Lin Guo - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 

13 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Niaki AG, Sarkar J, Cai X, Rhine K, Vidaurre V, Guy B, Hurst M, Lee JC, Koh HR, Guo L, Fare CM, Shorter J, Myong S. Loss of Dynamic RNA Interaction and Aberrant Phase Separation Induced by Two Distinct Types of ALS/FTD-Linked FUS Mutations. Molecular Cell. PMID 31630970 DOI: 10.1016/j.molcel.2019.09.022  1
2019 Gasset-Rosa F, Lu S, Yu H, Chen C, Melamed Z, Guo L, Shorter J, Da Cruz S, Cleveland DW. Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death. Neuron. PMID 30853299 DOI: 10.1016/j.neuron.2019.02.038  1
2019 Mann JR, Gleixner AM, Mauna JC, Gomes E, DeChellis-Marks MR, Needham PG, Copley KE, Hurtle B, Portz B, Pyles NJ, Guo L, Calder CB, Wills ZP, Pandey UB, Kofler JK, et al. RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43. Neuron. PMID 30826182 DOI: 10.1016/j.neuron.2019.01.048  1
2019 Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tian R, Chew J, DeTure M, et al. Heterochromatin anomalies and double-stranded RNA accumulation underlie poly(PR) toxicity. Science (New York, N.Y.). 363. PMID 30765536 DOI: 10.1126/science.aav2606  1
2019 Guo L, Fare CM, Shorter J. Therapeutic Dissolution of Aberrant Phases by Nuclear-Import Receptors. Trends in Cell Biology. PMID 30660504 DOI: 10.1016/j.tcb.2018.12.004  1
2018 McGurk L, Gomes E, Guo L, Shorter J, Bonini N. Poly(ADP-ribose) engages the TDP-43 nuclear-localization sequence to regulate granulo-filamentous aggregation. Biochemistry. PMID 30540446 DOI: 10.1021/acs.biochem.8b00910  1
2018 McGurk L, Gomes E, Guo L, Mojsilovic-Petrovic J, Tran V, Kalb RG, Shorter J, Bonini NM. Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization. Molecular Cell. PMID 30100264 DOI: 10.1016/j.molcel.2018.07.002  1
2018 Bogaert E, Boeynaems S, Kato M, Guo L, Caulfield TR, Steyaert J, Scheveneels W, Wilmans N, Haeck W, Hersmus N, Schymkowitz J, Rousseau F, Shorter J, Callaerts P, Robberecht W, et al. Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity. Cell Reports. 24: 529-537.e4. PMID 30021151 DOI: 10.1016/j.celrep.2018.06.070  1
2018 Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM, Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, et al. Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Cell. 173: 677-692.e20. PMID 29677512 DOI: 10.1016/j.cell.2018.03.002  1
2018 Zhang T, Wu YC, Mullane P, Ji YJ, Liu H, He L, Arora A, Hwang HY, Alessi AF, Niaki AG, Periz G, Guo L, Wang H, Elkayam E, Joshua-Tor L, et al. FUS Regulates Activity of MicroRNA-Mediated Gene Silencing. Molecular Cell. 69: 787-801.e8. PMID 29499134 DOI: 10.1016/j.molcel.2018.02.001  1
2016 Guo L, Shorter J. Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies. Cold Spring Harbor Perspectives in Medicine. PMID 27920024 DOI: 10.1101/cshperspect.a024554  1
2015 Guo L, Shorter J. It's Raining Liquids: RNA Tunes Viscoelasticity and Dynamics of Membraneless Organelles. Molecular Cell. 60: 189-92. PMID 26474062 DOI: 10.1016/j.molcel.2015.10.006  1
2014 Guo L, Giasson BI, Glavis-Bloom A, Brewer MD, Shorter J, Gitler AD, Yang X. A cellular system that degrades misfolded proteins and protects against neurodegeneration. Molecular Cell. 55: 15-30. PMID 24882209 DOI: 10.1016/j.molcel.2014.04.030  1
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