Harald H. Sitte - Publications

Affiliations: 
Institute of Pharmacology Medical University of Vienna, Austria, Wien, Wien, Austria 

186 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Ilic M, Maier J, Holy M, Jaentsch K, Liechti ME, Lubec G, Baumann MH, Sitte HH, Luethi D. Corrigendum: Cell-Based Radiotracer Binding and Uptake Inhibition Assays: A Comparison of Methods to Assess the Potency of Drugs That Target Monoamine Transporters. Frontiers in Pharmacology. 13: 878641. PMID 35370673 DOI: 10.3389/fphar.2022.878641  0.318
2022 Gradisch R, Szöllősi D, Niello M, Lazzarin E, Sitte HH, Stockner T. Occlusion of the human serotonin transporter is mediated by serotonin-induced conformational changes in the bundle domain. The Journal of Biological Chemistry. 298: 101613. PMID 35065961 DOI: 10.1016/j.jbc.2022.101613  0.369
2021 Angenoorth TJF, Stankovic S, Niello M, Holy M, Brandt SD, Sitte HH, Maier J. Interaction Profiles of Central Nervous System Active Drugs at Human Organic Cation Transporters 1-3 and Human Plasma Membrane Monoamine Transporter. International Journal of Molecular Sciences. 22. PMID 34884800 DOI: 10.3390/ijms222312995  0.43
2021 Rudin D, McCorvy JD, Glatfelter GC, Luethi D, Szöllősi D, Ljubišić T, Kavanagh PV, Dowling G, Holy M, Jaentsch K, Walther D, Brandt SD, Stockner T, Baumann MH, Halberstadt AL, ... Sitte HH, et al. (2-Aminopropyl)benzo[β]thiophenes (APBTs) are novel monoamine transporter ligands that lack stimulant effects but display psychedelic-like activity in mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 34750565 DOI: 10.1038/s41386-021-01221-0  0.356
2021 Camacho-Hernandez GA, Casiraghi A, Rudin D, Luethi D, Ku TC, Guthrie DA, Straniero V, Valoti E, Schütz GJ, Sitte HH, Newman AH. Illuminating the norepinephrine transporter: fluorescent probes based on nisoxetine and talopram. Rsc Medicinal Chemistry. 12: 1174-1186. PMID 34355183 DOI: 10.1039/d1md00072a  0.353
2021 Gether U, Sitte HH. It takes two-or more-to tango: Revisiting the role of dopamine transporter oligomerization. The Journal of Biological Chemistry. 296: 100629. PMID 34237901 DOI: 10.1016/j.jbc.2021.100629  0.428
2021 Bhat S, Niello M, Schicker K, Pifl C, Sitte HH, Freissmuth M, Sandtner W. Handling of intracellular K determines voltage dependence of plasmalemmal monoamine transporter function. Elife. 10. PMID 34061030 DOI: 10.7554/eLife.67996  0.341
2021 Saha K, Yang JW, Hofmaier T, Venkatesan S, Steinkellner T, Kudlacek O, Sucic S, Freissmuth M, Sitte HH. Constitutive Endocytosis of the Neuronal Glutamate Transporter Excitatory Amino Acid Transporter-3 Requires ARFGAP1. Frontiers in Physiology. 12: 671034. PMID 34040545 DOI: 10.3389/fphys.2021.671034  0.336
2021 Niello M, Cintulová D, Raithmayr P, Holy M, Jäntsch K, Colas C, Ecker GF, Sitte HH, Mihovilovic MD. Effects of Hydroxylated Mephedrone Metabolites on Monoamine Transporter Activity . Frontiers in Pharmacology. 12: 654061. PMID 33897439 DOI: 10.3389/fphar.2021.654061  0.35
2021 Maier J, Rauter L, Rudin D, Niello M, Holy M, Schmid D, Wilson J, Blough BE, Gannon BM, Murnane KS, Sitte HH. α-PPP and its derivatives are selective partial releasers at the human norepinephrine transporter A pharmacological characterization of interactions between pyrrolidinopropiophenones and high and low affinity monoamine transporters. Neuropharmacology. 108570. PMID 33864800 DOI: 10.1016/j.neuropharm.2021.108570  0.343
2020 Hall JL, Sohail A, Cabrita EJ, Macdonald C, Stockner T, Sitte HH, Angulo J, MacMillan F. Saturation transfer difference NMR on the integral trimeric membrane transport protein GltPh determines cooperative substrate binding. Scientific Reports. 10: 16483. PMID 33020522 DOI: 10.1038/s41598-020-73443-z  0.367
2020 Jayaraman K, Das AK, Luethi D, Szöllősi D, Schütz GJ, Reith ME, Sitte HH, Stockner T. SLC6 transporter oligomerization. Journal of Neurochemistry. PMID 32767560 DOI: 10.1111/Jnc.15145  0.516
2020 Zhu R, Sandtner W, Ahiable JEA, Newman AH, Freissmuth M, Sitte HH, Hinterdorfer P. Allosterically Linked Binding Sites in Serotonin Transporter Revealed by Single Molecule Force Spectroscopy. Frontiers in Molecular Biosciences. 7: 99. PMID 32656227 DOI: 10.3389/Fmolb.2020.00099  0.375
2020 Ilic M, Holy M, Jaentsch K, Liechti ME, Lubec G, Baumann MH, Sitte HH, Luethi D. Cell-Based Radiotracer Binding and Uptake Inhibition Assays: A Comparison of Methods to Assess the Potency of Drugs That Target Monoamine Transporters. Frontiers in Pharmacology. 11: 673. PMID 32508638 DOI: 10.3389/Fphar.2020.00673  0.461
2020 Niello M, Gradisch R, Loland CJ, Stockner T, Sitte HH. Allosteric Modulation of Neurotransmitter Transporters as a Therapeutic Strategy. Trends in Pharmacological Sciences. 41: 446-463. PMID 32471654 DOI: 10.1016/J.Tips.2020.04.006  0.388
2020 Nasim F, Schmid D, Szakács G, Sohail A, Sitte HH, Chiba P, Stockner T. Active transport of rhodamine 123 by the human multidrug transporter P-glycoprotein involves two independent outer gates. Pharmacology Research & Perspectives. 8: e00572. PMID 32232949 DOI: 10.1002/Prp2.572  0.466
2020 Fagan RR, Kearney PJ, Sweeney CG, Luethi D, Schoot Uiterkamp FE, Schicker K, Alejandro BS, O'Connor LC, Sitte HH, Melikian HE. Dopamine transporter trafficking and Rit2 GTPase: Mechanism of action and in vivo impact. The Journal of Biological Chemistry. PMID 32132171 DOI: 10.1074/Jbc.Ra120.012628  0.418
2020 Weidenauer A, Bauer M, Sauerzopf U, Bartova L, Nics L, Pfaff S, Philippe C, Berroterán-Infante N, Pichler V, Meyer BM, Rabl U, Sezen P, Cumming P, Stimpfl T, Sitte HH, et al. On the relationship of first-episode psychosis to the amphetamine-sensitized state: a dopamine D receptor agonist radioligand study. Translational Psychiatry. 10: 2. PMID 32066718 DOI: 10.1038/S41398-019-0681-5  0.351
2020 Pifl C, Sitte HH. A Tribute to Oleh Hornykiewicz (1926–2020) Trends in Pharmacological Sciences. 41: 499-501. DOI: 10.1016/J.Tips.2020.06.004  0.319
2020 Zhu R, Gobl J, Holy M, Kudlacek O, Sandtner W, Stockner T, Gruber HJ, Freissmuth M, Hauck Newman A, Sitte HH, Hinterdorfer P. Two Distinct Ligand Binding Sites in Monoamine Transporters Monitored by Nanopharmacological Force Sensing Biophysical Journal. 118: 618a-619a. DOI: 10.1016/J.Bpj.2019.11.3337  0.399
2019 Khan JA, Sohail A, Jayaraman K, Szöllősi D, Sandtner W, Sitte HH, Stockner T. The Amino Terminus of LeuT Changes Conformation in an Environment Sensitive Manner. Neurochemical Research. PMID 31858375 DOI: 10.1007/S11064-019-02928-9  0.405
2019 Kalaba P, Ilić M, Aher NY, Dragačević V, Wieder M, Zehl M, Wackerlig J, Beyl S, Sartori SB, Ebner K, Roller A, Lukic N, Beryozkina TV, González ERP, Neill PJ, ... ... Sitte HH, et al. Structure Activity Relationships of Novel Thiazole-Based Modafinil Analogues Acting at Monoamine Transporters. Journal of Medicinal Chemistry. PMID 31841637 DOI: 10.1021/Acs.Jmedchem.9B01938  0.405
2019 Niello M, Cintulova D, Hellsberg E, Jäntsch K, Holy M, Ayatollahi LH, Cozzi NV, Freissmuth M, Sandtner W, Ecker GF, Mihovilovic MD, Sitte HH. para-Trifluoromethyl-methcathinone is an allosteric modulator of the serotonin transporter. Neuropharmacology. PMID 31028773 DOI: 10.1016/J.Neuropharm.2019.04.021  0.493
2019 Campbell NG, Shekar A, Aguilar JI, Peng D, Navratna V, Yang D, Morley AN, Duran AM, Galli G, O'Grady B, Ramachandran R, Sutcliffe JS, Sitte HH, Erreger K, Meiler J, et al. Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion in . Proceedings of the National Academy of Sciences of the United States of America. PMID 30755521 DOI: 10.1073/Pnas.1816247116  0.441
2019 Das AK, Kudlacek O, Baumgart F, Jaentsch K, Stockner T, Sitte HH, Schütz GJ. Dopamine transporter forms stable dimers in the live cell plasma membrane in a phosphatidylinositol-4,5-bisphosphate independent manner. The Journal of Biological Chemistry. PMID 30705091 DOI: 10.1074/Jbc.Ra118.006178  0.518
2019 Mayer FP, Cintulova D, Pittrich DA, Wimmer L, Luethi D, Holy M, Jaentsch K, Tischberger S, Gmeiner G, Hoener MC, Liechti ME, Mihovilovic MD, Sitte HH. Stereochemistry of phase-1 metabolites of mephedrone determines their effectiveness as releasers at the serotonin transporter. Neuropharmacology. PMID 30610839 DOI: 10.1016/J.Neuropharm.2018.12.032  0.474
2018 Yang JW, Larson G, Konrad L, Shetty M, Holy M, Jäntsch K, Kastein M, Heo S, Erdem FA, Lubec G, Vaughan RA, Sitte HH, Foster JD. Dephosphorylation of human dopamine transporter at threonine 48 by protein phosphatase PP1/2A upregulates transport velocity. The Journal of Biological Chemistry. PMID 30587577 DOI: 10.1074/Jbc.Ra118.005251  0.432
2018 Fraser-Spears R, Krause-Heuer AM, Basiouny M, Mayer FP, Manishimwe R, Wyatt NA, Dobrowolski JC, Roberts MP, Greguric I, Kumar N, Koek W, Sitte HH, Callaghan PD, Fraser BH, Daws LC. Comparative analysis of novel decynium-22 analogs to inhibit transport by the low-affinity, high-capacity monoamine transporters, organic cation transporters 2 and 3, and plasma membrane monoamine transporter. European Journal of Pharmacology. 842: 351-364. PMID 30473490 DOI: 10.1016/J.Ejphar.2018.10.028  0.521
2018 Baumann MH, Walters HM, Niello M, Sitte HH. Neuropharmacology of Synthetic Cathinones. Handbook of Experimental Pharmacology. PMID 30406443 DOI: 10.1007/164_2018_178  0.484
2018 Saha K, Li Y, Holy M, Lehner KR, Bukhari MO, Partilla JS, Sandtner W, Sitte HH, Baumann MH. The synthetic cathinones, butylone and pentylone, are stimulants that act as dopamine transporter blockers but 5-HT transporter substrates. Psychopharmacology. PMID 30345459 DOI: 10.1007/S00213-018-5075-5  0.456
2018 Mayer FP, Schmid D, Holy M, Daws LC, Sitte HH. "Polytox" synthetic cathinone abuse: A potential role for organic cation transporter 3 in combined cathinone-induced efflux. Neurochemistry International. PMID 30248432 DOI: 10.1016/J.Neuint.2018.09.008  0.538
2018 Maier J, Mayer FP, Luethi D, Holy M, Jäntsch K, Reither H, Hirtler L, Hoener MC, Liechti ME, Pifl C, Brandt SD, Sitte HH. The psychostimulant (±)-cis-4,4'-dimethylaminorex (4,4'-DMAR) interacts with human plasmalemmal and vesicular monoamine transporters. Neuropharmacology. PMID 29908239 DOI: 10.1016/J.Neuropharm.2018.06.018  0.522
2018 Jayaraman K, Morley AN, Szöllősi D, Wassenaar TA, Sitte HH, Stockner T. Dopamine transporter oligomerization involves the scaffold domain, but spares the bundle domain. Plos Computational Biology. 14: e1006229. PMID 29874235 DOI: 10.1371/Journal.Pcbi.1006229  0.5
2018 Mayer FP, Schmid D, Owens WA, Gould GG, Apuschkin M, Kudlacek O, Salzer I, Boehm S, Chiba P, Williams PH, Wu HH, Gether U, Koek W, Daws LC, Sitte HH. An unsuspected role for organic cation transporter 3 in the actions of amphetamine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29773909 DOI: 10.1038/S41386-018-0053-5  0.49
2018 Reisinger SN, Kong E, Molz B, Humberg T, Sideromenos S, Cicvaric A, Steinkellner T, Yang JW, Cabatic M, Monje FJ, Sitte HH, Nichols BJ, Pollak DD. Flotillin-1 interacts with the serotonin transporter and modulates chronic corticosterone response. Genes, Brain, and Behavior. e12482. PMID 29667320 DOI: 10.1111/Gbb.12482  0.429
2018 Hasenhuetl PS, Bhat S, Mayer FP, Sitte HH, Freissmuth M, Sandtner W. A kinetic account for amphetamine-induced monoamine release. The Journal of General Physiology. PMID 29439119 DOI: 10.1085/Jgp.201711915  0.471
2018 Kristofova M, Aher YD, Ilic M, Radoman B, Kalaba P, Dragacevic V, Aher NY, Leban J, Korz V, Zanon L, Neuhaus W, Wieder M, Langer T, Urban E, Sitte HH, et al. A daily single dose of a novel modafinil analogue CE-123 improves memory acquisition and memory retrieval. Behavioural Brain Research. 343: 83-94. PMID 29410048 DOI: 10.1016/J.Bbr.2018.01.032  0.38
2018 Sitte H, Willeit M. Introduction to the Special Issue on dopamine celebrating the 90th birthday of Oleh Hornykiewicz. The European Journal of Neuroscience. 45: 1. PMID 28044407 DOI: 10.1111/Ejn.13502  0.314
2017 Kalaba P, Aher NY, Ilić M, Dragačević V, Wieder M, Miklosi AG, Zehl M, Wackerlig J, Roller A, Beryozkina TV, Radoman B, Saroja SR, Lindner W, Gonzalez EP, Bakulev VA, ... ... Sitte HH, et al. Heterocyclic Analogues of Modafinil as Novel, Atypical Dopamine Transporter Inhibitors. Journal of Medicinal Chemistry. PMID 29091428 DOI: 10.1021/Acs.Jmedchem.7B01313  0.492
2017 Mayer FP, Burchardt NV, Decker AM, Partilla JS, Li Y, McLaughlin G, Kavanagh PV, Sandtner W, Blough BE, Brandt SD, Baumann MH, Sitte HH. Fluorinated phenmetrazine "legal highs" act as substrates for high-affinity monoamine transporters of the SLC6 family. Neuropharmacology. PMID 28988906 DOI: 10.1016/J.Neuropharm.2017.10.006  0.515
2017 Li Y, Mayer FP, Hasenhuetl PS, Burtscher V, Schicker K, Sitte HH, Freissmuth M, Sandtner W. Occupancy of the zinc-binding site by transition metals decreases the substrate affinity of the human dopamine transporter by an allosteric mechanism. The Journal of Biological Chemistry. 292: 7161. PMID 28455408 DOI: 10.1074/jbc.A116.760140  0.337
2017 Anderluh A, Hofmaier T, Klotzsch E, Kudlacek O, Stockner T, Sitte HH, Schütz GJ. Direct PIP2 binding mediates stable oligomer formation of the serotonin transporter. Nature Communications. 8: 14089. PMID 28102201 DOI: 10.1038/Ncomms14089  0.469
2017 Li Y, Mayer FP, Hasenhuetl PS, Burtscher V, Schicker K, Sitte HH, Freissmuth M, Sandtner W. Occupancy of the Zinc Binding-site by Transition Metals decreases the Substrate Affinity of the Human Dopamine Transporter by an Allosteric Mechanism. The Journal of Biological Chemistry. PMID 28096460 DOI: 10.1074/Jbc.M116.760140  0.439
2017 Jayaraman K, Sitte HH, Stockner T. Oligomerization of Human Dopamine Transporter (hDAT) Biophysical Journal. 112: 127a. DOI: 10.1016/J.Bpj.2016.11.708  0.532
2016 Mayer FP, Luf A, Nagy C, Holy M, Schmid R, Freissmuth M, Sitte HH. Application of a Combined Approach to Identify New Psychoactive Street Drugs and Decipher Their Mechanisms at Monoamine Transporters. Current Topics in Behavioral Neurosciences. PMID 28025810 DOI: 10.1007/7854_2016_63  0.355
2016 Sweeney CG, Tremblay BP, Stockner T, Sitte HH, Melikian HE. Dopamine Transporter Amino- and Carboxy-Termini Synergistically Contribute to Substrate and Inhibitor Affinities. The Journal of Biological Chemistry. PMID 27986813 DOI: 10.1074/Jbc.M116.762872  0.528
2016 Seddik A, Geerke DP, Stockner T, Holy M, Kudlacek O, Cozzi NV, Ruoho AE, Sitte HH, Ecker GF. Combined Simulation and Mutation Studies to Elucidate Selectivity of Unsubstituted Amphetamine-like Cathinones at the Dopamine Transporter. Molecular Informatics. PMID 27860344 DOI: 10.1002/Minf.201600094  0.512
2016 Sohail A, Jayaraman K, Venkatesan S, Gotfryd K, Daerr M, Gether U, Loland CJ, Wanner KT, Freissmuth M, Sitte HH, Sandtner W, Stockner T. The Environment Shapes the Inner Vestibule of LeuT. Plos Computational Biology. 12: e1005197. PMID 27835643 DOI: 10.1371/Journal.Pcbi.1005197  0.356
2016 Sitte HH, Pifl C, Rajput AH, Hörtnagl H, Tong J, Lloyd GK, Kish SJ, Hornykiewicz O. Dopamine and noradrenaline, but not serotonin, in the human claustrum are greatly reduced in patients with Parkinson's disease: Possible functional implications. The European Journal of Neuroscience. PMID 27741357 DOI: 10.1111/Ejn.13435  0.323
2016 Billesbølle CB, Mortensen JS, Sohail A, Schmidt SG, Shi L, Sitte HH, Gether U, Loland CJ. Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter. Nature Communications. 7: 12755. PMID 27678200 DOI: 10.1038/Ncomms12755  0.398
2016 Mayer FP, Wimmer L, Dillon-Carter O, Partilla JS, Burchardt N, Mihovilovic MD, Baumann MH, Sitte HH. Phase I metabolites of mephedrone display biological activity as substrates at monoamine transporters. British Journal of Pharmacology. PMID 27391165 DOI: 10.1111/Bph.13547  0.436
2016 Aher YD, Subramaniyan S, Shanmugasundaram B, Sase A, Saroja SR, Holy M, Höger H, Beryozkina T, Sitte HH, Leban JJ, Lubec G. A Novel Heterocyclic Compound CE-104 Enhances Spatial Working Memory in the Radial Arm Maze in Rats and Modulates the Dopaminergic System. Frontiers in Behavioral Neuroscience. 10: 20. PMID 26941626 DOI: 10.3389/Fnbeh.2016.00020  0.441
2016 Sase A, Aher YD, Saroja SR, Ganesan MK, Sase S, Holy M, Höger H, Bakulev V, Ecker GF, Langer T, Sitte HH, Leban J, Lubec G. A heterocyclic compound CE-103 inhibits dopamine reuptake and modulates dopamine transporter and dopamine D1-D3 containing receptor complexes. Neuropharmacology. 102: 186-96. PMID 26407764 DOI: 10.1016/J.Neuropharm.2015.07.039  0.433
2016 Bakulev V, Lubec G, Beryozkina T, Dianova L, Berseneva V, Slepukhin P, Leban J, Kalaba P, Aher N, Ilic M, Sitte H. Design and Synthesis of N-Sulfonylamidines of Modafinic Acid Synthesis. 48: 1046-1054. DOI: 10.1055/S-0035-1561350  0.387
2016 Hasenhuetl PS, Freissmuth M, Sitte HH, Schicker K, Li Y, Sandtner W. Dissecting the Catalytic Cycle of the Serotonin Transporter Biophysical Journal. 110: 179a. DOI: 10.1016/J.Bpj.2015.11.999  0.543
2016 Anderluh A, Hofmaier T, Klotzsch E, Kudlacek O, Stockner T, Sitte HH, Schütz GJ. Lipid Mediated Oligomeric Assembly of the Serotonin Transporter at the Plasma Membrane Biophysical Journal. 110: 216a. DOI: 10.1016/J.Bpj.2015.11.1199  0.368
2016 Zhu R, Heilinger A, Newman AH, Freissmuth M, Sitte HH, Hinterdorfer P. Nanopharmacological Force Sensing Reveals Two Ligand Binding Sites in Monoamine Transporters Biophysical Journal. 110: 9a. DOI: 10.1016/J.Bpj.2015.11.104  0.415
2015 Zhu R, Sinwel D, Hasenhuetl PS, Saha K, Kumar V, Zhang P, Rankl C, Holy M, Sucic S, Kudlacek O, Karner A, Sandtner W, Stockner T, Gruber HJ, Freissmuth M, ... ... Sitte HH, et al. Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding Sites. Angewandte Chemie (International Ed. in English). PMID 26695726 DOI: 10.1002/Anie.201508755  0.385
2015 Sandtner W, Stockner T, Hasenhuetl PS, Partilla JS, Seddik A, Zhang Y, Cao J, Holy M, Steinkellner T, Rudnick G, Baumann MH, Ecker GF, Newman AH, Sitte HH. Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine Transporters. Molecular Pharmacology. PMID 26519222 DOI: 10.1124/Mol.115.101394  0.45
2015 Li Y, Hasenhuetl PS, Schicker K, Sitte HH, Freissmuth M, Sandtner W. Dual Action of Zn2+ on the Transport Cycle of the Dopamine Transporter. The Journal of Biological Chemistry. 290: 31069-76. PMID 26504078 DOI: 10.1074/Jbc.M115.688275  0.514
2015 Venkatesan S, Saha K, Sohail A, Sandtner W, Freissmuth M, Ecker GF, Sitte HH, Stockner T. Refinement of the Central Steps of Substrate Transport by the Aspartate Transporter GltPh: Elucidating the Role of the Na2 Sodium Binding Site. Plos Computational Biology. 11: e1004551. PMID 26485255 DOI: 10.1371/Journal.Pcbi.1004551  0.514
2015 Karabacak Y, Sase S, Aher YD, Sase A, Saroja SR, Cicvaric A, Höger H, Berger M, Bakulev V, Sitte HH, Leban J, Monje FJ, Lubec G. The effect of modafinil on the rat dopamine transporter and dopamine receptors D1-D3 paralleling cognitive enhancement in the radial arm maze. Frontiers in Behavioral Neuroscience. 9: 215. PMID 26347626 DOI: 10.3389/Fnbeh.2015.00215  0.378
2015 Steinkellner T, Montgomery TR, Hofmaier T, Kudlacek O, Yang JW, Rickhag M, Jung G, Lubec G, Gether U, Freissmuth M, Sitte HH. Amphetamine action at the cocaine- and antidepressant-sensitive serotonin transporter is modulated by αCaMKII. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 8258-71. PMID 26019340 DOI: 10.1523/Jneurosci.4034-14.2015  0.532
2015 Hasenhuetl PS, Schicker K, Koenig X, Li Y, Sarker S, Stockner T, Sucic S, Sitte HH, Freissmuth M, Sandtner W. Ligand Selectivity among the Dopamine and Serotonin Transporters Specified by the Forward Binding Reaction. Molecular Pharmacology. 88: 12-8. PMID 25873594 DOI: 10.1124/Mol.115.099036  0.761
2015 Koban F, El-Kasaby A, Häusler C, Stockner T, Simbrunner BM, Sitte HH, Freissmuth M, Sucic S. A salt bridge linking the first intracellular loop with the C terminus facilitates the folding of the serotonin transporter. The Journal of Biological Chemistry. 290: 13263-78. PMID 25869136 DOI: 10.1074/Jbc.M115.641357  0.388
2015 Sitte HH, Schütz GJ, Freissmuth M. Cooperativity between individual transporter protomers: new data fuelling old complexes. Journal of Neurochemistry. 133: 163-6. PMID 25772534 DOI: 10.1111/Jnc.13086  0.518
2015 Jurik A, Zdrazil B, Holy M, Stockner T, Sitte HH, Ecker GF. A binding mode hypothesis of tiagabine confirms liothyronine effect on γ-aminobutyric acid transporter 1 (GAT1). Journal of Medicinal Chemistry. 58: 2149-58. PMID 25679268 DOI: 10.1021/Jm5015428  0.461
2015 Sitte HH, Freissmuth M. Amphetamines, new psychoactive drugs and the monoamine transporter cycle. Trends in Pharmacological Sciences. 36: 41-50. PMID 25542076 DOI: 10.1016/J.Tips.2014.11.006  0.515
2015 Saha K, Partilla JS, Lehner KR, Seddik A, Stockner T, Holy M, Sandtner W, Ecker GF, Sitte HH, Baumann MH. 'Second-generation' mephedrone analogs, 4-MEC and 4-MePPP, differentially affect monoamine transporter function. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1321-31. PMID 25502630 DOI: 10.1038/Npp.2014.325  0.54
2015 Schmid D, Koenig X, Bulusu S, Schicker K, Freissmuth M, Sitte HH, Sandtner W. The conservative view: Is it necessary to implant a stent into the dopamine transporter? British Journal of Pharmacology. 172: 4775-4778. PMID 24824446 DOI: 10.1111/Bph.12766  0.476
2015 Steinkellner T, Montgomery TR, Hofmaier T, Kudlacek O, Yang JW, Rickhag M, Jung G, Lubec G, Gether U, Freissmuth M, Sitte HH. Amphetamine action at the cocaine- and antidepressantsensitive serotonin transporter is modulated by αCaMKII Journal of Neuroscience. 35: 8258-8271. DOI: 10.1523/JNEUROSCI.4034-14.2015  0.34
2015 Hasenhuetl PS, Freissmuth M, Sitte HH, Sandtner W. A Kinetic Assessment of Ligand Binding to Monoamine-Transporters Biophysical Journal. 108: 463a. DOI: 10.1016/J.Bpj.2014.11.2524  0.458
2015 Jayaraman K, Sohail A, Venkatesan S, Santdner W, Sitte H, Stockner T. The Environment Modulates the Conformation of Transmembrane Helix 1A in the Leucine Transporter (LEUT) Biophysical Journal. 108: 461a-462a. DOI: 10.1016/J.Bpj.2014.11.2518  0.453
2015 Sitte HH, Venkatesan S, Sohail A, Saha K, Jayaraman K, Ecker GF, Freissmuth M, Sandtner W, Stockner T. Transporters in Motion: Combining Computational Approaches and LRET-Measurements Biophysical Journal. 108: 199a. DOI: 10.1016/J.Bpj.2014.11.1101  0.511
2014 El-Kasaby A, Koban F, Sitte HH, Freissmuth M, Sucic S. A cytosolic relay of heat shock proteins HSP70-1A and HSP90β monitors the folding trajectory of the serotonin transporter. The Journal of Biological Chemistry. 289: 28987-9000. PMID 25202009 DOI: 10.1074/Jbc.M114.595090  0.377
2014 Kivell B, Uzelac Z, Sundaramurthy S, Rajamanickam J, Ewald A, Chefer V, Jaligam V, Bolan E, Simonson B, Annamalai B, Mannangatti P, Prisinzano TE, Gomes I, Devi LA, Jayanthi LD, ... Sitte HH, et al. Salvinorin A regulates dopamine transporter function via a kappa opioid receptor and ERK1/2-dependent mechanism. Neuropharmacology. 86: 228-40. PMID 25107591 DOI: 10.1016/J.Neuropharm.2014.07.016  0.496
2014 Fenollar-Ferrer C, Stockner T, Schwarz TC, Pal A, Gotovina J, Hofmaier T, Jayaraman K, Adhikary S, Kudlacek O, Mehdipour AR, Tavoulari S, Rudnick G, Singh SK, Konrat R, Sitte HH, et al. Structure and regulatory interactions of the cytoplasmic terminal domains of serotonin transporter. Biochemistry. 53: 5444-60. PMID 25093911 DOI: 10.1021/Bi500637F  0.432
2014 Michl J, Scharinger C, Zauner M, Kasper S, Freissmuth M, Sitte HH, Ecker GF, Pezawas L. A multivariate approach linking reported side effects of clinical antidepressant and antipsychotic trials to in vitro binding affinities. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 24: 1463-74. PMID 25044049 DOI: 10.1016/J.Euroneuro.2014.06.013  0.329
2014 Hansen FH, Skjørringe T, Yasmeen S, Arends NV, Sahai MA, Erreger K, Andreassen TF, Holy M, Hamilton PJ, Neergheen V, Karlsborg M, Newman AH, Pope S, Heales SJ, Friberg L, ... ... Sitte HH, et al. Missense dopamine transporter mutations associate with adult parkinsonism and ADHD. The Journal of Clinical Investigation. 124: 3107-20. PMID 24911152 DOI: 10.1172/Jci73778  0.414
2014 Hamilton PJ, Belovich AN, Khelashvili G, Saunders C, Erreger K, Javitch JA, Sitte HH, Weinstein H, Matthies HJ, Galli A. PIP2 regulates psychostimulant behaviors through its interaction with a membrane protein. Nature Chemical Biology. 10: 582-9. PMID 24880859 DOI: 10.1038/Nchembio.1545  0.454
2014 Steinkellner T, Mus L, Eisenrauch B, Constantinescu A, Leo D, Konrad L, Rickhag M, Sørensen G, Efimova EV, Kong E, Willeit M, Sotnikova TD, Kudlacek O, Gether U, Freissmuth M, ... ... Sitte HH, et al. In vivo amphetamine action is contingent on αCaMKII. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 2681-93. PMID 24871545 DOI: 10.1038/Npp.2014.124  0.496
2014 Anderluh A, Klotzsch E, Ries J, Reismann AW, Weber S, Fölser M, Koban F, Freissmuth M, Sitte HH, Schütz GJ. Tracking single serotonin transporter molecules at the endoplasmic reticulum and plasma membrane. Biophysical Journal. 106: L33-5. PMID 24806941 DOI: 10.1016/J.Bpj.2014.03.019  0.338
2014 Montgomery TR, Steinkellner T, Sucic S, Koban F, Schüchner S, Ogris E, Sitte HH, Freissmuth M. Axonal targeting of the serotonin transporter in cultured rat dorsal raphe neurons is specified by SEC24C-dependent export from the endoplasmic reticulum. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 6344-51. PMID 24790205 DOI: 10.1523/Jneurosci.2991-13.2014  0.387
2014 Scharinger C, Rabl U, Kasess CH, Meyer BM, Hofmaier T, Diers K, Bartova L, Pail G, Huf W, Uzelac Z, Hartinger B, Kalcher K, Perkmann T, Haslacher H, Meyer-Lindenberg A, ... ... Sitte HH, et al. Platelet serotonin transporter function predicts default-mode network activity. Plos One. 9: e92543. PMID 24667541 DOI: 10.1371/Journal.Pone.0092543  0.346
2014 Anderluh A, Klotzsch E, Reismann AW, Brameshuber M, Kudlacek O, Newman AH, Sitte HH, Schütz GJ. Single molecule analysis reveals coexistence of stable serotonin transporter monomers and oligomers in the live cell plasma membrane. The Journal of Biological Chemistry. 289: 4387-94. PMID 24394416 DOI: 10.1074/Jbc.M113.531632  0.406
2014 Cakil YD, Khunweeraphong N, Parveen Z, Schmid D, Artaker M, Ecker GF, Sitte HH, Pusch O, Stockner T, Chiba P. Pore-exposed tyrosine residues of p-glycoprotein are important hydrogen-bonding partners for drugs Molecular Pharmacology. 85: 420-428. PMID 24366667 DOI: 10.1124/Mol.113.088526  0.433
2014 Hofmaier T, Luf A, Seddik A, Stockner T, Holy M, Freissmuth M, Ecker GF, Schmid R, Sitte HH, Kudlacek O. Aminorex, a metabolite of the cocaine adulterant levamisole, exerts amphetamine like actions at monoamine transporters. Neurochemistry International. 73: 32-41. PMID 24296074 DOI: 10.1016/J.Neuint.2013.11.010  0.462
2014 Felts B, Pramod AB, Sandtner W, Burbach N, Bulling S, Sitte HH, Henry LK. The two Na+ sites in the human serotonin transporter play distinct roles in the ion coupling and electrogenicity of transport. The Journal of Biological Chemistry. 289: 1825-40. PMID 24293367 DOI: 10.1074/Jbc.M113.504654  0.505
2014 Baumann MH, Bulling S, Benaderet TS, Saha K, Ayestas MA, Partilla JS, Ali SF, Stockner T, Rothman RB, Sandtner W, Sitte HH. Evidence for a role of transporter-mediated currents in the depletion of brain serotonin induced by serotonin transporter substrates. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 1355-65. PMID 24287719 DOI: 10.1038/Npp.2013.331  0.416
2014 Sandtner W, Schmid D, Schicker K, Gerstbrein K, Koenig X, Mayer FP, Boehm S, Freissmuth M, Sitte HH. A quantitative model of amphetamine action on the 5-HT transporter. British Journal of Pharmacology. 171: 1007-18. PMID 24251585 DOI: 10.1111/Bph.12520  0.517
2014 Venkatesan S, Sohail A, Saha K, Ecker G, Stockner T, Sandtner W, Sitte H. The Aspartate Transporter in Motion - Combining Steered Molecular Dynamics with Lanthanide Resonance Energy Transfer based Distance Measurements Biophysical Journal. 106: 366a. DOI: 10.1016/J.Bpj.2013.11.2077  0.455
2014 Sandtner W, Schmid D, Schicker K, Freissmuth M, Sitte HH. A Quantitative Model of Amphetamine Action on the Serotonin Transporter Biophysical Journal. 106: 365a. DOI: 10.1016/J.Bpj.2013.11.2069  0.489
2014 Sohail A, Kudlacek O, Daerr M, Stolt-Bergner P, Ecker G, Freissmuth M, Wanner K, Stockner T, Sandtner W, Sitte H. Unfolding the Structure of LeuT Employing Luminescence Resonance Energy Transfer Biophysical Journal. 106: 258a. DOI: 10.1016/J.Bpj.2013.11.1515  0.45
2013 Seddik A, Holy M, Weissensteiner R, Zdrazil B, Sitte HH, Ecker GF. Probing the Selectivity of Monoamine Transporter Substrates by Means of Molecular Modeling. Molecular Informatics. 32: 409-413. PMID 23956802 DOI: 10.1002/Minf.201300013  0.501
2013 Rickhag M, Owens WA, Winkler MT, Strandfelt KN, Rathje M, Sørensen G, Andresen B, Madsen KL, Jørgensen TN, Wörtwein G, Woldbye DP, Sitte H, Daws LC, Gether U. Membrane-permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release. The Journal of Biological Chemistry. 288: 27534-44. PMID 23884410 DOI: 10.1074/Jbc.M112.441295  0.48
2013 Buchmayer F, Schicker K, Steinkellner T, Geier P, Stübiger G, Hamilton PJ, Jurik A, Stockner T, Yang JW, Montgomery T, Holy M, Hofmaier T, Kudlacek O, Matthies HJ, Ecker GF, ... ... Sitte HH, et al. Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphate. Proceedings of the National Academy of Sciences of the United States of America. 110: 11642-7. PMID 23798435 DOI: 10.1073/Pnas.1220552110  0.554
2013 Stockner T, Montgomery TR, Kudlacek O, Weissensteiner R, Ecker GF, Freissmuth M, Sitte HH. Mutational analysis of the high-affinity zinc binding site validates a refined human dopamine transporter homology model. Plos Computational Biology. 9: e1002909. PMID 23436987 DOI: 10.1371/Journal.Pcbi.1002909  0.497
2013 Rosenauer R, Luf A, Holy M, Freissmuth M, Schmid R, Sitte HH. A combined approach using transporter-flux assays and mass spectrometry to examine psychostimulant street drugs of unknown content. Acs Chemical Neuroscience. 4: 182-90. PMID 23336057 DOI: 10.1021/Cn3001763  0.38
2013 Sucic S, Koban F, El-Kasaby A, Kudlacek O, Stockner T, Sitte HH, Freissmuth M. Switching the clientele: a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24C. The Journal of Biological Chemistry. 288: 5330-41. PMID 23288844 DOI: 10.1074/Jbc.M112.408237  0.542
2013 Cozzi NV, Brandt SD, Daley PF, Partilla JS, Rothman RB, Tulzer A, Sitte HH, Baumann MH. Pharmacological examination of trifluoromethyl ring-substituted methcathinone analogs. European Journal of Pharmacology. 699: 180-7. PMID 23178523 DOI: 10.1016/J.Ejphar.2012.11.008  0.496
2013 Moritz AE, Foster JD, Gorentla BK, Mazei-Robison MS, Yang JW, Sitte HH, Blakely RD, Vaughan RA. Phosphorylation of dopamine transporter serine 7 modulates cocaine analog binding. The Journal of Biological Chemistry. 288: 20-32. PMID 23161550 DOI: 10.1074/Jbc.M112.407874  0.4
2013 Baumann MH, Partilla JS, Lehner KR, Thorndike EB, Hoffman AF, Holy M, Rothman RB, Goldberg SR, Lupica CR, Sitte HH, Brandt SD, Tella SR, Cozzi NV, Schindler CW. Powerful cocaine-like actions of 3,4-methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive 'bath salts' products. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 552-62. PMID 23072836 DOI: 10.1038/Npp.2012.204  0.464
2013 Zdrazil B, Jurik A, Sitte HH, Ecker GF. Pairwise structural comparison of tiagabine analogs gives new insights into their protein binding modes Journal of Cheminformatics. 5. DOI: 10.1186/1758-2946-5-S1-P32  0.408
2012 Steinkellner T, Yang JW, Montgomery TR, Chen WQ, Winkler MT, Sucic S, Lubec G, Freissmuth M, Elgersma Y, Sitte HH, Kudlacek O. Ca(2+)/calmodulin-dependent protein kinase IIα (αCaMKII) controls the activity of the dopamine transporter: implications for Angelman syndrome. The Journal of Biological Chemistry. 287: 29627-35. PMID 22778257 DOI: 10.1074/Jbc.M112.367219  0.47
2012 Foster JD, Yang JW, Moritz AE, Challasivakanaka S, Smith MA, Holy M, Wilebski K, Sitte HH, Vaughan RA. Dopamine transporter phosphorylation site threonine 53 regulates substrate reuptake and amphetamine-stimulated efflux. The Journal of Biological Chemistry. 287: 29702-12. PMID 22722938 DOI: 10.1186/2050-6511-13-S1-A45  0.498
2012 Bulling S, Schicker K, Zhang YW, Steinkellner T, Stockner T, Gruber CW, Boehm S, Freissmuth M, Rudnick G, Sitte HH, Sandtner W. The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transporters. The Journal of Biological Chemistry. 287: 18524-34. PMID 22451652 DOI: 10.1074/Jbc.M112.343681  0.556
2012 Brast S, Grabner A, Sucic S, Sitte HH, Hermann E, Pavenstädt H, Schlatter E, Ciarimboli G. The cysteines of the extracellular loop are crucial for trafficking of human organic cation transporter 2 to the plasma membrane and are involved in oligomerization. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 976-86. PMID 22085643 DOI: 10.1096/Fj.11-180679  0.444
2012 Schicker K, Uzelac Z, Gesmonde J, Bulling S, Stockner T, Freissmuth M, Boehm S, Rudnick G, Sitte HH, Sandtner W. Unifying concept of serotonin transporter-associated currents. The Journal of Biological Chemistry. 287: 438-45. PMID 22072712 DOI: 10.1074/Jbc.M111.304261  0.453
2012 Wildling L, Rankl C, Haselgrübler T, Gruber HJ, Holy M, Newman AH, Zou MF, Zhu R, Freissmuth M, Sitte HH, Hinterdorfer P. Probing binding pocket of serotonin transporter by single molecular force spectroscopy on living cells. The Journal of Biological Chemistry. 287: 105-13. PMID 22033932 DOI: 10.1074/Jbc.M111.304873  0.493
2012 Mayer FP, Schmid D, Holy M, Yang J, Salzer I, Boehm S, Chiba P, Sitte HH. Real-time uptake of fluorescent ASP+ via the organic cation transporter 3 Bmc Pharmacology and Toxicology. 13: A80. DOI: 10.1186/2050-6511-13-S1-A80  0.48
2012 Jayaraman K, Sohail A, Freissmuth M, Sitte HH, Stockner T. Identifying forces that stabilize the oligomeric state of bacterial homologs of neurotransmitter transporters Bmc Pharmacology and Toxicology. 13: A59. DOI: 10.1186/2050-6511-13-S1-A59  0.452
2012 Venkatesan S, Sohail A, Sandtner W, Stockner T, Ecker GF, Sitte HH. Deciphering structural rearrangements during transport process in the bacterial transporter GltPh, homolog to mammalian glutamate transporter Bmc Pharmacology and Toxicology. 13: A57. DOI: 10.1186/2050-6511-13-S1-A57  0.489
2012 Steinkellner T, Montgomery T, Yang J, Rickhag M, Sucic S, Elgersma Y, Kudlacek O, Freissmuth M, Gether U, Sitte HH. Calmodulin kinase II regulates amphetamine-induced reverse transport in dopamine and serotonin transporters Bmc Pharmacology and Toxicology. 13. DOI: 10.1186/2050-6511-13-S1-A56  0.554
2012 Sucic S, Kern C, Sitte HH, Freissmuth M. The N-terminus acts as a lever to support amphetamine-induced substrate efflux by the serotonin transporter Bmc Pharmacology and Toxicology. 13. DOI: 10.1186/2050-6511-13-S1-A54  0.437
2012 Sohail A, Bulling S, Stolt-Bergner P, Kudlacek O, Ecker GF, Freissmuth M, Stockner T, Sitte HH, Sandtner W. Decrypting structural and functional changes in LeuTAa at atomic level employing LRET Bmc Pharmacology and Toxicology. 13: A53. DOI: 10.1186/2050-6511-13-S1-A53  0.396
2012 Saha K, Venkatesan S, Sohail A, Stockner T, Bulling S, Ecker GF, Sitte HH, Sandtner W. LRET-based distance measurements in the mammalian glutamate transporter EAAT3 Bmc Pharmacology and Toxicology. 13: A52. DOI: 10.1186/2050-6511-13-S1-A52  0.369
2012 Zdrazil B, Jurik A, Reicherstorfer R, Stockner T, Sitte HH, Ecker GF. Insights into binding events of GABA- and Tiagabine- analogues in the Gamma-Aminobutyric Acid Transporter 1 by means of Molecular Modelling Journal of Cheminformatics. 4. DOI: 10.1186/1758-2946-4-S1-P54  0.424
2012 Sandtner W, Schicker K, Freissmuth M, Rudnick G, Sitte HH. A Unifying Concept of Serotonin Transporter Associated Currents Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.3875  0.459
2011 Navaroli DM, Stevens ZH, Uzelac Z, Gabriel L, King MJ, Lifshitz LM, Sitte HH, Melikian HE. The plasma membrane-associated GTPase Rin interacts with the dopamine transporter and is required for protein kinase C-regulated dopamine transporter trafficking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 13758-70. PMID 21957239 DOI: 10.1523/Jneurosci.2649-11.2011  0.466
2011 Keller T, Egenberger B, Gorboulev V, Bernhard F, Uzelac Z, Gorbunov D, Wirth C, Koppatz S, Dötsch V, Hunte C, Sitte HH, Koepsell H. The large extracellular loop of organic cation transporter 1 influences substrate affinity and is pivotal for oligomerization. The Journal of Biological Chemistry. 286: 37874-86. PMID 21896487 DOI: 10.1074/Jbc.M111.289330  0.467
2011 Grabner A, Brast S, Sucic S, Bierer S, Hirsch B, Pavenstädt H, Sitte HH, Schlatter E, Ciarimboli G. LAPTM4A interacts with hOCT2 and regulates its endocytotic recruitment. Cellular and Molecular Life Sciences : Cmls. 68: 4079-90. PMID 21553234 DOI: 10.1007/S00018-011-0694-6  0.413
2011 Sucic S, El-Kasaby A, Kudlacek O, Sarker S, Sitte HH, Marin P, Freissmuth M. The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C. The Journal of Biological Chemistry. 286: 16482-90. PMID 21454670 DOI: 10.1074/Jbc.M111.230037  0.767
2011 Montgomery T, Sucic S, Steinkellner T, Freissmuth M, Sitte H. Differential regulation of amphetamine-induced serotonergic and dopaminergic efflux by syntaxin 1A Bmc Pharmacology. 11: A38. DOI: 10.1186/1471-2210-11-S2-A38  0.483
2011 Sohail A, Stolt-Bergner P, Ecker GF, Freissmuth M, Stockner T, Sitte HH, Sandtner W. LRET-based intramolecular distance measurements in LeuTAa Bmc Pharmacology. 11: A21. DOI: 10.1186/1471-2210-11-S2-A21  0.443
2011 Sucic S, Kern C, Vidovic D, Sarker S, Kudlacek O, Sitte HH, Freissmuth M. Truncations in the amino terminus reveal a region key to supporting amphetamine-induced efflux by the human serotonin transporter Bmc Pharmacology. 11: A20. DOI: 10.1186/1471-2210-11-S2-A20  0.768
2011 Buchmayer F, Schicker K, Stübiger G, Hamilton PJ, Geier P, Jurik A, Weissensteiner R, Steinkellner T, Matthies HJ, Montgomery T, Winkler M, Yang J, Holy M, Ecker GF, Galli A, ... ... Sitte HH, et al. Amphetamine actions rely on the availability of phosphatidylinositol-4,5-bisphosphate Bmc Pharmacology. 11: A19. DOI: 10.1186/1471-2210-11-S2-A19  0.425
2011 Scharinger C, Kasess C, Huf W, Kalcher K, Esterbauer H, Sitte H, Kasper S, Moser E, Pezawas L. P02-89 - Peripheral serotonin uptake is related to neural activation in the cingulate cortex European Psychiatry. 26: 684-684. DOI: 10.1016/S0924-9338(11)72390-2  0.303
2011 Bulling SJ, Sandtner W, Uzelac Z, Sitte H. Lithium Stabilizes the Inward Facing Conformation of Human Serotonin Transporter (hSERT) Biophysical Journal. 100: 135a. DOI: 10.1016/J.Bpj.2010.12.944  0.432
2011 Sandtner W, Bulling S, Schicker K, Gruber C, Sitte H. Effects by Ibogaine on the Dopamine Transporter Biophysical Journal. 100: 135a. DOI: 10.1016/J.Bpj.2010.12.943  0.525
2010 El-Kasaby A, Just H, Malle E, Stolt-Bergner PC, Sitte HH, Freissmuth M, Kudlacek O. Mutations in the carboxyl-terminal SEC24 binding motif of the serotonin transporter impair folding of the transporter. The Journal of Biological Chemistry. 285: 39201-10. PMID 20889976 DOI: 10.1074/Jbc.M110.118000  0.541
2010 Sarker S, Weissensteiner R, Steiner I, Sitte HH, Ecker GF, Freissmuth M, Sucic S. The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter. Molecular Pharmacology. 78: 1026-35. PMID 20829432 DOI: 10.1124/Mol.110.067538  0.745
2010 Sucic S, Dallinger S, Zdrazil B, Weissensteiner R, Jørgensen TN, Holy M, Kudlacek O, Seidel S, Cha JH, Gether U, Newman AH, Ecker GF, Freissmuth M, Sitte HH. The N terminus of monoamine transporters is a lever required for the action of amphetamines. The Journal of Biological Chemistry. 285: 10924-38. PMID 20118234 DOI: 10.1074/Jbc.M109.083154  0.538
2010 Sitte HH, Freissmuth M. The reverse operation of Na(+)/Cl(-)-coupled neurotransmitter transporters--why amphetamines take two to tango. Journal of Neurochemistry. 112: 340-55. PMID 19891736 DOI: 10.1111/J.1471-4159.2009.06474.X  0.511
2010 Sohail A, Stolt-Bergner P, Ecker GF, Freissmuth M, Sitte H, Sandtner W. Luminescence resonance energy transfer-based intramolecular distance measurements in leucine transporter from Aquifex aeolicus Bmc Pharmacology. 10. DOI: 10.1186/1471-2210-10-S1-A31  0.453
2010 Stockner T, Sitte HH, Chiba P. Conformation of membrane-inserted P-glycoprotein Bmc Pharmacology. 10. DOI: 10.1186/1471-2210-10-S1-A27  0.386
2010 Montgomery T, Sitte H, McBean G. 4-Methylthioamphetamine (4-MTA) induces mitochondrial-dependent apoptosis in SH-SY5Y cells independently of dopamine and noradrenaline transporters Bmc Pharmacology. 10. DOI: 10.1186/1471-2210-10-S1-A22  0.395
2010 Steinkellner T, Kudlacek O, Freissmuth M, Elgersma Y, Sitte H. Calmodulin kinase II regulates amphetamine-induced reverse transport in the dopamine transporter: implications for the importance of the dopamine transporter in Angelman syndrome Bmc Pharmacology. 10. DOI: 10.1186/1471-2210-10-S1-A19  0.52
2010 El-Kasaby A, Just H, Sitte H, Kudlacek O, Freissmuth M. The role of the carboxyl terminus in folding of the serotonin transporter Bmc Pharmacology. 10. DOI: 10.1186/1471-2210-10-S1-A18  0.519
2010 Sucic S, El-Kasaby A, Sarker S, Sitte HH, Marin P, Freissmuth M. Concentrative ER export of the serotonin transporter relies exclusively on an interaction with Sec24C Bmc Pharmacology. 10. DOI: 10.1186/1471-2210-10-S1-A11  0.79
2009 Egaña LA, Cuevas RA, Baust TB, Parra LA, Leak RK, Hochendoner S, Peña K, Quiroz M, Hong WC, Dorostkar MM, Janz R, Sitte HH, Torres GE. Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 4592-604. PMID 19357284 DOI: 10.1523/Jneurosci.4559-08.2009  0.493
2009 Maier S, Reiterer V, Ruggiero AM, Rothstein JD, Thomas S, Dahm R, Sitte HH, Farhan H. GTRAP3-18 serves as a negative regulator of Rab1 in protein transport and neuronal differentiation. Journal of Cellular and Molecular Medicine. 13: 114-24. PMID 18363836 DOI: 10.1111/J.1582-4934.2008.00303.X  0.433
2009 Sandtner W, Gerstbrein K, Sitte HH. A relationship between membrane permeability of amphetamines and serotonin efflux via serotonin transporters Bmc Pharmacology. 9: A37. DOI: 10.1186/1471-2210-9-S2-A37  0.376
2009 Sucic S, Dallinger S, Zdrazil B, Kudlacek O, Sandtner W, Ecker GF, Freissmuth M, Sitte HH. Mutations in the amino-terminus impair amphetamine-induced efflux by inducing inward-facing conformations of the serotonin transporter Bmc Pharmacology. 9: A12. DOI: 10.1186/1471-2210-9-S2-A12  0.427
2008 Reiterer V, Maier S, Sitte HH, Kriz A, Rüegg MA, Hauri HP, Freissmuth M, Farhan H. Sec24- and ARFGAP1-dependent trafficking of GABA transporter-1 is a prerequisite for correct axonal targeting. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12453-64. PMID 19020038 DOI: 10.1523/Jneurosci.3451-08.2008  0.401
2008 Mazei-Robison MS, Bowton E, Holy M, Schmudermaier M, Freissmuth M, Sitte HH, Galli A, Blakely RD. Anomalous dopamine release associated with a human dopamine transporter coding variant. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 7040-6. PMID 18614672 DOI: 10.1523/Jneurosci.0473-08.2008  0.434
2008 Madsen KL, Eriksen J, Milan-Lobo L, Han DS, Niv MY, Ammendrup-Johnsen I, Henriksen U, Bhatia VK, Stamou D, Sitte HH, McMahon HT, Weinstein H, Gether U. Membrane localization is critical for activation of the PICK1 BAR domain. Traffic (Copenhagen, Denmark). 9: 1327-43. PMID 18466293 DOI: 10.1111/J.1600-0854.2008.00761.X  0.306
2008 Korkhov VM, Milan-Lobo L, Zuber B, Farhan H, Schmid JA, Freissmuth M, Sitte HH. Peptide-based interactions with calnexin target misassembled membrane proteins into endoplasmic reticulum-derived multilamellar bodies. Journal of Molecular Biology. 378: 337-52. PMID 18367207 DOI: 10.1016/J.Jmb.2008.02.056  0.413
2008 Mao Y, Mathewson L, Gesmonde J, Sato Y, Holy M, Sitte HH, Rudnick G. Involvement of serotonin transporter extracellular loop 1 in serotonin binding and transport. Molecular Membrane Biology. 25: 115-27. PMID 18307099 DOI: 10.1080/09687680701633257  0.534
2008 Farhan H, Reiterer V, Kriz A, Hauri HP, Pavelka M, Sitte HH, Freissmuth M. Signal-dependent export of GABA transporter 1 from the ER-Golgi intermediate compartment is specified by a C-terminal motif. Journal of Cell Science. 121: 753-61. PMID 18285449 DOI: 10.1242/Jcs.017681  0.42
2008 Bartholomäus I, Milan-Lobo L, Nicke A, Dutertre S, Hastrup H, Jha A, Gether U, Sitte HH, Betz H, Eulenburg V. Glycine transporter dimers: Evidence for occurrence in the plasma membrane Journal of Biological Chemistry. 283: 10978-10991. PMID 18252709 DOI: 10.1074/Jbc.M800622200  0.431
2008 Gobbi M, Funicello M, Gerstbrein K, Holy M, Moya PR, Sotomayor R, Forray MI, Gysling K, Paluzzi S, Bonanno G, Reyes-Parada M, Sitte HH, Mennini T. N,N-dimethyl-thioamphetamine and methyl-thioamphetamine, two non-neurotoxic substrates of 5-HT transporters, have scant in vitro efficacy for the induction of transporter-mediated 5-HT release and currents. Journal of Neurochemistry. 105: 1770-80. PMID 18248615 DOI: 10.1111/J.1471-4159.2008.05272.X  0.402
2008 Ruggiero AM, Liu Y, Vidensky S, Maier S, Jung E, Farhan H, Robinson MB, Sitte HH, Rothstein JD. The endoplasmic reticulum exit of glutamate transporter is regulated by the inducible mammalian Yip6b/GTRAP3-18 protein. The Journal of Biological Chemistry. 283: 6175-83. PMID 18167356 DOI: 10.1074/Jbc.M701008200  0.423
2008 Liu Y, Vidensky S, Ruggiero AM, Maier S, Sitte HH, Rothstein JD. Reticulon RTN2B regulates trafficking and function of neuronal glutamate transporter EAAC1. The Journal of Biological Chemistry. 283: 6561-71. PMID 18096700 DOI: 10.1074/Jbc.M708096200  0.455
2008 Loland CJ, Desai RI, Zou MF, Cao J, Grundt P, Gerstbrein K, Sitte HH, Newman AH, Katz JL, Gether U. Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors. Molecular Pharmacology. 73: 813-23. PMID 17978168 DOI: 10.1124/Mol.107.039800  0.457
2008 Willeit M, Sitte HH, Thierry N, Michalek K, Praschak-Rieder N, Zill P, Winkler D, Brannath W, Fischer MB, Bondy B, Kasper S, Singer EA. Enhanced serotonin transporter function during depression in seasonal affective disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 1503-13. PMID 17882235 DOI: 10.1038/Sj.Npp.1301560  0.423
2008 Buchmayer F, Schicker K, Holy M, Kudlacek O, Boehm S, Sitte HH. The presence of phosphatidylinositol-4,5-bisphosphate directly impacts on amphetamine-induced serotonin transporter-mediated efflux Bmc Pharmacology. 8: A46. DOI: 10.1186/1471-2210-8-S1-A46  0.479
2007 Schuster C, Fernbach N, Rix U, Superti-Furga G, Holy M, Freissmuth M, Sitte HH, Sexl V. Selective serotonin reuptake inhibitors--a new modality for the treatment of lymphoma/leukaemia? Biochemical Pharmacology. 74: 1424-35. PMID 17709099 DOI: 10.1186/1471-2210-7-S2-A8  0.335
2007 Farhan H, Reiterer V, Korkhov VM, Schmid JA, Freissmuth M, Sitte HH. Concentrative export from the endoplasmic reticulum of the gamma-aminobutyric acid transporter 1 requires binding to SEC24D. The Journal of Biological Chemistry. 282: 7679-89. PMID 17210573 DOI: 10.1074/Jbc.M609720200  0.479
2007 Farhan H, Freissmuth M, Sitte HH. Oligomerization of neurotransmitter transporters: a ticket from the endoplasmic reticulum to the plasma membrane. Handbook of Experimental Pharmacology. 233-49. PMID 16722239 DOI: 10.1007/3-540-29784-7_12  0.508
2007 Gerstbrein K, Sitte HH. Currents in neurotransmitter transporters. Handbook of Experimental Pharmacology. 95-111. PMID 16722232 DOI: 10.1007/3-540-29784-7_5  0.458
2007 Korkhov VM, Milan-Lobo L, Farhan H, Schmid JA, Freissmuth M, Sitte HH. Peptide-based interactions with calnexin target misassembled GABA transporter-1 molecules into organized smooth endoplasmic reticulum compartments* Bmc Pharmacology. 7: A77. DOI: 10.1186/1471-2210-7-S2-A77  0.349
2006 Fog JU, Khoshbouei H, Holy M, Owens WA, Vaegter CB, Sen N, Nikandrova Y, Bowton E, McMahon DG, Colbran RJ, Daws LC, Sitte HH, Javitch JA, Galli A, Gether U. Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport. Neuron. 51: 417-29. PMID 16908408 DOI: 10.1016/J.Neuron.2006.06.028  0.473
2006 Korkhov VM, Holy M, Freissmuth M, Sitte HH. The conserved glutamate (Glu136) in transmembrane domain 2 of the serotonin transporter is required for the conformational switch in the transport cycle. The Journal of Biological Chemistry. 281: 13439-48. PMID 16527819 DOI: 10.1074/Jbc.M511382200  0.486
2005 Hilber B, Scholze P, Dorostkar MM, Sandtner W, Holy M, Boehm S, Singer EA, Sitte HH. Serotonin-transporter mediated efflux: a pharmacological analysis of amphetamines and non-amphetamines. Neuropharmacology. 49: 811-9. PMID 16185723 DOI: 10.1016/J.Neuropharm.2005.08.008  0.543
2005 Kniazeff J, Loland CJ, Goldberg N, Quick M, Das S, Sitte HH, Javitch JA, Gether U. Intramolecular cross-linking in a bacterial homolog of mammalian SLC6 neurotransmitter transporters suggests an evolutionary conserved role of transmembrane segments 7 and 8. Neuropharmacology. 49: 715-23. PMID 16129457 DOI: 10.1016/J.Neuropharm.2005.07.003  0.535
2005 Seidel S, Singer EA, Just H, Farhan H, Scholze P, Kudlacek O, Holy M, Koppatz K, Krivanek P, Freissmuth M, Sitte HH. Amphetamines take two to tango: an oligomer-based counter-transport model of neurotransmitter transport explores the amphetamine action. Molecular Pharmacology. 67: 140-51. PMID 15615700 DOI: 10.1124/Mol.67.1.140  0.54
2004 Korkhov VM, Farhan H, Freissmuth M, Sitte HH. Oligomerization of the {gamma}-aminobutyric acid transporter-1 is driven by an interplay of polar and hydrophobic interactions in transmembrane helix II. The Journal of Biological Chemistry. 279: 55728-36. PMID 15496410 DOI: 10.1074/Jbc.M409449200  0.391
2004 Meinild AK, Sitte HH, Gether U. Zinc potentiates an uncoupled anion conductance associated with the dopamine transporter. The Journal of Biological Chemistry. 279: 49671-9. PMID 15358780 DOI: 10.1074/Jbc.M407660200  0.48
2004 Farhan H, Korkhov VM, Paulitschke V, Dorostkar MM, Scholze P, Kudlacek O, Freissmuth M, Sitte HH. Two discontinuous segments in the carboxyl terminus are required for membrane targeting of the rat gamma-aminobutyric acid transporter-1 (GAT1). The Journal of Biological Chemistry. 279: 28553-63. PMID 15073174 DOI: 10.1074/Jbc.M307325200  0.413
2004 Sitte HH, Farhan H, Javitch JA. Sodium-dependent neurotransmitter transporters: oligomerization as a determinant of transporter function and trafficking. Molecular Interventions. 4: 38-47. PMID 14993475 DOI: 10.1124/Mi.4.1.38  0.466
2004 Just H, Sitte HH, Schmid JA, Freissmuth M, Kudlacek O. Identification of an additional interaction domain in transmembrane domains 11 and 12 that supports oligomer formation in the human serotonin transporter. The Journal of Biological Chemistry. 279: 6650-7. PMID 14660642 DOI: 10.1074/Jbc.M306092200  0.428
2003 Sitte HH, Freissmuth M. Oligomer formation by Na+-Cl--coupled neurotransmitter transporters. European Journal of Pharmacology. 479: 229-36. PMID 14612153 DOI: 10.1016/J.Ejphar.2003.08.072  0.482
2002 Scholze P, Freissmuth M, Sitte HH. Mutations within an intramembrane leucine heptad repeat disrupt oligomer formation of the rat GABA transporter 1. The Journal of Biological Chemistry. 277: 43682-90. PMID 12223478 DOI: 10.1074/Jbc.M205602200  0.476
2002 Scholze P, Nørregaard L, Singer EA, Freissmuth M, Gether U, Sitte HH. The role of zinc ions in reverse transport mediated by monoamine transporters. The Journal of Biological Chemistry. 277: 21505-13. PMID 11940571 DOI: 10.1074/Jbc.M112265200  0.515
2002 Sitte HH, Singer EA, Scholze P. Bi-directional transport of GABA in human embryonic kidney (HEK-293) cells stably expressing the rat GABA transporter GAT-1. British Journal of Pharmacology. 135: 93-102. PMID 11786484 DOI: 10.1038/Sj.Bjp.0704446  0.37
2001 Scholze P, Sitte HH, Singer EA. Substantial loss of substrate by diffusion during uptake in HEK-293 cells expressing neurotransmitter transporters. Neuroscience Letters. 309: 173-6. PMID 11514069 DOI: 10.1016/S0304-3940(01)02058-4  0.402
2001 Sitte HH, Hiptmair B, Zwach J, Pifl C, Singer EA, Scholze P. Quantitative analysis of inward and outward transport rates in cells stably expressing the cloned human serotonin transporter: inconsistencies with the hypothesis of facilitated exchange diffusion. Molecular Pharmacology. 59: 1129-37. PMID 11306696 DOI: 10.1124/Mol.59.5.1129  0.459
2001 Sitte H. The impact of oligomerization on the function of the serotonin transporter Biochemical Society Transactions. 29: A96-A96. DOI: 10.1042/Bst029A096B  0.482
2001 Schmid JA, Just H, Sitte HH. Impact of oligomerization on the function of the human serotonin transporter Biochemical Society Transactions. 29: 732-736. DOI: 10.1042/Bst0290732  0.485
2000 Schmid JA, Scholze P, Kudlacek O, Freissmuth M, Singer EA, Sitte HH. Oligomerization of the human serotonin transporter and of the rat GABA transporter 1 visualized by fluorescence resonance energy transfer microscopy in living cells. The Journal of Biological Chemistry. 276: 3805-10. PMID 11071889 DOI: 10.1074/Jbc.M007357200  0.466
2000 Sitte HH, Scholze P, Schloss P, Pifl C, Singer EA. Characterization of carrier-mediated efflux in human embryonic kidney 293 cells stably expressing the rat serotonin transporter: a superfusion study. Journal of Neurochemistry. 74: 1317-24. PMID 10693966 DOI: 10.1046/J.1471-4159.2000.741317.X  0.401
2000 Pifl C, Sitte HH, Reither H, Singer EA. The mechanism of the releasing action of amphetamine. Uptake, superfusion, and electrophysiological studies on transporter-transfected cells Pure and Applied Chemistry. 72: 1045-1050. DOI: 10.1351/pac200072061045  0.464
2000 Pifl C, Sitte HH, Reither H, Singer EA. The mechanism of the releasing action of amphetamine. Uptake, superfusion, and electrophysiological studies on transporter-transfected cells Pure and Applied Chemistry. 72: 1045-1050. DOI: 10.1351/Pac200072061045  0.549
1999 Pifl C, Agneter E, Drobny H, Sitte HH, Singer EA. Amphetamine reverses or blocks the operation of the human noradrenaline transporter depending on its concentration: superfusion studies on transfected cells. Neuropharmacology. 38: 157-65. PMID 10193907 DOI: 10.1016/S0028-3908(98)00155-5  0.464
1998 Sitte HH, Huck S, Reither H, Boehm S, Singer EA, Pifl C. Carrier-mediated release, transport rates, and charge transfer induced by amphetamine, tyramine, and dopamine in mammalian cells transfected with the human dopamine transporter. Journal of Neurochemistry. 71: 1289-97. PMID 9721755 DOI: 10.1046/J.1471-4159.1998.71031289.X  0.471
1995 Agneter E, Sitte HH, Stöckl-Hiesleitner S, Fischer-Colbrie R, Winkler H, Singer EA. Sustained dopamine release induced by secretoneurin in the striatum of the rat: a microdialysis study. Journal of Neurochemistry. 65: 622-5. PMID 7616217 DOI: 10.1046/J.1471-4159.1995.65020622.X  0.329
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