Parkinson's disease: mechanisms and models. Neuron. 39: 889-909. PMID 12971891 DOI: 10.1016/S0896-6273(03)00568-3  0.84
2003 Tieu K, Ischiropoulos H, Przedborski S. Nitric oxide and reactive oxygen species in Parkinson's disease. Iubmb Life. 55: 329-35. PMID 12938735 DOI: 10.1080/1521654032000114320  0.84
2003 Perier C, Bové J, Vila M, Przedborski S. The rotenone model of Parkinson's disease. Trends in Neurosciences. 26: 345-6. PMID 12850429 DOI: 10.1016/S0166-2236(03)00144-9  0.84
2003 Teismann P, Vila M, Choi DK, Tieu K, Wu DC, Jackson-Lewis V, Przedborski S. COX-2 and neurodegeneration in Parkinson's disease Annals of the New York Academy of Sciences. 991: 272-277. PMID 12846993 DOI: 10.1111/J.1749-6632.2003.TB07482.X  0.84
2003 Przedborski S, Vila M. The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson's disease. Annals of the New York Academy of Sciences. 991: 189-98. PMID 12846987  0.84
2003 Crocker SJ, Smith PD, Jackson-Lewis V, Lamba WR, Hayley SP, Grimm E, Callaghan SM, Slack RS, Melloni E, Przedborski S, Robertson GS, Anisman H, Merali Z, Park DS. Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4081-91. PMID 12764095  0.84
2003 Vila M, Przedborski S. Targeting programmed cell death in neurodegenerative diseases. Nature Reviews. Neuroscience. 4: 365-75. PMID 12728264 DOI: 10.1038/nrn1100  0.84
2003 Wu DC, Teismann P, Tieu K, Vila M, Jackson-Lewis V, Ischiropoulos H, Przedborski S. NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 100: 6145-50. PMID 12721370 DOI: 10.1073/pnas.0937239100  0.84
2003 Teismann P, Tieu K, Choi DK, Wu DC, Naini A, Hunot S, Vila M, Jackson-Lewis V, Przedborski S. Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. 100: 5473-8. PMID 12702778 DOI: 10.1073/pnas.0837397100  0.84
2003 Teismann P, Tieu K, Cohen O, Choi DK, Wu DC, Marks D, Vila M, Jackson-Lewis V, Przedborski S. Pathogenic role of glial cells in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 18: 121-9. PMID 12539204 DOI: 10.1002/mds.10332  0.84
2003 Przedborski S, Vila M, Jackson-Lewis V. Neurodegeneration: What is it and where are we? Journal of Clinical Investigation. 111: 3-10. PMID 12511579 DOI: 10.1172/JCI200317522  0.84
2003 Przedborski S, Mitsumoto H, Rowland LP. Recent advances in amyotrophic lateral sclerosis research. Current Neurology and Neuroscience Reports. 3: 70-7. PMID 12507415  0.84
2003 Przedborski S, Jackson-Lewis V, Vila M, Wu DC, Teismann P, Tieu K, Choi DK, Cohen O. Free radical and nitric oxide toxicity in Parkinson's disease Advances in Neurology. 91: 83-94. PMID 12442666  0.84
2003 Przedborski S, Clarke PGH. Chapter 14 Cell Death Pathways in Amyotrophic Lateral Sclerosis Blue Books of Practical Neurology. 28: 357-377. DOI: 10.1016/S1877-3419(09)70115-1  0.84
2002 Wu DC, Tieu K, Cohen O, Choi DK, Vila M, Jackson-Lewis V, Teismann P, Przedborski S. Glial cell response: A pathogenic factor in Parkinson's disease Journal of Neurovirology. 8: 551-558. PMID 12476349 DOI: 10.1080/13550280290100905  0.84
2002 Drachman DB, Frank K, Dykes-Hoberg M, Teismann P, Almer G, Przedborski S, Rothstein JD. Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS. Annals of Neurology. 52: 771-8. PMID 12447931 DOI: 10.1002/ana.10374  0.84
2002 Dauer W, Kholodilov N, Vila M, Trillat AC, Goodchild R, Larsen KE, Staal R, Tieu K, Schmitz Y, Yuan CA, Rocha M, Jackson-Lewis V, Hersch S, Sulzer D, Przedborski S, et al. Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP. Proceedings of the National Academy of Sciences of the United States of America. 99: 14524-9. PMID 12376616 DOI: 10.1073/pnas.172514599  0.32
2002 Guégan C, Vila M, Teismann P, Chen C, Onténiente B, Li M, Friedlander RM, Przedborski S, Teissman P. Instrumental activation of bid by caspase-1 in a transgenic mouse model of ALS. Molecular and Cellular Neurosciences. 20: 553-62. PMID 12213439 DOI: 10.1006/mcne.2002.1136  0.84
2002 Zhu S, Stavrovskaya IG, Drozda M, Kim BY, Ona V, Li M, Sarang S, Liu AS, Hartley DM, Wu DC, Gullans S, Ferrante RJ, Przedborski S, Kristal BS, Friedlander RM. Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature. 417: 74-8. PMID 11986668 DOI: 10.1038/417074a  0.84
2002 Almer G, Teismann P, Stevic Z, Halaschek-Wiener J, Deecke L, Kostic V, Przedborski S. Increased levels of the pro-inflammatory prostaglandin PGE2 in CSF from ALS patients Neurology. 58: 1277-1279. PMID 11971099  0.84
2002 Przedborski S, Jackson-Lewis V, Sulzer D, Naini A, Romero N, Chen C, Arias J. Transgenic superoxide dismutase overproducer: murine. Methods in Enzymology. 349: 180-90. PMID 11912908 DOI: 10.1016/S0076-6879(02)49334-2  0.84
2002 Wu DC, Jackson-Lewis V, Vila M, Tieu K, Teismann P, Vadseth C, Choi DK, Ischiropoulos H, Przedborski S. Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 1763-71. PMID 11880505  0.84
2002 Kostić VS, Marinković J, Svetel M, Stefanova E, Przedborski S. The effect of stage of Parkinson's disease at the onset of levodopa therapy on development of motor complications European Journal of Neurology. 9: 9-14. PMID 11784369 DOI: 10.1046/j.1468-1331.2002.00346.x  0.84
2001 Vila M, Wu DC, Przedborski S. Engineered modeling and the secrets of Parkinson's disease Trends in Neurosciences. 24: S49-55. PMID 11881746  0.84
2001 Feigin A, Fukuda M, Dhawan V, Przedborski S, Jackson-Lewis V, Mentis MJ, Moeller JR, Eidelberg D. Metabolic correlates of levodopa response in Parkinson's disease Neurology. 57: 2083-2088. PMID 11739830  0.84
2001 Petersén A, Hansson O, Puschban Z, Sapp E, Romero N, Castilho RF, Sulzer D, Rice M, DiFiglia M, Przedborski S, Brundin P. Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine. The European Journal of Neuroscience. 14: 1425-35. PMID 11722604 DOI: 10.1046/j.0953-816X.2001.01765.x  0.84
2001 Petersén A A, Larsen KE, Behr GG, Romero N, Przedborski S, Brundin P, Sulzer D. Brain-derived neurotrophic factor inhibits apoptosis and dopamine-induced free radical production in striatal neurons but does not prevent cell death. Brain Research Bulletin. 56: 331-5. PMID 11719268 DOI: 10.1016/S0361-9230(01)00580-9  0.84
2001 Blanchard-Fillion B, Souza JM, Friel T, Jiang GC, Vrana K, Sharov V, Barrón L, Schöneich C, Quijano C, Alvarez B, Radi R, Przedborski S, Fernando GS, Horwitz J, Ischiropoulos H. Nitration and inactivation of tyrosine hydroxylase by peroxynitrite. The Journal of Biological Chemistry. 276: 46017-23. PMID 11590168 DOI: 10.1074/jbc.M105564200  0.84
2001 Przedborski S, Vila M. The last decade in Parkinson's disease research. Basic sciences Advances in Neurology. 86: 177-186. PMID 11553976  0.84
2001 Guégan C, Vila M, Rosoklija G, Hays AP, Przedborski S. Recruitment of the mitochondrial-dependent apoptotic pathway in amyotrophic lateral sclerosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 6569-76. PMID 11517246  0.84
2001 Vila M, Jackson-Lewis V, Guégan C, Chu Wu D, Teismann P, Choi DK, Tieu K, Przedborski S. The role of glial cells in Parkinson's disease Current Opinion in Neurology. 14: 483-489. PMID 11470965 DOI: 10.1097/00019052-200108000-00009  0.84
2001 Matsuoka Y, Vila M, Lincoln S, McCormack A, Picciano M, LaFrancois J, Yu X, Dickson D, Langston WJ, McGowan E, Farrer M, Hardy J, Duff K, Przedborski S, Di Monte DA. Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter. Neurobiology of Disease. 8: 535-9. PMID 11442360 DOI: 10.1006/nbdi.2001.0392  0.84
2001 Giladi N, McDermott MP, Fahn S, Przedborski S, Jankovic J, Stern M, Tanner C. Freezing of gait in PD: prospective assessment in the DATATOP cohort. Neurology. 56: 1712-21. PMID 11425939 DOI: 10.1212/WNL.56.12.1712  0.84
2001 Petersén A, Larsen KE, Behr GG, Romero N, Przedborski S, Brundin P, Sulzer D. Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration. Human Molecular Genetics. 10: 1243-54. PMID 11406606 DOI: 10.1093/hmg/10.12.1243  0.84
2001 Przedborski S, Jackson-Lewis V, Naini AB, Jakowec M, Petzinger G, Miller R, Akram M. The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): A technical review of its utility and safety Journal of Neurochemistry. 76: 1265-1274. PMID 11238711 DOI: 10.1046/j.1471-4159.2001.00183.x  0.84
2001 Vila M, Jackson-Lewis V, Vukosavic S, Djaldetti R, Liberatore G, Offen D, Korsmeyer SJ, Przedborski S. Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease Proceedings of the National Academy of Sciences of the United States of America. 98: 2837-2842. PMID 11226327 DOI: 10.1073/pnas.051633998  0.84
2001 Almer G, Guégan C, Teismann P, Naini A, Rosoklija G, Hays AP, Chen C, Przedborski S. Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis. Annals of Neurology. 49: 176-85. PMID 11220737 DOI: 10.1002/1531-8249(20010201)49:2<176::AID-ANA37>3.0.CO;2-X  0.84
2001 Przedborski S, Chen Q, Vila M, Giasson BI, Djaldatti R, Vukosavic S, Souza JM, Jackson-Lewis V, Lee VM, Ischiropoulos H. Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. Journal of Neurochemistry. 76: 637-40. PMID 11208927 DOI: 10.1046/j.1471-4159.2001.00174.x  0.84
2001 Przedborski S, Vila M. MPTP: A review of its mechanisms of neurotoxicity Clinical Neuroscience Research. 1: 407-418. DOI: 10.1016/S1566-2772(01)00019-6  0.84
2000 Przedborski S, Jackson-Lewis V, Djaldetti R, Liberatore G, Vila M, Vukosavic S, Almer G. The parkinsonian toxin MPTP: action and mechanism. Restorative Neurology and Neuroscience. 16: 135-142. PMID 12671216  0.84
2000 Vukosavic S, Stefanis L, Jackson-Lewis V, Guégan C, Romero N, Chen C, Dubois-Dauphin M, Przedborski S. Delaying caspase activation by Bcl-2: A clue to disease retardation in a transgenic mouse model of amyotrophic lateral sclerosis Journal of Neuroscience. 20: 9119-9125. PMID 11124989  0.84
2000 Thyagarajan D, Bressman S, Bruno C, Przedborski S, Shanske S, Lynch T, Fahn S, DiMauro S. A novel mitochondrial 12SrRNA point mutation in parkinsonism, deafness, and neuropathy. Annals of Neurology. 48: 730-6. PMID 11079536 DOI: 10.1002/1531-8249(200011)48:5<730::AID-ANA6>3.0.CO;2-0  0.84
2000 Jackson-Lewis V, Vila M, Djaldetti R, Guegan C, Liberatore G, Liu J, O'Malley KL, Burke RE, Przedborski S. Developmental cell death in dopaminergic neurons of the substantia nigra of mice. The Journal of Comparative Neurology. 424: 476-88. PMID 10906714 DOI: 10.1002/1096-9861(20000828)424:3<476::AID-CNE6>3.0.CO;2-0  0.84
2000 Li M, Ona VO, Guégan C, Chen M, Jackson-Lewis V, Andrews LJ, Olszewski AJ, Stieg PE, Lee JP, Przedborski S, Friedlander RM. Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model. Science (New York, N.Y.). 288: 335-9. PMID 10764647 DOI: 10.1126/science.288.5464.335  0.84
2000 Vila M, Vukosavic S, Jackson-Lewis V, Neystat M, Jakowec M, Przedborski S. α-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP Journal of Neurochemistry. 74: 721-729. PMID 10646524 DOI: 10.1046/j.1471-4159.2000.740721.x  0.84
2000 Kostic VS, Przedborski S. Adenosine receptors and Parkinson's disease Focus On Parkinson's Disease. 12: 60-62.  0.84
1999 Vukosavic S, Dubois-Dauphin M, Romero N, Przedborski S. Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis Journal of Neurochemistry. 73: 2460-2468. PMID 10582606 DOI: 10.1046/j.1471-4159.1999.0732460.x  0.84
1999 Donovan DM, Miner LL, Perry MP, Revay RS, Sharpe LG, Przedborski S, Kostic V, Philpot RM, Kirstein CL, Rothman RB, Schindler CW, Uhl GR. Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression. Brain Research. Molecular Brain Research. 73: 37-49. PMID 10581396 DOI: 10.1016/S0169-328X(99)00235-1  0.84
1999 Liberatore GT, Jackson-Lewis V, Vukosavic S, Mandir AS, Vila M, McAuliffe WG, Dawson VL, Dawson TM, Przedborski S. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nature Medicine. 5: 1403-9. PMID 10581083 DOI: 10.1038/70978  0.84
1999 Pennathur S, Jackson-Lewis V, Przedborski S, Heinecke JW. Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o'-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson's disease. The Journal of Biological Chemistry. 274: 34621-8. PMID 10574926 DOI: 10.1074/jbc.274.49.34621  0.84
1999 Almer G, Rosoklija G, Hirano M, Hays AP, Przedborski S. Does increased superoxide dismutase activity really cause muscular dystrophy? Annals of Neurology. 46: 135. PMID 10401794  0.84
1999 Kostic VS, Svetel M, Sternic N, Dragasevic N, Przedborski S. Theophylline increases 'on' time in advanced parkinsonian patients Neurology. 52: 1916. PMID 10371549  0.84
1999 Almer G, Vukosavic S, Romero N, Przedborski S. Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis Journal of Neurochemistry. 72: 2415-2425. PMID 10349851 DOI: 10.1046/j.1471-4159.1999.0722415.x  0.84
1999 Neystat M, Lynch T, Przedborski S, Kholodilov N, Rzhetskaya M, Burke RE. Alpha-synuclein expression in substantia nigra and cortex in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 14: 417-22. PMID 10348463 DOI: 10.1002/1531-8257(199905)14:3<417::AID-MDS1005>3.0.CO;2-X  0.84
1999 Mandir AS, Przedborski S, Jackson-Lewis V, Wang ZQ, Simbulan-Rosenthal CM, Smulson ME, Hoffman BE, Guastella DB, Dawson VL, Dawson TM. Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism. Proceedings of the National Academy of Sciences of the United States of America. 96: 5774-9. PMID 10318960 DOI: 10.1073/pnas.96.10.5774  0.84
1998 Przedborski S, Jackson-Lewis V. Experimental developments in movement disorders: Update on proposed free radical mechanisms Current Opinion in Neurology. 11: 335-339. PMID 9725079 DOI: 10.1097/00019052-199808000-00009  0.84
1998 Sterneck E, Paylor R, Jackson-Lewis V, Libbey M, Przedborski S, Tessarollo L, Crawley JN, Johnson PF. Selectively enhanced contextual fear conditioning in mice lacking the transcriptional regulator CCAAT/enhancer binding protein delta. Proceedings of the National Academy of Sciences of the United States of America. 95: 10908-13. PMID 9724803 DOI: 10.1073/pnas.95.18.10908  0.84
1998 Kompoliti K, Goetz CG, Boeve BF, Maraganore DM, Ahlskog JE, Marsden CD, Bhatia KP, Greene PE, Przedborski S, Seal EC, Burns RS, Hauser RA, Gauger LL, Factor SA, Molho ES, et al. Clinical presentation and pharmacological therapy in corticobasal degeneration Archives of Neurology. 55: 957-961. PMID 9678313 DOI: 10.1001/archneur.55.7.957  0.84
1998 Pothos EN, Przedborski S, Davila V, Schmitz Y, Sulzer D. D2-Like dopamine autoreceptor activation reduces quantal size in PC12 cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 5575-85. PMID 9671649  0.84
1998 Ara J, Przedborski S, Naini AB, Jackson-Lewis V, Trifiletti RR, Horwitz J, Ischiropoulos H. Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Proceedings of the National Academy of Sciences of the United States of America. 95: 7659-63. PMID 9636206 DOI: 10.1073/pnas.95.13.7659  0.84
1998 Przedborski S, Jackson-Lewis V. Mechanisms of MPTP toxicity Movement Disorders. 13: 35-38. PMID 9613716  0.84
1998 Jakowec MW, Jackson-Lewis V, Chen X, Langston JW, Przedborski S. The postnatal development of AMPA receptor subunits in the basal ganglia of the rat Developmental Neuroscience. 20: 19-33. PMID 9600387 DOI: 10.1159/000017295  0.84
1998 Levivier M, Przedborski S. Quinolinic acid-induced lesions of the rat striatum: Quantitative autoradiographic binding assessment Neurological Research. 20: 46-56. PMID 9471103  0.84
1998 Przedborski S, Schon EA. Loss of ROS - A radical response Nature Genetics. 18: 99-100. PMID 9462732 DOI: 10.1038/ng0298-99  0.84
1997 Takahashi N, Miner LL, Sora I, Ujike H, Revay RS, Kostic V, Jackson-Lewis V, Przedborski S, Uhl GR. VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity. Proceedings of the National Academy of Sciences of the United States of America. 94: 9938-43. PMID 9275230 DOI: 10.1073/pnas.94.18.9938  0.84
1997 Kostic V, Jackson-Lewis V, De Bilbao F, Dubois-Dauphin M, Przedborski S. Bcl-2: Prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis Science. 277: 559-562. PMID 9228005 DOI: 10.1126/science.277.5325.559  0.84
1997 Mena MA, Khan U, Togasaki DM, Sulzer D, Epstein CJ, Przedborski S. Effects of wild-type and mutated copper/zinc superoxide dismutase on neuronal survival and L-DOPA-induced toxicity in postnatal midbrain culture. Journal of Neurochemistry. 69: 21-33. PMID 9202290  0.84
1997 Kostic V, Gurney ME, Deng HX, Siddique T, Epstein CJ, Przedborski S. Midbrain dopaminergic neuronal degeneration in a transgenic mouse model of familial amyotrophic lateral sclerosis. Annals of Neurology. 41: 497-504. PMID 9124807 DOI: 10.1002/ana.410410413  0.84
1996 Przedborski S, Donaldson D, Jakowec M, Kish SJ, Guttman M, Rosoklija G, Hays AP. Brain superoxide dismutase, catalase, and glutathione peroxidase activities in amyotrophic lateral sclerosis. Annals of Neurology. 39: 158-65. PMID 8967746 DOI: 10.1002/ana.410390204  0.84
1996 Przedborski S, Dhawan V, Donaldson DM, Murphy PL, McKenna-Yasek D, Mandel FS, Brown RH, Eidelberg D. Nigrostriatal dopaminergic function in familial amyotrophic lateral sclerosis patients with and without copper/zinc superoxide dismutase mutations. Neurology. 47: 1546-51. PMID 8960743  0.84
1996 Przedborski S, Kostic VN, Burke RE. Delayed-onset dyskinesias. Neurology. 47: 1358-9. PMID 8909476  0.84
1996 Mitchell JD, Fitzmaurice PS, Knight JM, Shaw IC, Przedborski S, Donaldson D. CNS distribution of free-radical inactivating enzymes in amyotrophic lateral sclerosis [2] Annals of Neurology. 40: 689-690. PMID 8871594  0.84
1996 Przedborski S, Khan U, Kostic V, Carlson E, Epstein CJ, Sulzer D. Increased superoxide dismutase activity improves survival of cultured postnatal midbrain neurons. Journal of Neurochemistry. 67: 1383-92. PMID 8858919  0.84
1996 Raftopoulos C, Dethy S, Laute MA, Goldman S, Naini AB, Przedborski S, Hildebrand J. Slow increase of homovanillic acid in cerebrospinal fluid after levodopa administration Movement Disorders. 11: 59-62. PMID 8771068 DOI: 10.1002/mds.870110111  0.84
1996 Dethy S, Laute MA, Togasaki DM, Przedborski S, Damhaut P, Thiry P, Hildebrand J, Goldman S. Systemic and intrastriatal theophylline have opposite effects on dopamine and dopamine metabolites measured by intrastriatal microdialysis in the rat Neuroscience Letters. 208: 159-162. PMID 8733294 DOI: 10.1016/0304-3940(96)12571-4  0.84
1996 Przedborski S, Donaldson DM, Murphy PL, Hirsch O, Lange D, Naini AB, McKenna-Yasek D, Brown RH. Blood superoxide dismutase, catalase and glutathione peroxidase activities in familial and sporadic amyotrophic lateral sclerosis. Neurodegeneration : a Journal For Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration. 5: 57-64. PMID 8731383 DOI: 10.1006/neur.1996.0008  0.84
1996 Przedborski S, Jackson-Lewis V, Yokoyama R, Shibata T, Dawson VL, Dawson TM. Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 93: 4565-71. PMID 8643444  0.84
1995 Levivier M, Gash DM, Przedborski S. Time course of the neuroprotective effect of transplantation on quinolinic acid-induced lesions of the striatum Neuroscience. 69: 43-50. PMID 8637631 DOI: 10.1016/0306-4522(95)00230-G  0.84
1995 Levivier M, Przedborski S, Bencsics C, Kang UJ. Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease Journal of Neuroscience. 15: 7810-7820. PMID 8613721  0.84
1995 Eidelberg D, Moeller JR, Ishikawa T, Dhawan V, Spetsieris P, Przedborski S, Fahn S. The metabolic topography of idiopathic torsion dystonia. Brain : a Journal of Neurology. 118: 1473-84. PMID 8595478  0.84
1995 Jackson-Lewis V, Jakowec M, Burke RE, Przedborski S. Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neurodegeneration : a Journal For Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration. 4: 257-69. PMID 8581558 DOI: 10.1016/1055-8330(95)90015-2  0.84
1995 Petzinger G, Mayer SA, Przedborski S. Fentanyl-induced dyskinesias. Movement Disorders : Official Journal of the Movement Disorder Society. 10: 679-80. PMID 8552126 DOI: 10.1002/mds.870100526  0.84
1995 Przedborski S, Levivier M, Raftopoulos C, Naini AB, Hildebrand J. Peripheral and central pharmacokinetics of apomorphine and its effect on dopamine metabolism in humans Movement Disorders. 10: 28-36. PMID 7885353 DOI: 10.1002/mds.870100107  0.84
1995 Przedborski S, Jackson-Lewis V, Fahn S. Antiparkinsonian therapies and brain mitochondrial complex I activity. Movement Disorders : Official Journal of the Movement Disorder Society. 10: 312-7. PMID 7651449 DOI: 10.1002/mds.870100314  0.84
1995 Parsons B, Togasaki DM, Kassir S, Przedborski S. Neuroleptics up-regulate adenosine A2a receptors in rat striatum: Implications for the mechanism and the treatment of tardive dyskinesia Journal of Neurochemistry. 65: 2057-2064. PMID 7595490  0.84
1995 Eidelberg D, Moeller JR, Ishikawa T, Dhawan V, Spetsieris P, Chaly T, Belakhlef A, Mandel F, Przedborski S, Fahn S. Early differential diagnosis of Parkinson's disease with 18F-fluorodeoxyglucose and positron emission tomography. Neurology. 45: 1995-2004. PMID 7501148  0.84
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