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Nancy Mara Bonini - Publications

Affiliations: 
Biology University of Pennsylvania, Philadelphia, PA, United States 
Area:
transgenic models for human neurodegenerative disease
Website:
https://www.bio.upenn.edu/people/nancy-bonini

98 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Goodman LD, Bonini NM. New Roles for Canonical Transcription Factors in Repeat Expansion Diseases. Trends in Genetics : Tig. PMID 31837826 DOI: 10.1016/j.tig.2019.11.003  0.747
2019 Goodman LD, Bonini NM. Repeat-associated non-AUG (RAN) translation mechanisms running into focus for GGGGCC-repeat associated ALS/FTD. Progress in Neurobiology. 101697. PMID 31550516 DOI: 10.1016/J.Pneurobio.2019.101697  0.755
2019 Goodman LD, Prudencio M, Kramer NJ, Martinez-Ramirez LF, Srinivasan AR, Lan M, Parisi MJ, Zhu Y, Chew J, Cook CN, Berson A, Gitler AD, Petrucelli L, Bonini NM. Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD. Nature Neuroscience. PMID 31110321 DOI: 10.1038/S41593-019-0396-1  0.779
2019 Berson A, Goodman LD, Sartoris AN, Otte CG, Aykit JA, Lee VM, Trojanowski JQ, Bonini NM. Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies. Acta Neuropathologica Communications. 7: 65. PMID 31036086 DOI: 10.1186/S40478-019-0710-X  0.765
2019 Goodman LD, Prudencio M, Srinivasan AR, Rifai OM, Lee VM, Petrucelli L, Bonini NM. eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS. Acta Neuropathologica Communications. 7: 62. PMID 31023341 DOI: 10.1186/S40478-019-0711-9  0.745
2018 McGurk L, Gomes E, Guo L, Shorter J, Bonini N. Poly(ADP-ribose) engages the TDP-43 nuclear-localization sequence to regulate granulo-filamentous aggregation. Biochemistry. PMID 30540446 DOI: 10.1021/Acs.Biochem.8B00910  0.556
2018 Chung CY, Berson A, Kennerdell JR, Sartoris A, Unger T, Porta S, Kim HJ, Smith ER, Shilatifard A, Van Deerlin V, Lee VM, Chen-Plotkin A, Bonini NM. Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity. Nature Communications. 9: 4406. PMID 30353006 DOI: 10.1038/S41467-018-06543-0  0.41
2018 Kennerdell JR, Liu N, Bonini NM. MiR-34 inhibits polycomb repressive complex 2 to modulate chaperone expression and promote healthy brain aging. Nature Communications. 9: 4188. PMID 30305625 DOI: 10.1038/S41467-018-06592-5  0.447
2018 McGurk L, Mojsilovic-Petrovic J, Van Deerlin VM, Shorter J, Kalb RG, Lee VM, Trojanowski JQ, Lee EB, Bonini NM. Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis. Acta Neuropathologica Communications. 6: 84. PMID 30157956 DOI: 10.1186/S40478-018-0586-1  0.576
2018 McGurk L, Gomes E, Guo L, Mojsilovic-Petrovic J, Tran V, Kalb RG, Shorter J, Bonini NM. Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization. Molecular Cell. PMID 30100264 DOI: 10.1016/J.Molcel.2018.07.002  0.545
2018 Mordes DA, Prudencio M, Goodman LD, Klim JR, Moccia R, Limone F, Pietilainen O, Chowdhary K, Dickson DW, Rademakers R, Bonini NM, Petrucelli L, Eggan K. Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients. Acta Neuropathologica Communications. 6: 55. PMID 29973287 DOI: 10.1186/S40478-018-0555-8  0.754
2018 Berson A, Nativio R, Berger SL, Bonini NM. Epigenetic Regulation in Neurodegenerative Diseases. Trends in Neurosciences. PMID 29885742 DOI: 10.1016/J.Tins.2018.05.005  0.343
2018 Nativio R, Donahue G, Berson A, Lan Y, Amlie-Wolf A, Tuzer F, Toledo JB, Gosai SJ, Gregory BD, Torres C, Trojanowski JQ, Wang LS, Johnson FB, Bonini NM, Berger SL. Publisher Correction: Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease. Nature Neuroscience. PMID 29556027 DOI: 10.1038/S41593-018-0124-2  0.568
2018 Nativio R, Donahue G, Berson A, Lan Y, Amlie-Wolf A, Tuzer F, Toledo JB, Gosai SJ, Gregory BD, Torres C, Trojanowski JQ, Wang LS, Johnson FB, Bonini NM, Berger SL. Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease. Nature Neuroscience. PMID 29507413 DOI: 10.1038/S41593-018-0101-9  0.582
2017 Berson A, Sartoris A, Nativio R, Van Deerlin V, Toledo JB, Porta S, Liu S, Chung CY, Garcia BA, Lee VM, Trojanowski JQ, Johnson FB, Berger SL, Bonini NM. TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling. Current Biology : Cb. PMID 29153328 DOI: 10.1016/J.Cub.2017.10.024  0.35
2017 Kim SA, D'Acunto VF, Kokona B, Hofmann J, Cunningham NR, Bistline EM, Garcia FJ, Akhtar NM, Hoffman SH, Doshi SH, Ulrich KM, Jones NM, Bonini N, Roberts CM, Link CD, et al. Sedimentation Velocity Analysis With Fluorescence Detection of Mutant Huntingtin Exon 1 Aggregation in Drosophila Melanogaster and Caenorhabditis Elegans. Biochemistry. PMID 28786671 DOI: 10.1021/Acs.Biochem.7B00518  0.335
2016 Sproviero W, Shatunov A, Stahl D, Shoai M, van Rheenen W, Jones AR, Al-Sarraj S, Andersen PM, Bonini NM, Conforti FL, Van Damme P, Daoud H, Del Mar Amador M, Fogh I, Forzan M, et al. ATXN2 trinucleotide repeat length correlates with risk of ALS. Neurobiology of Aging. PMID 28017481 DOI: 10.1016/J.Neurobiolaging.2016.11.010  0.581
2016 Crowe EP, Tuzer F, Gregory BD, Donahue G, Gosai SJ, Cohen J, Leung YY, Yetkin E, Nativio R, Wang LS, Sell C, Bonini NM, Berger SL, Johnson FB, Torres C. Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-Induced Senescence. Frontiers in Aging Neuroscience. 8: 208. PMID 27630559 DOI: 10.3389/Fnagi.2016.00208  0.625
2016 Kramer NJ, Carlomagno Y, Zhang YJ, Almeida S, Cook CN, Gendron TF, Prudencio M, Van Blitterswijk M, Belzil V, Couthouis J, Paul JW, Goodman LD, Daughrity L, Chew J, Garrett A, ... ... Bonini NM, et al. Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts. Science (New York, N.Y.). 353: 708-12. PMID 27516603 DOI: 10.1126/Science.Aaf7791  0.78
2016 Perrimon N, Bonini NM, Dhillon P. Fruit flies on the front line: the translational impact of Drosophila. Disease Models & Mechanisms. 9: 229-31. PMID 26935101 DOI: 10.1242/dmm.024810  0.325
2015 Schweizer Burguete A, Almeida S, Gao FB, Kalb R, Akins MR, Bonini NM. GGGGCC microsatellite RNA is neuritically localized, induces branching defects, and perturbs transport granule function. Elife. 4. PMID 26650351 DOI: 10.7554/Elife.08881  0.358
2015 Fang Y, Bonini NM. Hope on the (fruit) fly: the Drosophila wing paradigm of axon injury. Neural Regeneration Research. 10: 173-5. PMID 25883604 DOI: 10.4103/1673-5374.152359  0.315
2015 Feltzin VL, Khaladkar M, Abe M, Parisi M, Hendriks GJ, Kim J, Bonini NM. The exonuclease Nibbler regulates age-associated traits and modulates piRNA length in Drosophila. Aging Cell. 14: 443-52. PMID 25754031 DOI: 10.1111/Acel.12323  0.595
2015 Bonini NM, Hardiman O. Ataxin-2 expands insight into the ALS clinical spectrum. Neurology. 84: 224-5. PMID 25527266 DOI: 10.1212/Wnl.0000000000001167  0.328
2015 Yu Z, Goodman LD, Shieh SY, Min M, Teng X, Zhu Y, Bonini NM. A fly model for the CCUG-repeat expansion of myotonic dystrophy type 2 reveals a novel interaction with MBNL1. Human Molecular Genetics. 24: 954-62. PMID 25305073 DOI: 10.1093/Hmg/Ddu507  0.784
2015 Chen Q, Crowe EP, Kuhn T, Johnson JE, Gregory BD, Donahue G, Bonini NM, Berger SL, Sell C, Torres C, Brad Johnson F. Connections between cell senescence, chromatin, and neurodegeneration Experimental Gerontology. 68: 93-94. DOI: 10.1016/J.Exger.2015.01.011  0.563
2014 McGurk L, Lee VM, Trojanowksi JQ, Van Deerlin VM, Lee EB, Bonini NM. Poly-A binding protein-1 localization to a subset of TDP-43 inclusions in amyotrophic lateral sclerosis occurs more frequently in patients harboring an expansion in C9orf72. Journal of Neuropathology and Experimental Neurology. 73: 837-45. PMID 25111021 DOI: 10.1097/Nen.0000000000000102  0.383
2014 Abe M, Naqvi A, Hendriks GJ, Feltzin V, Zhu Y, Grigoriev A, Bonini NM. Impact of age-associated increase in 2'-O-methylation of miRNAs on aging and neurodegeneration in Drosophila. Genes & Development. 28: 44-57. PMID 24395246 DOI: 10.1101/Gad.226654.113  0.768
2014 Kim HJ, Raphael AR, LaDow ES, McGurk L, Weber RA, Trojanowski JQ, Lee VM, Finkbeiner S, Gitler AD, Bonini NM. Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models. Nature Genetics. 46: 152-60. PMID 24336168 DOI: 10.1038/Ng.2853  0.624
2013 Cushman-Nick M, Bonini NM, Shorter J. Hsp104 suppresses polyglutamine-induced degeneration post onset in a drosophila MJD/SCA3 model. Plos Genetics. 9: e1003781. PMID 24039611 DOI: 10.1371/Journal.Pgen.1003781  0.776
2013 Fang Y, Soares L, Bonini NM. Design and implementation of in vivo imaging of neural injury responses in the adult Drosophila wing. Nature Protocols. 8: 810-9. PMID 23589940 DOI: 10.1038/Nprot.2013.042  0.317
2013 Abe M, Bonini NM. MicroRNAs and neurodegeneration: role and impact. Trends in Cell Biology. 23: 30-6. PMID 23026030 DOI: 10.1016/J.Tcb.2012.08.013  0.627
2012 Fang Y, Bonini NM. Axon degeneration and regeneration: insights from Drosophila models of nerve injury. Annual Review of Cell and Developmental Biology. 28: 575-97. PMID 22831639 DOI: 10.1146/Annurev-Cellbio-101011-155836  0.308
2012 Couthouis J, Hart MP, Erion R, King OD, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Mojsilovic-Petrovic J, Panossian S, Kim CE, Frackelton EC, Solski JA, Williams KL, Clay-Falcone D, ... ... Bonini NM, et al. Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis. Human Molecular Genetics. 21: 2899-911. PMID 22454397 DOI: 10.1093/Hmg/Dds116  0.724
2012 Fang Y, Soares L, Teng X, Geary M, Bonini NM. A novel Drosophila model of nerve injury reveals an essential role of Nmnat in maintaining axonal integrity. Current Biology : Cb. 22: 590-5. PMID 22425156 DOI: 10.1016/J.Cub.2012.01.065  0.322
2012 Liu N, Landreh M, Cao K, Abe M, Hendriks GJ, Kennerdell JR, Zhu Y, Wang LS, Bonini NM. The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila. Nature. 482: 519-23. PMID 22343898 DOI: 10.1038/Nature10810  0.641
2011 Couthouis J, Hart MP, Shorter J, DeJesus-Hernandez M, Erion R, Oristano R, Liu AX, Ramos D, Jethava N, Hosangadi D, Epstein J, Chiang A, Diaz Z, Nakaya T, Ibrahim F, ... ... Bonini NM, et al. A yeast functional screen predicts new candidate ALS disease genes. Proceedings of the National Academy of Sciences of the United States of America. 108: 20881-90. PMID 22065782 DOI: 10.1073/Pnas.1109434108  0.718
2011 Liu N, Abe M, Sabin LR, Hendriks GJ, Naqvi AS, Yu Z, Cherry S, Bonini NM. The exoribonuclease Nibbler controls 3' end processing of microRNAs in Drosophila. Current Biology : Cb. 21: 1888-93. PMID 22055292 DOI: 10.1016/J.Cub.2011.10.006  0.77
2011 Shieh SY, Bonini NM. Genes and pathways affected by CAG-repeat RNA-based toxicity in Drosophila. Human Molecular Genetics. 20: 4810-21. PMID 21933837 DOI: 10.1093/Hmg/Ddr420  0.744
2011 Yu Z, Bonini NM. Modeling human trinucleotide repeat diseases in Drosophila. International Review of Neurobiology. 99: 191-212. PMID 21906541 DOI: 10.1016/B978-0-12-387003-2.00008-2  0.407
2011 Bonini NM, Gitler AD. Model organisms reveal insight into human neurodegenerative disease: ataxin-2 intermediate-length polyglutamine expansions are a risk factor for ALS. Journal of Molecular Neuroscience : Mn. 45: 676-83. PMID 21660502 DOI: 10.1007/S12031-011-9548-9  0.558
2011 Lee T, Li YR, Chesi A, Hart MP, Ramos D, Jethava N, Hosangadi D, Epstein J, Hodges B, Bonini NM, Gitler AD. Evaluating the prevalence of polyglutamine repeat expansions in amyotrophic lateral sclerosis. Neurology. 76: 2062-5. PMID 21562248 DOI: 10.1212/Wnl.0B013E31821F4447  0.602
2011 Yu Z, Zhu Y, Chen-Plotkin AS, Clay-Falcone D, McCluskey L, Elman L, Kalb RG, Trojanowski JQ, Lee VM, Van Deerlin VM, Gitler AD, Bonini NM. PolyQ repeat expansions in ATXN2 associated with ALS are CAA interrupted repeats. Plos One. 6: e17951. PMID 21479228 DOI: 10.1371/Journal.Pone.0017951  0.611
2011 Yu Z, Teng X, Bonini NM. Triplet repeat-derived siRNAs enhance RNA-mediated toxicity in a Drosophila model for myotonic dystrophy. Plos Genetics. 7: e1001340. PMID 21437269 DOI: 10.1371/journal.pgen.1001340  0.407
2011 Lee T, Li YR, Ingre C, Weber M, Grehl T, Gredal O, de Carvalho M, Meyer T, Tysnes OB, Auburger G, Gispert S, Bonini NM, Andersen PM, Gitler AD. Ataxin-2 intermediate-length polyglutamine expansions in European ALS patients. Human Molecular Genetics. 20: 1697-700. PMID 21292779 DOI: 10.1093/Hmg/Ddr045  0.596
2011 Jung J, van Jaarsveld MT, Shieh SY, Xu K, Bonini NM. Defining genetic factors that modulate intergenerational CAG repeat instability in Drosophila melanogaster. Genetics. 187: 61-71. PMID 21041558 DOI: 10.1534/Genetics.110.121418  0.732
2010 Elden AC, Kim HJ, Hart MP, Chen-Plotkin AS, Johnson BS, Fang X, Armakola M, Geser F, Greene R, Lu MM, Padmanabhan A, Clay-Falcone D, McCluskey L, Elman L, Juhr D, ... ... Bonini NM, et al. Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS. Nature. 466: 1069-75. PMID 20740007 DOI: 10.1038/Nature09320  0.628
2010 Li LB, Bonini NM. Roles of trinucleotide-repeat RNA in neurological disease and degeneration. Trends in Neurosciences. 33: 292-8. PMID 20398949 DOI: 10.1016/J.Tins.2010.03.004  0.568
2010 Bilen J, Bonini NM. Using Drosophila to Reveal Insight into Protein Misfolding Diseases Protein Misfolding Diseases: Current and Emerging Principles and Therapies. 191-211. DOI: 10.1002/9780470572702.ch10  0.751
2009 Jung J, Xu K, Lessing D, Bonini NM. Preventing Ataxin-3 protein cleavage mitigates degeneration in a Drosophila model of SCA3. Human Molecular Genetics. 18: 4843-52. PMID 19783548 DOI: 10.1093/Hmg/Ddp456  0.413
2009 Lessing D, Bonini NM. Maintaining the brain: insight into human neurodegeneration from Drosophila melanogaster mutants. Nature Reviews. Genetics. 10: 359-70. PMID 19434080 DOI: 10.1038/Nrg2563  0.384
2008 van der Brug MP, Blackinton J, Chandran J, Hao LY, Lal A, Mazan-Mamczarz K, Martindale J, Xie C, Ahmad R, Thomas KJ, Beilina A, Gibbs JR, Ding J, Myers AJ, Zhan M, ... ... Bonini NM, et al. RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways. Proceedings of the National Academy of Sciences of the United States of America. 105: 10244-9. PMID 18626009 DOI: 10.1073/Pnas.0708518105  0.374
2008 Watson MR, Lagow RD, Xu K, Zhang B, Bonini NM. A drosophila model for amyotrophic lateral sclerosis reveals motor neuron damage by human SOD1. The Journal of Biological Chemistry. 283: 24972-81. PMID 18596033 DOI: 10.1074/Jbc.M804817200  0.664
2008 Li LB, Yu Z, Teng X, Bonini NM. RNA toxicity is a component of ataxin-3 degeneration in Drosophila. Nature. 453: 1107-11. PMID 18449188 DOI: 10.1038/Nature06909  0.565
2008 Lessing D, Bonini NM. Polyglutamine genes interact to modulate the severity and progression of neurodegeneration in Drosophila. Plos Biology. 6: e29. PMID 18271626 DOI: 10.1371/Journal.Pbio.0060029  0.429
2007 Li LB, Xu K, Bonini NM. Suppression of polyglutamine toxicity by the yeast Sup35 prion domain in Drosophila. The Journal of Biological Chemistry. 282: 37694-701. PMID 17956866 DOI: 10.1074/Jbc.M705211200  0.533
2007 Bilen J, Bonini NM. Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila. Plos Genetics. 3: 1950-64. PMID 17953484 DOI: 10.1371/Journal.Pgen.0030177  0.761
2007 Jung J, Bonini N. CREB-binding protein modulates repeat instability in a Drosophila model for polyQ disease. Science (New York, N.Y.). 315: 1857-9. PMID 17332375 DOI: 10.1126/science.1139517  0.397
2006 Liu N, Bonini NM. Hosting neurotoxicity in polyglutamine disease. Cell. 127: 1299-300. PMID 17190592 DOI: 10.1016/J.Cell.2006.12.012  0.513
2006 Bilen J, Liu N, Bonini NM. A new role for microRNA pathways: modulation of degeneration induced by pathogenic human disease proteins. Cell Cycle (Georgetown, Tex.). 5: 2835-8. PMID 17172864 DOI: 10.4161/Cc.5.24.3579  0.787
2006 Bilen J, Liu N, Burnett BG, Pittman RN, Bonini NM. MicroRNA pathways modulate polyglutamine-induced neurodegeneration. Molecular Cell. 24: 157-63. PMID 17018300 DOI: 10.1016/J.Molcel.2006.07.030  0.786
2006 Meulener MC, Xu K, Thomson L, Thompson L, Ischiropoulos H, Bonini NM. Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging. Proceedings of the National Academy of Sciences of the United States of America. 103: 12517-22. PMID 16894167 DOI: 10.1073/Pnas.0601891103  0.776
2006 Cooper AA, Gitler AD, Cashikar A, Haynes CM, Hill KJ, Bhullar B, Liu K, Xu K, Strathearn KE, Liu F, Cao S, Caldwell KA, Caldwell GA, Marsischky G, Kolodner RD, ... ... Bonini NM, et al. Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science (New York, N.Y.). 313: 324-8. PMID 16794039 DOI: 10.1126/Science.1129462  0.691
2006 Boeddrich A, Gaumer S, Haacke A, Tzvetkov N, Albrecht M, Evert BO, Müller EC, Lurz R, Breuer P, Schugardt N, Plassmann S, Xu K, Warrick JM, Suopanki J, Wüllner U, ... ... Bonini NM, et al. An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis. The Embo Journal. 25: 1547-58. PMID 16525503 DOI: 10.1038/sj.emboj.7601043  0.61
2006 Uryu K, Richter-Landsberg C, Welch W, Sun E, Goldbaum O, Norris EH, Pham CT, Yazawa I, Hilburger K, Micsenyi M, Giasson BI, Bonini NM, Lee VM, Trojanowski JQ. Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies. The American Journal of Pathology. 168: 947-61. PMID 16507910 DOI: 10.2353/Ajpath.2006.050770  0.311
2006 Giasson BI, Covy JP, Bonini NM, Hurtig HI, Farrer MJ, Trojanowski JQ, Van Deerlin VM. Biochemical and pathological characterization of Lrrk2. Annals of Neurology. 59: 315-22. PMID 16437584 DOI: 10.1002/Ana.20791  0.344
2005 Bilen J, Bonini NM. Drosophila as a model for human neurodegenerative disease. Annual Review of Genetics. 39: 153-71. PMID 16285856 DOI: 10.1146/Annurev.Genet.39.110304.095804  0.761
2005 Bonini NM, Giasson BI. Snaring the function of alpha-synuclein. Cell. 123: 359-61. PMID 16269324 DOI: 10.1016/J.Cell.2005.10.017  0.348
2005 Meulener M, Whitworth AJ, Armstrong-Gold CE, Rizzu P, Heutink P, Wes PD, Pallanck LJ, Bonini NM. Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease. Current Biology : Cb. 15: 1572-7. PMID 16139213 DOI: 10.1016/J.Cub.2005.07.064  0.775
2005 Meulener MC, Graves CL, Sampathu DM, Armstrong-Gold CE, Bonini NM, Giasson BI. DJ-1 is present in a large molecular complex in human brain tissue and interacts with alpha-synuclein. Journal of Neurochemistry. 93: 1524-32. PMID 15935068 DOI: 10.1111/J.1471-4159.2005.03145.X  0.802
2005 Warrick JM, Morabito LM, Bilen J, Gordesky-Gold B, Faust LZ, Paulson HL, Bonini NM. Ataxin-3 suppresses polyglutamine neurodegeneration in Drosophila by a ubiquitin-associated mechanism. Molecular Cell. 18: 37-48. PMID 15808507 DOI: 10.1016/J.Molcel.2005.02.030  0.796
2005 Auluck PK, Meulener MC, Bonini NM. Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila. The Journal of Biological Chemistry. 280: 2873-8. PMID 15556931 DOI: 10.1074/jbc.M412106200  0.77
2003 Gunawardena S, Her LS, Brusch RG, Laymon RA, Niesman IR, Gordesky-Gold B, Sintasath L, Bonini NM, Goldstein LS. Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila. Neuron. 40: 25-40. PMID 14527431 DOI: 10.1016/S0896-6273(03)00594-4  0.325
2003 Bonini NM, Fortini ME. Human neurodegenerative disease modeling using Drosophila. Annual Review of Neuroscience. 26: 627-56. PMID 12704223 DOI: 10.1146/annurev.neuro.26.041002.131425  0.385
2003 Atchison L, Ghias A, Wilkinson F, Bonini N, Atchison ML. Transcription factor YY1 functions as a PcG protein in vivo. The Embo Journal. 22: 1347-58. PMID 12628927 DOI: 10.1093/emboj/cdg124  0.352
2002 Auluck PK, Bonini NM. Pharmacological prevention of Parkinson disease in Drosophila. Nature Medicine. 8: 1185-6. PMID 12411925 DOI: 10.1038/nm1102-1185  0.704
2002 Chan HYE, Warrick JM, Andriola I, Merry D, Bonini NM. Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells Human Molecular Genetics. 11: 2905-2917. PMID 12393802 DOI: 10.1093/Hmg/11.23.2905  0.528
2002 Chan HY, Warrick JM, Andriola I, Merry D, Bonini NM. Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila. Human Molecular Genetics. 11: 2895-904. PMID 12393801 DOI: 10.1093/Hmg/11.23.2895  0.627
2002 Auluck PK, Chan HY, Trojanowski JQ, Lee VM, Bonini NM. Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. Science (New York, N.Y.). 295: 865-8. PMID 11823645 DOI: 10.1126/Science.1067389  0.747
2000 Chan HY, Warrick JM, Gray-Board GL, Paulson HL, Bonini NM. Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila. Human Molecular Genetics. 9: 2811-20. PMID 11092757 DOI: 10.1093/Hmg/9.19.2811  0.657
2000 Paulson HL, Bonini NM, Roth KA. Polyglutamine disease and neuronal cell death. Proceedings of the National Academy of Sciences of the United States of America. 97: 12957-8. PMID 11058149 DOI: 10.1073/pnas.210395797  0.398
2000 Fortini ME, Bonini NM. Modeling human neurodegenerative diseases in Drosophila: on a wing and a prayer. Trends in Genetics : Tig. 16: 161-7. PMID 10729831 DOI: 10.1016/S0168-9525(99)01939-3  0.393
1999 Warrick JM, Chan HY, Gray-Board GL, Chai Y, Paulson HL, Bonini NM. Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70. Nature Genetics. 23: 425-8. PMID 10581028 DOI: 10.1038/70532  0.658
1999 Bonini NM, Fortini ME. Surviving Drosophila eye development: integrating cell death with differentiation during formation of a neural structure. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 21: 991-1003. PMID 10580984 DOI: 10.1002/(SICI)1521-1878(199912)22:1<991::AID-BIES3>3.0.CO;2-3  0.303
1999 Chai Y, Koppenhafer SL, Bonini NM, Paulson HL. Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 10338-47. PMID 10575031 DOI: 10.1523/Jneurosci.19-23-10338.1999  0.401
1998 Perez MK, Paulson HL, Pendse SJ, Saionz SJ, Bonini NM, Pittman RN. Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation. The Journal of Cell Biology. 143: 1457-70. PMID 9852144 DOI: 10.1083/jcb.143.6.1457  0.398
1998 Warrick JM, Paulson HL, Gray-Board GL, Bui QT, Fischbeck KH, Pittman RN, Bonini NM. Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila. Cell. 93: 939-49. PMID 9635424 DOI: 10.1016/S0092-8674(00)81200-3  0.667
1998 Leiserson WM, Benzer S, Bonini NM. Dual functions of the Drosophila eyes absent gene in the eye and embryo. Mechanisms of Development. 73: 193-202. PMID 9622628 DOI: 10.1016/S0925-4773(98)00052-5  0.731
1998 Bonini NM, Leiserson WM, Benzer S. Multiple roles of the eyes absent gene in Drosophila. Developmental Biology. 196: 42-57. PMID 9527880 DOI: 10.1006/dbio.1997.8845  0.747
1997 Bonini NM, Bui QT, Gray-Board GL, Warrick JM. The Drosophila eyes absent gene directs ectopic eye formation in a pathway conserved between flies and vertebrates. Development (Cambridge, England). 124: 4819-26. PMID 9428418  0.527
1997 Zimmerman JE, Bui QT, Steingrímsson E, Nagle DL, Fu W, Genin A, Spinner NB, Copeland NG, Jenkins NA, Bucan M, Bonini NM. Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene. Genome Research. 7: 128-41. PMID 9049631 DOI: 10.1101/Gr.7.2.128  0.317
1995 Bonini NM, Choi KW. Early decisions in Drosophila eye morphogenesis. Current Opinion in Genetics & Development. 5: 507-15. PMID 7580144 DOI: 10.1016/0959-437X(95)90056-M  0.527
1994 Leiserson WM, Bonini NM, Benzer S. Transvection at the eyes absent gene of Drosophila. Genetics. 138: 1171-9. PMID 7896099  0.717
1993 Bonini NM, Leiserson WM, Benzer S. The eyes absent gene: genetic control of cell survival and differentiation in the developing Drosophila eye. Cell. 72: 379-95. PMID 8431945 DOI: 10.1016/0092-8674(93)90115-7  0.729
1991 Bonini NM, Evans TC, Miglietta LA, Nelson DL. The regulation of ciliary motility in Paramecium by Ca2+ and cyclic nucleotides. Advances in Second Messenger and Phosphoprotein Research. 23: 227-72. PMID 1997042  0.346
1990 Bonini NM, Nelson DL. Phosphoproteins associated with cyclic nucleotide stimulation of ciliary motility in Paramecium. Journal of Cell Science. 95: 219-30. PMID 2164518  0.395
1988 Bonini NM, Nelson DL. Differential regulation of Paramecium ciliary motility by cAMP and cGMP. The Journal of Cell Biology. 106: 1615-23. PMID 2836435 DOI: 10.1083/Jcb.106.5.1615  0.453
1986 Bonini NM, Gustin MC, Nelson DL. Regulation of ciliary motility by membrane potential in Paramecium: a role for cyclic AMP. Cell Motility and the Cytoskeleton. 6: 256-72. PMID 2427226 DOI: 10.1002/Cm.970060303  0.43
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