Stuart A. Lipton - Publications

Affiliations: 
Scripps Research Institute, La Jolla, La Jolla, CA, United States 
 Neurosciences University of California, San Diego, La Jolla, CA 
Area:
Neurodegenerative Disease
Website:
https://www.scripps.edu/research/faculty/lipton

121 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Trudler D, Sanz-Blasco S, Eisele YS, Ghatak S, Bodhinathan K, Akhtar MW, Lynch WP, Piña-Crespo JC, Talantova M, Kelly JW, Lipton SA. α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 33483428 DOI: 10.1523/JNEUROSCI.1871-20.2020  0.766
2020 Ghatak S, Dolatabadi N, Gao R, Wu Y, Scott H, Trudler D, Sultan A, Ambasudhan R, Nakamura T, Masliah E, Talantova M, Voytek B, Lipton SA. NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models. Molecular Psychiatry. PMID 32467645 DOI: 10.1038/S41380-020-0776-7  0.311
2019 Ghatak S, Dolatabadi N, Trudler D, Zhang X, Wu Y, Mohata M, Ambasudhan R, Talantova M, Lipton SA. Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs. isogenic control. Elife. 8. PMID 31782729 DOI: 10.7554/Elife.50333  0.337
2019 Okamoto SI, Prikhodko O, Pina-Crespo J, Adame A, McKercher SR, Brill LM, Nakanishi N, Oh CK, Nakamura T, Masliah E, Lipton SA. NitroSynapsin for the treatment of neurological manifestations of tuberous sclerosis complex in a rodent model. Neurobiology of Disease. PMID 30928642 DOI: 10.1016/J.Nbd.2019.03.029  0.714
2019 Ghatak S, Dolatabadi N, Trudler D, Zhang X, Wu Y, Mohata M, Ambasudhan R, Talantova M, Lipton SA. Author response: Mechanisms of hyperexcitability in Alzheimer’s disease hiPSC-derived neurons and cerebral organoids vs isogenic controls Elife. DOI: 10.7554/Elife.50333.Sa2  0.315
2018 Ryan T, Bamm VV, Stykel MG, Coackley CL, Humphries KM, Jamieson-Williams R, Ambasudhan R, Mosser DD, Lipton SA, Harauz G, Ryan SD. Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein. Nature Communications. 9: 817. PMID 29483518 DOI: 10.1038/S41467-018-03241-9  0.591
2017 Connolly NMC, Theurey P, Adam-Vizi V, Bazan NG, Bernardi P, Bolaños JP, Culmsee C, Dawson VL, Deshmukh M, Duchen MR, Düssmann H, Fiskum G, Galindo MF, Hardingham GE, Hardwick JM, ... ... Lipton SA, et al. Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases. Cell Death and Differentiation. PMID 29229998 DOI: 10.1038/S41418-017-0020-4  0.524
2017 Oh CK, Sultan A, Platzer J, Dolatabadi N, Soldner F, McClatchy DB, Diedrich JK, Yates JR, Ambasudhan R, Nakamura T, Jaenisch R, Lipton SA. S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson's Disease Models. Cell Reports. 21: 2171-2182. PMID 29166608 DOI: 10.1016/J.Celrep.2017.10.068  0.322
2017 Tu S, Akhtar MW, Escorihuela RM, Amador-Arjona A, Swarup V, Parker J, Zaremba JD, Holland T, Bansal N, Holohan DR, Lopez K, Ryan SD, Chan SF, Yan L, Zhang X, ... ... Lipton SA, et al. NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism. Nature Communications. 8: 1488. PMID 29133852 DOI: 10.1038/S41467-017-01563-8  0.71
2017 Nagar S, Trudler D, McKercher SR, Piña-Crespo J, Nakanishi N, Okamoto SI, Lipton SA. Molecular Pathway to Protection From Age-Dependent Photoreceptor Degeneration in Mef2 Deficiency. Investigative Ophthalmology & Visual Science. 58: 3741-3749. PMID 28738418 DOI: 10.1167/iovs.17-21767  0.718
2017 Nagar S, Noveral SM, Trudler D, Lopez KM, McKercher SR, Han X, Yates JR, Piña-Crespo JC, Nakanishi N, Satoh T, Okamoto SI, Lipton SA. MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. PMID 28461502 DOI: 10.1073/Pnas.1613067114  0.724
2016 Lipton SA, Rezaie T, Nutter A, Lopez KM, Parker J, Kosaka K, Satoh T, McKercher SR, Masliah E, Nakanishi N. Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer's disease models. Cell Death & Disease. 7: e2499. PMID 27906174 DOI: 10.1038/Cddis.2016.389  0.317
2016 Sunico CR, Sultan A, Nakamura T, Dolatabadi N, Parker J, Shan B, Han X, Yates JR, Masliah E, Ambasudhan R, Nakanishi N, Lipton SA. Role of sulfiredoxin as a peroxiredoxin-2 denitrosylase in human iPSC-derived dopaminergic neurons. Proceedings of the National Academy of Sciences of the United States of America. PMID 27821734 DOI: 10.1073/Pnas.1608784113  0.349
2016 Sanz-Blasco S, Piña-Crespo JC, Zhang X, McKercher SR, Lipton SA. Levetiracetam inhibits oligomeric Aβ-induced glutamate release from human astrocytes. Neuroreport. PMID 27183239 DOI: 10.1097/Wnr.0000000000000601  0.319
2016 Jiang J, Chan A, Ali S, Saha A, Haushalter KJ, Lam WM, Glasheen M, Parker J, Brenner M, Mahon SB, Patel HH, Ambasudhan R, Lipton SA, Pilz RB, Boss GR. Hydrogen Sulfide-Mechanisms of Toxicity and Development of an Antidote. Scientific Reports. 6: 20831. PMID 26877209 DOI: 10.1038/Srep20831  0.303
2016 Takahashi H, Xia P, Cui J, Talantova M, Bodhinathan K, Li W, Saleem S, Holland EA, Tong G, Piña-Crespo J, Zhang D, Nakanishi N, Larrick JW, McKercher SR, Nakamura T, ... ... Lipton SA, et al. Corrigendum: Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease. Scientific Reports. 6: 20750. PMID 26867695 DOI: 10.1038/srep20750  0.754
2016 Akhtar MW, Sanz-Blasco S, Dolatabadi N, Parker J, Chon K, Lee MS, Soussou W, McKercher SR, Ambasudhan R, Nakamura T, Lipton SA. Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation. Nature Communications. 7: 10242. PMID 26743041 DOI: 10.1038/Ncomms10242  0.735
2015 Takahashi H, Xia P, Cui J, Talantova M, Bodhinathan K, Li W, Holland EA, Tong G, Piña-Crespo J, Zhang D, Nakanishi N, Larrick JW, McKercher SR, Nakamura T, Wang Y, ... Lipton SA, et al. Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease. Scientific Reports. 5: 14781. PMID 26477507 DOI: 10.1038/srep14781  0.771
2015 Nakato R, Ohkubo Y, Konishi A, Shibata M, Kaneko Y, Iwawaki T, Nakamura T, Lipton SA, Uehara T. Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress. Scientific Reports. 5: 14812. PMID 26446798 DOI: 10.1038/srep14812  0.315
2015 Nakanishi N, Kang YJ, Tu S, McKercher SR, Masliah E, Lipton SA. Differential Effects of Pharmacologic and Genetic Modulation of NMDA Receptor Activity on HIV/gp120-Induced Neuronal Damage in an In Vivo Mouse Model. Journal of Molecular Neuroscience : Mn. PMID 26374431 DOI: 10.1007/S12031-015-0651-1  0.351
2015 Yang B, Qu M, Wang R, Chatterton JE, Liu XB, Zhu B, Narisawa S, Millan JL, Nakanishi N, Swoboda K, Lipton SA, Zhang D. The critical role of membralin in postnatal motor neuron survival and disease. Elife. 4. PMID 25977983 DOI: 10.7554/eLife.06500  0.32
2015 Nakamura T, Prikhodko OA, Pirie E, Nagar S, Akhtar MW, Oh CK, McKercher SR, Ambasudhan R, Okamoto SI, Lipton SA. Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases. Neurobiology of Disease. PMID 25796565 DOI: 10.1016/j.nbd.2015.03.017  0.34
2015 Zhang D, Lee B, Nutter A, Song P, Dolatabadi N, Parker J, Sanz-Blasco S, Newmeyer T, Ambasudhan R, McKercher SR, Masliah E, Lipton SA. Protection from cyanide-induced brain injury by the Nrf2 transcriptional activator carnosic acid. Journal of Neurochemistry. 133: 898-908. PMID 25692407 DOI: 10.1111/Jnc.13074  0.338
2015 Chan SF, Huang X, McKercher SR, Zaidi R, Okamoto SI, Nakanishi N, Lipton SA. Transcriptional profiling of MEF2-regulated genes in human neural progenitor cells derived from embryonic stem cells. Genomics Data. 3: 24-27. PMID 25485232 DOI: 10.1016/j.gdata.2014.10.022  0.301
2014 Tu S, Okamoto S, Lipton SA, Xu H. Oligomeric Aβ-induced synaptic dysfunction in Alzheimer's disease. Molecular Neurodegeneration. 9: 48. PMID 25394486 DOI: 10.1186/1750-1326-9-48  0.343
2014 Choi MS, Nakamura T, Cho SJ, Han X, Holland EA, Qu J, Petsko GA, Yates JR, Liddington RC, Lipton SA. Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 15123-31. PMID 25378175 DOI: 10.1523/Jneurosci.4751-13.2014  0.334
2014 Okamoto S, Nakamura T, Cieplak P, Chan SF, Kalashnikova E, Liao L, Saleem S, Han X, Clemente A, Nutter A, Sances S, Brechtel C, Haus D, Haun F, Sanz-Blasco S, ... ... Lipton SA, et al. S-nitrosylation-mediated redox transcriptional switch modulates neurogenesis and neuronal cell death. Cell Reports. 8: 217-28. PMID 25001280 DOI: 10.1016/J.Celrep.2014.06.005  0.582
2014 Ambasudhan R, Dolatabadi N, Nutter A, Masliah E, Mckercher SR, Lipton SA. Potential for cell therapy in Parkinson's disease using genetically programmed human embryonic stem cell-derived neural progenitor cells. The Journal of Comparative Neurology. 522: 2845-56. PMID 24756727 DOI: 10.1002/Cne.23617  0.306
2014 Molokanova E, Akhtar MW, Sanz-Blasco S, Tu S, Piña-Crespo JC, McKercher SR, Lipton SA. Differential effects of synaptic and extrasynaptic NMDA receptors on Aβ-induced nitric oxide production in cerebrocortical neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 5023-8. PMID 24695719 DOI: 10.1523/Jneurosci.2907-13.2014  0.749
2014 Zhu S, Ambasudhan R, Sun W, Kim HJ, Talantova M, Wang X, Zhang M, Zhang Y, Laurent T, Parker J, Kim HS, Zaremba JD, Saleem S, Sanz-Blasco S, Masliah E, ... ... Lipton SA, et al. Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells. Cell Research. 24: 126-9. PMID 24296783 DOI: 10.1038/Cr.2013.156  0.545
2013 Ryan SD, Dolatabadi N, Chan SF, Zhang X, Akhtar MW, Parker J, Soldner F, Sunico CR, Nagar S, Talantova M, Lee B, Lopez K, Nutter A, Shan B, Molokanova E, ... ... Lipton SA, et al. Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription. Cell. 155: 1351-64. PMID 24290359 DOI: 10.1016/J.Cell.2013.11.009  0.592
2013 Nakanishi N, Ryan SD, Zhang X, Khan A, Holland T, Cho EG, Huang X, Liao FF, Xu H, Lipton SA, Tu S. Synaptic protein α1-takusan mitigates amyloid-β-induced synaptic loss via interaction with tau and postsynaptic density-95 at postsynaptic sites. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 14170-83. PMID 23986251 DOI: 10.1523/Jneurosci.4646-10.2013  0.589
2013 Sunico CR, Nakamura T, Rockenstein E, Mante M, Adame A, Chan SF, Newmeyer TF, Masliah E, Nakanishi N, Lipton SA. S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's disease. Molecular Neurodegeneration. 8: 29. PMID 23985028 DOI: 10.1186/1750-1326-8-29  0.302
2013 Marco S, Giralt A, Petrovic MM, Pouladi MA, Martínez-Turrillas R, Martínez-Hernández J, Kaltenbach LS, Torres-Peraza J, Graham RK, Watanabe M, Luján R, Nakanishi N, Lipton SA, Lo DC, Hayden MR, et al. Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models. Nature Medicine. 19: 1030-8. PMID 23852340 DOI: 10.1038/Nm.3246  0.358
2013 Talantova M, Sanz-Blasco S, Zhang X, Xia P, Akhtar MW, Okamoto S, Dziewczapolski G, Nakamura T, Cao G, Pratt AE, Kang YJ, Tu S, Molokanova E, McKercher SR, Hires SA, ... ... Lipton SA, et al. Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. Proceedings of the National Academy of Sciences of the United States of America. 110: E2518-27. PMID 23776240 DOI: 10.1073/Pnas.1306832110  0.74
2013 Haun F, Nakamura T, Shiu AD, Cho DH, Tsunemi T, Holland EA, La Spada AR, Lipton SA. S-nitrosylation of dynamin-related protein 1 mediates mutant huntingtin-induced mitochondrial fragmentation and neuronal injury in Huntington's disease. Antioxidants & Redox Signaling. 19: 1173-84. PMID 23641925 DOI: 10.1089/ars.2012.4928  0.326
2013 Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, ... ... Lipton SA, et al. Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nature Medicine. 19: 473-80. PMID 23524343 DOI: 10.1038/Nm.3117  0.327
2013 Shi ZQ, Sunico CR, McKercher SR, Cui J, Feng GS, Nakamura T, Lipton SA. S-nitrosylated SHP-2 contributes to NMDA receptor-mediated excitotoxicity in acute ischemic stroke. Proceedings of the National Academy of Sciences of the United States of America. 110: 3137-42. PMID 23382182 DOI: 10.1073/Pnas.1215501110  0.355
2013 Ambasudhan R, Parker J, Ainza C, Dolatabadi N, Ryan S, Le T, Lipton SA, Haas RH. A human reprogrammed-cell model of MELAS Mitochondrion. 13: 943-944. DOI: 10.1016/j.mito.2013.07.112  0.563
2012 Piña-Crespo JC, Talantova M, Cho EG, Soussou W, Dolatabadi N, Ryan SD, Ambasudhan R, McKercher S, Deisseroth K, Lipton SA. High-frequency hippocampal oscillations activated by optogenetic stimulation of transplanted human ESC-derived neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15837-42. PMID 23136422 DOI: 10.1523/Jneurosci.3735-12.2012  0.764
2012 Qu J, Nakamura T, Holland EA, McKercher SR, Lipton SA. S-nitrosylation of Cdk5: potential implications in amyloid-β-related neurotoxicity in Alzheimer disease. Prion. 6: 364-70. PMID 22874667 DOI: 10.4161/pri.21250  0.346
2012 Henson MA, Larsen RS, Lawson SN, Pérez-Otaño I, Nakanishi N, Lipton SA, Philpot BD. Genetic deletion of NR3A accelerates glutamatergic synapse maturation. Plos One. 7: e42327. PMID 22870318 DOI: 10.1371/Journal.Pone.0042327  0.321
2011 Cho EG, Zaremba JD, McKercher SR, Talantova M, Tu S, Masliah E, Chan SF, Nakanishi N, Terskikh A, Lipton SA. MEF2C enhances dopaminergic neuron differentiation of human embryonic stem cells in a parkinsonian rat model. Plos One. 6: e24027. PMID 21901155 DOI: 10.1371/Journal.Pone.0024027  0.587
2011 Qu J, Nakamura T, Cao G, Holland EA, McKercher SR, Lipton SA. S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptide. Proceedings of the National Academy of Sciences of the United States of America. 108: 14330-5. PMID 21844361 DOI: 10.1073/pnas.1105172108  0.311
2011 Meng F, Yao D, Shi Y, Kabakoff J, Wu W, Reicher J, Ma Y, Moosmann B, Masliah E, Lipton SA, Gu Z. Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation. Molecular Neurodegeneration. 6: 34. PMID 21595948 DOI: 10.1186/1750-1326-6-34  0.306
2011 Kim J, Efe JA, Zhu S, Talantova M, Yuan X, Wang S, Lipton SA, Zhang K, Ding S. Direct reprogramming of mouse fibroblasts to neural progenitors. Proceedings of the National Academy of Sciences of the United States of America. 108: 7838-43. PMID 21521790 DOI: 10.1073/Pnas.1103113108  0.309
2011 Larsen RS, Corlew RJ, Henson MA, Roberts AC, Mishina M, Watanabe M, Lipton SA, Nakanishi N, Pérez-Otaño I, Weinberg RJ, Philpot BD. NR3A-containing NMDARs promote neurotransmitter release and spike timing-dependent plasticity. Nature Neuroscience. 14: 338-44. PMID 21297630 DOI: 10.1038/Nn.2750  0.307
2011 Krajewska M, Xu L, Xu W, Krajewski S, Kress CL, Cui J, Yang L, Irie F, Yamaguchi Y, Lipton SA, Reed JC. Endoplasmic reticulum protein BI-1 modulates unfolded protein response signaling and protects against stroke and traumatic brain injury. Brain Research. 1370: 227-37. PMID 21075086 DOI: 10.1016/j.brainres.2010.11.015  0.301
2010 Kwak YD, Ma T, Diao S, Zhang X, Chen Y, Hsu J, Lipton SA, Masliah E, Xu H, Liao FF. NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration. Molecular Neurodegeneration. 5: 49. PMID 21067594 DOI: 10.1186/1750-1326-5-49  0.324
2010 Piña-Crespo JC, Talantova M, Micu I, States B, Chen HS, Tu S, Nakanishi N, Tong G, Zhang D, Heinemann SF, Zamponi GW, Stys PK, Lipton SA. Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11501-5. PMID 20739572 DOI: 10.1523/Jneurosci.1593-10.2010  0.726
2010 Xia K, Xiong H, Shin Y, Wang D, Deerinck T, Takahashi H, Ellisman MH, Lipton SA, Tong G, Descalzi G, Zhang D, Zhuo M, Zhang Z. Roles of KChIP1 in the regulation of GABA-mediated transmission and behavioral anxiety. Molecular Brain. 3: 23. PMID 20678225 DOI: 10.1186/1756-6606-3-23  0.323
2010 Nakamura T, Wang L, Wong CC, Scott FL, Eckelman BP, Han X, Tzitzilonis C, Meng F, Gu Z, Holland EA, Clemente AT, Okamoto S, Salvesen GS, Riek R, Yates JR, ... Lipton SA, et al. Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death. Molecular Cell. 39: 184-95. PMID 20670888 DOI: 10.1016/J.Molcel.2010.07.002  0.333
2010 Gu Z, Nakamura T, Lipton SA. Redox reactions induced by nitrosative stress mediate protein misfolding and mitochondrial dysfunction in neurodegenerative diseases. Molecular Neurobiology. 41: 55-72. PMID 20333559 DOI: 10.1007/S12035-010-8113-9  0.34
2010 Zhao LC, Yang B, Wang R, Lipton SA, Zhang D. Type C botulinum toxin causes degeneration of motoneurons in vivo. Neuroreport. 21: 14-8. PMID 19907349 DOI: 10.1097/WNR.0b013e328330dcca  0.311
2010 Seki M, Soussou W, Manabe S, Lipton SA. Protection of retinal ganglion cells by caspase substrate-binding peptide IQACRG from N-methyl-D-aspartate receptor-mediated excitotoxicity. Investigative Ophthalmology & Visual Science. 51: 1198-207. PMID 19815732 DOI: 10.1167/Iovs.09-4102  0.721
2010 Sanz-Blasco S, Piña-Crespo J, Talantova M, Lipton S. P2-288: Abeta-mediated glutamate release from astrocytes Alzheimer's & Dementia. 6: S398-S398. DOI: 10.1016/J.Jalz.2010.05.1338  0.714
2009 Okamoto S, Pouladi MA, Talantova M, Yao D, Xia P, Ehrnhoefer DE, Zaidi R, Clemente A, Kaul M, Graham RK, Zhang D, Vincent Chen HS, Tong G, Hayden MR, Lipton SA. Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin. Nature Medicine. 15: 1407-13. PMID 19915593 DOI: 10.1038/Nm.2056  0.378
2009 Cho DH, Nakamura T, Fang J, Cieplak P, Godzik A, Gu Z, Lipton SA. S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science (New York, N.Y.). 324: 102-5. PMID 19342591 DOI: 10.1126/Science.1171091  0.336
2009 Bajpai R, Coppola G, Kaul M, Talantova M, Cimadamore F, Nilbratt M, Geschwind DH, Lipton SA, Terskikh AV. Molecular stages of rapid and uniform neuralization of human embryonic stem cells. Cell Death and Differentiation. 16: 807-25. PMID 19282867 DOI: 10.1038/Cdd.2009.18  0.303
2009 Lipton SA, Li H, Zaremba JD, McKercher SR, Cui J, Kang YJ, Nie Z, Soussou W, Talantova M, Okamoto S, Nakanishi N. Autistic phenotype from MEF2C knockout cells. Science (New York, N.Y.). 323: 208. PMID 19131610 DOI: 10.1126/Science.323.5911.208B  0.753
2008 Li H, Radford JC, Ragusa MJ, Shea KL, McKercher SR, Zaremba JD, Soussou W, Nie Z, Kang YJ, Nakanishi N, Okamoto S, Roberts AJ, Schwarz JJ, Lipton SA. Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. Proceedings of the National Academy of Sciences of the United States of America. 105: 9397-402. PMID 18599437 DOI: 10.1073/Pnas.0802876105  0.772
2008 Li Z, McKercher SR, Cui J, Nie Z, Soussou W, Roberts AJ, Sallmen T, Lipton JH, Talantova M, Okamoto S, Lipton SA. Myocyte enhancer factor 2C as a neurogenic and antiapoptotic transcription factor in murine embryonic stem cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6557-68. PMID 18579729 DOI: 10.1523/Jneurosci.0134-08.2008  0.737
2008 Tong G, Takahashi H, Tu S, Shin Y, Talantova M, Zago W, Xia P, Nie Z, Goetz T, Zhang D, Lipton SA, Nakanishi N. Modulation of NMDA receptor properties and synaptic transmission by the NR3A subunit in mouse hippocampal and cerebrocortical neurons. Journal of Neurophysiology. 99: 122-32. PMID 18003876 DOI: 10.1152/jn.01044.2006  0.538
2008 Satoh T, Kosaka K, Itoh K, Kobayashi A, Yamamoto M, Shimojo Y, Kitajima C, Cui J, Kamins J, Okamoto S, Izumi M, Shirasawa T, Lipton SA. Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1. Journal of Neurochemistry. 104: 1116-31. PMID 17995931 DOI: 10.1111/J.1471-4159.2007.05039.X  0.321
2008 Nakagomi S, Barsoum MJ, Bossy-Wetzel E, Sütterlin C, Malhotra V, Lipton SA. A Golgi fragmentation pathway in neurodegeneration. Neurobiology of Disease. 29: 221-31. PMID 17964175 DOI: 10.1016/J.Nbd.2007.08.015  0.321
2007 Fang J, Nakamura T, Cho DH, Gu Z, Lipton SA. S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 104: 18742-7. PMID 18003920 DOI: 10.1073/Pnas.0705904104  0.316
2007 Alirezaei M, Watry DD, Flynn CF, Kiosses WB, Masliah E, Williams BR, Kaul M, Lipton SA, Fox HS. Human immunodeficiency virus-1/surface glycoprotein 120 induces apoptosis through RNA-activated protein kinase signaling in neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 11047-55. PMID 17928446 DOI: 10.1523/Jneurosci.2733-07.2007  0.339
2007 Lipton SA, Gu Z, Nakamura T. Inflammatory mediators leading to protein misfolding and uncompetitive/fast off-rate drug therapy for neurodegenerative disorders. International Review of Neurobiology. 82: 1-27. PMID 17678953 DOI: 10.1016/S0074-7742(07)82001-0  0.363
2007 Redmond DE, Bjugstad KB, Teng YD, Ourednik V, Ourednik J, Wakeman DR, Parsons XH, Gonzalez R, Blanchard BC, Kim SU, Gu Z, Lipton SA, Markakis EA, Roth RH, Elsworth JD, et al. Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 12175-80. PMID 17586681 DOI: 10.1073/Pnas.0704091104  0.308
2007 Lee JP, Jeyakumar M, Gonzalez R, Takahashi H, Lee PJ, Baek RC, Clark D, Rose H, Fu G, Clarke J, McKercher S, Meerloo J, Muller FJ, Park KI, Butters TD, ... ... Lipton SA, et al. Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease. Nature Medicine. 13: 439-47. PMID 17351625 DOI: 10.1038/Nm1548  0.335
2007 Choi WT, Kaul M, Kumar S, Wang J, Kumar IM, Dong CZ, An J, Lipton SA, Huang Z. Neuronal apoptotic signaling pathways probed and intervened by synthetically and modularly modified (SMM) chemokines. The Journal of Biological Chemistry. 282: 7154-63. PMID 17218311 DOI: 10.1074/Jbc.M611599200  0.341
2007 Kaul M, Ma Q, Medders KE, Desai MK, Lipton SA. HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection. Cell Death and Differentiation. 14: 296-305. PMID 16841089 DOI: 10.1038/Sj.Cdd.4402006  0.333
2006 Barsoum MJ, Yuan H, Gerencser AA, Liot G, Kushnareva Y, Gräber S, Kovacs I, Lee WD, Waggoner J, Cui J, White AD, Bossy B, Martinou JC, Youle RJ, Lipton SA, et al. Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. The Embo Journal. 25: 3900-11. PMID 16874299 DOI: 10.1038/Sj.Emboj.7601253  0.327
2006 Wang Y, Eu J, Washburn M, Gong T, Chen HS, James WL, Lipton SA, Stamler JS, Went GT, Porter S. The pharmacology of aminoadamantane nitrates. Current Alzheimer Research. 3: 201-4. PMID 16842096 DOI: 10.2174/156720506777632808  0.318
2006 Kaul M, Lipton SA. Mechanisms of neuronal injury and death in HIV-1 associated dementia. Current Hiv Research. 4: 307-18. PMID 16842083 DOI: 10.2174/157016206777709384  0.307
2006 Uehara T, Nakamura T, Yao D, Shi ZQ, Gu Z, Ma Y, Masliah E, Nomura Y, Lipton SA. S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. Nature. 441: 513-7. PMID 16724068 DOI: 10.1038/Nature04782  0.305
2005 Han P, Dou F, Li F, Zhang X, Zhang YW, Zheng H, Lipton SA, Xu H, Liao FF. Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11542-52. PMID 16354912 DOI: 10.1523/Jneurosci.3831-05.2005  0.338
2005 Manabe S, Gu Z, Lipton SA. Activation of matrix metalloproteinase-9 via neuronal nitric oxide synthase contributes to NMDA-induced retinal ganglion cell death. Investigative Ophthalmology & Visual Science. 46: 4747-53. PMID 16303975 DOI: 10.1167/Iovs.05-0128  0.348
2005 Kaul M, Lipton SA. Experimental and potential future therapeutic approaches for HIV-1 associated dementia targeting receptors for chemokines, glutamate and erythropoietin. Neurotoxicity Research. 8: 167-86. PMID 16260394 DOI: 10.1007/Bf03033828  0.321
2005 Brody SA, Nakanishi N, Tu S, Lipton SA, Geyer MA. A developmental influence of the N-methyl-D-aspartate receptor NR3A subunit on prepulse inhibition of startle. Biological Psychiatry. 57: 1147-52. PMID 15866554 DOI: 10.1016/J.Biopsych.2005.01.024  0.314
2005 Kaul M, Zheng J, Okamoto S, Gendelman HE, Lipton SA. HIV-1 infection and AIDS: consequences for the central nervous system. Cell Death and Differentiation. 12: 878-92. PMID 15832177 DOI: 10.1038/Sj.Cdd.4401623  0.314
2004 Yao D, Gu Z, Nakamura T, Shi ZQ, Ma Y, Gaston B, Palmer LA, Rockenstein EM, Zhang Z, Masliah E, Uehara T, Lipton SA. Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity. Proceedings of the National Academy of Sciences of the United States of America. 101: 10810-4. PMID 15252205 DOI: 10.1073/Pnas.0404161101  0.311
2004 Digicaylioglu M, Garden G, Timberlake S, Fletcher L, Lipton SA. Acute neuroprotective synergy of erythropoietin and insulin-like growth factor I. Proceedings of the National Academy of Sciences of the United States of America. 101: 9855-60. PMID 15210945 DOI: 10.1073/pnas.0403172101  0.616
2004 Digicaylioglu M, Kaul M, Fletcher L, Dowen R, Lipton SA. Erythropoietin protects cerebrocortical neurons from HIV-1/gp120-induced damage. Neuroreport. 15: 761-3. PMID 15073510 DOI: 10.1097/00001756-200404090-00004  0.308
2004 Kaul M, Lipton SA. Signaling pathways to neuronal damage and apoptosis in human immunodeficiency virus type 1-associated dementia: Chemokine receptors, excitotoxicity, and beyond. Journal of Neurovirology. 10: 97-101. PMID 14982746 DOI: 10.1080/753312759  0.331
2004 Bossy-Wetzel E, Talantova MV, Lee WD, Schölzke MN, Harrop A, Mathews E, Götz T, Han J, Ellisman MH, Perkins GA, Lipton SA. Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels. Neuron. 41: 351-65. PMID 14766175 DOI: 10.1016/S0896-6273(04)00015-7  0.331
2003 Kermer P, Digicaylioglu MH, Kaul M, Zapata JM, Krajewska M, Stenner-Liewen F, Takayama S, Krajewski S, Lipton SA, Reed JC. BAG1 over-expression in brain protects against stroke. Brain Pathology (Zurich, Switzerland). 13: 495-506. PMID 14655755 DOI: 10.1111/J.1750-3639.2003.Tb00480.X  0.335
2002 Wong HK, Liu XB, Matos MF, Chan SF, Pérez-Otaño I, Boysen M, Cui J, Nakanishi N, Trimmer JS, Jones EG, Lipton SA, Sucher NJ. Temporal and regional expression of NMDA receptor subunit NR3A in the mammalian brain. The Journal of Comparative Neurology. 450: 303-17. PMID 12209845 DOI: 10.1002/cne.10314  0.308
2002 Gu Z, Kaul M, Yan B, Kridel SJ, Cui J, Strongin A, Smith JW, Liddington RC, Lipton SA. S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death. Science (New York, N.Y.). 297: 1186-90. PMID 12183632 DOI: 10.1126/Science.1073634  0.304
2002 Garden GA, Budd SL, Tsai E, Hanson L, Kaul M, D'Emilia DM, Friedlander RM, Yuan J, Masliah E, Lipton SA. Caspase cascades in human immunodeficiency virus-associated neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 4015-24. PMID 12019321 DOI: 10.1523/Jneurosci.22-10-04015.2002  0.647
2002 Okamoto S, Li Z, Ju C, Scholzke MN, Mathews E, Cui J, Salvesen GS, Bossy-Wetzel E, Lipton SA. Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 99: 3974-9. PMID 11904443 DOI: 10.1073/Pnas.022036399  0.357
2001 Kaul M, Garden GA, Lipton SA. Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature. 410: 988-94. PMID 11309629 DOI: 10.1038/35073667  0.65
1999 Kim WK, Choi YB, Rayudu PV, Das P, Asaad W, Arnelle DR, Stamler JS, Lipton SA. Attenuation of NMDA receptor activity and neurotoxicity by nitroxyl anion, NO-. Neuron. 24: 461-9. PMID 10571239 DOI: 10.1016/S0896-6273(00)80859-4  0.329
1999 Stieg PE, Sathi S, Warach S, Le DA, Lipton SA. Neuroprotection by the NMDA receptor-associated open-channel blocker memantine in a photothrombotic model of cerebral focal ischemia in neonatal rat. European Journal of Pharmacology. 375: 115-20. PMID 10443569 DOI: 10.1016/S0014-2999(99)00214-9  0.335
1999 Kaul M, Lipton SA. Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 96: 8212-6. PMID 10393974 DOI: 10.1073/pnas.96.14.8212  0.346
1998 Chen HS, Wang YF, Rayudu PV, Edgecomb P, Neill JC, Segal MM, Lipton SA, Jensen FE. Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation. Neuroscience. 86: 1121-32. PMID 9697119 DOI: 10.1016/S0306-4522(98)00163-8  0.557
1997 Lipton SA, Kim WK, Choi YB, Kumar S, D'Emilia DM, Rayudu PV, Arnelle DR, Stamler JS. Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor. Proceedings of the National Academy of Sciences of the United States of America. 94: 5923-8. PMID 9159176 DOI: 10.1073/Pnas.94.11.5923  0.323
1996 Pan ZH, Segal MM, Lipton SA. Nitric oxide-related species inhibit evoked neurotransmission but enhance spontaneous miniature synaptic currents in central neuronal cultures. Proceedings of the National Academy of Sciences of the United States of America. 93: 15423-8. PMID 8986827 DOI: 10.1073/Pnas.93.26.15423  0.56
1996 Dreyer EB, Zurakowski D, Schumer RA, Podos SM, Lipton SA. Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma. Archives of Ophthalmology (Chicago, Ill. : 1960). 114: 299-305. PMID 8600890 DOI: 10.1001/Archopht.1996.01100130295012  0.324
1995 Bading H, Segal MM, Sucher NJ, Dudek H, Lipton SA, Greenberg ME. N-methyl-D-aspartate receptors are critical for mediating the effects of glutamate on intracellular calcium concentration and immediate early gene expression in cultured hippocampal neurons. Neuroscience. 64: 653-64. PMID 7715778 DOI: 10.1016/0306-4522(94)00462-E  0.583
1995 Kater SB, Lipton SA. Neurotransmitter regulation of neuronal outgrowth, plasticity and survival in the year 2001. Trends in Neurosciences. 18: 71-2. PMID 7537415 DOI: 10.1016/0166-2236(95)80025-W  0.306
1994 Lipton SA, Singel DJ, Stamler JS. Nitric oxide in the central nervous system. Progress in Brain Research. 103: 359-64. PMID 7886218 DOI: 10.1016/S0079-6123(08)61149-8  0.34
1994 Lipton SA, Yeh M, Dreyer EB. Update on current models of HIV-related neuronal injury: platelet-activating factor, arachidonic acid and nitric oxide. Advances in Neuroimmunology. 4: 181-8. PMID 7874385 DOI: 10.1016/S0960-5428(06)80255-X  0.319
1994 Lipton SA, Stamler JS. Actions of redox-related congeners of nitric oxide at the NMDA receptor. Neuropharmacology. 33: 1229-33. PMID 7870283 DOI: 10.1016/0028-3908(94)90021-3  0.338
1994 Sullivan JM, Traynelis SF, Chen HS, Escobar W, Heinemann SF, Lipton SA. Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor. Neuron. 13: 929-36. PMID 7524561 DOI: 10.1016/0896-6273(94)90258-5  0.314
1993 Lipton SA, Choi YB, Pan ZH, Lei SZ, Chen HS, Sucher NJ, Loscalzo J, Singel DJ, Stamler JS. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature. 364: 626-32. PMID 8394509 DOI: 10.1038/364626A0  0.332
1991 Sucher NJ, Aizenman E, Lipton SA. N-methyl-D-aspartate antagonists prevent kainate neurotoxicity in rat retinal ganglion cells in vitro. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 11: 966-71. PMID 1672708 DOI: 10.1523/Jneurosci.11-04-00966.1991  0.555
1990 Aizenman E, Loring RH, Lipton SA. Blockade of nicotinic responses in rat retinal ganglion cells by neuronal bungarotoxin. Brain Research. 517: 209-14. PMID 2375991 DOI: 10.1016/0006-8993(90)91028-F  0.555
1989 Loring RH, Aizenman E, Lipton SA, Zigmond RE. Characterization of nicotinic receptors in chick retina using a snake venom neurotoxin that blocks neuronal nicotinic receptor function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 9: 2423-31. PMID 2746336 DOI: 10.1523/Jneurosci.09-07-02423.1989  0.555
1989 Aizenman E, Lipton SA, Loring RH. Selective modulation of NMDA responses by reduction and oxidation. Neuron. 2: 1257-63. PMID 2696504 DOI: 10.1016/0896-6273(89)90310-3  0.555
1989 Aizenman E, Karschin A, Lipton SA. Two pharmacological classes of quisqualate-induced electrical responses in rat retinal ganglion cells in vitro. European Journal of Pharmacology. 174: 9-22. PMID 2575535 DOI: 10.1016/0014-2999(89)90868-6  0.555
1989 Lipton SA, Kater SB. Neurotransmitter regulation of neuronal outgrowth, plasticity and survival. Trends in Neurosciences. 12: 265-70. PMID 2475939 DOI: 10.1016/0166-2236(89)90026-X  0.339
1988 Lipton SA, Frosch MP, Phillips MD, Tauck DL, Aizenman E. Nicotinic antagonists enhance process outgrowth by rat retinal ganglion cells in culture. Science (New York, N.Y.). 239: 1293-6. PMID 3344435 DOI: 10.1126/Science.3344435  0.555
1988 Hahn JS, Aizenman E, Lipton SA. Central mammalian neurons normally resistant to glutamate toxicity are made sensitive by elevated extracellular Ca2+: toxicity is blocked by the N-methyl-D-aspartate antagonist MK-801. Proceedings of the National Academy of Sciences of the United States of America. 85: 6556-60. PMID 2901101 DOI: 10.1073/Pnas.85.17.6556  0.555
1988 Aizenman E, Frosch MP, Lipton SA. Responses mediated by excitatory amino acid receptors in solitary retinal ganglion cells from rat. The Journal of Physiology. 396: 75-91. PMID 2842491 DOI: 10.1113/Jphysiol.1988.Sp016951  0.555
1988 Karschin A, Aizenman E, Lipton SA. The interaction of agonists and noncompetitive antagonists at the excitatory amino acid receptors in rat retinal ganglion cells in vitro. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 8: 2895-906. PMID 2842467 DOI: 10.1523/Jneurosci.08-08-02895.1988  0.555
1987 Lipton SA, Aizenman E, Loring RH. Neural nicotinic acetylcholine responses in solitary mammalian retinal ganglion cells. Pflã¼Gers Archiv : European Journal of Physiology. 410: 37-43. PMID 3684508 DOI: 10.1007/Bf00581893  0.555
1981 Lipton SA, Dowling JE. Chapter 21 The Relation between Ca2+ and Cyclic GMP in Rod Photoreceptors Current Topics in Membranes and Transport. 15: 381-392. DOI: 10.1016/S0070-2161(08)60512-2  0.396
1979 Lipton SA, Ostroy SE, Dowling JE. Ca2+ and photoreceptor adaptation. Nature. 281: 407-8. PMID 481607 DOI: 10.1038/281407c0  0.458
1977 Lipton SA, Ostroy SE, Dowling JE. Electrical and adaptive properties of rod photoreceptors in Bufo marinus. I. Effects of altered extracellular Ca2+ levels. The Journal of General Physiology. 70: 747-70. PMID 412914 DOI: 10.1085/Jgp.70.6.747  0.484
1977 Lipton SA, Rasmussen H, Dowling JE. Electrical and adaptive properties of rod photoreceptors in Bufo marinus. II. Effects of cyclic nucleotides and prostaglandins. The Journal of General Physiology. 70: 771-91. PMID 201724 DOI: 10.1085/Jgp.70.6.771  0.485
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