Sandra L. Siedlak, BS, Ohio University - Publications

Pathology Case Western Reserve University, Cleveland Heights, OH, United States 
Alzheimer disease

123 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Han S, Nandy P, Austria Q, Siedlak SL, Torres S, Fujioka H, Wang W, Zhu X. Mfn2 Ablation in the Adult Mouse Hippocampus and Cortex Causes Neuronal Death. Cells. 9. PMID 31947766 DOI: 10.3390/cells9010116  1
2018 Zhao F, Siedlak SL, Torres SL, Xu Q, Tang B, Zhu X. Conditional Haploinsufficiency of β-Catenin Aggravates Neuronal Damage in a Paraquat-Based Mouse Model of Parkinson Disease. Molecular Neurobiology. PMID 30519817 DOI: 10.1007/s12035-018-1431-z  1
2018 Wang C, Zhao F, Shen K, Wang W, Siedlak SL, Lee HG, Phelix CF, Perry G, Shen L, Tang B, Yan R, Zhu X. The sterol regulatory element-binding protein 2 is likely dysregulated by tau alterations in Alzheimer disease. Brain Pathology (Zurich, Switzerland). PMID 30515907 DOI: 10.1111/bpa.12691  1
2018 Wang L, Gao J, Liu J, Siedlak SL, Torres S, Fujioka H, Huntley ML, Jiang Y, Ji H, Yan T, Harland M, Termsarasab P, Zeng S, Jiang Z, Liang J, et al. Mitofusin 2 Regulates Axonal Transport of Calpastatin to Prevent Neuromuscular Synaptic Elimination in Skeletal Muscles. Cell Metabolism. PMID 30017354 DOI: 10.1016/j.cmet.2018.06.011  1
2018 Yan T, Wang L, Gao J, Siedlak SL, Huntley ML, Termsarasab P, Perry G, Chen SG, Wang X. Rab10 Phosphorylation is a Prominent Pathological Feature in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 29562525 DOI: 10.3233/JAD-180023  1
2018 Jiang S, Nandy P, Wang W, Ma X, Hsia J, Wang C, Wang Z, Niu M, Siedlak SL, Torres S, Fujioka H, Xu Y, Lee HG, Perry G, Liu J, et al. Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex. Molecular Neurodegeneration. 13: 5. PMID 29391029 DOI: 10.1186/s13024-018-0238-8  1
2017 Wang W, Yin J, Ma X, Zhao F, Siedlak SL, Wang Z, Fujioka H, Xu Y, Perry G, Zhu X. Inhibition of mitochondrial fragmentation protects against Alzheimer's disease in rodent model. Human Molecular Genetics. PMID 28973308 DOI: 10.1093/hmg/ddx299  1
2017 Siedlak SL, Jiang Y, Huntley ML, Wang L, Gao J, Xie F, Liu J, Su B, Perry G, Wang X. TMEM230 Accumulation in Granulovacuolar Degeneration Bodies and Dystrophic Neurites of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 28527219 DOI: 10.3233/JAD-170190  1
2017 Zhao F, Wang W, Wang C, Siedlak SL, Fujioka H, Tang B, Zhu X. Mfn2 Protects Dopaminergic Neurons Exposed to Paraquat Both in vitro and in vivo: Implications for Idiopathic Parkinson's Disease. Biochimica Et Biophysica Acta. PMID 28215578 DOI: 10.1016/j.bbadis.2017.02.016  1
2017 Wang W, Arakawa H, Wang L, Okolo O, Siedlak SL, Jiang Y, Gao J, Xie F, Petersen RB, Wang X. Motor-Coordinative and Cognitive Dysfunction Caused by Mutant TDP-43 Could Be Reversed by Inhibiting Its Mitochondrial Localization. Molecular Therapy : the Journal of the American Society of Gene Therapy. 25: 127-139. PMID 28129109 DOI: 10.1016/j.ymthe.2016.10.013  0.92
2016 Gore E, Appleby BS, Cohen ML, DeBrosse SD, Leverenz JB, Miller BL, Siedlak SL, Zhu X, Lerner AJ. Clinical and imaging characteristics of late onset mitochondrial membrane protein-associated neurodegeneration (MPAN). Neurocase. 1-8. PMID 27801611 DOI: 10.1080/13554794.2016.1247458  1
2016 Wang W, Wang L, Lu J, Siedlak SL, Fujioka H, Liang J, Jiang S, Ma X, Jiang Z, da Rocha EL, Sheng M, Choi H, Lerou PH, Li H, Wang X. The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity. Nature Medicine. PMID 27348499 DOI: 10.1038/nm.4130  1
2016 Blair JA, Wang C, Hernandez D, Siedlak SL, Rodgers MS, Achar RK, Fahmy LM, Torres SL, Petersen RB, Zhu X, Casadesus G, Lee HG. Correction: Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation. Plos One. 11: e0157209. PMID 27258001 DOI: 10.1371/journal.pone.0157209  1
2016 Gorelenkova Miller O, Behring JB, Siedlak SL, Jiang S, Matsui R, Bachschmid MM, Zhu X, Mieyal JJ. Upregulation of Glutaredoxin-1 Activates Microglia and Promotes Neurodegeneration: Implications for Parkinson's disease. Antioxidants & Redox Signaling. PMID 27224303 DOI: 10.1089/ars.2015.6598  1
2016 Blair JA, Wang C, Hernandez D, Siedlak SL, Rodgers MS, Achar RK, Fahmy LM, Torres SL, Petersen RB, Zhu X, Casadesus G, Lee HG. Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation. Plos One. 11: e0151615. PMID 26982086 DOI: 10.1371/journal.pone.0151615  1
2016 Wang C, Zhang F, Jiang S, Siedlak SL, Shen L, Perry G, Wang X, Tang B, Zhu X. Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer's disease. Scientific Reports. 6: 20352. PMID 26837465 DOI: 10.1038/srep20352  1
2015 Zhang F, Wang W, Siedlak SL, Liu Y, Liu J, Jiang K, Perry G, Zhu X, Wang X. Miro1 deficiency in amyotrophic lateral sclerosis. Frontiers in Aging Neuroscience. 7: 100. PMID 26074815 DOI: 10.3389/fnagi.2015.00100  1
2015 Zhang F, Su B, Wang C, Siedlak SL, Mondragon-Rodriguez S, Lee HG, Wang X, Perry G, Zhu X. Posttranslational modifications of α-tubulin in alzheimer disease. Translational Neurodegeneration. 4: 9. PMID 26029362 DOI: 10.1186/s40035-015-0030-4  1
2015 Ngo J, Matsuyama M, Kim C, Poventud-Fuentes I, Bates A, Siedlak SL, Lee HG, Doughman YQ, Watanabe M, Liner A, Hoit B, Voelkel N, Gerson S, Hasty P, Matsuyama S. Bax deficiency extends the survival of Ku70 knockout mice that develop lung and heart diseases. Cell Death & Disease. 6: e1706. PMID 25811803 DOI: 10.1038/cddis.2015.11  1
2015 Wang W, Zhang F, Li L, Tang F, Siedlak SL, Fujioka H, Liu Y, Su B, Pi Y, Wang X. MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons. The Journal of Biological Chemistry. 290: 168-82. PMID 25416777 DOI: 10.1074/jbc.M114.617167  1
2015 Johnson WM, Yao C, Siedlak SL, Wang W, Zhu X, Caldwell GA, Wilson-Delfosse AL, Mieyal JJ, Chen SG. Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease. Human Molecular Genetics. 24: 1322-35. PMID 25355420 DOI: 10.1093/hmg/ddu542  1
2015 Hradek AC, Lee HP, Siedlak SL, Torres SL, Jung W, Han AH, Lee HG. Distinct chronology of neuronal cell cycle re-entry and tau pathology in the 3xTg-AD mouse model and Alzheimer's disease patients. Journal of Alzheimer's Disease : Jad. 43: 57-65. PMID 25061053 DOI: 10.3233/JAD-141083  1
2014 Blair JA, Siedlak SL, Wolfram JA, Nunomura A, Castellani RJ, Ferreira ST, Klein WL, Wang Y, Casadesus G, Smith MA, Perry G, Zhu X, Lee HG. Accumulation of intraneuronal amyloid-β is common in normal brain. Current Alzheimer Research. 11: 317-24. PMID 24597504 DOI: 10.2174/1567205011666140302200902  1
2014 Bonda DJ, Stone JG, Torres SL, Siedlak SL, Perry G, Kryscio R, Jicha G, Casadesus G, Smith MA, Zhu X, Lee HG. Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance. Journal of Neurochemistry. 128: 162-72. PMID 23895348 DOI: 10.1111/jnc.12380  1
2013 Williams WM, Torres S, Siedlak SL, Castellani RJ, Perry G, Smith MA, Zhu X. Antimicrobial peptide β-defensin-1 expression is upregulated in Alzheimer's brain. Journal of Neuroinflammation. 10: 127. PMID 24139179 DOI: 10.1186/1742-2094-10-127  1
2013 Zivković L, Spremo-Potparević B, Siedlak SL, Perry G, PlećaÅ¡-Solarović B, Milićević Z, Bajić VP. DNA damage in Alzheimer disease lymphocytes and its relation to premature centromere division. Neuro-Degenerative Diseases. 12: 156-63. PMID 23406622 DOI: 10.1159/000346114  1
2012 Liu K, Guo TL, Chojnacki J, Lee HG, Wang X, Siedlak SL, Rao W, Zhu X, Zhang S. Bivalent ligand containing curcumin and cholesterol as fluorescence probe for Aβ plaques in Alzheimer's disease. Acs Chemical Neuroscience. 3: 141-146. PMID 22685625 DOI: 10.1021/cn200122j  1
2012 Zhu X, Castellani RJ, Moreira PI, Aliev G, Shenk JC, Siedlak SL, Harris PL, Fujioka H, Sayre LM, Szweda PA, Szweda LI, Smith MA, Perry G. Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover. Free Radical Biology & Medicine. 52: 699-704. PMID 22137893 DOI: 10.1016/j.freeradbiomed.2011.11.004  1
2011 Castellani RJ, Gupta Y, Sheng B, Siedlak SL, Harris PL, Coller JM, Perry G, Lee HG, Tabaton M, Smith MA, Wang X, Zhu X. A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules. Laboratory Investigation; a Journal of Technical Methods and Pathology. 91: 1777-86. PMID 21968813 DOI: 10.1038/labinvest.2011.149  1
2011 Stone JG, Casadesus G, Gustaw-Rothenberg K, Siedlak SL, Wang X, Zhu X, Perry G, Castellani RJ, Smith MA. Frontiers in Alzheimer's disease therapeutics. Therapeutic Advances in Chronic Disease. 2: 9-23. PMID 21743833 DOI: 10.1177/2040622310382817  1
2011 Stone JG, Siedlak SL, Tabaton M, Hirano A, Castellani RJ, Santocanale C, Perry G, Smith MA, Zhu X, Lee HG. The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies. Journal of Neuropathology and Experimental Neurology. 70: 578-87. PMID 21666500 DOI: 10.1097/NEN.0b013e3182204414  1
2011 Bajić VP, Su B, Lee HG, Kudo W, Siedlak SL, Zivković L, Spremo-Potparević B, Djelic N, Milicevic Z, Singh AK, Fahmy LM, Wang X, Smith MA, Zhu X. Mislocalization of CDK11/PITSLRE, a regulator of the G2/M phase of the cell cycle, in Alzheimer disease. Cellular & Molecular Biology Letters. 16: 359-72. PMID 21461981 DOI: 10.2478/s11658-011-0011-2  1
2011 Hoffman WH, Siedlak SL, Wang Y, Castellani RJ, Smith MA. Oxidative damage is present in the fatal brain edema of diabetic ketoacidosis. Brain Research. 1369: 194-202. PMID 21040714 DOI: 10.1016/j.brainres.2010.10.085  1
2011 Rothenberg KG, Siedlak SL, Lee HG, Zhu X, Perry G, Smith MA. Neurodegenerative processes in Alzheimer's disease: An overview of pathogenesis with strategic biomarker potential Future Neurology. 6: 173-185. DOI: 10.2217/fnl.10.81  1
2010 Zivković L, Spremo-Potparević B, Plecas-Solarović B, Djelić N, Ocić G, Smiljković P, Siedlak SL, Smith MA, Bajić V. Premature centromere division of metaphase chromosomes in peripheral blood lymphocytes of Alzheimer's disease patients: relation to gender and age. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 65: 1269-74. PMID 20805239 DOI: 10.1093/gerona/glq148  1
2010 Buxton GA, Siedlak SL, Perry G, Smith MA. Mathematical modeling of microtubule dynamics: insights into physiology and disease. Progress in Neurobiology. 92: 478-83. PMID 20713128 DOI: 10.1016/j.pneurobio.2010.08.003  1
2010 Bonda DJ, Mailankot M, Stone JG, Garrett MR, Staniszewska M, Castellani RJ, Siedlak SL, Zhu X, Lee HG, Perry G, Nagaraj RH, Smith MA. Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease. Redox Report : Communications in Free Radical Research. 15: 161-8. PMID 20663292 DOI: 10.1179/174329210X12650506623645  1
2010 Moh CF, Siedlak SL, Tabaton M, Perry G, Castellani RJ, Smith MA. Paraffin-embedded tissue (PET) blot method: application to Alzheimer disease. Journal of Neuroscience Methods. 190: 244-7. PMID 20580647 DOI: 10.1016/j.jneumeth.2010.05.010  1
2010 Poeggeler B, Sambamurti K, Siedlak SL, Perry G, Smith MA, Pappolla MA. A novel endogenous indole protects rodent mitochondria and extends rotifer lifespan. Plos One. 5: e10206. PMID 20421998 DOI: 10.1371/journal.pone.0010206  1
2010 Heath JE, Siedlak SL, Zhu X, Lee HG, Thakur A, Yan R, Perry G, Smith MA, Castellani RJ. Widespread distribution of reticulon-3 in various neurodegenerative diseases. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 30: 574-9. PMID 20374499 DOI: 10.1111/j.1440-1789.2010.01107.x  1
2010 Smith MA, Zhu X, Tabaton M, Liu G, McKeel DW, Cohen ML, Wang X, Siedlak SL, Dwyer BE, Hayashi T, Nakamura M, Nunomura A, Perry G. Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment. Journal of Alzheimer's Disease : Jad. 19: 363-72. PMID 20061651 DOI: 10.3233/JAD-2010-1239  1
2010 Gustaw-Rothenberg KA, Siedlak SL, Bonda DJ, Lerner A, Tabaton M, Perry G, Smith MA. Dissociated amyloid-beta antibody levels as a serum biomarker for the progression of Alzheimer's disease: a population-based study. Experimental Gerontology. 45: 47-52. PMID 19819324 DOI: 10.1016/j.exger.2009.10.003  1
2009 Perry G, Moreira PI, Siedlak SL, Nunomura A, Zhu X, Smith MA. Natural oxidant balance in Parkinson disease. Archives of Neurology. 66: 1445. PMID 20008647 DOI: 10.1001/archneurol.2009.261  1
2009 Bonda DJ, Evans TA, Santocanale C, Llosá JC, Viña J, Bajic V, Castellani RJ, Siedlak SL, Perry G, Smith MA, Lee HG. Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease. Aging. 1: 382-8. PMID 19946466  1
2009 Lee HG, Chen Q, Wolfram JA, Richardson SL, Liner A, Siedlak SL, Zhu X, Ziats NP, Fujioka H, Felsher DW, Castellani RJ, Valencik ML, McDonald JA, Hoit BD, Lesnefsky EJ, et al. Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failure. Plos One. 4: e7172. PMID 19779629 DOI: 10.1371/journal.pone.0007172  1
2009 Bajić VP, Spremo-Potparević B, Zivković L, Bonda DJ, Siedlak SL, Casadesus G, Lee HG, Smith MA. The X-chromosome instability phenotype in Alzheimer's disease: a clinical sign of accelerating aging? Medical Hypotheses. 73: 917-20. PMID 19647374 DOI: 10.1016/j.mehy.2009.06.046  1
2009 Su B, Liu H, Wang X, Chen SG, Siedlak SL, Kondo E, Choi R, Takeda A, Castellani RJ, Perry G, Smith MA, Zhu X, Lee HG. Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease. Molecular Neurodegeneration. 4: 32. PMID 19627592 DOI: 10.1186/1750-1326-4-32  1
2009 Castellani RJ, Lee HG, Siedlak SL, Nunomura A, Hayashi T, Nakamura M, Zhu X, Perry G, Smith MA. Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta. Journal of Alzheimer's Disease : Jad. 18: 447-52. PMID 19584435 DOI: 10.3233/JAD-2009-1151  1
2009 Siedlak SL, Casadesus G, Webber KM, Pappolla MA, Atwood CS, Smith MA, Perry G. Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease. Free Radical Research. 43: 156-64. PMID 19160110 DOI: 10.1080/10715760802644694  1
2008 Myung NH, Zhu X, Kruman II, Castellani RJ, Petersen RB, Siedlak SL, Perry G, Smith MA, Lee HG. Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes. Age (Dordrecht, Netherlands). 30: 209-15. PMID 19424844 DOI: 10.1007/s11357-008-9050-7  1
2008 Wang X, Su B, Siedlak SL, Moreira PI, Fujioka H, Wang Y, Casadesus G, Zhu X. Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proceedings of the National Academy of Sciences of the United States of America. 105: 19318-23. PMID 19050078 DOI: 10.1073/pnas.0804871105  1
2008 Thakur A, Siedlak SL, James SL, Bonda DJ, Rao A, Webber KM, Camins A, Pallàs M, Casadesus G, Lee HG, Bowser R, Raina AK, Perry G, Smith MA, Zhu X. Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease. International Journal of Clinical and Experimental Pathology. 1: 134-46. PMID 18784806  1
2008 Collingwood JF, Chong RK, Kasama T, Cervera-Gontard L, Dunin-Borkowski RE, Perry G, Pósfai M, Siedlak SL, Simpson ET, Smith MA, Dobson J. Three-dimensional tomographic imaging and characterization of iron compounds within Alzheimer's plaque core material. Journal of Alzheimer's Disease : Jad. 14: 235-45. PMID 18560134  1
2008 Gustaw KA, Garrett MR, Lee HG, Castellani RJ, Zagorski MG, Prakasam A, Siedlak SL, Zhu X, Perry G, Petersen RB, Friedland RP, Smith MA. Antigen-antibody dissociation in Alzheimer disease: a novel approach to diagnosis. Journal of Neurochemistry. 106: 1350-6. PMID 18485104 DOI: 10.1111/j.1471-4159.2008.05477.x  1
2008 Perry G, Zhu X, Babar AK, Siedlak SL, Yang Q, Ito G, Iwatsubo T, Smith MA, Chen SG. Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies. Neuro-Degenerative Diseases. 5: 222-4. PMID 18322396 DOI: 10.1159/000113708  1
2008 Gonzalez-Cuyar LF, Perry G, Miyajima H, Atwood CS, Riveros-Angel M, Lyons PF, Siedlak SL, Smith MA, Castellani RJ. Redox active iron accumulation in aceruloplasminemia. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 28: 466-71. PMID 18282164 DOI: 10.1111/j.1440-1789.2008.00901.x  1
2008 Zhu X, Siedlak SL, Wang Y, Perry G, Castellani RJ, Cohen ML, Smith MA. Neuronal binucleation in Alzheimer disease hippocampus. Neuropathology and Applied Neurobiology. 34: 457-65. PMID 17995921 DOI: 10.1111/j.1365-2990.2007.00908.x  1
2008 Evans TA, Siedlak SL, Lu L, Fu X, Wang Z, McGinnis WR, Fakhoury E, Castellani RJ, Hazen SL, Walsh WJ, Lewis AT, Salomon RG, Smith MA, Perry G, Zhu X. The autistic phenotype exhibits a remarkably localized modification of brain protein by products of free radical-induced lipid oxidation American Journal of Biochemistry and Biotechnology. 4: 61-72.  1
2007 Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G. Increased autophagic degradation of mitochondria in Alzheimer disease. Autophagy. 3: 614-5. PMID 17786024  1
2007 Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G. Autophagocytosis of mitochondria is prominent in Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 66: 525-32. PMID 17549012 DOI: 10.1097/01.jnen.0000240476.73532.b0  1
2007 Thakur A, Wang X, Siedlak SL, Perry G, Smith MA, Zhu X. c-Jun phosphorylation in Alzheimer disease. Journal of Neuroscience Research. 85: 1668-73. PMID 17455299 DOI: 10.1002/jnr.21298  1
2007 Casadesus G, Moreira PI, Nunomura A, Siedlak SL, Bligh-Glover W, Balraj E, Petot G, Smith MA, Perry G. Indices of metabolic dysfunction and oxidative stress. Neurochemical Research. 32: 717-22. PMID 17342408 DOI: 10.1007/s11064-007-9296-y  1
2007 Zhu X, Smith MA, Honda K, Aliev G, Moreira PI, Nunomura A, Casadesus G, Harris PL, Siedlak SL, Perry G. Vascular oxidative stress in Alzheimer disease. Journal of the Neurological Sciences. 257: 240-6. PMID 17337008 DOI: 10.1016/j.jns.2007.01.039  1
2007 Casadesus G, Smith MA, Basu S, Hua J, Capobianco DE, Siedlak SL, Zhu X, Perry G. Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease. Molecular Neurodegeneration. 2: 2. PMID 17241462 DOI: 10.1186/1750-1326-2-2  1
2007 Bonda DJ, Webber KM, Siedlak SL, Perry G, Friedland RP, Smith MA. The pathology of Alzheimer disease elicits an in vivo immunological response American Journal of Immunology. 3: 10-14.  1
2006 Franco S, Blasco MA, Siedlak SL, Harris PL, Moreira PI, Perry G, Smith MA. Telomeres and telomerase in Alzheimer's disease: epiphenomena or a new focus for therapeutic strategy? Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 2: 164-8. PMID 19595878 DOI: 10.1016/j.jalz.2006.03.001  1
2006 Zhu X, Babar A, Siedlak SL, Yang Q, Ito G, Iwatsubo T, Smith MA, Perry G, Chen SG. LRRK2 in Parkinson's disease and dementia with Lewy bodies. Molecular Neurodegeneration. 1: 17. PMID 17137507 DOI: 10.1186/1750-1326-1-17  1
2006 Mei M, Su B, Harrison K, Chao M, Siedlak SL, Previll LA, Jackson L, Cai DX, Zhu X. Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease. Journal of Neurochemistry. 99: 1377-88. PMID 17064357 DOI: 10.1111/j.1471-4159.2006.04174.x  1
2006 Obrenovich ME, Smith MA, Siedlak SL, Chen SG, de la Torre JC, Perry G, Aliev G. Overexpression of GRK2 in Alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions. Neurotoxicity Research. 10: 43-56. PMID 17000469 DOI: 10.1007/BF03033333  1
2006 Zhu X, Siedlak SL, Smith MA, Perry G, Chen SG. LRRK2 protein is a component of Lewy bodies. Annals of Neurology. 60: 617-8; author reply . PMID 16847950 DOI: 10.1002/ana.20928  1
2006 Moreira PI, Zhu X, Liu Q, Honda K, Siedlak SL, Harris PL, Smith MA, Perry G. Compensatory responses induced by oxidative stress in Alzheimer disease. Biological Research. 39: 7-13. PMID 16629160  1
2005 Castellani RJ, Siedlak SL, Fortino AE, Perry G, Ghetti B, Smith MA. Chitin-like polysaccharides in Alzheimer's disease brains. Current Alzheimer Research. 2: 419-23. PMID 16248847 DOI: 10.2174/156720505774330555  1
2005 Petersen RB, Siedlak SL, Lee HG, Kim YS, Nunomura A, Tagliavini F, Ghetti B, Cras P, Moreira PI, Castellani RJ, Guentchev M, Budka H, Ironside JW, Gambetti P, Smith MA, et al. Redox metals and oxidative abnormalities in human prion diseases. Acta Neuropathologica. 110: 232-8. PMID 16096758 DOI: 10.1007/s00401-005-1034-4  1
2005 Honda K, Smith MA, Zhu X, Baus D, Merrick WC, Tartakoff AM, Hattier T, Harris PL, Siedlak SL, Fujioka H, Liu Q, Moreira PI, Miller FP, Nunomura A, Shimohama S, et al. Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron. The Journal of Biological Chemistry. 280: 20978-86. PMID 15767256 DOI: 10.1074/jbc.M500526200  1
2005 Liu Q, Smith MA, Avilá J, DeBernardis J, Kansal M, Takeda A, Zhu X, Nunomura A, Honda K, Moreira PI, Oliveira CR, Santos MS, Shimohama S, Aliev G, de la Torre J, ... ... Siedlak SL, et al. Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations. Free Radical Biology & Medicine. 38: 746-54. PMID 15721985 DOI: 10.1016/j.freeradbiomed.2004.11.005  1
2005 Liu Q, Lee HG, Honda K, Siedlak SL, Harris PL, Cash AD, Zhu X, Avila J, Nunomura A, Takeda A, Smith MA, Perry G. Tau modifiers as therapeutic targets for Alzheimer's disease. Biochimica Et Biophysica Acta. 1739: 211-5. PMID 15615639 DOI: 10.1016/j.bbadis.2004.06.021  1
2005 Moreira PI, Siedlak SL, Aliev G, Zhu X, Cash AD, Smith MA, Perry G. Oxidative stress mechanisms and potential therapeutics in Alzheimer disease. Journal of Neural Transmission (Vienna, Austria : 1996). 112: 921-32. PMID 15583960 DOI: 10.1007/s00702-004-0242-8  1
2005 Honda K, Moreira PI, Liu Q, Siedlak SL, Zhu X, Smith MA, Perry G. Redox active iron at the center of oxidative stress in Alzheimer disease Letters in Drug Design and Discovery. 2: 479-482. DOI: 10.2174/1570180054771545  1
2004 Liu Q, Xie F, Siedlak SL, Nunomura A, Honda K, Moreira PI, Zhua X, Smith MA, Perry G. Neurofilament proteins in neurodegenerative diseases. Cellular and Molecular Life Sciences : Cmls. 61: 3057-75. PMID 15583867 DOI: 10.1007/s00018-004-4268-8  1
2004 Zhu X, Wang Y, Ogawa O, Lee HG, Raina AK, Siedlak SL, Harris PL, Fujioka H, Shimohama S, Tabaton M, Atwood CS, Petersen RB, Perry G, Smith MA. Neuroprotective properties of Bcl-w in Alzheimer disease. Journal of Neurochemistry. 89: 1233-40. PMID 15147516 DOI: 10.1111/j.1471-4159.2004.02416.x  1
2004 Vitali A, Piccini A, Borghi R, Fornaro P, Siedlak SL, Smith MA, Gambetti P, Ghetti B, Tabaton M. Soluble amyloid beta-protein is increased in frontotemporal dementia with tau gene mutations. Journal of Alzheimer's Disease : Jad. 6: 45-51. PMID 15004327  1
2003 Perry G, Nunomura A, Raina AK, Aliev G, Siedlak SL, Harris PL, Casadesus G, Petersen RB, Bligh-Glover W, Balraj E, Petot GJ, Smith MA. A metabolic basis for Alzheimer disease. Neurochemical Research. 28: 1549-52. PMID 14570400 DOI: 10.1023/A:1025678510480  1
2003 Aliev G, Seyidova D, Lamb BT, Obrenovich ME, Siedlak SL, Vinters HV, Friedland RP, LaManna JC, Smith MA, Perry G. Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice. Neurological Research. 25: 665-74. PMID 14503022 DOI: 10.1179/016164103101201977  1
2003 Zhu X, Sun Z, Lee HG, Siedlak SL, Perry G, Smith MA. Distribution, levels, and activation of MEK1 in Alzheimer's disease. Journal of Neurochemistry. 86: 136-42. PMID 12807433 DOI: 10.1046/j.1471-4159.2003.01820.x  1
2003 Cash AD, Aliev G, Siedlak SL, Nunomura A, Fujioka H, Zhu X, Raina AK, Vinters HV, Tabaton M, Johnson AB, Paula-Barbosa M, Avíla J, Jones PK, Castellani RJ, Smith MA, et al. Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation. The American Journal of Pathology. 162: 1623-7. PMID 12707046  1
2003 Dong J, Atwood CS, Anderson VE, Siedlak SL, Smith MA, Perry G, Carey PR. Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence. Biochemistry. 42: 2768-73. PMID 12627941 DOI: 10.1021/bi0272151  1
2003 Perry G, Taddeo MA, Petersen RB, Castellani RJ, Harris PL, Siedlak SL, Cash AD, Liu Q, Nunomura A, Atwood CS, Smith MA. Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 16: 77-81. PMID 12572666 DOI: 10.1023/A:1020731021276  1
2002 Aliev G, Seyidova D, Neal ML, Shi J, Lamb BT, Siedlak SL, Vinters HV, Head E, Perry G, Lamanna JC, Friedland RP, Cotman CW. Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice. Annals of the New York Academy of Sciences. 977: 45-64. PMID 12480733  1
2002 Hartzler AW, Zhu X, Siedlak SL, Castellani RJ, Avilá J, Perry G, Smith MA. The p38 pathway is activated in Pick disease and progressive supranuclear palsy: a mechanistic link between mitogenic pathways, oxidative stress, and tau. Neurobiology of Aging. 23: 855-9. PMID 12392790 DOI: 10.1016/S0197-4580(02)00029-5  1
2002 Shi J, Perry G, Berridge MS, Aliev G, Siedlak SL, Smith MA, LaManna JC, Friedland RP. Labeling of cerebral amyloid beta deposits in vivo using intranasal basic fibroblast growth factor and serum amyloid P component in mice. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 43: 1044-51. PMID 12163630  1
2002 Zhang J, Montine TJ, Smith MA, Siedlak SL, Gu G, Robertson D, Perry G. The mitochondrial common deletion in Parkinson's disease and related movement disorders. Parkinsonism & Related Disorders. 8: 165-70. PMID 12039426 DOI: 10.1016/S1353-8020(01)00041-4  1
2002 Guentchev M, Siedlak SL, Jarius C, Tagliavini F, Castellani RJ, Perry G, Smith MA, Budka H. Oxidative damage to nucleic acids in human prion disease. Neurobiology of Disease. 9: 275-81. PMID 11950273 DOI: 10.1006/nbdi.2002.0477  1
2002 Castellani RJ, Perry G, Siedlak SL, Nunomura A, Shimohama S, Zhang J, Montine T, Sayre LM, Smith MA. Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans. Neuroscience Letters. 319: 25-8. PMID 11814645 DOI: 10.1016/S0304-3940(01)02514-9  1
2002 Wataya T, Nunomura A, Smith MA, Siedlak SL, Harris PL, Shimohama S, Szweda LI, Kaminski MA, Avila J, Price DL, Cleveland DW, Sayre LM, Perry G. High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal. The Journal of Biological Chemistry. 277: 4644-8. PMID 11733539 DOI: 10.1074/jbc.M110913200  1
2001 Raina AK, Hochman A, Zhu X, Rottkamp CA, Nunomura A, Siedlak SL, Boux H, Castellani RJ, Perry G, Smith MA. Abortive apoptosis in Alzheimer's disease. Acta Neuropathologica. 101: 305-10. PMID 11355301  1
2001 Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, Atwood CS, Johnson AB, Kress Y, Vinters HV, Tabaton M, Shimohama S, Cash AD, Siedlak SL, Harris PL, Jones PK, et al. Mitochondrial abnormalities in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 3017-23. PMID 11312286  1
2001 Alicigüzel Y, Ozdem SN, Ozdem SS, Karayalçin U, Siedlak SL, Perry G, Smith MA. Erythrocyte, plasma, and serum antioxidant activities in untreated toxic multinodular goiter patients. Free Radical Biology & Medicine. 30: 665-70. PMID 11295364 DOI: 10.1016/S0891-5849(00)00509-8  1
2000 Kim HT, Russell RL, Raina AK, Harris PL, Siedlak SL, Zhu X, Petersen RB, Shimohama S, Smith MA, Perry G. Protein disulfide isomerase in Alzheimer disease. Antioxidants & Redox Signaling. 2: 485-9. PMID 11229362 DOI: 10.1089/15230860050192260  1
2000 Castellani RJ, Siedlak SL, Perry G, Smith MA. Sequestration of iron by Lewy bodies in Parkinson's disease. Acta Neuropathologica. 100: 111-4. PMID 10963356  1
2000 Takeda A, Smith MA, Avilá J, Nunomura A, Siedlak SL, Zhu X, Perry G, Sayre LM. In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification. Journal of Neurochemistry. 75: 1234-41. PMID 10936206 DOI: 10.1046/j.1471-4159.2000.0751234.x  1
2000 Gerst JL, Raina AK, Pirim I, McShea A, Harris PL, Siedlak SL, Takeda A, Petersen RB, Smith MA. Altered cell-matrix associated ADAM proteins in Alzheimer disease. Journal of Neuroscience Research. 59: 680-4. PMID 10686596 DOI: 10.1002/(SICI)1097-4547(20000301)59:5<680::AID-JNR11>3.0.CO;2-6  1
1999 Russell RL, Siedlak SL, Raina AK, Bautista JM, Smith MA, Perry G. Increased neuronal glucose-6-phosphate dehydrogenase and sulfhydryl levels indicate reductive compensation to oxidative stress in Alzheimer disease. Archives of Biochemistry and Biophysics. 370: 236-9. PMID 10510282 DOI: 10.1006/abbi.1999.1404  1
1999 Perry G, Roder H, Nunomura A, Takeda A, Friedlich AL, Zhu X, Raina AK, Holbrook N, Siedlak SL, Harris PL, Smith MA. Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation. Neuroreport. 10: 2411-5. PMID 10439473  1
1999 Gerst JL, Siedlak SL, Nunomura A, Castellani R, Perry G, Smith MA. Role of oxidative stress in frontotemporal dementia. Dementia and Geriatric Cognitive Disorders. 10: 85-7. PMID 10436348 DOI: 10.1159/000051220  1
1998 Velasco ME, Smith MA, Siedlak SL, Nunomura A, Perry G. Striation is the characteristic neuritic abnormality in Alzheimer disease. Brain Research. 813: 329-33. PMID 9838181 DOI: 10.1016/S0006-8993(98)01034-8  1
1998 Perry G, Smith MA, McCann CE, Siedlak SL, Jones PK, Friedland RP. Cerebrovascular muscle atrophy is a feature of Alzheimer's disease. Brain Research. 791: 63-6. PMID 9593825 DOI: 10.1016/S0006-8993(98)00006-7  1
1998 Smith MA, Hirai K, Hsiao K, Pappolla MA, Harris PL, Siedlak SL, Tabaton M, Perry G. Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress. Journal of Neurochemistry. 70: 2212-5. PMID 9572310  1
1998 Smith MA, Wehr K, Harris PL, Siedlak SL, Connor JR, Perry G. Abnormal localization of iron regulatory protein in Alzheimer's disease. Brain Research. 788: 232-6. PMID 9555030 DOI: 10.1016/S0006-8993(98)00002-X  1
1996 Ali SM, Siedlak SL, Gonzalez-DeWhitt PA, Altman RA, Glendening JM, Lowery DE, Savage MJ, Polites HG, Perry G, Greenberg BD. Artifactual strain-specific signs of incipient brain amyloidosis in APP transgenic mice. Neurobiology of Aging. 17: 223-34. PMID 8744403 DOI: 10.1016/0197-4580(95)02065-9  1
1996 Greenberg BD, Savage MJ, Howland DS, Ali SM, Siedlak SL, Perry G, Siman R, Scott RW. APP transgenesis: approaches toward the development of animal models for Alzheimer disease neuropathology. Neurobiology of Aging. 17: 153-71. PMID 8744397 DOI: 10.1016/0197-4580(96)00001-2  1
1996 Smith MA, Siedlak SL, Richey PL, Nagaraj RH, Elhammer A, Perry G. Quantitative solubilization and analysis of insoluble paired helical filaments from Alzheimer disease. Brain Research. 717: 99-108. PMID 8738259 DOI: 10.1016/0006-8993(95)01473-X  1
1995 Richey PL, Siedlak SL, Smith MA, Perry G. Apolipoprotein E interaction with the neurofibrillary tangles and senile plaques in Alzheimer disease: implications for disease pathogenesis. Biochemical and Biophysical Research Communications. 208: 657-63. PMID 7695621 DOI: 10.1006/bbrc.1995.1389  1
1995 Cras P, Smith MA, Richey PL, Siedlak SL, Mulvihill P, Perry G. Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease. Acta Neuropathologica. 89: 291-5. PMID 7610759 DOI: 10.1007/BF00309621  1
1995 Smith MA, Siedlak SL, Richey PL, Mulvihill P, Ghiso J, Frangione B, Tagliavini F, Giaccone G, Bugiani O, Praprotnik D. Tau protein directly interacts with the amyloid beta-protein precursor: implications for Alzheimer's disease. Nature Medicine. 1: 365-9. PMID 7585068  1
1993 Kawai M, Kalaria RN, Cras P, Siedlak SL, Velasco ME, Shelton ER, Chan HW, Greenberg BD, Perry G. Degeneration of vascular muscle cells in cerebral amyloid angiopathy of Alzheimer disease. Brain Research. 623: 142-6. PMID 8221082 DOI: 10.1016/0006-8993(93)90021-E  1
1993 Perry G, Richey PL, Siedlak SL, Smith MA, Mulvihill P, DeWitt DA, Barnett J, Greenberg BD, Kalaria RN. Immunocytochemical evidence that the beta-protein precursor is an integral component of neurofibrillary tangles of Alzheimer's disease. The American Journal of Pathology. 143: 1586-93. PMID 7504885  1
1992 Perry G, Cras P, Siedlak SL, Tabaton M, Kawai M. Beta protein immunoreactivity is found in the majority of neurofibrillary tangles of Alzheimer's disease. The American Journal of Pathology. 140: 283-90. PMID 1739122  1
1992 Perry G, Richey P, Siedlak SL, Galloway P, Kawai M, Cras P. Basic fibroblast growth factor binds to filamentous inclusions of neurodegenerative diseases. Brain Research. 579: 350-2. PMID 1628222 DOI: 10.1016/0006-8993(92)90074-J  1
1991 Perry G, Siedlak SL, Richey P, Kawai M, Cras P, Kalaria RN, Galloway PG, Scardina JM, Cordell B, Greenberg BD. Association of heparan sulfate proteoglycan with the neurofibrillary tangles of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 11: 3679-83. PMID 1941102  1
1991 Siedlak SL, Cras P, Kawai M, Richey P, Perry G. Basic fibroblast growth factor binding is a marker for extracellular neurofibrillary tangles in Alzheimer disease. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 39: 899-904. PMID 1865106  1
1991 Vande Weghe J, Cras P, Kawai M, Siedlak SL, Tabaton M, Greenberg B, Perry G. Dystrophic neurites infiltrate extracellular neurofibrillary tangles in Alzheimer disease. Brain Research. 560: 303-5. PMID 1760735 DOI: 10.1016/0006-8993(91)91247-X  1
1990 Golde TE, Palmert MR, Estus S, Usiak M, Siedlak SL, Perry G, Younkin LH, Younkin SG. The β amyloid protein precursor: Analysis of mRNAs in ad and control brains and of soluble derivatives in human cerebrospinal fluid Molecular Biology and Genetics of Alzheimer's Disease: Proceedings of the International Symposium On Dementia: Molecular Biology and Genetics of Alzheimer's Disease. Ics884. 137-147.  1
1989 Palmert MR, Siedlak SL, Podlisny MB, Greenberg B, Shelton ER, Chan HW, Usiak M, Selkoe DJ, Perry G, Younkin SG. Soluble derivatives of the beta amyloid protein precursor of Alzheimer's disease are labeled by antisera to the beta amyloid protein. Biochemical and Biophysical Research Communications. 165: 182-8. PMID 2480122 DOI: 10.1016/0006-291X(89)91052-8  1
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