Ian J. Reynolds - Publications


148 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Aizenman E, Loring RH, Reynolds IJ, Rosenberg PA. The Redox Biology of Excitotoxic Processes: The NMDA Receptor, TOPA Quinone, and the Oxidative Liberation of Intracellular Zinc. Frontiers in Neuroscience. 14: 778. PMID 32792905 DOI: 10.3389/fnins.2020.00778  1
2014 Kalinichev M, Le Poul E, Boléa C, Girard F, Campo B, Fonsi M, Royer-Urios I, Browne SE, Uslaner JM, Davis MJ, Raber J, Duvoisin R, Bate ST, Reynolds IJ, Poli S, et al. Characterization of the novel positive allosteric modulator of the metabotropic glutamate receptor 4 ADX88178 in rodent models of neuropsychiatric disorders. The Journal of Pharmacology and Experimental Therapeutics. 350: 495-505. PMID 24947466 DOI: 10.1124/jpet.114.214437  1
2014 Smith KM, Browne SE, Jayaraman S, Bleickardt CJ, Hodge LM, Lis E, Yao L, Rittle SL, Innocent N, Mullins DE, Boykow G, Reynolds IJ, Hill D, Parker EM, Hodgson RA. Effects of the selective adenosine A2A receptor antagonist, SCH 412348, on the parkinsonian phenotype of MitoPark mice. European Journal of Pharmacology. 728: 31-8. PMID 24486705 DOI: 10.1016/j.ejphar.2014.01.052  1
2012 Le Poul E, Boléa C, Girard F, Poli S, Charvin D, Campo B, Bortoli J, Bessif A, Luo B, Koser AJ, Hodge LM, Smith KM, DiLella AG, Liverton N, Hess F, ... ... Reynolds IJ, et al. A potent and selective metabotropic glutamate receptor 4 positive allosteric modulator improves movement in rodent models of Parkinson's disease. The Journal of Pharmacology and Experimental Therapeutics. 343: 167-77. PMID 22787118 DOI: 10.1124/jpet.112.196063  1
2012 Nikonova EV, Xiong Y, Tanis KQ, Dawson VL, Vogel RL, Finney EM, Stone DJ, Reynolds IJ, Kern JT, Dawson TM. Transcriptional responses to loss or gain of function of the leucine-rich repeat kinase 2 (LRRK2) gene uncover biological processes modulated by LRRK2 activity. Human Molecular Genetics. 21: 163-74. PMID 21972245 DOI: 10.1093/hmg/ddr451  1
2011 Parmentier-Batteur S, Finger EN, Krishnan R, Rajapakse HA, Sanders JM, Kandpal G, Zhu H, Moore KP, Regan CP, Sharma S, Hess JF, Williams TM, Reynolds IJ, Vacca JP, Mark RJ, et al. Attenuation of scratch-induced reactive astrogliosis by novel EphA4 kinase inhibitors. Journal of Neurochemistry. 118: 1016-31. PMID 21736568 DOI: 10.1111/j.1471-4159.2011.07375.x  1
2011 Zhao WQ, Toolan D, Hepler RW, Wolfe AL, Yu Y, Price E, Uebele VN, Schachter JB, Reynolds IJ, Renger JJ, McCampbell A, Ray WJ. High throughput monitoring of amyloid-β(42) assembly into soluble oligomers achieved by sensitive conformation state-dependent immunoassays. Journal of Alzheimer's Disease : Jad. 25: 655-69. PMID 21483096 DOI: 10.3233/JAD-2011-102022  1
2011 Chen HK, Ji ZS, Dodson SE, Miranda RD, Rosenblum CI, Reynolds IJ, Freedman SB, Weisgraber KH, Huang Y, Mahley RW. Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease. The Journal of Biological Chemistry. 286: 5215-21. PMID 21118811 DOI: 10.1074/jbc.M110.151084  1
2010 Lubbers LS, Rowe BA, Hodge LM, Browne SE, Gundersdorf R, Jones P, Hess FJ, Reynolds IJ. PISA, a novel pharmacodynamic assay for assessing poly(ADP-ribose) polymerase (PARP) activity in situ. Journal of Pharmacological and Toxicological Methods. 61: 319-28. PMID 20132901 DOI: 10.1016/j.vascn.2010.01.012  1
2010 Rintoul GL, Reynolds IJ. Mitochondrial trafficking and morphology in neuronal injury. Biochimica Et Biophysica Acta. 1802: 143-50. PMID 19747973 DOI: 10.1016/j.bbadis.2009.09.005  1
2008 Yang ZQ, Barrow JC, Shipe WD, Schlegel KA, Shu Y, Yang FV, Lindsley CW, Rittle KE, Bock MG, Hartman GD, Uebele VN, Nuss CE, Fox SV, Kraus RL, Doran SM, ... ... Reynolds IJ, et al. Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels. Journal of Medicinal Chemistry. 51: 6471-7. PMID 18817368 DOI: 10.1021/jm800830n  1
2008 Dineley KE, Devinney MJ, Zeak JA, Rintoul GL, Reynolds IJ. Glutamate mobilizes [Zn2+] through Ca2+ -dependent reactive oxygen species accumulation. Journal of Neurochemistry. 106: 2184-93. PMID 18624907 DOI: 10.1111/j.1471-4159.2008.05536.x  1
2008 Malin SA, Davis BM, Koerber HR, Reynolds IJ, Albers KM, Molliver DC. Thermal nociception and TRPV1 function are attenuated in mice lacking the nucleotide receptor P2Y2. Pain. 138: 484-96. PMID 18343036 DOI: 10.1016/j.pain.2008.01.026  1
2008 Reynolds IJ. Manifestations of Drug Toxicity on Mitochondria in the Nervous System Drug-Induced Mitochondrial Dysfunction. 251-271. DOI: 10.1002/9780470372531.ch8  1
2007 Gusdon AM, Votyakova TV, Reynolds IJ, Mathews CE. Nuclear and mitochondrial interaction involving mt-Nd2 leads to increased mitochondrial reactive oxygen species production. The Journal of Biological Chemistry. 282: 5171-9. PMID 17189252 DOI: 10.1074/jbc.M609367200  1
2007 Vergun O, Dineley KE, Reynolds IJ. Ion transport and energy metabolism Handbook of Neurochemistry and Molecular Neurobiology: Brain Energetics. Integration of Molecular and Cellular Processes. 429-465. DOI: 10.1007/978-0-387-30411-3_16  1
2006 Chang DT, Reynolds IJ. Mitochondrial trafficking and morphology in healthy and injured neurons. Progress in Neurobiology. 80: 241-68. PMID 17188795 DOI: 10.1016/j.pneurobio.2006.09.003  1
2006 Chang DT, Honick AS, Reynolds IJ. Mitochondrial trafficking to synapses in cultured primary cortical neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 7035-45. PMID 16807333 DOI: 10.1523/JNEUROSCI.1012-06.2006  1
2006 Chang DT, Reynolds IJ. Differences in mitochondrial movement and morphology in young and mature primary cortical neurons in culture. Neuroscience. 141: 727-36. PMID 16797853 DOI: 10.1016/j.neuroscience.2006.01.034  1
2006 Rintoul GL, Bennett VJ, Papaconstandinou NA, Reynolds IJ. Nitric oxide inhibits mitochondrial movement in forebrain neurons associated with disruption of mitochondrial membrane potential. Journal of Neurochemistry. 97: 800-6. PMID 16573650 DOI: 10.1111/j.1471-4159.2006.03788.x  1
2006 Chang DT, Rintoul GL, Pandipati S, Reynolds IJ. Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons. Neurobiology of Disease. 22: 388-400. PMID 16473015 DOI: 10.1016/j.nbd.2005.12.007  1
2005 Malaiyandi LM, Honick AS, Rintoul GL, Wang QJ, Reynolds IJ. Zn2+ inhibits mitochondrial movement in neurons by phosphatidylinositol 3-kinase activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 9507-14. PMID 16221861 DOI: 10.1523/JNEUROSCI.0868-05.2005  1
2005 Vergun O, Reynolds IJ. Distinct characteristics of Ca(2+)-induced depolarization of isolated brain and liver mitochondria. Biochimica Et Biophysica Acta. 1709: 127-37. PMID 16112074 DOI: 10.1016/j.bbabio.2005.07.006  1
2005 Dineley KE, Richards LL, Votyakova TV, Reynolds IJ. Zinc causes loss of membrane potential and elevates reactive oxygen species in rat brain mitochondria. Mitochondrion. 5: 55-65. PMID 16060292 DOI: 10.1016/j.mito.2004.11.001  1
2005 Kress GJ, Reynolds IJ. Dopaminergic neurotoxins require excitotoxic stimulation in organotypic cultures. Neurobiology of Disease. 20: 639-45. PMID 15996475 DOI: 10.1016/j.nbd.2005.04.019  1
2005 Malaiyandi LM, Vergun O, Dineley KE, Reynolds IJ. Direct visualization of mitochondrial zinc accumulation reveals uniporter-dependent and -independent transport mechanisms. Journal of Neurochemistry. 93: 1242-50. PMID 15934944 DOI: 10.1111/j.1471-4159.2005.03116.x  1
2005 Votyakova TV, Reynolds IJ. Ca2+-induced permeabilization promotes free radical release from rat brain mitochondria with partially inhibited complex I. Journal of Neurochemistry. 93: 526-37. PMID 15836612 DOI: 10.1111/j.1471-4159.2005.03042.x  1
2005 Wilson MS, Chen X, Ma X, Ren D, Wagner AK, Reynolds IJ, Dixon CE. Synaptosomal dopamine uptake in rat striatum following controlled cortical impact. Journal of Neuroscience Research. 80: 85-91. PMID 15704194 DOI: 10.1002/jnr.20419  1
2005 Devinney MJ, Reynolds IJ, Dineley KE. Simultaneous detection of intracellular free calcium and zinc using fura-2FF and FluoZin-3. Cell Calcium. 37: 225-32. PMID 15670869 DOI: 10.1016/j.ceca.2004.10.003  1
2004 Votyakova TV, Reynolds IJ. Detection of hydrogen peroxide with Amplex Red: interference by NADH and reduced glutathione auto-oxidation. Archives of Biochemistry and Biophysics. 431: 138-44. PMID 15464736 DOI: 10.1016/j.abb.2004.07.025  1
2004 Reynolds IJ, Rintoul GL. Mitochondrial stop and go: signals that regulate organelle movement. Science's Stke : Signal Transduction Knowledge Environment. 2004: PE46. PMID 15383673 DOI: 10.1126/stke.2512004pe46  1
2004 Reynolds IJ, Malaiyandi LM, Coash M, Rintoul GL. Mitochondrial trafficking in neurons: a key variable in neurodegeneration? Journal of Bioenergetics and Biomembranes. 36: 283-6. PMID 15377858 DOI: 10.1023/B:JOBB.0000041754.78313.c2  1
2004 Vergun O, Reynolds IJ. Fluctuations in mitochondrial membrane potential in single isolated brain mitochondria: modulation by adenine nucleotides and Ca2+. Biophysical Journal. 87: 3585-93. PMID 15315954 DOI: 10.1529/biophysj.104.042671  1
2004 Reynolds IJ. Fluorescence detection of redox-sensitive metals in neuronal culture: focus on iron and zinc. Annals of the New York Academy of Sciences. 1012: 27-36. PMID 15105253 DOI: 10.1196/annals.1306.003  1
2004 Venneti S, Lopresti BJ, Wang G, Bissel SJ, Mathis CA, Meltzer CC, Boada F, Capuano S, Kress GJ, Davis DK, Ruszkiewicz J, Reynolds IJ, Murphey-Corb M, Trichel AM, Wisniewski SR, et al. PET imaging of brain macrophages using the peripheral benzodiazepine receptor in a macaque model of neuroAIDS. The Journal of Clinical Investigation. 113: 981-9. PMID 15057304 DOI: 10.1172/JCI20227  1
2004 Glading A, Bodnar RJ, Reynolds IJ, Shiraha H, Satish L, Potter DA, Blair HC, Wells A. Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation. Molecular and Cellular Biology. 24: 2499-512. PMID 14993287 DOI: 10.1128/MCB.24.13.6116.2004  1
2004 Malaiyandi LM, Dineley KE, Reynolds IJ. Divergent consequences arise from metallothionein overexpression in astrocytes: zinc buffering and oxidant-induced zinc release. Glia. 45: 346-53. PMID 14966866 DOI: 10.1002/glia.10332  1
2004 Kang HJ, Choi YS, Hong SB, Kim KW, Woo RS, Won SJ, Kim EJ, Jeon HK, Jo SY, Kim TK, Bachoo R, Reynolds IJ, Gwag BJ, Lee HW. Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 1280-7. PMID 14960598 DOI: 10.1523/JNEUROSCI.4082-03.2004  1
2003 Vergun O, Votyakova TV, Reynolds IJ. Spontaneous changes in mitochondrial membrane potential in single isolated brain mitochondria. Biophysical Journal. 85: 3358-66. PMID 14581237 DOI: 10.1016/S0006-3495(03)74755-9  1
2003 Vergun O, Han YY, Reynolds IJ. Glucose deprivation produces a prolonged increase in sensitivity to glutamate in cultured rat cortical neurons. Experimental Neurology. 183: 682-94. PMID 14552910 DOI: 10.1016/S0014-4886(03)00243-7  1
2003 Rintoul GL, Filiano AJ, Brocard JB, Kress GJ, Reynolds IJ. Glutamate decreases mitochondrial size and movement in primary forebrain neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 7881-8. PMID 12944518  1
2003 Brocard JB, Rintoul GL, Reynolds IJ. New perspectives on mitochondrial morphology in cell function. Biology of the Cell / Under the Auspices of the European Cell Biology Organization. 95: 239-42. PMID 12941521 DOI: 10.1016/S0248-4900(03)00062-5  1
2003 Dineley KE, Votyakova TV, Reynolds IJ. Zinc inhibition of cellular energy production: implications for mitochondria and neurodegeneration. Journal of Neurochemistry. 85: 563-70. PMID 12694382  1
2002 Dineley KE, Brocard JB, Reynolds IJ. Elevated intracellular zinc and altered proton homeostasis in forebrain neurons. Neuroscience. 114: 439-49. PMID 12204213 DOI: 10.1016/S0306-4522(02)00294-4  1
2002 Dineley KE, Malaiyandi LM, Reynolds IJ. A reevaluation of neuronal zinc measurements: artifacts associated with high intracellular dye concentration. Molecular Pharmacology. 62: 618-27. PMID 12181438 DOI: 10.1124/mol.62.3.618  1
2002 Tang ZL, Wasserloos KJ, Liu X, Stitt MS, Reynolds IJ, Pitt BR, St Croix CM. Nitric oxide decreases the sensitivity of pulmonary endothelial cells to LPS-induced apoptosis in a zinc-dependent fashion. Molecular and Cellular Biochemistry. 234: 211-7. PMID 12162436 DOI: 10.1023/A:1015930927407  1
2002 Kress GJ, Dineley KE, Reynolds IJ. The relationship between intracellular free iron and cell injury in cultured neurons, astrocytes, and oligodendrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 5848-55. PMID 12122047  1
2002 St Croix CM, Wasserloos KJ, Dineley KE, Reynolds IJ, Levitan ES, Pitt BR. Nitric oxide-induced changes in intracellular zinc homeostasis are mediated by metallothionein/thionein. American Journal of Physiology. Lung Cellular and Molecular Physiology. 282: L185-92. PMID 11792622 DOI: 10.1152/ajplung.00267.2001  1
2001 Reynolds IJ. [3H](+)MK801 radioligand binding assay at the N-methyl-D-aspartate receptor. Current Protocols in Pharmacology / Editorial Board, S.J. Enna (Editor-in-Chief) ... [Et Al.]. Unit 1.20. PMID 22293962 DOI: 10.1002/0471141755.ph0120s11  1
2001 Reynolds IJ. Measurement of cation movement in primary cultures using fluorescent dyes. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit7.11. PMID 18428522 DOI: 10.1002/0471142301.ns0711s04  1
2001 Votyakova TV, Reynolds IJ. DeltaPsi(m)-Dependent and -independent production of reactive oxygen species by rat brain mitochondria. Journal of Neurochemistry. 79: 266-77. PMID 11677254 DOI: 10.1046/j.1471-4159.2001.00548.x  1
2001 Birder LA, Kanai AJ, de Groat WC, Kiss S, Nealen ML, Burke NE, Dineley KE, Watkins S, Reynolds IJ, Caterina MJ. Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 98: 13396-401. PMID 11606761 DOI: 10.1073/pnas.231243698  1
2001 Buckman JF, Reynolds IJ. Spontaneous changes in mitochondrial membrane potential in cultured neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 5054-65. PMID 11438581  1
2001 Brocard JB, Tassetto M, Reynolds IJ. Quantitative evaluation of mitochondrial calcium content in rat cortical neurones following a glutamate stimulus. The Journal of Physiology. 531: 793-805. PMID 11251059 DOI: 10.1111/j.1469-7793.2001.0793h.x  1
2001 Buckman JF, Hernández H, Kress GJ, Votyakova TV, Pal S, Reynolds IJ. MitoTracker labeling in primary neuronal and astrocytic cultures: influence of mitochondrial membrane potential and oxidants. Journal of Neuroscience Methods. 104: 165-76. PMID 11164242 DOI: 10.1016/S0165-0270(00)00340-X  1
2000 Scanlon JM, Brocard JB, Stout AK, Reynolds IJ. Pharmacological investigation of mitochondrial ca(2+) transport in central neurons: studies with CGP-37157, an inhibitor of the mitochondrial Na(+)-Ca(2+) exchanger. Cell Calcium. 28: 317-27. PMID 11115371 DOI: 10.1054/ceca.2000.0171  1
2000 Aizenman E, Stout AK, Hartnett KA, Dineley KE, McLaughlin B, Reynolds IJ. Induction of neuronal apoptosis by thiol oxidation: putative role of intracellular zinc release. Journal of Neurochemistry. 75: 1878-88. PMID 11032877 DOI: 10.1046/j.1471-4159.2000.0751878.x  1
2000 Dineley KE, Scanlon JM, Kress GJ, Stout AK, Reynolds IJ. Astrocytes are more resistant than neurons to the cytotoxic effects of increased [Zn(2+)](i). Neurobiology of Disease. 7: 310-20. PMID 10964603 DOI: 10.1006/nbdi.2000.0303  1
2000 Hoyt KR, McLaughlin BA, Higgins DS, Reynolds IJ. Inhibition of glutamate-induced mitochondrial depolarization by tamoxifen in cultured neurons. The Journal of Pharmacology and Experimental Therapeutics. 293: 480-6. PMID 10773018  1
2000 Cheng C, Reynolds IJ. Subcellular localization of glutamate-stimulated intracellular magnesium concentration changes in cultured rat forebrain neurons using confocal microscopy. Neuroscience. 95: 973-9. PMID 10682704 DOI: 10.1016/S0306-4522(99)00471-6  1
1999 Reynolds IJ. Mitochondrial membrane potential and the permeability transition in excitotoxicity. Annals of the New York Academy of Sciences. 893: 33-41. PMID 10672228  1
1999 Cheng C, Fass DM, Reynolds IJ. Emergence of excitotoxicity in cultured forebrain neurons coincides with larger glutamate-stimulated [Ca(2+)](i) increases and NMDA receptor mRNA levels. Brain Research. 849: 97-108. PMID 10592291 DOI: 10.1016/S0006-8993(99)01995-2  1
1999 Tao B, Huang TL, Sharma TA, Reynolds IJ, Donkor IO. Novel bisbenzamidines and bisbenzimidazolines as noncompetitive NMDA receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 9: 1299-304. PMID 10340618 DOI: 10.1016/S0960-894X(99)00184-5  1
1999 Reynolds IJ, Sharma TA. The use of ligand binding in assays of NMDA receptor function. Methods in Molecular Biology (Clifton, N.J.). 128: 93-102. PMID 10320975 DOI: 10.1385/1-59259-683-5:93  1
1999 Sharma TA, Reynolds IJ. Characterization of the effects of polyamines on [125I]MK-801 binding to recombinant N-methyl-D-aspartate receptors. The Journal of Pharmacology and Experimental Therapeutics. 289: 1041-7. PMID 10215685  1
1999 Stout AK, Reynolds IJ. High-affinity calcium indicators underestimate increases in intracellular calcium concentrations associated with excitotoxic glutamate stimulations. Neuroscience. 89: 91-100. PMID 10051219 DOI: 10.1016/S0306-4522(98)00441-2  1
1998 Stout AK, Raphael HM, Kanterewicz BI, Klann E, Reynolds IJ. Glutamate-induced neuron death requires mitochondrial calcium uptake. Nature Neuroscience. 1: 366-73. PMID 10196525 DOI: 10.1038/1577  1
1998 Sharma TA, Carr AJ, Davis RS, Reynolds IJ, Hamilton AD. Aromatic analogs of arcaine inhibit MK-801 binding to the NMDA receptor. Bioorganic & Medicinal Chemistry Letters. 8: 3459-64. PMID 9934452 DOI: 10.1016/S0960-894X(98)00631-3  1
1998 Reynolds IJ. Intracellular calcium and magnesium: critical determinants of excitotoxicity? Progress in Brain Research. 116: 225-43. PMID 9932380  1
1998 Carlier PR, Lo MM, Lo PC, Richelson E, Tatsumi M, Reynolds IJ, Sharma TA. Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the gamma-amino alcohol functional group. Bioorganic & Medicinal Chemistry Letters. 8: 487-92. PMID 9871604 DOI: 10.1016/S0960-894X(98)00062-6  1
1998 Cheng C, Reynolds IJ. Calcium-sensitive fluorescent dyes can report increases in intracellular free zinc concentration in cultured forebrain neurons. Journal of Neurochemistry. 71: 2401-10. PMID 9832138  1
1998 Scanlon JM, Reynolds IJ. Effects of oxidants and glutamate receptor activation on mitochondrial membrane potential in rat forebrain neurons. Journal of Neurochemistry. 71: 2392-400. PMID 9832137  1
1998 Sharma TA, Reynolds IJ. Complex polyamine effects on [3H]MDL 105,519 binding to the NMDA receptor glycine site. Neurochemistry International. 33: 155-9. PMID 9761459 DOI: 10.1016/S0197-0186(98)00015-1  1
1998 Hoyt KR, Reynolds IJ. Alkalinization prolongs recovery from glutamate-induced increases in intracellular Ca2+ concentration by enhancing Ca2+ efflux through the mitochondrial Na+/Ca2+ exchanger in cultured rat forebrain neurons. Journal of Neurochemistry. 71: 1051-8. PMID 9721729  1
1998 Hoyt KR, Stout AK, Cardman JM, Reynolds IJ. The role of intracellular Na+ and mitochondria in buffering of kainate-induced intracellular free Ca2+ changes in rat forebrain neurones. The Journal of Physiology. 509: 103-16. PMID 9547385 DOI: 10.1111/j.1469-7793.1998.103bo.x  1
1998 Hoyt KR, Arden SR, Aizenman E, Reynolds IJ. Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+ concentration increases in cultured rat forebrain neurons. Molecular Pharmacology. 53: 742-9. PMID 9547366  1
1997 Hoyt KR, Sharma TA, Reynolds IJ. Trifluoperazine and dibucaine-induced inhibition of glutamate-induced mitochondrial depolarization in rat cultured forebrain neurones. British Journal of Pharmacology. 122: 803-8. PMID 9384493 DOI: 10.1038/sj.bjp.0701442  1
1997 Bertz RJ, Kroboth PD, Kroboth FJ, Reynolds IJ, Salek F, Wright CE, Smith RB. Alprazolam in young and elderly men: sensitivity and tolerance to psychomotor, sedative and memory effects. The Journal of Pharmacology and Experimental Therapeutics. 281: 1317-29. PMID 9190868  1
1997 Scanlon JM, Aizenman E, Reynolds IJ. Effects of pyrroloquinoline quinone on glutamate-induced production of reactive oxygen species in neurons. European Journal of Pharmacology. 326: 67-74. PMID 9178657 DOI: 10.1016/S0014-2999(97)00137-4  1
1997 Hartnett KA, Stout AK, Rajdev S, Rosenberg PA, Reynolds IJ, Aizenman E. NMDA receptor-mediated neurotoxicity: a paradoxical requirement for extracellular Mg2+ in Na+/Ca2+-free solutions in rat cortical neurons in vitro. Journal of Neurochemistry. 68: 1836-45. PMID 9109508  1
1997 Hoyt KR, Reynolds IJ, Hastings TG. Mechanisms of dopamine-induced cell death in cultured rat forebrain neurons: interactions with and differences from glutamate-induced cell death. Experimental Neurology. 143: 269-81. PMID 9056389 DOI: 10.1006/exnr.1996.6374  1
1997 Hoyt KR, Gallagher AJ, Hastings TG, Reynolds IJ. Characterization of hydrogen peroxide toxicity in cultured rat forebrain neurons. Neurochemical Research. 22: 333-40. PMID 9051670 DOI: 10.1023/A:1022403224901  1
1997 White RJ, Reynolds IJ. Mitochondria accumulate Ca2+ following intense glutamate stimulation of cultured rat forebrain neurones. The Journal of Physiology. 498: 31-47. PMID 9023766  1
1996 Hoyt KR, Reynolds IJ. Localization of D1 dopamine receptors on live cultured striatal neurons by quantitative fluorescence microscopy. Brain Research. 731: 21-30. PMID 8883850 DOI: 10.1016/S0006-8993(96)00436-2  1
1996 White RJ, Reynolds IJ. Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 5688-97. PMID 8795624  1
1996 Stout AK, Li-Smerin Y, Johnson JW, Reynolds IJ. Mechanisms of glutamate-stimulated Mg2+ influx and subsequent Mg2+ efflux in rat forebrain neurones in culture. The Journal of Physiology. 492: 641-57. PMID 8734978  1
1995 Bertz RJ, Reynolds IJ, Kroboth PD. Effect of neuroactive steroids on [3H]flumazenil binding to the GABAA receptor complex in vitro. Neuropharmacology. 34: 1169-75. PMID 8532187 DOI: 10.1016/0028-3908(95)00072-E  1
1995 Reynolds IJ, Rothermund KD. Characterization of the effects of polyamines on the modulation of the N-methyl-D-aspartate receptor by glycine. Neuropharmacology. 34: 1147-57. PMID 8532185 DOI: 10.1016/0028-3908(95)00086-L  1
1995 White RJ, Reynolds IJ. Mitochondria and Na+/Ca2+ exchange buffer glutamate-induced calcium loads in cultured cortical neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 1318-28. PMID 7869100  1
1995 Reynolds IJ, Hastings TG. Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 3318-27. PMID 7751912  1
1995 McAuley JW, Reynolds IJ, Kroboth FJ, Smith RB, Kroboth PD. Orally administered progesterone enhances sensitivity to triazolam in postmenopausal women. Journal of Clinical Psychopharmacology. 15: 3-11. PMID 7714225 DOI: 10.1097/00004714-199502000-00002  1
1995 Hoyt KR, Rajdev S, Fattman CL, Reynolds IJ. Cyclothiazide modulates AMPA receptor-mediated increases in intracellular free Ca2+ and Mg2+ in cultured neurons from rat brain. Journal of Neurochemistry. 64: 2049-56. PMID 7536804  1
1995 Rajdev S, Reynolds IJ. Calcium influx but not pH or ATP level mediates glutamate-induced changes in intracellular magnesium in cortical neurons. Journal of Neurophysiology. 74: 942-9. PMID 7500163  1
1994 Weng W, Reynolds IJ, Jani JP, Blaskovich M, Sebti SM, Davies P, Pitt BR. Desensitization of 5HT2 receptors by protein kinase C activation in distal pulmonary vascular smooth muscle cells in culture. Microcirculation (New York, N.Y. : 1994). 1: 129-35. PMID 8790584 DOI: 10.3109/10739689409148268  1
1994 Pitt BR, Weng W, Steve AR, Blakely RD, Reynolds I, Davies P. Serotonin increases DNA synthesis in rat proximal and distal pulmonary vascular smooth muscle cells in culture. The American Journal of Physiology. 266: L178-86. PMID 8141313 DOI: 10.1152/ajplung.1994.266.2.L178  0.36
1994 Reynolds IJ. [3H]CGP 39653 binding to the agonist site of the N-methyl-D-aspartate receptor is modulated by Mg2+ and polyamines independently of the arcaine-sensitive polyamine site. Journal of Neurochemistry. 62: 54-62. PMID 7903355  1
1994 Rajdev S, Reynolds IJ. Glutamate-induced intracellular calcium changes and neurotoxicity in cortical neurons in vitro: effect of chemical ischemia. Neuroscience. 62: 667-79. PMID 7870298 DOI: 10.1016/0306-4522(94)90468-5  1
1993 McAuley JW, Kroboth PD, Stiff DD, Reynolds IJ. Modulation of [3H]flunitrazepam binding by natural and synthetic progestational agents. Pharmacology, Biochemistry, and Behavior. 45: 77-83. PMID 8516376 DOI: 10.1016/0091-3057(93)90089-C  1
1993 Rajdev S, Reynolds IJ. Effects of pH on the actions of dizocilpine at the N-methyl-D-aspartate receptor complex. British Journal of Pharmacology. 109: 107-12. PMID 8495234  1
1993 Reynolds IJ, Zeleski DM, Rothermund KD, Hartnett KA, Tidwell R, Aizenman E. Studies on the effects of several pentamidine analogues on the NMDA receptor. European Journal of Pharmacology. 244: 175-9. PMID 8432312 DOI: 10.1016/0922-4106(93)90023-3  1
1993 Brocard JB, Rajdev S, Reynolds IJ. Glutamate-induced increases in intracellular free Mg2+ in cultured cortical neurons. Neuron. 11: 751-7. PMID 8104432 DOI: 10.1016/0896-6273(93)90084-5  1
1993 Rajdev S, Reynolds IJ. Calcium green-5N, a novel fluorescent probe for monitoring high intracellular free Ca2+ concentrations associated with glutamate excitotoxicity in cultured rat brain neurons. Neuroscience Letters. 162: 149-52. PMID 7907171 DOI: 10.1016/0304-3940(93)90582-6  1
1993 Reynolds IJ, Rothermund KD, Rajdev S. Interaction of rigid polyamine analogues with the NMDA receptor complex from rat brain Bioorganic and Medicinal Chemistry Letters. 3: 85-90. DOI: 10.1016/S0960-894X(00)80097-9  1
1992 Aizenman E, Reynolds IJ. Modulation of NMDA excitotoxicity by redox reagents. Annals of the New York Academy of Sciences. 648: 125-31. PMID 1637042  1
1992 Reynolds IJ. 1,5-(Diethylamino)piperidine, a novel spermidine analogue that more specifically activates the N-methyl-D-aspartate receptor-associated polyamine site. Molecular Pharmacology. 41: 989-92. PMID 1535417  1
1992 Rajdev S, Reynolds IJ. Effects of monovalent and divalent cations on 3-(+)[125I]iododizocilpine binding to the N-methyl-D-aspartate receptor of rat brain membranes. Journal of Neurochemistry. 58: 1469-76. PMID 1532196  1
1992 Reynolds IJ, Aizenman E. Pentamidine is an N-methyl-D-aspartate receptor antagonist and is neuroprotective in vitro. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 970-5. PMID 1532027  1
1992 Hoyt KR, Tang LH, Aizenman E, Reynolds IJ. Nitric oxide modulates NMDA-induced increases in intracellular Ca2+ in cultured rat forebrain neurons. Brain Research. 592: 310-6. PMID 1450920 DOI: 10.1016/0006-8993(92)91690-G  1
1992 Reynolds IJ. Interactions between zinc and spermidine on the N-methyl-D-aspartate receptor complex: clues to the mechanism of action of 1,10-bis(guanidino)decane and pentamidine. The Journal of Pharmacology and Experimental Therapeutics. 263: 632-8. PMID 1432693  1
1992 Mistry JS, Jani JP, Morris G, Mujumdar RB, Reynolds IJ, Sebti SM, Lazo JS. Synthesis and evaluation of fluoromycin: a novel fluorescence-labeled derivative of talisomycin S10b. Cancer Research. 52: 709-18. PMID 1370650  1
1992 Reynolds IJ, Rothermund K, Rajdev S, Fauq AH, Kozikowski AP. [125I]thienylphencyclidine, a novel ligand for the NMDA receptor. European Journal of Pharmacology. 226: 53-8. PMID 1356810 DOI: 10.1016/0922-4106(92)90082-7  1
1992 Chen C, Kozikowski AP, Wood PL, Reynolds IJ, Ball RG, Pang YP. Synthesis and biological activity of 8a-phenyldecahydroquinolines as probes of PCP's binding conformation. A new PCP-like compound with increased in vivo potency. Journal of Medicinal Chemistry. 35: 1634-8. PMID 1315871  1
1991 Gilbert KR, Aizenman E, Reynolds IJ. Oxidized glutathione modulates N-methyl-D-aspartate- and depolarization-induced increases in intracellular Ca2+ in cultured rat forebrain neurons. Neuroscience Letters. 133: 11-4. PMID 1838798 DOI: 10.1016/0304-3940(91)90045-U  1
1991 Reynolds IJ, Bear MF. Effects of age and visual experience on [3H] MK801 binding to NMDA receptors in the kitten visual cortex. Experimental Brain Research. 85: 611-5. PMID 1833218 DOI: 10.1007/BF00231745  1
1991 Aizenman E, Tang LH, Reynolds IJ. Effects of nicotinic agonists on the NMDA receptor. Brain Research. 551: 355-7. PMID 1833030 DOI: 10.1016/0006-8993(91)90958-X  1
1991 Reynolds IJ. The spider toxin, argiotoxin636, binds to a Mg2+ site on the N-methyl-D-aspartate receptor complex. British Journal of Pharmacology. 103: 1373-6. PMID 1832066  1
1991 Reynolds IJ, Palmer AM. Regional variations in [3H]MK801 binding to rat brain N-methyl-D-aspartate receptors. Journal of Neurochemistry. 56: 1731-40. PMID 1826521  1
1991 Reynolds IJ, Baron BM, Edwards ML. 1,10-bis(guanidino)decane inhibits N-methyl-D-aspartate responses in vitro and in vivo. The Journal of Pharmacology and Experimental Therapeutics. 259: 626-32. PMID 1658306  1
1990 Kozikowski AP, Tückmantel W, Reynolds IJ, Wroblewski JT. Synthesis and bioactivity of a new class of rigid glutamate analogues. Modulators of the N-methyl-D-aspartate receptor. Journal of Medicinal Chemistry. 33: 1561-71. PMID 2160533  1
1990 Reynolds IJ. Arcaine is a competitive antagonist of the polyamine site on the NMDA receptor. European Journal of Pharmacology. 177: 215-6. PMID 2155812 DOI: 10.1016/0014-2999(90)90274-A  1
1990 Reynolds IJ, Rush EA. Role of lipid solubility in the interaction of drugs with the N-methyl-D-aspartate receptor. Synapse (New York, N.Y.). 5: 71-6. PMID 2154058 DOI: 10.1002/syn.890050107  1
1990 Reynolds IJ, Rush EA, Aizenman E. Reduction of NMDA receptors with dithiothreitol increases [3H]-MK-801 binding and NMDA-induced Ca2+ fluxes. British Journal of Pharmacology. 101: 178-82. PMID 2149291  1
1990 Aizenman E, Hartnett KA, Reynolds IJ. Oxygen free radicals regulate NMDA receptor function via a redox modulatory site. Neuron. 5: 841-6. PMID 2148489 DOI: 10.1016/0896-6273(90)90343-E  1
1990 Reynolds IJ, Miller RJ. Allosteric modulation of N-methyl-D-aspartate receptors. Advances in Pharmacology (San Diego, Calif.). 21: 101-26. PMID 2148268  1
1990 Reynolds IJ. Arcaine uncovers dual interactions of polyamines with the N-methyl-D-aspartate receptor. The Journal of Pharmacology and Experimental Therapeutics. 255: 1001-7. PMID 2148185  1
1990 Reynolds IJ. Modulation of NMDA receptor responsiveness by neurotransmitters, drugs and chemical modification. Life Sciences. 47: 1785-92. PMID 1979653 DOI: 10.1016/0024-3205(90)90280-5  1
1990 Lehmann J, Randle JCR, Reynolds IJ. Excitatory amino acid receptors: NMDA modulatory sites, kainate cloned and a new role in AIDS Trends in Pharmacological Sciences. 11: 1-3. DOI: 10.1016/0165-6147(90)90031-3  1
1989 Reynolds IJ, Miller RJ. Muscarinic agonists cause calcium influx and calcium mobilization in forebrain neurons in vitro. Journal of Neurochemistry. 53: 226-33. PMID 2723657  1
1989 Reynolds IJ, Miller RJ. Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines. Molecular Pharmacology. 36: 758-65. PMID 2555674  1
1989 Baron BM, Dudley MW, McCarty DR, Miller FP, Reynolds IJ, Schmidt CJ. Guanine nucleotides are competitive inhibitors of N-methyl-D-aspartate at its receptor site both in vitro and in vivo. The Journal of Pharmacology and Experimental Therapeutics. 250: 162-9. PMID 2545857  1
1989 Wagner JA, Weisman HF, Snowman AM, Reynolds IJ, Weisfeldt ML, Snyder SH. Alterations in calcium antagonist receptors and sodium-calcium exchange in cardiomyopathic hamster tissues. Circulation Research. 65: 205-14. PMID 2544319 DOI: 10.1161/01.RES.65.1.205  1
1989 Reynolds IJ, Harris KM, Miller RJ. NMDA receptor antagonists that bind to the strychnine-insensitive glycine site and inhibit NMDA-induced Ca2+ fluxes and [3H]GABA release. European Journal of Pharmacology. 172: 9-17. PMID 2541002 DOI: 10.1016/0922-4106(89)90040-0  1
1988 Reynolds IJ, Miller RJ. Tricyclic antidepressants block N-methyl-D-aspartate receptors: similarities to the action of zinc. British Journal of Pharmacology. 95: 95-102. PMID 2905906  1
1988 Reynolds IJ, Snyder SH. Calcium antagonist receptors. Ion Channels. 1: 213-49. PMID 2856492 DOI: 10.1007/978-1-4615-7302-9_6  1
1988 Reynolds IJ, Miller RJ. [3H]MK801 binding to the N-methyl-D-aspartate receptor reveals drug interactions with the zinc and magnesium binding sites. The Journal of Pharmacology and Experimental Therapeutics. 247: 1025-31. PMID 2849655  1
1988 Reynolds IJ, Miller RJ. [3H]MK801 binding to the NMDA receptor/ionophore complex is regulated by divalent cations: evidence for multiple regulatory sites. European Journal of Pharmacology. 151: 103-12. PMID 2843387 DOI: 10.1016/0014-2999(88)90697-8  1
1988 Reynolds IJ, Miller RJ. Multiple sites for the regulation of the N-methyl-D-aspartate receptor. Molecular Pharmacology. 33: 581-4. PMID 2837634  1
1988 Wagner JA, Guggino SE, Reynolds IJ, Snowman AM, Biswas A, Olivera BM, Snyder SH. Calcium antagonist receptors. Clinical and physiological relevance. Annals of the New York Academy of Sciences. 522: 116-33. PMID 2454047 DOI: 10.1111/J.1749-6632.1988.TB33349.X  1
1987 Reynolds IJ, Murphy SN, Miller RJ. 3H-labeled MK-801 binding to the excitatory amino acid receptor complex from rat brain is enhanced by glycine. Proceedings of the National Academy of Sciences of the United States of America. 84: 7744-8. PMID 2823273  1
1987 Wagner JA, Reynolds IJ, Snyder SH. Physiological and pharmacological correlates of calcium antagonist receptors. Journal of Cardiovascular Pharmacology. 10: S1-9. PMID 2455102  1
1986 Reynolds IJ, Snowman AM, Snyder SH. (-)-[3H] desmethoxyverapamil labels multiple calcium channel modulator receptors in brain and skeletal muscle membranes: differentiation by temperature and dihydropyridines. The Journal of Pharmacology and Experimental Therapeutics. 237: 731-8. PMID 3012067  1
1986 Wagner JA, Reynolds IJ, Weisman HF, Dudeck P, Weisfeldt ML, Snyder SH. Calcium antagonist receptors in cardiomyopathic hamster: selective increases in heart, muscle, brain. Science (New York, N.Y.). 232: 515-8. PMID 3008330 DOI: 10.1126/SCIENCE.3008330  1
1986 Reynolds IJ, Wagner JA, Snyder SH, Thayer SA, Olivera BM, Miller RJ. Brain voltage-sensitive calcium channel subtypes differentiated by omega-conotoxin fraction GVIA. Proceedings of the National Academy of Sciences of the United States of America. 83: 8804-7. PMID 2430302 DOI: 10.1073/pnas.83.22.8804  1
1985 Snyder SH, Reynolds IJ. Calcium-antagonist drugs. Receptor interactions that clarify therapeutic effects. The New England Journal of Medicine. 313: 995-1002. PMID 2413355 DOI: 10.1056/NEJM198510173131606  1
1984 Reynolds IJ, Gould RJ, Snyder SH. Loperamide: blockade of calcium channels as a mechanism for antidiarrheal effects. The Journal of Pharmacology and Experimental Therapeutics. 231: 628-32. PMID 6502516  1
1984 Gould RJ, Murphy KM, Reynolds IJ, Snyder SH. Calcium channel blockade: possible explanation for thioridazine's peripheral side effects. The American Journal of Psychiatry. 141: 352-7. PMID 6322598 DOI: 10.1176/AJP.141.3.352  1
1983 Reynolds IJ, Gould RJ, Snyder SH. [3H]Verapamil binding sites in brain and skeletal muscle: regulation by calcium. European Journal of Pharmacology. 95: 319-21. PMID 6317417 DOI: 10.1016/0014-2999(83)90655-6  1
1983 Gould RJ, Murphy KM, Reynolds IJ, Snyder SH. Antischizophrenic drugs of the diphenylbutylpiperidine type act as calcium channel antagonists. Proceedings of the National Academy of Sciences of the United States of America. 80: 5122-5. PMID 6136040 DOI: 10.1073/PNAS.80.16.5122  1
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