| Year |
Citation |
Score |
| 2021 |
Sawa M, Overk C, Becker A, Derse D, Albay R, Weldy K, Salehi A, Beach TG, Doran E, Head E, Yu YE, Mobley WC. Impact of increased APP gene dose in Down syndrome and the Dp16 mouse model. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 34757693 DOI: 10.1002/alz.12463 |
0.587 |
|
| 2020 |
Chen XQ, Salehi A, Pearn ML, Overk C, Nguyen PD, Kleschevnikov AM, Maccecchini M, Mobley WC. Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32975365 DOI: 10.1002/alz.12185 |
0.593 |
|
| 2020 |
Johnstone A, Mobley W. Local TrkB signaling: themes in development and neural plasticity. Cell and Tissue Research. 382: 101-111. PMID 32936344 DOI: 10.1007/S00441-020-03278-7 |
0.364 |
|
| 2020 |
Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD. Author Correction: Reversing a model of Parkinson's disease with in situ converted nigral neurons. Nature. PMID 32724206 DOI: 10.1038/S41586-020-2583-3 |
0.306 |
|
| 2020 |
Stupack J, Xiong XP, Jiang LL, Zhang T, Zhou L, Campos A, Ranscht B, Mobley W, Pasquale EB, Xu H, Huang TY. Soluble SORLA enhances neurite outgrowth and regeneration through activation of the EGF Receptor/ERK signaling axis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 32601248 DOI: 10.1523/Jneurosci.0723-20.2020 |
0.415 |
|
| 2020 |
Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD. Reversing a model of Parkinson's disease with in situ converted nigral neurons. Nature. 582: 550-556. PMID 32581380 DOI: 10.1038/S41586-020-2388-4 |
0.36 |
|
| 2020 |
Snyder HM, Bain LJ, Brickman AM, Carrillo MC, Esbensen AJ, Espinosa JM, Fernandez F, Fortea J, Hartley SL, Head E, Hendrix J, Kishnani PS, Lai F, Lao P, Lemere C, ... Mobley W, et al. Further understanding the connection between Alzheimer's disease and Down syndrome. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32544310 DOI: 10.1002/Alz.12112 |
0.328 |
|
| 2020 |
Kaplan DR, Mobley WC. (H)Elping nerve growth factor: Elp1 inhibits TrkA's phosphatase to maintain retrograde signaling. The Journal of Clinical Investigation. PMID 32281945 DOI: 10.1172/Jci136162 |
0.412 |
|
| 2020 |
Decourt B, Mobley W, Reiman E, Shah RJ, Sabbagh MN. Recent Perspectives on APP, Secretases, Endosomal Pathways and How they Influence Alzheimer's Related Pathological Changes in Down Syndrome. Journal of Alzheimer's Disease & Parkinsonism. 002. PMID 24782952 DOI: 10.4172/2161-0460.S7-002 |
0.343 |
|
| 2019 |
Chen XQ, Mobley WC. Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species. Frontiers in Neuroscience. 13: 659. PMID 31293377 DOI: 10.3389/Fnins.2019.00659 |
0.325 |
|
| 2019 |
Chen XQ, Mobley WC. Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses. Frontiers in Neuroscience. 13: 446. PMID 31133787 DOI: 10.3389/Fnins.2019.00446 |
0.397 |
|
| 2019 |
Escudero CA, Cabeza C, Moya-Alvarado G, Maloney MT, Flores CM, Wu C, Court FA, Mobley WC, Bronfman FC. c-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling. Scientific Reports. 9: 6070. PMID 30988348 DOI: 10.1038/S41598-019-42420-6 |
0.38 |
|
| 2018 |
Chen XQ, Fang F, Florio JB, Rockenstein E, Masliah E, Mobley WC, Rissman RA, Wu C. TRiC enhances retrograde axonal transport by modulating tau phosphorylation. Traffic (Copenhagen, Denmark). PMID 30120810 DOI: 10.1111/Tra.12610 |
0.348 |
|
| 2018 |
Pearn ML, Schilling JM, Jian M, Egawa J, Wu C, Mandyam CD, Fannon-Pavlich MJ, Nguyen U, Bertoglio J, Kodama M, Mahata SK, DerMardirossian C, Lemkuil BP, Han R, Mobley WC, et al. Inhibition of RhoA reduces propofol-mediated growth cone collapse, axonal transport impairment, loss of synaptic connectivity, and behavioural deficits. British Journal of Anaesthesia. 120: 745-760. PMID 29576115 DOI: 10.1016/J.Bja.2017.12.033 |
0.361 |
|
| 2018 |
Sung K, Ferrari LF, Yang W, Chung C, Zhao X, Gu Y, Lin S, Zhang K, Cui B, Pearn ML, Maloney MT, Mobley WC, Levine JD, Wu C. Swedish Nerve Growth Factor Mutation (NGF) Defines a Role for TrkA and p75in Nociception. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29483280 DOI: 10.1523/Jneurosci.1686-17.2018 |
0.411 |
|
| 2017 |
Chen XQ, Sawa M, Mobley WC. Dysregulation of Neurotrophin Signaling in the Pathogenesis of Alzheimer Disease and of Alzheimer Disease in Down Syndrome. Free Radical Biology & Medicine. PMID 29031834 DOI: 10.1016/J.Freeradbiomed.2017.10.341 |
0.398 |
|
| 2017 |
Rafii MS, Lukic AS, Andrews RD, Brewer J, Rissman RA, Strother SC, Wernick MN, Pennington C, Mobley WC, Ness S, Matthews DC. PET Imaging of Tau Pathology and Relationship to Amyloid, Longitudinal MRI, and Cognitive Change in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI). Journal of Alzheimer's Disease : Jad. 60: 439-450. PMID 28946567 DOI: 10.3233/Jad-170390 |
0.322 |
|
| 2017 |
Bradshaw RA, Mobley W, Rush RA. Nerve Growth Factor and Related Substances: A Brief History and an Introduction to the International NGF Meeting Series. International Journal of Molecular Sciences. 18. PMID 28587118 DOI: 10.3390/Ijms18061143 |
0.374 |
|
| 2017 |
Wagner SL, Rynearson KD, Duddy SK, Zhang C, Nguyen PD, Becker A, Vo U, Masliah D, Monte L, Klee JB, Echmalian CM, Xia W, Quinti L, Johnson G, Lin JH, ... ... Mobley WC, et al. Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606. The Journal of Pharmacology and Experimental Therapeutics. PMID 28416568 DOI: 10.1124/Jpet.117.240861 |
0.3 |
|
| 2017 |
Kleschevnikov AM, Yu J, Kim J, Lysenko LV, Zhen Z, Eugene Yu Y, Mobley WC. Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome. Neurobiology of Disease. PMID 28342823 DOI: 10.1016/J.Nbd.2017.03.009 |
0.331 |
|
| 2016 |
Matthews DC, Lukic AS, Andrews RD, Marendic B, Brewer J, Rissman RA, Mosconi L, Strother SC, Wernick MN, Mobley WC, Ness S, Schmidt ME, Rafii MS. Dissociation of Down syndrome and Alzheimer's disease effects with imaging. Alzheimer's & Dementia (New York, N. Y.). 2: 69-81. PMID 28642933 DOI: 10.1016/J.Trci.2016.02.004 |
0.322 |
|
| 2016 |
Mojabi FS, Fahimi A, Moghadam S, Moghadam S, McNerneny MW, Ponnusamy R, Kleschevnikov A, Mobley WC, Salehi A. GABAergic Hyperinnervation of Dentate Granule Cells in the Ts65Dn Mouse Model of Down Syndrome Exploring the Role of App. Hippocampus. PMID 27701794 DOI: 10.1002/Hipo.22664 |
0.78 |
|
| 2016 |
Zhao X, Chen XQ, Han E, Hu Y, Paik P, Ding Z, Overman J, Lau AL, Shahmoradian SH, Chiu W, Thompson LM, Wu C, Mobley WC. TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 27601642 DOI: 10.1073/Pnas.1603020113 |
0.389 |
|
| 2016 |
Ballard C, Mobley W, Hardy J, Williams G, Corbett A. Dementia in Down's syndrome. The Lancet. Neurology. 15: 622-36. PMID 27302127 DOI: 10.1016/S1474-4422(16)00063-6 |
0.309 |
|
| 2016 |
Xu W, Weissmiller AM, White JA, Fang F, Wang X, Wu Y, Pearn ML, Zhao X, Sawa M, Chen S, Gunawardena S, Ding J, Mobley WC, Wu C. Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration. The Journal of Clinical Investigation. PMID 27064279 DOI: 10.1172/Jci82409 |
0.752 |
|
| 2016 |
Belichenko PV, Madani R, Rey-Bellet L, Pihlgren M, Becker A, Plassard A, Vuillermot S, Giriens V, Nosheny RL, Kleschevnikov AM, Valletta JS, Bengtsson SK, Linke GR, Maloney MT, Hickman DT, ... ... Mobley WC, et al. An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome. Plos One. 11: e0152471. PMID 27023444 DOI: 10.1371/Journal.Pone.0152471 |
0.334 |
|
| 2015 |
Rafii MS, Wishnek H, Brewer JB, Donohue MC, Ness S, Mobley WC, Aisen PS, Rissman RA. The down syndrome biomarker initiative (DSBI) pilot: proof of concept for deep phenotyping of Alzheimer's disease biomarkers in down syndrome. Frontiers in Behavioral Neuroscience. 9: 239. PMID 26441570 DOI: 10.3389/Fnbeh.2015.00239 |
0.302 |
|
| 2015 |
Jiang X, Liu C, Yu T, Zhang L, Meng K, Xing Z, Belichenko PV, Pao A, Peresie J, Wie S, Mobley WC, Yu YE. Genetic Dissection of the Down Syndrome Critical Region. Human Molecular Genetics. PMID 26374847 DOI: 10.1093/Hmg/Ddv364 |
0.313 |
|
| 2015 |
Zhao Y, Tseng IC, Heyser CJ, Rockenstein E, Mante M, Adame A, Zheng Q, Huang T, Wang X, Arslan PE, Chakrabarty P, Wu C, Bu G, Mobley WC, Zhang YW, et al. Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Neuron. 87: 963-75. PMID 26335643 DOI: 10.1016/J.Neuron.2015.08.020 |
0.303 |
|
| 2015 |
Belichenko PV, Kleschevnikov AM, Becker A, Wagner GE, Lysenko LV, Yu YE, Mobley WC. Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues. Plos One. 10: e0134861. PMID 26230397 DOI: 10.1371/Journal.Pone.0134861 |
0.321 |
|
| 2015 |
Selfridge A, Hyun N, Chiang CC, Reyna SM, Weissmiller AM, Shi LZ, Preece D, Mobley WC, Berns MW. Rat embryonic hippocampus and induced pluripotent stem cell derived cultured neurons recover from laser-induced subaxotomy. Neurophotonics. 2: 015006. PMID 26157985 DOI: 10.1117/1.Nph.2.1.015006 |
0.716 |
|
| 2015 |
Nosheny RL, Belichenko PV, Busse BL, Weissmiller AM, Dang V, Das D, Fahimi A, Salehi A, Smith SJ, Mobley WC. Increased cortical synaptic activation of TrkB and downstream signaling markers in a mouse model of Down Syndrome. Neurobiology of Disease. 77: 173-90. PMID 25753471 DOI: 10.1016/J.Nbd.2015.02.022 |
0.772 |
|
| 2015 |
Weissmiller AM, Natera-Naranjo O, Reyna SM, Pearn ML, Zhao X, Nguyen P, Cheng S, Goldstein LS, Tanzi RE, Wagner SL, Mobley WC, Wu C. A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. Plos One. 10: e0118379. PMID 25710492 DOI: 10.1371/Journal.Pone.0118379 |
0.752 |
|
| 2015 |
Hartley D, Blumenthal T, Carrillo M, DiPaolo G, Esralew L, Gardiner K, Granholm AC, Iqbal K, Krams M, Lemere C, Lott I, Mobley W, Ness S, Nixon R, Potter H, et al. Down syndrome and Alzheimer's disease: Common pathways, common goals. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 700-9. PMID 25510383 DOI: 10.1016/J.Jalz.2014.10.007 |
0.341 |
|
| 2014 |
Fargo KN, Aisen P, Albert M, Au R, Corrada MM, DeKosky S, Drachman D, Fillit H, Gitlin L, Haas M, Herrup K, Kawas C, Khachaturian AS, Khachaturian ZS, ... ... Mobley W, et al. 2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: S430-52. PMID 25341459 DOI: 10.1016/J.Jalz.2014.08.103 |
0.515 |
|
| 2014 |
Zhao X, Zhou Y, Weissmiller AM, Pearn ML, Mobley WC, Wu C. Real-time imaging of axonal transport of quantum dot-labeled BDNF in primary neurons. Journal of Visualized Experiments : Jove. 51899. PMID 25286194 DOI: 10.3791/51899 |
0.724 |
|
| 2014 |
Shahmoradian SH, Galiano MR, Wu C, Chen S, Rasband MN, Mobley WC, Chiu W. Preparation of primary neurons for visualizing neurites in a frozen-hydrated state using cryo-electron tomography. Journal of Visualized Experiments : Jove. e50783. PMID 24561719 DOI: 10.3791/50783 |
0.345 |
|
| 2014 |
Zhang L, Meng K, Jiang X, Liu C, Pao A, Belichenko PV, Kleschevnikov AM, Josselyn S, Liang P, Ye P, Mobley WC, Yu YE. Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits. Human Molecular Genetics. 23: 578-89. PMID 24041763 DOI: 10.1093/Hmg/Ddt446 |
0.322 |
|
| 2013 |
Zhang H, Petit GH, Gaughwin PM, Hansen C, Ranganathan S, Zuo X, Smith R, Roybon L, Brundin P, Mobley WC, Li JY. NGF rescues hippocampal cholinergic neuronal markers, restores neurogenesis, and improves the spatial working memory in a mouse model of Huntington's Disease. Journal of Huntington's Disease. 2: 69-82. PMID 25063430 DOI: 10.3233/Jhd-120026 |
0.419 |
|
| 2013 |
Ruparelia A, Pearn ML, Mobley WC. Aging and intellectual disability: insights from mouse models of Down syndrome. Developmental Disabilities Research Reviews. 18: 43-50. PMID 23949828 DOI: 10.1002/Ddrr.1127 |
0.335 |
|
| 2013 |
Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, et al. Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nature Medicine. 19: 473-80. PMID 23524343 DOI: 10.1038/Nm.3117 |
0.376 |
|
| 2013 |
Wang X, Zhao Y, Zhang X, Zhou Y, Ranscht B, Gage FH, Mobley WC, Zhang Y, Lipton SA, Hong W, Xu H. A novel mechanism underlying pathogenesis of Down syndrome Molecular Neurodegeneration. 8: O23. DOI: 10.1186/1750-1326-8-S1-O23 |
0.329 |
|
| 2012 |
Kleschevnikov AM, Belichenko PV, Faizi M, Jacobs LF, Htun K, Shamloo M, Mobley WC. Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 9217-27. PMID 22764230 DOI: 10.1523/Jneurosci.1673-12.2012 |
0.323 |
|
| 2012 |
Ruparelia A, Pearn ML, Mobley WC. Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome. Current Opinion in Neurobiology. 22: 880-6. PMID 22658745 DOI: 10.1016/J.Conb.2012.05.002 |
0.322 |
|
| 2012 |
Zhang L, Fu D, Belichenko PV, Liu C, Kleschevnikov AM, Pao A, Liang P, Clapcote SJ, Mobley WC, Yu YE. Genetic analysis of Down syndrome facilitated by mouse chromosome engineering. Bioengineered Bugs. 3: 8-12. PMID 22126738 DOI: 10.4161/Bbug.3.1.17696 |
0.317 |
|
| 2012 |
Kleschevnikov AM, Belichenko PV, Gall J, George L, Nosheny R, Maloney MT, Salehi A, Mobley WC. Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome. Neurobiology of Disease. 45: 683-91. PMID 22062771 DOI: 10.1016/J.Nbd.2011.10.009 |
0.63 |
|
| 2011 |
Liu C, Belichenko PV, Zhang L, Fu D, Kleschevnikov AM, Baldini A, Antonarakis SE, Mobley WC, Yu YE. Mouse models for Down syndrome-associated developmental cognitive disabilities. Developmental Neuroscience. 33: 404-13. PMID 21865664 DOI: 10.1159/000329422 |
0.321 |
|
| 2011 |
Faizi M, Bader PL, Tun C, Encarnacion A, Kleschevnikov A, Belichenko P, Saw N, Priestley M, Tsien RW, Mobley WC, Shamloo M. Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer. Neurobiology of Disease. 43: 397-413. PMID 21527343 DOI: 10.1016/J.Nbd.2011.04.011 |
0.33 |
|
| 2011 |
Rissman RA, Mobley WC. Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease. Journal of Neurochemistry. 117: 613-22. PMID 21388375 DOI: 10.1111/J.1471-4159.2011.07237.X |
0.328 |
|
| 2010 |
Yu T, Liu C, Belichenko P, Clapcote SJ, Li S, Pao A, Kleschevnikov A, Bechard AR, Asrar S, Chen R, Fan N, Zhou Z, Jia Z, Chen C, Roder JC, ... ... Mobley WC, et al. Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice. Brain Research. 1366: 162-71. PMID 20932954 DOI: 10.1016/J.Brainres.2010.09.107 |
0.302 |
|
| 2010 |
Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, ... ... Mobley WC, et al. Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron. 67: 769-80. PMID 20826309 DOI: 10.1016/J.Neuron.2010.08.018 |
0.3 |
|
| 2010 |
Yu T, Clapcote SJ, Li Z, Liu C, Pao A, Bechard AR, Carattini-Rivera S, Matsui S, Roder JC, Baldini A, Mobley WC, Bradley A, Yu YE. Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 21: 258-67. PMID 20512340 DOI: 10.1007/S00335-010-9262-X |
0.309 |
|
| 2009 |
Salehi A, Faizi M, Colas D, Valletta J, Laguna J, Takimoto-Kimura R, Kleschevnikov A, Wagner SL, Aisen P, Shamloo M, Mobley WC. Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome. Science Translational Medicine. 1: 7ra17. PMID 20368182 DOI: 10.1126/Scitranslmed.3000258 |
0.641 |
|
| 2009 |
Tamaki SJ, Jacobs Y, Dohse M, Capela A, Cooper JD, Reitsma M, He D, Tushinski R, Belichenko PV, Salehi A, Mobley W, Gage FH, Huhn S, Tsukamoto AS, Weissman IL, et al. Neuroprotection of host cells by human central nervous system stem cells in a mouse model of infantile neuronal ceroid lipofuscinosis. Cell Stem Cell. 5: 310-9. PMID 19733542 DOI: 10.1016/J.Stem.2009.05.022 |
0.641 |
|
| 2009 |
Belichenko NP, Belichenko PV, Kleschevnikov AM, Salehi A, Reeves RH, Mobley WC. The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 5938-48. PMID 19420260 DOI: 10.1523/Jneurosci.1547-09.2009 |
0.641 |
|
| 2009 |
Belichenko PV, Wright EE, Belichenko NP, Masliah E, Li HH, Mobley WC, Francke U. Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: evidence for disruption of neuronal networks. The Journal of Comparative Neurology. 514: 240-58. PMID 19296534 DOI: 10.1002/Cne.22009 |
0.352 |
|
| 2009 |
Belichenko NP, Belichenko PV, Mobley WC. Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation. Neurobiology of Disease. 34: 71-7. PMID 19167498 DOI: 10.1016/J.Nbd.2008.12.016 |
0.348 |
|
| 2009 |
Belichenko PV, Kleschevnikov AM, Masliah E, Wu C, Takimoto-Kimura R, Salehi A, Mobley WC. Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome. The Journal of Comparative Neurology. 512: 453-66. PMID 19034952 DOI: 10.1002/Cne.21895 |
0.629 |
|
| 2009 |
Wu C, Cui B, He L, Chen L, Mobley WC. The coming of age of axonal neurotrophin signaling endosomes. Journal of Proteomics. 72: 46-55. PMID 19028611 DOI: 10.1016/J.Jprot.2008.10.007 |
0.38 |
|
| 2008 |
Wan J, Cheung AY, Fu WY, Wu C, Zhang M, Mobley WC, Cheung ZH, Ip NY. Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 9002-12. PMID 18768694 DOI: 10.1523/Jneurosci.0767-08.2008 |
0.389 |
|
| 2008 |
Belichenko NP, Belichenko PV, Li HH, Mobley WC, Francke U. Comparative study of brain morphology in Mecp2 mutant mouse models of Rett syndrome. The Journal of Comparative Neurology. 508: 184-95. PMID 18306326 DOI: 10.1002/Cne.21673 |
0.319 |
|
| 2008 |
Kleschevnikov AM, Belichenko PV, Mobley W. P1-036: Suppression of GABAB receptors increases LTP without inducing pro-epileptic activity in the dentate gyrus of Ts65Dn mice, a genetic model for Down syndrome Alzheimer's & Dementia. 4: T216-T216. DOI: 10.1016/J.Jalz.2008.05.621 |
0.323 |
|
| 2008 |
Salehi A, Faizi M, Takimoto R, Valletta J, Danks A, Mobley WC. P2-308: Examining the effects of (+)-phenserine in Ts65Dn mouse model of down syndrome Alzheimer's & Dementia. 4: T462-T463. DOI: 10.1016/J.Jalz.2008.05.1385 |
0.604 |
|
| 2007 |
Salehi A, Faizi M, Belichenko PV, Mobley WC. Using mouse models to explore genotype-phenotype relationship in Down syndrome. Mental Retardation and Developmental Disabilities Research Reviews. 13: 207-14. PMID 17910089 DOI: 10.1002/Mrdd.20164 |
0.653 |
|
| 2007 |
Wu C, Ramirez A, Cui B, Ding J, Delcroix JD, Valletta JS, Liu JJ, Yang Y, Chu S, Mobley WC. A functional dynein-microtubule network is required for NGF signaling through the Rap1/MAPK pathway. Traffic (Copenhagen, Denmark). 8: 1503-20. PMID 17822405 DOI: 10.1111/J.1600-0854.2007.00636.X |
0.397 |
|
| 2007 |
Cui B, Wu C, Chen L, Ramirez A, Bearer EL, Li WP, Mobley WC, Chu S. One at a time, live tracking of NGF axonal transport using quantum dots. Proceedings of the National Academy of Sciences of the United States of America. 104: 13666-71. PMID 17698956 DOI: 10.1073/Pnas.0706192104 |
0.394 |
|
| 2007 |
Belichenko PV, Kleschevnikov AM, Salehi A, Epstein CJ, Mobley WC. Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships. The Journal of Comparative Neurology. 504: 329-45. PMID 17663443 DOI: 10.1002/Cne.21433 |
0.634 |
|
| 2007 |
Liu JJ, Ding J, Wu C, Bhagavatula P, Cui B, Chu S, Mobley WC, Yang Y. Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport. Proceedings of the National Academy of Sciences of the United States of America. 104: 2223-8. PMID 17287360 DOI: 10.1073/Pnas.0602222104 |
0.316 |
|
| 2007 |
Salehi A, Kleshevnikov A, Mobley WC. Cholinergic neurodegeneration in Alzheimer's disease: Basis for nerve growth factor therapy Pharmacological Mechanisms in Alzheimer's Therapeutics. 64-104. DOI: 10.1007/978-0-387-71522-3_5 |
0.597 |
|
| 2006 |
Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, ... ... Mobley WC, et al. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 51: 29-42. PMID 16815330 DOI: 10.1016/J.Neuron.2006.05.022 |
0.69 |
|
| 2006 |
Miyamoto Y, Yamauchi J, Tanoue A, Wu C, Mobley WC. TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology. Proceedings of the National Academy of Sciences of the United States of America. 103: 10444-9. PMID 16801538 DOI: 10.1073/Pnas.0603914103 |
0.375 |
|
| 2006 |
Ding J, Allen E, Wang W, Valle A, Wu C, Nardine T, Cui B, Yi J, Taylor A, Jeon NL, Chu S, So Y, Vogel H, Tolwani R, Mobley W, et al. Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport. Human Molecular Genetics. 15: 1451-63. PMID 16565160 DOI: 10.1093/Hmg/Ddl069 |
0.359 |
|
| 2006 |
Watson G, Bastacky J, Belichenko P, Buddhikot M, Jungles S, Vellard M, Mobley WC, Kakkis E. Intrathecal administration of AAV vectors for the treatment of lysosomal storage in the brains of MPS I mice. Gene Therapy. 13: 917-25. PMID 16482204 DOI: 10.1038/Sj.Gt.3302735 |
0.306 |
|
| 2005 |
Villar AJ, Belichenko PV, Gillespie AM, Kozy HM, Mobley WC, Epstein CJ. Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 16: 79-90. PMID 15859352 DOI: 10.1007/S00335-004-2428-7 |
0.319 |
|
| 2005 |
Howe CL, Mobley WC. Long-distance retrograde neurotrophic signaling. Current Opinion in Neurobiology. 15: 40-8. PMID 15721743 DOI: 10.1016/J.Conb.2005.01.010 |
0.621 |
|
| 2004 |
Belichenko PV, Masliah E, Kleschevnikov AM, Villar AJ, Epstein CJ, Salehi A, Mobley WC. Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome. The Journal of Comparative Neurology. 480: 281-98. PMID 15515178 DOI: 10.1002/Cne.20337 |
0.638 |
|
| 2004 |
Pontikis CC, Cella CV, Parihar N, Lim MJ, Chakrabarti S, Mitchison HM, Mobley WC, Rezaie P, Pearce DA, Cooper JD. Late onset neurodegeneration in the Cln3-/- mouse model of juvenile neuronal ceroid lipofuscinosis is preceded by low level glial activation. Brain Research. 1023: 231-42. PMID 15374749 DOI: 10.1016/J.Brainres.2004.07.030 |
0.374 |
|
| 2004 |
Kleschevnikov AM, Belichenko PV, Villar AJ, Epstein CJ, Malenka RC, Mobley WC. Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 8153-60. PMID 15371516 DOI: 10.1523/Jneurosci.1766-04.2004 |
0.34 |
|
| 2004 |
Reichardt LF, Mobley WC. Going the distance, or not, with neurotrophin signals. Cell. 118: 141-3. PMID 15260984 DOI: 10.1016/J.Cell.2004.07.008 |
0.423 |
|
| 2004 |
Howe CL, Mobley WC. Signaling endosome hypothesis: A cellular mechanism for long distance communication. Journal of Neurobiology. 58: 207-16. PMID 14704953 DOI: 10.1002/Neu.10323 |
0.576 |
|
| 2004 |
Delcroix JD, Valletta J, Wu C, Howe CL, Lai CF, Cooper JD, Belichenko PV, Salehi A, Mobley WC. Trafficking the NGF signal: implications for normal and degenerating neurons. Progress in Brain Research. 146: 3-23. PMID 14699953 DOI: 10.1016/S0079-6123(03)46001-9 |
0.75 |
|
| 2004 |
Kleschevnikov AM, Belichenko PV, Epstein CJ, Villar AJ, Malenka R, Mobley WC. P2-101 Reduced LTP and enhanced inhibition in dentate gyrus of TS65DN mice, a model for down's syndrome Neurobiology of Aging. 25: S252. DOI: 10.1016/S0197-4580(04)80848-0 |
0.316 |
|
| 2004 |
Salehi A, Delcroix J, Xia W, Sambamurti K, Mobley WC. P1-254 APP and β-amyloid levels in segmental trisomy mouse model of down syndrome Neurobiology of Aging. 25: S168. DOI: 10.1016/S0197-4580(04)80567-0 |
0.602 |
|
| 2004 |
Delcroix J, Salehi A, Mobley W. S4-01-03 Trafficking the target-derived signals of neurotrophic factors: implications for normal and degenerating neurons Neurobiology of Aging. 25: S67. DOI: 10.1016/S0197-4580(04)80227-6 |
0.648 |
|
| 2003 |
Liu JJ, Ding J, Kowal AS, Nardine T, Allen E, Delcroix JD, Wu C, Mobley W, Fuchs E, Yang Y. BPAG1n4 is essential for retrograde axonal transport in sensory neurons. The Journal of Cell Biology. 163: 223-9. PMID 14581450 DOI: 10.1083/Jcb.200306075 |
0.355 |
|
| 2003 |
Delcroix JD, Valletta JS, Wu C, Hunt SJ, Kowal AS, Mobley WC. NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals. Neuron. 39: 69-84. PMID 12848933 DOI: 10.1016/S0896-6273(03)00397-0 |
0.411 |
|
| 2003 |
Salehi A, Delcroix JD, Mobley WC. Traffic at the intersection of neurotrophic factor signaling and neurodegeneration. Trends in Neurosciences. 26: 73-80. PMID 12536130 DOI: 10.1016/S0166-2236(02)00038-3 |
0.677 |
|
| 2001 |
Howe CL, Valletta JS, Rusnak AS, Mobley WC. NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway. Neuron. 32: 801-14. PMID 11738027 DOI: 10.1016/S0896-6273(01)00526-8 |
0.632 |
|
| 2001 |
Sofroniew MV, Howe CL, Mobley WC. Nerve growth factor signaling, neuroprotection, and neural repair. Annual Review of Neuroscience. 24: 1217-81. PMID 11520933 DOI: 10.1146/Annurev.Neuro.24.1.1217 |
0.647 |
|
| 2001 |
Cooper JD, Salehi A, Delcroix JD, Howe CL, Belichenko PV, Chua-Couzens J, Kilbridge JF, Carlson EJ, Epstein CJ, Mobley WC. Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion. Proceedings of the National Academy of Sciences of the United States of America. 98: 10439-44. PMID 11504920 DOI: 10.1073/Pnas.181219298 |
0.763 |
|
| 2001 |
Wu C, Lai CF, Mobley WC. Nerve growth factor activates persistent Rap1 signaling in endosomes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 5406-16. PMID 11466412 DOI: 10.1523/Jneurosci.21-15-05406.2001 |
0.344 |
|
| 2001 |
Cooper JD, Mobley WC. Neurotrophic factors as potential therapeutic agents in neuronal ceroid lipofuscinosis. Advances in Genetics. 45: 169-82. PMID 11332772 DOI: 10.1016/S0065-2660(01)45010-3 |
0.452 |
|
| 2001 |
Mischel PS, Smith SG, Vining ER, Valletta JS, Mobley WC, Reichardt LF. The extracellular domain of p75NTR is necessary to inhibit neurotrophin-3 signaling through TrkA. The Journal of Biological Chemistry. 276: 11294-301. PMID 11150291 DOI: 10.1074/Jbc.M005132200 |
0.329 |
|
| 2000 |
Lynch C, Mobley W. Comprehensive theory of Alzheimer's disease. The effects of cholesterol on membrane receptor trafficking Annals of the New York Academy of Sciences. 924: 104-111. PMID 11193786 DOI: 10.1111/J.1749-6632.2000.Tb05568.X |
0.379 |
|
| 2000 |
Beattie EC, Howe CL, Wilde A, Brodsky FM, Mobley WC. NGF signals through TrkA to increase clathrin at the plasma membrane and enhance clathrin-mediated membrane trafficking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 7325-33. PMID 11007890 DOI: 10.1523/Jneurosci.20-19-07325.2000 |
0.611 |
|
| 2000 |
Villoslada P, Hauser SL, Bartke I, Unger J, Heald N, Rosenberg D, Cheung SW, Mobley WC, Fisher S, Genain CP. Human nerve growth factor protects common marmosets against autoimmune encephalomyelitis by switching the balance of T helper cell type 1 and 2 cytokines within the central nervous system. The Journal of Experimental Medicine. 191: 1799-806. PMID 10811872 DOI: 10.1084/Jem.191.10.1799 |
0.356 |
|
| 2000 |
Salehi A, Cooper JD, Alonso MA, Swaab DF, Mobley WC. Neurotrophin receptors in Alzheimer brain and A mouse model of down syndrome Neurobiology of Aging. 21: 114. DOI: 10.1016/S0197-4580(00)82310-6 |
0.678 |
|
| 1999 |
Huang CS, Zhou J, Feng AK, Lynch CC, Klumperman J, DeArmond SJ, Mobley WC. Nerve growth factor signaling in caveolae-like domains at the plasma membrane. The Journal of Biological Chemistry. 274: 36707-14. PMID 10593976 DOI: 10.1074/Jbc.274.51.36707 |
0.37 |
|
| 1999 |
Mitchison HM, Bernard DJ, Greene ND, Cooper JD, Junaid MA, Pullarkat RK, de Vos N, Breuning MH, Owens JW, Mobley WC, Gardiner RM, Lake BD, Taschner PE, Nussbaum RL. Targeted disruption of the Cln3 gene provides a mouse model for Batten disease. The Batten Mouse Model Consortium [corrected]. Neurobiology of Disease. 6: 321-34. PMID 10527801 DOI: 10.1006/Nbdi.1999.0267 |
0.348 |
|
| 1999 |
Yuen EC, Mobley WC. Early BDNF, NT-3, and NT-4 signaling events. Experimental Neurology. 159: 297-308. PMID 10486198 DOI: 10.1006/Exnr.1999.7148 |
0.352 |
|
| 1999 |
Cooper JD, Messer A, Feng AK, Chua-Couzens J, Mobley WC. Apparent loss and hypertrophy of interneurons in a mouse model of neuronal ceroid lipofuscinosis: evidence for partial response to insulin-like growth factor-1 treatment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 2556-67. PMID 10087069 DOI: 10.1523/Jneurosci.19-07-02556.1999 |
0.4 |
|
| 1999 |
Cooper JD, Mobley WC. Pathologic Involvement of Interneurons in Mouse Models of Neuronal Ceroid Lipofuscinosis Pediatric Research. 45: 340A-340A. DOI: 10.1203/00006450-199904020-02021 |
0.358 |
|
| 1998 |
Butte MJ, Hwang PK, Mobley WC, Fletterick RJ. Crystal structure of neurotrophin-3 homodimer shows distinct regions are used to bind its receptors. Biochemistry. 37: 16846-52. PMID 9836577 DOI: 10.1021/Bi981254O |
0.313 |
|
| 1998 |
Fagan AM, Murphy BA, Patel SN, Kilbridge JF, Mobley WC, Bu G, Holtzman DM. Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury. Experimental Neurology. 151: 314-25. PMID 9628766 DOI: 10.1006/Exnr.1998.6818 |
0.517 |
|
| 1998 |
Sago H, Carlson EJ, Smith DJ, Kilbridge J, Rubin EM, Mobley WC, Epstein CJ, Huang TT. Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities. Proceedings of the National Academy of Sciences of the United States of America. 95: 6256-61. PMID 9600952 DOI: 10.1073/Pnas.95.11.6256 |
0.311 |
|
| 1997 |
Schätzl HM, Laszlo L, Holtzman DM, Tatzelt J, DeArmond SJ, Weiner RI, Mobley WC, Prusiner SB. A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis. Journal of Virology. 71: 8821-31. PMID 9343242 DOI: 10.1128/Jvi.71.11.8821-8831.1997 |
0.483 |
|
| 1997 |
Yeo TT, Chua-Couzens J, Butcher LL, Bredesen DE, Cooper JD, Valletta JS, Mobley WC, Longo FM. Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 7594-605. PMID 9315882 DOI: 10.1523/Jneurosci.17-20-07594.1997 |
0.4 |
|
| 1997 |
Grimes ML, Beattie E, Mobley WC. A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA. Proceedings of the National Academy of Sciences of the United States of America. 94: 9909-14. PMID 9275225 DOI: 10.1073/Pnas.94.18.9909 |
0.418 |
|
| 1996 |
Beattie EC, Zhou J, Grimes ML, Bunnett NW, Howe CL, Mobley WC. A signaling endosome hypothesis to explain NGF actions: potential implications for neurodegeneration. Cold Spring Harbor Symposia On Quantitative Biology. 61: 389-406. PMID 9246468 DOI: 10.1101/Sqb.1996.061.01.042 |
0.609 |
|
| 1996 |
Grimes ML, Zhou J, Beattie EC, Yuen EC, Hall DE, Valletta JS, Topp KS, LaVail JH, Bunnett NW, Mobley WC. Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 7950-64. PMID 8987823 DOI: 10.1523/Jneurosci.16-24-07950.1996 |
0.412 |
|
| 1996 |
Holtzman DM, Santucci D, Kilbridge J, Chua-Couzens J, Fontana DJ, Daniels SE, Johnson RM, Chen K, Sun Y, Carlson E, Alleva E, Epstein CJ, Mobley WC. Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome. Proceedings of the National Academy of Sciences of the United States of America. 93: 13333-8. PMID 8917591 DOI: 10.1073/Pnas.93.23.13333 |
0.513 |
|
| 1996 |
Yuen EC, Howe CL, Li Y, Holtzman DM, Mobley WC. Nerve growth factor and the neurotrophic factor hypothesis. Brain & Development. 18: 362-8. PMID 8891230 DOI: 10.1016/0387-7604(96)00051-4 |
0.691 |
|
| 1996 |
Holtzman DM, Lee S, Li Y, Chua-Couzens J, Xia H, Bredt DS, Mobley WC. Expression of neuronal-NOS in developing basal forebrain cholinergic neurons: regulation by NGF. Neurochemical Research. 21: 861-8. PMID 8873091 DOI: 10.1007/Bf02532310 |
0.515 |
|
| 1996 |
Neve RL, Valletta JS, Li Y, Ventosa-Michelman M, Holtzman DM, Mobley WC. A comprehensive study of the spatiotemporal pattern of beta-amyloid precursor protein mRNA and protein in the rat brain: lack of modulation by exogenously applied nerve growth factor. Brain Research. Molecular Brain Research. 39: 185-97. PMID 8804727 DOI: 10.1016/0169-328X(96)00007-1 |
0.466 |
|
| 1996 |
Mobley WC. 340 Neurotrophin signalling: Implications for neurodegeneration Neurobiology of Aging. 17: S85. DOI: 10.1016/S0197-4580(96)80342-3 |
0.313 |
|
| 1996 |
Holtzman DM, Epstein CJ, Mobley WC. The human trisomy 21 brain: Insights from mouse models of Down syndrome Mental Retardation and Developmental Disabilities Research Reviews. 2: 66-72. DOI: 10.1002/(Sici)1098-2779(1996)2:2<66::Aid-Mrdd2>3.0.Co;2-V |
0.491 |
|
| 1995 |
Yuen EC, Mobley WC. Therapeutic applications of neurotrophic factors in disorders of motor neurons and peripheral nerves. Molecular Medicine Today. 1: 278-86. PMID 9415162 DOI: 10.1016/S1357-4310(95)91189-8 |
0.355 |
|
| 1995 |
Holtzman DM, Kilbridge J, Chen KS, Rabin J, Luche R, Carlson E, Epstein CJ, Mobley WC. Preliminary characterization of the central nervous system in partial trisomy 16 mice. Progress in Clinical and Biological Research. 393: 227-40. PMID 8545453 |
0.366 |
|
| 1995 |
Holtzman DM, Kilbridge J, Li Y, Cunningham ET, Lenn NJ, Clary DO, Reichardt LF, Mobley WC. TrkA expression in the CNS: evidence for the existence of several novel NGF-responsive CNS neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 1567-76. PMID 7869118 DOI: 10.1523/Jneurosci.15-02-01567.1995 |
0.533 |
|
| 1995 |
Zhou J, Valletta JS, Grimes ML, Mobley WC. Multiple levels for regulation of TrkA in PC12 cells by nerve growth factor. Journal of Neurochemistry. 65: 1146-56. PMID 7543930 DOI: 10.1046/J.1471-4159.1995.65031146.X |
0.398 |
|
| 1995 |
Li Y, Holtzman DM, Kromer LF, Kaplan DR, Chua-Couzens J, Clary DO, Knüsel B, Mobley WC. Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 2888-905. PMID 7536822 DOI: 10.1523/Jneurosci.15-04-02888.1995 |
0.531 |
|
| 1994 |
Holtzman DM, Kilbridge J, Bredt DS, Black SM, Li Y, Clary DO, Reichardt LF, Mobley WC. NOS induction by NGF in basal forebrain cholinergic neurones: evidence for regulation of brain NOS by a neurotrophin. Neurobiology of Disease. 1: 51-60. PMID 9216986 DOI: 10.1006/Nbdi.1994.0007 |
0.527 |
|
| 1994 |
Zhou J, Holtzman DM, Weiner RI, Mobley WC. Expression of TrkA confers neuron-like responsiveness to nerve growth factor on an immortalized hypothalamic cell line. Proceedings of the National Academy of Sciences of the United States of America. 91: 3824-8. PMID 8170995 DOI: 10.1073/Pnas.91.9.3824 |
0.546 |
|
| 1994 |
Chen CK, Kinsman SL, Holtzman DM, Mobley WC, Johnston MV. A reverse transcription-polymerase chain reaction study of p75 nerve growth factor receptor gene expression in developing rat cerebellum. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 12: 255-62. PMID 7976482 DOI: 10.1016/0736-5748(94)90072-8 |
0.456 |
|
| 1994 |
Holtzman DM, Mobley WC. Neurotrophic factors and neurologic disease. The Western Journal of Medicine. 161: 246-54. PMID 7975562 |
0.444 |
|
| 1994 |
Burke MA, Mobley WC, Cho J, Wiegand SJ, Lindsay RM, Mufson EJ, Kordower JH. Loss of developing cholinergic basal forebrain neurons following excitotoxic lesions of the hippocampus: rescue by neurotrophins. Experimental Neurology. 130: 178-95. PMID 7867749 DOI: 10.1006/Exnr.1994.1197 |
0.412 |
|
| 1994 |
Higgins LS, Holtzman DM, Rabin J, Mobley WC, Cordell B. Transgenic mouse brain histopathology resembles early Alzheimer's disease. Annals of Neurology. 35: 598-607. PMID 7513982 DOI: 10.1002/Ana.410350514 |
0.46 |
|
| 1993 |
Holtzman DM, Li Y, Chen K, Gage FH, Epstein CJ, Mobley WC. Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration. Neurology. 43: 2668-73. PMID 8255474 DOI: 10.1212/Wnl.43.12.2668 |
0.58 |
|
| 1993 |
Sofroniew MV, Mobley WC. On the possibility of positive-feedback in trophic interactions between afferent and target neurons Seminars in Neuroscience. 5: 309-312. DOI: 10.1016/S1044-5765(05)80036-3 |
0.378 |
|
| 1993 |
Grimes M, Zhou J, Li Y, Holtzman D, Mobley WC. Neurotrophin signalling in the nervous system Seminars in Neuroscience. 5: 239-247. DOI: 10.1016/S1044-5765(05)80029-6 |
0.543 |
|
| 1992 |
Holtzman DM, Li YW, DeArmond SJ, McKinley MP, Gage FH, Epstein CJ, Mobley WC. Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants. Proceedings of the National Academy of Sciences of the United States of America. 89: 1383-7. PMID 1741393 DOI: 10.1073/Pnas.89.4.1383 |
0.541 |
|
| 1992 |
Holtzman DM, Li Y, Parada LF, Kinsman S, Chen CK, Valletta JS, Zhou J, Long JB, Mobley WC. p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF. Neuron. 9: 465-78. PMID 1524827 DOI: 10.1016/0896-6273(92)90184-F |
0.546 |
|
| 1992 |
Holtzman DM, Li Y, Gage FH, Epstein CJ, Mobley WC. Neurodegeneration and gene dysregulation: studies utilizing the mouse trisomy 16 model of Down syndrome. Progress in Clinical and Biological Research. 379: 227-44. PMID 1409747 |
0.387 |
|
| 1992 |
Holtzman DM, Bayney RM, Li YW, Khosrovi H, Berger CN, Epstein CJ, Mobley WC. Dysregulation of gene expression in mouse trisomy 16, an animal model of Down syndrome. The Embo Journal. 11: 619-27. PMID 1371464 DOI: 10.1002/J.1460-2075.1992.Tb05094.X |
0.447 |
|
| 1991 |
Koliatsos VE, Applegate MD, Knüsel B, Junard EO, Burton LE, Mobley WC, Hefti FF, Price DL. Recombinant human nerve growth factor prevents retrograde degeneration of axotomized basal forebrain cholinergic neurons in the rat. Experimental Neurology. 112: 161-73. PMID 2037030 DOI: 10.1016/0014-4886(91)90066-L |
0.42 |
|
| 1991 |
Fahnestock M, Woo JE, Lopez GA, Snow J, Walz DA, Arici MJ, Mobley WC. beta-NGF-endopeptidase: structure and activity of a kallikrein encoded by the gene mGK-22. Biochemistry. 30: 3443-50. PMID 2012805 DOI: 10.1021/Bi00228A014 |
0.326 |
|
| 1991 |
Gold BG, Mobley WC, Matheson SF. Regulation of axonal caliber, neurofilament content, and nuclear localization in mature sensory neurons by nerve growth factor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 11: 943-55. PMID 2010817 DOI: 10.1523/Jneurosci.11-04-00943.1991 |
0.371 |
|
| 1991 |
Holtzman DM, Mobley WC. Molecular studies in Alzheimer's disease. Trends in Biochemical Sciences. 16: 140-4. PMID 1877089 DOI: 10.1016/0968-0004(91)90056-2 |
0.446 |
|
| 1991 |
Koliatsos VE, Shelton DL, Mobley WC, Price DL. A novel group of nerve growth factor receptor-immunoreactive neurons in the ventral horn of the lumbar spinal cord. Brain Research. 541: 121-8. PMID 1851446 DOI: 10.1016/0006-8993(91)91084-E |
0.352 |
|
| 1991 |
Holtzman DM, Li YW, Gage FH, DeArmond SJ, Epstein CJ, McKinley MP, Mobley WC. Modeling cholinergic abnormalities in Down syndrome and Alzheimer's disease. Progress in Clinical and Biological Research. 373: 189-202. PMID 1838184 |
0.411 |
|
| 1991 |
Koliatsos VE, Clatterbuck RE, Nauta HJ, Knüsel B, Burton LE, Hefti FF, Mobley WC, Price DL. Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates. Annals of Neurology. 30: 831-40. PMID 1789695 DOI: 10.1002/Ana.410300613 |
0.435 |
|
| 1991 |
Taiwo YO, Levine JD, Burch RM, Woo JE, Mobley WC. Hyperalgesia induced in the rat by the amino-terminal octapeptide of nerve growth factor. Proceedings of the National Academy of Sciences of the United States of America. 88: 5144-8. PMID 1647026 DOI: 10.1073/Pnas.88.12.5144 |
0.378 |
|
| 1990 |
Koliatsos VE, Nauta HJ, Clatterbuck RE, Holtzman DM, Mobley WC, Price DL. Mouse nerve growth factor prevents degeneration of axotomized basal forebrain cholinergic neurons in the monkey. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 3801-13. PMID 2269884 DOI: 10.1523/Jneurosci.10-12-03801.1990 |
0.545 |
|
| 1990 |
Knüsel B, Burton LE, Longo FM, Mobley WC, Koliatsos VE, Price DL, Hefti F. Trophic actions of recombinant human nerve growth factor on cultured rat embryonic CNS cells. Experimental Neurology. 110: 274-83. PMID 2249737 DOI: 10.1016/0014-4886(90)90039-U |
0.388 |
|
| 1990 |
Longo FM, Vu TK, Mobley WC. The in vitro biological effect of nerve growth factor is inhibited by synthetic peptides. Cell Regulation. 1: 189-95. PMID 2100197 DOI: 10.1091/Mbc.1.2.189 |
0.37 |
|
| 1990 |
McKinley MP, Longo FM, Valletta JS, Rahbar F, Neve RL, Prusiner SB, Mobley WC. Nerve growth factor induces gene expression of the prion protein and beta-amyloid protein precursor in the developing hamster central nervous system. Progress in Brain Research. 86: 227-38. PMID 1982367 DOI: 10.1016/S0079-6123(08)63180-5 |
0.418 |
|
| 1989 |
Mobley WC. Nerve growth factor in Alzheimer's disease: to treat or not to treat? Neurobiology of Aging. 10: 578-80; discussion 5. PMID 2812231 DOI: 10.1016/0197-4580(89)90135-8 |
0.399 |
|
| 1989 |
Saffran BN, Woo JE, Mobley WC, Crutcher KA. Intraventricular NGF infusion in the mature rat brain enhances sympathetic innervation of cerebrovascular targets but fails to elicit sympathetic ingrowth. Brain Research. 492: 245-54. PMID 2752299 DOI: 10.1016/0006-8993(89)90907-4 |
0.388 |
|
| 1989 |
Hsiang J, Heller A, Hoffmann PC, Mobley WC, Wainer BH. The effects of nerve growth factor on the development of septal cholinergic neurons in reaggregate cell cultures. Neuroscience. 29: 209-23. PMID 2710345 DOI: 10.1016/0306-4522(89)90344-8 |
0.38 |
|
| 1989 |
Phelps CH, Gage FH, Growdon JH, Hefti F, Harbaugh R, Johnston MV, Khachaturian ZS, Mobley WC, Price DL, Raskind M. Potential use of nerve growth factor to treat Alzheimer's disease. Neurobiology of Aging. 10: 205-7. PMID 2657468 DOI: 10.1016/0197-4580(89)90032-8 |
0.337 |
|
| 1989 |
Mobley WC, Woo JE, Edwards RH, Riopelle RJ, Longo FM, Weskamp G, Otten U, Valletta JS, Johnston MV. Developmental regulation of nerve growth factor and its receptor in the rat caudate-putamen. Neuron. 3: 655-64. PMID 2561975 DOI: 10.1016/0896-6273(89)90276-6 |
0.419 |
|
| 1989 |
McKinley MP, DeArmond SJ, Torchia M, Mobley WC, Prusiner SB. Acceleration of scrapie in neonatal Syrian hamsters. Neurology. 39: 1319-24. PMID 2507957 DOI: 10.1212/Wnl.39.10.1319 |
0.327 |
|
| 1988 |
Edwards RH, Selby MJ, Mobley WC, Weinrich SL, Hruby DE, Rutter WJ. Processing and secretion of nerve growth factor: expression in mammalian cells with a vaccinia virus vector. Molecular and Cellular Biology. 8: 2456-64. PMID 3405211 DOI: 10.1128/Mcb.8.6.2456 |
0.355 |
|
| 1988 |
Mobley WC, Neve RL, Prusiner SB, McKinley MP. Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain. Proceedings of the National Academy of Sciences of the United States of America. 85: 9811-5. PMID 2904679 DOI: 10.1073/Pnas.85.24.9811 |
0.372 |
|
| 1987 |
Johnston MV, Rutkowski JL, Wainer BH, Long JB, Mobley WC. NGF effects on developing forebrain cholinergic neurons are regionally specific. Neurochemical Research. 12: 985-94. PMID 3683745 DOI: 10.1007/Bf00970927 |
0.407 |
|
| 1986 |
Mobley WC, Rutkowski JL, Tennekoon GI, Gemski J, Buchanan K, Johnston MV. Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons. Brain Research. 387: 53-62. PMID 3742234 DOI: 10.1016/0169-328X(86)90020-3 |
0.418 |
|
| 1985 |
Kitt CA, Struble RG, Cork LC, Mobley WC, Walker LC, Joh TH, Price DL. Catecholaminergic neurites in senile plaques in prefrontal cortex of aged nonhuman primates. Neuroscience. 16: 691-9. PMID 2869445 DOI: 10.1016/0306-4522(85)90202-7 |
0.306 |
|
| 1985 |
Mobley WC, Rutkowski JL, Tennekoon GI, Buchanan K, Johnston MV. Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor. Science (New York, N.Y.). 229: 284-7. PMID 2861660 DOI: 10.1126/Science.2861660 |
0.407 |
|
| 1984 |
Kitt CA, Price DL, Struble RG, Cork LC, Wainer BH, Becher MW, Mobley WC. Evidence for cholinergic neurites in senile plaques. Science (New York, N.Y.). 226: 1443-5. PMID 6505701 DOI: 10.1126/Science.6505701 |
0.328 |
|
| 1977 |
Mobley WC, Server AC, Ishii DN, Riopelle RJ, Shooter EM. Nerve growth factor (third of three parts). The New England Journal of Medicine. 297: 1211-8. PMID 411033 DOI: 10.1056/Nejm197712012972205 |
0.534 |
|
| 1977 |
Mobley WC, Server AC, Ishii DN, Riopelle RJ, Shooter EM. Nerve growth factor (first of three parts). The New England Journal of Medicine. 297: 1096-104. PMID 333290 DOI: 10.1056/Nejm197711172972005 |
0.534 |
|
| 1977 |
Mobley WC, Server AC, Ishii DN, Riopelle RJ, Shooter EM. Nerve growth factor (second of three parts). The New England Journal of Medicine. 297: 1149-58. PMID 72356 DOI: 10.1056/NEJM197711242972105 |
0.479 |
|
| 1976 |
Mobley WC, Schenker A, Shooter EM. Characterization and isolation of proteolytically modified nerve growth factor. Biochemistry. 15: 5543-52. PMID 999827 DOI: 10.1021/Bi00670A019 |
0.532 |
|
| 1975 |
Bjerre B, Björklund A, Mobley W, Rosengren E. Short- and long-term effects of nerve growth factor on the sympathetic nervous system in the adult mouse. Brain Research. 94: 263-77. PMID 1148872 DOI: 10.1016/0006-8993(75)90061-X |
0.381 |
|
| 1974 |
Moore JB, Mobley WC, Shooter EM. Proteolytic modification of the beta nerve growth factor protein. Biochemistry. 13: 833-40. PMID 4811070 DOI: 10.1021/Bi00701A030 |
0.523 |
|
| 1974 |
Bjerre B, Björklund A, Mobley W. A stimulatory effect by nerve growth factor on the regrowth of adrenergic nerve fibres in the mouse peripheral tissues after chemical sympathectomy with 6-hydroxydopamine. Zeitschrift Fur Zellforschung Und Mikroskopische Anatomie (Vienna, Austria : 1948). 146: 15-43. PMID 4777497 DOI: 10.1007/Bf00306757 |
0.393 |
|
| 1974 |
Stenevi U, Bjerre B, Björklund A, Mobley W. Effects of localized intracerebral injections of nerve growth factor on the regenerative growth of lesioned central noradrenergic neurones. Brain Research. 69: 217-34. PMID 4406332 DOI: 10.1016/0006-8993(74)90003-1 |
0.392 |
|
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