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Michael Hutton, PhD - Publications

Neuroscience Mayo Clinic Jacksonville, Jacksonville, FL, United States 

221 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Corriveau RA, Koroshetz WJ, Gladman JT, Jeon S, Babcock D, Bennett DA, Carmichael ST, Dickinson SL, Dickson DW, Emr M, Fillit H, Greenberg SM, Hutton ML, Knopman DS, Manly JJ, et al. Alzheimer's Disease-Related Dementias Summit 2016: National research priorities. Neurology. PMID 29117955 DOI: 10.1212/Wnl.0000000000004717  0.68
2016 Hutton MJ, McGuire RA, Dunn R, Williams R, Robertson P, Twaddle B, Kiely P, Clarke A, Mazda K, Davies P, Pagarigan KT, Dettori JR. Catastrophic Cervical Spine Injuries in Contact Sports. Global Spine Journal. 6: 721-734. PMID 27781193 DOI: 10.1055/s-0036-1586744  0.4
2016 Mead E, Kestoras D, Gibson Y, Hamilton L, Goodson R, Jones S, Eversden S, Davies P, O'Neill M, Hutton M, Szekeres P, Wolak J. Halting of Caspase Activity Protects Tau from MC1-Conformational Change and Aggregation. Journal of Alzheimer's Disease : Jad. PMID 27589517 DOI: 10.3233/Jad-150960  0.4
2015 McCarthy A, Lonergan R, Olszewska DA, O'Dowd S, Cummins G, Magennis B, Fallon EM, Pender N, Huey ED, Cosentino S, O'Rourke K, Kelly BD, O'Connell M, Delon I, Farrell M, ... ... Hutton M, et al. Closing the tau loop: the missing tau mutation. Brain : a Journal of Neurology. PMID 26297556 DOI: 10.1093/Brain/Awv234  0.6
2014 Siemers E, Dean RA, DeMattos RB, Hutton ML, Blennow K, Shaw LM, Holtzman DM. Anti-Aβ antibody target engagement: commentary regarding Watt et al. Acta Neuropathol 127:803-810 (2014). Acta Neuropathologica. 128: 609-10. PMID 25120192 DOI: 10.1007/S00401-014-1332-9  0.8
2014 Montine TJ, Koroshetz WJ, Babcock D, Dickson DW, Galpern WR, Glymour MM, Greenberg SM, Hutton ML, Knopman DS, Kuzmichev AN, Manly JJ, Marder KS, Miller BL, Phelps CH, Seeley WW, et al. Recommendations of the Alzheimer's disease-related dementias conference. Neurology. 83: 851-60. PMID 25080517 DOI: 10.1212/Wnl.0000000000000733  0.8
2014 Rao MV, McBrayer MK, Campbell J, Kumar A, Hashim A, Sershen H, Stavrides PH, Ohno M, Hutton M, Nixon RA. Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 9222-34. PMID 25009256 DOI: 10.1523/Jneurosci.1132-14.2014  0.8
2014 Ahmed Z, Cooper J, Murray TK, Garn K, McNaughton E, Clarke H, Parhizkar S, Ward MA, Cavallini A, Jackson S, Bose S, Clavaguera F, Tolnay M, Lavenir I, Goedert M, ... Hutton ML, et al. A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity. Acta Neuropathologica. 127: 667-83. PMID 24531916 DOI: 10.1007/S00401-014-1254-6  0.8
2014 Baker M, Strongosky AJ, Sanchez-Contreras MY, Yang S, Ferguson W, Calne DB, Calne S, Stoessl AJ, Allanson JE, Broderick DF, Hutton ML, Dickson DW, Ross OA, Wszolek ZK, Rademakers R. SLC20A2 and THAP1 deletion in familial basal ganglia calcification with dystonia. Neurogenetics. 15: 23-30. PMID 24135862 DOI: 10.1007/S10048-013-0378-5  0.8
2013 Cavallini A, Brewerton S, Bell A, Sargent S, Glover S, Hardy C, Moore R, Calley J, Ramachandran D, Poidinger M, Karran E, Davies P, Hutton M, Szekeres P, Bose S. An unbiased approach to identifying tau kinases that phosphorylate tau at sites associated with Alzheimer disease. The Journal of Biological Chemistry. 288: 23331-47. PMID 23798682 DOI: 10.1074/jbc.M113.463984  0.8
2012 Demattos RB, Lu J, Tang Y, Racke MM, Delong CA, Tzaferis JA, Hole JT, Forster BM, McDonnell PC, Liu F, Kinley RD, Jordan WH, Hutton ML. A plaque-specific antibody clears existing β-amyloid plaques in Alzheimer's disease mice. Neuron. 76: 908-20. PMID 23217740 DOI: 10.1016/j.neuron.2012.10.029  0.8
2012 Naylor MD, Karlawish JH, Arnold SE, Khachaturian AS, Khachaturian ZS, Lee VM, Baumgart M, Banerjee S, Beck C, Blennow K, Brookmeyer R, Brunden KR, Buckwalter KC, Comer M, Covinsky K, ... ... Hutton M, et al. Advancing Alzheimer's disease diagnosis, treatment, and care: recommendations from the Ware Invitational Summit. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 8: 445-52. PMID 22959699 DOI: 10.1016/J.Jalz.2012.08.001  0.8
2011 Lee VM, Brunden KR, Hutton M, Trojanowski JQ. Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets. Cold Spring Harbor Perspectives in Medicine. 1: a006437. PMID 22229117 DOI: 10.1101/Cshperspect.A006437  0.8
2011 Chai X, Wu S, Murray TK, Kinley R, Cella CV, Sims H, Buckner N, Hanmer J, Davies P, O'Neill MJ, Hutton ML, Citron M. Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression. The Journal of Biological Chemistry. 286: 34457-67. PMID 21841002 DOI: 10.1074/jbc.M111.229633  0.8
2011 Pickford F, Marcus J, Camargo LM, Xiao Q, Graham D, Mo JR, Burkhardt M, Kulkarni V, Crispino J, Hering H, Hutton M. Progranulin is a chemoattractant for microglia and stimulates their endocytic activity. The American Journal of Pathology. 178: 284-95. PMID 21224065 DOI: 10.1016/J.Ajpath.2010.11.002  0.8
2011 Morgan D, Munireddy S, Alamed J, DeLeon J, Diamond DM, Bickford P, Hutton M, Lewis J, McGowan E, Gordon MN. Apparent behavioral benefits of tau overexpression in P301L tau transgenic mice Advances in Alzheimer's Disease. 1: 129-138. DOI: 10.3233/978-1-60750-733-8-129  0.8
2010 Webster J, Reiman EM, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Huentelman MJ, Craig DW, Coon KD, Beach T, Rohrer KC, Zhao AS, Leung D, Bryden L, Marlowe L, ... ... Hutton ML, et al. Whole genome association analysis shows that ACE is a risk factor for Alzheimer's disease and fails to replicate most candidates from Meta-analysis. International Journal of Molecular Epidemiology and Genetics. 1: 19-30. PMID 21537449  0.8
2010 Xu YF, Gendron TF, Zhang YJ, Lin WL, D'Alton S, Sheng H, Casey MC, Tong J, Knight J, Yu X, Rademakers R, Boylan K, Hutton M, McGowan E, Dickson DW, et al. Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 10851-9. PMID 20702714 DOI: 10.1523/Jneurosci.1630-10.2010  0.8
2010 Ahmed Z, Sheng H, Xu YF, Lin WL, Innes AE, Gass J, Yu X, Wuertzer CA, Hou H, Chiba S, Yamanouchi K, Leissring M, Petrucelli L, Nishihara M, Hutton ML, et al. Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging. The American Journal of Pathology. 177: 311-24. PMID 20522652 DOI: 10.2353/Ajpath.2010.090915  0.8
2010 Litvan I, Chism A, Litvan J, Cambon A, Hutton M. H1/H1 genotype influences symptom severity in corticobasal syndrome. Movement Disorders : Official Journal of the Movement Disorder Society. 25: 760-3. PMID 20437541 DOI: 10.1002/Mds.22804  0.8
2010 Kelley BJ, Haidar W, Boeve BF, Baker M, Shiung M, Knopman DS, Rademakers R, Hutton M, Adamson J, Kuntz KM, Dickson DW, Parisi JE, Smith GE, Petersen RC. Alzheimer disease-like phenotype associated with the c.154delA mutation in progranulin. Archives of Neurology. 67: 171-7. PMID 20142525 DOI: 10.1001/Archneurol.2010.113  0.8
2010 Azorsa DO, Robeson RH, Frost D, Meec hoovet B, Brautigam GR, Dickey C, Beaudry C, Basu GD, Holz DR, Hernandez JA, Bisanz KM, Gwinn L, Grover A, Rogers J, Reiman EM, ... Hutton M, et al. High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation. Bmc Genomics. 11: 25. PMID 20067632 DOI: 10.1186/1471-2164-11-25  0.8
2010 Townsend M, Qu Y, Gray A, Wu Z, Seto T, Hutton M, Shearman MS, Middleton RE. Oral treatment with a gamma-secretase inhibitor improves long-term potentiation in a mouse model of Alzheimer's disease. The Journal of Pharmacology and Experimental Therapeutics. 333: 110-9. PMID 20056779 DOI: 10.1124/jpet.109.163691  0.8
2010 Corneveaux JJ, Liang WS, Reiman EM, Webster JA, Myers AJ, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Craig DW, Coon KD, Dunckley T, Bandy D, Lee W, Chen K, ... ... Hutton ML, et al. Evidence for an association between KIBRA and late-onset Alzheimer's disease. Neurobiology of Aging. 31: 901-9. PMID 18789830 DOI: 10.1016/J.Neurobiolaging.2008.07.014  0.8
2010 Ahmed Z, Sheng H, Xu YF, Lin WL, Innes AE, Gass J, Yu X, Wuertzer CA, Hou H, Chiba S, Yamanouchi K, Leissring M, Petrucelli L, Nishihara M, Hutton ML, et al. Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging (American Journal of Pathology (2010), 177, (311-324)) American Journal of Pathology. 177: 2146. DOI: 10.2353/Ajpath.2010.100772  0.8
2009 O'Farrell CA, Martin KL, Hutton M, Delatycki MB, Cookson MR, Lockhart PJ. Mutant torsinA interacts with tyrosine hydroxylase in cultured cells. Neuroscience. 164: 1127-37. PMID 19761814 DOI: 10.1016/J.Neuroscience.2009.09.017  0.8
2009 Adams SJ, Crook RJ, Deture M, Randle SJ, Innes AE, Yu XZ, Lin WL, Dugger BN, McBride M, Hutton M, Dickson DW, McGowan E. Overexpression of wild-type murine tau results in progressive tauopathy and neurodegeneration. The American Journal of Pathology. 175: 1598-609. PMID 19717642 DOI: 10.2353/Ajpath.2009.090462  0.8
2009 Pereson S, Wils H, Kleinberger G, McGowan E, Vandewoestyne M, Van Broeck B, Joris G, Cuijt I, Deforce D, Hutton M, Van Broeckhoven C, Kumar-Singh S. Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models. The Journal of Pathology. 219: 173-81. PMID 19557827 DOI: 10.1002/Path.2580  0.8
2009 Tatom JB, Wang DB, Dayton RD, Skalli O, Hutton ML, Dickson DW, Klein RL. Mimicking aspects of frontotemporal lobar degeneration and Lou Gehrig's disease in rats via TDP-43 overexpression. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 607-13. PMID 19223871 DOI: 10.1038/Mt.2009.3  0.8
2009 Kelley BJ, Haidar W, Boeve BF, Baker M, Graff-Radford NR, Krefft T, Frank AR, Jack CR, Shiung M, Knopman DS, Josephs KA, Parashos SA, Rademakers R, Hutton M, Pickering-Brown S, et al. Prominent phenotypic variability associated with mutations in Progranulin. Neurobiology of Aging. 30: 739-51. PMID 17949857 DOI: 10.1016/J.Neurobiolaging.2007.08.022  0.8
2008 Morgan D, Munireddy S, Alamed J, DeLeon J, Diamond DM, Bickford P, Hutton M, Lewis J, McGowan E, Gordon MN. Apparent behavioral benefits of tau overexpression in P301L tau transgenic mice. Journal of Alzheimer's Disease : Jad. 15: 605-14. PMID 19096159 DOI: 10.3233/Jad-2008-15407  0.8
2008 Rutherford NJ, Zhang YJ, Baker M, Gass JM, Finch NA, Xu YF, Stewart H, Kelley BJ, Kuntz K, Crook RJ, Sreedharan J, Vance C, Sorenson E, Lippa C, Bigio EH, ... ... Hutton M, et al. Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis. Plos Genetics. 4: e1000193. PMID 18802454 DOI: 10.1371/Journal.Pgen.1000193  0.8
2008 Rademakers R, Eriksen JL, Baker M, Robinson T, Ahmed Z, Lincoln SJ, Finch N, Rutherford NJ, Crook RJ, Josephs KA, Boeve BF, Knopman DS, Petersen RC, Parisi JE, Caselli RJ, ... ... Hutton ML, et al. Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia. Human Molecular Genetics. 17: 3631-42. PMID 18723524 DOI: 10.1093/Hmg/Ddn257  0.8
2008 Pickering-Brown S, Hutton M. The genetics of frontotemporal dementia. Handbook of Clinical Neurology. 89: 383-92. PMID 18631762 DOI: 10.1016/S0072-9752(07)01236-5  0.8
2008 Rudzinski LA, Fletcher RM, Dickson DW, Crook R, Hutton ML, Adamson J, Graff-Radford NR. Early onset familial Alzheimer Disease with spastic paraparesis, dysarthria, and seizures and N135S mutation in PSEN1. Alzheimer Disease and Associated Disorders. 22: 299-307. PMID 18580586 DOI: 10.1097/Wad.0B013E3181732399  0.8
2008 Coppola G, Karydas A, Rademakers R, Wang Q, Baker M, Hutton M, Miller BL, Geschwind DH. Gene expression study on peripheral blood identifies progranulin mutations. Annals of Neurology. 64: 92-6. PMID 18551524 DOI: 10.1002/Ana.21397  0.8
2008 Sando SB, Melquist S, Cannon A, Hutton M, Sletvold O, Saltvedt I, White LR, Lydersen S, Aasly J. Risk-reducing effect of education in Alzheimer's disease. International Journal of Geriatric Psychiatry. 23: 1156-62. PMID 18484674 DOI: 10.1002/Gps.2043  0.8
2008 Wider C, Uitti RJ, Wszolek ZK, Fang JY, Josephs KA, Baker MC, Rademakers R, Hutton ML, Dickson DW. Progranulin gene mutation with an unusual clinical and neuropathologic presentation. Movement Disorders : Official Journal of the Movement Disorder Society. 23: 1168-73. PMID 18442119 DOI: 10.1002/Mds.22065  0.8
2008 Sando SB, Melquist S, Cannon A, Hutton ML, Sletvold O, Saltvedt I, White LR, Lydersen S, Aasly JO. APOE epsilon 4 lowers age at onset and is a high risk factor for Alzheimer's disease; a case control study from central Norway. Bmc Neurology. 8: 9. PMID 18416843 DOI: 10.1186/1471-2377-8-9  0.8
2008 Boeve BF, Hutton M. Refining frontotemporal dementia with parkinsonism linked to chromosome 17: introducing FTDP-17 (MAPT) and FTDP-17 (PGRN). Archives of Neurology. 65: 460-4. PMID 18413467 DOI: 10.1001/Archneur.65.4.460  0.8
2008 Vega IE, Traverso EE, Ferrer-Acosta Y, Matos E, Colon M, Gonzalez J, Dickson D, Hutton M, Lewis J, Yen SH. A novel calcium-binding protein is associated with tau proteins in tauopathy. Journal of Neurochemistry. 106: 96-106. PMID 18346207 DOI: 10.1111/J.1471-4159.2008.05339.X  0.8
2008 Ertekin-Taner N, Younkin LH, Yager DM, Parfitt F, Baker MC, Asthana S, Hutton ML, Younkin SG, Graff-Radford NR. Plasma amyloid beta protein is elevated in late-onset Alzheimer disease families. Neurology. 70: 596-606. PMID 17914065 DOI: 10.1212/01.WNL.0000278386.00035.21  0.8
2008 Wider C, Melquist S, Hauf M, Solida A, Cobb SA, Kachergus JM, Gass J, Coon KD, Baker M, Cannon A, Stephan DA, Schorderet DF, Ghika J, Burkhard PR, Kapatos G, ... Hutton M, et al. Study of a Swiss dopa-responsive dystonia family with a deletion in GCH1: redefining DYT14 as DYT5. Neurology. 70: 1377-83. PMID 17804835 DOI: 10.1212/01.Wnl.0000275527.35752.C5  0.8
2007 Goldman JS, Adamson J, Karydas A, Miller BL, Hutton M. New genes, new dilemmas: FTLD genetics and its implications for families. American Journal of Alzheimer's Disease and Other Dementias. 22: 507-15. PMID 18166610 DOI: 10.1177/1533317507306662  0.8
2007 Bolmont T, Clavaguera F, Meyer-Luehmann M, Herzig MC, Radde R, Staufenbiel M, Lewis J, Hutton M, Tolnay M, Jucker M. Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice. The American Journal of Pathology. 171: 2012-20. PMID 18055549 DOI: 10.2353/Ajpath.2007.070403  0.8
2007 Hu WT, Mandrekar JN, Parisi JE, Knopman DS, Boeve BF, Petersen RC, Hutton M, Dickson DW, Josephs KA. Clinical features of pathologic subtypes of behavioral--variant frontotemporal dementia. Archives of Neurology. 64: 1611-6. PMID 17998443 DOI: 10.1001/Archneur.64.11.1611  0.8
2007 Seabrook GR, Ray WJ, Shearman M, Hutton M. Beyond amyloid: the next generation of Alzheimer's disease therapeutics. Molecular Interventions. 7: 261-70. PMID 17932415 DOI: 10.1124/mi.7.5.8  0.8
2007 Caselli RJ, Reiman EM, Locke DE, Hutton ML, Hentz JG, Hoffman-Snyder C, Woodruff BK, Alexander GE, Osborne D. Cognitive domain decline in healthy apolipoprotein E epsilon4 homozygotes before the diagnosis of mild cognitive impairment. Archives of Neurology. 64: 1306-11. PMID 17846270 DOI: 10.1001/Archneur.64.9.1306  0.8
2007 Rademakers R, Baker M, Gass J, Adamson J, Huey ED, Momeni P, Spina S, Coppola G, Karydas AM, Stewart H, Johnson N, Hsiung GY, Kelley B, Kuntz K, Steinbart E, ... ... Hutton M, et al. Phenotypic variability associated with progranulin haploinsufficiency in patients with the common 1477C-->T (Arg493X) mutation: an international initiative. The Lancet. Neurology. 6: 857-68. PMID 17826340 DOI: 10.1016/S1474-4422(07)70221-1  0.8
2007 Rademakers R, Hutton M. The genetics of frontotemporal lobar degeneration. Current Neurology and Neuroscience Reports. 7: 434-42. PMID 17764635 DOI: 10.1007/S11910-007-0067-6  0.8
2007 Dunckley T, Huentelman MJ, Craig DW, Pearson JV, Szelinger S, Joshipura K, Halperin RF, Stamper C, Jensen KR, Letizia D, Hesterlee SE, Pestronk A, Levine T, Bertorini T, Graves MC, ... ... Hutton M, et al. Whole-genome analysis of sporadic amyotrophic lateral sclerosis. The New England Journal of Medicine. 357: 775-88. PMID 17671248 DOI: 10.1056/Nejmoa070174  0.8
2007 Haugarvoll K, Wszolek ZK, Hutton M. The genetics of frontotemporal dementia. Neurologic Clinics. 25: 697-715, vi. PMID 17659186 DOI: 10.1016/J.Ncl.2007.03.002  0.8
2007 Reiman EM, Webster JA, Myers AJ, Hardy J, Dunckley T, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Huentelman MJ, Craig DW, Coon KD, Liang WS, Herbert RH, Beach T, ... ... Hutton ML, et al. GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers. Neuron. 54: 713-20. PMID 17553421 DOI: 10.1016/J.Neuron.2007.05.022  0.8
2007 Davion S, Johnson N, Weintraub S, Mesulam MM, Engberg A, Mishra M, Baker M, Adamson J, Hutton M, Rademakers R, Bigio EH. Clinicopathologic correlation in PGRN mutations. Neurology. 69: 1113-21. PMID 17522386 DOI: 10.1212/01.Wnl.0000267701.58488.69  0.8
2007 Dickson DW, Rademakers R, Hutton ML. Progressive supranuclear palsy: pathology and genetics. Brain Pathology (Zurich, Switzerland). 17: 74-82. PMID 17493041 DOI: 10.1111/J.1750-3639.2007.00054.X  0.8
2007 Amador-Ortiz C, Lin WL, Ahmed Z, Personett D, Davies P, Duara R, Graff-Radford NR, Hutton ML, Dickson DW. TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease. Annals of Neurology. 61: 435-45. PMID 17469117 DOI: 10.1002/Ana.21154  0.8
2007 Berger Z, Roder H, Hanna A, Carlson A, Rangachari V, Yue M, Wszolek Z, Ashe K, Knight J, Dickson D, Andorfer C, Rosenberry TL, Lewis J, Hutton M, Janus C. Accumulation of pathological tau species and memory loss in a conditional model of tauopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 3650-62. PMID 17409229 DOI: 10.1523/Jneurosci.0587-07.2007  0.8
2007 Roder HM, Hutton ML. Microtubule-associated protein tau as a therapeutic target in neurodegenerative disease. Expert Opinion On Therapeutic Targets. 11: 435-42. PMID 17373874 DOI: 10.1517/14728222.11.4.435  0.8
2007 Schymick JC, Yang Y, Andersen PM, Vonsattel JP, Greenway M, Momeni P, Elder J, Chiò A, Restagno G, Robberecht W, Dahlberg C, Mukherjee O, Goate A, Graff-Radford N, Caselli RJ, ... Hutton M, et al. Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes. Journal of Neurology, Neurosurgery, and Psychiatry. 78: 754-6. PMID 17371905 DOI: 10.1136/Jnnp.2006.109553  0.8
2007 Melquist S, Craig DW, Huentelman MJ, Crook R, Pearson JV, Baker M, Zismann VL, Gass J, Adamson J, Szelinger S, Corneveaux J, Cannon A, Coon KD, Lincoln S, Adler C, ... ... Hutton M, et al. Identification of a novel risk locus for progressive supranuclear palsy by a pooled genomewide scan of 500,288 single-nucleotide polymorphisms. American Journal of Human Genetics. 80: 769-78. PMID 17357082 DOI: 10.1086/513320  0.8
2007 Whitwell JL, Jack CR, Baker M, Rademakers R, Adamson J, Boeve BF, Knopman DS, Parisi JF, Petersen RC, Dickson DW, Hutton ML, Josephs KA. Voxel-based morphometry in frontotemporal lobar degeneration with ubiquitin-positive inclusions with and without progranulin mutations. Archives of Neurology. 64: 371-6. PMID 17353379 DOI: 10.1001/Archneur.64.3.371  0.8
2007 Baba Y, Baker MC, Le Ber I, Brice A, Maeck L, Kohlhase J, Yasuda M, Stoppe G, Bugiani O, Sperfeld AD, Tsuboi Y, Uitti RJ, Farrer MJ, Ghetti B, Hutton ML, et al. Clinical and genetic features of families with frontotemporal dementia and parkinsonism linked to chromosome 17 with a P301S tau mutation. Journal of Neural Transmission (Vienna, Austria : 1996). 114: 947-50. PMID 17318302 DOI: 10.1007/S00702-007-0632-9  0.8
2007 Dickey CA, Kamal A, Lundgren K, Klosak N, Bailey RM, Dunmore J, Ash P, Shoraka S, Zlatkovic J, Eckman CB, Patterson C, Dickson DW, Nahman NS, Hutton M, Burrows F, et al. The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. The Journal of Clinical Investigation. 117: 648-58. PMID 17304350 DOI: 10.1172/Jci29715  0.8
2007 Ahmed Z, Mackenzie IR, Hutton ML, Dickson DW. Progranulin in frontotemporal lobar degeneration and neuroinflammation. Journal of Neuroinflammation. 4: 7. PMID 17291356 DOI: 10.1186/1742-2094-4-7  0.8
2007 Josephs KA, Ahmed Z, Katsuse O, Parisi JF, Boeve BF, Knopman DS, Petersen RC, Davies P, Duara R, Graff-Radford NR, Uitti RJ, Rademakers R, Adamson J, Baker M, Hutton ML, et al. Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations. Journal of Neuropathology and Experimental Neurology. 66: 142-51. PMID 17278999 DOI: 10.1097/Nen.0B013E31803020Cf  0.8
2007 Mehta SG, Watts GD, Adamson JL, Hutton M, Umberger G, Xiong S, Ramdeen S, Lovell MA, Kimonis VE, Smith CD. APOE is a potential modifier gene in an autosomal dominant form of frontotemporal dementia (IBMPFD). Genetics in Medicine : Official Journal of the American College of Medical Genetics. 9: 9-13. PMID 17224685 DOI: 10.1097/Gim.0B013E31802D830D  0.8
2007 Mesulam M, Johnson N, Krefft TA, Gass JM, Cannon AD, Adamson JL, Bigio EH, Weintraub S, Dickson DW, Hutton ML, Graff-Radford NR. Progranulin mutations in primary progressive aphasia: the PPA1 and PPA3 families. Archives of Neurology. 64: 43-7. PMID 17210807 DOI: 10.1001/Archneur.64.1.43  0.8
2007 Arvanitakis Z, Witte RJ, Dickson DW, Tsuboi Y, Uitti RJ, Slowinski J, Hutton ML, Lin SC, Boeve BF, Cheshire WP, Pooley RA, Liss JM, Caviness JN, Strongosky AJ, Wszolek ZK. Clinical-pathologic study of biomarkers in FTDP-17 (PPND family with N279K tau mutation). Parkinsonism & Related Disorders. 13: 230-9. PMID 17196872 DOI: 10.1016/J.Parkreldis.2006.10.007  0.8
2007 Pearson JV, Huentelman MJ, Halperin RF, Tembe WD, Melquist S, Homer N, Brun M, Szelinger S, Coon KD, Zismann VL, Webster JA, Beach T, Sando SB, Aasly JO, Heun R, ... ... Hutton ML, et al. Identification of the genetic basis for complex disorders by use of pooling-based genomewide single-nucleotide-polymorphism association studies. American Journal of Human Genetics. 80: 126-39. PMID 17160900 DOI: 10.1086/510686  0.8
2007 Dächsel JC, Ross OA, Mata IF, Kachergus J, Toft M, Cannon A, Baker M, Adamson J, Hutton M, Dickson DW, Farrer MJ. Lrrk2 G2019S substitution in frontotemporal lobar degeneration with ubiquitin-immunoreactive neuronal inclusions. Acta Neuropathologica. 113: 601-6. PMID 17151837 DOI: 10.1007/S00401-006-0178-1  0.8
2007 Duff K, Krishnamurthy P, Planel E, Hutton M. Animal models of tauopathy Alzheimer's Disease: Advances in Genetics, Molecular and Cellular Biology. 215-236. DOI: 10.1007/978-0-387-35135-3_13  0.8
2006 Golde TE, Dickson D, Hutton M. Filling the gaps in the abeta cascade hypothesis of Alzheimer's disease. Current Alzheimer Research. 3: 421-30. PMID 17168641 DOI: 10.2174/156720506779025189  0.8
2006 Momeni P, Schymick J, Jain S, Cookson MR, Cairns NJ, Greggio E, Greenway MJ, Berger S, Pickering-Brown S, Chiò A, Fung HC, Holtzman DM, Huey ED, Wassermann EM, Adamson J, ... Hutton ML, et al. Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD. Bmc Neurology. 6: 44. PMID 17166276 DOI: 10.1186/1471-2377-6-44  0.8
2006 Momeni P, Bell J, Duckworth J, Hutton M, Mann D, Brown SP, Hardy J. Sequence analysis of all identified open reading frames on the frontal temporal dementia haplotype on chromosome 3 fails to identify unique coding variants except in CHMP2B. Neuroscience Letters. 410: 77-9. PMID 17095158 DOI: 10.1016/J.Neulet.2006.06.065  0.8
2006 Pickering-Brown SM, Baker M, Gass J, Boeve BF, Loy CT, Brooks WS, Mackenzie IR, Martins RN, Kwok JB, Halliday GM, Kril J, Schofield PR, Mann DM, Hutton M. Mutations in progranulin explain atypical phenotypes with variants in MAPT. Brain : a Journal of Neurology. 129: 3124-6. PMID 17071927 DOI: 10.1093/Brain/Awl289  0.8
2006 Mackenzie IR, Baker M, Pickering-Brown S, Hsiung GY, Lindholm C, Dwosh E, Gass J, Cannon A, Rademakers R, Hutton M, Feldman HH. The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene. Brain : a Journal of Neurology. 129: 3081-90. PMID 17071926 DOI: 10.1093/Brain/Awl271  0.8
2006 Boeve BF, Baker M, Dickson DW, Parisi JE, Giannini C, Josephs KA, Hutton M, Pickering-Brown SM, Rademakers R, Tang-Wai D, Jack CR, Kantarci K, Shiung MM, Golde T, Smith GE, et al. Frontotemporal dementia and parkinsonism associated with the IVS1+1G->A mutation in progranulin: a clinicopathologic study. Brain : a Journal of Neurology. 129: 3103-14. PMID 17030535 DOI: 10.1093/Brain/Awl268  0.8
2006 Katsuse O, Lin WL, Lewis J, Hutton ML, Dickson DW. Neurofibrillary tangle-related synaptic alterations of spinal motor neurons of P301L tau transgenic mice. Neuroscience Letters. 409: 95-9. PMID 17010516 DOI: 10.1016/J.Neulet.2006.09.021  0.8
2006 Huey ED, Grafman J, Wassermann EM, Pietrini P, Tierney MC, Ghetti B, Spina S, Baker M, Hutton M, Elder JW, Berger SL, Heflin KA, Hardy J, Momeni P. Characteristics of frontotemporal dementia patients with a Progranulin mutation. Annals of Neurology. 60: 374-80. PMID 16983677 DOI: 10.1002/Ana.20969  0.8
2006 Gass J, Cannon A, Mackenzie IR, Boeve B, Baker M, Adamson J, Crook R, Melquist S, Kuntz K, Petersen R, Josephs K, Pickering-Brown SM, Graff-Radford N, Uitti R, Dickson D, ... ... Hutton M, et al. Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration. Human Molecular Genetics. 15: 2988-3001. PMID 16950801 DOI: 10.1093/Hmg/Ddl241  0.8
2006 Dickey CA, Ash P, Klosak N, Lee WC, Petrucelli L, Hutton M, Eckman CB. Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression. Molecular Neurodegeneration. 1: 6. PMID 16930453 DOI: 10.1186/1750-1326-1-6  0.8
2006 Wszolek ZK, Baba Y, Mackenzie IR, Uitti RJ, Strongosky AJ, Broderick DF, Baker MC, Melquist S, Hutton ML, Tsuboi Y, Allanson JE, Carr J, Kumar A, Calne SM, Miklossy J, et al. Autosomal dominant dystonia-plus with cerebral calcifications. Neurology. 67: 620-5. PMID 16924015 DOI: 10.1212/01.Wnl.0000230141.40784.09  0.8
2006 Baker M, Mackenzie IR, Pickering-Brown SM, Gass J, Rademakers R, Lindholm C, Snowden J, Adamson J, Sadovnick AD, Rollinson S, Cannon A, Dwosh E, Neary D, Melquist S, Richardson A, ... ... Hutton M, et al. Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature. 442: 916-9. PMID 16862116 DOI: 10.1038/Nature05016  0.8
2006 Dickey CA, Yue M, Lin WL, Dickson DW, Dunmore JH, Lee WC, Zehr C, West G, Cao S, Clark AM, Caldwell GA, Caldwell KA, Eckman C, Patterson C, Hutton M, et al. Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 6985-96. PMID 16807328 DOI: 10.1523/Jneurosci.0746-06.2006  0.8
2006 Le Corre S, Klafki HW, Plesnila N, Hübinger G, Obermeier A, Sahagún H, Monse B, Seneci P, Lewis J, Eriksen J, Zehr C, Yue M, McGowan E, Dickson DW, Hutton M, et al. An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 103: 9673-8. PMID 16769887 DOI: 10.1073/Pnas.0602913103  0.8
2006 Josephs KA, Katsuse O, Beccano-Kelly DA, Lin WL, Uitti RJ, Fujino Y, Boeve BF, Hutton ML, Baker MC, Dickson DW. Atypical progressive supranuclear palsy with corticospinal tract degeneration. Journal of Neuropathology and Experimental Neurology. 65: 396-405. PMID 16691120 DOI: 10.1097/01.Jnen.0000218446.38158.61  0.8
2006 McGowan E, Eriksen J, Hutton M. A decade of modeling Alzheimer's disease in transgenic mice. Trends in Genetics : Tig. 22: 281-9. PMID 16567017 DOI: 10.1016/J.Tig.2006.03.007  0.8
2006 Baba Y, Ghetti B, Baker MC, Uitti RJ, Hutton ML, Yamaguchi K, Bird T, Lin W, DeLucia MW, Dickson DW, Wszolek ZK. Hereditary diffuse leukoencephalopathy with spheroids: clinical, pathologic and genetic studies of a new kindred. Acta Neuropathologica. 111: 300-11. PMID 16523341 DOI: 10.1007/S00401-006-0046-Z  0.8
2006 Dickey CA, Dunmore J, Lu B, Wang JW, Lee WC, Kamal A, Burrows F, Eckman C, Hutton M, Petrucelli L. HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 753-5. PMID 16464956 DOI: 10.1096/Fj.05-5343Fje  0.8
2006 Cannon A, Baker M, Boeve B, Josephs K, Knopman D, Petersen R, Parisi J, Dickison D, Adamson J, Snowden J, Neary D, Mann D, Hutton M, Pickering-Brown SM. CHMP2B mutations are not a common cause of frontotemporal lobar degeneration. Neuroscience Letters. 398: 83-4. PMID 16431024 DOI: 10.1016/J.Neulet.2005.12.056  0.8
2006 Mackenzie IR, Baker M, West G, Woulfe J, Qadi N, Gass J, Cannon A, Adamson J, Feldman H, Lindholm C, Melquist S, Pettman R, Sadovnick AD, Dwosh E, Whiteheart SW, ... Hutton M, et al. A family with tau-negative frontotemporal dementia and neuronal intranuclear inclusions linked to chromosome 17. Brain : a Journal of Neurology. 129: 853-67. PMID 16401619 DOI: 10.1093/Brain/Awh724  0.88
2006 DeTure M, Granger B, Grover A, Hutton M, Yen SH. Evidence for independent mechanisms and a multiple-hit model of tau assembly. Biochemical and Biophysical Research Communications. 339: 858-64. PMID 16325769 DOI: 10.1016/J.Bbrc.2005.11.087  0.8
2005 Lin WL, Zehr C, Lewis J, Hutton M, Yen SH, Dickson DW. Progressive white matter pathology in the spinal cord of transgenic mice expressing mutant (P301L) human tau. Journal of Neurocytology. 34: 397-410. PMID 16902761 DOI: 10.1007/S11068-006-8726-0  0.8
2005 Ramsden M, Kotilinek L, Forster C, Paulson J, McGowan E, SantaCruz K, Guimaraes A, Yue M, Lewis J, Carlson G, Hutton M, Ashe KH. Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L). The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10637-47. PMID 16291936 DOI: 10.1523/Jneurosci.3279-05.2005  0.8
2005 Rodriguez-Martin T, Garcia-Blanco MA, Mansfield SG, Grover AC, Hutton M, Yu Q, Zhou J, Anderton BH, Gallo JM. Reprogramming of tau alternative splicing by spliceosome-mediated RNA trans-splicing: implications for tauopathies. Proceedings of the National Academy of Sciences of the United States of America. 102: 15659-64. PMID 16230627 DOI: 10.1073/Pnas.0503150102  0.8
2005 Rademakers R, Melquist S, Cruts M, Theuns J, Del-Favero J, Poorkaj P, Baker M, Sleegers K, Crook R, De Pooter T, Bel Kacem S, Adamson J, Van den Bossche D, Van den Broeck M, Gass J, ... ... Hutton ML, et al. High-density SNP haplotyping suggests altered regulation of tau gene expression in progressive supranuclear palsy. Human Molecular Genetics. 14: 3281-92. PMID 16195395 DOI: 10.1093/Hmg/Ddi361  0.8
2005 Hardy J, Pittman A, Myers A, Gwinn-Hardy K, Fung HC, de Silva R, Hutton M, Duckworth J. Evidence suggesting that Homo neanderthalensis contributed the H2 MAPT haplotype to Homo sapiens. Biochemical Society Transactions. 33: 582-5. PMID 16042549 DOI: 10.1042/Bst0330582  0.8
2005 McGowan E, Pickford F, Kim J, Onstead L, Eriksen J, Yu C, Skipper L, Murphy MP, Beard J, Das P, Jansen K, Delucia M, Lin WL, Dolios G, Wang R, ... ... Hutton M, et al. Abeta42 is essential for parenchymal and vascular amyloid deposition in mice. Neuron. 47: 191-9. PMID 16039562 DOI: 10.1016/J.Neuron.2005.06.030  0.8
2005 Santacruz K, Lewis J, Spires T, Paulson J, Kotilinek L, Ingelsson M, Guimaraes A, DeTure M, Ramsden M, McGowan E, Forster C, Yue M, Orne J, Janus C, Mariash A, ... ... Hutton M, et al. Tau suppression in a neurodegenerative mouse model improves memory function. Science (New York, N.Y.). 309: 476-81. PMID 16020737 DOI: 10.1126/Science.1113694  0.8
2005 Rippon GA, Boeve BF, Parisi JE, Dickson DW, Ivnik RI, Jack CR, Hutton M, Baker M, Josephs KA, Knopman DS, Petersen RC. Late-onset frontotemporal dementia associated with progressive supranuclear palsy/argyrophilic grain disease/Alzheimer's disease pathology. Neurocase. 11: 204-11. PMID 16006341 DOI: 10.1080/13554790590944753  0.8
2005 Dickey CA, Eriksen J, Kamal A, Burrows F, Kasibhatla S, Eckman CB, Hutton M, Petrucelli L. Development of a high throughput drug screening assay for the detection of changes in tau levels -- proof of concept with HSP90 inhibitors. Current Alzheimer Research. 2: 231-8. PMID 15974923 DOI: 10.2174/1567205053585927  0.8
2005 Vega IE, Cui L, Propst JA, Hutton ML, Lee G, Yen SH. Increase in tau tyrosine phosphorylation correlates with the formation of tau aggregates. Brain Research. Molecular Brain Research. 138: 135-44. PMID 15913839 DOI: 10.1016/j.molbrainres.2005.04.015  0.8
2005 Baba Y, Broderick DF, Uitti RJ, Hutton ML, Wszolek ZK. Heredofamilial brain calcinosis syndrome. Mayo Clinic Proceedings. 80: 641-51. PMID 15887432 DOI: 10.4065/80.5.641  0.36
2005 Baba Y, Tsuboi Y, Baker MC, Uitti RJ, Hutton ML, Dickson DW, Farrer M, Putzke JD, Woodruff BK, Ghetti B, Murrell JR, Boeve BF, Petersen RC, Verpillat P, Brice A, et al. The effect of tau genotype on clinical features in FTDP-17. Parkinsonism & Related Disorders. 11: 205-8. PMID 15878580 DOI: 10.1016/J.Parkreldis.2005.01.003  0.8
2005 Halverson RA, Lewis J, Frausto S, Hutton M, Muma NA. Tau protein is cross-linked by transglutaminase in P301L tau transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 1226-33. PMID 15689560 DOI: 10.1523/Jneurosci.3263-04.2005  0.8
2005 Ertekin-Taner N, Ronald J, Feuk L, Prince J, Tucker M, Younkin L, Hella M, Jain S, Hackett A, Scanlin L, Kelly J, Kihiko-Ehman M, Neltner M, Hersh L, Kindy M, ... ... Hutton M, et al. Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene. Human Molecular Genetics. 14: 447-60. PMID 15615772 DOI: 10.1093/Hmg/Ddi041  0.8
2004 Oliveira JR, Spiteri E, Sobrido MJ, Hopfer S, Klepper J, Voit T, Gilbert J, Wszolek ZK, Calne DB, Stoessl AJ, Hutton M, Manyam BV, Boller F, Baquero M, Geschwind DH. Genetic heterogeneity in familial idiopathic basal ganglia calcification (Fahr disease). Neurology. 63: 2165-7. PMID 15596772 DOI: 10.1212/01.Wnl.0000145601.88274.88  0.8
2004 Woodruff BK, Baba Y, Hutton ML, Wszolek ZK, Tsuboi Y, Kobayashi T, Ghetti B, Arima K, Yasuda M, Rascol O. Haplotype-phenotype correlations in kindreds with the N279K mutation in the tau gene. Archives of Neurology. 61: 1327; author reply 1. PMID 15313857 DOI: 10.1001/archneur.61.8.1327-a  0.36
2004 Skipper L, Wilkes K, Toft M, Baker M, Lincoln S, Hulihan M, Ross OA, Hutton M, Aasly J, Farrer M. Linkage disequilibrium and association of MAPT H1 in Parkinson disease. American Journal of Human Genetics. 75: 669-77. PMID 15297935 DOI: 10.1086/424492  0.88
2004 Hutton M, McGowan E. Clearing tau pathology with Abeta immunotherapy--reversible and irreversible stages revealed. Neuron. 43: 293-4. PMID 15294135 DOI: 10.1016/J.Neuron.2004.07.023  0.88
2004 Sahara N, Vega IE, Ishizawa T, Lewis J, McGowan E, Hutton M, Dickson D, Yen SH. Phosphorylated p38MAPK specific antibodies cross-react with sarkosyl-insoluble hyperphosphorylated tau proteins. Journal of Neurochemistry. 90: 829-38. PMID 15287888 DOI: 10.1111/J.1471-4159.2004.02558.X  0.8
2004 Arendash GW, Lewis J, Leighty RE, McGowan E, Cracchiolo JR, Hutton M, Garcia MF. Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain. Brain Research. 1012: 29-41. PMID 15158158 DOI: 10.1016/J.Brainres.2004.02.081  0.8
2004 Garcia MF, Gordon MN, Hutton M, Lewis J, McGowan E, Dickey CA, Morgan D, Arendash GW. The retinal degeneration (rd) gene seriously impairs spatial cognitive performance in normal and Alzheimer's transgenic mice. Neuroreport. 15: 73-7. PMID 15106834 DOI: 10.1097/00001756-200401190-00015  0.8
2004 Zehr C, Lewis J, McGowan E, Crook J, Lin WL, Godwin K, Knight J, Dickson DW, Hutton M. Apoptosis in oligodendrocytes is associated with axonal degeneration in P301L tau mice. Neurobiology of Disease. 15: 553-62. PMID 15056463 DOI: 10.1016/J.Nbd.2003.12.011  0.8
2004 Pickering-Brown SM, Baker M, Nonaka T, Ikeda K, Sharma S, Mackenzie J, Simpson SA, Moore JW, Snowden JS, de Silva R, Revesz T, Hasegawa M, Hutton M, Mann DM. Frontotemporal dementia with Pick-type histology associated with Q336R mutation in the tau gene. Brain : a Journal of Neurology. 127: 1415-26. PMID 15047590 DOI: 10.1093/Brain/Awh147  0.8
2004 Petrucelli L, Dickson D, Kehoe K, Taylor J, Snyder H, Grover A, De Lucia M, McGowan E, Lewis J, Prihar G, Kim J, Dillmann WH, Browne SE, Hall A, Voellmy R, ... ... Hutton M, et al. CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. Human Molecular Genetics. 13: 703-14. PMID 14962978 DOI: 10.1093/Hmg/Ddh083  0.8
2004 Pickering-Brown S, Baker M, Bird T, Trojanowski J, Lee V, Morris H, Rossor M, Janssen JC, Neary D, Craufurd D, Richardson A, Snowden J, Hardy J, Mann D, Hutton M. Evidence of a founder effect in families with frontotemporal dementia that harbor the tau +16 splice mutation. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 125: 79-82. PMID 14755449 DOI: 10.1002/Ajmg.B.20083  0.88
2004 Klein RL, Lin WL, Dickson DW, Lewis J, Hutton M, Duff K, Meyer EM, King MA. Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau. The American Journal of Pathology. 164: 347-53. PMID 14695347 DOI: 10.1016/S0002-9440(10)63124-0  0.8
2003 Lin WL, Lewis J, Yen SH, Hutton M, Dickson DW. Ultrastructural neuronal pathology in transgenic mice expressing mutant (P301L) human tau. Journal of Neurocytology. 32: 1091-105. PMID 15044841 DOI: 10.1023/B:Neur.0000021904.61387.95  0.8
2003 Grover A, England E, Baker M, Sahara N, Adamson J, Granger B, Houlden H, Passant U, Yen SH, DeTure M, Hutton M. A novel tau mutation in exon 9 (1260V) causes a four-repeat tauopathy. Experimental Neurology. 184: 131-40. PMID 14637086 DOI: 10.1016/S0014-4886(03)00393-5  0.88
2003 Ertekin-Taner N, Ronald J, Asahara H, Younkin L, Hella M, Jain S, Gnida E, Younkin S, Fadale D, Ohyagi Y, Singleton A, Scanlin L, de Andrade M, Petersen R, Graff-Radford N, ... Hutton M, et al. Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Human Molecular Genetics. 12: 3133-43. PMID 14559775 DOI: 10.1093/Hmg/Ddg343  0.8
2003 Beach TG, Sue L, Scott S, Layne K, Newell A, Walker D, Baker M, Sahara N, Yen SH, Hutton M, Caselli R, Adler C, Connor D, Sabbagh M. Hippocampal sclerosis dementia with tauopathy. Brain Pathology (Zurich, Switzerland). 13: 263-78. PMID 12946017 DOI: 10.1111/J.1750-3639.2003.Tb00027.X  0.88
2003 Ishizawa T, Sahara N, Ishiguro K, Kersh J, McGowan E, Lewis J, Hutton M, Dickson DW, Yen SH. Co-localization of glycogen synthase kinase-3 with neurofibrillary tangles and granulovacuolar degeneration in transgenic mice. The American Journal of Pathology. 163: 1057-67. PMID 12937146 DOI: 10.1016/S0002-9440(10)63465-7  0.8
2003 Hogg M, Grujic ZM, Baker M, Demirci S, Guillozet AL, Sweet AP, Herzog LL, Weintraub S, Mesulam MM, LaPointe NE, Gamblin TC, Berry RW, Binder LI, de Silva R, Lees A, ... ... Hutton M, et al. The L266V tau mutation is associated with frontotemporal dementia and Pick-like 3R and 4R tauopathy. Acta Neuropathologica. 106: 323-36. PMID 12883828 DOI: 10.1007/S00401-003-0734-X  0.8
2003 Rippon GA, Crook R, Baker M, Halvorsen E, Chin S, Hutton M, Houlden H, Hardy J, Lynch T. Presenilin 1 mutation in an african american family presenting with atypical Alzheimer dementia. Archives of Neurology. 60: 884-8. PMID 12810495 DOI: 10.1001/Archneur.60.6.884  0.8
2003 Willis F, Graff-Radford N, Pinto M, Lawson L, Adamson J, Epstein D, Parfitt F, Hutton M, O'Brien PC. Apolipoprotein epsilon4 allele frequency in young Africans of Ugandan descent versus African Americans. Journal of the National Medical Association. 95: 71-6. PMID 12656452  0.52
2003 Tsuboi Y, Uitti RJ, Baker M, Hutton ML, Wszolek ZK. Clinical features of frontotemporal dementia due to the intronic tau 10(+16) mutation. Neurology. 60: 525-6. PMID 12578950  0.88
2003 Lin WL, Lewis J, Yen SH, Hutton M, Dickson DW. Filamentous tau in oligodendrocytes and astrocytes of transgenic mice expressing the human tau isoform with the P301L mutation. The American Journal of Pathology. 162: 213-8. PMID 12507904 DOI: 10.1016/S0002-9440(10)63812-6  0.8
2003 Wszolek ZK, Tsuboi Y, Farrer M, Uitti RJ, Hutton ML. Hereditary tauopathies and parkinsonism. Advances in Neurology. 91: 153-63. PMID 12442674  0.68
2002 Tsuboi Y, Baker M, Hutton ML, Uitti RJ, Rascol O, Delisle MB, Soulages X, Murrell JR, Ghetti B, Yasuda M, Komure O, Kuno S, Arima K, Sunohara N, Kobayashi T, et al. Clinical and genetic studies of families with the tau N279K mutation (FTDP-17). Neurology. 59: 1791-3. PMID 12473774  0.88
2002 Walker RH, Friedman J, Wiener J, Hobler R, Gwinn-Hardy K, Adam A, DeWolfe J, Gibbs R, Baker M, Farrer M, Hutton M, Hardy J. A family with a tau P301L mutation presenting with parkinsonism. Parkinsonism & Related Disorders. 9: 121-3. PMID 12473404 DOI: 10.1016/S1353-8020(02)00003-2  0.8
2002 Sahara N, Lewis J, DeTure M, McGowan E, Dickson DW, Hutton M, Yen SH. Assembly of tau in transgenic animals expressing P301L tau: alteration of phosphorylation and solubility. Journal of Neurochemistry. 83: 1498-508. PMID 12472903 DOI: 10.1046/J.1471-4159.2002.01241.X  0.8
2002 Morris HR, Baker M, Yasojima K, Houlden H, Khan MN, Wood NW, Hardy J, Grossman M, Trojanowski J, Revesz T, Bigio EH, Bergeron C, Janssen JC, McGeer PL, Rossor MN, ... ... Hutton M, et al. Analysis of tau haplotypes in Pick's disease. Neurology. 59: 443-5. PMID 12177383 DOI: 10.1212/Wnl.59.3.443  0.8
2002 Utton MA, Connell J, Asuni AA, van Slegtenhorst M, Hutton M, de Silva R, Lees AJ, Miller CC, Anderton BH. The slow axonal transport of the microtubule-associated protein tau and the transport rates of different isoforms and mutants in cultured neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 6394-400. PMID 12151518 DOI: 10.1523/Jneurosci.22-15-06394.2002  0.8
2002 Togo T, Sahara N, Yen SH, Cookson N, Ishizawa T, Hutton M, de Silva R, Lees A, Dickson DW. Argyrophilic grain disease is a sporadic 4-repeat tauopathy. Journal of Neuropathology and Experimental Neurology. 61: 547-56. PMID 12071638 DOI: 10.1093/Jnen/61.6.547  0.68
2002 Tsuboi Y, Uitti RJ, Delisle MB, Ferreira JJ, Brefel-Courbon C, Rascol O, Ghetti B, Murrell JR, Hutton M, Baker M, Wszolek ZK. Clinical features and disease haplotypes of individuals with the N279K tau gene mutation: a comparison of the pallidopontonigral degeneration kindred and a French family. Archives of Neurology. 59: 943-50. PMID 12056930 DOI: 10.1001/Archneur.59.6.943  0.88
2002 Tang-Wai D, Lewis P, Boeve B, Hutton M, Golde T, Baker M, Hardy J, Michels V, Ivnik R, Jack C, Petersen R. Familial frontotemporal dementia associated with a novel presenilin-1 mutation. Dementia and Geriatric Cognitive Disorders. 14: 13-21. PMID 12053127 DOI: 10.1159/000058328  0.92
2002 Ponting CP, Hutton M, Nyborg A, Baker M, Jansen K, Golde TE. Identification of a novel family of presenilin homologues. Human Molecular Genetics. 11: 1037-44. PMID 11978763 DOI: 10.1093/Hmg/11.9.1037  0.8
2002 Short RA, Graff-Radford NR, Adamson J, Baker M, Hutton M. Differences in tau and apolipoprotein E polymorphism frequencies in sporadic frontotemporal lobar degeneration syndromes. Archives of Neurology. 59: 611-5. PMID 11939896 DOI: 10.1001/Archneur.59.4.611  0.88
2002 Pickering-Brown SM, Richardson AM, Snowden JS, McDonagh AM, Burns A, Braude W, Baker M, Liu WK, Yen SH, Hardy J, Hutton M, Davies Y, Allsop D, Craufurd D, Neary D, et al. Inherited frontotemporal dementia in nine British families associated with intronic mutations in the tau gene. Brain : a Journal of Neurology. 125: 732-51. PMID 11912108 DOI: 10.1093/Brain/Awf069  0.92
2002 Grover A, DeTure M, Yen SH, Hutton M. Effects on splicing and protein function of three mutations in codon N296 of tau in vitro. Neuroscience Letters. 323: 33-6. PMID 11911984 DOI: 10.1016/S0304-3940(02)00124-6  0.88
2002 Amtul Z, Lewis PA, Piper S, Crook R, Baker M, Findlay K, Singleton A, Hogg M, Younkin L, Younkin SG, Hardy J, Hutton M, Boeve BF, Tang-Wai D, Golde TE. A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch. Neurobiology of Disease. 9: 269-73. PMID 11895378 DOI: 10.1006/Nbdi.2001.0473  0.8
2002 Farrer M, Hardy J, Hutton M, Maraganore D, Tsuboi Y, Wszolek ZK. Identifying genetic factors in Parkinson disease. Jama. 287: 715-6. PMID 11851532  0.8
2002 Boeve BF, Maraganore DM, Parisi JE, Ivnik RJ, Westmoreland BF, Dickson DW, Hutton M, Hardy J, Caselli RJ, Petersen RC. Corticobasal degeneration and frontotemporal dementia presentations in a kindred with nonspecific histopathology. Dementia and Geriatric Cognitive Disorders. 13: 80-90. PMID 11844889 DOI: 10.1159/000048638  0.8
2001 Mack TG, Dayanandan R, Van Slegtenhorst M, Whone A, Hutton M, Lovestone S, Anderton BH. Tau proteins with frontotemporal dementia-17 mutations have both altered expression levels and phosphorylation profiles in differentiated neuroblastoma cells. Neuroscience. 108: 701-12. PMID 11738505 DOI: 10.1016/S0306-4522(01)00434-1  0.64
2001 Morris HR, Khan MN, Janssen JC, Brown JM, Perez-Tur J, Baker M, Ozansoy M, Hardy J, Hutton M, Wood NW, Lees AJ, Revesz T, Lantos P, Rossor MN. The genetic and pathological classification of familial frontotemporal dementia. Archives of Neurology. 58: 1813-6. PMID 11708988 DOI: 10.1001/Archneur.58.11.1813  0.8
2001 Maraganore DM, Hernandez DG, Singleton AB, Farrer MJ, McDonnell SK, Hutton ML, Hardy JA, Rocca WA. Case-Control study of the extended tau gene haplotype in Parkinson's disease. Annals of Neurology. 50: 658-61. PMID 11706972 DOI: 10.1002/ana.1228  0.8
2001 Russ C, Powell JF, Zhao J, Baker M, Hutton M, Crawford F, Mullan M, Roks G, Cruts M, Lovestone S. The microtubule associated protein Tau gene and Alzheimer's disease--an association study and meta-analysis. Neuroscience Letters. 314: 92-6. PMID 11698154 DOI: 10.1016/S0304-3940(01)02289-3  0.8
2001 Liu WK, Le TV, Adamson J, Baker M, Cookson N, Hardy J, Hutton M, Yen SH, Dickson DW. Relationship of the extended tau haplotype to tau biochemistry and neuropathology in progressive supranuclear palsy. Annals of Neurology. 50: 494-502. PMID 11601500 DOI: 10.1002/Ana.1159  0.92
2001 Hutton M, Lewis J, Dickson D, Yen SH, McGowan E. Analysis of tauopathies with transgenic mice. Trends in Molecular Medicine. 7: 467-70. PMID 11597522 DOI: 10.1016/S1471-4914(01)02123-2  0.8
2001 Lewis J, Dickson DW, Lin WL, Chisholm L, Corral A, Jones G, Yen SH, Sahara N, Skipper L, Yager D, Eckman C, Hardy J, Hutton M, McGowan E. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science (New York, N.Y.). 293: 1487-91. PMID 11520987 DOI: 10.1126/Science.1058189  0.8
2001 Wszolek ZK, Tsuboi Y, Uitti RJ, Reed L, Hutton ML, Dickson DW. Progressive supranuclear palsy as a disease phenotype caused by the S305S tau gene mutation. Brain : a Journal of Neurology. 124: 1666-70. PMID 11459757 DOI: 10.1093/Brain/124.8.1666  0.68
2001 Anderton BH, Betts J, Blackstock WP, Brion JP, Chapman S, Connell J, Dayanandan R, Gallo JM, Gibb G, Hanger DP, Hutton M, Kardalinou E, Leroy K, Lovestone S, Mack T, et al. Sites of phosphorylation in tau and factors affecting their regulation. Biochemical Society Symposium. 73-80. PMID 11447841 DOI: 10.1042/Bst028A015B  0.8
2001 Litvan I, Baker M, Hutton M. Tau genotype: no effect on onset, symptom severity, or survival in progressive supranuclear palsy. Neurology. 57: 138-40. PMID 11445645 DOI: 10.1212/Wnl.57.1.138  0.8
2001 Ertekin-Taner N, Graff-Radford N, Younkin LH, Eckman C, Adamson J, Schaid DJ, Blangero J, Hutton M, Younkin SG. Heritability of plasma amyloid beta in typical late-onset Alzheimer's disease pedigrees. Genetic Epidemiology. 21: 19-30. PMID 11443731 DOI: 10.1002/Gepi.1015  0.8
2001 Houlden H, Baker M, Morris HR, MacDonald N, Pickering-Brown S, Adamson J, Lees AJ, Rossor MN, Quinn NP, Kertesz A, Khan MN, Hardy J, Lantos PL, St George-Hyslop P, Munoz DG, ... ... Hutton M, et al. Corticobasal degeneration and progressive supranuclear palsy share a common tau haplotype. Neurology. 56: 1702-6. PMID 11425937 DOI: 10.1212/Wnl.56.12.1702  0.8
2001 Wittmann CW, Wszolek MF, Shulman JM, Salvaterra PM, Lewis J, Hutton M, Feany MB. Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. Science (New York, N.Y.). 293: 711-4. PMID 11408621 DOI: 10.1126/Science.1062382  0.8
2001 Bigio EH, Vono MB, Satumtira S, Adamson J, Sontag E, Hynan LS, White CL, Baker M, Hutton M. Cortical synapse loss in progressive supranuclear palsy. Journal of Neuropathology and Experimental Neurology. 60: 403-10. PMID 11379815 DOI: 10.1093/Jnen/60.5.403  0.8
2001 Bigio EH, Lipton AM, Yen SH, Hutton ML, Baker M, Nacharaju P, White CL, Davies P, Lin W, Dickson DW. Frontal lobe dementia with novel tauopathy: sporadic multiple system tauopathy with dementia. Journal of Neuropathology and Experimental Neurology. 60: 328-41. PMID 11305868 DOI: 10.1093/Jnen/60.4.328  0.88
2001 Reed LA, Wszolek ZK, Hutton M. Phenotypic correlations in FTDP-17. Neurobiology of Aging. 22: 89-107. PMID 11164280 DOI: 10.1016/S0197-4580(00)00202-5  0.36
2000 Ertekin-Taner N, Graff-Radford N, Younkin LH, Eckman C, Baker M, Adamson J, Ronald J, Blangero J, Hutton M, Younkin SG. Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Science (New York, N.Y.). 290: 2303-4. PMID 11125143 DOI: 10.1126/Science.290.5500.2303  0.8
2000 Pickering-Brown S, Baker M, Yen SH, Liu WK, Hasegawa M, Cairns N, Lantos PL, Rossor M, Iwatsubo T, Davies Y, Allsop D, Furlong R, Owen F, Hardy J, Mann D, ... Hutton M, et al. Pick's disease is associated with mutations in the tau gene. Annals of Neurology. 48: 859-67. PMID 11117542 DOI: 10.1002/1531-8249(200012)48:6<859::Aid-Ana6>3.0.Co;2-1  0.92
2000 Houlden H, Baker M, McGowan E, Lewis P, Hutton M, Crook R, Wood NW, Kumar-Singh S, Geddes J, Swash M, Scaravilli F, Holton JL, Lashley T, Tomita T, Hashimoto T, et al. Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS-1 mutations that lead to exceptionally high amyloid-beta concentrations. Annals of Neurology. 48: 806-8. PMID 11079548 DOI: 10.1002/1531-8249(200011)48:5<806::Aid-Ana18>3.0.Co;2-F  0.8
2000 van Slegtenhorst M, Lewis J, Hutton M. The molecular genetics of the tauopathies. Experimental Gerontology. 35: 461-71. PMID 10959034 DOI: 10.1016/S0531-5565(00)00114-5  0.8
2000 Lewis J, McGowan E, Rockwood J, Melrose H, Nacharaju P, Van Slegtenhorst M, Gwinn-Hardy K, Paul Murphy M, Baker M, Yu X, Duff K, Hardy J, Corral A, Lin WL, Yen SH, ... ... Hutton M, et al. Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nature Genetics. 25: 402-5. PMID 10932182 DOI: 10.1038/78078  0.8
2000 Litvan I, Dickson DW, Buttner-Ennever JA, Delacourte A, Hutton M, Dubois B, Golbe LI, Hallett M, Schellenberg GD, Standaert D, Brooks DJ, Price D. Research goals in progressive supranuclear palsy. First International Brainstorming Conference on PSP. Movement Disorders : Official Journal of the Movement Disorder Society. 15: 446-58. PMID 10830408 DOI: 10.1002/1531-8257(200005)15:3<446::AID-MDS1005>3.0.CO;2-C  0.8
2000 Wszolek ZK, Uitti RJ, Hutton M. A mutation in the microtubule-associated protein tau in pallido-nigro-luysian degeneration. Neurology. 54: 2028-30. PMID 10822460 DOI: 10.1212/Wnl.54.10.2028  0.36
2000 Baker M, Graff-Radford D, Wavrant DeVrièze F, Graff-Radford N, Petersen RC, Kokmen E, Boeve B, Myllykangas L, Polvikoski T, Sulkava R, Verkoniemmi A, Tienari P, Haltia M, Hardy J, Hutton M, et al. No association between TAU haplotype and Alzheimer's disease in population or clinic based series or in familial disease. Neuroscience Letters. 285: 147-9. PMID 10793248 DOI: 10.1016/S0304-3940(00)01057-0  0.8
2000 Duff K, Knight H, Refolo LM, Sanders S, Yu X, Picciano M, Malester B, Hutton M, Adamson J, Goedert M, Burki K, Davies P. Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes. Neurobiology of Disease. 7: 87-98. PMID 10783293 DOI: 10.1006/Nbdi.1999.0279  0.8
2000 Albers DS, Augood SJ, Park LC, Browne SE, Martin DM, Adamson J, Hutton M, Standaert DG, Vonsattel JP, Gibson GE, Beal MF. Frontal lobe dysfunction in progressive supranuclear palsy: evidence for oxidative stress and mitochondrial impairment. Journal of Neurochemistry. 74: 878-81. PMID 10646541 DOI: 10.1046/J.1471-4159.2000.740878.X  0.8
2000 DeTure M, Ko LW, Yen S, Nacharaju P, Easson C, Lewis J, van Slegtenhorst M, Hutton M, Yen SH. Missense tau mutations identified in FTDP-17 have a small effect on tau-microtubule interactions. Brain Research. 853: 5-14. PMID 10627302 DOI: 10.1016/S0006-8993(99)02124-1  0.8
1999 Yen S, Easson C, Nacharaju P, Hutton M, Yen SH. FTDP-17 tau mutations decrease the susceptibility of tau to calpain I digestion. Febs Letters. 461: 91-5. PMID 10561502 DOI: 10.1016/S0014-5793(99)01427-1  0.8
1999 Yen SH, Hutton M, DeTure M, Ko LW, Nacharaju P. Fibrillogenesis of tau: insights from tau missense mutations in FTDP-17. Brain Pathology (Zurich, Switzerland). 9: 695-705. PMID 10517508 DOI: 10.1111/J.1750-3639.1999.Tb00551.X  0.68
1999 Prihar G, Verkkoniem A, Perez-Tur J, Crook R, Lincoln S, Houlden H, Somer M, Paetau A, Kalimo H, Grover A, Myllykangas L, Hutton M, Hardy J, Haltia M. Alzheimer disease PS-1 exon 9 deletion defined. Nature Medicine. 5: 1090. PMID 10502791 DOI: 10.1038/13383  0.8
1999 Froelich S, Houlden H, Rizzu P, Chakraverty S, Baker M, Kwon J, Nowotny P, Isaacs A, Nowotny V, Wauters E, van Baren MJ, Oostra BA, Hardy J, Lannfelt L, Goate A, ... Hutton M, et al. Construction of a detailed physical and transcript map of the FTDP-17 candidate region on chromosome 17q21. Genomics. 60: 129-36. PMID 10486204 DOI: 10.1006/Geno.1999.5892  0.8
1999 Farrer M, Gwinn-Hardy K, Hutton M, Hardy J. The genetics of disorders with synuclein pathology and parkinsonism. Human Molecular Genetics. 8: 1901-5. PMID 10469843 DOI: 10.1093/Hmg/8.10.1901  0.92
1999 Houlden H, Baker M, Adamson J, Grover A, Waring S, Dickson D, Lynch T, Boeve B, Petersen RC, Pickering-Brown S, Owen F, Neary D, Craufurd D, Snowden J, Mann D, ... Hutton M, et al. Frequency of tau mutations in three series of non-Alzheimer's degenerative dementia. Annals of Neurology. 46: 243-8. PMID 10443890 DOI: 10.1002/1531-8249(199908)46:2<243::Aid-Ana14>3.0.Co;2-L  0.88
1999 Pérez-Tur J, Buée L, Morris HR, Waring SC, Onstead L, Wavrant-De Vrièze F, Crook R, Buée-Scherrer V, Hof PR, Petersen RC, McGeer PL, Delacourte A, Hutton M, Siddique T, Ahlskog JE, et al. Neurodegenerative diseases of Guam: analysis of TAU. Neurology. 53: 411-3. PMID 10430438 DOI: 10.1212/Wnl.53.2.411  0.8
1999 Prihar G, Gonzalez de Chavez F, Baker M, Crook R, McGowan E, Grover A, Hardy J, Hutton M. A novel candidate presenilin-1 interacting protein containing tetratricopeptide repeats. Neuroreport. 10: 1409-15. PMID 10380955 DOI: 10.1097/00001756-199905140-00005  0.92
1999 Grover A, Houlden H, Baker M, Adamson J, Lewis J, Prihar G, Pickering-Brown S, Duff K, Hutton M. 5' splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10. The Journal of Biological Chemistry. 274: 15134-43. PMID 10329720 DOI: 10.1074/Jbc.274.21.15134  0.8
1999 Nacharaju P, Lewis J, Easson C, Yen S, Hackett J, Hutton M, Yen SH. Accelerated filament formation from tau protein with specific FTDP-17 missense mutations. Febs Letters. 447: 195-9. PMID 10214944 DOI: 10.1097/00005072-199905000-00157  0.8
1999 Dayanandan R, Van Slegtenhorst M, Mack TG, Ko L, Yen SH, Leroy K, Brion JP, Anderton BH, Hutton M, Lovestone S. Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation. Febs Letters. 446: 228-32. PMID 10100846 DOI: 10.1016/S0014-5793(99)00222-7  0.68
1999 Jicha GA, Rockwood JM, Berenfeld B, Hutton M, Davies P. Altered conformation of recombinant frontotemporal dementia-17 mutant tau proteins. Neuroscience Letters. 260: 153-6. PMID 10076890 DOI: 10.1016/S0304-3940(98)00980-X  0.8
1999 Baker M, Litvan I, Houlden H, Adamson J, Dickson D, Perez-Tur J, Hardy J, Lynch T, Bigio E, Hutton M. Association of an extended haplotype in the tau gene with progressive supranuclear palsy. Human Molecular Genetics. 8: 711-5. PMID 10072441 DOI: 10.1093/Hmg/8.4.711  0.8
1999 Morris HR, Perez-Tur J, Janssen JC, Brown J, Lees AJ, Wood NW, Hardy J, Hutton M, Rossor MN. Mutation in the tau exon 10 splice site region in familial frontotemporal dementia. Annals of Neurology. 45: 270-1. PMID 9989634 DOI: 10.1002/1531-8249(199902)45:2<270::Aid-Ana22>3.0.Co;2-2  0.8
1999 Kehoe P, Wavrant-De Vrieze F, Crook R, Wu WS, Holmans P, Fenton I, Spurlock G, Norton N, Williams H, Williams N, Lovestone S, Perez-Tur J, Hutton M, Chartier-Harlin MC, Shears S, et al. A full genome scan for late onset Alzheimer's disease. Human Molecular Genetics. 8: 237-45. PMID 9931331 DOI: 10.1093/Hmg/8.2.237  0.8
1999 Liu JH, Wei S, Burnette PK, Gamero AM, Hutton M, Djeu JY. Functional association of TGF-beta receptor II with cyclin B. Oncogene. 18: 269-75. PMID 9926943 DOI: 10.1038/Sj.Onc.1202263  0.8
1998 Hutton M, Pérez-Tur J, Hardy J. Genetics of Alzheimer's disease. Essays in Biochemistry. 33: 117-31. PMID 10488446 DOI: 10.1042/Bse0330117  0.92
1998 Hardy J, Duff K, Hardy KG, Perez-Tur J, Hutton M. Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau. Nature Neuroscience. 1: 355-8. PMID 10196523 DOI: 10.1038/1565  0.8
1998 Litvan I, Hutton M. Clinical and genetic aspects of progressive supranuclear palsy. Journal of Geriatric Psychiatry and Neurology. 11: 107-14. PMID 9877531 DOI: 10.1177/089198879801100208  0.8
1998 Wu WS, Holmans P, Wavrant-DeVrièze F, Shears S, Kehoe P, Crook R, Booth J, Williams N, Pérez-Tur J, Roehl K, Fenton I, Chartier-Harlin MC, Lovestone S, Williams J, Hutton M, et al. Genetic studies on chromosome 12 in late-onset Alzheimer disease. Jama. 280: 619-22. PMID 9718053 DOI: 10.1001/Jama.280.7.619  0.92
1998 Isaacs A, Baker M, Wavrant-De Vrièze F, Hutton M. Determination of the gene structure of human GFAP and absence of coding region mutations associated with frontotemporal dementia with parkinsonism linked to chromosome 17. Genomics. 51: 152-4. PMID 9693047 DOI: 10.1006/Geno.1998.5360  0.88
1998 Hutton M, Lendon CL, Rizzu P, Baker M, Froelich S, Houlden H, Pickering-Brown S, Chakraverty S, Isaacs A, Grover A, Hackett J, Adamson J, Lincoln S, Dickson D, Davies P, et al. Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17. Nature. 393: 702-5. PMID 9641683 DOI: 10.1038/31508  0.8
1998 Hardy J, Pérez-Tur J, Baker M, Farrer M, Crook R, Hutton M, Johnson WG, Gwinn K, Muenter M, Rocca WA, Maraganore D. Exclusion of genetic linkage to 4q21-23 and 17q21 in a family with Lewy body parkinsonism. American Journal of Medical Genetics. 81: 166-71. PMID 9613857 DOI: 10.1002/(Sici)1096-8628(19980328)81:2<166::Aid-Ajmg8>3.0.Co;2-U  0.92
1998 Pennypacker KR, Fuldner R, Xu R, Hernandez H, Dawbarn D, Mehta N, Perez-Tur J, Baker M, Hutton M. Cloning and characterization of the presenilin-2 gene promoter. Brain Research. Molecular Brain Research. 56: 57-65. PMID 9602061 DOI: 10.1016/S0169-328X(98)00028-X  0.8
1998 Crook R, Verkkoniemi A, Perez-Tur J, Mehta N, Baker M, Houlden H, Farrer M, Hutton M, Lincoln S, Hardy J, Gwinn K, Somer M, Paetau A, Kalimo H, Ylikoski R, et al. A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1. Nature Medicine. 4: 452-5. PMID 9546792 DOI: 10.1038/Nm0498-452  0.8
1998 Houlden H, Crook R, Backhovens H, Prihar G, Baker M, Hutton M, Rossor M, Martin JJ, Van Broeckhoven C, Hardy J. ApoE genotype is a risk factor in nonpresenilin early-onset Alzheimer's disease families. American Journal of Medical Genetics. 81: 117-21. PMID 9514597 DOI: 10.1002/(Sici)1096-8628(19980207)81:1<117::Aid-Ajmg19>3.0.Co;2-M  0.92
1998 Mehta ND, Refolo LM, Eckman C, Sanders S, Yager D, Perez-Tur J, Younkin S, Duff K, Hardy J, Hutton M. Increased Abeta42(43) from cell lines expressing presenilin 1 mutations. Annals of Neurology. 43: 256-8. PMID 9485068 DOI: 10.1002/Ana.410430217  0.8
1998 Harvey RJ, Ellison D, Hardy J, Hutton M, Roques PK, Collinge J, Fox NC, Rossor MN. Chromosome 14 familial Alzheimer's disease: the clinical and neuropathological characteristics of a family with a leucine-->serine (L250S) substitution at codon 250 of the presenilin 1 gene. Journal of Neurology, Neurosurgery, and Psychiatry. 64: 44-9. PMID 9436726 DOI: 10.1136/Jnnp.64.1.44  0.92
1998 Cruts M, van Duijn CM, Backhovens H, Van den Broeck M, Wehnert A, Serneels S, Sherrington R, Hutton M, Hardy J, St George-Hyslop PH, Hofman A, Van Broeckhoven C. Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease. Human Molecular Genetics. 7: 43-51. PMID 9384602 DOI: 10.1093/Hmg/7.1.43  0.92
1997 Lynch T, Farrer M, Hutton M, Hardy J. Genetics of Parkinson's disease. Science (New York, N.Y.). 278: 1212-3. PMID 9411743  0.92
1997 Baker M, Kwok JB, Kucera S, Crook R, Farrer M, Houlden H, Isaacs A, Lincoln S, Onstead L, Hardy J, Wittenberg L, Dodd P, Webb S, Hayward N, Tannenberg T, ... ... Hutton M, et al. Localization of frontotemporal dementia with parkinsonism in an Australian kindred to chromosome 17q21-22. Annals of Neurology. 42: 794-8. PMID 9392579 DOI: 10.1002/Ana.410420516  0.92
1997 Eckman CB, Mehta ND, Crook R, Perez-tur J, Prihar G, Pfeiffer E, Graff-Radford N, Hinder P, Yager D, Zenk B, Refolo LM, Prada CM, Younkin SG, Hutton M, Hardy J. A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43). Human Molecular Genetics. 6: 2087-9. PMID 9328472 DOI: 10.1093/Hmg/6.12.2087  0.8
1997 Hutton M, Hardy J. The presenilins and Alzheimer's disease. Human Molecular Genetics. 6: 1639-46. PMID 9300655 DOI: 10.1093/Hmg/6.10.1639  0.92
1997 Crook R, Ellis R, Shanks M, Thal LJ, Perez-Tur J, Baker M, Hutton M, Haltia T, Hardy J, Galasko D. Early-onset Alzheimer's disease with a presenilin-1 mutation at the site corresponding to the Volga German presenilin-2 mutation. Annals of Neurology. 42: 124-8. PMID 9225696 DOI: 10.1002/Ana.410420121  0.8
1997 Benkovic SA, McGowan EM, Rothwell NJ, Hutton M, Morgan DG, Gordon MN. Regional and cellular localization of presenilin-2 RNA in rat and human brain. Experimental Neurology. 145: 555-64. PMID 9217091 DOI: 10.1006/Exnr.1997.6487  0.76
1997 Fox NC, Kennedy AM, Harvey RJ, Lantos PL, Roques PK, Collinge J, Hardy J, Hutton M, Stevens JM, Warrington EK, Rossor MN. Clinicopathological features of familial Alzheimer's disease associated with the M139V mutation in the presenilin 1 gene. Pedigree but not mutation specific age at onset provides evidence for a further genetic factor. Brain : a Journal of Neurology. 120: 491-501. PMID 9126060 DOI: 10.1093/Brain/120.3.491  0.8
1996 Clark RF, Hutton M, Talbot C, Wragg M, Lendon C, Busfield F, Han SW, Perez-Tur J, Adams M, Fuldner R, Roberts G, Karran E, Hardy J, Goate A. The role of presenilin 1 in the genetics of Alzheimer's disease. Cold Spring Harbor Symposia On Quantitative Biology. 61: 551-8. PMID 9246481  0.8
1996 Ward RV, Davis JB, Gray CW, Barton AJ, Bresciani LG, Caivano M, Murphy VF, Duff K, Hutton M, Hardy J, Roberts GW, Karran EH. Presenilin-1 is processed into two major cleavage products in neuronal cell lines. Neurodegeneration : a Journal For Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration. 5: 293-8. PMID 9117540 DOI: 10.1006/Neur.1996.0040  0.92
1996 Barton AJ, Crook BW, Karran EH, Brown F, Dewar D, Mann DM, Pearson RC, Graham DI, Hardy J, Hutton M, Duff K, Goate AM, Clark RF, Roberts GW. Alteration in brain presenilin 1 mRNA expression in early onset familial Alzheimer's disease. Neurodegeneration : a Journal For Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration. 5: 213-8. PMID 8910899 DOI: 10.1006/Neur.1996.0029  0.8
1996 Perez-Tur J, Croxton R, Wright K, Phillips H, Zehr C, Crook R, Hutton M, Hardy J, Karran E, Roberts GW, Lancaster S, Haltia T. A further presenilin 1 mutation in the exon 8 cluster in familial Alzheimer's disease. Neurodegeneration : a Journal For Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration. 5: 207-12. PMID 8910898 DOI: 10.1006/Neur.1996.0028  0.8
1996 Prihar G, Fuldner RA, Perez-Tur J, Lincoln S, Duff K, Crook R, Hardy J, Philips CA, Venter C, Talbot C, Clark RF, Goate A, Li J, Potter H, Karran E, ... ... Hutton M, et al. Structure and alternative splicing of the presenilin-2 gene. Neuroreport. 7: 1680-4. PMID 8904781 DOI: 10.1097/00001756-199607080-00031  0.8
1996 Duff K, Eckman C, Zehr C, Yu X, Prada CM, Perez-tur J, Hutton M, Buee L, Harigaya Y, Yager D, Morgan D, Gordon MN, Holcomb L, Refolo L, Zenk B, et al. Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature. 383: 710-3. PMID 8878479 DOI: 10.1038/383710A0  0.8
1996 Mann DM, Iwatsubo T, Cairns NJ, Lantos PL, Nochlin D, Sumi SM, Bird TD, Poorkaj P, Hardy J, Hutton M, Prihar G, Crook R, Rossor MN, Haltia M. Amyloid beta protein (Abeta) deposition in chromosome 14-linked Alzheimer's disease: predominance of Abeta42(43). Annals of Neurology. 40: 149-56. PMID 8773595 DOI: 10.1002/Ana.410400205  0.92
1996 Hutton M, Busfield F, Wragg M, Crook R, Perez-Tur J, Clark RF, Prihar G, Talbot C, Phillips H, Wright K, Baker M, Lendon C, Duff K, Martinez A, Houlden H, et al. Complete analysis of the presenilin 1 gene in early onset Alzheimer's disease. Neuroreport. 7: 801-5. PMID 8733749  0.8
1996 Talbot C, Houlden H, Craddock N, Crook R, Hutton M, Lendon C, Prihar G, Morris JC, Hardy J, Goate A. Polymorphism in AACT gene may lower age of onset of Alzheimer's disease. Neuroreport. 7: 534-6. PMID 8730823 DOI: 10.1097/00001756-199601310-00038  0.92
1996 Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, et al. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Medicine. 2: 864-70. PMID 8705854 DOI: 10.1038/Nm0896-864  0.8
1996 Wragg M, Hutton M, Talbot C. Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease. Alzheimer's Disease Collaborative Group. Lancet. 347: 509-12. PMID 8596269 DOI: 10.1016/S0140-6736(96)91140-X  0.44
1995 Hardy J, Hutton M. Two new genes for Alzheimer's disease. Trends in Neurosciences. 18: 436. PMID 8545905 DOI: 10.1016/0166-2236(95)90092-6  0.92
1995 Houlden H, Crook R, Duff K, Hutton M, Collinge J, Roques P, Rossor M, Hardy J. Apolipoprotein E alleles but neither apolipoprotein B nor apolipoprotein AI/CIII alleles are associated with late onset, familial Alzheimer's disease. Neuroscience Letters. 188: 202-4. PMID 7609909 DOI: 10.1016/0304-3940(95)11422-S  0.92
1994 Rempfer R, Crook R, Houlden H, Duff K, Hutton M, Roberts GW, Raghavan R, Perry R, Hardy J. Parkinson's disease, but not Alzheimer's disease, Lewy body variant associated with mutant alleles at cytochrome P450 gene. Lancet. 344: 815. PMID 7916091 DOI: 10.1016/S0140-6736(94)92370-1  0.92
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