J. Timothy Greenamyre - Publications

University of Pittsburgh, Pittsburgh, PA, United States 
Parkinson's Disease, Huntington's Disease

205 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Van Laar VS, Chen J, Zharikov AD, Bai Q, Di Maio R, Dukes AA, Hastings TG, Watkins SC, Greenamyre JT, St Croix CM, Burton EA. α-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo. Redox Biology. 37: 101695. PMID 32905883 DOI: 10.1016/j.redox.2020.101695  1
2020 De Miranda BR, Greenamyre JT. Trichloroethylene, a ubiquitous environmental contaminant in the risk for Parkinson's disease. Environmental Science. Processes & Impacts. PMID 31996877 DOI: 10.1039/c9em00578a  0.4
2019 Rocha EM, De Miranda BR, Castro S, Drolet R, Hatcher NG, Yao L, Smith SM, Keeney MT, Di Maio R, Kofler J, Hastings TG, Greenamyre JT. LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease. Neurobiology of Disease. 104626. PMID 31618685 DOI: 10.1016/j.nbd.2019.104626  1
2019 De Miranda BR, Greenamyre JT. Response to Rotenone and Parkinson's disease; reduced sensitivity in females. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 31161199 DOI: 10.1093/toxsci/kfz127  0.4
2019 Tapias V, McCoy JL, Greenamyre JT. Phenothiazine normalizes the NADH/NAD ratio, maintains mitochondrial integrity and protects the nigrostriatal dopamine system in a chronic rotenone model of Parkinson's disease. Redox Biology. 24: 101164. PMID 30925294 DOI: 10.1016/j.redox.2019.101164  1
2019 De Miranda BR, Fazzari M, Rocha EM, Castro S, Greenamyre JT. Sex differences in rotenone sensitivity reflect the male-to-female ratio in human Parkinson's disease incidence. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30907971 DOI: 10.1093/toxsci/kfz082  0.44
2019 Espay AJ, Vizcarra JA, Marsili L, Lang AE, Simon DK, Merola A, Josephs KA, Fasano A, Morgante F, Savica R, Greenamyre JT, Cambi F, Yamasaki TR, Tanner CM, Gan-Or Z, et al. Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases. Neurology. 92: 329-337. PMID 30745444 DOI: 10.1212/WNL.0000000000006926  0.36
2018 Di Maio R, Hoffman EK, Rocha EM, Keeney MT, Sanders LH, De Miranda BR, Zharikov A, Van Laar A, Stepan AF, Lanz TA, Kofler JK, Burton EA, Alessi DR, Hastings TG, Greenamyre JT. LRRK2 activation in idiopathic Parkinson's disease. Science Translational Medicine. 10. PMID 30045977 DOI: 10.1126/scitranslmed.aar5429  1
2018 Sanders LH, Rouanet JP, Howlett EH, Leuthner TC, Rooney JP, Greenamyre JT, Meyer JN. Newly Revised Quantitative PCR-Based Assay for Mitochondrial and Nuclear DNA Damage. Current Protocols in Toxicology. 76: e50. PMID 30040241 DOI: 10.1002/cptx.50  1
2018 Van Laar VS, Arnold B, Howlett EH, Calderon MJ, St Croix CM, Greenamyre JT, Sanders LH, Berman SB. Evidence for compartmentalized axonal mitochondrial biogenesis: Mitochondrial DNA replication increases in distal axons as an early response to Parkinson's disease-relevant stress. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30030401 DOI: 10.1523/JNEUROSCI.0541-18.2018  1
2017 Welty S, Teng Y, Liang Z, Zhao W, Sanders L, Greenamyre JT, Rubio ME, Thathiah A, Kodali R, Wetzel R, Levine AS, Lan L. RAD52 is required for RNA-templated recombination repair in post-mitotic neurons. The Journal of Biological Chemistry. PMID 29217771 DOI: 10.1074/jbc.M117.808402  0.32
2017 Howlett EH, Jensen N, Belmonte F, Zafar F, Hu X, Kluss J, Schüle B, Kaufman BA, Greenamyre JT, Sanders LH. LRRK2 G2019S-induced mitochondrial DNA damage is LRRK2 kinase dependent and inhibition restores mtDNA integrity in Parkinson's disease. Human Molecular Genetics. PMID 28973664 DOI: 10.1093/hmg/ddx320  1
2017 Milanese C, Tapias V, Gabriels S, Cerri S, Levandis G, Blandini F, Tresini M, Shiva S, Greenamyre JT, Gladwin MT, Mastroberardino PG. Mitochondrial complex I reversible S-nitrosation improves bioenergetics and is protective in Parkinson's disease. Antioxidants & Redox Signaling. PMID 28816057 DOI: 10.1089/ars.2017.6992  1
2017 Sanders LH, Paul KC, Howlett EH, Lawal H, Boppana S, Bronstein JM, Ritz B, Greenamyre JT. Base excision repair variants and pesticide exposure increase Parkinson's disease risk. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 28460087 DOI: 10.1093/toxsci/kfx086  1
2016 Di Maio R, Barrett PJ, Hoffman EK, Barrett CW, Zharikov A, Borah A, Hu X, McCoy J, Chu CT, Burton EA, Hastings TG, Greenamyre JT. α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease. Science Translational Medicine. 8: 342ra78. PMID 27280685 DOI: 10.1126/scitranslmed.aaf3634  1
2016 Sahoo B, Arduini I, Drombosky KW, Kodali R, Sanders LH, Greenamyre JT, Wetzel R. Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer. Plos One. 11: e0155747. PMID 27271685 DOI: 10.1371/journal.pone.0155747  1
2015 Greenamyre JT, Sanders LH, Gasser T. Fruit flies, bile acids, and Parkinson disease: A mitochondrial connection? Neurology. 85: 838-9. PMID 26253445 DOI: 10.1212/WNL.0000000000001912  1
2015 Zharikov AD, Cannon JR, Tapias V, Bai Q, Horowitz MP, Shah V, El Ayadi A, Hastings TG, Greenamyre JT, Burton EA. shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model. The Journal of Clinical Investigation. PMID 26075822 DOI: 10.1172/JCI64502  1
2015 Tyurina YY, Polimova AM, Maciel E, Tyurin VA, Kapralova VI, Winnica DE, Vikulina AS, Domingues MR, McCoy J, Sanders LH, Bay?r H, Greenamyre JT, Kagan VE. LC/MS analysis of cardiolipins in substantia nigra and plasma of rotenone-treated rats: Implication for mitochondrial dysfunction in Parkinson's disease. Free Radical Research. 49: 681-91. PMID 25740198 DOI: 10.3109/10715762.2015.1005085  1
2015 Rooney JP, Ryde IT, Sanders LH, Howlett EH, Colton MD, Germ KE, Mayer GD, Greenamyre JT, Meyer JN. PCR based determination of mitochondrial DNA copy number in multiple species. Methods in Molecular Biology (Clifton, N.J.). 1241: 23-38. PMID 25308485 DOI: 10.1007/978-1-4939-1875-1_3  1
2015 Lee JW, Tapias V, Di Maio R, Greenamyre JT, Cannon JR. Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats. Neurobiology of Aging. 36: 505-18. PMID 25174649 DOI: 10.1016/j.neurobiolaging.2014.07.011  1
2015 Greenamyre JT, Barrett P. Genetic Factors in Environmentally Induced Disease Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders. 21-43. DOI: 10.1016/B978-0-12-800228-5.00002-9  1
2014 Di Maio R, Cannon JR, Timothy Greenamyre J. Post-status epilepticus treatment with the cannabinoid agonist WIN 55,212-2 prevents chronic epileptic hippocampal damage in rats. Neurobiology of Disease. 73: 356-365. PMID 25447228 DOI: 10.1016/j.nbd.2014.10.018  0.84
2014 Sanders LH, Howlett EH, McCoy J, Greenamyre JT. Mitochondrial DNA damage as a peripheral biomarker for mitochondrial toxin exposure in rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 142: 395-402. PMID 25237061 DOI: 10.1093/toxsci/kfu185  1
2014 Sanders LH, McCoy J, Hu X, Mastroberardino PG, Dickinson BC, Chang CJ, Chu CT, Van Houten B, Greenamyre JT. Mitochondrial DNA damage: molecular marker of vulnerable nigral neurons in Parkinson's disease. Neurobiology of Disease. 70: 214-23. PMID 24981012 DOI: 10.1016/j.nbd.2014.06.014  1
2014 Schapira AH, Olanow CW, Greenamyre JT, Bezard E. Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives. Lancet (London, England). 384: 545-55. PMID 24954676 DOI: 10.1016/S0140-6736(14)61010-2  1
2014 Tapias V, Greenamyre JT. A rapid and sensitive automated image-based approach for in vitro and in vivo characterization of cell morphology and quantification of cell number and neurite architecture. Current Protocols in Cytometry / Editorial Board, J. Paul Robinson, Managing Editor ... [Et Al.]. 68: 12.33.1-12.33.22. PMID 24692056 DOI: 10.1002/0471142956.cy1233s68  1
2014 Tapias V, Cannon JR, Greenamyre JT. Pomegranate juice exacerbates oxidative stress and nigrostriatal degeneration in Parkinson's disease. Neurobiology of Aging. 35: 1162-76. PMID 24315037 DOI: 10.1016/j.neurobiolaging.2013.10.077  1
2014 Sanders LH, Laganière J, Cooper O, Mak SK, Vu BJ, Huang YA, Paschon DE, Vangipuram M, Sundararajan R, Urnov FD, Langston JW, Gregory PD, Zhang HS, Greenamyre JT, Isacson O, et al. LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction. Neurobiology of Disease. 62: 381-6. PMID 24148854 DOI: 10.1016/j.nbd.2013.10.013  1
2013 Sanders LH, Greenamyre JT. Oxidative damage to macromolecules in human Parkinson disease and the rotenone model. Free Radical Biology & Medicine. 62: 111-20. PMID 23328732 DOI: 10.1016/j.freeradbiomed.2013.01.003  1
2013 Tapias V, Greenamyre JT, Watkins SC. Automated imaging system for fast quantitation of neurons, cell morphology and neurite morphometry in vivo and in vitro. Neurobiology of Disease. 54: 158-68. PMID 23220621 DOI: 10.1016/j.nbd.2012.11.018  1
2013 Cannon JR, Geghman KD, Tapias V, Sew T, Dail MK, Li C, Greenamyre JT. Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment. Experimental Neurology. 240: 44-56. PMID 23153578 DOI: 10.1016/j.expneurol.2012.11.007  1
2013 Mullett SJ, Di Maio R, Greenamyre JT, Hinkle DA. DJ-1 expression modulates astrocyte-mediated protection against neuronal oxidative stress. Journal of Molecular Neuroscience : Mn. 49: 507-11. PMID 23065353 DOI: 10.1007/s12031-012-9904-4  1
2013 Di Maio R, Mastroberardino PG, Hu X, Montero LM, Greenamyre JT. Thiol oxidation and altered NR2B/NMDA receptor functions in in vitro and in vivo pilocarpine models: implications for epileptogenesis. Neurobiology of Disease. 49: 87-98. PMID 22824136 DOI: 10.1016/j.nbd.2012.07.013  1
2013 Cannon JR, Greenamyre JT. Gene-environment interactions in Parkinson's disease: specific evidence in humans and mammalian models. Neurobiology of Disease. 57: 38-46. PMID 22776331 DOI: 10.1016/j.nbd.2012.06.025  1
2013 Greenamyre JT, Cannon JR, Sanders LH, Tapias V, Bai Q, Volpicelli-Daley L, Lee VM, Burton EA. Synuclein-Mitochondrial Interactions in Substantia Nigra Dopamine Neurons Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012. 126-127. DOI: 10.1016/B978-0-12-800044-1.00111-2  1
2012 Muñoz P, Paris I, Sanders LH, Greenamyre JT, Segura-Aguilar J. Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity. Biochimica Et Biophysica Acta. 1822: 1125-36. PMID 22483869 DOI: 10.1016/j.bbadis.2012.03.010  1
2012 Milanese C, Sager JJ, Bai Q, Farrell TC, Cannon JR, Greenamyre JT, Burton EA. Hypokinesia and reduced dopamine levels in zebrafish lacking β- and γ1-synucleins. The Journal of Biological Chemistry. 287: 2971-83. PMID 22128150 DOI: 10.1074/jbc.M111.308312  1
2012 Martinez TN, Greenamyre JT. Toxin models of mitochondrial dysfunction in Parkinson's disease. Antioxidants & Redox Signaling. 16: 920-34. PMID 21554057 DOI: 10.1089/ars.2011.4033  1
2011 Sanders LH, Greenamyre JT. Regulation of complex I by Engrailed is complex too. Nature Neuroscience. 14: 1221-2. PMID 21952262 DOI: 10.1038/nn.2939  1
2011 Cannon JR, Greenamyre JT. The role of environmental exposures in neurodegeneration and neurodegenerative diseases. Toxicological Sciences : An Official Journal of the Society of Toxicology. 124: 225-50. PMID 21914720 DOI: 10.1093/toxsci/kfr239  1
2011 Jain S, Siegle GJ, Gu C, Moore CG, Ivanco LS, Studenski S, Greenamyre JT, Steinhauer SR. Pupillary unrest correlates with arousal symptoms and motor signs in Parkinson disease. Movement Disorders : Official Journal of the Movement Disorder Society. 26: 1344-7. PMID 21506163 DOI: 10.1002/mds.23628  1
2011 D'Aiuto L, Di Maio R, Mohan KN, Minervini C, Saporiti F, Soreca I, Greenamyre JT, Chaillet JR. Mouse ES cells overexpressing DNMT1 produce abnormal neurons with upregulated NMDA/NR1 subunit. Differentiation; Research in Biological Diversity. 82: 9-17. PMID 21492995 DOI: 10.1016/j.diff.2011.03.003  1
2011 Paris I, Muñoz P, Huenchuguala S, Couve E, Sanders LH, Greenamyre JT, Caviedes P, Segura-Aguilar J. Autophagy protects against aminochrome-induced cell death in substantia nigra-derived cell line. Toxicological Sciences : An Official Journal of the Society of Toxicology. 121: 376-88. PMID 21427056 DOI: 10.1093/toxsci/kfr060  1
2011 Di Maio R, Mastroberardino PG, Hu X, Montero L, Greenamyre JT. Pilocapine alters NMDA receptor expression and function in hippocampal neurons: NADPH oxidase and ERK1/2 mechanisms. Neurobiology of Disease. 42: 482-95. PMID 21397025 DOI: 10.1016/j.nbd.2011.02.012  1
2011 Horowitz MP, Milanese C, Di Maio R, Hu X, Montero LM, Sanders LH, Tapias V, Sepe S, van Cappellen WA, Burton EA, Greenamyre JT, Mastroberardino PG. Single-cell redox imaging demonstrates a distinctive response of dopaminergic neurons to oxidative insults. Antioxidants & Redox Signaling. 15: 855-71. PMID 21395478 DOI: 10.1089/ars.2010.3629  1
2011 Hu X, Weng Z, Chu CT, Zhang L, Cao G, Gao Y, Signore A, Zhu J, Hastings T, Greenamyre JT, Chen J. Peroxiredoxin-2 protects against 6-hydroxydopamine-induced dopaminergic neurodegeneration via attenuation of the apoptosis signal-regulating kinase (ASK1) signaling cascade. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 247-61. PMID 21209210 DOI: 10.1523/JNEUROSCI.4589-10.2011  1
2011 Jain S, Siegle GJ, Gu C, Moore CG, Ivanco LS, Jennings JR, Steinhauer SR, Studenski S, Greenamyre JT. Autonomic insufficiency in pupillary and cardiovascular systems in Parkinson's disease. Parkinsonism & Related Disorders. 17: 119-22. PMID 21115264 DOI: 10.1016/j.parkreldis.2010.11.005  1
2011 Cannon JR, Sew T, Montero L, Burton EA, Greenamyre JT. Pseudotype-dependent lentiviral transduction of astrocytes or neurons in the rat substantia nigra. Experimental Neurology. 228: 41-52. PMID 21056560 DOI: 10.1016/j.expneurol.2010.10.016  1
2010 Cannon JR, Greenamyre JT. Neurotoxic in vivo models of Parkinson's disease recent advances. Progress in Brain Research. 184: 17-33. PMID 20887868 DOI: 10.1016/S0079-6123(10)84002-6  1
2010 Horowitz MP, Greenamyre JT. Gene-environment interactions in Parkinson's disease: the importance of animal modeling. Clinical Pharmacology and Therapeutics. 88: 467-74. PMID 20811350 DOI: 10.1038/clpt.2010.138  1
2010 Horowitz MP, Greenamyre JT. Mitochondrial iron metabolism and its role in neurodegeneration. Journal of Alzheimer's Disease : Jad. 20: S551-68. PMID 20463401 DOI: 10.3233/JAD-2010-100354  1
2010 Greene JG, Dingledine R, Greenamyre JT. Neuron-selective changes in RNA transcripts related to energy metabolism in toxic models of parkinsonism in rodents. Neurobiology of Disease. 38: 476-81. PMID 20307667 DOI: 10.1016/j.nbd.2010.03.014  1
2010 Greenamyre JT, Cannon JR, Drolet R, Mastroberardino PG. Lessons from the rotenone model of Parkinson's disease. Trends in Pharmacological Sciences. 31: 141-2; author reply . PMID 20096940 DOI: 10.1016/j.tips.2009.12.006  1
2010 Tapias V, Cannon JR, Greenamyre JT. Melatonin treatment potentiates neurodegeneration in a rat rotenone Parkinson's disease model. Journal of Neuroscience Research. 88: 420-7. PMID 19681169 DOI: 10.1002/jnr.22201  1
2009 Cannon JR, Greenamyre JT. NeuN is not a reliable marker of dopamine neurons in rat substantia nigra. Neuroscience Letters. 464: 14-7. PMID 19682546 DOI: 10.1016/j.neulet.2009.08.023  1
2009 Drolet RE, Cannon JR, Montero L, Greenamyre JT. Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology. Neurobiology of Disease. 36: 96-102. PMID 19595768 DOI: 10.1016/j.nbd.2009.06.017  1
2009 Cannon JR, Tapias V, Na HM, Honick AS, Drolet RE, Greenamyre JT. A highly reproducible rotenone model of Parkinson's disease. Neurobiology of Disease. 34: 279-90. PMID 19385059 DOI: 10.1016/j.nbd.2009.01.016  1
2009 Bayir H, Kapralov AA, Jiang J, Huang Z, Tyurina YY, Tyurin VA, Zhao Q, Belikova NA, Vlasova II, Maeda A, Zhu J, Na HM, Mastroberardino PG, Sparvero LJ, Amoscato AA, ... ... Greenamyre JT, et al. Peroxidase mechanism of lipid-dependent cross-linking of synuclein with cytochrome C: protection against apoptosis versus delayed oxidative stress in Parkinson disease. The Journal of Biological Chemistry. 284: 15951-69. PMID 19351880 DOI: 10.1074/jbc.M900418200  1
2009 Mastroberardino PG, Hoffman EK, Horowitz MP, Betarbet R, Taylor G, Cheng D, Na HM, Gutekunst CA, Gearing M, Trojanowski JQ, Anderson M, Chu CT, Peng J, Greenamyre JT. A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease. Neurobiology of Disease. 34: 417-31. PMID 19250966 DOI: 10.1016/j.nbd.2009.02.009  1
2009 Saper CB, Maunsell JHR, Destexhe A, Richmond B, Campagnoni A, Sarter M, Fritschy JM, Bloom FE, Perry G, Smith MA, Ascoli G, Kennedy D, De Schutter E, Eichenbaum H, Greenamyre JT, et al. The neuroscience peer review consortium Journal of Neuroscience. 29: 1255-1256. PMID 19193872  1
2008 Mastroberardino PG, Orr AL, Hu X, Na HM, Greenamyre JT. A FRET-based method to study protein thiol oxidation in histological preparations. Free Radical Biology & Medicine. 45: 971-81. PMID 18620047 DOI: 10.1016/j.freeradbiomed.2008.06.018  1
2008 Orr AL, Li S, Wang CE, Li H, Wang J, Rong J, Xu X, Mastroberardino PG, Greenamyre JT, Li XJ. N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 2783-92. PMID 18337408 DOI: 10.1523/JNEUROSCI.0106-08.2008  1
2008 Marella M, Seo BB, Nakamaru-Ogiso E, Greenamyre JT, Matsuno-Yagi A, Yagi T. Protection by the NDI1 gene against neurodegeneration in a rotenone rat model of Parkinson's disease. Plos One. 3: e1433. PMID 18197244 DOI: 10.1371/journal.pone.0001433  1
2008 Greene JG, Greenamyre JT, Dingledine R. Sequential and concerted gene expression changes in a chronic in vitro model of parkinsonism. Neuroscience. 152: 198-207. PMID 18191903 DOI: 10.1016/j.neuroscience.2007.11.029  1
2008 Betarbet R, Greenamyre JT. Complex I Inhibition, Rotenone and Parkinson's Disease Parkinson's Disease. 195-206. DOI: 10.1016/B978-0-12-374028-1.00014-2  1
2007 Betarbet R, Greenamyre JT. Parkinson's disease: animal models. Handbook of Clinical Neurology. 83: 265-87. PMID 18808918 DOI: 10.1016/S0072-9752(07)83011-9  1
2007 Greenamyre JT. Huntington's disease: getting closer. The American Journal of Psychiatry. 164: 1318. PMID 17728414 DOI: 10.1176/appi.ajp.2007.07071201  1
2007 Cao X, Liang L, Hadcock JR, Iredale PA, Griffith DA, Menniti FS, Factor S, Greenamyre JT, Papa SM. Blockade of cannabinoid type 1 receptors augments the antiparkinsonian action of levodopa without affecting dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 323: 318-26. PMID 17630359 DOI: 10.1124/jpet.107.125666  1
2007 Langbehn DR, Paulsen JS. Predictors of diagnosis in Huntington disease. Neurology. 68: 1710-7. PMID 17502553 DOI: 10.1212/01.wnl.0000261918.90053.96  1
2007 Greenamyre JT. Huntington's disease--making connections. The New England Journal of Medicine. 356: 518-20. PMID 17267914 DOI: 10.1056/NEJMcibr067022  1
2007 Sherer TB, Richardson JR, Testa CM, Seo BB, Panov AV, Yagi T, Matsuno-Yagi A, Miller GW, Greenamyre JT. Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's disease. Journal of Neurochemistry. 100: 1469-79. PMID 17241123 DOI: 10.1111/j.1471-4159.2006.04333.x  1
2007 Panov A, Dikalov S, Shalbuyeva N, Hemendinger R, Greenamyre JT, Rosenfeld J. Species- and tissue-specific relationships between mitochondrial permeability transition and generation of ROS in brain and liver mitochondria of rats and mice. American Journal of Physiology. Cell Physiology. 292: C708-18. PMID 17050617 DOI: 10.1152/ajpcell.00202.2006  1
2007 Richardson JR, Caudle WM, Guillot TS, Watson JL, Nakamaru-Ogiso E, Seo BB, Sherer TB, Greenamyre JT, Yagi T, Matsuno-Yagi A, Miller GW. Obligatory role for complex I inhibition in the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Toxicological Sciences : An Official Journal of the Society of Toxicology. 95: 196-204. PMID 17038483 DOI: 10.1093/toxsci/kfl133  1
2007 Greenamyre JT. Growth, impact factor and change at Neurobiology of Disease Neurobiology of Disease. 28: 1-2. DOI: 10.1016/j.nbd.2007.07.025  1
2006 Berman SB, Greenamyre JT. Update on Huntington's disease. Current Neurology and Neuroscience Reports. 6: 281-6. PMID 16822347 DOI: 10.1007/s11910-006-0019-6  1
2006 Pallanck L, Greenamyre JT. Neurodegenerative disease: pink, parkin and the brain. Nature. 441: 1058. PMID 16810237 DOI: 10.1038/4411058a  1
2006 Chen Y, Yu M, Jones DP, Greenamyre JT, Cai J. Protection against oxidant-induced apoptosis by mitochondrial thioredoxin in SH-SY5Y neuroblastoma cells. Toxicology and Applied Pharmacology. 216: 256-62. PMID 16797630 DOI: 10.1016/j.taap.2006.05.006  1
2006 Betarbet R, Canet-Aviles RM, Sherer TB, Mastroberardino PG, McLendon C, Kim JH, Lund S, Na HM, Taylor G, Bence NF, Kopito R, Seo BB, Yagi T, Yagi A, Klinefelter G, ... ... Greenamyre JT, et al. Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system. Neurobiology of Disease. 22: 404-20. PMID 16439141 DOI: 10.1016/j.nbd.2005.12.003  1
2005 Panov A, Dikalov S, Shalbuyeva N, Taylor G, Sherer T, Greenamyre JT. Rotenone model of Parkinson disease: multiple brain mitochondria dysfunctions after short term systemic rotenone intoxication. The Journal of Biological Chemistry. 280: 42026-35. PMID 16243845 DOI: 10.1074/jbc.M508628200  1
2005 Richardson JR, Quan Y, Sherer TB, Greenamyre JT, Miller GW. Paraquat neurotoxicity is distinct from that of MPTP and rotenone. Toxicological Sciences : An Official Journal of the Society of Toxicology. 88: 193-201. PMID 16141438 DOI: 10.1093/toxsci/kfi304  1
2005 Puri BK, Leavitt BR, Hayden MR, Ross CA, Rosenblatt A, Greenamyre JT, Hersch S, Vaddadi KS, Sword A, Horrobin DF, Manku M, Murck H. Ethyl-EPA in Huntington disease: a double-blind, randomized, placebo-controlled trial. Neurology. 65: 286-92. PMID 16043801 DOI: 10.1212/01.wnl.0000169025.09670.6d  1
2005 Sherer TB, Greenamyre JT. Oxidative damage in Parkinson's disease. Antioxidants & Redox Signaling. 7: 627-9. PMID 15890006 DOI: 10.1089/ars.2005.7.627  1
2005 Testa CM, Sherer TB, Greenamyre JT. Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures. Brain Research. Molecular Brain Research. 134: 109-18. PMID 15790535 DOI: 10.1016/j.molbrainres.2004.11.007  1
2005 Panov AV, Lund S, Greenamyre JT. Ca2+-induced permeability transition in human lymphoblastoid cell mitochondria from normal and Huntington's disease individuals. Molecular and Cellular Biochemistry. 269: 143-52. PMID 15786727 DOI: 10.1007/s11010-005-3454-9  1
2005 Greene JG, Dingledine R, Greenamyre JT. Gene expression profiling of rat midbrain dopamine neurons: implications for selective vulnerability in parkinsonism. Neurobiology of Disease. 18: 19-31. PMID 15649693 DOI: 10.1016/j.nbd.2004.10.003  1
2005 Betarbet R, Sherer TB, Greenamyre JT. Ubiquitin-proteasome system and Parkinson's diseases. Experimental Neurology. 191: S17-27. PMID 15629758 DOI: 10.1016/j.expneurol.2004.08.021  1
2005 Greene JG, Greenamyre JT. Mitochondria, metabolic inhibitors and neurodegeneration Neurodegenerative Diseases: Neurobiology, Pathogenesis and Therapeutics. 33-43. DOI: 10.1017/CBO9780511544873.004  1
2005 Greenamyre JT, Gilman S. Neurobiology of Disease: Editorial Neurobiology of Disease. 18: 1. DOI: 10.1016/j.nbd.2004.09.020  1
2005 Sherer TB, Betarbet R, Greenamyre JT. Rotenone rat and other neurotoxin models of parkinson disease Movement Disorders. 161-172. DOI: 10.1016/B978-012088382-0/50013-X  1
2004 Caboni P, Sherer TB, Zhang N, Taylor G, Na HM, Greenamyre JT, Casida JE. Rotenone, deguelin, their metabolites, and the rat model of Parkinson's disease. Chemical Research in Toxicology. 17: 1540-8. PMID 15540952 DOI: 10.1021/tx049867r  1
2004 Papa SM, Auberson YP, Greenamyre JT. Prolongation of levodopa responses by glycineB antagonists in parkinsonian primates. Annals of Neurology. 56: 723-7. PMID 15470750 DOI: 10.1002/ana.20279  1
2004 Betarbet R, Greenamyre JT. Regulation of dopamine receptor and neuropeptide expression in the basal ganglia of monkeys treated with MPTP. Experimental Neurology. 189: 393-403. PMID 15380489 DOI: 10.1016/j.expneurol.2004.05.041  1
2004 Soares J, Kliem MA, Betarbet R, Greenamyre JT, Yamamoto B, Wichmann T. Role of external pallidal segment in primate parkinsonism: comparison of the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism and lesions of the external pallidal segment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 6417-26. PMID 15269251 DOI: 10.1523/JNEUROSCI.0836-04.2004  1
2004 Greenamyre JT, Hastings TG. Biomedicine. Parkinson's--divergent causes, convergent mechanisms. Science (New York, N.Y.). 304: 1120-2. PMID 15155938 DOI: 10.1126/science.1098966  1
2004 Betarbet R, Poisik O, Sherer TB, Greenamyre JT. Differential expression and ser897 phosphorylation of striatal N-methyl-d-aspartate receptor subunit NR1 in animal models of Parkinson's disease. Experimental Neurology. 187: 76-85. PMID 15081590 DOI: 10.1016/j.expneurol.2003.12.012  1
2004 Panov AV, Andreeva L, Greenamyre JT. Quantitative evaluation of the effects of mitochondrial permeability transition pore modifiers on accumulation of calcium phosphate: comparison of rat liver and brain mitochondria. Archives of Biochemistry and Biophysics. 424: 44-52. PMID 15019835 DOI: 10.1016/j.abb.2004.01.013  1
2003 Sherer TB, Betarbet R, Testa CM, Seo BB, Richardson JR, Kim JH, Miller GW, Yagi T, Matsuno-Yagi A, Greenamyre JT. Mechanism of toxicity in rotenone models of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 10756-64. PMID 14645467  1
2003 Greenamyre JT, Betarbet R, Sherer TB. The rotenone model of Parkinson's disease: genes, environment and mitochondria. Parkinsonism & Related Disorders. 9: S59-64. PMID 12915069 DOI: 10.1016/S1353-8020(03)00023-3  1
2003 Sherer TB, Betarbet R, Kim JH, Greenamyre JT. Selective microglial activation in the rat rotenone model of Parkinson's disease. Neuroscience Letters. 341: 87-90. PMID 12686372 DOI: 10.1016/S0304-3940(03)00172-1  1
2003 Wheelock VL, Tempkin T, Marder K, Nance M, Myers RH, Zhao H, Kayson E, Orme C, Shoulson I. Predictors of nursing home placement in Huntington disease. Neurology. 60: 998-1001. PMID 12654967 DOI: 10.1212/01.WNL.0000052992.58107.67  1
2003 Panov AV, Burke JR, Strittmatter WJ, Greenamyre JT. In vitro effects of polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Huntington's disease. Archives of Biochemistry and Biophysics. 410: 1-6. PMID 12559971 DOI: 10.1016/S0003-9861(02)00585-4  1
2003 Sherer TB, Kim JH, Betarbet R, Greenamyre JT. Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation. Experimental Neurology. 179: 9-16. PMID 12504863 DOI: 10.1006/exnr.2002.8072  1
2002 Stephans SE, Miller GW, Levey AI, Greenamyre JT. Acute mitochondrial and chronic toxicological effects of 1-methyl-4-phenylpyridinium in human neuroblastoma cells. Neurotoxicology. 23: 569-80. PMID 12428729 DOI: 10.1016/S0161-813X(02)00060-8  1
2002 Betarbet R, Sherer TB, Di Monte DA, Greenamyre JT. Mechanistic approaches to Parkinson's disease pathogenesis. Brain Pathology (Zurich, Switzerland). 12: 499-510. PMID 12408237  1
2002 Sherer TB, Betarbet R, Stout AK, Lund S, Baptista M, Panov AV, Cookson MR, Greenamyre JT. An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 7006-15. PMID 12177198  1
2002 Panov AV, Gutekunst CA, Leavitt BR, Hayden MR, Burke JR, Strittmatter WJ, Greenamyre JT. Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines. Nature Neuroscience. 5: 731-6. PMID 12089530 DOI: 10.1038/nn884  1
2002 Sherer TB, Betarbet R, Greenamyre JT. Environment, mitochondria, and Parkinson's disease. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 8: 192-7. PMID 12061498  1
2002 Betarbet R, Sherer TB, Greenamyre JT. Animal models of Parkinson's disease. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 24: 308-18. PMID 11948617 DOI: 10.1002/bies.10067  1
2002 Greenamyre JT, Shoulson I. We need something better, and we need it now: fetal striatal transplantation in Huntington's disease? Neurology. 58: 675-6. PMID 11889226  1
2001 Sherer TB, Betarbet R, Greenamyre JT. Pesticides and Parkinson's disease. Thescientificworldjournal. 1: 207-8. PMID 12805673 DOI: 10.1100/tsw.2001.35  1
2001 Greenamyre JT, Sherer TB, Betarbet R, Panov AV. Complex I and Parkinson's disease. Iubmb Life. 52: 135-41. PMID 11798025 DOI: 10.1080/15216540152845939  1
2001 Sherer TB, Betarbet R, Greenamyre JT. Pathogenesis of Parkinson's disease. Current Opinion in Investigational Drugs (London, England : 2000). 2: 657-62. PMID 11569943  1
2001 Blandini F, Greenamyre JT, Fancellu R, Nappi G. Blockade of subthalamic glutamatergic activity corrects changes in neuronal metabolism and motor behavior in rats with nigrostriatal lesions. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 22: 49-50. PMID 11487196 DOI: 10.1007/s100720170041  1
2001 Simon DK, Tarnopolsky MA, Greenamyre JT, Johns DR. A frameshift mitochondrial complex I gene mutation in a patient with dystonia and cataracts: is the mutation pathogenic? Journal of Medical Genetics. 38: 58-61. PMID 11332403 DOI: 10.1136/jmg.38.1.58  1
2001 Blandini F, Nappi G, Greenamyre JT. Subthalamic infusion of an NMDA antagonist prevents basal ganglia metabolic changes and nigral degeneration in a rodent model of Parkinson's disease. Annals of Neurology. 49: 525-9. PMID 11310632  0.32
2001 Greenamyre JT. Glutamatergic influences on the basal ganglia. Clinical Neuropharmacology. 24: 65-70. PMID 11307040 DOI: 10.1097/00002826-200103000-00001  1
2001 Shoulson I, Penney J, McDermott M, Schwid S, Kayson E, Chase T, Fahn S, Greenamyre JT, Lang A, Siderowf A, Pearson N, Harrison M, Rost E, Colcher A, Lloyd M, et al. A randomized, controlled trial of remacemide for motor fluctuations in Parkinson's disease. Neurology. 56: 455-62. PMID 11222787  0.56
2001 Greenamyre JT, Betarbet R, Sherer T, Panov A. Response: Parkinson's disease, pesticides and mitochondrial dysfunction Trends in Neurosciences. 24: 247. DOI: 10.1016/S0166-2236(00)01788-4  1
2000 Sherer T, Greenamyre JT. A therapeutic target and biomarker in Friedreich's ataxia. Neurology. 55: 1600-1. PMID 11113210  1
2000 Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nature Neuroscience. 3: 1301-6. PMID 11100151 DOI: 10.1038/81834  1
2000 Talpade DJ, Greene JG, Higgins DS, Greenamyre JT. In vivo labeling of mitochondrial complex I (NADH:ubiquinone oxidoreductase) in rat brain using [(3)H]dihydrorotenone. Journal of Neurochemistry. 75: 2611-21. PMID 11080215 DOI: 10.1046/j.1471-4159.2000.0752611.x  1
2000 Greenamyre JT. "Ottorino Rossi" Award 2000. New targets for therapy in Parkinson's disease: pathogenesis and pathophysiology. Functional Neurology. 15: 67-80. PMID 10916718  1
2000 Pettus EH, Betarbet R, Cottrell B, Wallace DC, Madyastha V, Greenamyre JT. Immunocytochemical characterization of the mitochondrially encoded ND1 subunit of complex I (NADH : ubiquinone oxidoreductase) in rat brain. Journal of Neurochemistry. 75: 383-92. PMID 10854284 DOI: 10.1046/j.1471-4159.2000.0750383.x  1
2000 Jha N, Jurma O, Lalli G, Liu Y, Pettus EH, Greenamyre JT, Liu RM, Forman HJ, Andersen JK. Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease. The Journal of Biological Chemistry. 275: 26096-101. PMID 10846169 DOI: 10.1074/jbc.M000120200  1
2000 Steece-Collier K, Chambers LK, Jaw-Tsai SS, Menniti FS, Greenamyre JT. Antiparkinsonian actions of CP-101,606, an antagonist of NR2B subunit-containing N-methyl-d-aspartate receptors. Experimental Neurology. 163: 239-43. PMID 10785463 DOI: 10.1006/exnr.2000.7374  1
2000 Betarbet R, Porter RH, Greenamyre JT. GluR1 glutamate receptor subunit is regulated differentially in the primate basal ganglia following nigrostriatal dopamine denervation. Journal of Neurochemistry. 74: 1166-74. PMID 10693949  1
1999 Blandini F, Greenamyre JT. Protective and symptomatic strategies for therapy of Parkinson's disease. Drugs of Today (Barcelona, Spain : 1998). 35: 473-83. PMID 12973393  1
1999 Greenamyre JT, MacKenzie G, Peng TI, Stephans SE. Mitochondrial dysfunction in Parkinson's disease. Biochemical Society Symposium. 66: 85-97. PMID 10989660  1
1999 Panov A, Obertone T, Bennett-Desmelik J, Greenamyre JT. Ca(2+)-dependent permeability transition and complex I activity in lymphoblast mitochondria from normal individuals and patients with Huntington's or Alzheimer's disease. Annals of the New York Academy of Sciences. 893: 365-8. PMID 10672268  1
1999 Betarbet R, Greenamyre JT. Differential expression of glutamate receptors by the dopaminergic neurons of the primate striatum. Experimental Neurology. 159: 401-8. PMID 10506511 DOI: 10.1006/exnr.1999.7154  1
1999 Sawa A, Wiegand GW, Cooper J, Margolis RL, Sharp AH, Lawler JF, Greenamyre JT, Snyder SH, Ross CA. Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization. Nature Medicine. 5: 1194-8. PMID 10502825 DOI: 10.1038/13518  1
1999 Martarello L, Greenamyre JT, Goodman MM. Synthesis and evaluation of a new fluorine-18 labeled rotenoid as a potential pet probe of mitochondrial complex I activity Journal of Labelled Compounds and Radiopharmaceuticals. 42: 1039-1051. DOI: 10.1002/(SICI)1099-1344(199911)42:11<1039::AID-JLCR259>3.0.CO;2-1  1
1999 Martarello L, Greenamyre JT, Goodman MM. Synthesis and evaluation of two fluorine-18 labeled reduced rotenoids for marking mitochondrial complex I activity in vivo Journal of Labelled Compounds and Radiopharmaceuticals. 42: S558-S560.  1
1999 Martarello L, Greenamyre JT, Goodman MM. Synthesis and evaluation of a new fluorine-18 labeled rotenoid as potential PET probes of mitochondrial complex I activity Journal of Labelled Compounds and Radiopharmaceuticals. 42: S494-S496.  1
1998 Peng TI, Greenamyre JT. Privileged access to mitochondria of calcium influx through N-methyl-D-aspartate receptors. Molecular Pharmacology. 53: 974-80. PMID 9614198  1
1998 Greene JG, Sheu SS, Gross RA, Greenamyre JT. 3-Nitropropionic acid exacerbates N-methyl-D-aspartate toxicity in striatal culture by multiple mechanisms. Neuroscience. 84: 503-10. PMID 9539220 DOI: 10.1016/S0306-4522(97)00389-8  1
1998 Blandini F, Greenamyre JT. Prospects of glutamate antagonists in the therapy of Parkinson's disease. Fundamental & Clinical Pharmacology. 12: 4-12. PMID 9523179  1
1998 Peng TI, Jou MJ, Sheu SS, Greenamyre JT. Visualization of NMDA receptor-induced mitochondrial calcium accumulation in striatal neurons. Experimental Neurology. 149: 1-12. PMID 9454610 DOI: 10.1006/exnr.1997.6599  1
1998 Blandini F, Nappi G, Greenamyre JT. Quantitative study of mitochondrial complex I in platelets of parkinsonian patients. Movement Disorders : Official Journal of the Movement Disorder Society. 13: 11-5. PMID 9452319 DOI: 10.1002/mds.870130106  0.32
1997 Cory-Slechta DA, Flaugher CL, Evans SB, Pokora MJ, Greenamyre JT. Susceptibility of adult rats to lead-induced changes in NMDA receptor complex function. Neurotoxicology and Teratology. 19: 517-30. PMID 9392787 DOI: 10.1016/S0892-0362(97)00047-0  1
1997 Betarbet R, Turner R, Chockkan V, DeLong MR, Allers KA, Walters J, Levey AI, Greenamyre JT. Dopaminergic neurons intrinsic to the primate striatum. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 6761-8. PMID 9254687  1
1997 Blandini F, Garcia-Osuna M, Greenamyre JT. Subthalamic ablation reverses changes in basal ganglia oxidative metabolism and motor response to apomorphine induced by nigrostriatal lesion in rats. The European Journal of Neuroscience. 9: 1407-13. PMID 9240398 DOI: 10.1111/j.1460-9568.1997.tb01495.x  1
1997 Kilbourn MR, Charalambous A, Frey KA, Sherman P, Higgins DS, Greenamyre JT. Intrastriatal neurotoxin injections reduce in vitro and in vivo binding of radiolabeled rotenoids to mitochondrial complex I. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 17: 265-72. PMID 9119899 DOI: 10.1097/00004647-199703000-00003  1
1997 Cory-Slechta DA, Garcia-Osuna M, Greenamyre JT. Lead-induced changes in NMDA receptor complex binding: correlations with learning accuracy and with sensitivity to learning impairments caused by MK-801 and NMDA administration. Behavioural Brain Research. 85: 161-74. PMID 9105573 DOI: 10.1016/S0166-4328(96)00174-X  1
1996 Blandini F, Greenamyre JT, Nappi G. The role of glutamate in the pathophysiology of Parkinson's disease. Functional Neurology. 11: 3-15. PMID 8936453  1
1996 Greene JG, Greenamyre JT. Bioenergetics and glutamate excitotoxicity. Progress in Neurobiology. 48: 613-34. PMID 8809910 DOI: 10.1016/0301-0082(96)00006-8  1
1996 Blandini F, Porter RH, Greenamyre JT. Glutamate and Parkinson's disease. Molecular Neurobiology. 12: 73-94. PMID 8732541 DOI: 10.1007/BF02740748  1
1996 Kieburtz K, Feigin A, McDermott M, Como P, Abwender D, Zimmerman C, Hickey C, Orme C, Claude K, Sotack J, Greenamyre JT, Dunn C, Shoulson I. A controlled trial of remacemide hydrochloride in Huntington's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 11: 273-7. PMID 8723144 DOI: 10.1002/mds.870110310  1
1996 Higgins DS, Greenamyre JT. [3H]dihydrorotenone binding to NADH: ubiquinone reductase (complex I) of the electron transport chain: an autoradiographic study. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 3807-16. PMID 8656275  1
1996 Greenamyre JT. Pharmacological pallidotomy with glutamate antagonists. Annals of Neurology. 39: 557-8. PMID 8619538 DOI: 10.1002/ana.410390502  1
1996 Greene JG, Greenamyre JT. Manipulation of membrane potential modulates malonate-induced striatal excitotoxicity in vivo. Journal of Neurochemistry. 66: 637-43. PMID 8592134  1
1996 Greene JG, Porter RH, Greenamyre JT. ARL-15896, a novel N-methyl-D-aspartate receptor ion channel antagonist: neuroprotection against mitochondrial metabolic toxicity and regional pharmacology. Experimental Neurology. 137: 66-72. PMID 8566213 DOI: 10.1006/exnr.1996.0007  1
1995 Blandini F, Greenamyre JT. Assay of [3H]dihydrorotenone binding to complex I in intact human platelets. Analytical Biochemistry. 230: 16-9. PMID 8585613 DOI: 10.1006/abio.1995.1430  1
1995 Blandini F, Porter RH, Greenamyre JT. Autoradiographic study of mitochondrial complex I and glutamate receptors in the basal ganglia of rats after unilateral subthalamic lesion. Neuroscience Letters. 186: 99-102. PMID 7777208 DOI: 10.1016/0304-3940(95)11292-5  1
1995 Blandini F, Greenamyre JT. Effect of subthalamic nucleus lesion on mitochondrial enzyme activity in rat basal ganglia. Brain Research. 669: 59-66. PMID 7712165 DOI: 10.1016/0006-8993(94)01233-8  1
1995 Davolio C, Greenamyre JT. Selective vulnerability of the CA1 region of hippocampus to the indirect excitotoxic effects of malonic acid. Neuroscience Letters. 192: 29-32. PMID 7675303 DOI: 10.1016/0304-3940(95)11600-2  1
1995 Messam CA, Greene JG, Greenamyre JT, Robinson MB. Intrastriatal injections of the succinate dehydrogenase inhibitor, malonate, cause a rise in extracellular amino acids that is blocked by MK-801. Brain Research. 684: 221-4. PMID 7583227 DOI: 10.1016/0006-8993(95)00435-S  1
1995 Greene JG, Greenamyre JT. Exacerbation of NMDA, AMPA, and L-glutamate excitotoxicity by the succinate dehydrogenase inhibitor malonate. Journal of Neurochemistry. 64: 2332-8. PMID 7536810  1
1995 Porter RH, Greenamyre JT. Regional variations in the pharmacology of NMDA receptor channel blockers: implications for therapeutic potential. Journal of Neurochemistry. 64: 614-23. PMID 7530291  1
1995 Greene JG, Greenamyre JT. Characterization of the excitotoxic potential of the reversible succinate dehydrogenase inhibitor malonate. Journal of Neurochemistry. 64: 430-6. PMID 7528265  1
1995 Angel R, Greenamyre JT. Chronic treatment with thioctic acid does not protect against malonate toxicity in vivo. Neuroscience Letters. 196: 125-7. PMID 7501239 DOI: 10.1016/0304-3940(95)11863-R  1
1994 Koller WC, Busenbark K, Miner K. The relationship of essential tremor to other movement disorders: report on 678 patients. Essential Tremor Study Group. Annals of Neurology. 35: 717-23. PMID 8210229 DOI: 10.1002/ana.410350613  1
1994 Greenamyre JT, Eller RV, Zhang Z, Ovadia A, Kurlan R, Gash DM. Antiparkinsonian effects of remacemide hydrochloride, a glutamate antagonist, in rodent and primate models of Parkinson's disease. Annals of Neurology. 35: 655-61. PMID 8210221 DOI: 10.1002/ana.410350605  1
1994 Greenamyre JT, Garcia-Osuna M, Greene JG. The endogenous cofactors, thioctic acid and dihydrolipoic acid, are neuroprotective against NMDA and malonic acid lesions of striatum. Neuroscience Letters. 171: 17-20. PMID 8084483 DOI: 10.1016/0304-3940(94)90593-2  1
1994 Porter RH, Greenamyre JT. Inhibition of autoradiographic MK-801 binding by an endogenous factor. Neuroscience Letters. 169: 105-8. PMID 8047262 DOI: 10.1016/0304-3940(94)90367-0  1
1994 Porter RH, Greene JG, Higgins DS, Greenamyre JT. Polysynaptic regulation of glutamate receptors and mitochondrial enzyme activities in the basal ganglia of rats with unilateral dopamine depletion. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 7192-9. PMID 7965108  1
1994 Greenamyre JT. Recent developments in the cause and treatment of movement disorders. Current Opinion in Neurology. 7: 323-4. PMID 7952240  1
1994 Porter RH, Greenamyre JT. Regional variations in the pharmacology of AMPA receptors as revealed by receptor autoradiography. Brain Research. 664: 202-6. PMID 7534602  0.84
1994 Greenamyre JT, Porter RH. Anatomy and physiology of glutamate in the CNS. Neurology. 44: S7-13. PMID 7526272  1
1993 Greenamyre JT, Maragos WF. Neurotransmitter receptors in Alzheimer disease. Cerebrovascular and Brain Metabolism Reviews. 5: 61-94. PMID 8392361  1
1993 Greene JG, Porter RH, Eller RV, Greenamyre JT. Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum. Journal of Neurochemistry. 61: 1151-4. PMID 8360680  1
1993 Greenamyre JT. Glutamate-dopamine interactions in the basal ganglia: relationship to Parkinson's disease. Journal of Neural Transmission. General Section. 91: 255-69. PMID 8099800 DOI: 10.1007/BF01245235  1
1993 Sandhu FA, Porter RH, Eller RV, Zain SB, Salim M, Greenamyre JT. NMDA and AMPA receptors in transgenic mice expressing human beta-amyloid protein. Journal of Neurochemistry. 61: 2286-9. PMID 7504089  1
1992 Greenamyre JT, Higgins DS, Eller RV. Quantitative autoradiography of dihydrorotenone binding to complex I of the electron transport chain. Journal of Neurochemistry. 59: 746-9. PMID 1629744  1
1992 Albin RL, Greenamyre JT. Alternative excitotoxic hypotheses. Neurology. 42: 733-8. PMID 1314341  1
1991 Greenamyre JT. Neuronal bioenergetic defects, excitotoxicity and Alzheimer's disease: "use it and lose it". Neurobiology of Aging. 12: 334-6; discussion 35. PMID 1961363 DOI: 10.1016/0197-4580(91)90012-9  1
1991 Maragos WF, Greenamyre JT, Chu DC, Penney JB, Young AB. A study of cortical and hippocampal NMDA and PCP receptors following selective cortical and subcortical lesions. Brain Research. 538: 36-45. PMID 1850317 DOI: 10.1016/0006-8993(91)90373-4  0.88
1991 Kieburtz KD, Epstein LG, Gelbard HA, Greenamyre JT. Excitotoxicity and dopaminergic dysfunction in the acquired immunodeficiency syndrome dementia complex. Therapeutic implications. Archives of Neurology. 48: 1281-4. PMID 1845034 DOI: 10.1001/archneur.1991.00530240087028  1
1991 Greenamyre JT, O'Brien CF. N-methyl-D-aspartate antagonists in the treatment of Parkinson's disease. Archives of Neurology. 48: 977-81. PMID 1835370 DOI: 10.1001/archneur.1991.00530210109030  1
1991 Klockgether T, Turski L, Honoré T, Zhang ZM, Gash DM, Kurlan R, Greenamyre JT. The AMPA receptor antagonist NBQX has antiparkinsonian effects in monoamine-depleted rats and MPTP-treated monkeys. Annals of Neurology. 30: 717-23. PMID 1662477 DOI: 10.1002/ana.410300513  1
1990 Greenamyre JT, Higgins DS, Young AB, Penney JB. Regional ontogeny of a unique glutamate recognition site in rat brain: an autoradiographic study. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 8: 437-45. PMID 2174635 DOI: 10.1016/0736-5748(90)90076-E  1
1990 Penney JB, Maragos WF, Greenamyre JT, Debowey DL, Hollingsworth Z, Young AB. Excitatory amino acid binding sites in the hippocampal region of Alzheimer's disease and other dementias. Journal of Neurology, Neurosurgery, and Psychiatry. 53: 314-20. PMID 2160518 DOI: 10.1136/jnnp.53.4.314  1
1990 Greenamyre JT, Higgins DS, Young AB. Sodium-dependent D-aspartate 'binding' is not a measure of presynaptic neuronal uptake sites in an autoradiographic assay. Brain Research. 511: 310-8. PMID 2159361 DOI: 10.1016/0006-8993(90)90176-C  0.96
1990 Corner TR, Beaman TC, Greenamyre JT, Gerhardt P. Spectrophotometric determination of refractive index increment for bacterial cells Journal of Microbiological Methods. 11: 255-260. DOI: 10.1016/0167-7012(90)90062-B  1
1989 Cha JH, Hollingsworth ZR, Greenamyre JT, Young AB. Contamination of commercially available quisqualic acid by glutamate-like and aspartate-like substances. Journal of Neuroscience Methods. 27: 143-8. PMID 2565415 DOI: 10.1016/0165-0270(89)90097-6  1
1989 Greenamyre JT, Young AB. Excitatory amino acids and Alzheimer's disease. Neurobiology of Aging. 10: 593-602. PMID 2554168 DOI: 10.1016/0197-4580(89)90143-7  1
1989 Greenamyre JT, Young AB. Synaptic localization of striatal NMDA, quisqualate and kainate receptors. Neuroscience Letters. 101: 133-7. PMID 2549458 DOI: 10.1016/0304-3940(89)90519-3  1
1989 Greenamyre JT, Young AB. Authors' response to commentaries Neurobiology of Aging. 10: 618-620. DOI: 10.1016/0197-4580(89)90153-X  1
1988 Greenamyre JT, Maragos WF, Albin RL, Penney JB, Young AB. Glutamate transmission and toxicity in Alzheimer's disease. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 12: 421-30. PMID 2900537 DOI: 10.1016/0278-5846(88)90102-9  1
1988 Cha JH, Greenamyre JT, Nielsen EO, Penney JB, Young AB. Properties of quisqualate-sensitive L-[3H]glutamate binding sites in rat brain as determined by quantitative autoradiography. Journal of Neurochemistry. 51: 469-78. PMID 2899133  1
1988 Barks JD, Silverstein FS, Sims K, Greenamyre JT, Johnston MV. Glutamate recognition sites in human fetal brain. Neuroscience Letters. 84: 131-6. PMID 2893319 DOI: 10.1016/0304-3940(88)90396-5  1
1988 Young AB, Greenamyre JT, Hollingsworth Z, Albin R, D'Amato C, Shoulson I, Penney JB. NMDA receptor losses in putamen from patients with Huntington's disease. Science (New York, N.Y.). 241: 981-3. PMID 2841762 DOI: 10.1126/science.2841762  1
1987 Olson JM, Greenamyre JT, Penney JB, Young AB. Autoradiographic localization of cerebellar excitatory amino acid binding sites in the mouse. Neuroscience. 22: 913-23. PMID 2891079 DOI: 10.1016/0306-4522(87)92969-1  1
1987 Greenamyre JT, Penney JB, D'Amato CJ, Young AB. Dementia of the Alzheimer's type: changes in hippocampal L-[3H]glutamate binding. Journal of Neurochemistry. 48: 543-51. PMID 2878980 DOI: 10.1111/j.1471-4159.1987.tb04127.x  1
1987 Maragos WF, Greenamyre JT, Penney JB, Young AB. Glutamate dysfunction in Alzheimer's disease: an hypothesis Trends in Neurosciences. 10: 65-68. DOI: 10.1016/0166-2236(87)90025-7  1
1987 Maragos WF, Greenamyre JT, Penney JB, Young AB. Reply from W.F. Maragos and colleagues Trends in Neurosciences. 10: 407. DOI: 10.1016/0166-2236(87)90009-9  1
1986 Maragos WF, Chu DC, Greenamyre JT, Penney JB, Young AB. High correlation between the localization of [3H]TCP binding and NMDA receptors. European Journal of Pharmacology. 123: 173-4. PMID 3011454 DOI: 10.1016/0014-2999(86)90703-X  1
1986 Greenamyre JT. The role of glutamate in neurotransmission and in neurologic disease. Archives of Neurology. 43: 1058-63. PMID 2428340 DOI: 10.1001/archneur.1986.00520100062016  1
1985 Greenamyre JT, Olson JM, Penney JB, Young AB. Autoradiographic characterization of N-methyl-D-aspartate-, quisqualate- and kainate-sensitive glutamate binding sites. The Journal of Pharmacology and Experimental Therapeutics. 233: 254-63. PMID 2984415  1
1985 Greenamyre JT, Penney JB, Young AB, D'Amato CJ, Hicks SP, Shoulson I. Alterations in L-glutamate binding in Alzheimer's and Huntington's diseases. Science (New York, N.Y.). 227: 1496-9. PMID 2858129 DOI: 10.1126/science.2858129  1
1984 Greenamyre JT, Young AB, Penney JB. Quantitative autoradiographic distribution of L-[3H]glutamate-binding sites in rat central nervous system. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 4: 2133-44. PMID 6088729  1
1983 Greenamyre JT, Young AB, Penney JB. Quantitative autoradiography of L-[3H]glutamate binding to rat brain. Neuroscience Letters. 37: 155-60. PMID 6136011 DOI: 10.1016/0304-3940(83)90146-5  1
1982 Beaman TC, Greenamyre JT, Corner TR, Pankratz HS, Gerhardt P. Bacterial spore heat resistance correlated with water content, wet density, and protoplast/sporoplast volume ratio. Journal of Bacteriology. 150: 870-7. PMID 6802802  1
1982 Gerhardt P, Beaman TC, Corner TR, Greenamyre JT, Tisa LS. Photometric immersion refractometry of bacterial spores. Journal of Bacteriology. 150: 643-8. PMID 6802796  1
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