Robert J. Lefkowitz

Affiliations: 
Duke University, Durham, NC 
Area:
G protein-coupled receptors
Website:
http://cardiology.medicine.duke.edu/faculty/details/0096962
Google:
"Robert Lefkowitz"
Bio:

The Nobel Prize in Chemistry 2012 was awarded jointly to Robert J. Lefkowitz and Brian K. Kobilka "for studies of G-protein-coupled receptors"

Mean distance: 13.4 (cluster 11)
 
SNBCP
Cross-listing: Chemistry Tree - Cell Biology Tree

Parents

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Ira Pastan post-doc 1968-1970 NIH
Jesse Roth post-doc 1968-1970 NIH
Edgar Haber post-doc 1970-1973 Harvard Medical School

Children

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Henrik G. Dohlman grad student Duke University / HHMI (Physics Tree)
Seungkirl Ahn grad student 2002 Duke
Alberuni M. Zamah grad student 2002 Duke
Kelly N. Nobles grad student 2010 Duke
Michel Bouvier post-doc Université de Montréal
Yehia Daaka post-doc Duke University School of Medicine (Chemistry Tree)
Marc Caron post-doc 1973-1976 Duke
Lee Limbird post-doc 1973-1978 Duke
Warren J. Strittmatter post-doc 1978-1978 Duke
Richard A. Cerione post-doc 1982-1985 Duke University / HHMI (Chemistry Tree)
David R. Sibley post-doc 1983-1987 Duke
Brian K. Kobilka post-doc 1984-1989 Duke
Richard T Premont post-doc 1992-1997 Duke University School of Medicine (Chemistry Tree)
Randy A. Hall post-doc 1996-1999 Duke
Makoto R. Hara post-doc 2006-2012 Duke
Martin J. Lohse research scientist Duke University / HHMI
Jennifer J. Linderman research scientist 1996-1997 Duke

Collaborators

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Abraham White collaborator 1975-1981 Duke (Chemistry Tree)
Bruno Giros collaborator 1992-1994 Duke University Medical Center
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Publications

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Wingler LM, McMahon C, Staus DP, et al. (2019) Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody. Cell
Wingler LM, Elgeti M, Hilger D, et al. (2019) Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations. Cell
Kim J, Grotegut CA, Wisler JW, et al. (2018) β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility. Skeletal Muscle. 8: 39
Luttrell LM, Wang J, Plouffe B, et al. (2018) Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9. Science Signaling. 11
Choi M, Staus DP, Wingler LM, et al. (2018) G protein-coupled receptor kinases (GRKs) orchestrate biased agonism at the β-adrenergic receptor. Science Signaling. 11
Kahsai AW, Pani B, Lefkowitz RJ. (2018) GPCR signaling: conformational activation of arrestins. Cell Research
Wisler JW, Rockman HA, Lefkowitz RJ. (2018) Biased G Protein-Coupled Receptor Signaling: Changing the Paradigm of Drug Discovery. Circulation. 137: 2315-2317
Ahn S, Pani B, Kahsai AW, et al. (2018) Small Molecule Positive Allosteric Modulators of the β-Adrenoceptor Isolated from DNA Encoded Libraries. Molecular Pharmacology
Staus DP, Wingler LM, Choi M, et al. (2018) Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling. Proceedings of the National Academy of Sciences of the United States of America
Smith JS, Lefkowitz RJ, Rajagopal S. (2018) Biased signalling: from simple switches to allosteric microprocessors. Nature Reviews. Drug Discovery
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