William C. Mobley - Publications

Affiliations: 
Neurology University of California, San Diego, La Jolla, CA 
Area:
neurodegneration, Down syndrome

172 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Chen XQ, Fang F, Florio JB, Rockenstein E, Masliah E, Mobley WC, Rissman RA, Wu C. TRiC enhances retrograde axonal transport by modulating tau phosphorylation. Traffic (Copenhagen, Denmark). PMID 30120810 DOI: 10.1111/tra.12610  0.48
2018 Sung K, Ferrari LF, Yang W, Chung C, Zhao X, Gu Y, Lin S, Zhang K, Cui B, Pearn ML, Maloney MT, Mobley WC, Levine JD, Wu C. Swedish Nerve Growth Factor Mutation (NGF) Defines a Role for TrkA and p75in Nociception. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29483280 DOI: 10.1523/JNEUROSCI.1686-17.2018  0.48
2017 Kleschevnikov AM, Yu J, Kim J, Lysenko LV, Zhen Z, Eugene Yu Y, Mobley WC. Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome. Neurobiology of Disease. PMID 28342823 DOI: 10.1016/j.nbd.2017.03.009  0.48
2016 Xing Z, Li Y, Pao A, Bennett AS, Tycko B, Mobley WC, Yu YE. Mouse-based genetic modeling and analysis of Down syndrome. British Medical Bulletin. PMID 27789459 DOI: 10.1093/bmb/ldw040  0.48
2016 Mojabi FS, Fahimi A, Moghadam S, Moghadam S, McNerneny MW, Ponnusamy R, Kleschevnikov A, Mobley WC, Salehi A. GABAergic Hyperinnervation of Dentate Granule Cells in the Ts65Dn Mouse Model of Down Syndrome Exploring the Role of App. Hippocampus. PMID 27701794 DOI: 10.1002/hipo.22664  1
2016 Zhao X, Chen XQ, Han E, Hu Y, Paik P, Ding Z, Overman J, Lau AL, Shahmoradian SH, Chiu W, Thompson LM, Wu C, Mobley WC. TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 27601642 DOI: 10.1073/pnas.1603020113  1
2016 Peiris H, Duffield MD, Fadista J, Jessup CF, Kashmir V, Genders AJ, McGee SL, Martin AM, Saiedi M, Morton N, Carter R, Cousin MA, Kokotos AC, Oskolkov N, Volkov P, ... ... Mobley WC, et al. A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes. Plos Genetics. 12: e1006033. PMID 27195491 DOI: 10.1371/journal.pgen.1006033  1
2016 Xu W, Weissmiller AM, White JA, Fang F, Wang X, Wu Y, Pearn ML, Zhao X, Sawa M, Chen S, Gunawardena S, Ding J, Mobley WC, Wu C. Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration. The Journal of Clinical Investigation. PMID 27064279 DOI: 10.1172/JCI82409  1
2016 Belichenko PV, Madani R, Rey-Bellet L, Pihlgren M, Becker A, Plassard A, Vuillermot S, Giriens V, Nosheny RL, Kleschevnikov AM, Valletta JS, Bengtsson SK, Linke GR, Maloney MT, Hickman DT, ... ... Mobley WC, et al. An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome. Plos One. 11: e0152471. PMID 27023444 DOI: 10.1371/journal.pone.0152471  1
2015 Jiang X, Liu C, Yu T, Zhang L, Meng K, Xing Z, Belichenko PV, Pao A, Peresie J, Wie S, Mobley WC, Yu YE. Genetic Dissection of the Down Syndrome Critical Region. Human Molecular Genetics. PMID 26374847 DOI: 10.1093/hmg/ddv364  1
2015 Zhao Y, Tseng IC, Heyser CJ, Rockenstein E, Mante M, Adame A, Zheng Q, Huang T, Wang X, Arslan PE, Chakrabarty P, Wu C, Bu G, Mobley WC, Zhang YW, et al. Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Neuron. 87: 963-75. PMID 26335643 DOI: 10.1016/j.neuron.2015.08.020  1
2015 Belichenko PV, Kleschevnikov AM, Becker A, Wagner GE, Lysenko LV, Yu YE, Mobley WC. Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues. Plos One. 10: e0134861. PMID 26230397 DOI: 10.1371/journal.pone.0134861  1
2015 Selfridge A, Hyun N, Chiang CC, Reyna SM, Weissmiller AM, Shi LZ, Preece D, Mobley WC, Berns MW. Rat embryonic hippocampus and induced pluripotent stem cell derived cultured neurons recover from laser-induced subaxotomy. Neurophotonics. 2: 015006. PMID 26157985 DOI: 10.1117/1.NPh.2.1.015006  0.48
2015 Nosheny RL, Belichenko PV, Busse BL, Weissmiller AM, Dang V, Das D, Fahimi A, Salehi A, Smith SJ, Mobley WC. Increased cortical synaptic activation of TrkB and downstream signaling markers in a mouse model of Down Syndrome. Neurobiology of Disease. 77: 173-90. PMID 25753471 DOI: 10.1016/j.nbd.2015.02.022  1
2015 Weissmiller AM, Natera-Naranjo O, Reyna SM, Pearn ML, Zhao X, Nguyen P, Cheng S, Goldstein LS, Tanzi RE, Wagner SL, Mobley WC, Wu C. A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. Plos One. 10: e0118379. PMID 25710492 DOI: 10.1371/journal.pone.0118379  1
2015 Hartley D, Blumenthal T, Carrillo M, DiPaolo G, Esralew L, Gardiner K, Granholm AC, Iqbal K, Krams M, Lemere C, Lott I, Mobley W, Ness S, Nixon R, Potter H, et al. Down syndrome and Alzheimer's disease: Common pathways, common goals. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 700-9. PMID 25510383 DOI: 10.1016/j.jalz.2014.10.007  1
2014 Fargo KN, Aisen P, Albert M, Au R, Corrada MM, DeKosky S, Drachman D, Fillit H, Gitlin L, Haas M, Herrup K, Kawas C, Khachaturian AS, Khachaturian ZS, ... ... Mobley W, et al. 2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: S430-52. PMID 25341459 DOI: 10.1016/j.jalz.2014.08.103  1
2014 Zhao X, Zhou Y, Weissmiller AM, Pearn ML, Mobley WC, Wu C. Real-time imaging of axonal transport of quantum dot-labeled BDNF in primary neurons. Journal of Visualized Experiments : Jove. 51899. PMID 25286194 DOI: 10.3791/51899  1
2014 Shahmoradian SH, Galiano MR, Wu C, Chen S, Rasband MN, Mobley WC, Chiu W. Preparation of primary neurons for visualizing neurites in a frozen-hydrated state using cryo-electron tomography. Journal of Visualized Experiments : Jove. e50783. PMID 24561719 DOI: 10.3791/50783  1
2014 Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE. Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species. Biochemistry. 53: 702-13. PMID 24401146 DOI: 10.1021/bi401537v  1
2014 Zhang L, Meng K, Jiang X, Liu C, Pao A, Belichenko PV, Kleschevnikov AM, Josselyn S, Liang P, Ye P, Mobley WC, Yu YE. Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits. Human Molecular Genetics. 23: 578-89. PMID 24041763 DOI: 10.1093/hmg/ddt446  1
2014 Ruparelia A, Mobley WC. Down Syndrome: A Model for Chromosome Abnormalities: A Model for Chromosome Abnormalities Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders. 59-77. DOI: 10.1016/B978-0-12-398270-4.00005-7  1
2014 Ruparelia A, Mobley WC. Introduction Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders. 15-17. DOI: 10.1016/B978-0-12-398270-4.00002-1  1
2013 Devor A, Bandettini PA, Boas DA, Bower JM, Buxton RB, Cohen LB, Dale AM, Einevoll GT, Fox PT, Franceschini MA, Friston KJ, Fujimoto JG, Geyer MA, Greenberg JH, Halgren E, ... ... Mobley WC, et al. The challenge of connecting the dots in the B.R.A.I.N. Neuron. 80: 270-4. PMID 24139032 DOI: 10.1016/j.neuron.2013.09.008  1
2013 Ruparelia A, Pearn ML, Mobley WC. Aging and intellectual disability: insights from mouse models of Down syndrome. Developmental Disabilities Research Reviews. 18: 43-50. PMID 23949828 DOI: 10.1002/ddrr.1127  1
2013 Trzoss L, Xu J, Lacoske MH, Mobley WC, Theodorakis EA. Illicium sesquiterpenes: divergent synthetic strategy and neurotrophic activity studies. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 6398-408. PMID 23526661 DOI: 10.1002/chem.201300198  1
2013 Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, et al. Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nature Medicine. 19: 473-80. PMID 23524343 DOI: 10.1038/nm.3117  1
2012 Wagner SL, Tanzi RE, Mobley WC, Galasko D. Potential use of γ-secretase modulators in the treatment of Alzheimer disease. Archives of Neurology. 69: 1255-8. PMID 22801784 DOI: 10.1001/archneurol.2012.540  1
2012 Kleschevnikov AM, Belichenko PV, Faizi M, Jacobs LF, Htun K, Shamloo M, Mobley WC. Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 9217-27. PMID 22764230 DOI: 10.1523/JNEUROSCI.1673-12.2012  1
2012 Ruparelia A, Pearn ML, Mobley WC. Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome. Current Opinion in Neurobiology. 22: 880-6. PMID 22658745 DOI: 10.1016/j.conb.2012.05.002  1
2012 Zhang L, Fu D, Belichenko PV, Liu C, Kleschevnikov AM, Pao A, Liang P, Clapcote SJ, Mobley WC, Yu YE. Genetic analysis of Down syndrome facilitated by mouse chromosome engineering. Bioengineered Bugs. 3: 8-12. PMID 22126738 DOI: 10.4161/bbug.3.1.17696  1
2012 Mobley W, Rosenberg RN. The evolution of academic neurology: New information will bring new meaning Archives of Neurology. 69: 308-314. PMID 22083800 DOI: 10.1001/archneurol.2011.1858  1
2012 Kleschevnikov AM, Belichenko PV, Gall J, George L, Nosheny R, Maloney MT, Salehi A, Mobley WC. Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome. Neurobiology of Disease. 45: 683-91. PMID 22062771 DOI: 10.1016/j.nbd.2011.10.009  1
2011 Liu C, Belichenko PV, Zhang L, Fu D, Kleschevnikov AM, Baldini A, Antonarakis SE, Mobley WC, Yu YE. Mouse models for Down syndrome-associated developmental cognitive disabilities. Developmental Neuroscience. 33: 404-13. PMID 21865664 DOI: 10.1159/000329422  1
2011 Trzoss L, Xu J, Lacoske MH, Mobley WC, Theodorakis EA. Enantioselective synthesis of (-)-jiadifenin, a potent neurotrophic modulator. Organic Letters. 13: 4554-7. PMID 21812392 DOI: 10.1021/ol201742j  1
2011 Faizi M, Bader PL, Tun C, Encarnacion A, Kleschevnikov A, Belichenko P, Saw N, Priestley M, Tsien RW, Mobley WC, Shamloo M. Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer. Neurobiology of Disease. 43: 397-413. PMID 21527343 DOI: 10.1016/j.nbd.2011.04.011  1
2011 Rissman RA, Mobley WC. Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease. Journal of Neurochemistry. 117: 613-22. PMID 21388375 DOI: 10.1111/j.1471-4159.2011.07237.x  1
2010 Yu T, Liu C, Belichenko P, Clapcote SJ, Li S, Pao A, Kleschevnikov A, Bechard AR, Asrar S, Chen R, Fan N, Zhou Z, Jia Z, Chen C, Roder JC, ... ... Mobley WC, et al. Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice. Brain Research. 1366: 162-71. PMID 20932954 DOI: 10.1016/j.brainres.2010.09.107  1
2010 Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, ... ... Mobley WC, et al. Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron. 67: 769-80. PMID 20826309 DOI: 10.1016/j.neuron.2010.08.018  1
2010 Yu T, Clapcote SJ, Li Z, Liu C, Pao A, Bechard AR, Carattini-Rivera S, Matsui S, Roder JC, Baldini A, Mobley WC, Bradley A, Yu YE. Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 21: 258-67. PMID 20512340 DOI: 10.1007/s00335-010-9262-x  1
2010 Shamloo M, Belichenko PV, Mobley WC. Comprehensive behavioral assays to enhance phenotype to genotype linkages and therapeutic screening in mouse models of down syndrome Future Neurology. 5: 467-471. DOI: 10.2217/fnl.10.29  1
2010 Wu C, Mobley WC. Retrograde Neurotrophic Signaling Encyclopedia of Neuroscience. 283-289. DOI: 10.1016/B978-008045046-9.00738-5  1
2009 Salehi A, Faizi M, Colas D, Valletta J, Laguna J, Takimoto-Kimura R, Kleschevnikov A, Wagner SL, Aisen P, Shamloo M, Mobley WC. Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome. Science Translational Medicine. 1: 7ra17. PMID 20368182 DOI: 10.1126/scitranslmed.3000258  1
2009 Tamaki SJ, Jacobs Y, Dohse M, Capela A, Cooper JD, Reitsma M, He D, Tushinski R, Belichenko PV, Salehi A, Mobley W, Gage FH, Huhn S, Tsukamoto AS, Weissman IL, et al. Neuroprotection of host cells by human central nervous system stem cells in a mouse model of infantile neuronal ceroid lipofuscinosis. Cell Stem Cell. 5: 310-9. PMID 19733542 DOI: 10.1016/j.stem.2009.05.022  1
2009 Mégarbané A, Ravel A, Mircher C, Sturtz F, Grattau Y, Rethoré MO, Delabar JM, Mobley WC. The 50th anniversary of the discovery of trisomy 21: the past, present, and future of research and treatment of Down syndrome. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 11: 611-6. PMID 19636252 DOI: 10.1097/GIM.0b013e3181b2e34c  1
2009 Belichenko NP, Belichenko PV, Kleschevnikov AM, Salehi A, Reeves RH, Mobley WC. The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 5938-48. PMID 19420260 DOI: 10.1523/JNEUROSCI.1547-09.2009  1
2009 Belichenko PV, Wright EE, Belichenko NP, Masliah E, Li HH, Mobley WC, Francke U. Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: evidence for disruption of neuronal networks. The Journal of Comparative Neurology. 514: 240-58. PMID 19296534 DOI: 10.1002/cne.22009  1
2009 Benedyk M, Berglund L, Facciotti M, Mobley W, Zucker D. Strategies for innovation and interdisciplinary translational research: Research and career benefits and barriers Journal of Investigative Medicine. 57: 477-481. PMID 19174698 DOI: 10.231/JIM.0b013e318198bcc2  1
2009 Belichenko NP, Belichenko PV, Mobley WC. Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation. Neurobiology of Disease. 34: 71-7. PMID 19167498 DOI: 10.1016/j.nbd.2008.12.016  1
2009 Belichenko PV, Kleschevnikov AM, Masliah E, Wu C, Takimoto-Kimura R, Salehi A, Mobley WC. Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome. The Journal of Comparative Neurology. 512: 453-66. PMID 19034952 DOI: 10.1002/cne.21895  1
2009 Wu C, Cui B, He L, Chen L, Mobley WC. The coming of age of axonal neurotrophin signaling endosomes. Journal of Proteomics. 72: 46-55. PMID 19028611 DOI: 10.1016/j.jprot.2008.10.007  1
2008 Wan J, Cheung AY, Fu WY, Wu C, Zhang M, Mobley WC, Cheung ZH, Ip NY. Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 9002-12. PMID 18768694 DOI: 10.1523/JNEUROSCI.0767-08.2008  1
2008 Eaton DL, Daroff RB, Autrup H, Bridges J, Buffler P, Costa LG, Coyle J, McKhann G, Mobley WC, Nadel L, Neubert D, Schulte-Hermann R, Spencer PS. Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment. Critical Reviews in Toxicology. 38: 1-125. PMID 18726789 DOI: 10.1080/10408440802272158  1
2008 Belichenko NP, Belichenko PV, Li HH, Mobley WC, Francke U. Comparative study of brain morphology in Mecp2 mutant mouse models of Rett syndrome. The Journal of Comparative Neurology. 508: 184-95. PMID 18306326 DOI: 10.1002/cne.21673  1
2008 Colas D, Valletta JS, Takimoto-Kimura R, Nishino S, Fujiki N, Mobley WC, Mignot E. Sleep and EEG features in genetic models of Down syndrome. Neurobiology of Disease. 30: 1-7. PMID 18282758 DOI: 10.1016/j.nbd.2007.07.014  1
2008 Chial HJ, Wu R, Ustach CV, McPhail LC, Mobley WC, Chen YQ. Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides. Traffic (Copenhagen, Denmark). 9: 215-29. PMID 18034774 DOI: 10.1111/j.1600-0854.2007.00680.x  1
2007 Salehi A, Faizi M, Belichenko PV, Mobley WC. Using mouse models to explore genotype-phenotype relationship in Down syndrome. Mental Retardation and Developmental Disabilities Research Reviews. 13: 207-14. PMID 17910089 DOI: 10.1002/mrdd.20164  1
2007 Wu C, Ramirez A, Cui B, Ding J, Delcroix JD, Valletta JS, Liu JJ, Yang Y, Chu S, Mobley WC. A functional dynein-microtubule network is required for NGF signaling through the Rap1/MAPK pathway. Traffic (Copenhagen, Denmark). 8: 1503-20. PMID 17822405 DOI: 10.1111/j.1600-0854.2007.00636.x  1
2007 Cui B, Wu C, Chen L, Ramirez A, Bearer EL, Li WP, Mobley WC, Chu S. One at a time, live tracking of NGF axonal transport using quantum dots. Proceedings of the National Academy of Sciences of the United States of America. 104: 13666-71. PMID 17698956 DOI: 10.1073/pnas.0706192104  1
2007 Belichenko PV, Kleschevnikov AM, Salehi A, Epstein CJ, Mobley WC. Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships. The Journal of Comparative Neurology. 504: 329-45. PMID 17663443 DOI: 10.1002/cne.21433  1
2007 Liu JJ, Ding J, Wu C, Bhagavatula P, Cui B, Chu S, Mobley WC, Yang Y. Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport. Proceedings of the National Academy of Sciences of the United States of America. 104: 2223-8. PMID 17287360 DOI: 10.1073/pnas.0602222104  1
2007 Salehi A, Kleshevnikov A, Mobley WC. Cholinergic neurodegeneration in Alzheimer's disease: Basis for nerve growth factor therapy Pharmacological Mechanisms in Alzheimer's Therapeutics. 64-104. DOI: 10.1007/978-0-387-71522-3_5  1
2006 Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, ... ... Mobley WC, et al. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 51: 29-42. PMID 16815330 DOI: 10.1016/j.neuron.2006.05.022  1
2006 Miyamoto Y, Yamauchi J, Tanoue A, Wu C, Mobley WC. TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology. Proceedings of the National Academy of Sciences of the United States of America. 103: 10444-9. PMID 16801538 DOI: 10.1073/pnas.0603914103  1
2006 Ding J, Allen E, Wang W, Valle A, Wu C, Nardine T, Cui B, Yi J, Taylor A, Jeon NL, Chu S, So Y, Vogel H, Tolwani R, Mobley W, et al. Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport. Human Molecular Genetics. 15: 1451-63. PMID 16565160 DOI: 10.1093/hmg/ddl069  1
2006 Watson G, Bastacky J, Belichenko P, Buddhikot M, Jungles S, Vellard M, Mobley WC, Kakkis E. Intrathecal administration of AAV vectors for the treatment of lysosomal storage in the brains of MPS I mice. Gene Therapy. 13: 917-25. PMID 16482204 DOI: 10.1038/sj.gt.3302735  1
2005 Belichenko PV, Dickson PI, Passage M, Jungles S, Mobley WC, Kakkis ED. Penetration, diffusion, and uptake of recombinant human alpha-L-iduronidase after intraventricular injection into the rat brain. Molecular Genetics and Metabolism. 86: 141-9. PMID 16006167 DOI: 10.1016/j.ymgme.2005.04.013  1
2005 Greenberg JO, Rizzo M, Mobley WC. An AUPN/ANA survey of department leader opinions on the health of US academic neurology [1] (multiple letters) Neurology. 64: 1664. PMID 15883349  1
2005 Villar AJ, Belichenko PV, Gillespie AM, Kozy HM, Mobley WC, Epstein CJ. Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 16: 79-90. PMID 15859352 DOI: 10.1007/s00335-004-2428-7  1
2005 Howe CL, Mobley WC. Long-distance retrograde neurotrophic signaling. Current Opinion in Neurobiology. 15: 40-8. PMID 15721743 DOI: 10.1016/j.conb.2005.01.010  1
2005 Gardiner K, Davisson MT, Pritchard M, Patterson D, Groner Y, Crnic LS, Antonarakis S, Mobley W. Report on the 'Expert Workshop on the Biology of Chromosome 21: Towards gene-phenotype correlations in Down syndrome', held June 11-14, 2004, Washington D.C Cytogenetic and Genome Research. 108: 269-277. PMID 15627744 DOI: 10.1159/000081518  1
2004 Belichenko PV, Masliah E, Kleschevnikov AM, Villar AJ, Epstein CJ, Salehi A, Mobley WC. Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome. The Journal of Comparative Neurology. 480: 281-98. PMID 15515178 DOI: 10.1002/cne.20337  1
2004 Rizzo M, Mobley WC. An AUPN/ANA survey of department leader opinions on the health of US academic neurology. Neurology. 63: 1354-6. PMID 15505148  1
2004 Kakkis E, McEntee M, Vogler C, Le S, Levy B, Belichenko P, Mobley W, Dickson P, Hanson S, Passage M. Intrathecal enzyme replacement therapy reduces lysosomal storage in the brain and meninges of the canine model of MPS I Molecular Genetics and Metabolism. 83: 163-174. PMID 15464431 DOI: 10.1016/j.ymgme.2004.07.003  1
2004 Pontikis CC, Cella CV, Parihar N, Lim MJ, Chakrabarti S, Mitchison HM, Mobley WC, Rezaie P, Pearce DA, Cooper JD. Late onset neurodegeneration in the Cln3-/- mouse model of juvenile neuronal ceroid lipofuscinosis is preceded by low level glial activation. Brain Research. 1023: 231-42. PMID 15374749 DOI: 10.1016/j.brainres.2004.07.030  1
2004 Kleschevnikov AM, Belichenko PV, Villar AJ, Epstein CJ, Malenka RC, Mobley WC. Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 8153-60. PMID 15371516 DOI: 10.1523/JNEUROSCI.1766-04.2004  1
2004 Reichardt LF, Mobley WC. Going the distance, or not, with neurotrophin signals. Cell. 118: 141-3. PMID 15260984 DOI: 10.1016/j.cell.2004.07.008  1
2004 Howe CL, Mobley WC. Signaling endosome hypothesis: A cellular mechanism for long distance communication. Journal of Neurobiology. 58: 207-16. PMID 14704953 DOI: 10.1002/neu.10323  1
2004 Delcroix JD, Valletta J, Wu C, Howe CL, Lai CF, Cooper JD, Belichenko PV, Salehi A, Mobley WC. Trafficking the NGF signal: implications for normal and degenerating neurons. Progress in Brain Research. 146: 3-23. PMID 14699953  1
2003 Liu JJ, Ding J, Kowal AS, Nardine T, Allen E, Delcroix JD, Wu C, Mobley W, Fuchs E, Yang Y. BPAG1n4 is essential for retrograde axonal transport in sensory neurons. The Journal of Cell Biology. 163: 223-9. PMID 14581450 DOI: 10.1083/jcb.200306075  1
2003 Delcroix JD, Valletta JS, Wu C, Hunt SJ, Kowal AS, Mobley WC. NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals. Neuron. 39: 69-84. PMID 12848933 DOI: 10.1016/S0896-6273(03)00397-0  1
2003 Salehi A, Delcroix JD, Mobley WC. Traffic at the intersection of neurotrophic factor signaling and neurodegeneration. Trends in Neurosciences. 26: 73-80. PMID 12536130 DOI: 10.1016/S0166-2236(02)00038-3  1
2001 Howe CL, Valletta JS, Rusnak AS, Mobley WC. NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway. Neuron. 32: 801-14. PMID 11738027 DOI: 10.1016/S0896-6273(01)00526-8  1
2001 Sofroniew MV, Howe CL, Mobley WC. Nerve growth factor signaling, neuroprotection, and neural repair. Annual Review of Neuroscience. 24: 1217-81. PMID 11520933 DOI: 10.1146/annurev.neuro.24.1.1217  1
2001 Cooper JD, Salehi A, Delcroix JD, Howe CL, Belichenko PV, Chua-Couzens J, Kilbridge JF, Carlson EJ, Epstein CJ, Mobley WC. Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion. Proceedings of the National Academy of Sciences of the United States of America. 98: 10439-44. PMID 11504920 DOI: 10.1073/pnas.181219298  1
2001 Wu C, Lai CF, Mobley WC. Nerve growth factor activates persistent Rap1 signaling in endosomes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 5406-16. PMID 11466412  1
2001 Cooper JD, Mobley WC. Neurotrophic factors as potential therapeutic agents in neuronal ceroid lipofuscinosis. Advances in Genetics. 45: 169-82. PMID 11332772  1
2001 Mischel PS, Smith SG, Vining ER, Valletta JS, Mobley WC, Reichardt LF. The extracellular domain of p75NTR is necessary to inhibit neurotrophin-3 signaling through TrkA. The Journal of Biological Chemistry. 276: 11294-301. PMID 11150291 DOI: 10.1074/jbc.M005132200  1
2000 Lynch C, Mobley W. Comprehensive theory of Alzheimer's disease. The effects of cholesterol on membrane receptor trafficking Annals of the New York Academy of Sciences. 924: 104-111. PMID 11193786  1
2000 Beattie EC, Howe CL, Wilde A, Brodsky FM, Mobley WC. NGF signals through TrkA to increase clathrin at the plasma membrane and enhance clathrin-mediated membrane trafficking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 7325-33. PMID 11007890  1
2000 Villoslada P, Hauser SL, Bartke I, Unger J, Heald N, Rosenberg D, Cheung SW, Mobley WC, Fisher S, Genain CP. Human nerve growth factor protects common marmosets against autoimmune encephalomyelitis by switching the balance of T helper cell type 1 and 2 cytokines within the central nervous system. The Journal of Experimental Medicine. 191: 1799-806. PMID 10811872 DOI: 10.1084/jem.191.10.1799  1
1999 Huang CS, Zhou J, Feng AK, Lynch CC, Klumperman J, DeArmond SJ, Mobley WC. Nerve growth factor signaling in caveolae-like domains at the plasma membrane. The Journal of Biological Chemistry. 274: 36707-14. PMID 10593976 DOI: 10.1074/jbc.274.51.36707  1
1999 Mitchison HM, Bernard DJ, Greene ND, Cooper JD, Junaid MA, Pullarkat RK, de Vos N, Breuning MH, Owens JW, Mobley WC, Gardiner RM, Lake BD, Taschner PE, Nussbaum RL. Targeted disruption of the Cln3 gene provides a mouse model for Batten disease. The Batten Mouse Model Consortium [corrected]. Neurobiology of Disease. 6: 321-34. PMID 10527801 DOI: 10.1006/nbdi.1999.0267  1
1999 Yuen EC, Mobley WC. Early BDNF, NT-3, and NT-4 signaling events. Experimental Neurology. 159: 297-308. PMID 10486198 DOI: 10.1006/exnr.1999.7148  1
1999 Wilde A, Beattie EC, Lem L, Riethof DA, Liu SH, Mobley WC, Soriano P, Brodsky FM. EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake. Cell. 96: 677-87. PMID 10089883  1
1999 Cooper JD, Messer A, Feng AK, Chua-Couzens J, Mobley WC. Apparent loss and hypertrophy of interneurons in a mouse model of neuronal ceroid lipofuscinosis: evidence for partial response to insulin-like growth factor-1 treatment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 2556-67. PMID 10087069  1
1998 Butte MJ, Hwang PK, Mobley WC, Fletterick RJ. Crystal structure of neurotrophin-3 homodimer shows distinct regions are used to bind its receptors. Biochemistry. 37: 16846-52. PMID 9836577 DOI: 10.1021/bi981254o  1
1998 Tremblay P, Meiner Z, Galou M, Heinrich C, Petromilli C, Lisse T, Cayetano J, Torchia M, Mobley W, Bujard H, DeArmond SJ, Prusiner SB. Doxycycline control of prion protein transgene expression modulates prion disease in mice. Proceedings of the National Academy of Sciences of the United States of America. 95: 12580-5. PMID 9770528 DOI: 10.1073/pnas.95.21.12580  1
1998 Fagan AM, Murphy BA, Patel SN, Kilbridge JF, Mobley WC, Bu G, Holtzman DM. Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury. Experimental Neurology. 151: 314-25. PMID 9628766 DOI: 10.1006/exnr.1998.6818  1
1998 Sago H, Carlson EJ, Smith DJ, Kilbridge J, Rubin EM, Mobley WC, Epstein CJ, Huang TT. Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities. Proceedings of the National Academy of Sciences of the United States of America. 95: 6256-61. PMID 9600952 DOI: 10.1073/pnas.95.11.6256  1
1998 DeArmond SJ, Mobley WC, DeMott DL, Barry RA, Beckstead JH, Prusiner SB. Changes in the localization of brain prion proteins during scrapie infection. Neurology. 50: 1271-80; discussion . PMID 9443448  1
1997 Schätzl HM, Laszlo L, Holtzman DM, Tatzelt J, DeArmond SJ, Weiner RI, Mobley WC, Prusiner SB. A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis. Journal of Virology. 71: 8821-31. PMID 9343242  1
1997 Yeo TT, Chua-Couzens J, Butcher LL, Bredesen DE, Cooper JD, Valletta JS, Mobley WC, Longo FM. Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 7594-605. PMID 9315882  1
1997 Grimes ML, Beattie E, Mobley WC. A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA. Proceedings of the National Academy of Sciences of the United States of America. 94: 9909-14. PMID 9275225 DOI: 10.1073/pnas.94.18.9909  1
1996 Longo FM, Mobley WC. Minimized hormones grow in stature. Nature Biotechnology. 14: 1092. PMID 9631056 DOI: 10.1038/nbt0996-1092  1
1996 DeArmond SJ, Qiu Y, Wong K, Nixon R, Hyun W, Prusiner SB, Mobley WC. Abnormal plasma membrane properties and functions in prion-infected cell lines. Cold Spring Harbor Symposia On Quantitative Biology. 61: 531-40. PMID 9246479  1
1996 Beattie EC, Zhou J, Grimes ML, Bunnett NW, Howe CL, Mobley WC. A signaling endosome hypothesis to explain NGF actions: potential implications for neurodegeneration. Cold Spring Harbor Symposia On Quantitative Biology. 61: 389-406. PMID 9246468  1
1996 Grimes ML, Zhou J, Beattie EC, Yuen EC, Hall DE, Valletta JS, Topp KS, LaVail JH, Bunnett NW, Mobley WC. Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 7950-64. PMID 8987823  1
1996 Holtzman DM, Santucci D, Kilbridge J, Chua-Couzens J, Fontana DJ, Daniels SE, Johnson RM, Chen K, Sun Y, Carlson E, Alleva E, Epstein CJ, Mobley WC. Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome. Proceedings of the National Academy of Sciences of the United States of America. 93: 13333-8. PMID 8917591 DOI: 10.1073/pnas.93.23.13333  1
1996 Yuen EC, Howe CL, Li Y, Holtzman DM, Mobley WC. Nerve growth factor and the neurotrophic factor hypothesis. Brain & Development. 18: 362-8. PMID 8891230 DOI: 10.1016/0387-7604(96)00051-4  1
1996 Holtzman DM, Lee S, Li Y, Chua-Couzens J, Xia H, Bredt DS, Mobley WC. Expression of neuronal-NOS in developing basal forebrain cholinergic neurons: regulation by NGF. Neurochemical Research. 21: 861-8. PMID 8873091  1
1996 Neve RL, Valletta JS, Li Y, Ventosa-Michelman M, Holtzman DM, Mobley WC. A comprehensive study of the spatiotemporal pattern of beta-amyloid precursor protein mRNA and protein in the rat brain: lack of modulation by exogenously applied nerve growth factor. Brain Research. Molecular Brain Research. 39: 185-97. PMID 8804727 DOI: 10.1016/0169-328X(96)00007-1  1
1996 Yuen EC, Mobley WC. Therapeutic potential of neurotrophic factors for neurological disorders. Annals of Neurology. 40: 346-54. PMID 8797524 DOI: 10.1002/ana.410400304  1
1996 Mobley WC. Recent progress in developmental neurology: exploring the bench to bedside interface. Current Opinion in Neurology. 9: 107-112. PMID 8782977  1
1996 Holtzman DM, Epstein CJ, Mobley WC. The human trisomy 21 brain: Insights from mouse models of Down syndrome Mental Retardation and Developmental Disabilities Research Reviews. 2: 66-72.  1
1995 Yuen EC, Mobley WC. Therapeutic applications of neurotrophic factors in disorders of motor neurons and peripheral nerves. Molecular Medicine Today. 1: 278-86. PMID 9415162  1
1995 Holtzman DM, Kilbridge J, Chen KS, Rabin J, Luche R, Carlson E, Epstein CJ, Mobley WC. Preliminary characterization of the central nervous system in partial trisomy 16 mice. Progress in Clinical and Biological Research. 393: 227-40. PMID 8545453  1
1995 Holtzman DM, Kilbridge J, Li Y, Cunningham ET, Lenn NJ, Clary DO, Reichardt LF, Mobley WC. TrkA expression in the CNS: evidence for the existence of several novel NGF-responsive CNS neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 1567-76. PMID 7869118  1
1995 Zhou J, Valletta JS, Grimes ML, Mobley WC. Multiple levels for regulation of TrkA in PC12 cells by nerve growth factor. Journal of Neurochemistry. 65: 1146-56. PMID 7543930  1
1995 Li Y, Holtzman DM, Kromer LF, Kaplan DR, Chua-Couzens J, Clary DO, Knüsel B, Mobley WC. Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 2888-905. PMID 7536822  1
1994 Holtzman DM, Kilbridge J, Bredt DS, Black SM, Li Y, Clary DO, Reichardt LF, Mobley WC. NOS induction by NGF in basal forebrain cholinergic neurones: evidence for regulation of brain NOS by a neurotrophin. Neurobiology of Disease. 1: 51-60. PMID 9216986 DOI: 10.1006/nbdi.1994.0007  1
1994 Zhou J, Holtzman DM, Weiner RI, Mobley WC. Expression of TrkA confers neuron-like responsiveness to nerve growth factor on an immortalized hypothalamic cell line. Proceedings of the National Academy of Sciences of the United States of America. 91: 3824-8. PMID 8170995  1
1994 Chen CK, Kinsman SL, Holtzman DM, Mobley WC, Johnston MV. A reverse transcription-polymerase chain reaction study of p75 nerve growth factor receptor gene expression in developing rat cerebellum. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 12: 255-62. PMID 7976482 DOI: 10.1016/0736-5748(94)90072-8  1
1994 Holtzman DM, Mobley WC. Neurotrophic factors and neurologic disease. The Western Journal of Medicine. 161: 246-54. PMID 7975562  1
1994 Burke MA, Mobley WC, Cho J, Wiegand SJ, Lindsay RM, Mufson EJ, Kordower JH. Loss of developing cholinergic basal forebrain neurons following excitotoxic lesions of the hippocampus: rescue by neurotrophins. Experimental Neurology. 130: 178-95. PMID 7867749 DOI: 10.1006/exnr.1994.1197  1
1994 Higgins LS, Holtzman DM, Rabin J, Mobley WC, Cordell B. Transgenic mouse brain histopathology resembles early Alzheimer's disease. Annals of Neurology. 35: 598-607. PMID 7513982 DOI: 10.1002/ana.410350514  1
1993 Holtzman DM, Li Y, Chen K, Gage FH, Epstein CJ, Mobley WC. Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration. Neurology. 43: 2668-73. PMID 8255474  1
1993 Sofroniew MV, Mobley WC. On the possibility of positive-feedback in trophic interactions between afferent and target neurons Seminars in Neuroscience. 5: 309-312. DOI: 10.1016/S1044-5765(05)80036-3  1
1993 Grimes M, Zhou J, Li Y, Holtzman D, Mobley WC. Neurotrophin signalling in the nervous system Seminars in Neuroscience. 5: 239-247. DOI: 10.1016/S1044-5765(05)80029-6  1
1992 Holtzman DM, Li YW, DeArmond SJ, McKinley MP, Gage FH, Epstein CJ, Mobley WC. Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants. Proceedings of the National Academy of Sciences of the United States of America. 89: 1383-7. PMID 1741393  1
1992 Holtzman DM, Li Y, Parada LF, Kinsman S, Chen CK, Valletta JS, Zhou J, Long JB, Mobley WC. p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF. Neuron. 9: 465-78. PMID 1524827 DOI: 10.1016/0896-6273(92)90184-F  1
1992 Holtzman DM, Li Y, Gage FH, Epstein CJ, Mobley WC. Neurodegeneration and gene dysregulation: studies utilizing the mouse trisomy 16 model of Down syndrome. Progress in Clinical and Biological Research. 379: 227-44. PMID 1409747  1
1992 Holtzman DM, Bayney RM, Li YW, Khosrovi H, Berger CN, Epstein CJ, Mobley WC. Dysregulation of gene expression in mouse trisomy 16, an animal model of Down syndrome. The Embo Journal. 11: 619-27. PMID 1371464  1
1991 Koliatsos VE, Applegate MD, Knüsel B, Junard EO, Burton LE, Mobley WC, Hefti FF, Price DL. Recombinant human nerve growth factor prevents retrograde degeneration of axotomized basal forebrain cholinergic neurons in the rat. Experimental Neurology. 112: 161-73. PMID 2037030 DOI: 10.1016/0014-4886(91)90066-L  1
1991 Fahnestock M, Woo JE, Lopez GA, Snow J, Walz DA, Arici MJ, Mobley WC. beta-NGF-endopeptidase: structure and activity of a kallikrein encoded by the gene mGK-22. Biochemistry. 30: 3443-50. PMID 2012805  1
1991 Gold BG, Mobley WC, Matheson SF. Regulation of axonal caliber, neurofilament content, and nuclear localization in mature sensory neurons by nerve growth factor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 11: 943-55. PMID 2010817  1
1991 Holtzman DM, Mobley WC. Molecular studies in Alzheimer's disease. Trends in Biochemical Sciences. 16: 140-4. PMID 1877089 DOI: 10.1016/0968-0004(91)90056-2  1
1991 Koliatsos VE, Shelton DL, Mobley WC, Price DL. A novel group of nerve growth factor receptor-immunoreactive neurons in the ventral horn of the lumbar spinal cord. Brain Research. 541: 121-8. PMID 1851446 DOI: 10.1016/0006-8993(91)91084-E  1
1991 Holtzman DM, Li YW, Gage FH, DeArmond SJ, Epstein CJ, McKinley MP, Mobley WC. Modeling cholinergic abnormalities in Down syndrome and Alzheimer's disease. Progress in Clinical and Biological Research. 373: 189-202. PMID 1838184  1
1991 Koliatsos VE, Clatterbuck RE, Nauta HJ, Knüsel B, Burton LE, Hefti FF, Mobley WC, Price DL. Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates. Annals of Neurology. 30: 831-40. PMID 1789695 DOI: 10.1002/ana.410300613  1
1991 Taiwo YO, Levine JD, Burch RM, Woo JE, Mobley WC. Hyperalgesia induced in the rat by the amino-terminal octapeptide of nerve growth factor. Proceedings of the National Academy of Sciences of the United States of America. 88: 5144-8. PMID 1647026 DOI: 10.1073/pnas.88.12.5144  1
1990 Koliatsos VE, Nauta HJ, Clatterbuck RE, Holtzman DM, Mobley WC, Price DL. Mouse nerve growth factor prevents degeneration of axotomized basal forebrain cholinergic neurons in the monkey. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 3801-13. PMID 2269884  1
1990 Knüsel B, Burton LE, Longo FM, Mobley WC, Koliatsos VE, Price DL, Hefti F. Trophic actions of recombinant human nerve growth factor on cultured rat embryonic CNS cells. Experimental Neurology. 110: 274-83. PMID 2249737 DOI: 10.1016/0014-4886(90)90039-U  1
1990 Burgin KE, Waxham MN, Rickling S, Westgate SA, Mobley WC, Kelly PT. In situ hybridization histochemistry of Ca2+/calmodulin-dependent protein kinase in developing rat brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 1788-98. PMID 2162385  1
1990 Sinha S, Dovey HF, Seubert P, Ward PJ, Blacher RW, Blaber M, Bradshaw RA, Arici M, Mobley WC, Lieberburg I. The protease inhibitory properties of the Alzheimer's beta-amyloid precursor protein. The Journal of Biological Chemistry. 265: 8983-5. PMID 2111813  1
1990 Longo FM, Vu TK, Mobley WC. The in vitro biological effect of nerve growth factor is inhibited by synthetic peptides. Cell Regulation. 1: 189-95. PMID 2100197  1
1990 McKinley MP, Longo FM, Valletta JS, Rahbar F, Neve RL, Prusiner SB, Mobley WC. Nerve growth factor induces gene expression of the prion protein and beta-amyloid protein precursor in the developing hamster central nervous system. Progress in Brain Research. 86: 227-38. PMID 1982367  1
1989 Mobley WC. Nerve growth factor in Alzheimer's disease: to treat or not to treat? Neurobiology of Aging. 10: 578-80; discussion 5. PMID 2812231 DOI: 10.1016/0197-4580(89)90135-8  1
1989 Saffran BN, Woo JE, Mobley WC, Crutcher KA. Intraventricular NGF infusion in the mature rat brain enhances sympathetic innervation of cerebrovascular targets but fails to elicit sympathetic ingrowth. Brain Research. 492: 245-54. PMID 2752299 DOI: 10.1016/0006-8993(89)90907-4  1
1989 Hsiang J, Heller A, Hoffmann PC, Mobley WC, Wainer BH. The effects of nerve growth factor on the development of septal cholinergic neurons in reaggregate cell cultures. Neuroscience. 29: 209-23. PMID 2710345 DOI: 10.1016/0306-4522(89)90344-8  1
1989 Phelps CH, Gage FH, Growdon JH, Hefti F, Harbaugh R, Johnston MV, Khachaturian ZS, Mobley WC, Price DL, Raskind M. Potential use of nerve growth factor to treat Alzheimer's disease. Neurobiology of Aging. 10: 205-7. PMID 2657468 DOI: 10.1016/0197-4580(89)90032-8  1
1989 De Armond SJ, Gonzales M, Mobley WC, Kon AA, Stern A, Prusiner H, Prusiner SB. PrPSc in scrapie-infected hamster brain is spatially and temporally related to histopathology and infectivity titer. Progress in Clinical and Biological Research. 317: 601-18. PMID 2574872  1
1989 Mobley WC, Woo JE, Edwards RH, Riopelle RJ, Longo FM, Weskamp G, Otten U, Valletta JS, Johnston MV. Developmental regulation of nerve growth factor and its receptor in the rat caudate-putamen. Neuron. 3: 655-64. PMID 2561975 DOI: 10.1016/0896-6273(89)90276-6  1
1989 McKinley MP, DeArmond SJ, Torchia M, Mobley WC, Prusiner SB. Acceleration of scrapie in neonatal Syrian hamsters. Neurology. 39: 1319-24. PMID 2507957  1
1989 Sharp FR, Gonzalez MF, Hisanaga K, Mobley WC, Sagar SM. Induction of the c-fos gene product in rat forebrain following cortical lesions and NGF injections. Neuroscience Letters. 100: 117-22. PMID 2503789 DOI: 10.1016/0304-3940(89)90670-8  1
1988 Edwards RH, Selby MJ, Mobley WC, Weinrich SL, Hruby DE, Rutter WJ. Processing and secretion of nerve growth factor: expression in mammalian cells with a vaccinia virus vector. Molecular and Cellular Biology. 8: 2456-64. PMID 3405211  1
1988 Mobley WC, Neve RL, Prusiner SB, McKinley MP. Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain. Proceedings of the National Academy of Sciences of the United States of America. 85: 9811-5. PMID 2904679  1
1988 Long JB, Petras JM, Mobley WC, Holaday JW. Neurological dysfunction after intrathecal injection of dynorphin A (1-13) in the rat. II. Nonopioid mechanisms mediate loss of motor, sensory and autonomic function. The Journal of Pharmacology and Experimental Therapeutics. 246: 1167-74. PMID 2901487  1
1988 Long JB, Mobley WC, Holaday JW. Neurological dysfunction after intrathecal injection of dynorphin A (1-13) in the rat. I. Injection procedures modify pharmacological responses. The Journal of Pharmacology and Experimental Therapeutics. 246: 1158-66. PMID 2901486  1
1987 Johnston MV, Rutkowski JL, Wainer BH, Long JB, Mobley WC. NGF effects on developing forebrain cholinergic neurons are regionally specific. Neurochemical Research. 12: 985-94. PMID 3683745 DOI: 10.1007/BF00970927  1
1987 DeArmond SJ, Mobley WC, DeMott DL, Barry RA, Beckstead JH, Prusiner SB. Changes in the localization of brain prion proteins during scrapie infection. Neurology. 37: 1271-80. PMID 3112607  1
1986 Mobley WC, Rutkowski JL, Tennekoon GI, Gemski J, Buchanan K, Johnston MV. Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons. Brain Research. 387: 53-62. PMID 3742234 DOI: 10.1016/0169-328X(86)90020-3  1
1985 Kitt CA, Struble RG, Cork LC, Mobley WC, Walker LC, Joh TH, Price DL. Catecholaminergic neurites in senile plaques in prefrontal cortex of aged nonhuman primates. Neuroscience. 16: 691-9. PMID 2869445 DOI: 10.1016/0306-4522(85)90202-7  1
1985 Mobley WC, Rutkowski JL, Tennekoon GI, Buchanan K, Johnston MV. Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor. Science (New York, N.Y.). 229: 284-7. PMID 2861660  1
1984 Kitt CA, Price DL, Struble RG, Cork LC, Wainer BH, Becher MW, Mobley WC. Evidence for cholinergic neurites in senile plaques. Science (New York, N.Y.). 226: 1443-5. PMID 6505701  1
1982 Mobley WC, Wolinsky JS. Scientific overview of inflammatory demyelinating polyneuropathy and design of the North American collaborative study of plasma exchange in Guillain-Barre syndrome. Progress in Clinical and Biological Research. 106: 159-87. PMID 6757937  1
1978 Shapira R, Mobley WC, Thiele SB, Wilhelmi MR, Wallace A, Kibler RF. Localization of 2',3'-cyclic nucleotide-3'-phosphohydrolase of rabbit brain by sedimentation in a continuous sucrose gradient. Journal of Neurochemistry. 30: 735-44. PMID 206668 DOI: 10.1111/j.1471-4159.1978.tb10779.x  1
1977 Mobley WC, Server AC, Ishii DN, Riopelle RJ, Shooter EM. Nerve growth factor (third of three parts). The New England Journal of Medicine. 297: 1211-8. PMID 411033 DOI: 10.1056/NEJM197712012972205  1
1977 Mobley WC, Server AC, Ishii DN, Riopelle RJ, Shooter EM. Nerve growth factor (first of three parts). The New England Journal of Medicine. 297: 1096-104. PMID 333290 DOI: 10.1056/NEJM197711172972005  1
1977 Mobley WC, Server AC, Ishii DN, Riopelle RJ, Shooter EM. Nerve growth factor (second of three parts). The New England Journal of Medicine. 297: 1149-58. PMID 72356 DOI: 10.1056/NEJM197711242972105  1
1976 Mobley WC, Schenker A, Shooter EM. Characterization and isolation of proteolytically modified nerve growth factor. Biochemistry. 15: 5543-52. PMID 999827  1
1974 Moore JB, Mobley WC, Shooter EM. Proteolytic modification of the beta nerve growth factor protein. Biochemistry. 13: 833-40. PMID 4811070  1
Show low-probability matches.