Thomas Stephen Otis, PhD - Publications

Affiliations: 
1998-2015 University of California, Los Angeles, Los Angeles, CA 
 2015-2017 PRED Roche Pharma 
 2017- Sainsbury Wellcome Centre University College London 

74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Brown AS, Meera P, Altindag B, Chopra R, Perkins EM, Paul S, Scoles DR, Tarapore E, Magri J, Huang H, Jackson M, Shakkottai VG, Otis TS, Pulst SM, Atwood SX, et al. MTSS1/Src family kinase dysregulation underlies multiple inherited ataxias. Proceedings of the National Academy of Sciences of the United States of America. PMID 30530649 DOI: 10.1073/pnas.1816177115  1
2018 Sanders SJ, Campbell AJ, Cottrell JR, Moller RS, Wagner FF, Auldridge AL, Bernier RA, Catterall WA, Chung WK, Empfield JR, George AL, Hipp JF, Khwaja O, Kiskinis E, Lal D, ... ... Otis TS, et al. Progress in Understanding and Treating SCN2A-Mediated Disorders. Trends in Neurosciences. PMID 29691040 DOI: 10.1016/j.tins.2018.03.011  1
2018 Choe KY, Sanchez CF, Harris NG, Otis TS, Mathews PJ. Optogenetic fMRI and electrophysiological identification of region-specific connectivity between the cerebellar cortex and forebrain. Neuroimage. PMID 29496611 DOI: 10.1016/j.neuroimage.2018.02.047  1
2017 Zhang N, Peng Z, Tong X, Kerstin Lindemeyer A, Cetina Y, Huang CS, Olsen RW, Otis TS, Houser CR. Decreased surface expression of the δ subunit of the GABAA receptor contributes to reduced tonic inhibition in dentate granule cells in a mouse model of fragile X syndrome. Experimental Neurology. PMID 28822839 DOI: 10.1016/j.expneurol.2017.08.008  1
2017 Pflieger LT, Dansithong W, Paul S, Scoles D, Figueroa KP, Meera P, Otis TS, Facelli JC, Pulst SM. Gene Co-Expression Network Analysis for Identifying Modules and Functionally Enriched Pathways in SCA2. Human Molecular Genetics. PMID 28525545 DOI: 10.1093/hmg/ddx191  1
2017 Meera P, Pulst S, Otis T. A positive feedback loop linking enhanced mGluR function and basal calcium in spinocerebellar ataxia type 2. Elife. 6. PMID 28518055 DOI: 10.7554/eLife.26377  1
2017 Scoles DR, Meera P, Schneider MD, Paul S, Dansithong W, Figueroa KP, Hung G, Rigo F, Bennett CF, Otis TS, Pulst SM. Antisense oligonucleotide therapy for spinocerebellar ataxia type 2. Nature. PMID 28405024 DOI: 10.1038/nature22044  1
2016 Meera P, Pulst SM, Otis TS. Cellular and circuit mechanisms underlying spinocerebellar ataxias. The Journal of Physiology. PMID 27198167 DOI: 10.1113/JP271897  1
2016 Lang EJ, Apps R, Bengtsson F, Cerminara NL, De Zeeuw CI, Ebner TJ, Heck DH, Jaeger D, Jörntell H, Kawato M, Otis TS, Ozyildirim O, Popa LS, Reeves AM, Schweighofer N, et al. The Roles of the Olivocerebellar Pathway in Motor Learning and Motor Control. A Consensus Paper. Cerebellum (London, England). PMID 27193702 DOI: 10.1007/s12311-016-0787-8  1
2015 Tong X, Peng Z, Zhang N, Cetina Y, Huang CS, Wallner M, Otis TS, Houser CR. Ectopic Expression of α6 and δ GABAA Receptor Subunits in Hilar Somatostatin Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 16142-58. PMID 26658866 DOI: 10.1523/JNEUROSCI.2853-15.2015  1
2015 Lee KH, Mathews PJ, Reeves AM, Choe KY, Jami SA, Serrano RE, Otis TS. Circuit mechanisms underlying motor memory formation in the cerebellum. Neuron. 86: 529-40. PMID 25843404 DOI: 10.1016/j.neuron.2015.03.010  1
2015 Shtrahman M, Aharoni DB, Hardy NF, Buonomano DV, Arisaka K, Otis TS. Multifocal fluorescence microscope for fast optical recordings of neuronal action potentials. Biophysical Journal. 108: 520-9. PMID 25650920 DOI: 10.1016/j.bpj.2014.12.005  1
2013 Reeber SL, Otis TS, Sillitoe RV. New roles for the cerebellum in health and disease. Frontiers in Systems Neuroscience. 7: 83. PMID 24294192 DOI: 10.3389/fnsys.2013.00083  1
2013 Sareen D, O'Rourke JG, Meera P, Muhammad AK, Grant S, Simpkinson M, Bell S, Carmona S, Ornelas L, Sahabian A, Gendron T, Petrucelli L, Baughn M, Ravits J, Harms MB, ... ... Otis TS, et al. Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion. Science Translational Medicine. 5: 208ra149. PMID 24154603 DOI: 10.1126/scitranslmed.3007529  1
2013 Peng Z, Zhang N, Wei W, Huang CS, Cetina Y, Otis TS, Houser CR. A reorganized GABAergic circuit in a model of epilepsy: evidence from optogenetic labeling and stimulation of somatostatin interneurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 14392-405. PMID 24005292 DOI: 10.1523/JNEUROSCI.2045-13.2013  1
2013 Santhakumar V, Meera P, Karakossian MH, Otis TS. A reinforcing circuit action of extrasynaptic GABAA receptor modulators on cerebellar granule cell inhibition. Plos One. 8: e72976. PMID 23977374 DOI: 10.1371/journal.pone.0072976  1
2013 Hansen ST, Meera P, Otis TS, Pulst SM. Changes in Purkinje cell firing and gene expression precede behavioral pathology in a mouse model of SCA2. Human Molecular Genetics. 22: 271-83. PMID 23087021 DOI: 10.1093/hmg/dds427  1
2012 Pulst SM, Otis TS. Repolarization matters: mutations in the Kv4.3 potassium channel cause SCA19/22. Annals of Neurology. 72: 829-31. PMID 23280833 DOI: 10.1002/ana.23803  1
2012 Mathews PJ, Lee KH, Peng Z, Houser CR, Otis TS. Effects of climbing fiber driven inhibition on Purkinje neuron spiking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 17988-97. PMID 23238715 DOI: 10.1523/JNEUROSCI.3916-12.2012  1
2012 Otis TS, Mathews PJ, Lee KH, Maiz J. How do climbing fibers teach? Frontiers in Neural Circuits. 6: 95. PMID 23226116 DOI: 10.3389/fncir.2012.00095  1
2012 Yue L, Pawlowski M, Dellal SS, Xie A, Feng F, Otis TS, Bruzik KS, Qian H, Pepperberg DR. Robust photoregulation of GABA(A) receptors by allosteric modulation with a propofol analogue. Nature Communications. 3: 1095. PMID 23033071 DOI: 10.1038/ncomms2094  1
2012 Maiz J, Karakossian MH, Pakaprot N, Robleto K, Thompson RF, Otis TS. Prolonging the postcomplex spike pause speeds eyeblink conditioning. Proceedings of the National Academy of Sciences of the United States of America. 109: 16726-30. PMID 22988089 DOI: 10.1073/pnas.1214274109  1
2012 Fink AE, Bender KJ, Trussell LO, Otis TS, DiGregorio DA. Two-photon compatibility and single-voxel, single-trial detection of subthreshold neuronal activity by a two-component optical voltage sensor. Plos One. 7: e41434. PMID 22870221 DOI: 10.1371/journal.pone.0041434  1
2012 Dellal SS, Luo R, Otis TS. GABAA receptors increase excitability and conduction velocity of cerebellar parallel fiber axons. Journal of Neurophysiology. 107: 2958-70. PMID 22378171 DOI: 10.1152/jn.01028.2011  1
2012 Gehman LT, Meera P, Stoilov P, Shiue L, O'Brien JE, Meisler MH, Ares M, Otis TS, Black DL. The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function. Genes & Development. 26: 445-60. PMID 22357600 DOI: 10.1101/gad.182477.111  1
2011 Meera P, Wallner M, Otis TS. Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABA(A) receptors. Journal of Neurophysiology. 106: 2057-64. PMID 21795619 DOI: 10.1152/jn.00450.2011  1
2011 Kruger L, Otis TS, Shtrahman M. Golgi in retrospect: a historiographic examination of contextual influence in tracing the constructs of neuronal organization. Brain Research Reviews. 66: 68-74. PMID 20637231 DOI: 10.1016/j.brainresrev.2010.07.001  1
2010 Meera P, Olsen RW, Otis TS, Wallner M. Alcohol- and alcohol antagonist-sensitive human GABAA receptors: tracking δ subunit incorporation into functional receptors. Molecular Pharmacology. 78: 918-24. PMID 20699325 DOI: 10.1124/mol.109.062687  1
2010 Otis TS, Dodson PD. Transporter Proteins in Neurons and Glia Encyclopedia of Neuroscience. 1159-1166. DOI: 10.1016/B978-008045046-9.01211-0  1
2009 Bradley J, Luo R, Otis TS, DiGregorio DA. Submillisecond optical reporting of membrane potential in situ using a neuronal tracer dye. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 9197-209. PMID 19625510 DOI: 10.1523/JNEUROSCI.1240-09.2009  1
2009 Meera P, Olsen RW, Otis TS, Wallner M. Etomidate, propofol and the neurosteroid THDOC increase the GABA efficacy of recombinant alpha4beta3delta and alpha4beta3 GABA A receptors expressed in HEK cells. Neuropharmacology. 56: 155-60. PMID 18778723 DOI: 10.1016/j.neuropharm.2008.08.011  1
2008 Lutz C, Otis TS, DeSars V, Charpak S, DiGregorio DA, Emiliani V. Holographic photolysis of caged neurotransmitters. Nature Methods. 5: 821-7. PMID 19160517 DOI: 10.1038/nmeth.1241  1
2008 Otis TS, Sofroniew MV. Glia get excited. Nature Neuroscience. 11: 379-80. PMID 18368040 DOI: 10.1038/nn0408-379  1
2008 Fortin DL, Banghart MR, Dunn TW, Borges K, Wagenaar DA, Gaudry Q, Karakossian MH, Otis TS, Kristan WB, Trauner D, Kramer RH. Photochemical control of endogenous ion channels and cellular excitability. Nature Methods. 5: 331-8. PMID 18311146 DOI: 10.1038/nmeth.1187  1
2008 Otis TS. Comments on "Ethanol sensitivity of GABAergic currents in cerebellar granule neurons is not increased by a single amino acid change (R100Q) in the alpha6 GABA(A) receptor subunit". The Journal of Pharmacology and Experimental Therapeutics. 324: 399-400; author repl. PMID 18094322 DOI: 10.1124/jpet.107.131557  1
2007 Santhakumar V, Wallner M, Otis TS. Ethanol acts directly on extrasynaptic subtypes of GABAA receptors to increase tonic inhibition. Alcohol (Fayetteville, N.Y.). 41: 211-21. PMID 17591544 DOI: 10.1016/j.alcohol.2007.04.011  1
2007 Kruger L, Otis TS. Whither withered Golgi? A retrospective evaluation of reticularist and synaptic constructs. Brain Research Bulletin. 72: 201-7. PMID 17452282 DOI: 10.1016/j.brainresbull.2006.11.016  1
2006 Breese GR, Criswell HE, Carta M, Dodson PD, Hanchar HJ, Khisti RT, Mameli M, Ming Z, Morrow AL, Olsen RW, Otis TS, Parsons LH, Penland SN, Roberto M, Siggins GR, et al. Basis of the gabamimetic profile of ethanol. Alcoholism, Clinical and Experimental Research. 30: 731-44. PMID 16573592 DOI: 10.1111/j.0145-6008.2006.00086.x  1
2006 Santhakumar V, Hanchar HJ, Wallner M, Olsen RW, Otis TS. Contributions of the GABAA receptor alpha6 subunit to phasic and tonic inhibition revealed by a naturally occurring polymorphism in the alpha6 gene. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 3357-64. PMID 16554486 DOI: 10.1523/JNEUROSCI.4799-05.2006  1
2006 Otis TS, Jen JC. Blessed are the pacemakers. Nature Neuroscience. 9: 297-8. PMID 16498419 DOI: 10.1038/nn0306-297  1
2005 Meera P, Dodson PD, Karakossian MH, Otis TS. Expression of GFP-tagged neuronal glutamate transporters in cerebellar Purkinje neurons. Neuropharmacology. 49: 883-9. PMID 16212990 DOI: 10.1016/j.neuropharm.2005.08.015  1
2005 Smith SL, Otis TS. Pattern-dependent, simultaneous plasticity differentially transforms the input-output relationship of a feedforward circuit. Proceedings of the National Academy of Sciences of the United States of America. 102: 14901-6. PMID 16199519 DOI: 10.1073/pnas.0505028102  1
2005 Valenzuela CF, Mameli M, Carta M. Single-amino-acid difference in the sequence of alpha6 subunit dramatically increases the ethanol sensitivity of recombinant GABAA receptors. Alcoholism, Clinical and Experimental Research. 29: 1356-7; author reply. PMID 16046882 DOI: 10.1097/01.ALC.0000171926.66397.94  1
2005 Hanchar HJ, Dodson PD, Olsen RW, Otis TS, Wallner M. Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity. Nature Neuroscience. 8: 339-45. PMID 15696164 DOI: 10.1038/nn1398  1
2004 Häusser M, Raman IM, Otis T, Smith SL, Nelson A, du Lac S, Loewenstein Y, Mahon S, Pennartz C, Cohen I, Yarom Y. The beat goes on: spontaneous firing in mammalian neuronal microcircuits. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 9215-9. PMID 15496653 DOI: 10.1523/JNEUROSCI.3375-04.2004  1
2004 Otis TS, Brasnjo G, Dzubay JA, Pratap M. Interactions between glutamate transporters and metabotropic glutamate receptors at excitatory synapses in the cerebellar cortex. Neurochemistry International. 45: 537-44. PMID 15186920 DOI: 10.1016/j.neuint.2003.11.007  1
2004 Karakossian MH, Otis TS. Excitation of cerebellar interneurons by group I metabotropic glutamate receptors. Journal of Neurophysiology. 92: 1558-65. PMID 15152021 DOI: 10.1152/jn.00300.2004  1
2004 Brasnjo G, Otis TS. Isolation of glutamate transport-coupled charge flux and estimation of glutamate uptake at the climbing fiber-Purkinje cell synapse. Proceedings of the National Academy of Sciences of the United States of America. 101: 6273-8. PMID 15067125 DOI: 10.1073/pnas.0308149101  1
2004 Smith SL, Judy JW, Otis TS. An ultra small array of electrodes for stimulating multiple inputs into a single neuron. Journal of Neuroscience Methods. 133: 109-14. PMID 14757351 DOI: 10.1016/j.jneumeth.2003.10.001  1
2003 Brasnjo G, Otis TS. Glycine transporters not only take out the garbage, they recycle. Neuron. 40: 667-9. PMID 14622571 DOI: 10.1016/S0896-6273(03)00725-6  1
2003 Smith SL, Otis TS. Persistent changes in spontaneous firing of Purkinje neurons triggered by the nitric oxide signaling cascade. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 367-72. PMID 12533595  1
2002 Dzubay JA, Otis TS. Climbing fiber activation of metabotropic glutamate receptors on cerebellar purkinje neurons. Neuron. 36: 1159-67. PMID 12495629 DOI: 10.1016/S0896-6273(02)01052-8  1
2002 Otis T. Helping thy neighbors: spillover at the mossy fiber glomerulus. Neuron. 35: 412-4. PMID 12165464 DOI: 10.1016/S0896-6273(02)00796-1  1
2001 Brasnjo G, Otis TS. Neuronal glutamate transporters control activation of postsynaptic metabotropic glutamate receptors and influence cerebellar long-term depression. Neuron. 31: 607-16. PMID 11545719 DOI: 10.1016/S0896-6273(01)00377-4  1
2001 Otis TS. Vesicular glutamate transporters in cognito. Neuron. 29: 11-4. PMID 11182077 DOI: 10.1016/S0896-6273(01)00176-3  1
2000 Otis TS, Kavanaugh MP. Isolation of current components and partial reaction cycles in the glial glutamate transporter EAAT2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 2749-57. PMID 10751425  1
1998 Otis TS, Jahr CE. Anion currents and predicted glutamate flux through a neuronal glutamate transporter. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 7099-110. PMID 9736633  1
1997 Otis TS, Kavanaugh MP, Jahr CE. Postsynaptic glutamate transport at the climbing fiber-Purkinje cell synapse. Science (New York, N.Y.). 277: 1515-8. PMID 9278516 DOI: 10.1126/science.277.5331.1515  1
1996 Otis TS, Trussell LO. Inhibition of transmitter release shortens the duration of the excitatory synaptic current at a calyceal synapse. Journal of Neurophysiology. 76: 3584-8. PMID 8930299  1
1996 Otis T, Zhang S, Trussell LO. Direct measurement of AMPA receptor desensitization induced by glutamatergic synaptic transmission. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 7496-504. PMID 8922405  1
1996 Otis TS, Wu YC, Trussell LO. Delayed clearance of transmitter and the role of glutamate transporters at synapses with multiple release sites. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 1634-44. PMID 8774432  1
1996 Buhl EH, Otis TS, Mody I. Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy model. Science (New York, N.Y.). 271: 369-73. PMID 8553076  1
1995 Mody I, Otis TS, Bragin A, Hsu M, Buzsáki G. GABAergic inhibition of granule cells and hilar neuronal synchrony following ischemia-induced hilar neuronal loss. Neuroscience. 69: 139-50. PMID 8637612 DOI: 10.1016/0306-4522(95)00190-T  1
1995 Otis TS, Raman IM, Trussell LO. AMPA receptors with high Ca2+ permeability mediate synaptic transmission in the avian auditory pathway. The Journal of Physiology. 482: 309-15. PMID 7714824  1
1994 Otis TS, De Koninck Y, Mody I. Lasting potentiation of inhibition is associated with an increased number of gamma-aminobutyric acid type A receptors activated during miniature inhibitory postsynaptic currents. Proceedings of the National Academy of Sciences of the United States of America. 91: 7698-702. PMID 8052645 DOI: 10.1073/pnas.91.16.7698  1
1994 Mody I, De Koninck Y, Otis TS, Soltesz I. Bridging the cleft at GABA synapses in the brain. Trends in Neurosciences. 17: 517-25. PMID 7532336 DOI: 10.1016/0166-2236(94)90155-4  1
1993 Otis TS, De Koninck Y, Mody I. Characterization of synaptically elicited GABAB responses using patch-clamp recordings in rat hippocampal slices. The Journal of Physiology. 463: 391-407. PMID 8246190 DOI: 10.1113/jphysiol.1993.sp019600  1
1992 Staley KJ, Otis TS, Mody I. Membrane properties of dentate gyrus granule cells: comparison of sharp microelectrode and whole-cell recordings. Journal of Neurophysiology. 67: 1346-58. PMID 1597717  1
1992 Otis TS, Mody I. Modulation of decay kinetics and frequency of GABAA receptor-mediated spontaneous inhibitory postsynaptic currents in hippocampal neurons. Neuroscience. 49: 13-32. PMID 1357584 DOI: 10.1016/0306-4522(92)90073-B  1
1992 Otis TS, Mody I. Differential activation of GABAA and GABAB receptors by spontaneously released transmitter. Journal of Neurophysiology. 67: 227-35. PMID 1348084  1
1992 Mody I, Otis TS, Staley KJ, Köhr G. The balance between excitation and inhibition in dentate granule cells and its role in epilepsy. Epilepsy Research. Supplement. 9: 331-9. PMID 1337447  1
1992 Mody I, Köhr G, Otis TS, Staley KJ. The electrophysiology of dentate gyrus granule cells in whole-cell recordings. Epilepsy Research. Supplement. 7: 159-68. PMID 1334661  1
1991 Otis TS, Staley KJ, Mody I. Perpetual inhibitory activity in mammalian brain slices generated by spontaneous GABA release. Brain Research. 545: 142-50. PMID 1650273 DOI: 10.1016/0006-8993(91)91280-E  1
1990 Otis TS, Gilly WF. Jet-propelled escape in the squid Loligo opalescens: concerted control by giant and non-giant motor axon pathways. Proceedings of the National Academy of Sciences of the United States of America. 87: 2911-5. PMID 2326255  1
Show low-probability matches.