Neil L. Harrison - Publications

Affiliations: 
Columbia University, New York, NY 
 University of California, San Francisco, San Francisco, CA 
 University of Chicago, Chicago, IL 
 Weill Cornell Medical College, New York, NY, United States 
Area:
GABA-A receptors

150 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Salling MC, Jane Skelly M, Avegno E, Regan S, Zeric T, Nichols E, Harrison NL. Alcohol consumption during adolescence in a mouse model of binge drinking alters the intrinsic excitability and function of the prefrontal cortex through a reduction in the hyperpolarization-activated cation current. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29915134 DOI: 10.1523/JNEUROSCI.0550-18.2018  0.92
2017 McCracken LM, Lowes DC, Salling MC, Carreau-Vollmer C, Odean NN, Blednov YA, Betz H, Harris RA, Harrison NL. Glycine receptor α3 and α2 subunits mediate tonic and exogenous agonist-induced currents in forebrain. Proceedings of the National Academy of Sciences of the United States of America. PMID 28784756 DOI: 10.1073/pnas.1703839114  0.92
2017 Harrison NL, Skelly MJ, Grosserode EP, Lowes DC, Zeric T, Phister S, Salling MC. Effects of acute alcohol on excitability in the CNS. Neuropharmacology. PMID 28479395 DOI: 10.1016/j.neuropharm.2017.04.007  0.92
2017 Yocum GT, Turner DL, Danielsson J, Barajas MB, Zhang Y, Xu D, Harrison N, Homanics GE, Farber DL, Emala CW. GABAA Receptor α4 Subunit Knockout Enhances Lung Inflammation and Airway Reactivity in a Murine Asthma Model. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00107.2017. PMID 28473323 DOI: 10.1152/ajplung.00107.2017  0.4
2016 Avegno EM, Salling MC, Borgkvist A, Mrejeru A, Whitebirch AC, Margolis EB, Sulzer D, Harrison NL. Voluntary adolescent drinking enhances excitation by low levels of alcohol in a subset of dopaminergic neurons in the ventral tegmental area. Neuropharmacology. PMID 27475082 DOI: 10.1016/j.neuropharm.2016.07.031  0.92
2016 Canetta S, Bolkan S, Padilla-Coreano N, Song LJ, Sahn R, Harrison NL, Gordon JA, Brown A, Kellendonk C. Maternal immune activation does not alter the number of perisomatic parvalbumin-positive boutons in the offspring prefrontal cortex. Molecular Psychiatry. 21: 857. PMID 27321207 DOI: 10.1038/mp.2016.92  0.92
2016 Canetta S, Bolkan S, Padilla-Coreano N, Song LJ, Sahn R, Harrison NL, Gordon JA, Brown A, Kellendonk C. Maternal immune activation leads to selective functional deficits in offspring parvalbumin interneurons. Molecular Psychiatry. PMID 26830140 DOI: 10.1038/mp.2015.222  0.92
2015 Dixon CL, Harrison NL, Lynch JW, Keramidas A. Zolpidem and eszopiclone prime α1β2γ2 GABAA receptors for longer duration of activity. British Journal of Pharmacology. 172: 3522-36. PMID 25817320 DOI: 10.1111/bph.13142  0.76
2015 Mrejeru A, Martí-Prats L, Avegno EM, Harrison NL, Sulzer D. A subset of ventral tegmental area dopamine neurons responds to acute ethanol. Neuroscience. 290: 649-58. PMID 25660505 DOI: 10.1016/j.neuroscience.2014.12.081  1
2015 Gallo EF, Salling MC, Feng B, Morón JA, Harrison NL, Javitch JA, Kellendonk C. Upregulation of dopamine D2 receptors in the nucleus accumbens indirect pathway increases locomotion but does not reduce alcohol consumption. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1609-18. PMID 25578797 DOI: 10.1038/npp.2015.11  0.92
2014 Salling MC, Harrison NL. Strychnine-sensitive glycine receptors on pyramidal neurons in layers II/III of the mouse prefrontal cortex are tonically activated. Journal of Neurophysiology. 112: 1169-78. PMID 24872538 DOI: 10.1152/jn.00714.2013  0.92
2013 Varodayan FP, Harrison NL. HSF1 transcriptional activity mediates alcohol induction of Vamp2 expression and GABA release. Frontiers in Integrative Neuroscience. 7: 89. PMID 24376402 DOI: 10.3389/fnint.2013.00089  0.88
2013 Pignataro L, Varodayan FP, Tannenholz LE, Protiva P, Harrison NL. Brief alcohol exposure alters transcription in astrocytes via the heat shock pathway. Brain and Behavior. 3: 114-33. PMID 23533150 DOI: 10.1002/brb3.125  1
2013 Mintz CD, Barrett KM, Smith SC, Benson DL, Harrison NL. Anesthetics interfere with axon guidance in developing mouse neocortical neurons in vitro via a γ-aminobutyric acid type A receptor mechanism. Anesthesiology. 118: 825-33. PMID 23364597 DOI: 10.1097/ALN.0b013e318287b850  1
2012 Ganat YM, Calder EL, Kriks S, Nelander J, Tu EY, Jia F, Battista D, Harrison N, Parmar M, Tomishima MJ, Rutishauser U, Studer L. Identification of embryonic stem cell-derived midbrain dopaminergic neurons for engraftment. The Journal of Clinical Investigation. 122: 2928-39. PMID 22751106 DOI: 10.1172/JCI58767  1
2012 Cazorla M, Shegda M, Ramesh B, Harrison NL, Kellendonk C. Striatal D2 receptors regulate dendritic morphology of medium spiny neurons via Kir2 channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 2398-409. PMID 22396414 DOI: 10.1523/JNEUROSCI.6056-11.2012  1
2011 Varodayan FP, Pignataro L, Harrison NL. Alcohol induces synaptotagmin 1 expression in neurons via activation of heat shock factor 1. Neuroscience. 193: 63-71. PMID 21816209 DOI: 10.1016/j.neuroscience.2011.07.035  1
2011 Blednov YA, Borghese CM, McCracken ML, Benavidez JM, Geil CR, Osterndorff-Kahanek E, Werner DF, Iyer S, Swihart A, Harrison NL, Homanics GE, Harris RA. Loss of ethanol conditioned taste aversion and motor stimulation in knockin mice with ethanol-insensitive α2-containing GABA(A) receptors. The Journal of Pharmacology and Experimental Therapeutics. 336: 145-54. PMID 20876231 DOI: 10.1124/jpet.110.171645  1
2011 Werner DF, Swihart A, Rau V, Jia F, Borghese CM, McCracken ML, Iyer S, Fanselow MS, Oh I, Sonner JM, Eger EI, Harrison NL, Harris RA, Homanics GE. Inhaled anesthetic responses of recombinant receptors and knockin mice harboring α2(S270H/L277A) GABA(A) receptor subunits that are resistant to isoflurane. The Journal of Pharmacology and Experimental Therapeutics. 336: 134-44. PMID 20807777 DOI: 10.1124/jpet.110.170431  1
2010 Keramidas A, Harrison NL. The activation mechanism of alpha1beta2gamma2S and alpha3beta3gamma2S GABAA receptors. The Journal of General Physiology. 135: 59-75. PMID 20038526 DOI: 10.1085/jgp.200910317  1
2009 Placantonakis DG, Tomishima MJ, Lafaille F, Desbordes SC, Jia F, Socci ND, Viale A, Lee H, Harrison N, Studer L, Tabar VS. Enriched motor neuron populations derived from bacterial artificial chromosome-transgenic human embryonic stem cells. Clinical Neurosurgery. 56: 125-32. PMID 20214043  1
2009 Rau V, Iyer SV, Oh I, Chandra D, Harrison N, Eger EI, Fanselow MS, Homanics GE, Sonner JM. Gamma-aminobutyric acid type A receptor alpha 4 subunit knockout mice are resistant to the amnestic effect of isoflurane. Anesthesia and Analgesia. 109: 1816-22. PMID 19923508 DOI: 10.1213/ANE.0b013e3181bf6ae6  1
2009 Belelli D, Harrison NL, Maguire J, Macdonald RL, Walker MC, Cope DW. Extrasynaptic GABAA receptors: form, pharmacology, and function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12757-63. PMID 19828786 DOI: 10.1523/JNEUROSCI.3340-09.2009  1
2009 Pignataro L, Varodayan FP, Tannenholz LE, Harrison NL. The regulation of neuronal gene expression by alcohol. Pharmacology & Therapeutics. 124: 324-35. PMID 19781570 DOI: 10.1016/j.pharmthera.2009.09.002  1
2009 Placantonakis DG, Tomishima MJ, Lafaille F, Desbordes SC, Jia F, Socci ND, Viale A, Lee H, Harrison N, Tabar V, Studer L. BAC transgenesis in human embryonic stem cells as a novel tool to define the human neural lineage. Stem Cells (Dayton, Ohio). 27: 521-32. PMID 19074416 DOI: 10.1634/stemcells.2008-0884  1
2009 Jia F, Goldstein PA, Harrison NL. The modulation of synaptic GABA(A) receptors in the thalamus by eszopiclone and zolpidem. The Journal of Pharmacology and Experimental Therapeutics. 328: 1000-6. PMID 19033556 DOI: 10.1124/jpet.108.146084  1
2009 Werner DF, Swihart AR, Ferguson C, Lariviere WR, Harrison NL, Homanics GE. Alcohol-induced tolerance and physical dependence in mice with ethanol insensitive alpha1 GABA A receptors. Alcoholism, Clinical and Experimental Research. 33: 289-99. PMID 19032579 DOI: 10.1111/j.1530-0277.2008.00832.x  1
2009 Ying SW, Werner DF, Homanics GE, Harrison NL, Goldstein PA. Isoflurane modulates excitability in the mouse thalamus via GABA-dependent and GABA-independent mechanisms. Neuropharmacology. 56: 438-47. PMID 18948126 DOI: 10.1016/j.neuropharm.2008.09.015  1
2008 Harrison N, Nau C. Sensitization of nociceptive ion channels by inhaled anesthetics--a pain in the gas? Molecular Pharmacology. 74: 1180-2. PMID 18768735 DOI: 10.1124/mol.108.051615  1
2008 Jia F, Chandra D, Homanics GE, Harrison NL. Ethanol modulates synaptic and extrasynaptic GABAA receptors in the thalamus. The Journal of Pharmacology and Experimental Therapeutics. 326: 475-82. PMID 18477766 DOI: 10.1124/jpet.108.139303  1
2008 Keramidas A, Harrison NL. Agonist-dependent single channel current and gating in alpha4beta2delta and alpha1beta2gamma2S GABAA receptors. The Journal of General Physiology. 131: 163-81. PMID 18227274 DOI: 10.1085/jgp.200709871  1
2008 Trudell JR, Yue ME, Bertaccini EJ, Jenkins A, Harrison NL. Molecular modeling and mutagenesis reveals a tetradentate binding site for Zn2+ in GABA(A) alphabeta receptors and provides a structural basis for the modulating effect of the gamma subunit. Journal of Chemical Information and Modeling. 48: 344-9. PMID 18197653 DOI: 10.1021/ci700324a  1
2008 Jia F, Yue M, Chandra D, Keramidas A, Goldstein PA, Homanics GE, Harrison NL. Taurine is a potent activator of extrasynaptic GABA(A) receptors in the thalamus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 106-15. PMID 18171928 DOI: 10.1523/JNEUROSCI.3996-07.2008  1
2008 Jia F, Yue M, Chandra D, Homanics GE, Goldstein PA, Harrison NL. Isoflurane is a potent modulator of extrasynaptic GABA(A) receptors in the thalamus. The Journal of Pharmacology and Experimental Therapeutics. 324: 1127-35. PMID 18094320 DOI: 10.1124/jpet.107.134569  1
2008 Chandra D, Werner DF, Liang J, Suryanarayanan A, Harrison NL, Spigelman I, Olsen RW, Homanics GE. Normal acute behavioral responses to moderate/high dose ethanol in GABAA receptor alpha 4 subunit knockout mice. Alcoholism, Clinical and Experimental Research. 32: 10-8. PMID 18076749 DOI: 10.1111/j.1530-0277.2007.00563.x  1
2007 Pignataro L, Miller AN, Ma L, Midha S, Protiva P, Herrera DG, Harrison NL. Alcohol regulates gene expression in neurons via activation of heat shock factor 1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 12957-66. PMID 18032669 DOI: 10.1523/JNEUROSCI.4142-07.2007  1
2007 Harrison NL. Mechanisms of sleep induction by GABA(A) receptor agonists. The Journal of Clinical Psychiatry. 68: 6-12. PMID 17539703  1
2007 Jia F, Pignataro L, Harrison NL. GABAA receptors in the thalamus: alpha4 subunit expression and alcohol sensitivity. Alcohol (Fayetteville, N.Y.). 41: 177-85. PMID 17521848 DOI: 10.1016/j.alcohol.2007.03.010  1
2007 Sonner JM, Werner DF, Elsen FP, Xing Y, Liao M, Harris RA, Harrison NL, Fanselow MS, Eger EI, Homanics GE. Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isoflurane. Anesthesiology. 106: 107-13. PMID 17197852 DOI: 10.1097/00000542-200701000-00019  1
2006 Chandra D, Jia F, Liang J, Peng Z, Suryanarayanan A, Werner DF, Spigelman I, Houser CR, Olsen RW, Harrison NL, Homanics GE. GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol. Proceedings of the National Academy of Sciences of the United States of America. 103: 15230-5. PMID 17005728 DOI: 10.1073/pnas.0604304103  1
2006 Borghese CM, Werner DF, Topf N, Baron NV, Henderson LA, Boehm SL, Blednov YA, Saad A, Dai S, Pearce RA, Harris RA, Homanics GE, Harrison NL. An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin mice. The Journal of Pharmacology and Experimental Therapeutics. 319: 208-18. PMID 16807363 DOI: 10.1124/jpet.106.104406  1
2006 Werner DF, Blednov YA, Ariwodola OJ, Silberman Y, Logan E, Berry RB, Borghese CM, Matthews DB, Weiner JL, Harrison NL, Harris RA, Homanics GE. Knockin mice with ethanol-insensitive alpha1-containing gamma-aminobutyric acid type A receptors display selective alterations in behavioral responses to ethanol. The Journal of Pharmacology and Experimental Therapeutics. 319: 219-27. PMID 16785315 DOI: 10.1124/jpet.106.106161  1
2006 Keramidas A, Kash TL, Harrison NL. The pre-M1 segment of the alpha1 subunit is a transduction element in the activation of the GABAA receptor. The Journal of Physiology. 575: 11-22. PMID 16763005 DOI: 10.1113/jphysiol.2005.102756  1
2006 Elsen FP, Liljelund P, Werner DF, Olsen RW, Homanics GE, Harrison NL. GABA(A)-R alpha1 subunit knockin mutation leads to abnormal EEG and anesthetic-induced seizure-like activity in mice. Brain Research. 1078: 60-70. PMID 16490182 DOI: 10.1016/j.brainres.2006.01.036  1
2006 Ying SW, Abbas SY, Harrison NL, Goldstein PA. Propofol block of I(h) contributes to the suppression of neuronal excitability and rhythmic burst firing in thalamocortical neurons. The European Journal of Neuroscience. 23: 465-80. PMID 16420453 DOI: 10.1111/j.1460-9568.2005.04587.x  1
2006 Harrison NL. General anesthetics: Mechanisms of action Foundations of Anesthesia. 287-294. DOI: 10.1016/B978-0-323-03707-5.50030-9  1
2005 Jia F, Pignataro L, Schofield CM, Yue M, Harrison NL, Goldstein PA. An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons. Journal of Neurophysiology. 94: 4491-501. PMID 16162835 DOI: 10.1152/jn.00421.2005  1
2005 Hemmings HC, Akabas MH, Goldstein PA, Trudell JR, Orser BA, Harrison NL. Emerging molecular mechanisms of general anesthetic action. Trends in Pharmacological Sciences. 26: 503-10. PMID 16126282 DOI: 10.1016/j.tips.2005.08.006  1
2005 Cacheaux LP, Topf N, Tibbs GR, Schaefer UR, Levi R, Harrison NL, Abbott GW, Goldstein PA. Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol. The Journal of Pharmacology and Experimental Therapeutics. 315: 517-25. PMID 16033909 DOI: 10.1124/jpet.105.091801  1
2005 Sonner JM, Vissel B, Royle G, Maurer A, Gong D, Baron NV, Harrison N, Fanselow M, Eger EI. The effect of three inhaled anesthetics in mice harboring mutations in the GluR6 (kainate) receptor gene. Anesthesia and Analgesia. 101: 143-8, table of cont. PMID 15976221 DOI: 10.1213/01.ANE.0000152615.53435.B4  1
2005 Hall AC, Stevens RJ, Betts BA, Yeung WY, Kelley JC, Harrison NL. Subunit-dependent block by isoflurane of wild-type and mutant alpha(1)S270H GABA(A) receptor currents in Xenopus oocytes. Neuroscience Letters. 382: 332-7. PMID 15925114 DOI: 10.1016/j.neulet.2005.03.029  1
2005 Schofield CM, Harrison NL. Transmembrane residues define the action of isoflurane at the GABAA receptor alpha-3 subunit. Brain Research. 1032: 30-5. PMID 15680938 DOI: 10.1016/j.brainres.2004.11.002  1
2005 Homanics GE, Elsen FP, Ying SW, Jenkins A, Ferguson C, Sloat B, Yuditskaya S, Goldstein PA, Kralic JE, Morrow AL, Harrison NL. A gain-of-function mutation in the GABA receptor produces synaptic and behavioral abnormalities in the mouse. Genes, Brain, and Behavior. 4: 10-9. PMID 15660664 DOI: 10.1111/j.1601-183X.2004.00090.x  1
2005 Jenkins A, Kash TL, Schofield CM, Trudell JR, Harrison NL. Structural elements governing activation and modulation of GABAA receptors International Congress Series. 1283: 26-31. DOI: 10.1016/j.ics.2005.07.075  1
2004 Kash TL, Kim T, Trudell JR, Harrison NL. Evaluation of a proposed mechanism of ligand-gated ion channel activation in the GABAA and glycine receptors. Neuroscience Letters. 371: 230-4. PMID 15519763 DOI: 10.1016/j.neulet.2004.09.002  1
2004 Perrier AL, Tabar V, Barberi T, Rubio ME, Bruses J, Topf N, Harrison NL, Studer L. Derivation of midbrain dopamine neurons from human embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 12543-8. PMID 15310843 DOI: 10.1073/pnas.0404700101  1
2004 Schofield CM, Trudell JR, Harrison NL. Alanine-scanning mutagenesis in the signature disulfide loop of the glycine receptor alpha 1 subunit: critical residues for activation and modulation. Biochemistry. 43: 10058-63. PMID 15287733 DOI: 10.1021/bi036159g  1
2004 Ma L, Song L, Radoi GE, Harrison NL. Transcriptional regulation of the mouse gene encoding the alpha-4 subunit of the GABAA receptor. The Journal of Biological Chemistry. 279: 40451-61. PMID 15265862 DOI: 10.1074/jbc.M406827200  1
2004 Kash TL, Trudell JR, Harrison NL. Structural elements involved in activation of the gamma-aminobutyric acid type A (GABAA) receptor. Biochemical Society Transactions. 32: 540-6. PMID 15157180 DOI: 10.1042/BST0320540  1
2004 Hall AC, Rowan KC, Stevens RJ, Kelley JC, Harrison NL. The effects of isoflurane on desensitized wild-type and alpha 1(S270H) gamma-aminobutyric acid type A receptors. Anesthesia and Analgesia. 98: 1297-304, table of c. PMID 15105205  1
2004 Castaldo P, Stefanoni P, Miceli F, Coppola G, Del Giudice EM, Bellini G, Pascotto A, Trudell JR, Harrison NL, Annunziato L, Taglialatela M. A novel hyperekplexia-causing mutation in the pre-transmembrane segment 1 of the human glycine receptor alpha1 subunit reduces membrane expression and impairs gating by agonists. The Journal of Biological Chemistry. 279: 25598-604. PMID 15066993 DOI: 10.1074/jbc.M311021200  1
2004 Kash TL, Dizon MJ, Trudell JR, Harrison NL. Charged residues in the beta2 subunit involved in GABAA receptor activation. The Journal of Biological Chemistry. 279: 4887-93. PMID 14610076 DOI: 10.1074/jbc.M311441200  1
2003 Barberi T, Klivenyi P, Calingasan NY, Lee H, Kawamata H, Loonam K, Perrier AL, Bruses J, Rubio ME, Topf N, Tabar V, Harrison NL, Beal MF, Moore MA, Studer L. Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice. Nature Biotechnology. 21: 1200-7. PMID 14502203 DOI: 10.1038/nbt870  1
2003 Nishikawa K, Harrison NL. The actions of sevoflurane and desflurane on the gamma-aminobutyric acid receptor type A: effects of TM2 mutations in the alpha and beta subunits. Anesthesiology. 99: 678-84. PMID 12960553 DOI: 10.1097/00000542-200309000-00024  1
2003 Harrison NL. Knockin' on the door of general anesthetic mechanisms: but will U.S. researchers be shut out? Anesthesia and Analgesia. 97: 616-8. PMID 12933370  1
2003 Schofield CM, Jenkins A, Harrison NL. A highly conserved aspartic acid residue in the signature disulfide loop of the alpha 1 subunit is a determinant of gating in the glycine receptor. The Journal of Biological Chemistry. 278: 34079-83. PMID 12826676 DOI: 10.1074/jbc.M302416200  1
2003 Ruscito BJ, Harrison NL. Hemoglobin metabolites mimic benzodiazepines and are possible mediators of hepatic encephalopathy. Blood. 102: 1525-8. PMID 12714506 DOI: 10.1182/blood-2003-03-0739  1
2003 Topf N, Jenkins A, Baron N, Harrison NL. Effects of isoflurane on gamma-aminobutyric acid type A receptors activated by full and partial agonists. Anesthesiology. 98: 306-11. PMID 12552186 DOI: 10.1097/00000542-200302000-00007  1
2003 Kash TL, Jenkins A, Kelley JC, Trudell JR, Harrison NL. Coupling of agonist binding to channel gating in the GABA(A) receptor. Nature. 421: 272-5. PMID 12529644 DOI: 10.1038/nature01280  1
2003 Kash TL, Jenkins A, Harrison NL. Molecular volume determines the activity of the halogenated alkane bromoform at wild-type and mutant GABA(A) receptors. Brain Research. 960: 36-41. PMID 12505655 DOI: 10.1016/S0006-8993(02)03748-4  1
2002 Goldstein PA, Elsen FP, Ying SW, Ferguson C, Homanics GE, Harrison NL. Prolongation of hippocampal miniature inhibitory postsynaptic currents in mice lacking the GABA(A) receptor alpha1 subunit. Journal of Neurophysiology. 88: 3208-17. PMID 12466441 DOI: 10.1152/jn.00885.2001  1
2002 Jenkins A, Andreasen A, Trudell JR, Harrison NL. Tryptophan scanning mutagenesis in TM4 of the GABA(A) receptor alpha1 subunit: implications for modulation by inhaled anesthetics and ion channel structure. Neuropharmacology. 43: 669-78. PMID 12367612 DOI: 10.1016/S0028-3908(02)00175-2  1
2002 Harrison NL. General anesthesia research: aroused from a deep sleep? Nature Neuroscience. 5: 928-9. PMID 12352979 DOI: 10.1038/nn1002-928  1
2002 Krasowski MD, Hong X, Hopfinger AJ, Harrison NL. 4D-QSAR analysis of a set of propofol analogues: mapping binding sites for an anesthetic phenol on the GABA(A) receptor. Journal of Medicinal Chemistry. 45: 3210-21. PMID 12109905 DOI: 10.1021/jm010461a  1
2002 Nishikawa K, Jenkins A, Paraskevakis I, Harrison NL. Volatile anesthetic actions on the GABAA receptors: contrasting effects of alpha 1(S270) and beta 2(N265) point mutations. Neuropharmacology. 42: 337-45. PMID 11897112 DOI: 10.1016/S0028-3908(01)00189-7  1
2001 Krasowski MD, Nishikawa K, Nikolaeva N, Lin A, Harrison NL. Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics. Neuropharmacology. 41: 952-64. PMID 11747900 DOI: 10.1016/S0028-3908(01)00141-1  1
2001 Kung AY, Rick C, O'Shea S, Harrison NL, McGehee DS. Expression of glycine receptors in rat sensory neurons vs. HEK293 cells yields different functional properties. Neuroscience Letters. 309: 202-6. PMID 11514076 DOI: 10.1016/S0304-3940(01)02066-3  1
2001 Lingamaneni R, Krasowski MD, Jenkins A, Truong T, Giunta AL, Blackbeer J, MacIver MB, Harrison NL, Hemmings HC. Anesthetic properties of 4-iodopropofol: implications for mechanisms of anesthesia. Anesthesiology. 94: 1050-7. PMID 11465597  1
2001 Findlay GS, Ueno S, Harrison NL, Harris RA. Allosteric modulation in spontaneously active mutant gamma-aminobutyric acidA receptors. Neuroscience Letters. 305: 77-80. PMID 11356312  1
2001 Krasowski MD, Jenkins A, Flood P, Kung AY, Hopfinger AJ, Harrison NL. General anesthetic potencies of a series of propofol analogs correlate with potency for potentiation of gamma-aminobutyric acid (GABA) current at the GABA(A) receptor but not with lipid solubility. The Journal of Pharmacology and Experimental Therapeutics. 297: 338-51. PMID 11259561  1
2001 Jenkins A, Greenblatt EP, Faulkner HJ, Bertaccini E, Light A, Lin A, Andreasen A, Viner A, Trudell JR, Harrison NL. Evidence for a common binding cavity for three general anesthetics within the GABAA receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: RC136. PMID 11245705  1
2000 Findlay GS, Ueno S, Harrison NL, Harris RA. Allosteric modulation in spontaneously active mutant gamma-aminobutyric acid(A) receptors [corrected]. Neuroscience Letters. 293: 155-8. PMID 11036184 DOI: 10.1016/S0304-3940(00)01503-2  1
2000 Ueno S, Lin A, Nikolaeva N, Trudell JR, Mihic SJ, Harris RA, Harrison NL. Tryptophan scanning mutagenesis in TM2 of the GABA(A) receptor alpha subunit: effects on channel gating and regulation by ethanol. British Journal of Pharmacology. 131: 296-302. PMID 10991923 DOI: 10.1038/sj.bjp.0703504  1
2000 O'Shea SM, Harrison NL. Arg-274 and Leu-277 of the gamma-aminobutyric acid type A receptor alpha 2 subunit define agonist efficacy and potency. The Journal of Biological Chemistry. 275: 22764-8. PMID 10801806 DOI: 10.1074/jbc.M001299200  1
2000 Harrison NL. Ion channels take center stage: twin spotlights on two anesthetic targets. Anesthesiology. 92: 936-8. PMID 10754611  1
2000 Krasowski MD, Harrison NL. The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations. British Journal of Pharmacology. 129: 731-43. PMID 10683198 DOI: 10.1038/sj.bjp.0703087  1
2000 O'Shea SM, Wong LC, Harrison NL. Propofol increases agonist efficacy at the GABA(A) receptor. Brain Research. 852: 344-8. PMID 10678761 DOI: 10.1016/S0006-8993(99)02151-4  1
1999 Koltchine VV, Finn SE, Jenkins A, Nikolaeva N, Lin A, Harrison NL. Agonist gating and isoflurane potentiation in the human gamma-aminobutyric acid type A receptor determined by the volume of a second transmembrane domain residue. Molecular Pharmacology. 56: 1087-93. PMID 10531417  1
1999 Krasowski MD, Harrison NL. General anaesthetic actions on ligand-gated ion channels. Cellular and Molecular Life Sciences : Cmls. 55: 1278-303. PMID 10487207 DOI: 10.1007/s000180050371  1
1999 Ueno S, Wick MJ, Ye Q, Harrison NL, Harris RA. Subunit mutations affect ethanol actions on GABA(A) receptors expressed in Xenopus oocytes. British Journal of Pharmacology. 127: 377-82. PMID 10385236 DOI: 10.1038/sj.bjp.0702563  1
1999 Homanics GE, Harrison NL, Quinlan JJ, Krasowski MD, Rick CE, de Blas AL, Mehta AK, Kist F, Mihalek RM, Aul JJ, Firestone LL. Normal electrophysiological and behavioral responses to ethanol in mice lacking the long splice variant of the gamma2 subunit of the gamma-aminobutyrate type A receptor. Neuropharmacology. 38: 253-65. PMID 10218866 DOI: 10.1016/S0028-3908(98)00177-4  1
1998 Wick MJ, Mihic SJ, Ueno S, Mascia MP, Trudell JR, Brozowski SJ, Ye Q, Harrison NL, Harris RA. Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor? Proceedings of the National Academy of Sciences of the United States of America. 95: 6504-9. PMID 9600996 DOI: 10.1073/pnas.95.11.6504  1
1998 Harrison NL. Optical isomers open a new window on anesthetic mechanism. Anesthesiology. 88: 566-8. PMID 9523796 DOI: 10.1097/00000542-199803000-00003  1
1998 Rick CE, Ye Q, Finn SE, Harrison NL. Neurosteroids act on the GABA(A) receptor at sites on the N-terminal side of the middle of TM2. Neuroreport. 9: 379-83. PMID 9512375  1
1998 Krasowski MD, Finn SE, Ye Q, Harrison NL. Trichloroethanol modulation of recombinant GABAA, glycine and GABA rho 1 receptors. The Journal of Pharmacology and Experimental Therapeutics. 284: 934-42. PMID 9495852  1
1998 Krasowski MD, Koltchine VV, Rick CE, Ye Q, Finn SE, Harrison NL. Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isoflurane. Molecular Pharmacology. 53: 530-8. PMID 9495821  1
1998 Krasowski MD, Rick CE, Harrison NL, Firestone LL, Homanics GE. A deficit of functional GABA(A) receptors in neurons of beta 3 subunit knockout mice. Neuroscience Letters. 240: 81-4. PMID 9486477 DOI: 10.1016/S0304-3940(97)00929-4  1
1998 Ye Q, Koltchine VV, Mihic SJ, Mascia MP, Wick MJ, Finn SE, Harrison NL, Harris RA. Enhancement of glycine receptor function by ethanol is inversely correlated with molecular volume at position alpha267. The Journal of Biological Chemistry. 273: 3314-9. PMID 9452448 DOI: 10.1074/jbc.273.6.3314  1
1997 Lavoie AM, Tingey JJ, Harrison NL, Pritchett DB, Twyman RE. Activation and deactivation rates of recombinant GABA(A) receptor channels are dependent on alpha-subunit isoform. Biophysical Journal. 73: 2518-26. PMID 9370445 DOI: 10.1016/S0006-3495(97)78280-8  1
1997 Mihic SJ, Ye Q, Wick MJ, Koltchine VV, Krasowski MD, Finn SE, Mascia MP, Valenzuela CF, Hanson KK, Greenblatt EP, Harris RA, Harrison NL. Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors. Nature. 389: 385-9. PMID 9311780 DOI: 10.1038/38738  1
1997 Krasowski MD, O'Shea SM, Rick CE, Whiting PJ, Hadingham KL, Czajkowski C, Harrison NL. Alpha subunit isoform influences GABA(A) receptor modulation by propofol. Neuropharmacology. 36: 941-9. PMID 9257938 DOI: 10.1016/S0028-3908(97)00074-9  1
1997 Homanics GE, DeLorey TM, Firestone LL, Quinlan JJ, Handforth A, Harrison NL, Krasowski MD, Rick CE, Korpi ER, Mäkelä R, Brilliant MH, Hagiwara N, Ferguson C, Snyder K, Olsen RW. Mice devoid of gamma-aminobutyrate type A receptor beta3 subunit have epilepsy, cleft palate, and hypersensitive behavior. Proceedings of the National Academy of Sciences of the United States of America. 94: 4143-8. PMID 9108119 DOI: 10.1073/pnas.94.8.4143  1
1996 Koltchine VV, Ye Q, Finn SE, Harrison NL. Chimeric GABAA/glycine receptors: expression and barbiturate pharmacology. Neuropharmacology. 35: 1445-56. PMID 9014160 DOI: 10.1016/S0028-3908(96)00088-3  1
1996 Gibbons SJ, Núñez-Hernández R, Mazé G, Harrison NL. Inhibition of a fast inwardly rectifying potassium conductance by barbiturates. Anesthesia and Analgesia. 82: 1242-6. PMID 8638798 DOI: 10.1097/00000539-199606000-00024  1
1995 Talukder G, Harrison NL. On the mechanism of modulation of transient outward current in cultured rat hippocampal neurons by di- and trivalent cations. Journal of Neurophysiology. 73: 73-9. PMID 7714591  1
1995 Jones MV, Harrison NL, Pritchett DB, Hales TG. Modulation of the GABAA receptor by propofol is independent of the gamma subunit. The Journal of Pharmacology and Experimental Therapeutics. 274: 962-8. PMID 7636760  1
1995 Bleakman D, Jones MV, Harrison NL. The effects of four general anesthetics on intracellular [Ca2+] in cultured rat hippocampal neurons. Neuropharmacology. 34: 541-51. PMID 7566489 DOI: 10.1016/0028-3908(95)00022-X  1
1994 Zimmerman SA, Jones MV, Harrison NL. Potentiation of gamma-aminobutyric acidA receptor Cl- current correlates with in vivo anesthetic potency. The Journal of Pharmacology and Experimental Therapeutics. 270: 987-91. PMID 7932211  1
1994 Harrison NL, Gibbons SJ. Zn2+: an endogenous modulator of ligand- and voltage-gated ion channels. Neuropharmacology. 33: 935-52. PMID 7845550 DOI: 10.1016/0028-3908(94)90152-X  1
1994 Bloomenthal AB, Goldwater E, Pritchett DB, Harrison NL. Biphasic modulation of the strychnine-sensitive glycine receptor by Zn2+. Molecular Pharmacology. 46: 1156-9. PMID 7808436  1
1993 Harrison NL, Radke HK, Tamkun MM, Lovinger DM. Modulation of gating of cloned rat and human K+ channels by micromolar Zn2+. Molecular Pharmacology. 43: 482-6. PMID 8450837  1
1993 Bleakman D, Roback JD, Wainer BH, Miller RJ, Harrison NL. Calcium homeostasis in rat septal neurons in tissue culture. Brain Research. 600: 257-67. PMID 8435751 DOI: 10.1016/0006-8993(93)91381-2  1
1993 Lovinger DM, Zimmerman SA, Levitin M, Jones MV, Harrison NL. Trichloroethanol potentiates synaptic transmission mediated by gamma-aminobutyric acidA receptors in hippocampal neurons. The Journal of Pharmacology and Experimental Therapeutics. 264: 1097-103. PMID 8383736  1
1993 Harrison NL, Radke HK, Talukder G, Ffrench-Mullen JM. Zinc modulates transient outward current gating in hippocampal neurons. Receptors & Channels. 1: 153-63. PMID 8081719  1
1993 Harrison NL, Kugler JL, Jones MV, Greenblatt EP, Pritchett DB. Positive modulation of human gamma-aminobutyric acid type A and glycine receptors by the inhalation anesthetic isoflurane. Molecular Pharmacology. 44: 628-32. PMID 7690453  1
1993 Jones MV, Harrison NL. Effects of volatile anesthetics on the kinetics of inhibitory postsynaptic currents in cultured rat hippocampal neurons. Journal of Neurophysiology. 70: 1339-49. PMID 7506753  1
1992 Bleakman D, Harrison NL, Colmers WF, Miller RJ. Investigations into neuropeptide Y-mediated presynaptic inhibition in cultured hippocampal neurones of the rat. British Journal of Pharmacology. 107: 334-40. PMID 1358389  1
1992 Lambert NA, Levitin M, Harrison NL. Induction of giant depolarizing potentials by zinc in area CA1 of the rat hippocampus does not result from block of GABAB receptors. Neuroscience Letters. 135: 215-8. PMID 1352630 DOI: 10.1016/0304-3940(92)90439-E  1
1992 Jones MV, Brooks PA, Harrison NL. Enhancement of gamma-aminobutyric acid-activated Cl- currents in cultured rat hippocampal neurones by three volatile anaesthetics. The Journal of Physiology. 449: 279-93. PMID 1326046 DOI: 10.1113/jphysiol.1992.sp019086  1
1992 Lovinger DM, Harrison NL, Lambert NA. The actions of 3-aminopropanephosphinic acid at GABAB receptors in rat hippocampus. European Journal of Pharmacology. 211: 337-41. PMID 1319911 DOI: 10.1016/0014-2999(92)90390-P  1
1992 Harrison NL, Brooks PA, Hornberger LA, Radke HK, Jones MV. The effects of some volatile anaesthetics on responses to exogenous GABA and inhibitory postsynaptic currents in cultured rat hippocampal neurons Journal of Physiology. 446: 258P.  1
1991 Lambert NA, Harrison NL, Teyler TJ. Baclofen-induced disinhibition in area CA1 of rat hippocampus is resistant to extracellular Ba2+. Brain Research. 547: 349-52. PMID 1679368 DOI: 10.1016/0006-8993(91)90985-5  1
1991 Lambert NA, Harrison NL, Teyler TJ. Evidence for mu opiate receptors on inhibitory terminals in area CA1 of rat hippocampus. Neuroscience Letters. 124: 101-4. PMID 1677456 DOI: 10.1016/0304-3940(91)90831-D  1
1990 Harrison NL. On the presynaptic action of baclofen at inhibitory synapses between cultured rat hippocampal neurones. The Journal of Physiology. 422: 433-46. PMID 2352187  1
1990 Harrison NL, Lovinger DM, Lambert NA, Teyler TJ, Prager R, Ong J, Kerr DI. The actions of 2-hydroxy-saclofen at presynaptic GABAB receptors in the rat hippocampus. Neuroscience Letters. 119: 272-6. PMID 2177868 DOI: 10.1016/0304-3940(90)90851-Y  1
1990 Ong J, Harrison NL, Hall RG, Barker JL, Johnston GA, Kerr DI. 3-Aminopropanephosphinic acid is a potent agonist at peripheral and central presynaptic GABAB receptors. Brain Research. 526: 138-42. PMID 1964105 DOI: 10.1016/0006-8993(90)90260-I  1
1990 Lambert NA, Harrison NL. Analogs of cyclic AMP decrease gamma-aminobutyric acidA receptor-mediated chloride current in cultured rat hippocampal neurons via an extracellular site. The Journal of Pharmacology and Experimental Therapeutics. 255: 90-4. PMID 1698973  1
1989 Lambert NA, Harrison NL, Kerr DI, Ong J, Prager RH, Teyler TJ. Blockade of the late IPSP in rat CA1 hippocampal neurons by 2-hydroxy-saclofen. Neuroscience Letters. 107: 125-8. PMID 2559366 DOI: 10.1016/0304-3940(89)90803-3  1
1989 Harrison NL, Zatz M. Voltage-dependent calcium channels regulate melatonin output from cultured chick pineal cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 9: 2462-7. PMID 2545839  1
1989 Harrison NL, Lambert NA. Modification of GABAA receptor function by an analog of cyclic AMP. Neuroscience Letters. 105: 137-42. PMID 2484725 DOI: 10.1016/0304-3940(89)90025-6  1
1988 Silva NL, Mariani AP, Harrison NL, Barker JL. 5,7-Dihydroxytryptamine identifies living dopaminergic neurons in mesencephalic cultures. Proceedings of the National Academy of Sciences of the United States of America. 85: 7346-50. PMID 3050994  1
1988 Barker JL, Harrison NL. Outward rectification of inhibitory postsynaptic currents in cultured rat hippocampal neurones. The Journal of Physiology. 403: 41-55. PMID 2908121  1
1988 Harrison NL, Lange GD, Barker JL. Pre- and post-synaptic aspects of GABA-mediated synaptic inhibition in cultured rat hippocampal neurons. Advances in Biochemical Psychopharmacology. 45: 73-85. PMID 2902747  1
1988 Harrison NL, Lange GD, Barker JL. (-)-Baclofen activates presynaptic GABAB receptors on GABAergic inhibitory neurons from embryonic rat hippocampus. Neuroscience Letters. 85: 105-9. PMID 2834671 DOI: 10.1016/0304-3940(88)90437-5  1
1987 Harrison NL, Vicini S, Barker JL. A steroid anesthetic prolongs inhibitory postsynaptic currents in cultured rat hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 7: 604-9. PMID 3819824  1
1987 Harrison NL, Majewska MD, Harrington JW, Barker JL. Structure-activity relationships for steroid interaction with the gamma-aminobutyric acidA receptor complex. The Journal of Pharmacology and Experimental Therapeutics. 241: 346-53. PMID 3033209  1
1987 Barker JL, Harrison NL, Lange GD, Owen DG. Potentiation of gamma-aminobutyric-acid-activated chloride conductance by a steroid anaesthetic in cultured rat spinal neurones. The Journal of Physiology. 386: 485-501. PMID 2445967  1
1987 Barker JL, Dufy B, Harrison NL, Owen DG, MacDonald JF. Signal transduction mechanisms in cultured CNS neurons and clonal pituitary cells. Neuropharmacology. 26: 941-55. PMID 2443868 DOI: 10.1016/0028-3908(87)90073-6  1
1987 Barker JL, Dufy B, Harrington JW, Harrison NL, MacDermott AB, MacDonald JF, Owen DG, Vicini S. Signals transduced by gamma-aminobutyric acid in cultured central nervous system neurons and thyrotropin releasing hormone in clonal pituitary cells. Annals of the New York Academy of Sciences. 494: 1-38. PMID 2440362  1
1987 Harrison NL. Progesterone metabolites enhance GABA activities Trends in Pharmacological Sciences. 8: 334. DOI: 10.1016/0165-6147(87)90139-8  1
1986 Horne AL, Harrison NL, Turner JP, Simmonds MA. Spontaneous paroxysmal activity induced by zero magnesium and bicuculline: suppression by NMDA antagonists and GABA mimetics. European Journal of Pharmacology. 122: 231-8. PMID 3519245 DOI: 10.1016/0014-2999(86)90107-X  1
1986 Barker JL, Harrison NL, Meyers DE, Majewska MD. Steroid modulation of GABAA receptor-coupled Cl- conductance. Clinical Neuropharmacology. 9: 392-4. PMID 2436770  1
1986 Barker JL, Harrison NL, Mariani AP. Benzodiazepine pharmacology of cultured mammalian CNS neurons. Life Sciences. 39: 1959-68. PMID 2431243 DOI: 10.1016/0024-3205(86)90319-X  1
1986 Majewska MD, Harrison NL, Schwartz RD, Barker JL, Paul SM. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science (New York, N.Y.). 232: 1004-7. PMID 2422758  1
1985 Harrison NL, Simmonds MA. Quantitative studies on some antagonists of N-methyl D-aspartate in slices of rat cerebral cortex. British Journal of Pharmacology. 84: 381-91. PMID 2858237  1
1984 Harrison NL, Simmonds MA. Modulation of the GABA receptor complex by a steroid anaesthetic. Brain Research. 323: 287-92. PMID 6098342 DOI: 10.1016/0006-8993(84)90299-3  1
1984 Simmonds MA, Turner JP, Harrison NL. Interactions of steroids with the GABA-A receptor complex Neuropharmacology. 23: 877-878. DOI: 10.1016/0028-3908(84)90290-9  1
1983 Harrison NL, Simmonds MA. Two distinct interactions of barbiturates and chlormethiazole with the GABAA receptor complex in rat cuneate nucleus in vitro. British Journal of Pharmacology. 80: 387-94. PMID 6317133  1
1983 Harrison NL, Simmonds MA. The picrotoxin-like action of a convulsant benzodiazepine, Ro5-3663. European Journal of Pharmacology. 87: 155-8. PMID 6301850 DOI: 10.1016/0014-2999(83)90064-X  1
1982 Harrison NL, Simmonds MA. Sodium valproate enhances responses to GABA receptor activation only at high concentrations. Brain Research. 250: 201-4. PMID 6291721 DOI: 10.1016/0006-8993(82)90971-4  1
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