Jean-Pierre Vilardaga - Publications

1999-2005 Pharmacology University of Pittsburgh, Pittsburgh, PA, United States 

65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 McGarvey JC, Xiao K, Bowman SL, Mamonova T, Zhang Q, Bisello A, Sneddon WB, Ardura JA, Jean-Alphonse F, Vilardaga JP, Puthenveedu MA, Friedman PA. Actin-Sorting Nexin 27-Retromer Complex Mediates Rapid Parathyroid Hormone Receptor Recycling. The Journal of Biological Chemistry. PMID 27008860 DOI: 10.1074/jbc.M115.697045  0.72
2016 Gidon A, Feinstein TN, Xiao K, Vilardaga JP. Studying the regulation of endosomal cAMP production in GPCR signaling. Methods in Cell Biology. 132: 109-26. PMID 26928541 DOI: 10.1016/bs.mcb.2015.10.007  0.72
2015 Cheloha RW, Gellman SH, Vilardaga JP, Gardella TJ. PTH receptor-1 signalling-mechanistic insights and therapeutic prospects. Nature Reviews. Endocrinology. PMID 26303600 DOI: 10.1038/nrendo.2015.139  0.72
2015 Gardella TJ, Vilardaga JP. International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors. Pharmacological Reviews. 67: 310-37. PMID 25713287 DOI: 10.1124/pr.114.009464  0.72
2014 Vilardaga JP, Jean-Alphonse FG, Gardella TJ. Endosomal generation of cAMP in GPCR signaling. Nature Chemical Biology. 10: 700-6. PMID 25271346 DOI: 10.1038/nchembio.1611  0.72
2014 Fernández-Dueñas V, Gómez-Soler M, López-Cano M, Taura JJ, Ledent C, Watanabe M, Jacobson KA, Vilardaga JP, Ciruela F. Uncovering caffeine's adenosine A2A receptor inverse agonism in experimental parkinsonism. Acs Chemical Biology. 9: 2496-501. PMID 25268872 DOI: 10.1021/cb5005383  0.72
2014 Gidon A, Al-Bataineh MM, Jean-Alphonse FG, Stevenson HP, Watanabe T, Louet C, Khatri A, Calero G, Pastor-Soler NM, Gardella TJ, Vilardaga JP. Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase. Nature Chemical Biology. 10: 707-9. PMID 25064832 DOI: 10.1038/nchembio.1589  0.72
2013 Leslie KL, Song GJ, Barrick S, Wehbi VL, Vilardaga JP, Bauer PM, Bisello A. Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) and nuclear factor-κB (NF-κB): a feed-forward loop for systemic and vascular inflammation. The Journal of Biological Chemistry. 288: 36426-36. PMID 24196963 DOI: 10.1074/jbc.M113.483339  0.72
2013 Feinstein TN, Yui N, Webber MJ, Wehbi VL, Stevenson HP, King JD, Hallows KR, Brown D, Bouley R, Vilardaga JP. Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin. The Journal of Biological Chemistry. 288: 27849-60. PMID 23935101 DOI: 10.1074/jbc.M112.445098  0.72
2013 Vilardaga JP, Romero G, Feinstein TN, Wehbi VL. Kinetics and dynamics in the G protein-coupled receptor signaling cascade. Methods in Enzymology. 522: 337-63. PMID 23374192 DOI: 10.1016/B978-0-12-407865-9.00016-9  0.72
2013 Wehbi VL, Stevenson HP, Feinstein TN, Calero G, Romero G, Vilardaga JP. Noncanonical GPCR signaling arising from a PTH receptor-arrestin-Gβγ complex. Proceedings of the National Academy of Sciences of the United States of America. 110: 1530-5. PMID 23297229 DOI: 10.1073/pnas.1205756110  0.72
2012 Vilardaga JP, Gardella TJ, Wehbi VL, Feinstein TN. Non-canonical signaling of the PTH receptor. Trends in Pharmacological Sciences. 33: 423-31. PMID 22709554 DOI: 10.1016/  0.72
2012 Hanyu R, Wehbi VL, Hayata T, Moriya S, Feinstein TN, Ezura Y, Nagao M, Saita Y, Hemmi H, Notomi T, Nakamoto T, Schipani E, Takeda S, Kaneko K, Kurosawa H, ... ... Vilardaga JP, et al. Anabolic action of parathyroid hormone regulated by the β2-adrenergic receptor. Proceedings of the National Academy of Sciences of the United States of America. 109: 7433-8. PMID 22538810 DOI: 10.1073/pnas.1109036109  0.72
2011 Nagao M, Feinstein TN, Ezura Y, Hayata T, Notomi T, Saita Y, Hanyu R, Hemmi H, Izu Y, Takeda S, Wang K, Rittling S, Nakamoto T, Kaneko K, Kurosawa H, ... ... Vilardaga JP, et al. Sympathetic control of bone mass regulated by osteopontin. Proceedings of the National Academy of Sciences of the United States of America. 108: 17767-72. PMID 21990347 DOI: 10.1073/pnas.1109402108  0.72
2011 Liu Z, Turan S, Wehbi VL, Vilardaga JP, Bastepe M. Extra-long Gαs variant XLαs protein escapes activation-induced subcellular redistribution and is able to provide sustained signaling. The Journal of Biological Chemistry. 286: 38558-69. PMID 21890629 DOI: 10.1074/jbc.M111.240150  0.72
2011 Vilardaga JP. Studying ligand efficacy at G protein-coupled receptors using FRET. Methods in Molecular Biology (Clifton, N.J.). 756: 133-48. PMID 21870223 DOI: 10.1007/978-1-61779-160-4_6  0.72
2011 Ardura JA, Wang B, Watkins SC, Vilardaga JP, Friedman PA. Dynamic Na+-H+ exchanger regulatory factor-1 association and dissociation regulate parathyroid hormone receptor trafficking at membrane microdomains. The Journal of Biological Chemistry. 286: 35020-9. PMID 21832055 DOI: 10.1074/jbc.M111.264978  0.72
2011 Chen S, Webber MJ, Vilardaga JP, Khatri A, Brown D, Ausiello DA, Lin HY, Bouley R. Visualizing microtubule-dependent vasopressin type 2 receptor trafficking using a new high-affinity fluorescent vasopressin ligand. Endocrinology. 152: 3893-904. PMID 21828182 DOI: 10.1210/en.2011-1049  0.72
2011 Vilardaga JP. Recording kinetics of adrenergic receptor activation in live cells. Current Topics in Membranes. 67: 101-11. PMID 21771487 DOI: 10.1016/B978-0-12-384921-2.00005-7  0.72
2011 Feinstein TN, Wehbi VL, Ardura JA, Wheeler DS, Ferrandon S, Gardella TJ, Vilardaga JP. Retromer terminates the generation of cAMP by internalized PTH receptors. Nature Chemical Biology. 7: 278-84. PMID 21445058 DOI: 10.1038/nchembio.545  0.72
2011 Vilardaga JP, Romero G, Friedman PA, Gardella TJ. Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm. Cellular and Molecular Life Sciences : Cmls. 68: 1-13. PMID 20703892 DOI: 10.1007/s00018-010-0465-9  0.72
2010 Vilardaga JP, Agnati LF, Fuxe K, Ciruela F. G-protein-coupled receptor heteromer dynamics. Journal of Cell Science. 123: 4215-20. PMID 21123619 DOI: 10.1242/jcs.063354  0.72
2010 Vilardaga JP. Theme and variations on kinetics of GPCR activation/deactivation. Journal of Receptor and Signal Transduction Research. 30: 304-12. PMID 20836728 DOI: 10.3109/10799893.2010.509728  0.72
2010 Klenk C, Vetter T, Zürn A, Vilardaga JP, Friedman PA, Wang B, Lohse MJ. Formation of a ternary complex among NHERF1, beta-arrestin, and parathyroid hormone receptor. The Journal of Biological Chemistry. 285: 30355-62. PMID 20656684 DOI: 10.1074/jbc.M110.114900  0.72
2010 Ciruela F, Vilardaga JP, Fernández-Dueñas V. Lighting up multiprotein complexes: lessons from GPCR oligomerization. Trends in Biotechnology. 28: 407-15. PMID 20542584 DOI: 10.1016/j.tibtech.2010.05.002  0.72
2010 Agnati LF, Guidolin D, Vilardaga JP, Ciruela F, Fuxe K. On the expanding terminology in the GPCR field: the meaning of receptor mosaics and receptor heteromers. Journal of Receptor and Signal Transduction Research. 30: 287-303. PMID 20429829 DOI: 10.3109/10799891003786226  0.72
2009 Ferrandon S, Feinstein TN, Castro M, Wang B, Bouley R, Potts JT, Gardella TJ, Vilardaga JP. Sustained cyclic AMP production by parathyroid hormone receptor endocytosis. Nature Chemical Biology. 5: 734-42. PMID 19701185 DOI: 10.1038/nchembio.206  0.72
2009 Kawada K, Upadhyay G, Ferandon S, Janarthanan S, Hall M, Vilardaga JP, Yajnik V. Cell migration is regulated by platelet-derived growth factor receptor endocytosis. Molecular and Cellular Biology. 29: 4508-18. PMID 19528233 DOI: 10.1128/MCB.00015-09  0.72
2009 Brea J, Castro M, Giraldo J, López-Giménez JF, Padín JF, Quintián F, Cadavid MI, Vilaró MT, Mengod G, Berg KA, Clarke WP, Vilardaga JP, Milligan G, Loza MI. Evidence for distinct antagonist-revealed functional states of 5-hydroxytryptamine(2A) receptor homodimers. Molecular Pharmacology. 75: 1380-91. PMID 19279328 DOI: 10.1124/mol.108.054395  0.72
2009 Vilardaga JP, Bünemann M, Feinstein TN, Lambert N, Nikolaev VO, Engelhardt S, Lohse MJ, Hoffmann C. GPCR and G proteins: drug efficacy and activation in live cells. Molecular Endocrinology (Baltimore, Md.). 23: 590-9. PMID 19196832 DOI: 10.1210/me.2008-0204  0.72
2009 Zürn A, Zabel U, Vilardaga JP, Schindelin H, Lohse MJ, Hoffmann C. Fluorescence resonance energy transfer analysis of alpha 2a-adrenergic receptor activation reveals distinct agonist-specific conformational changes. Molecular Pharmacology. 75: 534-41. PMID 19106230 DOI: 10.1124/mol.108.052399  0.72
2008 Okazaki M, Ferrandon S, Vilardaga JP, Bouxsein ML, Potts JT, Gardella TJ. Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation. Proceedings of the National Academy of Sciences of the United States of America. 105: 16525-30. PMID 18946036 DOI: 10.1073/pnas.0808750105  0.72
2008 Zalyapin EA, Bouley R, Hasler U, Vilardaga JP, Lin HY, Brown D, Ausiello DA. Effects of the renal medullary pH and ionic environment on vasopressin binding and signaling. Kidney International. 74: 1557-67. PMID 18813286 DOI: 10.1038/ki.2008.412  0.72
2008 Lohse MJ, Nikolaev VO, Hein P, Hoffmann C, Vilardaga JP, Bünemann M. Optical techniques to analyze real-time activation and signaling of G-protein-coupled receptors. Trends in Pharmacological Sciences. 29: 159-65. PMID 18262662 DOI: 10.1016/  0.72
2008 Lohse MJ, Hein P, Hoffmann C, Nikolaev VO, Vilardaga JP, Bünemann M. Kinetics of G-protein-coupled receptor signals in intact cells. British Journal of Pharmacology. 153: S125-32. PMID 18193071 DOI: 10.1038/sj.bjp.0707656  0.72
2008 Vilardaga JP, Nikolaev VO, Lorenz K, Ferrandon S, Zhuang Z, Lohse MJ. Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling. Nature Chemical Biology. 4: 126-31. PMID 18193048 DOI: 10.1038/nchembio.64  0.72
2008 Dean T, Vilardaga JP, Potts JT, Gardella TJ. Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor. Molecular Endocrinology (Baltimore, Md.). 22: 156-66. PMID 17872377 DOI: 10.1210/me.2007-0274  0.72
2008 Okazaki M, Ferrandon S, Vilardaga JP, Bouxsein ML, Potts JT, Gardella TJ. Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation (Proceedings of the National Academy of Sciences of the United States of America (October 28, 2008) 105: 43 10.1073/pnas.0808750105) Proceedings of the National Academy of Sciences of the United States of America. 105: 20559. DOI: 10.1073/pnas.0811217106  0.72
2007 Lohse MJ, Bünemann M, Hoffmann C, Vilardaga JP, Nikolaev VO. Monitoring receptor signaling by intramolecular FRET. Current Opinion in Pharmacology. 7: 547-53. PMID 17919975 DOI: 10.1016/j.coph.2007.08.007  0.72
2007 Lohse MJ, Hoffmann C, Nikolaev VO, Vilardaga JP, Bünemann M. Kinetic analysis of G protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells. Advances in Protein Chemistry. 74: 167-88. PMID 17854658 DOI: 10.1016/S0065-3233(07)74005-6  0.72
2007 Rochais F, Vilardaga JP, Nikolaev VO, Bünemann M, Lohse MJ, Engelhardt S. Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol. The Journal of Clinical Investigation. 117: 229-35. PMID 17200720 DOI: 10.1172/JCI30012  0.72
2006 Vilardaga JP. Switching modes for G protein-coupled receptor activation. Nature Chemical Biology. 2: 395-6. PMID 16850011 DOI: 10.1038/nchembio0806-395  0.72
2006 Nikolaev VO, Hoffmann C, Bünemann M, Lohse MJ, Vilardaga JP. Molecular basis of partial agonism at the neurotransmitter alpha2A-adrenergic receptor and Gi-protein heterotrimer. The Journal of Biological Chemistry. 281: 24506-11. PMID 16787921 DOI: 10.1074/jbc.M603266200  0.72
2005 Vilardaga JP, Steinmeyer R, Harms GS, Lohse MJ. Molecular basis of inverse agonism in a G protein-coupled receptor. Nature Chemical Biology. 1: 25-8. PMID 16407989 DOI: 10.1038/nchembio705  0.72
2005 Castro M, Nikolaev VO, Palm D, Lohse MJ, Vilardaga JP. Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism. Proceedings of the National Academy of Sciences of the United States of America. 102: 16084-9. PMID 16236727 DOI: 10.1073/pnas.0503942102  0.72
2005 Hoffmann C, Gaietta G, Bünemann M, Adams SR, Oberdorff-Maass S, Behr B, Vilardaga JP, Tsien RY, Ellisman MH, Lohse MJ. A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells. Nature Methods. 2: 171-6. PMID 15782185 DOI: 10.1038/nmeth742  0.72
2004 Krasel C, Vilardaga JP, Bünemann M, Lohse MJ. Kinetics of G-protein-coupled receptor signalling and desensitization. Biochemical Society Transactions. 32: 1029-31. PMID 15506955 DOI: 10.1042/BST0321029  0.72
2003 Lohse MJ, Vilardaga JP, Bünemann M. Molecular mechanisms of receptor activation: real-time analysis by fluorescence resonance energy transfer. Autonomic & Autacoid Pharmacology. 23: 231-3. PMID 15134067  0.72
2003 Lohse MJ, Vilardaga JP, Bünemann M. Direct optical recording of intrinsic efficacy at a G protein-coupled receptor. Life Sciences. 74: 397-404. PMID 14607268 DOI: 10.1016/j.lfs.2003.09.026  0.72
2003 Vilardaga JP, Bünemann M, Krasel C, Castro M, Lohse MJ. Measurement of the millisecond activation switch of G protein-coupled receptors in living cells. Nature Biotechnology. 21: 807-12. PMID 12808462 DOI: 10.1038/nbt838  0.72
2002 Castro M, Dicker F, Vilardaga JP, Krasel C, Bernhardt M, Lohse MJ. Dual regulation of the parathyroid hormone (PTH)/PTH-related peptide receptor signaling by protein kinase C and beta-arrestins. Endocrinology. 143: 3854-65. PMID 12239097 DOI: 10.1210/en.2002-220232  0.72
2002 Vilardaga JP, Krasel C, Chauvin S, Bambino T, Lohse MJ, Nissenson RA. Internalization determinants of the parathyroid hormone receptor differentially regulate beta-arrestin/receptor association. The Journal of Biological Chemistry. 277: 8121-9. PMID 11726668 DOI: 10.1074/jbc.M110433200  0.72
2001 Vilardaga JP, Lin I, Nissenson RA. Analysis of parathyroid hormone (PTH)/secretin receptor chimeras differentiates the role of functional domains in the pth/ pth-related peptide (PTHrP) receptor on hormone binding and receptor activation. Molecular Endocrinology (Baltimore, Md.). 15: 1186-99. PMID 11435617 DOI: 10.1210/mend.15.7.0665  0.72
2001 Vilardaga JP, Frank M, Krasel C, Dees C, Nissenson RA, Lohse MJ. Differential conformational requirements for activation of G proteins and the regulatory proteins arrestin and G protein-coupled receptor kinase in the G protein-coupled receptor for parathyroid hormone (PTH)/PTH-related protein. The Journal of Biological Chemistry. 276: 33435-43. PMID 11387315 DOI: 10.1074/jbc.M011495200  0.72
1999 Di Paolo E, Vilardaga JP, Petry H, Moguilevsky N, Bollen A, Robberecht P, Waelbroeck M. Role of charged amino acids conserved in the vasoactive intestinal polypeptide/secretin family of receptors on the secretin receptor functionality. Peptides. 20: 1187-93. PMID 10573290 DOI: 10.1016/S0196-9781(99)00122-9  0.72
1997 Vilardaga JP, Di Paolo E, Bialek C, De Neef P, Waelbroeck M, Bollen A, Robberecht P. Mutational analysis of extracellular cysteine residues of rat secretin receptor shows that disulfide bridges are essential for receptor function. European Journal of Biochemistry / Febs. 246: 173-80. PMID 9210480  0.72
1997 Vilardaga JP, Ujlaml L, Nissenson RA. Structure-function analysis of pth receptor, a class ii g protein-coupled receptor Faseb Journal. 11: A1332.  0.72
1996 Gourlet P, Vilardaga JP, De Neef P, Waelbroeck M, Vandermeers A, Robberecht P. The C-terminus ends of secretin and VIP interact with the N-terminal domains of their receptors. Peptides. 17: 825-9. PMID 8844773 DOI: 10.1016/0196-9781(96)00107-6  0.72
1996 Gourlet P, Vilardaga JP, De Neef P, Vandermeers A, Waelbroeck M, Bollen A, Robberecht P. Interaction of amino acid residues at positions 8-15 of secretin with the N-terminal domain of the secretin receptor. European Journal of Biochemistry / Febs. 239: 349-55. PMID 8706739  0.72
1996 Vilardaga JP, di Paolo E, de Neef P, Waelbroeck M, Bollen A, Robberecht P. Lysine 173 residue within the first exoloop of rat secretin receptor is involved in carboxylate moiety recognition of Asp 3 in secretin. Biochemical and Biophysical Research Communications. 218: 842-6. PMID 8579602 DOI: 10.1006/bbrc.1996.0150  0.72
1995 Ciccarelli E, Svoboda M, De Neef P, Di Paolo E, Bollen A, Dubeaux C, Vilardaga JP, Waelbroeck M, Robberecht P. Pharmacological properties of two recombinant splice variants of the PACAP type I receptor, transfected and stably expressed in CHO cells. European Journal of Pharmacology. 288: 259-67. PMID 7774670 DOI: 10.1016/0922-4106(95)90037-3  0.72
1995 Vilardaga JP, Di Paolo E, Bollen A. Improved PCR method for high-efficiency site-directed mutagenesis using class 2S restriction enzymes. Biotechniques. 18: 604-6. PMID 7598888  0.72
1995 Vilardaga JP, De Neef P, Di Paolo E, Bollen A, Waelbroeck M, Robberecht P. Properties of chimeric secretin and VIP receptor proteins indicate the importance of the N-terminal domain for ligand discrimination. Biochemical and Biophysical Research Communications. 211: 885-91. PMID 7598719 DOI: 10.1006/bbrc.1995.1895  0.72
1994 Vilardaga JP, Ciccarelli E, Dubeaux C, De Neef P, Bollen A, Robberecht P. Properties and regulation of the coupling to adenylate cyclase of secretin receptors stably transfected in Chinese hamster ovary cells. Molecular Pharmacology. 45: 1022-8. PMID 8190092  0.72
1994 Ciccarelli E, Vilardaga JP, De Neef P, Di Paolo E, Waelbroeck M, Bollen A, Robberecht P. Properties of the VIP-PACAP type II receptor stably expressed in CHO cells. Regulatory Peptides. 54: 397-407. PMID 7716273 DOI: 10.1016/0167-0115(94)90537-1  0.72
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