Tracy L. Young-Pearse, Ph.D. - Publications

Affiliations: 
Neurology Harvard University/Brigham and Women's 
Area:
Development, schizophrenia, Alzheimer's disease

61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Bartosch AMW, Youth EHH, Hansen S, Wu Y, Buchanan HM, Kaufman ME, Xiao H, Koo SY, Ashok A, Sivakumar S, Soni RK, Dumitrescu LC, Lam TG, Ropri AS, Lee AJ, ... ... Young-Pearse TL, et al. ZCCHC17 modulates neuronal RNA splicing and supports cognitive resilience in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 38050142 DOI: 10.1523/JNEUROSCI.2324-22.2023  0.373
2023 Terzioglu G, Young-Pearse TL. Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer's disease. Molecular Neurodegeneration. 18: 89. PMID 38017562 DOI: 10.1186/s13024-023-00674-9  0.331
2023 Chou V, Pearse RV, Aylward AJ, Ashour N, Taga M, Terzioglu G, Fujita M, Fancher SB, Sigalov A, Benoit CR, Lee H, Lam M, Seyfried NT, Bennett DA, De Jager PL, ... ... Young-Pearse TL, et al. INPP5D regulates inflammasome activation in human microglia. Nature Communications. 14: 7552. PMID 38016942 DOI: 10.1038/s41467-023-42819-w  0.335
2023 Lee H, Aylward AJ, Pearse RV, Lish AM, Hsieh YC, Augur ZM, Benoit CR, Chou V, Knupp A, Pan C, Goberdhan S, Duong DM, Seyfried NT, Bennett DA, Taga MF, ... ... Young-Pearse TL, et al. Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer's disease risk gene SORL1. Cell Reports. 112994. PMID 37611586 DOI: 10.1016/j.celrep.2023.112994  0.428
2023 Lomoio S, Pandey RS, Rouleau N, Menicacci B, Kim W, Cantley WL, Haydon PG, Bennett DA, Young-Pearse TL, Carter GW, Kaplan DL, Tesco G. 3D bioengineered neural tissue generated from patient-derived iPSCs mimics time-dependent phenotypes and transcriptional features of Alzheimer's disease. Molecular Psychiatry. PMID 37365240 DOI: 10.1038/s41380-023-02147-3  0.38
2023 Merchant JP, Zhu K, Henrion MYR, Zaidi SSA, Lau B, Moein S, Alamprese ML, Pearse RV, Bennett DA, Ertekin-Taner N, Young-Pearse TL, Chang R. Predictive network analysis identifies JMJD6 and other potential key drivers in Alzheimer's disease. Communications Biology. 6: 503. PMID 37188718 DOI: 10.1038/s42003-023-04791-5  0.376
2023 Young-Pearse TL, Lee H, Hsieh YC, Chou V, Selkoe DJ. Moving beyond amyloid and tau to capture the biological heterogeneity of Alzheimer's disease. Trends in Neurosciences. PMID 37019812 DOI: 10.1016/j.tins.2023.03.005  0.5
2023 Bartosch AMW, Youth EHH, Hansen S, Kaufman ME, Xiao H, Koo SY, Ashok A, Sivakumar S, Soni RK, Dumitrescu LC, Lam TG, Ropri AS, Lee AJ, Klein HU, Vardarajan BN, ... ... Young-Pearse TL, et al. ZCCHC17 modulates neuronal RNA splicing and supports cognitive resilience in Alzheimer's disease. Biorxiv : the Preprint Server For Biology. PMID 36993746 DOI: 10.1101/2023.03.21.533654  0.397
2023 Wang Z, Jin M, Hong W, Liu W, Reczek D, Lagomarsino VN, Hu Y, Weeden T, Frosch MP, Young-Pearse TL, Pradier L, Selkoe D, Walsh DM. Learnings about Aβ from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer's disease immunotherapeutics. Acta Neuropathologica Communications. 11: 39. PMID 36899414 DOI: 10.1186/s40478-023-01511-2  0.648
2023 Lee H, Aylward AJ, Pearse RV, Hsieh YC, Augur ZM, Benoit CR, Chou V, Knupp A, Pan C, Goberdhan S, Duong DM, Seyfried NT, Bennett DA, Klein HU, De Jager PL, ... ... Young-Pearse TL, et al. Cell-type-specific regulation of APOE levels in human neurons by the Alzheimer's disease risk gene SORL1. Biorxiv : the Preprint Server For Biology. PMID 36865313 DOI: 10.1101/2023.02.25.530017  0.434
2023 Hong W, Liu W, Desousa AO, Young-Pearse T, Walsh DM. Methods for the isolation and analysis of Aβ from postmortem brain. Frontiers in Neuroscience. 17: 1108715. PMID 36777642 DOI: 10.3389/fnins.2023.1108715  0.637
2022 Hsieh YC, Negri J, He A, Pearse RV, Liu L, Duong DM, Chibnik LB, Bennett DA, Seyfried NT, Young-Pearse TL. Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity. Molecular Neurodegeneration. 17: 61. PMID 36131294 DOI: 10.1186/s13024-022-00558-4  0.444
2022 Fernandez MA, Bah F, Ma L, Lee Y, Schmidt M, Welch E, Morrow EM, Young-Pearse TL. Loss of endosomal exchanger NHE6 leads to pathological changes in tau in human neurons. Stem Cell Reports. 17: 2111-2126. PMID 36055242 DOI: 10.1016/j.stemcr.2022.08.001  0.606
2022 Vermeulen MC, Pearse R, Young-Pearse T, Mostafavi S. Mosaic loss of Chromosome Y in aged human microglia. Genome Research. PMID 36041859 DOI: 10.1101/gr.276409.121  0.335
2022 van der Linden RJ, Gerritsen JS, Liao M, Widomska J, Pearse RV, White FM, Franke B, Young-Pearse TL, Poelmans G. RNA-binding protein ELAVL4/HuD ameliorates Alzheimer's disease-related molecular changes in human iPSC-derived neurons. Progress in Neurobiology. 217: 102316. PMID 35843356 DOI: 10.1016/j.pneurobio.2022.102316  0.462
2022 Palotai M, Schregel K, Nazari N, Merchant JP, Taylor WM, Guttmann CRG, Sinkus R, Young-Pearse TL, Patz S. Magnetic resonance elastography to study the effect of amyloid plaque accumulation in a mouse model. Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging. PMID 35384128 DOI: 10.1111/jon.12996  0.335
2022 Liu L, Lauro BM, He A, Lee H, Bhattarai S, Wolfe MS, Bennett DA, Karch CM, Young-Pearse T, Selkoe DJ. Identification of the Aβ37/42 peptide ratio in CSF as an improved Aβ biomarker for Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 35278341 DOI: 10.1002/alz.12646  0.546
2022 Wu CI, Vinton EA, Pearse RV, Heo K, Aylward AJ, Hsieh YC, Bi Y, Adeleye S, Fancher S, Duong DM, Seyfried NT, Schwarz TL, Young-Pearse TL. APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer's pathology in trisomy 21 neurons. Molecular Psychiatry. PMID 35194165 DOI: 10.1038/s41380-022-01454-5  0.365
2022 You Y, Muraoka S, Jedrychowski MP, Hu J, McQuade AK, Young-Pearse T, Aslebagh R, Shaffer SA, Gygi SP, Blurton-Jones M, Poon WW, Ikezu T. Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain. Journal of Extracellular Vesicles. 11: e12183. PMID 35029059 DOI: 10.1002/jev2.12183  0.416
2021 Lee Y, Miller MR, Fernandez MA, Berg EL, Prada AM, Ouyang Q, Schmidt M, Silverman JL, Young-Pearse TL, Morrow EM. Early lysosome defects precede neurodegeneration with amyloid-β and tau aggregation in NHE6-null rat brain. Brain : a Journal of Neurology. PMID 34928329 DOI: 10.1093/brain/awab467  0.633
2021 Lagomarsino VN, Pearse RV, Liu L, Hsieh YC, Fernandez MA, Vinton EA, Paull D, Felsky D, Tasaki S, Gaiteri C, Vardarajan B, Lee H, Muratore CR, Benoit CR, Chou V, ... ... Young-Pearse TL, et al. Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors. Neuron. PMID 34473944 DOI: 10.1016/j.neuron.2021.08.003  0.577
2020 Sanderson JB, De S, Jiang H, Rovere M, Jin M, Zaccagnini L, Hays Watson A, De Boni L, Lagomarsino VN, Young-Pearse TL, Liu X, Pochapsky TC, Hyman BT, Dickson DW, Klenerman D, et al. Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies. Brain Communications. 2: fcaa010. PMID 32280944 DOI: 10.1093/braincomms/fcaa010  0.461
2020 Rice HC, Marcassa G, Chrysidou I, Horré K, Young-Pearse TL, Müller UC, Saito T, Saido TC, Vassar R, de Wit J, De Strooper B. Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model. Molecular Neurodegeneration. 15: 3. PMID 31915042 DOI: 10.1186/S13024-019-0356-Y  0.762
2019 Corbett GT, Wang Z, Hong W, Colom-Cadena M, Rose J, Liao M, Asfaw A, Hall TC, Ding L, DeSousa A, Frosch MP, Collinge J, Harris DA, Perkinton MS, Spires-Jones TL, ... Young-Pearse TL, et al. PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins. Acta Neuropathologica. PMID 31853635 DOI: 10.1007/S00401-019-02114-9  0.674
2019 Babiloni C, Blinowska K, Bonanni L, Cichocki A, De Haan W, Del Percio C, Dubois B, Escudero J, Fernández A, Frisoni G, Guntekin B, Hajos M, Hampel H, Ifeachor E, Kilborn K, ... ... Young-Pearse T, et al. What electrophysiology tells us about Alzheimer's disease: a window into the synchronization and connectivity of brain neurons. Neurobiology of Aging. 85: 58-73. PMID 31739167 DOI: 10.1016/J.Neurobiolaging.2019.09.008  0.442
2019 Imberdis T, Negri J, Ramalingam N, Terry-Kantor E, Ho GPH, Fanning S, Stirtz G, Kim TE, Levy OA, Young-Pearse TL, Selkoe D, Dettmer U. Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase. Proceedings of the National Academy of Sciences of the United States of America. PMID 31548371 DOI: 10.1073/Pnas.1903216116  0.711
2019 Pescosolido MF, Kavanaugh BC, Pochet N, Schmidt M, Jerskey BA, Rogg JM, De Jager PL, Young-Pearse TL, Liu JS, Morrow EM. Complex Neurological Phenotype in Female Carriers of Mutations. Molecular Neuropsychiatry. 5: 98-108. PMID 31192222 DOI: 10.1159/000496341  0.486
2019 Klein HU, McCabe C, Gjoneska E, Sullivan SE, Kaskow BJ, Tang A, Smith RV, Xu J, Pfenning AR, Bernstein BE, Meissner A, Schneider JA, Mostafavi S, Tsai LH, Young-Pearse TL, et al. Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains. Nature Neuroscience. 22: 37-46. PMID 30559478 DOI: 10.1038/S41593-018-0291-1  0.455
2018 Srikanth P, Lagomarsino VN, Pearse RV, Liao M, Ghosh S, Nehme R, Seyfried N, Eggan K, Young-Pearse TL. Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression. Translational Psychiatry. 8: 245. PMID 30410030 DOI: 10.1038/S41398-018-0281-9  0.371
2018 Sullivan SE, Liao M, Smith RV, White C, Lagomarsino VN, Xu J, Taga M, Bennett DA, De Jager PL, Young-Pearse TL. Candidate-based screening via gene modulation in human neurons and astrocytes implicates FERMT2 in Aβ and TAU proteostasis. Human Molecular Genetics. PMID 30371777 DOI: 10.1093/Hmg/Ddy376  0.527
2018 Raj T, Li YI, Wong G, Humphrey J, Wang M, Ramdhani S, Wang YC, Ng B, Gupta I, Haroutunian V, Schadt EE, Young-Pearse T, Mostafavi S, Zhang B, Sklar P, et al. Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility. Nature Genetics. PMID 30297968 DOI: 10.1038/S41588-018-0238-1  0.367
2018 Jin M, O'Nuallain B, Hong W, Boyd J, Lagomarsino VN, O'Malley TT, Liu W, Vanderburg CR, Frosch MP, Young-Pearse T, Selkoe DJ, Walsh DM. An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer's disease. Nature Communications. 9: 2676. PMID 29992960 DOI: 10.1038/S41467-018-05068-W  0.716
2018 Yu L, Petyuk VA, Gaiteri C, Mostafavi S, Young-Pearse T, Shah RC, Buchman AS, Schneider JA, Piehowski PD, Sontag RL, Fillmore TL, Shi T, Smith RD, De Jager PL, Bennett DA. Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia. Annals of Neurology. PMID 29908079 DOI: 10.1002/Ana.25266  0.331
2018 Mostafavi S, Gaiteri C, Sullivan SE, White CC, Tasaki S, Xu J, Taga M, Klein HU, Patrick E, Komashko V, McCabe C, Smith R, Bradshaw EM, Root DE, Regev A, ... ... Young-Pearse TL, et al. A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer's disease. Nature Neuroscience. 21: 811-819. PMID 29802388 DOI: 10.1038/S41593-018-0154-9  0.405
2018 Srikanth P, Lagomarsino VN, Muratore CR, Ryu SC, He A, Taylor WM, Zhou C, Arellano M, Young-Pearse TL. Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids. Translational Psychiatry. 8: 77. PMID 29643329 DOI: 10.1038/S41398-018-0122-X  0.39
2018 Guix FX, Corbett GT, Cha DJ, Mustapic M, Liu W, Mengel D, Chen Z, Aikawa E, Young-Pearse T, Kapogiannis D, Selkoe DJ, Walsh DM. Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles. International Journal of Molecular Sciences. 19. PMID 29495441 DOI: 10.3390/Ijms19030663  0.705
2017 Muratore CR, Zhou C, Liao M, Fernandez MA, Taylor WM, Lagomarsino VN, Pearse RV, Rice HC, Negri JM, He A, Srikanth P, Callahan DG, Shin T, Zhou M, Bennett DA, ... ... Young-Pearse TL, et al. Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability. Stem Cell Reports. PMID 29153990 DOI: 10.1016/J.Stemcr.2017.10.015  0.79
2017 Wang Z, Jackson RJ, Hong W, Taylor WM, Corbett GT, Moreno A, Liu W, Li S, Frosch MP, Slutsky I, Young-Pearse T, Spires-Jones TL, Walsh DM. Human brain-derived Aβ oligomers bind to synapses and disrupt synaptic activity in a manner that requires APP. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29101243 DOI: 10.1523/Jneurosci.2009-17.2017  0.653
2017 Sato Y, Uchida Y, Hu J, Young-Pearse TL, Niikura T, Mukouyama YS. Soluble APP functions as a vascular niche signal that controls adult neural stem cell number. Development (Cambridge, England). PMID 28694255 DOI: 10.1242/Jcs.209023  0.331
2017 Callahan DG, Taylor WM, Tilearcio M, Cavanaugh T, Selkoe DJ, Young-Pearse TL. Embryonic mosaic deletion of APP results in displaced Reelin-expressing cells in the cerebral cortex. Developmental Biology. PMID 28284905 DOI: 10.1016/J.Ydbio.2017.03.007  0.62
2016 Liao MC, Muratore CR, Gierahn TM, Sullivan SE, Srikanth P, De Jager PL, Love JC, Young-Pearse TL. Single-Cell Detection of Secreted Aβ and sAPPα from Human IPSC-Derived Neurons and Astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 1730-46. PMID 26843653 DOI: 10.1523/Jneurosci.2735-15.2016  0.476
2015 Young-Pearse TL, Morrow EM. Modeling developmental neuropsychiatric disorders with iPSC technology: challenges and opportunities. Current Opinion in Neurobiology. 36: 66-73. PMID 26517284 DOI: 10.1016/J.Conb.2015.10.006  0.56
2015 Sullivan SE, Young-Pearse T. Induced pluripotent stem cells as a discovery tool for Alzheimer׳s disease. Brain Research. PMID 26459988 DOI: 10.1016/J.Brainres.2015.10.005  0.492
2015 Srikanth P, Han K, Callahan DG, Makovkina E, Muratore CR, Lalli MA, Zhou H, Boyd JD, Kosik KS, Selkoe DJ, Young-Pearse TL. Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate. Cell Reports. PMID 26299970 DOI: 10.1016/J.Celrep.2015.07.061  0.598
2015 Kanmert D, Cantlon A, Muratore CR, Jin M, O'Malley TT, Lee G, Young-Pearse TL, Selkoe DJ, Walsh DM. C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 10851-65. PMID 26224867 DOI: 10.1523/Jneurosci.0387-15.2015  0.712
2014 Muratore CR, Srikanth P, Callahan DG, Young-Pearse TL. Comparison and optimization of hiPSC forebrain cortical differentiation protocols. Plos One. 9: e105807. PMID 25165848 DOI: 10.1371/Journal.Pone.0105807  0.435
2014 Preitner N, Quan J, Nowakowski DW, Hancock ML, Shi J, Tcherkezian J, Young-Pearse TL, Flanagan JG. APC is an RNA-binding protein, and its interactome provides a link to neural development and microtubule assembly. Cell. 158: 368-82. PMID 25036633 DOI: 10.1016/J.Cell.2014.05.042  0.325
2014 Srikanth P, Young-Pearse TL. Stem cells on the brain: modeling neurodevelopmental and neurodegenerative diseases using human induced pluripotent stem cells. Journal of Neurogenetics. 28: 5-29. PMID 24628482 DOI: 10.3109/01677063.2014.881358  0.355
2014 Muratore CR, Rice HC, Srikanth P, Callahan DG, Shin T, Benjamin LN, Walsh DM, Selkoe DJ, Young-Pearse TL. The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons. Human Molecular Genetics. 23: 3523-36. PMID 24524897 DOI: 10.1093/Hmg/Ddu064  0.807
2013 Rice HC, Young-Pearse TL, Selkoe DJ. Systematic evaluation of candidate ligands regulating ectodomain shedding of amyloid precursor protein. Biochemistry. 52: 3264-77. PMID 23597280 DOI: 10.1021/Bi400165F  0.76
2013 Muratore C, Rice H, Srikanth P, Selkoe D, Young-Pearse T. O1-01-05: Human iPSC-derived neurons reveal novel effects of the APP London mutation and show cell fate-specific Alzheimer's disease relevant phenotypes Alzheimer's & Dementia. 9: P126-P127. DOI: 10.1016/J.Jalz.2013.04.053  0.762
2012 Rice HC, Townsend M, Bai J, Suth S, Cavanaugh W, Selkoe DJ, Young-Pearse TL. Pancortins interact with amyloid precursor protein and modulate cortical cell migration. Development (Cambridge, England). 139: 3986-96. PMID 22992957 DOI: 10.1242/Dev.082909  0.763
2011 Rice H, Young-Pearse T, Selkoe D. P2-310: Candidate-based search for Amyloid Precursor Protein ligands that modulate α-secretase cleavage Alzheimer's & Dementia. 7: S409-S410. DOI: 10.1016/J.Jalz.2011.05.1188  0.72
2010 Rice H, Suth S, Cavanaugh W, Bai J, Young-Pearse TL. In utero electroporation followed by primary neuronal culture for studying gene function in subset of cortical neurons. Journal of Visualized Experiments : Jove. PMID 20972409 DOI: 10.3791/2103  0.717
2010 Young-Pearse TL, Suth S, Luth ES, Sawa A, Selkoe DJ. Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 10431-40. PMID 20685985 DOI: 10.1523/Jneurosci.1445-10.2010  0.62
2010 Shahani N, Young-Pearse T, Selkoe D, Sawa A. P2-247: Role of Disrupted-in-Schizophrenia-1 (DISC1) in amyloid precursor protein (APP) processing and Aβ generation Alzheimer's & Dementia. 6: S386-S387. DOI: 10.1016/J.Jalz.2010.05.1296  0.539
2008 Young-Pearse TL, Chen AC, Chang R, Marquez C, Selkoe DJ. Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1. Neural Development. 3: 15. PMID 18573216 DOI: 10.1186/1749-8104-3-15  0.688
2007 Young-Pearse TL, Bai J, Chang R, Zheng JB, LoTurco JJ, Selkoe DJ. A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 14459-69. PMID 18160654 DOI: 10.1523/Jneurosci.4701-07.2007  0.748
2006 Young-Pearse TL, Ivic L, Kriegstein AR, Cepko CL. Characterization of mice with targeted deletion of glycine receptor alpha 2. Molecular and Cellular Biology. 26: 5728-34. PMID 16847326 DOI: 10.1128/Mcb.00237-06  0.512
2006 Walsh DM, Jin M, Wang Z, Liu W, Lagomarsino V, Weeden T, Reczek D, Young-Pearse T, Pradier L, Selkoe DJ. P1-106: A HEAD-TO-HEAD COMPARISON OF LEAD CLINICAL ANTI-Aβ ANTIBODIES Alzheimer's & Dementia. 14: P312-P312. DOI: 10.1016/J.Jalz.2018.06.109  0.602
2006 Young-Pearse TL, Bai J, Zheng J, LoTurco J, Selkoe DJ. O4-05-08: In utero gene transfer reveals a function for APP in cortical cell migration Alzheimer's & Dementia. 2: S86-S87. DOI: 10.1016/J.Jalz.2006.05.334  0.65
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