kun ping lu - Publications

Affiliations: 
Medicine Harvard Medical School, Boston, MA, United States 

137 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Lu KP, Zhou XZ. Pin1-catalyzed conformational regulation after phosphorylation: A distinct checkpoint in cell signaling and drug discovery. Science Signaling. 17: eadi8743. PMID 38889227 DOI: 10.1126/scisignal.adi8743  0.318
2024 Jeong J, Usman M, Li Y, Zhou XZ, Lu KP. Pin1-Catalyzed Conformation Changes Regulate Protein Ubiquitination and Degradation. Cells. 13. PMID 38727267 DOI: 10.3390/cells13090731  0.314
2024 Ke S, Dang F, Wang L, Chen JY, Naik MT, Li W, Thavamani A, Kim N, Naik NM, Sui H, Tang W, Qiu C, Koikawa K, Batalini F, Stern Gatof E, ... ... Lu KP, et al. Reciprocal antagonism of PIN1-APC/C governs mitotic protein stability and cell cycle entry. Nature Communications. 15: 3220. PMID 38622115 DOI: 10.1038/s41467-024-47427-w  0.315
2023 Wang R, Lu KP, Zhou XZ. Function and regulation of cis P-tau in the pathogenesis and treatment of conventional and nonconventional tauopathies. Journal of Neurochemistry. PMID 37638382 DOI: 10.1111/jnc.15909  0.349
2021 Qiu C, Albayram O, Kondo A, Wang B, Kim N, Arai K, Tsai CY, Bassal MA, Herbert MK, Washida K, Angeli P, Kozono S, Stucky JE, Baxley S, Lin YM, ... ... Lu KP, et al. Cis P-tau underlies vascular contribution to cognitive impairment and dementia and can be effectively targeted by immunotherapy in mice. Science Translational Medicine. 13. PMID 34078745 DOI: 10.1126/scitranslmed.aaz7615  0.703
2020 Pinch BJ, Doctor ZM, Nabet B, Browne CM, Seo HS, Mohardt ML, Kozono S, Lian X, Manz TD, Chun Y, Kibe S, Zaidman D, Daitchman D, Yeoh ZC, Vangos NE, ... ... Lu KP, et al. Identification of a potent and selective covalent Pin1 inhibitor. Nature Chemical Biology. PMID 32483379 DOI: 10.1038/S41589-020-0550-9  0.345
2020 Chen D, Mei Y, Kim N, Lan G, Gan CL, Fan F, Zhang T, Xia Y, Wang L, Lin C, Ke F, Zhou XZ, Lu KP, Lee TH. Melatonin Directly Binds and Inhibits Death-Associated Protein Kinase 1 Function in Alzheimer's Disease. Journal of Pineal Research. e12665. PMID 32358852 DOI: 10.1111/jpi.12665  0.339
2020 Luo ML, Zheng F, Chen W, Liang ZM, Chandramouly G, Tan J, Willis NA, Chen CH, de Oliveira Taveira M, Zhou XZ, Lu KP, Scully R, Wulf GM, Hu H. Inactivation of the prolyl isomerase Pin1 sensitizes BRCA1-proficient breast cancer to PARP inhibition. Cancer Research. PMID 32193285 DOI: 10.1158/0008-5472.Can-19-2739  0.319
2019 Albayram O, MacIver B, Mathai J, Verstegen A, Baxley S, Qiu C, Bell C, Caldarone BJ, Zhou XZ, Lu KP, Zeidel M. Traumatic Brain Injury-related voiding dysfunction in mice is caused by damage to rostral pathways, altering inputs to the reflex pathways. Scientific Reports. 9: 8646. PMID 31201348 DOI: 10.1038/S41598-019-45234-8  0.691
2019 Chen L, Xu X, Wen X, Xu S, Wang L, Lu W, Jiang M, Huang J, Yang D, Wang J, Zheng M, Zhou XZ, Lu KP, Liu H. Targeting PIN1 exerts potent antitumor activity in pancreatic ductal carcinoma via inhibiting tumor metastasis. Cancer Science. PMID 31148345 DOI: 10.1111/Cas.14085  0.334
2019 Zhang Z, Yu W, Zheng M, Liao X, Wang J, Yang D, Lu W, Wang L, Zhang S, Liu H, Zhou XZ, Lu KP. Pin1 inhibition potently suppresses gastric cancer growth and blocks PI3K/AKT and Wnt/β-catenin oncogenic pathways. Molecular Carcinogenesis. PMID 31026381 DOI: 10.1002/Mc.23027  0.322
2019 Pinch B, Doctor Z, Browne CM, Seo H, Nabet B, Kozono S, Lian X, Zaidman D, Daitchman D, London N, Gong L, Manz T, Chun Y, Tan L, Marto J, ... ... Lu KP, et al. Abstract 2757: Discovery and characterization of covalent Pin1 inhibitors targeted to an active site cysteine Cancer Research. 79: 2757-2757. DOI: 10.1158/1538-7445.Am2019-2757  0.352
2019 Goldstein L, Minaeva O, Fisher AM, Tagge CA, Moncaster JA, Gaudreau-Balderrama A, Zhang X, Wojnarowicz MW, Babcock KJ, Franz ES, Chancellor SE, Pietro JH, O'Brien JW, Liu X, Casey NF, ... ... Lu KP, et al. P2-206: CONTRIBUTION OF FOCAL MICROVASCULAR DISRUPTION TO NEUROINFLAMMATION AND TAU PATHOLOGY IN A MOUSE MODEL OF IMPACT CONCUSSION AND CHRONIC TRAUMATIC ENCEPHALOPATHY Alzheimer's & Dementia. 15: P655-P656. DOI: 10.1016/J.Jalz.2019.06.2613  0.354
2018 Zhang J, Chen M, Zhu Y, Dai X, Dang F, Ren J, Ren S, Shulga YV, Beca F, Gan W, Wu F, Lin YM, Zhou X, DeCaprio JA, Beck AH, ... Lu KP, et al. SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression. Developmental Cell. PMID 30595538 DOI: 10.1016/J.Devcel.2018.11.035  0.322
2018 Albayram O, Angeli P, Bernstein E, Baxley S, Gao Z, Lu KP, Zhou XZ. Targeting Prion-like Cis Phosphorylated Tau Pathology in Neurodegenerative Diseases. Journal of Alzheimer's Disease & Parkinsonism. 8. PMID 30197831 DOI: 10.4172/2161-0460.1000443  0.732
2018 Kozono S, Lin YM, Seo HS, Pinch B, Lian X, Qiu C, Herbert MK, Chen CH, Tan L, Gao ZJ, Massefski W, Doctor ZM, Jackson BP, Chen Y, Dhe-Paganon S, ... Lu KP, et al. Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells. Nature Communications. 9: 3069. PMID 30093655 DOI: 10.1038/S41467-018-05402-2  0.346
2018 Lian X, Lin YM, Kozono S, Herbert MK, Li X, Yuan X, Guo J, Guo Y, Tang M, Lin J, Huang Y, Wang B, Qiu C, Tsai CY, Xie J, ... ... Lu K, et al. Pin1 inhibition exerts potent activity against acute myeloid leukemia through blocking multiple cancer-driving pathways. Journal of Hematology & Oncology. 11: 73. PMID 29848341 DOI: 10.1186/S13045-018-0611-7  0.321
2017 Shahpasand K, Shamloo AS, Nabavi SM, Zhou XZ, Lu KP. "Tau Immunotherapy: Hopes and Hindrances". Human Vaccines & Immunotherapeutics. 0. PMID 29049003 DOI: 10.1080/21645515.2017.1393594  0.41
2017 Albayram O, Kondo A, Mannix R, Smith C, Tsai CY, Li C, Herbert MK, Qiu J, Monuteaux M, Driver J, Yan S, Gormley W, Puccio AM, Okonkwo DO, Lucke-Wold B, ... ... Lu KP, et al. Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae. Nature Communications. 8: 1000. PMID 29042562 DOI: 10.1038/S41467-017-01068-4  0.717
2017 Frain L, Swanson D, Cho K, Gagnon D, Lu KP, Betensky RA, Driver J. Association of cancer and Alzheimer's disease risk in a national cohort of veterans. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28711346 DOI: 10.1016/J.Jalz.2017.04.012  0.305
2017 Hu X, Dong SH, Chen J, Zhou XZ, Chen R, Nair S, Lu KP, Chen LF. Prolyl isomerase PIN1 regulates the stability, transcriptional activity and oncogenic potential of BRD4. Oncogene. PMID 28481868 DOI: 10.1038/Onc.2017.137  0.378
2017 Liao XH, Zhang AL, Zheng M, Li MQ, Chen CP, Xu H, Chu QS, Yang D, Lu W, Tsai TF, Liu H, Zhou XZ, Lu KP. Chemical or genetic Pin1 inhibition exerts potent anticancer activity against hepatocellular carcinoma by blocking multiple cancer-driving pathways. Scientific Reports. 7: 43639. PMID 28262728 DOI: 10.1038/Srep43639  0.313
2017 Kondo A, Albayram O, Zhou XZ, Lu KP. Pin1 Knockout Mice: A Model for the Study of Tau Pathology in Alzheimer's Disease. Methods in Molecular Biology (Clifton, N.J.). 1523: 415-425. PMID 27975268 DOI: 10.1007/978-1-4939-6598-4_28  0.693
2016 Albayram O, Herbert MK, Kondo A, Tsai CY, Baxley S, Lian X, Hansen M, Zhou XZ, Lu KP. Function and regulation of tau conformations in the development and treatment of traumatic brain injury and neurodegeneration. Cell & Bioscience. 6: 59. PMID 27980715 DOI: 10.1186/S13578-016-0124-4  0.724
2016 Rogals MJ, Greenwood AI, Kwon J, Lu KP, Nicholson LK. Neighboring phospho-Ser-Pro motifs in the undefined domain of IRAK1 impart bivalent advantage for Pin1 binding. The Febs Journal. PMID 27790836 DOI: 10.1111/Febs.13943  0.339
2016 Fisher CL, Resnick RJ, De S, Acevedo LA, Lu KP, Schroeder FC, Nicholson LK. Cyclic cis-Locked Phospho-Dipeptides Reduce Entry of AβPP into Amyloidogenic Processing Pathway. Journal of Alzheimer's Disease : Jad. PMID 27662285 DOI: 10.3233/Jad-160051  0.387
2016 Lu KP, Kondo A, Albayram O, Herbert MK, Liu H, Zhou XZ. Potential of the Antibody Against cis-Phosphorylated Tau in the Early Diagnosis, Treatment, and Prevention of Alzheimer Disease and Brain Injury. Jama Neurology. PMID 27654282 DOI: 10.1001/Jamaneurol.2016.2027  0.729
2016 Min SH, Zhou XZ, Lu KP. The role of Pin1 in the development and treatment of cancer. Archives of Pharmacal Research. PMID 27572155 DOI: 10.1007/S12272-016-0821-X  0.42
2016 Chae U, Park SJ, Kim B, Suo W, Min JS, Lee JH, Park SH, Lee AH, Lu KP, Lee DS, Min SH. Critical role of XBP1 in cancer signaling is regulated by PIN1. The Biochemical Journal. PMID 27334111 DOI: 10.1042/Bcj20160482  0.388
2016 Zhou XZ, Lu KP. The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target. Nature Reviews. Cancer. PMID 27256007 DOI: 10.1038/Nrc.2016.49  0.362
2015 Hilton BA, Li Z, Musich PR, Wang H, Cartwright BM, Serrano M, Zhou XZ, Lu KP, Zou Y. ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1. Molecular Cell. PMID 26387736 DOI: 10.1016/J.Molcel.2015.08.008  0.41
2015 Kondo A, Shahpasand K, Mannix R, Qiu J, Moncaster J, Chen CH, Yao Y, Lin YM, Driver JA, Sun Y, Wei S, Luo ML, Albayram O, Huang P, Rotenberg A, ... ... Lu KP, et al. Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy. Nature. PMID 26176913 DOI: 10.1038/Nature14658  0.724
2015 Wei S, Kozono S, Kats L, Nechama M, Li W, Guarnerio J, Luo M, You MH, Yao Y, Kondo A, Hu H, Bozkurt G, Moerke NJ, Cao S, Reschke M, ... ... Lu KP, et al. Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer. Nature Medicine. 21: 457-66. PMID 25849135 DOI: 10.1038/Nm.3839  0.36
2015 Luo ML, Gong C, Chen CH, Hu H, Huang P, Zheng M, Yao Y, Wei S, Wulf G, Lieberman J, Zhou XZ, Song E, Lu KP. The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation. Cell Reports. 11: 111-24. PMID 25818297 DOI: 10.1016/J.Celrep.2015.03.002  0.354
2015 Driver JA, Zhou XZ, Lu KP. Pin1 dysregulation helps to explain the inverse association between cancer and Alzheimer's disease. Biochimica Et Biophysica Acta. PMID 25583562 DOI: 10.1016/J.Bbagen.2014.12.025  0.348
2015 Chen CH, Li W, Sultana R, You MH, Kondo A, Shahpasand K, Kim BM, Luo ML, Nechama M, Lin YM, Yao Y, Lee TH, Zhou XZ, Swomley AM, Allan Butterfield D, ... ... Lu KP, et al. Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease. Neurobiology of Disease. 76: 13-23. PMID 25576397 DOI: 10.1016/J.Nbd.2014.12.027  0.344
2015 Kwon J, Nechama M, Lu KP, Nicholson LK. Mechanisms of Pin1 Regulation of IRAKM Stability in Toll-Like Receptor/Interleukin-1 Receptor Signaling Biophysical Journal. 108: 372a. DOI: 10.1016/J.Bpj.2014.11.2043  0.324
2014 Luo ML, Gong C, Chen CH, Lee DY, Hu H, Huang P, Yao Y, Guo W, Reinhardt F, Wulf G, Lieberman J, Zhou XZ, Song E, Lu KP. Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem-like cell traits in breast cancer. Cancer Research. 74: 3603-16. PMID 24786790 DOI: 10.1158/0008-5472.Can-13-2785  0.321
2014 Jalouli M, Déry MA, Lafleur VN, Lamalice L, Zhou XZ, Lu KP, Richard DE. The prolyl isomerase Pin1 regulates hypoxia-inducible transcription factor (HIF) activity. Cellular Signalling. 26: 1649-56. PMID 24726894 DOI: 10.1016/J.Cellsig.2014.04.005  0.369
2014 Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, ... ... Lu KP, et al. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature. 508: 541-5. PMID 24670654 DOI: 10.1038/Nature13079  0.405
2013 Chen CH, Chang CC, Lee TH, Luo M, Huang P, Liao PH, Wei S, Li FA, Chen RH, Zhou XZ, Shih HM, Lu KP. SENP1 deSUMOylates and regulates Pin1 protein activity and cellular function. Cancer Research. 73: 3951-62. PMID 23633483 DOI: 10.1158/0008-5472.Can-12-4360  0.412
2013 Toko H, Konstandin MH, Doroudgar S, Ormachea L, Joyo E, Joyo AY, Din S, Gude NA, Collins B, Völkers M, Thuerauf DJ, Glembotski CC, Chen CH, Lu KP, Müller OJ, et al. Regulation of cardiac hypertrophic signaling by prolyl isomerase Pin1. Circulation Research. 112: 1244-52. PMID 23487407 DOI: 10.1161/Circresaha.113.301084  0.333
2013 Nakamura K, Zhou XZ, Lu KP. Distinct functions of cis and trans phosphorylated tau in Alzheimer's disease and their therapeutic implications. Current Molecular Medicine. 13: 1098-109. PMID 23157676 DOI: 10.2174/1566524011313070001  0.429
2013 Frain L, Swanson D, Betensky R, Cho K, Gagnon D, Kowall N, Lu KP, Gaziano JM, Driver J. P3-175: A reduced risk of Alzheimer's disease is associated with the majority of cancers in a national cohort of veterans Alzheimer's & Dementia. 9: P617-P617. DOI: 10.1016/J.Jalz.2013.05.1247  0.314
2012 Keune WJ, Jones DR, Bultsma Y, Sommer L, Zhou XZ, Lu KP, Divecha N. Regulation of phosphatidylinositol-5-phosphate signaling by Pin1 determines sensitivity to oxidative stress. Science Signaling. 5: ra86. PMID 23193159 DOI: 10.1126/Scisignal.2003223  0.336
2012 De S, Greenwood AI, Rogals MJ, Kovrigin EL, Lu KP, Nicholson LK. Complete thermodynamic and kinetic characterization of the isomer-specific interaction between Pin1-WW domain and the amyloid precursor protein cytoplasmic tail phosphorylated at Thr668. Biochemistry. 51: 8583-96. PMID 23025283 DOI: 10.1021/Bi3008214  0.37
2012 Yoon SO, Park DJ, Ryu JC, Ozer HG, Tep C, Shin YJ, Lim TH, Pastorino L, Kunwar AJ, Walton JC, Nagahara AH, Lu KP, Nelson RJ, Tuszynski MH, Huang K. JNK3 perpetuates metabolic stress induced by Aβ peptides. Neuron. 75: 824-37. PMID 22958823 DOI: 10.1016/J.Neuron.2012.06.024  0.364
2012 Min SH, Lau AW, Lee TH, Inuzuka H, Wei S, Huang P, Shaik S, Lee DY, Finn G, Balastik M, Chen CH, Luo M, Tron AE, Decaprio JA, Zhou XZ, ... ... Lu KP, et al. Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase. Molecular Cell. 46: 771-83. PMID 22608923 DOI: 10.1016/J.Molcel.2012.04.012  0.371
2012 Rangasamy V, Mishra R, Sondarva G, Das S, Lee TH, Bakowska JC, Tzivion G, Malter JS, Rana B, Lu KP, Kanthasamy A, Rana A. Mixed-lineage kinase 3 phosphorylates prolyl-isomerase Pin1 to regulate its nuclear translocation and cellular function. Proceedings of the National Academy of Sciences of the United States of America. 109: 8149-54. PMID 22566623 DOI: 10.1073/Pnas.1200804109  0.42
2012 Nakamura K, Greenwood A, Binder L, Bigio EH, Denial S, Nicholson L, Zhou XZ, Lu KP. Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease. Cell. 149: 232-44. PMID 22464332 DOI: 10.1016/J.Cell.2012.02.016  0.443
2012 Pastorino L, Ma SL, Balastik M, Huang P, Pandya D, Nicholson L, Lu KP. Alzheimer's disease-related loss of Pin1 function influences the intracellular localization and the processing of AβPP. Journal of Alzheimer's Disease : Jad. 30: 277-97. PMID 22430533 DOI: 10.3233/Jad-2012-111259  0.388
2012 Wang J, Ray PS, Sim MS, Zhou XZ, Lu KP, Lee AV, Lin X, Bagaria SP, Giuliano AE, Cui X. FOXC1 regulates the functions of human basal-like breast cancer cells by activating NF-κB signaling. Oncogene. 31: 4798-802. PMID 22249250 DOI: 10.1038/Onc.2011.635  0.331
2012 Ma SL, Pastorino L, Zhou XZ, Lu KP. Prolyl isomerase Pin1 promotes amyloid precursor protein (APP) turnover by inhibiting glycogen synthase kinase-3β (GSK3β) activity: novel mechanism for Pin1 to protect against Alzheimer disease. The Journal of Biological Chemistry. 287: 6969-73. PMID 22184106 DOI: 10.1074/Jbc.C111.298596  0.418
2012 Rajbhandari P, Finn G, Solodin NM, Singarapu KK, Sahu SC, Markley JL, Kadunc KJ, Ellison-Zelski SJ, Kariagina A, Haslam SZ, Lu KP, Alarid ET. Regulation of estrogen receptor α N-terminus conformation and function by peptidyl prolyl isomerase Pin1. Molecular and Cellular Biology. 32: 445-57. PMID 22064478 DOI: 10.1128/Mcb.06073-11  0.377
2012 Ma SL, Tang NL, Tam CW, Lui VW, Lam LC, Chiu HF, Driver JA, Pastorino L, Lu KP. A PIN1 polymorphism that prevents its suppression by AP4 associates with delayed onset of Alzheimer's disease. Neurobiology of Aging. 33: 804-13. PMID 20580132 DOI: 10.1016/J.Neurobiolaging.2010.05.018  0.361
2011 Greenwood AI, Rogals MJ, De S, Lu KP, Kovrigin EL, Nicholson LK. Complete determination of the Pin1 catalytic domain thermodynamic cycle by NMR lineshape analysis. Journal of Biomolecular Nmr. 51: 21-34. PMID 21947912 DOI: 10.1007/S10858-011-9538-9  0.321
2011 Liou YC, Zhou XZ, Lu KP. Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins. Trends in Biochemical Sciences. 36: 501-14. PMID 21852138 DOI: 10.1016/J.Tibs.2011.07.001  0.377
2011 Yuan WC, Lee YR, Huang SF, Lin YM, Chen TY, Chung HC, Tsai CH, Chen HY, Chiang CT, Lai CK, Lu LT, Chen CH, Gu DL, Pu YS, Jou YS, ... Lu KP, et al. A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression. Cancer Cell. 20: 214-28. PMID 21840486 DOI: 10.1016/J.Ccr.2011.07.008  0.322
2011 Lee TH, Pastorino L, Lu KP. Peptidyl-prolyl cis-trans isomerase Pin1 in ageing, cancer and Alzheimer disease. Expert Reviews in Molecular Medicine. 13: e21. PMID 21682951 DOI: 10.1017/S1462399411001906  0.432
2011 Lee TH, Chen CH, Suizu F, Huang P, Schiene-Fischer C, Daum S, Zhang YJ, Goate A, Chen RH, Zhou XZ, Lu KP. Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function. Molecular Cell. 42: 147-59. PMID 21497122 DOI: 10.1016/J.Molcel.2011.03.005  0.421
2011 Zhou XZ, Huang P, Shi R, Lee TH, Lu G, Zhang Z, Bronson R, Lu KP. The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice. The Journal of Clinical Investigation. 121: 1266-82. PMID 21436583 DOI: 10.1172/Jci43452  0.325
2011 Soohoo CY, Shi R, Lee TH, Huang P, Lu KP, Zhou XZ. Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongation. The Journal of Biological Chemistry. 286: 3894-906. PMID 21119197 DOI: 10.1074/Jbc.M110.180174  0.33
2011 Lee TH, Chen C, Zhou XZ, Lu KP. Abstract 919: Death associated protein kinase 1 phosphoylates Pin1 and inhibits its cellular function Cancer Research. 71: 919-919. DOI: 10.1158/1538-7445.Am2011-919  0.444
2010 Driver JA, Lu KP. Pin1: a new genetic link between Alzheimer's disease, cancer and aging. Current Aging Science. 3: 158-65. PMID 20735350 DOI: 10.2174/1874609811003030158  0.429
2010 Lee TH, Zhou XZ, Lu KP. Abstract 1009: Critical role of Pin1 for the regulation of TRF1 stability and ubiquitination Cancer Research. 70: 1009-1009. DOI: 10.1158/1538-7445.Am10-1009  0.443
2010 Lu KP, Patorino L, Ma SL, Nakamura K, Driver J, Zhou XZ. O4-04-01: Pin1 protects against tau and Abeta-related pathologies and delays onset of Alzheimer's disease Alzheimer's & Dementia. 6: S154-S155. DOI: 10.1016/J.Jalz.2010.05.481  0.31
2009 Fan G, Fan Y, Gupta N, Matsuura I, Liu F, Zhou XZ, Lu KP, Gélinas C. Peptidyl-prolyl isomerase Pin1 markedly enhances the oncogenic activity of the rel proteins in the nuclear factor-kappaB family. Cancer Research. 69: 4589-97. PMID 19458071 DOI: 10.1158/0008-5472.Can-08-4117  0.322
2009 Ryo A, Wulf G, Lee TH, Lu KP. Pinning down HER2-ER crosstalk in SMRT regulation. Trends in Biochemical Sciences. 34: 162-5. PMID 19269830 DOI: 10.1016/J.Tibs.2008.12.004  0.307
2009 Lee TH, Tun-Kyi A, Shi R, Lim J, Soohoo C, Finn G, Balastik M, Pastorino L, Wulf G, Zhou XZ, Lu KP. Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance. Nature Cell Biology. 11: 97-105. PMID 19060891 DOI: 10.1038/Ncb1818  0.31
2008 Lam PB, Burga LN, Wu BP, Hofstatter EW, Lu KP, Wulf GM. Prolyl isomerase Pin1 is highly expressed in Her2-positive breast cancer and regulates erbB2 protein stability. Molecular Cancer. 7: 91. PMID 19077306 DOI: 10.1186/1476-4598-7-91  0.339
2008 Finn G, Lu KP. Phosphorylation-specific prolyl isomerase Pin1 as a new diagnostic and therapeutic target for cancer. Current Cancer Drug Targets. 8: 223-9. PMID 18473735 DOI: 10.2174/156800908784293622  0.44
2008 Cole AR, Soutar MP, Rembutsu M, van Aalten L, Hastie CJ, McLauchlan H, Peggie M, Balastik M, Lu KP, Sutherland C. Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation. The Journal of Biological Chemistry. 283: 18227-37. PMID 18460467 DOI: 10.1074/Jbc.M801645200  0.408
2008 Lim J, Balastik M, Lee TH, Nakamura K, Liou YC, Sun A, Finn G, Pastorino L, Lee VM, Lu KP. Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy. The Journal of Clinical Investigation. 118: 1877-89. PMID 18431510 DOI: 10.1172/Jci34308  0.389
2007 Wildemann D, Hernandez Alvarez B, Stoller G, Zhou XZ, Lu KP, Erdmann F, Ferrari D, Fischer G. An essential role for Pin1 in Xenopus laevis embryonic development revealed by specific inhibitors. Biological Chemistry. 388: 1103-11. PMID 17937625 DOI: 10.1515/Bc.2007.127  0.36
2007 Lu KP, Zhou XZ. The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease. Nature Reviews. Molecular Cell Biology. 8: 904-16. PMID 17878917 DOI: 10.1038/Nrm2261  0.427
2007 Lu KP, Finn G, Lee TH, Nicholson LK. Prolyl cis-trans isomerization as a molecular timer. Nature Chemical Biology. 3: 619-29. PMID 17876319 DOI: 10.1038/Nchembio.2007.35  0.366
2007 Li QM, Tep C, Yune TY, Zhou XZ, Uchida T, Lu KP, Yoon SO. Opposite regulation of oligodendrocyte apoptosis by JNK3 and Pin1 after spinal cord injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 8395-404. PMID 17670986 DOI: 10.1523/Jneurosci.2478-07.2007  0.335
2007 Zhang Y, Daum S, Wildemann D, Zhou XZ, Verdecia MA, Bowman ME, Lücke C, Hunter T, Lu KP, Fischer G, Noel JP. Structural basis for high-affinity peptide inhibition of human Pin1. Acs Chemical Biology. 2: 320-8. PMID 17518432 DOI: 10.1021/Cb7000044  0.458
2007 Nicholson LK, Lu KP. Prolyl cis-trans Isomerization as a molecular timer in Crk signaling. Molecular Cell. 25: 483-5. PMID 17317620 DOI: 10.1016/J.Molcel.2007.02.005  0.323
2007 Balastik M, Lim J, Pastorino L, Lu KP. Pin1 in Alzheimer's disease: multiple substrates, one regulatory mechanism? Biochimica Et Biophysica Acta. 1772: 422-9. PMID 17317113 DOI: 10.1016/J.Bbadis.2007.01.006  0.445
2006 Pastorino L, Lu KP. Pathogenic mechanisms in Alzheimer's disease. European Journal of Pharmacology. 545: 29-38. PMID 16904664 DOI: 10.1016/J.Ejphar.2006.06.078  0.321
2006 Lu KP, Suizu F, Zhou XZ, Finn G, Lam P, Wulf G. Targeting carcinogenesis: a role for the prolyl isomerase Pin1? Molecular Carcinogenesis. 45: 397-402. PMID 16652378 DOI: 10.1002/Mc.20216  0.447
2006 Yu L, Mohamed AJ, Vargas L, Berglöf A, Finn G, Lu KP, Smith CI. Regulation of Bruton tyrosine kinase by the peptidylprolyl isomerase Pin1. The Journal of Biological Chemistry. 281: 18201-7. PMID 16644721 DOI: 10.1074/Jbc.M603090200  0.427
2006 Pastorino L, Sun A, Lu PJ, Zhou XZ, Balastik M, Finn G, Wulf G, Lim J, Li SH, Li X, Xia W, Nicholson LK, Lu KP. The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production. Nature. 440: 528-34. PMID 16554819 DOI: 10.1038/Nature04543  0.394
2006 Suizu F, Ryo A, Wulf G, Lim J, Lu KP. Pin1 regulates centrosome duplication, and its overexpression induces centrosome amplification, chromosome instability, and oncogenesis. Molecular and Cellular Biology. 26: 1463-79. PMID 16449657 DOI: 10.1128/Mcb.26.4.1463-1479.2006  0.416
2006 Lee TH, Perrem K, Harper JW, Lu KP, Zhou XZ. The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance. The Journal of Biological Chemistry. 281: 759-68. PMID 16275645 DOI: 10.1074/Jbc.M509855200  0.39
2006 Sultana R, Boyd-Kimball D, Poon HF, Cai J, Pierce WM, Klein JB, Markesbery WR, Zhou XZ, Lu KP, Butterfield DA. Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis. Neurobiology of Aging. 27: 918-25. PMID 15950321 DOI: 10.1016/J.Neurobiolaging.2005.05.005  0.333
2005 Wulf G, Finn G, Suizu F, Lu KP. Phosphorylation-specific prolyl isomerization: is there an underlying theme? Nature Cell Biology. 7: 435-41. PMID 15867923 DOI: 10.1038/Ncb0505-435  0.403
2005 Dougherty MK, Müller J, Ritt DA, Zhou M, Zhou XZ, Copeland TD, Conrads TP, Veenstra TD, Lu KP, Morrison DK. Regulation of Raf-1 by direct feedback phosphorylation. Molecular Cell. 17: 215-24. PMID 15664191 DOI: 10.1016/J.Molcel.2004.11.055  0.355
2005 Lim J, Lu KP. Pinning down phosphorylated tau and tauopathies. Biochimica Et Biophysica Acta. 1739: 311-22. PMID 15615648 DOI: 10.1016/J.Bbadis.2004.10.003  0.444
2004 Wulf G, Garg P, Liou YC, Iglehart D, Lu KP. Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis. The Embo Journal. 23: 3397-407. PMID 15257284 DOI: 10.1038/Sj.Emboj.7600323  0.377
2004 Kim KT, Ongusaha PP, Hong YK, Kurdistani SK, Nakamura M, Lu KP, Lee SW. Function of Drg1/Rit42 in p53-dependent mitotic spindle checkpoint. The Journal of Biological Chemistry. 279: 38597-602. PMID 15247272 DOI: 10.1074/Jbc.M400781200  0.352
2004 Bao L, Kimzey A, Sauter G, Sowadski JM, Lu KP, Wang DG. Prevalent overexpression of prolyl isomerase Pin1 in human cancers. The American Journal of Pathology. 164: 1727-37. PMID 15111319 DOI: 10.1016/S0002-9440(10)63731-5  0.375
2004 Lu KP. Pinning down cell signaling, cancer and Alzheimer's disease. Trends in Biochemical Sciences. 29: 200-9. PMID 15082314 DOI: 10.1016/J.Tibs.2004.02.002  0.417
2004 Pastorino L, Lu KP. Phosphorylation of the amyloid precursor protein (APP): Is this a mechanism in favor or against Alzheimer's disease? Neuroscience Research Communications. 35: 213-231. DOI: 10.1002/Nrc.20035  0.386
2003 Ryo A, Suizu F, Yoshida Y, Perrem K, Liou YC, Wulf G, Rottapel R, Yamaoka S, Lu KP. Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Molecular Cell. 12: 1413-26. PMID 14690596 DOI: 10.1016/S1097-2765(03)00490-8  0.333
2003 Xu YX, Hirose Y, Zhou XZ, Lu KP, Manley JL. Pin1 modulates the structure and function of human RNA polymerase II. Genes & Development. 17: 2765-76. PMID 14600023 DOI: 10.1101/Gad.1135503  0.333
2003 Liou YC, Sun A, Ryo A, Zhou XZ, Yu ZX, Huang HK, Uchida T, Bronson R, Bing G, Li X, Hunter T, Lu KP. Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature. 424: 556-61. PMID 12891359 DOI: 10.1038/Nature01832  0.557
2003 Zhou XZ, Perrem K, Lu KP. Role of Pin2/TRF1 in telomere maintenance and cell cycle control. Journal of Cellular Biochemistry. 89: 19-37. PMID 12682905 DOI: 10.1002/Jcb.10496  0.352
2003 Wulf G, Ryo A, Liou YC, Lu KP. The prolyl isomerase Pin1 in breast development and cancer. Breast Cancer Research : Bcr. 5: 76-82. PMID 12631385 DOI: 10.1186/Bcr572  0.318
2003 Ryo A, Liou YC, Lu KP, Wulf G. Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer. Journal of Cell Science. 116: 773-83. PMID 12571275 DOI: 10.1242/Jcs.00276  0.438
2003 Lu KP, Liou YC, Vincent I. Proline-directed phosphorylation and isomerization in mitotic regulation and in Alzheimer's Disease. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 25: 174-81. PMID 12539244 DOI: 10.1002/Bies.10223  0.438
2002 Zheng H, You H, Zhou XZ, Murray SA, Uchida T, Wulf G, Gu L, Tang X, Lu KP, Xiao ZX. The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response. Nature. 419: 849-53. PMID 12397361 DOI: 10.1038/Nature01116  0.349
2002 Wulf GM, Liou YC, Ryo A, Lee SW, Lu KP. Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage. The Journal of Biological Chemistry. 277: 47976-9. PMID 12388558 DOI: 10.1074/Jbc.C200538200  0.363
2002 Ryo A, Liou YC, Wulf G, Nakamura M, Lee SW, Lu KP. PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells. Molecular and Cellular Biology. 22: 5281-95. PMID 12101225 DOI: 10.1128/Mcb.22.15.5281-5295.2002  0.366
2002 Lu KP, Liou YC, Zhou XZ. Pinning down proline-directed phosphorylation signaling. Trends in Cell Biology. 12: 164-72. PMID 11978535 DOI: 10.1016/S0962-8924(02)02253-5  0.422
2002 Nakamura M, Zhou XZ, Kishi S, Lu KP. Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle. Febs Letters. 514: 193-8. PMID 11943150 DOI: 10.1016/S0014-5793(02)02363-3  0.4
2002 Kops O, Zhou XZ, Lu KP. Pin1 modulates the dephosphorylation of the RNA polymerase II C-terminal domain by yeast Fcp1. Febs Letters. 513: 305-11. PMID 11904169 DOI: 10.1016/S0014-5793(02)02288-3  0.375
2002 Liou YC, Ryo A, Huang HK, Lu PJ, Bronson R, Fujimori F, Uchida T, Hunter T, Lu KP. Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes. Proceedings of the National Academy of Sciences of the United States of America. 99: 1335-40. PMID 11805292 DOI: 10.1073/Pnas.032404099  0.502
2002 Kishi S, Lu KP. A critical role for Pin2/TRF1 in ATM-dependent regulation. Inhibition of Pin2/TRF1 function complements telomere shortening, radiosensitivity, and the G(2)/M checkpoint defect of ataxia-telangiectasia cells. The Journal of Biological Chemistry. 277: 7420-9. PMID 11744712 DOI: 10.1074/Jbc.M111365200  0.337
2002 Lu PJ, Zhou XZ, Liou YC, Noel JP, Lu KP. Critical role of WW domain phosphorylation in regulating phosphoserine binding activity and Pin1 function. The Journal of Biological Chemistry. 277: 2381-4. PMID 11723108 DOI: 10.1074/Jbc.C100228200  0.386
2001 Zhou XZ, Lu KP. The Pin2/TRF1-Interacting Protein PinX1 Is a Potent Telomerase Inhibitor Cell. 107: 347-359. PMID 11701125 DOI: 10.1016/S0092-8674(01)00538-4  0.344
2001 Nakamura M, Zhou XZ, Kishi S, Kosugi I, Tsutsui Y, Lu KP. A specific interaction between the telomeric protein Pin2/TRF1 and the mitotic spindle. Current Biology. 11: 1512-1516. PMID 11591318 DOI: 10.1016/S0960-9822(01)00456-0  0.396
2001 Nakamura M, Zhou XZ, Lu KP. Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization. Current Biology. 11: 1062-1067. PMID 11470413 DOI: 10.1016/S0960-9822(01)00297-4  0.36
2001 Wulf GM, Ryo A, Wulf GG, Lee SW, Niu T, Petkova V, Lu KP. Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1 The Embo Journal. 20: 3459-3472. PMID 11432833 DOI: 10.1093/Emboj/20.13.3459  0.36
2001 Kishi S, Zhou XZ, Ziv Y, Khoo C, Hill DE, Shiloh Y, Lu KP. Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks. The Journal of Biological Chemistry. 276: 29282-91. PMID 11375976 DOI: 10.1074/Jbc.M011534200  0.37
2001 Liu W, Youn HD, Zhou XZ, Lu KP, Liu JO. Binding and regulation of the transcription factor NFAT by the peptidyl prolyl cis-trans isomerase Pin1 Febs Letters. 496: 105-108. PMID 11356192 DOI: 10.1016/S0014-5793(01)02411-5  0.375
2001 Kishi S, Wulf G, Nakamura M, Lu KP. Telomeric protein Pin2/TRF1 induces mitotic entry and apoptosis in cells with short telomeres and is down-regulated in human breast tumors. Oncogene. 20: 1497-1508. PMID 11313893 DOI: 10.1038/Sj.Onc.1204229  0.358
2000 Yao JL, Kops O, Lu PJ, Lu KP. Functional conservation of phosphorylation-specific prolyl isomerases in plants. The Journal of Biological Chemistry. 276: 13517-23. PMID 11118438 DOI: 10.1074/Jbc.M007006200  0.34
2000 Zhou XZ, Kops O, Werner A, Lu PJ, Shen M, Stoller G, Küllertz G, Stark M, Fischer G, Lu KP. Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins. Molecular Cell. 6: 873-883. PMID 11090625 DOI: 10.1016/S1097-2765(05)00083-3  0.454
2000 Verdecia MA, Bowman ME, Lu KP, Hunter T, Noel JP. Structural basis for phosphoserine-proline recognition by group IV WW domains. Nature Structural Biology. 7: 639-43. PMID 10932246 DOI: 10.1038/77929  0.47
2000 Lee SW, Fang L, Igarashi M, Ouchi T, Lu KP, Aaronson SA. Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53. Proceedings of the National Academy of Sciences of the United States of America. 97: 8302-5. PMID 10890907 DOI: 10.1073/Pnas.150024397  0.352
2000 Lu KP. Phosphorylation-dependent prolyl isomerization: a novel cell cycle regulatory mechanism Progress in Cell Cycle Research. 4: 83-96. PMID 10740817 DOI: 10.1007/978-1-4615-4253-7_8  0.409
1999 Zhou XZ, Lu P-, Wulf G, Lu KP. Phosphorylation-dependent prolyl isomerization: A novel signaling regulatory mechanism Cellular and Molecular Life Sciences. 56: 788-806. PMID 11212339 DOI: 10.1007/S000180050026  0.464
1999 Mounsey JP, Lu KP, Patel MK, Chen ZH, Horne LT, John JE, Means AR, Jones LR, Moorman JR. Modulation of Xenopus oocyte-expressed phospholemman-induced ion currents by co-expression of protein kinases. Biochimica Et Biophysica Acta. 1451: 305-18. PMID 10556585 DOI: 10.1016/S0167-4889(99)00102-0  0.356
1999 Lu PJ, Wulf G, Zhou XZ, Davies P, Lu KP. The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein. Nature. 399: 784-8. PMID 10391244 DOI: 10.1038/21650  0.437
1999 Lu P, Zhou XZ, Shen M, Lu KP. Function of WW domains as phosphoserine- or phosphothreonine-binding modules. Science. 283: 1325-1328. PMID 10037602 DOI: 10.1126/Science.283.5406.1325  0.331
1998 Lu KP, Hunter T. The NIMA kinase: a mitotic regulator in Aspergillus nidulans and vertebrate cells. Progress in Cell Cycle Research. 1: 187-205. PMID 9552363 DOI: 10.1007/978-1-4615-1809-9_15  0.522
1998 Schutkowski M, Bernhardt A, Zhou XZ, Shen M, Reimer U, Rahfeld J, Lu KP, Fischer G. Role Of Phosphorylation In Determining The Backbone Dynamics Of The Serine/ Threonine-Proline Motif And Pin1 Substrate Recognition Biochemistry. 37: 5566-5575. PMID 9548941 DOI: 10.1021/Bi973060Z  0.399
1998 Shen M, Stukenberg PT, Kirschner MW, Lu KP. The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins. Genes & Development. 12: 706-20. PMID 9499405 DOI: 10.1101/Gad.12.5.706  0.422
1998 Shen M, Haggblom C, Vogt M, Hunter T, Lu KP. Characterization and cell cycle regulation of the related human telomeric proteins Pin2 and TRF1 suggest a role in mitosis. Proceedings of the National Academy of Sciences of the United States of America. 94: 13618-23. PMID 9391075 DOI: 10.1073/Pnas.94.25.13618  0.512
1997 Yaffe MB, Schutkowski M, Shen M, Zhou XZ, Stukenberg PT, Rahfeld JU, Xu J, Kuang J, Kirschner MW, Fischer G, Cantley LC, Lu KP. Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science (New York, N.Y.). 278: 1957-60. PMID 9395400 DOI: 10.1126/Science.278.5345.1957  0.387
1997 Ranganathan R, Lu KP, Hunter T, Noel JP. Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent. Cell. 89: 875-86. PMID 9200606 DOI: 10.1016/S0092-8674(00)80273-1  0.512
1996 Songyang Z, Lu KP, Kwon YT, Tsai LH, Filhol O, Cochet C, Brickey DA, Soderling TR, Bartleson C, Graves DJ, DeMaggio AJ, Hoekstra MF, Blenis J, Hunter T, Cantley LC. A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1. Molecular and Cellular Biology. 16: 6486-93. PMID 8887677 DOI: 10.1128/Mcb.16.11.6486  0.488
1996 Lu KP, Hanes SD, Hunter T. A human peptidyl-prolyl isomerase essential for regulation of mitosis. Nature. 380: 544-7. PMID 8606777 DOI: 10.1038/380544A0  0.535
1995 Lu KP, Hunter T. Evidence for a NIMA-like mitotic pathway in vertebrate cells. Cell. 81: 413-24. PMID 7736593 DOI: 10.1016/0092-8674(95)90394-1  0.506
1995 Lu KP, Nanthakumar NN, Dayton JS, Means AR. Calcium and Calmodulin Regulation of the Nuclear Division Cycle of Aspergillus Nidulans Advances in Molecular and Cell Biology. 13: 89-136. DOI: 10.1016/S1569-2558(08)60008-9  0.317
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