Lin Guo - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 

36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Guo L, Mann JR, Mauna JC, Copley KE, Wang H, Rubien JD, Odeh HM, Lin J, Lee BL, Ganser L, Robinson E, Kim KM, Murthy AC, Paul T, Portz B, et al. Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains. Biorxiv : the Preprint Server For Biology. PMID 37732211 DOI: 10.1101/2023.09.04.555754  0.706
2023 Sharma K, Banerjee S, Savran D, Rajes C, Wiese S, Girdhar A, Schwierz N, Lee C, Shorter J, Schmidt M, Guo L, Fändrich M. Cryo-EM structure of the full-length hnRNPA1 amyloid fibril. Journal of Molecular Biology. 168211. PMID 37481159 DOI: 10.1016/j.jmb.2023.168211  0.806
2022 Gao J, Mewborne QT, Girdhar A, Sheth U, Coyne AN, Punathil R, Kang BG, Dasovich M, Veire A, DeJesus Hernandez M, Liu S, Shi Z, Dafinca R, Fouquerel E, Talbot K, ... ... Guo L, et al. Poly(ADP-ribose) promotes toxicity of arginine-rich dipeptide repeat proteins. Science Translational Medicine. 14: eabq3215. PMID 36103513 DOI: 10.1126/scitranslmed.abq3215  0.745
2022 Girdhar A, Guo L. Regulating Phase Transition in Neurodegenerative Diseases by Nuclear Import Receptors. Biology. 11. PMID 36101390 DOI: 10.3390/biology11071009  0.804
2022 Kim HJ, Mohassel P, Donkervoort S, Guo L, O'Donovan K, Coughlin M, Lornage X, Foulds N, Hammans SR, Foley AR, Fare CM, Ford AF, Ogasawara M, Sato A, Iida A, et al. Heterozygous frameshift variants in HNRNPA2B1 cause early-onset oculopharyngeal muscular dystrophy. Nature Communications. 13: 2306. PMID 35484142 DOI: 10.1038/s41467-022-30015-1  0.772
2022 Carey JL, Guo L. Liquid-Liquid Phase Separation of TDP-43 and FUS in Physiology and Pathology of Neurodegenerative Diseases. Frontiers in Molecular Biosciences. 9: 826719. PMID 35187086 DOI: 10.3389/fmolb.2022.826719  0.81
2021 Gottlieb L, Guo L, Shorter J, Marmorstein R. N-alpha-acetylation of Huntingtin protein increases its propensity to aggregate. The Journal of Biological Chemistry. 297: 101363. PMID 34732320 DOI: 10.1016/j.jbc.2021.101363  0.498
2021 Beijer D, Kim HJ, Guo L, O'Donovan K, Mademan I, Deconinck T, Van Schil K, Fare CM, Drake LE, Ford AF, Kochański A, Kabzińska D, Dubuisson N, Van den Bergh P, Voermans NC, et al. Characterization of HNRNPA1 mutations defines diversity in pathogenic mechanisms and clinical presentation. Jci Insight. 6. PMID 34291734 DOI: 10.1172/jci.insight.148363  0.773
2021 Yoshizawa T, Guo L. Karyopherin-βs play a key role as a phase separation regulator. Journal of Biochemistry. PMID 34223614 DOI: 10.1093/jb/mvab072  0.338
2020 Robinson E, Shorter J, Guo L. Karyopherin-β2 Inhibits and Reverses Aggregation and Liquid-liquid Phase Separation of the ALS/FTD-Associated Protein FUS. Bio-Protocol. 10: e3725. PMID 33659387 DOI: 10.21769/BioProtoc.3725  0.728
2019 Niaki AG, Sarkar J, Cai X, Rhine K, Vidaurre V, Guy B, Hurst M, Lee JC, Koh HR, Guo L, Fare CM, Shorter J, Myong S. Loss of Dynamic RNA Interaction and Aberrant Phase Separation Induced by Two Distinct Types of ALS/FTD-Linked FUS Mutations. Molecular Cell. PMID 31630970 DOI: 10.1016/J.Molcel.2019.09.022  0.824
2019 Gasset-Rosa F, Lu S, Yu H, Chen C, Melamed Z, Guo L, Shorter J, Da Cruz S, Cleveland DW. Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death. Neuron. PMID 30853299 DOI: 10.1016/J.Neuron.2019.02.038  0.584
2019 Mann JR, Gleixner AM, Mauna JC, Gomes E, DeChellis-Marks MR, Needham PG, Copley KE, Hurtle B, Portz B, Pyles NJ, Guo L, Calder CB, Wills ZP, Pandey UB, Kofler JK, et al. RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43. Neuron. PMID 30826182 DOI: 10.1016/J.Neuron.2019.01.048  0.798
2019 Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tian R, Chew J, DeTure M, et al. Heterochromatin anomalies and double-stranded RNA accumulation underlie poly(PR) toxicity. Science (New York, N.Y.). 363. PMID 30765536 DOI: 10.1126/Science.Aav2606  0.621
2019 Guo L, Fare CM, Shorter J. Therapeutic Dissolution of Aberrant Phases by Nuclear-Import Receptors. Trends in Cell Biology. PMID 30660504 DOI: 10.1016/J.Tcb.2018.12.004  0.818
2018 McGurk L, Gomes E, Guo L, Shorter J, Bonini N. Poly(ADP-ribose) engages the TDP-43 nuclear-localization sequence to regulate granulo-filamentous aggregation. Biochemistry. PMID 30540446 DOI: 10.1021/Acs.Biochem.8B00910  0.601
2018 McGurk L, Gomes E, Guo L, Mojsilovic-Petrovic J, Tran V, Kalb RG, Shorter J, Bonini NM. Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization. Molecular Cell. PMID 30100264 DOI: 10.1016/J.Molcel.2018.07.002  0.597
2018 Bogaert E, Boeynaems S, Kato M, Guo L, Caulfield TR, Steyaert J, Scheveneels W, Wilmans N, Haeck W, Hersmus N, Schymkowitz J, Rousseau F, Shorter J, Callaerts P, Robberecht W, et al. Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity. Cell Reports. 24: 529-537.e4. PMID 30021151 DOI: 10.1016/J.Celrep.2018.06.070  0.646
2018 Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM, Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, et al. Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Cell. 173: 677-692.e20. PMID 29677512 DOI: 10.1016/J.Cell.2018.03.002  0.772
2018 Zhang T, Wu YC, Mullane P, Ji YJ, Liu H, He L, Arora A, Hwang HY, Alessi AF, Niaki AG, Periz G, Guo L, Wang H, Elkayam E, Joshua-Tor L, et al. FUS Regulates Activity of MicroRNA-Mediated Gene Silencing. Molecular Cell. 69: 787-801.e8. PMID 29499134 DOI: 10.1016/J.Molcel.2018.02.001  0.605
2016 Guo L, Shorter J. Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies. Cold Spring Harbor Perspectives in Medicine. PMID 27920024 DOI: 10.1101/Cshperspect.A024554  0.664
2015 Guo L, Shorter J. It's Raining Liquids: RNA Tunes Viscoelasticity and Dynamics of Membraneless Organelles. Molecular Cell. 60: 189-92. PMID 26474062 DOI: 10.1016/J.Molcel.2015.10.006  0.651
2015 Wang G, Yang H, Yan S, Wang CE, Liu X, Zhao B, Ouyang Z, Yin P, Liu Z, Zhao Y, Liu T, Fan N, Guo L, Li S, Li XJ, et al. Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain. Molecular Neurodegeneration. 10: 42. PMID 26334913 DOI: 10.1186/S13024-015-0036-5  0.346
2014 Guo L, Giasson BI, Glavis-Bloom A, Brewer MD, Shorter J, Gitler AD, Yang X. A cellular system that degrades misfolded proteins and protects against neurodegeneration. Molecular Cell. 55: 15-30. PMID 24882209 DOI: 10.1016/J.Molcel.2014.04.030  0.552
2013 Guo L, Gai F. Simple method to enhance the photostability of the fluorescence reporter R6G for prolonged single-molecule studies. The Journal of Physical Chemistry. A. 117: 6164-70. PMID 23641719 DOI: 10.1021/Jp4003643  0.476
2012 Chow D, Guo L, Gai F, Goulian M. Fluorescence correlation spectroscopy measurements of the membrane protein TetA in Escherichia coli suggest rapid diffusion at short length scales. Plos One. 7: e48600. PMID 23119068 DOI: 10.1371/Journal.Pone.0048600  0.509
2012 Wang YH, Collins A, Guo L, Smith-Dupont KB, Gai F, Svitkina T, Janmey PA. Divalent cation-induced cluster formation by polyphosphoinositides in model membranes. Journal of the American Chemical Society. 134: 3387-95. PMID 22280226 DOI: 10.1021/Ja208640T  0.523
2011 Rogers JM, Polishchuk AL, Guo L, Wang J, DeGrado WF, Gai F. Photoinduced electron transfer and fluorophore motion as a probe of the conformational dynamics of membrane proteins: application to the influenza a M2 proton channel. Langmuir : the Acs Journal of Surfaces and Colloids. 27: 3815-21. PMID 21401044 DOI: 10.1021/La200480D  0.664
2011 Guo L, Smith-Dupont KB, Gai F. Diffusion as a probe of peptide-induced membrane domain formation. Biochemistry. 50: 2291-7. PMID 21332237 DOI: 10.1021/Bi102068J  0.511
2010 Guo L, Gai F. Heterogeneous diffusion of a membrane-bound pHLIP peptide. Biophysical Journal. 98: 2914-22. PMID 20550904 DOI: 10.1016/J.Bpj.2010.03.050  0.486
2010 Smith-Dupont KB, Guo L, Gai F. Diffusion as a probe of the heterogeneity of antimicrobial peptide-membrane interactions. Biochemistry. 49: 4672-8. PMID 20455545 DOI: 10.1021/Bi100426P  0.502
2009 Mukherjee S, Waegele MM, Chowdhury P, Guo L, Gai F. Effect of macromolecular crowding on protein folding dynamics at the secondary structure level. Journal of Molecular Biology. 393: 227-36. PMID 19682997 DOI: 10.1016/J.Jmb.2009.08.016  0.765
2009 Guo L, Park J, Lee T, Chowdhury P, Lim M, Gai F. Probing the role of hydration in the unfolding transitions of carbonmonoxy myoglobin and apomyoglobin. The Journal of Physical Chemistry. B. 113: 6158-63. PMID 19348439 DOI: 10.1021/Jp900009X  0.699
2008 Yang ST, Wang H, Guo L, Gao Y, Liu Y, Cao A. Interaction of fullerenol with lysozyme investigated by experimental and computational approaches. Nanotechnology. 19: 395101. PMID 21832583 DOI: 10.1088/0957-4484/19/39/395101  0.328
2008 Guo L, Chowdhury P, Glasscock JM, Gai F. Denaturant-induced expansion and compaction of a multi-domain protein: IgG. Journal of Molecular Biology. 384: 1029-36. PMID 19004457 DOI: 10.1016/J.Jmb.2008.03.006  0.696
2007 Guo L, Chowdhury P, Fang J, Gai F. Heterogeneous and anomalous diffusion inside lipid tubules. The Journal of Physical Chemistry. B. 111: 14244-9. PMID 18052149 DOI: 10.1021/Jp076562N  0.647
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