| Year |
Citation |
Score |
| 2024 |
Belur NR, Bustos BI, Lubbe SJ, Mazzulli JR. Nuclear aggregates of NONO/SFPQ and A-to-I-edited RNA in Parkinson's disease and dementia with Lewy bodies. Neuron. PMID 38761794 DOI: 10.1016/j.neuron.2024.05.003 |
0.483 |
|
| 2024 |
Zalon AJ, Quiriconi DJ, Pitcairn C, Mazzulli JR. α-Synuclein: Multiple pathogenic roles in trafficking and proteostasis pathways in Parkinson's disease. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 10738584241232963. PMID 38420922 DOI: 10.1177/10738584241232963 |
0.503 |
|
| 2023 |
Fagen SJ, Burgess JD, Lim MJ, Amerna D, Kaya ZB, Faroqi AH, Perisetla P, DeMeo NN, Stojkovska I, Quiriconi DJ, Mazzulli JR, Delenclos M, Boschen SL, McLean PJ. Honokiol decreases alpha-synuclein mRNA levels and reveals novel targets for modulating alpha-synuclein expression. Frontiers in Aging Neuroscience. 15: 1179086. PMID 37637959 DOI: 10.3389/fnagi.2023.1179086 |
0.465 |
|
| 2023 |
Drobny A, Boros FA, Balta D, Prieto Huarcaya S, Caylioglu D, Qazi N, Vandrey J, Schneider Y, Dobert JP, Pitcairn C, Mazzulli JR, Zunke F. Reciprocal effects of alpha-synuclein aggregation and lysosomal homeostasis in synucleinopathy models. Translational Neurodegeneration. 12: 31. PMID 37312133 DOI: 10.1186/s40035-023-00363-z |
0.467 |
|
| 2023 |
Pitcairn C, Murata N, Zalon A, Stojkovska I, Mazzulli JR. Impaired autophagic-lysosomal fusion in Parkinson's patient midbrain neurons occurs through loss of ykt6 and is rescued by farnesyltransferase inhibition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 36788031 DOI: 10.1523/JNEUROSCI.0610-22.2023 |
0.461 |
|
| 2022 |
Prieto Huarcaya S, Drobny A, Marques ARA, Di Spiezio A, Dobert JP, Balta D, Werner C, Rizo T, Gallwitz L, Bub S, Stojkovska I, Belur NR, Fogh J, Mazzulli JR, Xiang W, et al. Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models. Autophagy. PMID 35287553 DOI: 10.1080/15548627.2022.2045534 |
0.485 |
|
| 2022 |
Francelle L, Mazzulli JR. Neuroinflammation in Gaucher disease, neuronal ceroid lipofuscinosis, and commonalities with Parkinson's disease. Brain Research. 1780: 147798. PMID 35063468 DOI: 10.1016/j.brainres.2022.147798 |
0.442 |
|
| 2021 |
Fredriksen K, Aivazidis S, Sharma K, Burbidge KJ, Pitcairn C, Zunke F, Gelyana E, Mazzulli JR. Pathological α-syn aggregation is mediated by glycosphingolipid chain length and the physiological state of α-syn in vivo. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34893541 DOI: 10.1073/pnas.2108489118 |
0.395 |
|
| 2021 |
Stojkovska I, Wani WY, Zunke F, Belur NR, Pavlenko EA, Mwenda N, Sharma K, Francelle L, Mazzulli JR. Rescue of α-synuclein aggregation in Parkinson's patient neurons by synergistic enhancement of ER proteostasis and protein trafficking. Neuron. PMID 34793693 DOI: 10.1016/j.neuron.2021.10.032 |
0.434 |
|
| 2021 |
Stojkovska I, Mazzulli JR. Detection of pathological alpha-synuclein aggregates in human iPSC-derived neurons and tissue. Star Protocols. 2: 100372. PMID 33733241 DOI: 10.1016/j.xpro.2021.100372 |
0.47 |
|
| 2019 |
Cuddy LK, Wani WY, Morella ML, Pitcairn C, Tsutsumi K, Fredriksen K, Justman CJ, Grammatopoulos TN, Belur NR, Zunke F, Subramanian A, Affaneh A, Lansbury PT, Mazzulli JR. Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein. Neuron. PMID 31648898 DOI: 10.1016/J.Neuron.2019.09.001 |
0.472 |
|
| 2019 |
Tsunemi T, Perez-Rosello T, Ishiguro Y, Yoroisaka A, Jeon S, Hamada K, Krishna Vangipuram Suresh M, Wong YC, Xie Z, Akamatsu W, Mazzulli JR, Surmeier DJ, Hattori N, Krainc D. Increased lysosomal exocytosis induced by lysosomal Ca channel agonists protects human dopaminergic neurons from α-synuclein toxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31097622 DOI: 10.1523/Jneurosci.3085-18.2019 |
0.53 |
|
| 2019 |
Zunke F, Mazzulli JR. Modeling neuronopathic storage diseases with patient-derived culture systems. Neurobiology of Disease. PMID 30790616 DOI: 10.1016/J.Nbd.2019.01.018 |
0.438 |
|
| 2018 |
Klein AD, Mazzulli JR. Is Parkinson's disease a lysosomal disorder? Brain : a Journal of Neurology. PMID 29860491 DOI: 10.1093/Brain/Awy147 |
0.447 |
|
| 2018 |
Pitcairn C, Wani WY, Mazzulli JR. Dysregulation of the autophagic-lysosomal pathway in Gaucher and Parkinson's disease. Neurobiology of Disease. PMID 29550539 DOI: 10.1016/J.Nbd.2018.03.008 |
0.545 |
|
| 2017 |
Zunke F, Moise AC, Belur NR, Gelyana E, Stojkovska I, Dzaferbegovic H, Toker NJ, Jeon S, Fredriksen K, Mazzulli JR. Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide. Neuron. PMID 29290548 DOI: 10.1016/J.Neuron.2017.12.012 |
0.546 |
|
| 2017 |
Stojkovska I, Krainc D, Mazzulli JR. Molecular mechanisms of α-synuclein and GBA1 in Parkinson's disease. Cell and Tissue Research. PMID 29064079 DOI: 10.1007/S00441-017-2704-Y |
0.574 |
|
| 2017 |
Mor DE, Tsika E, Mazzulli JR, Gould NS, Kim H, Daniels MJ, Doshi S, Gupta P, Grossman JL, Tan VX, Kalb RG, Caldwell KA, Caldwell GA, Wolfe JH, Ischiropoulos H. Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration. Nature Neuroscience. PMID 28920936 DOI: 10.1038/Nn.4641 |
0.641 |
|
| 2017 |
Burbulla LF, Song P, Mazzulli JR, Zampese E, Wong YC, Jeon S, Santos DP, Blanz J, Obermaier CD, Strojny C, Savas JN, Kiskinis E, Zhuang X, Krüger R, Surmeier DJ, et al. Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease. Science (New York, N.Y.). PMID 28882997 DOI: 10.1126/Science.Aam9080 |
0.562 |
|
| 2016 |
Chung SY, Kishinevsky S, Mazzulli JR, Graziotto J, Mrejeru A, Mosharov EV, Puspita L, Valiulahi P, Sulzer D, Milner TA, Taldone T, Krainc D, Studer L, Shim JW. Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation. Stem Cell Reports. PMID 27641647 DOI: 10.1016/J.Stemcr.2016.08.012 |
0.558 |
|
| 2016 |
Mazzulli JR, Zunke F, Tsunemi T, Toker NJ, Jeon S, Burbulla LF, Patnaik S, Sidransky E, Marugan JJ, Sue CM, Krainc D. Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 7693-706. PMID 27445146 DOI: 10.1523/Jneurosci.0628-16.2016 |
0.571 |
|
| 2016 |
Zunke F, Andresen L, Wesseler S, Groth J, Arnold P, Rothaug M, Mazzulli JR, Krainc D, Blanz J, Saftig P, Schwake M. Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2. Proceedings of the National Academy of Sciences of the United States of America. PMID 27001828 DOI: 10.1073/Pnas.1514005113 |
0.439 |
|
| 2016 |
Mazzulli JR, Zunke F, Isacson O, Studer L, Krainc D. α-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models. Proceedings of the National Academy of Sciences of the United States of America. PMID 26839413 DOI: 10.1073/Pnas.1520335113 |
0.579 |
|
| 2016 |
Mazzulli JR, Burbulla LF, Krainc D, Ischiropoulos H. Detection of Free and Protein-Bound ortho-Quinones by Near-Infrared Fluorescence. Analytical Chemistry. 88: 2399-405. PMID 26813311 DOI: 10.1021/Acs.Analchem.5B04420 |
0.61 |
|
| 2014 |
Rothaug M, Zunke F, Mazzulli JR, Schweizer M, Altmeppen H, Lüllmann-Rauch R, Kallemeijn WW, Gaspar P, Aerts JM, Glatzel M, Saftig P, Krainc D, Schwake M, Blanz J. LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance. Proceedings of the National Academy of Sciences of the United States of America. 111: 15573-8. PMID 25316793 DOI: 10.1073/Pnas.1405700111 |
0.549 |
|
| 2014 |
Knight AL, Yan X, Hamamichi S, Ajjuri RR, Mazzulli JR, Zhang MW, Daigle JG, Zhang S, Borom AR, Roberts LR, Lee SK, DeLeon SM, Viollet-Djelassi C, Krainc D, O'Donnell JM, et al. The glycolytic enzyme, GPI, is a functionally conserved modifier of dopaminergic neurodegeneration in Parkinson's models. Cell Metabolism. 20: 145-57. PMID 24882066 DOI: 10.1016/J.Cmet.2014.04.017 |
0.42 |
|
| 2013 |
Chung CY, Khurana V, Auluck PK, Tardiff DF, Mazzulli JR, Soldner F, Baru V, Lou Y, Freyzon Y, Cho S, Mungenast AE, Muffat J, Mitalipova M, Pluth MD, Jui NT, et al. Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science (New York, N.Y.). 342: 983-7. PMID 24158904 DOI: 10.1126/Science.1245296 |
0.535 |
|
| 2013 |
Schultheis PJ, Fleming SM, Clippinger AK, Lewis J, Tsunemi T, Giasson B, Dickson DW, Mazzulli JR, Bardgett ME, Haik KL, Ekhator O, Chava AK, Howard J, Gannon M, Hoffman E, et al. Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits. Human Molecular Genetics. 22: 2067-82. PMID 23393156 DOI: 10.1093/Hmg/Ddt057 |
0.521 |
|
| 2013 |
Kumar KR, Ramirez A, Göbel A, Kresojević N, Svetel M, Lohmann K, M Sue C, Rolfs A, Mazzulli JR, Alcalay RN, Krainc D, Klein C, Kostic V, Grünewald A. Glucocerebrosidase mutations in a Serbian Parkinson's disease population. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 20: 402-5. PMID 22812582 DOI: 10.1111/J.1468-1331.2012.03817.X |
0.417 |
|
| 2012 |
Cooper O, Seo H, Andrabi S, Guardia-Laguarta C, Graziotto J, Sundberg M, McLean JR, Carrillo-Reid L, Xie Z, Osborn T, Hargus G, Deleidi M, Lawson T, Bogetofte H, Perez-Torres E, ... ... Mazzulli J, et al. Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Science Translational Medicine. 4: 141ra90. PMID 22764206 DOI: 10.1126/Scitranslmed.3003985 |
0.442 |
|
| 2012 |
Usenovic M, Tresse E, Mazzulli JR, Taylor JP, Krainc D. Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 4240-6. PMID 22442086 DOI: 10.1523/Jneurosci.5575-11.2012 |
0.484 |
|
| 2012 |
Jeong H, Cohen DE, Cui L, Supinski A, Savas JN, Mazzulli JR, Yates JR, Bordone L, Guarente L, Krainc D. Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway. Nature Medicine. 18: 159-65. PMID 22179316 DOI: 10.1038/Nm.2559 |
0.378 |
|
| 2012 |
Palada V, Terzić J, Mazzulli J, Bwala G, Hagenah J, Peterlin B, Hung AY, Klein C, Krainc D. Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease. Neurobiology of Aging. 33: 836.e1-3. PMID 21794955 DOI: 10.1016/J.Neurobiolaging.2011.06.015 |
0.419 |
|
| 2012 |
Mazzulli J, Krainc D. A Mechanistic Connection Between Gaucher Disease and the Synucleinopathies Molecular Genetics and Metabolism. 105: S46. DOI: 10.1016/J.Ymgme.2011.11.112 |
0.308 |
|
| 2011 |
Cao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS. Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells. Science Translational Medicine. 3: 89ra58. PMID 21715679 DOI: 10.1126/Scitranslmed.3002346 |
0.33 |
|
| 2011 |
Mazzulli JR, Xu YH, Sun Y, Knight AL, McLean PJ, Caldwell GA, Sidransky E, Grabowski GA, Krainc D. Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies. Cell. 146: 37-52. PMID 21700325 DOI: 10.1016/J.Cell.2011.06.001 |
0.55 |
|
| 2010 |
Tsika E, Moysidou M, Guo J, Cushman M, Gannon P, Sandaltzopoulos R, Giasson BI, Krainc D, Ischiropoulos H, Mazzulli JR. Distinct region-specific alpha-synuclein oligomers in A53T transgenic mice: implications for neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 3409-18. PMID 20203200 DOI: 10.1523/Jneurosci.4977-09.2010 |
0.601 |
|
| 2009 |
Waxman EA, Mazzulli JR, Giasson BI. Characterization of hydrophobic residue requirements for alpha-synuclein fibrillization. Biochemistry. 48: 9427-36. PMID 19722699 DOI: 10.1021/Bi900539P |
0.462 |
|
| 2009 |
Jeong H, Then F, Melia TJ, Mazzulli JR, Cui L, Savas JN, Voisine C, Paganetti P, Tanese N, Hart AC, Yamamoto A, Krainc D. Acetylation targets mutant huntingtin to autophagosomes for degradation. Cell. 137: 60-72. PMID 19345187 DOI: 10.1016/J.Cell.2009.03.018 |
0.391 |
|
| 2008 |
Martinez-Vicente M, Talloczy Z, Kaushik S, Massey AC, Mazzulli J, Mosharov EV, Hodara R, Fredenburg R, Wu DC, Follenzi A, Dauer W, Przedborski S, Ischiropoulos H, Lansbury PT, Sulzer D, et al. Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. The Journal of Clinical Investigation. 118: 777-88. PMID 18172548 DOI: 10.1172/Jci32806 |
0.667 |
|
| 2007 |
Mazzulli JR, Armakola M, Dumoulin M, Parastatidis I, Ischiropoulos H. Cellular oligomerization of alpha-synuclein is determined by the interaction of oxidized catechols with a C-terminal sequence. The Journal of Biological Chemistry. 282: 31621-30. PMID 17785456 DOI: 10.1074/Jbc.M704737200 |
0.634 |
|
| 2006 |
Mazzulli JR, Mishizen AJ, Giasson BI, Lynch DR, Thomas SA, Nakashima A, Nagatsu T, Ota A, Ischiropoulos H. Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10068-78. PMID 17005870 DOI: 10.1523/Jneurosci.0896-06.2006 |
0.647 |
|
| 2002 |
Maeda T, Mazzulli JR, Farrance IK, Stewart AF. Mouse DTEF-1 (ETFR-1, TEF-5) is a transcriptional activator in alpha 1-adrenergic agonist-stimulated cardiac myocytes. The Journal of Biological Chemistry. 277: 24346-52. PMID 11986313 DOI: 10.1074/Jbc.M201171200 |
0.329 |
|
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