Stuart A. Lipton - Publications

Scripps Research Institute, La Jolla, La Jolla, CA, United States 
 Neurosciences University of California, San Diego, La Jolla, CA 
Neurodegenerative Disease

279 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Oh CK, Nakamura T, Beutler N, Zhang X, Piña-Crespo J, Talantova M, Ghatak S, Trudler D, Carnevale LN, McKercher SR, Bakowski MA, Diedrich JK, Roberts AJ, Woods AK, Chi V, ... ... Lipton SA, et al. Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection. Nature Chemical Biology. PMID 36175661 DOI: 10.1038/s41589-022-01149-6  0.677
2022 Oh CK, Nakamura T, Beutler N, Zhang X, Piña-Crespo J, Talantova M, Ghatak S, Trudler D, Carnevale LN, McKercher SR, Bakowski MA, Diedrich JK, Roberts AJ, Woods AK, Chi V, ... ... Lipton SA, et al. Targeted protein S-nitrosylation of ACE2 as potential treatment to prevent spread of SARS-CoV-2 infection. Biorxiv : the Preprint Server For Biology. PMID 35411336 DOI: 10.1101/2022.04.05.487060  0.676
2021 Trudler D, Sanz-Blasco S, Eisele YS, Ghatak S, Bodhinathan K, Akhtar MW, Lynch WP, Piña-Crespo JC, Talantova M, Kelly JW, Lipton SA. α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 33483428 DOI: 10.1523/JNEUROSCI.1871-20.2020  0.801
2020 Ghatak S, Dolatabadi N, Gao R, Wu Y, Scott H, Trudler D, Sultan A, Ambasudhan R, Nakamura T, Masliah E, Talantova M, Voytek B, Lipton SA. NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models. Molecular Psychiatry. PMID 32467645 DOI: 10.1038/S41380-020-0776-7  0.326
2019 Ghatak S, Dolatabadi N, Trudler D, Zhang X, Wu Y, Mohata M, Ambasudhan R, Talantova M, Lipton SA. Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs. isogenic control. Elife. 8. PMID 31782729 DOI: 10.7554/Elife.50333  0.362
2019 Nakamura T, Lipton SA. Nitric Oxide-Dependent Protein Posttranslational Modifications Impair Mitochondrial Function and Metabolism to Contribute to Neurodegenerative Diseases. Antioxidants & Redox Signaling. PMID 31657228 DOI: 10.1089/ars.2019.7916  0.309
2019 Okamoto SI, Prikhodko O, Pina-Crespo J, Adame A, McKercher SR, Brill LM, Nakanishi N, Oh CK, Nakamura T, Masliah E, Lipton SA. NitroSynapsin for the treatment of neurological manifestations of tuberous sclerosis complex in a rodent model. Neurobiology of Disease. PMID 30928642 DOI: 10.1016/J.Nbd.2019.03.029  0.721
2019 Trudler D, Lipton SA. Novel Direct Conversion of Microglia to Neurons. Trends in Molecular Medicine. PMID 30611669 DOI: 10.1016/j.molmed.2018.12.005  0.351
2019 Ghatak S, Dolatabadi N, Trudler D, Zhang X, Wu Y, Mohata M, Ambasudhan R, Talantova M, Lipton SA. Author response: Mechanisms of hyperexcitability in Alzheimer’s disease hiPSC-derived neurons and cerebral organoids vs isogenic controls Elife. DOI: 10.7554/Elife.50333.Sa2  0.333
2018 Ryan T, Bamm VV, Stykel MG, Coackley CL, Humphries KM, Jamieson-Williams R, Ambasudhan R, Mosser DD, Lipton SA, Harauz G, Ryan SD. Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein. Nature Communications. 9: 817. PMID 29483518 DOI: 10.1038/S41467-018-03241-9  0.592
2017 Connolly NMC, Theurey P, Adam-Vizi V, Bazan NG, Bernardi P, Bolaños JP, Culmsee C, Dawson VL, Deshmukh M, Duchen MR, Düssmann H, Fiskum G, Galindo MF, Hardingham GE, Hardwick JM, ... ... Lipton SA, et al. Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases. Cell Death and Differentiation. PMID 29229998 DOI: 10.1038/S41418-017-0020-4  0.534
2017 Oh CK, Sultan A, Platzer J, Dolatabadi N, Soldner F, McClatchy DB, Diedrich JK, Yates JR, Ambasudhan R, Nakamura T, Jaenisch R, Lipton SA. S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson's Disease Models. Cell Reports. 21: 2171-2182. PMID 29166608 DOI: 10.1016/J.Celrep.2017.10.068  0.337
2017 Tu S, Akhtar MW, Escorihuela RM, Amador-Arjona A, Swarup V, Parker J, Zaremba JD, Holland T, Bansal N, Holohan DR, Lopez K, Ryan SD, Chan SF, Yan L, Zhang X, ... ... Lipton SA, et al. NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism. Nature Communications. 8: 1488. PMID 29133852 DOI: 10.1038/S41467-017-01563-8  0.725
2017 Nakamura T, Lipton SA. 'SNO'-Storms Compromise Protein Activity and Mitochondrial Metabolism in Neurodegenerative Disorders. Trends in Endocrinology and Metabolism: Tem. PMID 29097102 DOI: 10.1016/j.tem.2017.10.004  0.311
2017 Nagar S, Trudler D, McKercher SR, Piña-Crespo J, Nakanishi N, Okamoto SI, Lipton SA. Molecular Pathway to Protection From Age-Dependent Photoreceptor Degeneration in Mef2 Deficiency. Investigative Ophthalmology & Visual Science. 58: 3741-3749. PMID 28738418 DOI: 10.1167/iovs.17-21767  0.696
2017 Nagar S, Noveral SM, Trudler D, Lopez KM, McKercher SR, Han X, Yates JR, Piña-Crespo JC, Nakanishi N, Satoh T, Okamoto SI, Lipton SA. MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. PMID 28461502 DOI: 10.1073/Pnas.1613067114  0.705
2016 Lipton SA, Rezaie T, Nutter A, Lopez KM, Parker J, Kosaka K, Satoh T, McKercher SR, Masliah E, Nakanishi N. Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer's disease models. Cell Death & Disease. 7: e2499. PMID 27906174 DOI: 10.1038/Cddis.2016.389  0.333
2016 Sunico CR, Sultan A, Nakamura T, Dolatabadi N, Parker J, Shan B, Han X, Yates JR, Masliah E, Ambasudhan R, Nakanishi N, Lipton SA. Role of sulfiredoxin as a peroxiredoxin-2 denitrosylase in human iPSC-derived dopaminergic neurons. Proceedings of the National Academy of Sciences of the United States of America. PMID 27821734 DOI: 10.1073/Pnas.1608784113  0.376
2016 Macrez R, Stys PK, Vivien D, Lipton SA, Docagne F. Mechanisms of glutamate toxicity in multiple sclerosis: biomarker and therapeutic opportunities. The Lancet. Neurology. 15: 1089-1102. PMID 27571160 DOI: 10.1016/S1474-4422(16)30165-X  0.368
2016 Sanz-Blasco S, Piña-Crespo JC, Zhang X, McKercher SR, Lipton SA. Levetiracetam inhibits oligomeric Aβ-induced glutamate release from human astrocytes. Neuroreport. PMID 27183239 DOI: 10.1097/Wnr.0000000000000601  0.723
2016 Jiang J, Chan A, Ali S, Saha A, Haushalter KJ, Lam WM, Glasheen M, Parker J, Brenner M, Mahon SB, Patel HH, Ambasudhan R, Lipton SA, Pilz RB, Boss GR. Hydrogen Sulfide-Mechanisms of Toxicity and Development of an Antidote. Scientific Reports. 6: 20831. PMID 26877209 DOI: 10.1038/Srep20831  0.316
2016 Takahashi H, Xia P, Cui J, Talantova M, Bodhinathan K, Li W, Saleem S, Holland EA, Tong G, Piña-Crespo J, Zhang D, Nakanishi N, Larrick JW, McKercher SR, Nakamura T, ... ... Lipton SA, et al. Corrigendum: Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease. Scientific Reports. 6: 20750. PMID 26867695 DOI: 10.1038/srep20750  0.759
2016 Akhtar MW, Sanz-Blasco S, Dolatabadi N, Parker J, Chon K, Lee MS, Soussou W, McKercher SR, Ambasudhan R, Nakamura T, Lipton SA. Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation. Nature Communications. 7: 10242. PMID 26743041 DOI: 10.1038/Ncomms10242  0.749
2016 Nakamura T, Lipton SA. Protein S-Nitrosylation as a Therapeutic Target for Neurodegenerative Diseases. Trends in Pharmacological Sciences. 37: 73-84. PMID 26707925 DOI: 10.1016/  0.339
2015 Chen S, Cui J, Jiang T, Olson ES, Cai QY, Yang M, Wu W, Guthrie JM, Robertson JD, Lipton SA, Ma L, Tsien RY, Gu Z. Gelatinase activity imaged by activatable cell-penetrating peptides in cell-based and in vivo models of stroke. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 26681768 DOI: 10.1177/0271678X15621573  0.315
2015 Takahashi H, Xia P, Cui J, Talantova M, Bodhinathan K, Li W, Holland EA, Tong G, Piña-Crespo J, Zhang D, Nakanishi N, Larrick JW, McKercher SR, Nakamura T, Wang Y, ... Lipton SA, et al. Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease. Scientific Reports. 5: 14781. PMID 26477507 DOI: 10.1038/srep14781  0.793
2015 Nakato R, Ohkubo Y, Konishi A, Shibata M, Kaneko Y, Iwawaki T, Nakamura T, Lipton SA, Uehara T. Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress. Scientific Reports. 5: 14812. PMID 26446798 DOI: 10.1038/srep14812  0.339
2015 Nakanishi N, Kang YJ, Tu S, McKercher SR, Masliah E, Lipton SA. Differential Effects of Pharmacologic and Genetic Modulation of NMDA Receptor Activity on HIV/gp120-Induced Neuronal Damage in an In Vivo Mouse Model. Journal of Molecular Neuroscience : Mn. PMID 26374431 DOI: 10.1007/S12031-015-0651-1  0.406
2015 Satoh T, Stalder R, McKercher SR, Williamson RE, Roth GP, Lipton SA. Nrf2 and HSF-1 Pathway Activation via Hydroquinone-Based Proelectrophilic Small Molecules is Regulated by Electrochemical Oxidation Potential. Asn Neuro. 7. PMID 26243592 DOI: 10.1177/1759091415593294  0.312
2015 Nakamura T, Lipton SA. Nitrosative Stress in the Nervous System: Guidelines for Designing Experimental Strategies to Study Protein S-Nitrosylation. Neurochemical Research. PMID 26118537 DOI: 10.1007/s11064-015-1640-z  0.303
2015 Yang B, Qu M, Wang R, Chatterton JE, Liu XB, Zhu B, Narisawa S, Millan JL, Nakanishi N, Swoboda K, Lipton SA, Zhang D. The critical role of membralin in postnatal motor neuron survival and disease. Elife. 4. PMID 25977983 DOI: 10.7554/eLife.06500  0.341
2015 Nakamura T, Prikhodko OA, Pirie E, Nagar S, Akhtar MW, Oh CK, McKercher SR, Ambasudhan R, Okamoto SI, Lipton SA. Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases. Neurobiology of Disease. PMID 25796565 DOI: 10.1016/j.nbd.2015.03.017  0.376
2015 Zhang D, Lee B, Nutter A, Song P, Dolatabadi N, Parker J, Sanz-Blasco S, Newmeyer T, Ambasudhan R, McKercher SR, Masliah E, Lipton SA. Protection from cyanide-induced brain injury by the Nrf2 transcriptional activator carnosic acid. Journal of Neurochemistry. 133: 898-908. PMID 25692407 DOI: 10.1111/Jnc.13074  0.374
2015 Okamoto SI, Lipton SA. S-Nitrosylation in neurogenesis and neuronal development. Biochimica Et Biophysica Acta. 1850: 1588-1593. PMID 25527866 DOI: 10.1016/j.bbagen.2014.12.013  0.316
2015 Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, ... ... Lipton SA, et al. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death and Differentiation. 22: 58-73. PMID 25236395 DOI: 10.1038/Cdd.2014.137  0.308
2014 Tu S, Okamoto S, Lipton SA, Xu H. Oligomeric Aβ-induced synaptic dysfunction in Alzheimer's disease. Molecular Neurodegeneration. 9: 48. PMID 25394486 DOI: 10.1186/1750-1326-9-48  0.385
2014 Choi MS, Nakamura T, Cho SJ, Han X, Holland EA, Qu J, Petsko GA, Yates JR, Liddington RC, Lipton SA. Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 15123-31. PMID 25378175 DOI: 10.1523/Jneurosci.4751-13.2014  0.362
2014 Okamoto S, Nakamura T, Cieplak P, Chan SF, Kalashnikova E, Liao L, Saleem S, Han X, Clemente A, Nutter A, Sances S, Brechtel C, Haus D, Haun F, Sanz-Blasco S, ... ... Lipton SA, et al. S-nitrosylation-mediated redox transcriptional switch modulates neurogenesis and neuronal cell death. Cell Reports. 8: 217-28. PMID 25001280 DOI: 10.1016/J.Celrep.2014.06.005  0.597
2014 Ambasudhan R, Dolatabadi N, Nutter A, Masliah E, Mckercher SR, Lipton SA. Potential for cell therapy in Parkinson's disease using genetically programmed human embryonic stem cell-derived neural progenitor cells. The Journal of Comparative Neurology. 522: 2845-56. PMID 24756727 DOI: 10.1002/Cne.23617  0.313
2014 Molokanova E, Akhtar MW, Sanz-Blasco S, Tu S, Piña-Crespo JC, McKercher SR, Lipton SA. Differential effects of synaptic and extrasynaptic NMDA receptors on Aβ-induced nitric oxide production in cerebrocortical neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 5023-8. PMID 24695719 DOI: 10.1523/Jneurosci.2907-13.2014  0.75
2014 Zhu S, Ambasudhan R, Sun W, Kim HJ, Talantova M, Wang X, Zhang M, Zhang Y, Laurent T, Parker J, Kim HS, Zaremba JD, Saleem S, Sanz-Blasco S, Masliah E, ... ... Lipton SA, et al. Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells. Cell Research. 24: 126-9. PMID 24296783 DOI: 10.1038/Cr.2013.156  0.538
2014 Jeon GS, Nakamura T, Lee JS, Choi WJ, Ahn SW, Lee KW, Sung JJ, Lipton SA. Potential effect of S-nitrosylated protein disulfide isomerase on mutant SOD1 aggregation and neuronal cell death in amyotrophic lateral sclerosis. Molecular Neurobiology. 49: 796-807. PMID 24091828 DOI: 10.1007/s12035-013-8562-z  0.376
2013 Ryan SD, Dolatabadi N, Chan SF, Zhang X, Akhtar MW, Parker J, Soldner F, Sunico CR, Nagar S, Talantova M, Lee B, Lopez K, Nutter A, Shan B, Molokanova E, ... ... Lipton SA, et al. Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription. Cell. 155: 1351-64. PMID 24290359 DOI: 10.1016/J.Cell.2013.11.009  0.592
2013 Nakanishi N, Ryan SD, Zhang X, Khan A, Holland T, Cho EG, Huang X, Liao FF, Xu H, Lipton SA, Tu S. Synaptic protein α1-takusan mitigates amyloid-β-induced synaptic loss via interaction with tau and postsynaptic density-95 at postsynaptic sites. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 14170-83. PMID 23986251 DOI: 10.1523/Jneurosci.4646-10.2013  0.59
2013 Sunico CR, Nakamura T, Rockenstein E, Mante M, Adame A, Chan SF, Newmeyer TF, Masliah E, Nakanishi N, Lipton SA. S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's disease. Molecular Neurodegeneration. 8: 29. PMID 23985028 DOI: 10.1186/1750-1326-8-29  0.312
2013 Marco S, Giralt A, Petrovic MM, Pouladi MA, Martínez-Turrillas R, Martínez-Hernández J, Kaltenbach LS, Torres-Peraza J, Graham RK, Watanabe M, Luján R, Nakanishi N, Lipton SA, Lo DC, Hayden MR, et al. Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models. Nature Medicine. 19: 1030-8. PMID 23852340 DOI: 10.1038/Nm.3246  0.41
2013 Talantova M, Sanz-Blasco S, Zhang X, Xia P, Akhtar MW, Okamoto S, Dziewczapolski G, Nakamura T, Cao G, Pratt AE, Kang YJ, Tu S, Molokanova E, McKercher SR, Hires SA, ... ... Lipton SA, et al. Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. Proceedings of the National Academy of Sciences of the United States of America. 110: E2518-27. PMID 23776240 DOI: 10.1073/Pnas.1306832110  0.74
2013 Nakamura T, Tu S, Akhtar MW, Sunico CR, Okamoto S, Lipton SA. Aberrant protein s-nitrosylation in neurodegenerative diseases. Neuron. 78: 596-614. PMID 23719160 DOI: 10.1016/j.neuron.2013.05.005  0.32
2013 Haun F, Nakamura T, Shiu AD, Cho DH, Tsunemi T, Holland EA, La Spada AR, Lipton SA. S-nitrosylation of dynamin-related protein 1 mediates mutant huntingtin-induced mitochondrial fragmentation and neuronal injury in Huntington's disease. Antioxidants & Redox Signaling. 19: 1173-84. PMID 23641925 DOI: 10.1089/ars.2012.4928  0.351
2013 Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, ... ... Lipton SA, et al. Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nature Medicine. 19: 473-80. PMID 23524343 DOI: 10.1038/Nm.3117  0.362
2013 Shi ZQ, Sunico CR, McKercher SR, Cui J, Feng GS, Nakamura T, Lipton SA. S-nitrosylated SHP-2 contributes to NMDA receptor-mediated excitotoxicity in acute ischemic stroke. Proceedings of the National Academy of Sciences of the United States of America. 110: 3137-42. PMID 23382182 DOI: 10.1073/Pnas.1215501110  0.416
2013 Ambasudhan R, Parker J, Ainza C, Dolatabadi N, Ryan S, Le T, Lipton SA, Haas RH. A human reprogrammed-cell model of MELAS Mitochondrion. 13: 943-944. DOI: 10.1016/j.mito.2013.07.112  0.548
2012 Piña-Crespo JC, Talantova M, Cho EG, Soussou W, Dolatabadi N, Ryan SD, Ambasudhan R, McKercher S, Deisseroth K, Lipton SA. High-frequency hippocampal oscillations activated by optogenetic stimulation of transplanted human ESC-derived neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15837-42. PMID 23136422 DOI: 10.1523/Jneurosci.3735-12.2012  0.769
2012 Rezaie T, McKercher SR, Kosaka K, Seki M, Wheeler L, Viswanath V, Chun T, Joshi R, Valencia M, Sasaki S, Tozawa T, Satoh T, Lipton SA. Protective effect of carnosic acid, a pro-electrophilic compound, in models of oxidative stress and light-induced retinal degeneration. Investigative Ophthalmology & Visual Science. 53: 7847-54. PMID 23081978 DOI: 10.1167/iovs.12-10793  0.302
2012 Akhtar MW, Sunico CR, Nakamura T, Lipton SA. Redox Regulation of Protein Function via Cysteine S-Nitrosylation and Its Relevance to Neurodegenerative Diseases. International Journal of Cell Biology. 2012: 463756. PMID 22956959 DOI: 10.1155/2012/463756  0.356
2012 Qu J, Nakamura T, Holland EA, McKercher SR, Lipton SA. S-nitrosylation of Cdk5: potential implications in amyloid-β-related neurotoxicity in Alzheimer disease. Prion. 6: 364-70. PMID 22874667 DOI: 10.4161/pri.21250  0.377
2012 Henson MA, Larsen RS, Lawson SN, Pérez-Otaño I, Nakanishi N, Lipton SA, Philpot BD. Genetic deletion of NR3A accelerates glutamatergic synapse maturation. Plos One. 7: e42327. PMID 22870318 DOI: 10.1371/Journal.Pone.0042327  0.372
2012 Nakamura T, Cho DH, Lipton SA. Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases. Experimental Neurology. 238: 12-21. PMID 22771760 DOI: 10.1016/j.expneurol.2012.06.032  0.387
2012 You H, Tsutsui S, Hameed S, Kannanayakal TJ, Chen L, Xia P, Engbers JD, Lipton SA, Stys PK, Zamponi GW. Aβ neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors. Proceedings of the National Academy of Sciences of the United States of America. 109: 1737-42. PMID 22307640 DOI: 10.1073/Pnas.1110789109  0.419
2011 Cho EG, Zaremba JD, McKercher SR, Talantova M, Tu S, Masliah E, Chan SF, Nakanishi N, Terskikh A, Lipton SA. MEF2C enhances dopaminergic neuron differentiation of human embryonic stem cells in a parkinsonian rat model. Plos One. 6: e24027. PMID 21901155 DOI: 10.1371/Journal.Pone.0024027  0.601
2011 Satoh T, Rezaie T, Seki M, Sunico CR, Tabuchi T, Kitagawa T, Yanagitai M, Senzaki M, Kosegawa C, Taira H, McKercher SR, Hoffman JK, Roth GP, Lipton SA. Dual neuroprotective pathways of a pro-electrophilic compound via HSF-1-activated heat-shock proteins and Nrf2-activated phase 2 antioxidant response enzymes. Journal of Neurochemistry. 119: 569-78. PMID 21883218 DOI: 10.1111/j.1471-4159.2011.07449.x  0.314
2011 Qu J, Nakamura T, Cao G, Holland EA, McKercher SR, Lipton SA. S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptide. Proceedings of the National Academy of Sciences of the United States of America. 108: 14330-5. PMID 21844361 DOI: 10.1073/pnas.1105172108  0.322
2011 Nakamura T, Lipton SA. Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics, and neuronal synaptic damage in neurodegenerative diseases. Cell Death and Differentiation. 18: 1478-86. PMID 21597461 DOI: 10.1038/cdd.2011.65  0.433
2011 Meng F, Yao D, Shi Y, Kabakoff J, Wu W, Reicher J, Ma Y, Moosmann B, Masliah E, Lipton SA, Gu Z. Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation. Molecular Neurodegeneration. 6: 34. PMID 21595948 DOI: 10.1186/1750-1326-6-34  0.325
2011 Kim J, Efe JA, Zhu S, Talantova M, Yuan X, Wang S, Lipton SA, Zhang K, Ding S. Direct reprogramming of mouse fibroblasts to neural progenitors. Proceedings of the National Academy of Sciences of the United States of America. 108: 7838-43. PMID 21521790 DOI: 10.1073/Pnas.1103113108  0.32
2011 Larsen RS, Corlew RJ, Henson MA, Roberts AC, Mishina M, Watanabe M, Lipton SA, Nakanishi N, Pérez-Otaño I, Weinberg RJ, Philpot BD. NR3A-containing NMDARs promote neurotransmitter release and spike timing-dependent plasticity. Nature Neuroscience. 14: 338-44. PMID 21297630 DOI: 10.1038/Nn.2750  0.347
2011 Krajewska M, Xu L, Xu W, Krajewski S, Kress CL, Cui J, Yang L, Irie F, Yamaguchi Y, Lipton SA, Reed JC. Endoplasmic reticulum protein BI-1 modulates unfolded protein response signaling and protects against stroke and traumatic brain injury. Brain Research. 1370: 227-37. PMID 21075086 DOI: 10.1016/j.brainres.2010.11.015  0.312
2011 Hardingham GE, Lipton SA. Regulation of neuronal oxidative and nitrosative stress by endogenous protective pathways and disease processes. Antioxidants & Redox Signaling. 14: 1421-4. PMID 20977364 DOI: 10.1089/Ars.2010.3573  0.37
2011 Nakamura T, Lipton SA. S-nitrosylation of critical protein thiols mediates protein misfolding and mitochondrial dysfunction in neurodegenerative diseases. Antioxidants & Redox Signaling. 14: 1479-92. PMID 20812868 DOI: 10.1089/ars.2010.3570  0.348
2010 Kwak YD, Ma T, Diao S, Zhang X, Chen Y, Hsu J, Lipton SA, Masliah E, Xu H, Liao FF. NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration. Molecular Neurodegeneration. 5: 49. PMID 21067594 DOI: 10.1186/1750-1326-5-49  0.346
2010 Piña-Crespo JC, Talantova M, Micu I, States B, Chen HS, Tu S, Nakanishi N, Tong G, Zhang D, Heinemann SF, Zamponi GW, Stys PK, Lipton SA. Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11501-5. PMID 20739572 DOI: 10.1523/Jneurosci.1593-10.2010  0.727
2010 Xia P, Chen HS, Zhang D, Lipton SA. Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11246-50. PMID 20720132 DOI: 10.1523/JNEUROSCI.2488-10.2010  0.43
2010 Xia K, Xiong H, Shin Y, Wang D, Deerinck T, Takahashi H, Ellisman MH, Lipton SA, Tong G, Descalzi G, Zhang D, Zhuo M, Zhang Z. Roles of KChIP1 in the regulation of GABA-mediated transmission and behavioral anxiety. Molecular Brain. 3: 23. PMID 20678225 DOI: 10.1186/1756-6606-3-23  0.356
2010 Nakamura T, Wang L, Wong CC, Scott FL, Eckelman BP, Han X, Tzitzilonis C, Meng F, Gu Z, Holland EA, Clemente AT, Okamoto S, Salvesen GS, Riek R, Yates JR, ... Lipton SA, et al. Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death. Molecular Cell. 39: 184-95. PMID 20670888 DOI: 10.1016/J.Molcel.2010.07.002  0.365
2010 Cho DH, Nakamura T, Lipton SA. Mitochondrial dynamics in cell death and neurodegeneration. Cellular and Molecular Life Sciences : Cmls. 67: 3435-47. PMID 20577776 DOI: 10.1007/s00018-010-0435-2  0.313
2010 Nakamura T, Cieplak P, Cho DH, Godzik A, Lipton SA. S-nitrosylation of Drp1 links excessive mitochondrial fission to neuronal injury in neurodegeneration. Mitochondrion. 10: 573-8. PMID 20447471 DOI: 10.1016/j.mito.2010.04.007  0.333
2010 Gu Z, Nakamura T, Lipton SA. Redox reactions induced by nitrosative stress mediate protein misfolding and mitochondrial dysfunction in neurodegenerative diseases. Molecular Neurobiology. 41: 55-72. PMID 20333559 DOI: 10.1007/S12035-010-8113-9  0.391
2010 Nakamura T, Lipton SA. Redox regulation of mitochondrial fission, protein misfolding, synaptic damage, and neuronal cell death: potential implications for Alzheimer's and Parkinson's diseases. Apoptosis : An International Journal On Programmed Cell Death. 15: 1354-63. PMID 20177970 DOI: 10.1007/s10495-010-0476-x  0.354
2010 Nakamura T, Lipton SA. Preventing Ca2+-mediated nitrosative stress in neurodegenerative diseases: possible pharmacological strategies. Cell Calcium. 47: 190-7. PMID 20060165 DOI: 10.1016/j.ceca.2009.12.009  0.386
2010 Zhao LC, Yang B, Wang R, Lipton SA, Zhang D. Type C botulinum toxin causes degeneration of motoneurons in vivo. Neuroreport. 21: 14-8. PMID 19907349 DOI: 10.1097/WNR.0b013e328330dcca  0.335
2010 Seki M, Soussou W, Manabe S, Lipton SA. Protection of retinal ganglion cells by caspase substrate-binding peptide IQACRG from N-methyl-D-aspartate receptor-mediated excitotoxicity. Investigative Ophthalmology & Visual Science. 51: 1198-207. PMID 19815732 DOI: 10.1167/Iovs.09-4102  0.733
2010 Sanz-Blasco S, Piña-Crespo J, Talantova M, Lipton S. P2-288: Abeta-mediated glutamate release from astrocytes Alzheimer's & Dementia. 6: S398-S398. DOI: 10.1016/J.Jalz.2010.05.1338  0.695
2009 Okamoto S, Pouladi MA, Talantova M, Yao D, Xia P, Ehrnhoefer DE, Zaidi R, Clemente A, Kaul M, Graham RK, Zhang D, Vincent Chen HS, Tong G, Hayden MR, Lipton SA. Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin. Nature Medicine. 15: 1407-13. PMID 19915593 DOI: 10.1038/Nm.2056  0.442
2009 Nakamura T, Lipton SA. According to GOSPEL: filling in the GAP(DH) of NO-mediated neurotoxicity. Neuron. 63: 3-6. PMID 19607786 DOI: 10.1016/j.neuron.2009.06.013  0.324
2009 Nakanishi N, Tu S, Shin Y, Cui J, Kurokawa T, Zhang D, Chen HS, Tong G, Lipton SA. Neuroprotection by the NR3A subunit of the NMDA receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 5260-5. PMID 19386922 DOI: 10.1523/JNEUROSCI.1067-09.2009  0.409
2009 Cho DH, Nakamura T, Fang J, Cieplak P, Godzik A, Gu Z, Lipton SA. S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science (New York, N.Y.). 324: 102-5. PMID 19342591 DOI: 10.1126/Science.1171091  0.368
2009 Bajpai R, Coppola G, Kaul M, Talantova M, Cimadamore F, Nilbratt M, Geschwind DH, Lipton SA, Terskikh AV. Molecular stages of rapid and uniform neuralization of human embryonic stem cells. Cell Death and Differentiation. 16: 807-25. PMID 19282867 DOI: 10.1038/Cdd.2009.18  0.301
2009 Lipton SA, Li H, Zaremba JD, McKercher SR, Cui J, Kang YJ, Nie Z, Soussou W, Talantova M, Okamoto S, Nakanishi N. Autistic phenotype from MEF2C knockout cells. Science (New York, N.Y.). 323: 208. PMID 19131610 DOI: 10.1126/Science.323.5911.208B  0.748
2009 Nakamura T, Lipton SA. Cell death: protein misfolding and neurodegenerative diseases. Apoptosis : An International Journal On Programmed Cell Death. 14: 455-68. PMID 19130231 DOI: 10.1007/s10495-008-0301-y  0.346
2008 Seki M, Lipton SA. Targeting excitotoxic/free radical signaling pathways for therapeutic intervention in glaucoma. Progress in Brain Research. 173: 495-510. PMID 18929130 DOI: 10.1016/S0079-6123(08)01134-5  0.417
2008 Li H, Radford JC, Ragusa MJ, Shea KL, McKercher SR, Zaremba JD, Soussou W, Nie Z, Kang YJ, Nakanishi N, Okamoto S, Roberts AJ, Schwarz JJ, Lipton SA. Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. Proceedings of the National Academy of Sciences of the United States of America. 105: 9397-402. PMID 18599437 DOI: 10.1073/Pnas.0802876105  0.775
2008 Li Z, McKercher SR, Cui J, Nie Z, Soussou W, Roberts AJ, Sallmen T, Lipton JH, Talantova M, Okamoto S, Lipton SA. Myocyte enhancer factor 2C as a neurogenic and antiapoptotic transcription factor in murine embryonic stem cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6557-68. PMID 18579729 DOI: 10.1523/Jneurosci.0134-08.2008  0.746
2008 Lipton SA. NMDA receptor activity regulates transcription of antioxidant pathways. Nature Neuroscience. 11: 381-2. PMID 18368041 DOI: 10.1038/nn0408-381  0.408
2008 Tong G, Takahashi H, Tu S, Shin Y, Talantova M, Zago W, Xia P, Nie Z, Goetz T, Zhang D, Lipton SA, Nakanishi N. Modulation of NMDA receptor properties and synaptic transmission by the NR3A subunit in mouse hippocampal and cerebrocortical neurons. Journal of Neurophysiology. 99: 122-32. PMID 18003876 DOI: 10.1152/jn.01044.2006  0.624
2008 Satoh T, Kosaka K, Itoh K, Kobayashi A, Yamamoto M, Shimojo Y, Kitajima C, Cui J, Kamins J, Okamoto S, Izumi M, Shirasawa T, Lipton SA. Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1. Journal of Neurochemistry. 104: 1116-31. PMID 17995931 DOI: 10.1111/J.1471-4159.2007.05039.X  0.351
2008 Nakagomi S, Barsoum MJ, Bossy-Wetzel E, Sütterlin C, Malhotra V, Lipton SA. A Golgi fragmentation pathway in neurodegeneration. Neurobiology of Disease. 29: 221-31. PMID 17964175 DOI: 10.1016/J.Nbd.2007.08.015  0.349
2008 Nakamura T, Lipton SA. Emerging roles of S-nitrosylation in protein misfolding and neurodegenerative diseases. Antioxidants & Redox Signaling. 10: 87-101. PMID 17961071 DOI: 10.1089/ars.2007.1858  0.404
2007 Fang J, Nakamura T, Cho DH, Gu Z, Lipton SA. S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 104: 18742-7. PMID 18003920 DOI: 10.1073/Pnas.0705904104  0.33
2007 Stys PK, Lipton SA. White matter NMDA receptors: an unexpected new therapeutic target? Trends in Pharmacological Sciences. 28: 561-6. PMID 17961731 DOI: 10.1016/J.Tips.2007.10.003  0.341
2007 Alirezaei M, Watry DD, Flynn CF, Kiosses WB, Masliah E, Williams BR, Kaul M, Lipton SA, Fox HS. Human immunodeficiency virus-1/surface glycoprotein 120 induces apoptosis through RNA-activated protein kinase signaling in neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 11047-55. PMID 17928446 DOI: 10.1523/Jneurosci.2733-07.2007  0.378
2007 Lipton SA. Pathologically activated therapeutics for neuroprotection. Nature Reviews. Neuroscience. 8: 803-8. PMID 17882256 DOI: 10.1038/nrn2229  0.36
2007 Lipton SA, Gu Z, Nakamura T. Inflammatory mediators leading to protein misfolding and uncompetitive/fast off-rate drug therapy for neurodegenerative disorders. International Review of Neurobiology. 82: 1-27. PMID 17678953 DOI: 10.1016/S0074-7742(07)82001-0  0.447
2007 Redmond DE, Bjugstad KB, Teng YD, Ourednik V, Ourednik J, Wakeman DR, Parsons XH, Gonzalez R, Blanchard BC, Kim SU, Gu Z, Lipton SA, Markakis EA, Roth RH, Elsworth JD, et al. Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 12175-80. PMID 17586681 DOI: 10.1073/Pnas.0704091104  0.315
2007 Lipton SA. Pathologically-activated therapeutics for neuroprotection: mechanism of NMDA receptor block by memantine and S-nitrosylation. Current Drug Targets. 8: 621-32. PMID 17504105 DOI: 10.2174/138945007780618472  0.424
2007 Nakamura T, Lipton SA. S-Nitrosylation and uncompetitive/fast off-rate (UFO) drug therapy in neurodegenerative disorders of protein misfolding. Cell Death and Differentiation. 14: 1305-14. PMID 17431424 DOI: 10.1038/sj.cdd.4402138  0.41
2007 Nakamura T, Gu Z, Lipton SA. Contribution of glutamatergic signaling to nitrosative stress-induced protein misfolding in normal brain aging and neurodegenerative diseases. Aging Cell. 6: 351-9. PMID 17388798 DOI: 10.1111/J.1474-9726.2007.00284.X  0.309
2007 Lee JP, Jeyakumar M, Gonzalez R, Takahashi H, Lee PJ, Baek RC, Clark D, Rose H, Fu G, Clarke J, McKercher S, Meerloo J, Muller FJ, Park KI, Butters TD, ... ... Lipton SA, et al. Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease. Nature Medicine. 13: 439-47. PMID 17351625 DOI: 10.1038/Nm1548  0.354
2007 Berliocchi L, Corasaniti MT, Bagetta G, Lipton SA. Neuroinflammation in neuronal degeneration and repair. Cell Death and Differentiation. 14: 883-4. PMID 17256010 DOI: 10.1038/sj.cdd.4402097  0.309
2007 Choi WT, Kaul M, Kumar S, Wang J, Kumar IM, Dong CZ, An J, Lipton SA, Huang Z. Neuronal apoptotic signaling pathways probed and intervened by synthetically and modularly modified (SMM) chemokines. The Journal of Biological Chemistry. 282: 7154-63. PMID 17218311 DOI: 10.1074/Jbc.M611599200  0.378
2007 Takahashi H, Shin Y, Cho SJ, Zago WM, Nakamura T, Gu Z, Ma Y, Furukawa H, Liddington R, Zhang D, Tong G, Chen HS, Lipton SA. Hypoxia enhances S-nitrosylation-mediated NMDA receptor inhibition via a thiol oxygen sensor motif. Neuron. 53: 53-64. PMID 17196530 DOI: 10.1016/J.Neuron.2006.11.023  0.309
2007 Satoh T, Lipton SA. Redox regulation of neuronal survival mediated by electrophilic compounds. Trends in Neurosciences. 30: 37-45. PMID 17137643 DOI: 10.1016/j.tins.2006.11.004  0.304
2007 Yuan H, Gerencser AA, Liot G, Lipton SA, Ellisman M, Perkins GA, Bossy-Wetzel E. Mitochondrial fission is an upstream and required event for bax foci formation in response to nitric oxide in cortical neurons. Cell Death and Differentiation. 14: 462-71. PMID 17053808 DOI: 10.1038/Sj.Cdd.4402046  0.311
2007 Awobuluyi M, Yang J, Ye Y, Chatterton JE, Godzik A, Lipton SA, Zhang D. Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-D-aspartate receptors. Molecular Pharmacology. 71: 112-22. PMID 17047094 DOI: 10.1124/mol.106.030700  0.347
2007 Kaul M, Ma Q, Medders KE, Desai MK, Lipton SA. HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection. Cell Death and Differentiation. 14: 296-305. PMID 16841089 DOI: 10.1038/Sj.Cdd.4402006  0.368
2006 Kaul M, Lipton SA. Mechanisms of neuroimmunity and neurodegeneration associated with HIV-1 infection and AIDS. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 1: 138-51. PMID 18040780 DOI: 10.1007/S11481-006-9011-9  0.318
2006 Wada A, Takahashi H, Lipton SA, Chen HS. NR3A modulates the outer vestibule of the "NMDA" receptor channel. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 13156-66. PMID 17182766 DOI: 10.1523/JNEUROSCI.2552-06.2006  0.31
2006 Barsoum MJ, Yuan H, Gerencser AA, Liot G, Kushnareva Y, Gräber S, Kovacs I, Lee WD, Waggoner J, Cui J, White AD, Bossy B, Martinou JC, Youle RJ, Lipton SA, et al. Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. The Embo Journal. 25: 3900-11. PMID 16874299 DOI: 10.1038/Sj.Emboj.7601253  0.354
2006 Wang Y, Eu J, Washburn M, Gong T, Chen HS, James WL, Lipton SA, Stamler JS, Went GT, Porter S. The pharmacology of aminoadamantane nitrates. Current Alzheimer Research. 3: 201-4. PMID 16842096 DOI: 10.2174/156720506777632808  0.373
2006 Kaul M, Lipton SA. Mechanisms of neuronal injury and death in HIV-1 associated dementia. Current Hiv Research. 4: 307-18. PMID 16842083 DOI: 10.2174/157016206777709384  0.331
2006 Chen HS, Lipton SA. The chemical biology of clinically tolerated NMDA receptor antagonists. Journal of Neurochemistry. 97: 1611-26. PMID 16805772 DOI: 10.1111/j.1471-4159.2006.03991.x  0.426
2006 Uehara T, Nakamura T, Yao D, Shi ZQ, Gu Z, Ma Y, Masliah E, Nomura Y, Lipton SA. S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. Nature. 441: 513-7. PMID 16724068 DOI: 10.1038/Nature04782  0.327
2006 Lipton SA. NMDA receptors, glial cells, and clinical medicine. Neuron. 50: 9-11. PMID 16600850 DOI: 10.1016/j.neuron.2006.03.026  0.379
2006 Lipton SA. Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond. Nature Reviews. Drug Discovery. 5: 160-70. PMID 16424917 DOI: 10.1038/nrd1958  0.381
2006 Satoh T, Okamoto SI, Cui J, Watanabe Y, Furuta K, Suzuki M, Tohyama K, Lipton SA. Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophilic [correction of electrophillic] phase II inducers. Proceedings of the National Academy of Sciences of the United States of America. 103: 768-73. PMID 16407140 DOI: 10.1073/pnas.0505723102  0.374
2005 Han P, Dou F, Li F, Zhang X, Zhang YW, Zheng H, Lipton SA, Xu H, Liao FF. Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11542-52. PMID 16354912 DOI: 10.1523/Jneurosci.3831-05.2005  0.366
2005 Manabe S, Gu Z, Lipton SA. Activation of matrix metalloproteinase-9 via neuronal nitric oxide synthase contributes to NMDA-induced retinal ganglion cell death. Investigative Ophthalmology & Visual Science. 46: 4747-53. PMID 16303975 DOI: 10.1167/Iovs.05-0128  0.406
2005 Kaul M, Lipton SA. Experimental and potential future therapeutic approaches for HIV-1 associated dementia targeting receptors for chemokines, glutamate and erythropoietin. Neurotoxicity Research. 8: 167-86. PMID 16260394 DOI: 10.1007/Bf03033828  0.359
2005 Gu Z, Cui J, Brown S, Fridman R, Mobashery S, Strongin AY, Lipton SA. A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 6401-8. PMID 16000631 DOI: 10.1523/Jneurosci.1563-05.2005  0.302
2005 Lipton SA. The molecular basis of memantine action in Alzheimer's disease and other neurologic disorders: low-affinity, uncompetitive antagonism. Current Alzheimer Research. 2: 155-65. PMID 15974913 DOI: 10.2174/1567205053585846  0.421
2005 Chen HS, Lipton SA. Pharmacological implications of two distinct mechanisms of interaction of memantine with N-methyl-D-aspartate-gated channels. The Journal of Pharmacology and Experimental Therapeutics. 314: 961-71. PMID 15901795 DOI: 10.1124/jpet.105.085142  0.308
2005 Brody SA, Nakanishi N, Tu S, Lipton SA, Geyer MA. A developmental influence of the N-methyl-D-aspartate receptor NR3A subunit on prepulse inhibition of startle. Biological Psychiatry. 57: 1147-52. PMID 15866554 DOI: 10.1016/J.Biopsych.2005.01.024  0.37
2005 Kaul M, Zheng J, Okamoto S, Gendelman HE, Lipton SA. HIV-1 infection and AIDS: consequences for the central nervous system. Cell Death and Differentiation. 12: 878-92. PMID 15832177 DOI: 10.1038/Sj.Cdd.4401623  0.344
2004 Lipton SA. Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults. Neurorx : the Journal of the American Society For Experimental Neurotherapeutics. 1: 101-10. PMID 15717010 DOI: 10.1602/neurorx.1.1.101  0.421
2004 Lipton SA. Paradigm shift in NMDA receptor antagonist drug development: molecular mechanism of uncompetitive inhibition by memantine in the treatment of Alzheimer's disease and other neurologic disorders. Journal of Alzheimer's Disease : Jad. 6: S61-74. PMID 15665416 DOI: 10.3233/Jad-2004-6S610  0.422
2004 Chae HJ, Kim HR, Xu C, Bailly-Maitre B, Krajewska M, Krajewski S, Banares S, Cui J, Digicaylioglu M, Ke N, Kitada S, Monosov E, Thomas M, Kress CL, Babendure JR, ... ... Lipton SA, et al. BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress. Molecular Cell. 15: 355-66. PMID 15304216 DOI: 10.1016/J.Molcel.2004.06.038  0.311
2004 Yao D, Gu Z, Nakamura T, Shi ZQ, Ma Y, Gaston B, Palmer LA, Rockenstein EM, Zhang Z, Masliah E, Uehara T, Lipton SA. Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity. Proceedings of the National Academy of Sciences of the United States of America. 101: 10810-4. PMID 15252205 DOI: 10.1073/Pnas.0404161101  0.331
2004 Digicaylioglu M, Garden G, Timberlake S, Fletcher L, Lipton SA. Acute neuroprotective synergy of erythropoietin and insulin-like growth factor I. Proceedings of the National Academy of Sciences of the United States of America. 101: 9855-60. PMID 15210945 DOI: 10.1073/pnas.0403172101  0.628
2004 Digicaylioglu M, Kaul M, Fletcher L, Dowen R, Lipton SA. Erythropoietin protects cerebrocortical neurons from HIV-1/gp120-induced damage. Neuroreport. 15: 761-3. PMID 15073510 DOI: 10.1097/00001756-200404090-00004  0.325
2004 Kaul M, Lipton SA. Signaling pathways to neuronal damage and apoptosis in human immunodeficiency virus type 1-associated dementia: Chemokine receptors, excitotoxicity, and beyond. Journal of Neurovirology. 10: 97-101. PMID 14982746 DOI: 10.1080/753312759  0.375
2004 Bossy-Wetzel E, Talantova MV, Lee WD, Schölzke MN, Harrop A, Mathews E, Götz T, Han J, Ellisman MH, Perkins GA, Lipton SA. Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels. Neuron. 41: 351-65. PMID 14766175 DOI: 10.1016/S0896-6273(04)00015-7  0.369
2004 Lipton SA, Chen HS. Paradigm shift in neuroprotective drug development: clinically tolerated NMDA receptor inhibition by memantine. Cell Death and Differentiation. 11: 18-20. PMID 14647237 DOI: 10.1038/sj.cdd.4401344  0.338
2003 Kermer P, Digicaylioglu MH, Kaul M, Zapata JM, Krajewska M, Stenner-Liewen F, Takayama S, Krajewski S, Lipton SA, Reed JC. BAG1 over-expression in brain protects against stroke. Brain Pathology (Zurich, Switzerland). 13: 495-506. PMID 14655755 DOI: 10.1111/J.1750-3639.2003.Tb00480.X  0.366
2003 Cui J, Ma YP, Lipton SA, Pan ZH. Glycine receptors and glycinergic synaptic input at the axon terminals of mammalian retinal rod bipolar cells. The Journal of Physiology. 553: 895-909. PMID 14514876 DOI: 10.1113/jphysiol.2003.052092  0.307
2003 Sucher NJ, Kohler K, Tenneti L, Wong HK, Gründer T, Fauser S, Wheeler-Schilling T, Nakanishi N, Lipton SA, Guenther E. N-methyl-D-aspartate receptor subunit NR3A in the retina: developmental expression, cellular localization, and functional aspects. Investigative Ophthalmology & Visual Science. 44: 4451-6. PMID 14507892 DOI: 10.1167/iovs.02-1259  0.391
2003 Lipton SA. Possible role for memantine in protecting retinal ganglion cells from glaucomatous damage. Survey of Ophthalmology. 48: S38-46. PMID 12852433 DOI: 10.1016/S0039-6257(03)00008-0  0.432
2003 Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS. GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2. The Journal of Biological Chemistry. 278: 34641-53. PMID 12819203 DOI: 10.1074/Jbc.M304594200  0.307
2003 Manabe S, Lipton SA. Divergent NMDA signals leading to proapoptotic and antiapoptotic pathways in the rat retina. Investigative Ophthalmology & Visual Science. 44: 385-92. PMID 12506100 DOI: 10.1167/iovs.02-0187  0.361
2002 Okamoto S, Sherman K, Bai G, Lipton SA. Effect of the ubiquitous transcription factors, SP1 and MAZ, on NMDA receptor subunit type 1 (NR1) expression during neuronal differentiation. Brain Research. Molecular Brain Research. 107: 89-96. PMID 12425938 DOI: 10.1016/S0169-328X(02)00440-0  0.388
2002 Wong HK, Liu XB, Matos MF, Chan SF, Pérez-Otaño I, Boysen M, Cui J, Nakanishi N, Trimmer JS, Jones EG, Lipton SA, Sucher NJ. Temporal and regional expression of NMDA receptor subunit NR3A in the mammalian brain. The Journal of Comparative Neurology. 450: 303-17. PMID 12209845 DOI: 10.1002/cne.10314  0.35
2002 Gu Z, Kaul M, Yan B, Kridel SJ, Cui J, Strongin A, Smith JW, Liddington RC, Lipton SA. S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death. Science (New York, N.Y.). 297: 1186-90. PMID 12183632 DOI: 10.1126/Science.1073634  0.317
2002 Lipton SA, Choi YB, Takahashi H, Zhang D, Li W, Godzik A, Bankston LA. Cysteine regulation of protein function--as exemplified by NMDA-receptor modulation. Trends in Neurosciences. 25: 474-80. PMID 12183209 DOI: 10.1016/S0166-2236(02)02245-2  0.302
2002 Garden GA, Budd SL, Tsai E, Hanson L, Kaul M, D'Emilia DM, Friedlander RM, Yuan J, Masliah E, Lipton SA. Caspase cascades in human immunodeficiency virus-associated neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 4015-24. PMID 12019321 DOI: 10.1523/Jneurosci.22-10-04015.2002  0.656
2002 Sasaki YF, Rothe T, Premkumar LS, Das S, Cui J, Talantova MV, Wong HK, Gong X, Chan SF, Zhang D, Nakanishi N, Sucher NJ, Lipton SA. Characterization and comparison of the NR3A subunit of the NMDA receptor in recombinant systems and primary cortical neurons. Journal of Neurophysiology. 87: 2052-63. PMID 11929923 DOI: 10.1152/jn.00531.2001  0.395
2002 Okamoto S, Li Z, Ju C, Scholzke MN, Mathews E, Cui J, Salvesen GS, Bossy-Wetzel E, Lipton SA. Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 99: 3974-9. PMID 11904443 DOI: 10.1073/Pnas.022036399  0.402
2002 Chatterton JE, Awobuluyi M, Premkumar LS, Takahashi H, Talantova M, Shin Y, Cui J, Tu S, Sevarino KA, Nakanishi N, Tong G, Lipton SA, Zhang D. Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits. Nature. 415: 793-8. PMID 11823786 DOI: 10.1038/nature715  0.411
2001 Le DA, Lipton SA. Potential and current use of N-methyl-D-aspartate (NMDA) receptor antagonists in diseases of aging. Drugs & Aging. 18: 717-24. PMID 11735619 DOI: 10.2165/00002512-200118100-00001  0.372
2001 Digicaylioglu M, Lipton SA. Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades. Nature. 412: 641-7. PMID 11493922 DOI: 10.1038/35088074  0.378
2001 Kaul M, Garden GA, Lipton SA. Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature. 410: 988-94. PMID 11309629 DOI: 10.1038/35073667  0.661
2001 Zhang D, Pan ZH, Awobuluyi M, Lipton SA. Structure and function of GABA(C) receptors: a comparison of native versus recombinant receptors. Trends in Pharmacological Sciences. 22: 121-32. PMID 11239575 DOI: 10.1016/S0165-6147(00)01625-4  0.305
2001 Choi Y, Chen HV, Lipton SA. Three pairs of cysteine residues mediate both redox and zn2+ modulation of the nmda receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 392-400. PMID 11160420 DOI: 10.1523/Jneurosci.21-02-00392.2001  0.355
2001 Perez-Otano I, Schulteis CT, Contractor A, Lipton SA, Trimmer JS, Sucher NJ, Heinemann SF. Assembly with the NR1 subunit is required for surface expression of NR3A-containing NMDA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 1228-37. PMID 11160393 DOI: 10.1523/Jneurosci.21-04-01228.2001  0.332
2001 Traynelis SF, Lipton SA. Is tissue plasminogen activator a threat to neurons? Nature Medicine. 7: 17-8. PMID 11135603 DOI: 10.1038/83289  0.306
2001 Lipton S. NO and regulation of NMDA receptor function European Neuropsychopharmacology. 11: S176-S177. DOI: 10.1016/S0924-977X(01)80115-2  0.344
2000 Choi YB, Lipton SA. Redox modulation of the NMDA receptor. Cellular and Molecular Life Sciences : Cmls. 57: 1535-41. PMID 11092448 DOI: 10.1007/Pl00000638  0.379
2000 Kikuchi M, Tenneti L, Lipton SA. Role of p38 mitogen-activated protein kinase in axotomy-induced apoptosis of rat retinal ganglion cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 5037-44. PMID 10864961 DOI: 10.1523/Jneurosci.20-13-05037.2000  0.334
2000 Okamoto S, Krainc D, Sherman K, Lipton SA. Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation. Proceedings of the National Academy of Sciences of the United States of America. 97: 7561-6. PMID 10852968 DOI: 10.1073/Pnas.130502697  0.372
2000 Budd SL, Tenneti L, Lishnak T, Lipton SA. Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons. Proceedings of the National Academy of Sciences of the United States of America. 97: 6161-6. PMID 10811898 DOI: 10.1073/pnas.100121097  0.388
2000 Yeh MW, Kaul M, Zheng J, Nottet HS, Thylin M, Gendelman HE, Lipton SA. Cytokine-stimulated, but not HIV-infected, human monocyte-derived macrophages produce neurotoxic levels of l -cysteine. Journal of Immunology (Baltimore, Md. : 1950). 164: 4265-70. PMID 10754324 DOI: 10.4049/Jimmunol.164.8.4265  0.31
2000 Tenneti L, Lipton SA. Involvement of activated caspase-3-like proteases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neurons. Journal of Neurochemistry. 74: 134-42. PMID 10617114 DOI: 10.1046/j.1471-4159.2000.0740134.x  0.392
2000 Choi YB, Tenneti L, Le DA, Ortiz J, Bai G, Chen HS, Lipton SA. Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation. Nature Neuroscience. 3: 15-21. PMID 10607390 DOI: 10.1038/71090  0.329
1999 Budd SL, Lipton SA. Signaling events in NMDA receptor-induced apoptosis in cerebrocortical cultures. Annals of the New York Academy of Sciences. 893: 261-4. PMID 10672244 DOI: 10.1111/J.1749-6632.1999.Tb07832.X  0.337
1999 Okamoto S, Sherman K, Lipton SA. Absence of binding activity of neuron-restrictive silencer factor is necessary, but not sufficient for transcription of NMDA receptor subunit type 1 in neuronal cells. Brain Research. Molecular Brain Research. 74: 44-54. PMID 10640675 DOI: 10.1016/S0169-328X(99)00250-8  0.394
1999 Kim WK, Choi YB, Rayudu PV, Das P, Asaad W, Arnelle DR, Stamler JS, Lipton SA. Attenuation of NMDA receptor activity and neurotoxicity by nitroxyl anion, NO-. Neuron. 24: 461-9. PMID 10571239 DOI: 10.1016/S0896-6273(00)80859-4  0.395
1999 Lipton SA. Neuronal protection and destruction by NO. Cell Death and Differentiation. 6: 943-51. PMID 10556970 DOI: 10.1038/sj.cdd.4400580  0.399
1999 Stieg PE, Sathi S, Warach S, Le DA, Lipton SA. Neuroprotection by the NMDA receptor-associated open-channel blocker memantine in a photothrombotic model of cerebral focal ischemia in neonatal rat. European Journal of Pharmacology. 375: 115-20. PMID 10443569 DOI: 10.1016/S0014-2999(99)00214-9  0.399
1999 Choi YB, Lipton SA. Identification and mechanism of action of two histidine residues underlying high-affinity Zn2+ inhibition of the NMDA receptor. Neuron. 23: 171-80. PMID 10402203 DOI: 10.1016/S0896-6273(00)80763-1  0.345
1999 Kaul M, Lipton SA. Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 96: 8212-6. PMID 10393974 DOI: 10.1073/pnas.96.14.8212  0.387
1999 Nicotera P, Lipton SA. Excitotoxins in neuronal apoptosis and necrosis. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 19: 583-91. PMID 10366188 DOI: 10.1097/00004647-199906000-00001  0.36
1999 D'Emilia DM, Lipton SA. Ratio of S-nitrosohomocyst(e)ine to homocyst(e)ine or other thiols determines neurotoxicity in rat cerebrocortical cultures. Neuroscience Letters. 265: 103-6. PMID 10327179 DOI: 10.1016/S0304-3940(99)00210-4  0.346
1999 Lipton SA. Redox sensitivity of NMDA receptors. Methods in Molecular Biology (Clifton, N.J.). 128: 121-30. PMID 10320978 DOI: 10.1385/1-59259-683-5:121  0.343
1999 Lipton SA, Nakanishi N. Shakespeare in love--with NMDA receptors? Nature Medicine. 5: 270-1. PMID 10086378 DOI: 10.1038/6481  0.422
1998 Budd SL, Lipton SA. Calcium tsunamis: do astrocytes transmit cell death messages via gap junctions during ischemia? Nature Neuroscience. 1: 431-2. PMID 10196536 DOI: 10.1038/2147  0.302
1998 Krainc D, Bai G, Okamoto S, Carles M, Kusiak JW, Brent RN, Lipton SA. Synergistic activation of the N-methyl-D-aspartate receptor subunit 1 promoter by myocyte enhancer factor 2C and Sp1. The Journal of Biological Chemistry. 273: 26218-24. PMID 9748305 DOI: 10.1074/Jbc.273.40.26218  0.398
1998 Tenneti L, D'Emilia DM, Troy CM, Lipton SA. Role of caspases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neurons. Journal of Neurochemistry. 71: 946-59. PMID 9721720 DOI: 10.1046/j.1471-4159.1998.71030946.x  0.395
1998 Lipton SA, Choi YB, Sucher NJ, Chen HS. Neuroprotective versus neurodestructive effects of NO-related species. Biofactors (Oxford, England). 8: 33-40. PMID 9699006 DOI: 10.1002/Biof.5520080107  0.396
1998 Chen HS, Wang YF, Rayudu PV, Edgecomb P, Neill JC, Segal MM, Lipton SA, Jensen FE. Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation. Neuroscience. 86: 1121-32. PMID 9697119 DOI: 10.1016/S0306-4522(98)00163-8  0.579
1998 Zurakowski D, Vorwerk CK, Gorla M, Kanellopoulos AJ, Chaturvedi N, Grosskreutz CL, Lipton SA, Dreyer EB. Nitrate therapy may retard glaucomatous optic neuropathy, perhaps through modulation of glutamate receptors. Vision Research. 38: 1489-94. PMID 9667013 DOI: 10.1016/S0042-6989(98)00003-0  0.352
1998 Das S, Sasaki YF, Rothe T, Premkumar LS, Takasu M, Crandall JE, Dikkes P, Conner DA, Rayudu PV, Cheung W, Chen HS, Lipton SA, Nakanishi N. Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. Nature. 393: 377-81. PMID 9620802 DOI: 10.1038/30748  0.386
1998 Lipton SA, Nicotera P. Calcium, free radicals and excitotoxins in neuronal apoptosis. Cell Calcium. 23: 165-71. PMID 9601612 DOI: 10.1016/S0143-4160(98)90115-4  0.336
1998 Lipton SA. Neuronal injury associated with HIV-1: approaches to treatment. Annual Review of Pharmacology and Toxicology. 38: 159-77. PMID 9597152 DOI: 10.1146/annurev.pharmtox.38.1.159  0.388
1998 Soriano SG, Wang YF, Lipton SA, Dikkes P, Gutierrez-Ramos JC, Hickey PR. ICAM-1 dependent pathway is not involved in the development of neuronal apoptosis after transient focal cerebral ischemia. Brain Research. 780: 337-41. PMID 9507184 DOI: 10.1016/S0006-8993(97)01298-5  0.334
1998 Lipton SA, Nicotera P. Excitotoxicity, free radicals, necrosis, and apoptosis Neuroscientist. 4: 345-352. DOI: 10.1177/107385849800400516  0.388
1997 Le D, Das S, Wang YF, Yoshizawa T, Sasaki YF, Takasu M, Nemes A, Mendelsohn M, Dikkes P, Lipton SA, Nakanishi N. Enhanced neuronal death from focal ischemia in AMPA-receptor transgenic mice. Brain Research. Molecular Brain Research. 52: 235-41. PMID 9495544 DOI: 10.1016/S0169-328X(97)00261-1  0.42
1997 Sucher NJ, Lipton SA, Dreyer EB. Molecular basis of glutamate toxicity in retinal ganglion cells. Vision Research. 37: 3483-93. PMID 9425525 DOI: 10.1016/S0042-6989(97)00047-3  0.401
1997 Tenneti L, D'Emilia DM, Lipton SA. Suppression of neuronal apoptosis by S-nitrosylation of caspases. Neuroscience Letters. 236: 139-42. PMID 9406756 DOI: 10.1016/S0304-3940(97)00780-5  0.341
1997 Lipton SA. Neuropathogenesis of acquired immunodeficiency syndrome dementia. Current Opinion in Neurology. 10: 247-53. PMID 9229134 DOI: 10.1097/00019052-199706000-00014  0.33
1997 Lipton SA, Kim WK, Choi YB, Kumar S, D'Emilia DM, Rayudu PV, Arnelle DR, Stamler JS. Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor. Proceedings of the National Academy of Sciences of the United States of America. 94: 5923-8. PMID 9159176 DOI: 10.1073/Pnas.94.11.5923  0.374
1997 Chen HS, Lipton SA. Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism. The Journal of Physiology. 499: 27-46. PMID 9061638 DOI: 10.1113/Jphysiol.1997.Sp021909  0.328
1997 Lipton SA. Janus faces of NF-kappa B: neurodestruction versus neuroprotection. Nature Medicine. 3: 20-2. PMID 8986730 DOI: 10.1038/nm0197-20  0.303
1997 Lipton SA. AIDS dementia as a form of excitotoxicity: potential therapy with NMDA open-channel blockers and redox congeners of nitric oxide Electroencephalography and Clinical Neurophysiology. 102: P2. DOI: 10.1016/S0013-4694(97)86208-6  0.408
1997 Lipton SA. 60 – NO-Related Species: Neuroprotection versus Neurodestruction Primer On Cerebrovascular Diseases. 210-213. DOI: 10.1016/B978-012743170-3.50061-3  0.373
1996 Bonfoco E, Zhivotovsky B, Rossi AD, Aguilar-Santelises M, Orrenius S, Lipton SA, Nicotera P. BCL-2 delay apoptosis and PARP cleavage induced by NO donors in GT1-7 cells. Neuroreport. 8: 273-6. PMID 9051794 DOI: 10.1097/00001756-199612200-00054  0.328
1996 Pan ZH, Segal MM, Lipton SA. Nitric oxide-related species inhibit evoked neurotransmission but enhance spontaneous miniature synaptic currents in central neuronal cultures. Proceedings of the National Academy of Sciences of the United States of America. 93: 15423-8. PMID 8986827 DOI: 10.1073/Pnas.93.26.15423  0.573
1996 Sucher NJ, Awobuluyi M, Choi YB, Lipton SA. NMDA receptors: from genes to channels. Trends in Pharmacological Sciences. 17: 348-55. PMID 8979769 DOI: 10.1016/S0165-6147(96)10046-8  0.374
1996 Lipton SA. Similarity of neuronal cell injury and death in AIDS dementia and focal cerebral ischemia: potential treatment with NMDA open-channel blockers and nitric oxide-related species. Brain Pathology (Zurich, Switzerland). 6: 507-17. PMID 8944320 DOI: 10.1111/J.1750-3639.1996.Tb00879.X  0.428
1996 Bonfoco E, Leist M, Zhivotovsky B, Orrenius S, Lipton SA, Nicotera P. Cytoskeletal breakdown and apoptosis elicited by NO donors in cerebellar granule cells require NMDA receptor activation. Journal of Neurochemistry. 67: 2484-93. PMID 8931482 DOI: 10.1046/J.1471-4159.1996.67062484.X  0.406
1996 Lipton SA, Choi YB, Sucher NJ, Pan ZH, Stamler JS. Redox state, NMDA receptors and NO-related species. Trends in Pharmacological Sciences. 17: 186-7;discussion 187. PMID 8669124 DOI: 10.1016/0165-6147(96)20028-8  0.316
1996 Dreyer EB, Zurakowski D, Schumer RA, Podos SM, Lipton SA. Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma. Archives of Ophthalmology (Chicago, Ill. : 1960). 114: 299-305. PMID 8600890 DOI: 10.1001/Archopht.1996.01100130295012  0.369
1996 Lipton SA. Neuronal apoptosis versus necrosis induced by glutamate or free radicals Apoptosis. 1: 5-10. DOI: 10.1007/Bf00142073  0.386
1995 Dreyer EB, Lipton SA. The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid. The European Journal of Neuroscience. 7: 2502-7. PMID 8845955 DOI: 10.1111/j.1460-9568.1995.tb01048.x  0.349
1995 Pan ZH, Bähring R, Grantyn R, Lipton SA. Differential modulation by sulfhydryl redox agents and glutathione of GABA- and glycine-evoked currents in rat retinal ganglion cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 1384-91. PMID 7869105 DOI: 10.1523/Jneurosci.15-02-01384.1995  0.323
1995 Pan ZH, Lipton SA. Multiple GABA receptor subtypes mediate inhibition of calcium influx at rat retinal bipolar cell terminals. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 2668-79. PMID 7722621 DOI: 10.1523/Jneurosci.15-04-02668.1995  0.312
1995 Bading H, Segal MM, Sucher NJ, Dudek H, Lipton SA, Greenberg ME. N-methyl-D-aspartate receptors are critical for mediating the effects of glutamate on intracellular calcium concentration and immediate early gene expression in cultured hippocampal neurons. Neuroscience. 64: 653-64. PMID 7715778 DOI: 10.1016/0306-4522(94)00462-E  0.618
1995 Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, Lipton SA. Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proceedings of the National Academy of Sciences of the United States of America. 92: 7162-6. PMID 7638161 DOI: 10.1073/Pnas.92.16.7162  0.413
1995 Dreyer EB, Zhang D, Lipton SA. Transcriptional or translational inhibition blocks low dose NMDA-mediated cell death. Neuroreport. 6: 942-4. PMID 7612888 DOI: 10.1097/00001756-199504190-00029  0.38
1995 Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA, Nicotera P. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron. 15: 961-73. PMID 7576644 DOI: 10.1016/0896-6273(95)90186-8  0.407
1995 Kater SB, Lipton SA. Neurotransmitter regulation of neuronal outgrowth, plasticity and survival in the year 2001. Trends in Neurosciences. 18: 71-2. PMID 7537415 DOI: 10.1016/0166-2236(95)80025-W  0.315
1995 Dreyer EB, Leifer D, Heng JE, McConnell JE, Gorla M, Levin LA, Barnstable CJ, Lipton SA. An astrocytic binding site for neuronal Thy-1 and its effect on neurite outgrowth. Proceedings of the National Academy of Sciences of the United States of America. 92: 11195-9. PMID 7479964 DOI: 10.1073/pnas.92.24.11195  0.301
1995 Zhang D, Sucher NJ, Lipton SA. Co-expression of AMPA/kainate receptor-operated channels with high and low Ca2+ permeability in single rat retinal ganglion cells. Neuroscience. 67: 177-88. PMID 7477898 DOI: 10.1016/0306-4522(94)00627-H  0.362
1994 Lipton SA. Laboratory basis of novel therapeutic strategies to prevent HIV-related neuronal injury. Research Publications - Association For Research in Nervous and Mental Disease. 72: 183-202. PMID 8115713 DOI: 10.1016/0022-510X(92)90233-B  0.3
1994 Lipton SA. HIV-related neuronal injury. Potential therapeutic intervention with calcium channel antagonists and NMDA antagonists. Molecular Neurobiology. 8: 181-96. PMID 7999315 DOI: 10.1007/BF02780669  0.4
1994 Dreyer EB, Pan ZH, Storm S, Lipton SA. Greater sensitivity of larger retinal ganglion cells to NMDA-mediated cell death. Neuroreport. 5: 629-31. PMID 7912962 DOI: 10.1097/00001756-199401000-00024  0.39
1994 Lipton SA, Rosenberg PA. Excitatory amino acids as a final common pathway for neurologic disorders. The New England Journal of Medicine. 330: 613-22. PMID 7905600 DOI: 10.1056/NEJM199403033300907  0.377
1994 Lipton SA, Singel DJ, Stamler JS. Nitric oxide in the central nervous system. Progress in Brain Research. 103: 359-64. PMID 7886218 DOI: 10.1016/S0079-6123(08)61149-8  0.404
1994 Lipton SA, Yeh M, Dreyer EB. Update on current models of HIV-related neuronal injury: platelet-activating factor, arachidonic acid and nitric oxide. Advances in Neuroimmunology. 4: 181-8. PMID 7874385 DOI: 10.1016/S0960-5428(06)80255-X  0.35
1994 Lipton SA, Stamler JS. Actions of redox-related congeners of nitric oxide at the NMDA receptor. Neuropharmacology. 33: 1229-33. PMID 7870283 DOI: 10.1016/0028-3908(94)90021-3  0.404
1994 Lipton SA. AIDS-related dementia and calcium homeostasis. Annals of the New York Academy of Sciences. 747: 205-24. PMID 7847672 DOI: 10.1111/j.1749-6632.1994.tb44411.x  0.417
1994 Lipton SA. Ca2+, N-methyl-D-aspartate receptors, and AIDS-related neuronal injury. International Review of Neurobiology. 36: 1-27. PMID 7822116 DOI: 10.1016/S0074-7742(08)60301-3  0.404
1994 Lipton SA. Neuronal injury associated with HIV-1 and potential treatment with calcium-channel and NMDA antagonists. Developmental Neuroscience. 16: 145-51. PMID 7705221 DOI: 10.1159/000112101  0.418
1994 Sullivan JM, Traynelis SF, Chen HS, Escobar W, Heinemann SF, Lipton SA. Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor. Neuron. 13: 929-36. PMID 7524561 DOI: 10.1016/0896-6273(94)90258-5  0.377
1993 Lipton SA, Choi YB, Pan ZH, Lei SZ, Chen HS, Sucher NJ, Loscalzo J, Singel DJ, Stamler JS. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature. 364: 626-32. PMID 8394509 DOI: 10.1038/364626A0  0.389
1993 Pellegrini JW, Lipton SA. Delayed administration of memantine prevents N-methyl-D-aspartate receptor-mediated neurotoxicity. Annals of Neurology. 33: 403-7. PMID 8098195 DOI: 10.1002/ana.410330414  0.42
1993 Lipton SA. Prospects for clinically tolerated NMDA antagonists: open-channel blockers and alternative redox states of nitric oxide. Trends in Neurosciences. 16: 527-32. PMID 7509524 DOI: 10.1016/0166-2236(93)90198-U  0.38
1992 Lipton SA. 7-Chlorokynurenate Ameliorates Neuronal Injury Mediated by HIV Envelope Protein gp120 in Rodent Retinal Cultures. The European Journal of Neuroscience. 4: 1411-1415. PMID 12106405 DOI: 10.1111/j.1460-9568.1992.tb00167.x  0.423
1992 Lipton SA. Memantine prevents HIV coat protein-induced neuronal injury in vitro. Neurology. 42: 1403-5. PMID 1620355 DOI: 10.1212/Wnl.42.7.1403  0.404
1992 Lei SZ, Zhang D, Abele AE, Lipton SA. Blockade of NMDA receptor-mediated mobilization of intracellular Ca2+ prevents neurotoxicity. Brain Research. 598: 196-202. PMID 1486480 DOI: 10.1016/0006-8993(92)90183-A  0.328
1992 Chen HS, Pellegrini JW, Aggarwal SK, Lei SZ, Warach S, Jensen FE, Lipton SA. Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 4427-36. PMID 1432103 DOI: 10.1523/Jneurosci.12-11-04427.1992  0.419
1992 Lipton SA. Requirement for macrophages in neuronal injury induced by HIV envelope protein gp120. Neuroreport. 3: 913-5. PMID 1421098 DOI: 10.1097/00001756-199210000-00023  0.377
1992 Frosch MP, Lipton SA, Dichter MA. Desensitization of GABA-activated currents and channels in cultured cortical neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 3042-53. PMID 1379634 DOI: 10.1523/Jneurosci.12-08-03042.1992  0.329
1992 Lei SZ, Pan ZH, Aggarwal SK, Chen HS, Hartman J, Sucher NJ, Lipton SA. Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex. Neuron. 8: 1087-99. PMID 1376999 DOI: 10.1016/0896-6273(92)90130-6  0.4
1992 Lipton SA. Models of neuronal injury in AIDS: another role for the NMDA receptor? Trends in Neurosciences. 15: 75-9. PMID 1373919 DOI: 10.1016/0166-2236(92)90013-X  0.4
1992 Zhang D, Lipton SA. L-homocysteic acid selectively activates N-methyl-D-aspartate receptors of rat retinal ganglion cells. Neuroscience Letters. 139: 173-7. PMID 1351663 DOI: 10.1016/0304-3940(92)90545-I  0.37
1991 Budson AE, Jackson PS, Lipton SA. GDP beta S antagonizes whole-cell current responses to excitatory amino acids. Brain Research. 548: 346-8. PMID 1868345 DOI: 10.1016/0006-8993(91)91147-S  0.338
1991 Levy DI, Sucher NJ, Lipton SA. Glutathione prevents N-methyl-D-aspartate receptor-mediated neurotoxicity. Neuroreport. 2: 345-7. PMID 1832987 DOI: 10.1097/00001756-199106000-00011  0.411
1991 Sucher NJ, Cheng TP, Lipton SA. Cryopreservation of postnatal rat retinal ganglion cells: persistence of voltage- and ligand-gated ionic currents. Neuroscience. 43: 135-50. PMID 1717883 DOI: 10.1016/0306-4522(91)90423-L  0.309
1991 Sucher NJ, Lei SZ, Lipton SA. Calcium channel antagonists attenuate NMDA receptor-mediated neurotoxicity of retinal ganglion cells in culture. Brain Research. 551: 297-302. PMID 1680525 DOI: 10.1016/0006-8993(91)90944-Q  0.389
1991 Lipton SA, Sucher NJ, Kaiser PK, Dreyer EB. Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity. Neuron. 7: 111-8. PMID 1676893 DOI: 10.1016/0896-6273(91)90079-F  0.407
1991 Sucher NJ, Aizenman E, Lipton SA. N-methyl-D-aspartate antagonists prevent kainate neurotoxicity in rat retinal ganglion cells in vitro. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 11: 966-71. PMID 1672708 DOI: 10.1523/Jneurosci.11-04-00966.1991  0.636
1991 Lipton SA. HIV-related neurotoxicity. Brain Pathology (Zurich, Switzerland). 1: 193-9. PMID 1669708 DOI: 10.1111/j.1750-3639.1991.tb00659.x  0.405
1991 Sucher NJ, Lipton SA. Redox modulatory site of the NMDA receptor-channel complex: regulation by oxidized glutathione. Journal of Neuroscience Research. 30: 582-91. PMID 1666131 DOI: 10.1002/jnr.490300316  0.409
1991 Lipton SA. Calcium channel antagonists and human immunodeficiency virus coat protein-mediated neuronal injury. Annals of Neurology. 30: 110-4. PMID 1656845 DOI: 10.1002/ana.410300121  0.35
1990 Aizenman E, Loring RH, Lipton SA. Blockade of nicotinic responses in rat retinal ganglion cells by neuronal bungarotoxin. Brain Research. 517: 209-14. PMID 2375991 DOI: 10.1016/0006-8993(90)91028-F  0.59
1990 Dreyer EB, Kaiser PK, Offermann JT, Lipton SA. HIV-1 coat protein neurotoxicity prevented by calcium channel antagonists Science. 248: 364-367. PMID 2326646 DOI: 10.1126/Science.2326646  0.311
1990 Sucher NJ, Cheng TP, Lipton SA. Neural nicotinic acetylcholine responses in sensory neurons from postnatal rat. Brain Research. 533: 248-54. PMID 2289141 DOI: 10.1016/0006-8993(90)91346-I  0.324
1990 Kaiser PK, Offermann JT, Lipton SA. Neuronal injury due to HIV-1 envelope protein is blocked by anti-gp120 antibodies but not by anti-CD4 antibodies. Neurology. 40: 1757-61. PMID 2234433 DOI: 10.1212/Wnl.40.11.1757  0.307
1990 Kaiser PK, Lipton SA. VIP-mediated increase in cAMP prevents tetrodotoxin-induced retinal ganglion cell death in vitro. Neuron. 5: 373-81. PMID 2169272 DOI: 10.1016/0896-6273(90)90173-D  0.34
1990 Sucher NJ, Wong LA, Lipton SA. Redox modulation of NMDA receptor-mediated Ca2+ flux in mammalian central neurons. Neuroreport. 1: 29-32. PMID 2151794 DOI: 10.1097/00001756-199009000-00009  0.355
1990 Levy DI, Lipton SA. Comparison of delayed administration of competitive and uncompetitive antagonists in preventing NMDA receptor-mediated neuronal death Neurology. 40: 852-855. PMID 1970428 DOI: 10.1212/Wnl.40.5.852  0.435
1990 Levy DI, Sucher NJ, Lipton SA. Redox modulation of NMDA receptor-mediated toxicity in mammalian central neurons Neuroscience Letters. 110: 291-296. PMID 1970145 DOI: 10.1016/0304-3940(90)90862-4  0.451
1989 Loring RH, Aizenman E, Lipton SA, Zigmond RE. Characterization of nicotinic receptors in chick retina using a snake venom neurotoxin that blocks neuronal nicotinic receptor function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 9: 2423-31. PMID 2746336 DOI: 10.1523/Jneurosci.09-07-02423.1989  0.578
1989 Aizenman E, Lipton SA, Loring RH. Selective modulation of NMDA responses by reduction and oxidation. Neuron. 2: 1257-63. PMID 2696504 DOI: 10.1016/0896-6273(89)90310-3  0.63
1989 Aizenman E, Karschin A, Lipton SA. Two pharmacological classes of quisqualate-induced electrical responses in rat retinal ganglion cells in vitro. European Journal of Pharmacology. 174: 9-22. PMID 2575535 DOI: 10.1016/0014-2999(89)90868-6  0.586
1989 Lipton SA. Growth Factors for Neuronal Survival and Process Regeneration: Implications in the Mammalian Central Nervous System Archives of Neurology. 46: 1241-1248. PMID 2573331 DOI: 10.1001/archneur.1989.00520470113038  0.35
1989 Karschin A, Lipton SA. Calcium channels in solitary retinal ganglion cells from post-natal rat Journal of Physiology. 418: 379-396. PMID 2559971 DOI: 10.1113/Jphysiol.1989.Sp017847  0.313
1989 Lipton SA, Kater SB. Neurotransmitter regulation of neuronal outgrowth, plasticity and survival. Trends in Neurosciences. 12: 265-70. PMID 2475939 DOI: 10.1016/0166-2236(89)90026-X  0.369
1988 Lipton SA, Wagner JA, Madison RD, D'Amore PA. Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture Proceedings of the National Academy of Sciences of the United States of America. 85: 2388-2392. PMID 3353388 DOI: 10.1073/Pnas.85.7.2388  0.301
1988 Lipton SA, Frosch MP, Phillips MD, Tauck DL, Aizenman E. Nicotinic antagonists enhance process outgrowth by rat retinal ganglion cells in culture. Science (New York, N.Y.). 239: 1293-6. PMID 3344435 DOI: 10.1126/Science.3344435  0.583
1988 Lipton SA. Spontaneous release of acetylcholine affects the physiological nicotinic responses of rat retinal ganglion cells in culture Journal of Neuroscience. 8: 3857-3868. PMID 2903915 DOI: 10.1523/Jneurosci.08-10-03857.1988  0.312
1988 Hahn JS, Aizenman E, Lipton SA. Central mammalian neurons normally resistant to glutamate toxicity are made sensitive by elevated extracellular Ca2+: toxicity is blocked by the N-methyl-D-aspartate antagonist MK-801. Proceedings of the National Academy of Sciences of the United States of America. 85: 6556-60. PMID 2901101 DOI: 10.1073/Pnas.85.17.6556  0.64
1988 Aizenman E, Frosch MP, Lipton SA. Responses mediated by excitatory amino acid receptors in solitary retinal ganglion cells from rat. The Journal of Physiology. 396: 75-91. PMID 2842491 DOI: 10.1113/Jphysiol.1988.Sp016951  0.6
1988 Karschin A, Aizenman E, Lipton SA. The interaction of agonists and noncompetitive antagonists at the excitatory amino acid receptors in rat retinal ganglion cells in vitro. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 8: 2895-906. PMID 2842467 DOI: 10.1523/Jneurosci.08-08-02895.1988  0.624
1987 Lipton SA, Aizenman E, Loring RH. Neural nicotinic acetylcholine responses in solitary mammalian retinal ganglion cells. Pflã¼Gers Archiv : European Journal of Physiology. 410: 37-43. PMID 3684508 DOI: 10.1007/Bf00581893  0.58
1987 Lipton SA. Bursting of calcium-activated cation-selective channels is associated with neurite regeneration in a mammalian central neuron Neuroscience Letters. 82: 21-28. PMID 2447529 DOI: 10.1016/0304-3940(87)90165-0  0.337
1987 Lipton SA, Tauck DL. Voltage-dependent conductances of solitary ganglion cells dissociated from the rat retina. The Journal of Physiology. 385: 361-91. PMID 2443669 DOI: 10.1113/Jphysiol.1987.Sp016497  0.3
1986 Lipton SA. Blockade of electrical activity promotes the death of mammalian retinal ganglion cells in culture Proceedings of the National Academy of Sciences of the United States of America. 83: 9774-9778. PMID 3025849 DOI: 10.1073/Pnas.83.24.9774  0.375
1981 Lipton SA, Dowling JE. Chapter 21 The Relation between Ca2+ and Cyclic GMP in Rod Photoreceptors Current Topics in Membranes and Transport. 15: 381-392. DOI: 10.1016/S0070-2161(08)60512-2  0.385
1979 Lipton SA, Ostroy SE, Dowling JE. Ca2+ and photoreceptor adaptation. Nature. 281: 407-8. PMID 481607 DOI: 10.1038/281407c0  0.445
1977 Lipton SA, Ostroy SE, Dowling JE. Electrical and adaptive properties of rod photoreceptors in Bufo marinus. I. Effects of altered extracellular Ca2+ levels. The Journal of General Physiology. 70: 747-70. PMID 412914 DOI: 10.1085/Jgp.70.6.747  0.491
1977 Lipton SA, Rasmussen H, Dowling JE. Electrical and adaptive properties of rod photoreceptors in Bufo marinus. II. Effects of cyclic nucleotides and prostaglandins. The Journal of General Physiology. 70: 771-91. PMID 201724 DOI: 10.1085/Jgp.70.6.771  0.495
Show low-probability matches.