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Robert J. Lefkowitz

Affiliations: 
Duke University, Durham, NC 
Area:
G protein-coupled receptors
Website:
http://cardiology.medicine.duke.edu/faculty/details/0096962
Google:
"Robert Lefkowitz"
Bio:

The Nobel Prize in Chemistry 2012 was awarded jointly to Robert J. Lefkowitz and Brian K. Kobilka "for studies of G-protein-coupled receptors"

Mean distance: 13.4 (cluster 11)
 
SNBCP
Cross-listing: Chemistry Tree - Cell Biology Tree

Parents

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Ira Pastan post-doc 1968-1970 NIH
Jesse Roth post-doc 1968-1970 NIH
Edgar Haber post-doc 1970-1973 Harvard Medical School

Children

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Tom Cahill grad student Duke
Henrik G. Dohlman grad student Duke University / HHMI (Physics Tree)
Anthony Nguyen grad student Duke
Robert W. Walters grad student Duke
Seungkirl Ahn grad student 2002 Duke
Alberuni M. Zamah grad student 2002 Duke
Christopher D Nelson grad student 2002-2007 Duke
Kelly N. Nobles grad student 2010 Duke
Minjung Choi grad student 2012-2018 Duke
Jeffrey Arriza post-doc Duke
Minjung Choi post-doc Duke
Susanna Cotecchia post-doc Duke
Kenneth Dickinson post-doc Duke
Dan Houtz post-doc Duke
Guido Iaccarino post-doc Duke
Walter Koch post-doc Duke
Trudy Kohout post-doc Duke
Madan Kwatra post-doc Duke
Frederik Leeb-Lundberg post-doc Duke
Wulfing Lorenz post-doc Duke
Martin Opperman post-doc Duke
Natalia Pakharukova post-doc Duke
Karsten Peppel post-doc Duke
Nadeem Rahman post-doc Duke
Michael Raisch post-doc Duke
Xiu-Rong Ren post-doc Duke
Neil Roth post-doc Duke
Mika Scheinin post-doc Duke
Ruth Strasser post-doc Duke
Berta Strulovici post-doc Duke
Michael Tharp post-doc Duke
Alex Thomsen post-doc Duke
Akira Tohgo post-doc Duke
Vivek Upadhyay post-doc Duke
Johnathan Violin post-doc Duke
Michael Wessels post-doc Duke
Jarl Wikberg post-doc Duke
Kevin Xiao post-doc Duke
Takaaki Yoshimasa post-doc Duke
Daniel Stroik post-doc Duke
Shahab Akhter post-doc Duke
R. Wayne Alexander post-doc Duke
Lee Allen post-doc Duke
Haavard Attramadal post-doc Duke
William G. Barnes post-doc Duke
Jeffrey L. Benovic post-doc Duke (Cell Biology Tree)
Tim Van Biesen post-doc Duke
Nanette H. Bishopric post-doc Duke (Cell Biology Tree)
Jeremy T. Blitzer post-doc Duke (FlyTree)
Mark Bolanowski post-doc Duke
Erin Bressler post-doc Duke
Margaret Briggs-Gowan post-doc Duke
Ernst Burgisser post-doc Duke
Sheng Cai post-doc Duke
Paul G. Campbell post-doc Duke (Literature Tree)
Mei Wang Casey post-doc Duke
Arnab K. Chatterjee post-doc Duke (Chemistry Tree)
Minyong Chen post-doc Duke (Chemistry Tree)
Jing Ruth Chen post-doc Duke
Wei Chen post-doc Duke (Physics Tree)
Yishan Cheng post-doc Duke
Audrey Claing post-doc Duke
William T. Clarke post-doc Duke
Sheila Collins post-doc Duke
Mei Cong post-doc Duke
Yehia Daaka post-doc Duke University School of Medicine (Chemistry Tree)
Laura Davidson post-doc Duke
Albert S. Davies post-doc Duke (MathTree)
Andre DeLean post-doc Duke
Scott M. DeWire post-doc Duke (Microtree)
Matthew T. Drake post-doc Duke (Chemistry Tree)
Mark Drazner post-doc Duke
David M. Feldman post-doc Duke
Mark Fereshteh post-doc Duke
Michael E. Field post-doc Duke
Zoey Fredericks post-doc Duke
Neil Freedman post-doc Duke
Jennifer Freedman post-doc Duke
Tom Frielle post-doc Duke
Tiffany Garrison post-doc Duke
Diane GetsyPalmer post-doc Duke
Larry Goldstein post-doc Duke (FlyTree)
Thomas Gore post-doc Duke
Emily M. Harris post-doc Duke
William Hausdorff post-doc Duke
Brian Hawes post-doc Duke
James Heinsimer post-doc Duke
Mark Hnatowich post-doc Duke
Brian Jeffrey Hoffman post-doc Duke (Chemistry Tree)
Liaoyuan Hu post-doc Duke
Liyin Huang post-doc Duke
Christopher D. Ingersoll post-doc Duke (Biomechanics Tree)
Richard Kent post-doc Duke (Biomechanics Tree)
Khuda Dad Khan post-doc Duke
Klim King post-doc Duke
Michael Kjelsberg post-doc Duke
Andrew Kleist post-doc Duke
Bjoern Klink post-doc Duke
Jeffrey J. Kovacs post-doc Duke
Kathleen Krueger post-doc Duke (SocTree)
Hitoshi Kurose post-doc Duke
Richard Lebovitz post-doc Duke
Stephen B. Liggett post-doc Duke (Cell Biology Tree)
Fannie Lin post-doc Duke
Yuan Lin post-doc Duke (Physics Tree)
Mathew Lo post-doc Duke
Jon Lomasney post-doc Duke
Louis Luttrell post-doc Duke (Cell Biology Tree)
Sandy Macrae post-doc Duke
Negin P. Martin post-doc Duke (Chemistry Tree)
Ali Masoudi post-doc Duke (Physics Tree)
Hiroyaki Matsui post-doc Duke
Stuart Maudsley post-doc Duke
Federico Mayor post-doc Duke
Patsy McDonald post-doc Duke
Thomas Michel post-doc Duke
John Mickey post-doc Duke
Carmelo Milano post-doc Duke
William E. Miller post-doc Duke
Debra Mullikin-Kilpatrick post-doc Duke
Hiroyasu Nakata post-doc Duke
Ponnal Nambi post-doc Duke
Canan Nebigil post-doc Duke
Chris Nelson post-doc Duke
Kurt D. Newman post-doc Duke (Pediatric Surgery Tree)
Brian F. O'Dowd post-doc Duke
Lina M. Obeid post-doc Duke (MathTree)
James Onorato post-doc Duke
Biswaranjan Pani post-doc Duke
Gang Pei post-doc Duke
Steve Perry post-doc Duke (Chemistry Tree)
Kristen J. Pierce post-doc Duke (ID Tree)
Linda J. Pike post-doc Duke (Chemistry Tree)
Julie Pitcher post-doc Duke
Steve Plonk post-doc Duke
Tom Povsic post-doc Duke
Keshava Rajagopal post-doc Duke (Cell Biology Tree)
Sudar Rajagopal post-doc Duke
John C. Raymond post-doc Duke (Physics Tree)
John W. Regan post-doc Duke
Rosana Reis post-doc Duke
Eric Reiter post-doc Duke
Greg Della Rocca post-doc Duke
Greg Sabo post-doc Duke
Philippe Samama post-doc Duke
Douglas Schocken post-doc Duke
Debra A. Schwinn post-doc Duke
Sudha K. Shenoy post-doc Duke
Robert Shorr post-doc Duke
Arun K. Shukla post-doc Duke
Robert F. Spurney post-doc Duke
Dean Staus post-doc Duke
Gary L. Stiles post-doc Duke
Robert Stoffel post-doc Duke
Carl Stone post-doc Duke
Ryan Strachan post-doc Duke
Cathy Strader post-doc Duke
Jinpeng Sun post-doc Duke
Robert L. Tate post-doc Duke (Microtree)
Blossom Tewelde post-doc Duke
Kazushige Touhara post-doc Duke
Bie Shung Tsai post-doc Duke
Ron D. Vale post-doc Duke (Cell Biology Tree)
Huijun Wei post-doc Duke (Chemistry Tree)
Erin J. Whalen post-doc Duke
R. Sanders Williams post-doc Duke
Lewis T. Williams post-doc Duke
Laura M. Wingler post-doc Duke (Chemistry Tree)
Dennis Scott Witherow post-doc Duke (Cell Biology Tree)
Helen Yao post-doc Duke
Musa Zamah post-doc Duke
Yunxiang Zang post-doc Duke
Dave Zidar post-doc Duke
Marc Caron post-doc 1973-1976 Duke
Lee Limbird post-doc 1973-1978 Duke
Warren J. Strittmatter post-doc 1978-1978 Duke
Richard A. Cerione post-doc 1982-1985 Duke University / HHMI (Chemistry Tree)
David R. Sibley post-doc 1983-1987 Duke
Brian K. Kobilka post-doc 1984-1989 Duke
Michel Bouvier post-doc 1985-1989 Université de Montréal
James Inglese post-doc 1989-1994 Duke
Richard T Premont post-doc 1992-1997 Duke University School of Medicine (Chemistry Tree)
Randy A. Hall post-doc 1996-1999 Duke
Guido Iaccarino post-doc 1996-1999 Duke University / HHMI
David S Feldman post-doc 1997-2000 Duke University / HHMI
Makoto R. Hara post-doc 2006-2012 Duke
Jihee Kim research scientist Duke
Jim Wisler research scientist Duke
Alem Kahsai research scientist Duke (Chemistry Tree)
Martin J. Lohse research scientist Duke University / HHMI
Lindsay Rein research scientist Duke
Jennifer J. Linderman research scientist 1996-1997 Duke
Michael E Rockman research scientist 2009-2010 Duke (Chemistry Tree)

Collaborators

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Abraham White collaborator 1975-1981 Duke (Chemistry Tree)
Bruno Giros collaborator 1992-1994 Duke University Medical Center
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Publications

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Pakharukova N, Masoudi A, Pani B, et al. (2020) Allosteric activation of proto-oncogene kinase Src by GPCR-beta-arrestin complexes. The Journal of Biological Chemistry
Ahn S, Shenoy SK, Luttrell LM, et al. (2020) SnapShot: β-Arrestin Functions. Cell. 182: 1362-1362.e1
McMahon C, Staus DP, Wingler LM, et al. (2020) Synthetic nanobodies as angiotensin receptor blockers. Proceedings of the National Academy of Sciences of the United States of America
Wingler LM, Lefkowitz RJ. (2020) Conformational Basis of G Protein-Coupled Receptor Signaling Versatility. Trends in Cell Biology
Kim J, Grotegut CA, Wisler JW, et al. (2020) The β-arrestin-biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility. Proceedings of the National Academy of Sciences of the United States of America
Manglik A, Wingler LM, Rockman HA, et al. (2020) β-Arrestin-Biased Angiotensin II Receptor Agonists for COVID-19. Circulation
Wingler LM, Skiba MA, McMahon C, et al. (2020) Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR. Science (New York, N.Y.). 367: 888-892
Suomivuori CM, Latorraca NR, Wingler LM, et al. (2020) Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor. Science (New York, N.Y.). 367: 881-887
Staus DP, Hu H, Robertson MJ, et al. (2020) Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc. Nature
Nguyen AH, Thomsen ARB, Cahill TJ, et al. (2019) Structure of an endosomal signaling GPCR-G protein-β-arrestin megacomplex. Nature Structural & Molecular Biology
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