Viviana Gradinaru - Publications

Affiliations: 
Stanford University, Palo Alto, CA 
 Neuroscience California Institute of Technology, Pasadena, CA 
Area:
Control of Brain Function and Behavior

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Year Citation  Score
2024 Ding X, Chen X, Sullivan EE, Shay TF, Gradinaru V. Fast, accurate ranking of engineered proteins by target binding propensity using structure modeling. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 38582966 DOI: 10.1016/j.ymthe.2024.04.003  0.764
2023 Coughlin GM, Borsos M, Appling N, Barcelona BH, Mayfield AMH, Mackey ED, Eser RA, Chen X, Kumar SR, Gradinaru V. Spatial genomics of AAVs reveals mechanism of transcriptional crosstalk that enables targeted delivery of large genetic cargo. Biorxiv : the Preprint Server For Biology. PMID 38187707 DOI: 10.1101/2023.12.23.573214  0.637
2023 Henrickson A, Ding X, Seal AG, Qu Z, Tomlinson L, Forsey J, Gradinaru V, Oka K, Demeler B. Characterization and quantification of adeno-associated virus capsid-loading states by multi-wavelength analytical ultracentrifugation with UltraScan. Nanomedicine (London, England). 18: 1519-1534. PMID 37877696 DOI: 10.2217/nnm-2023-0156  0.728
2023 Chuapoco MR, Flytzanis NC, Goeden N, Christopher Octeau J, Roxas KM, Chan KY, Scherrer J, Winchester J, Blackburn RJ, Campos LJ, Man KNM, Sun J, Chen X, Lefevre A, Singh VP, ... ... Gradinaru V, et al. Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain. Nature Nanotechnology. PMID 37430038 DOI: 10.1038/s41565-023-01419-x  0.768
2023 Campos LJ, Arokiaraj CM, Chuapoco MR, Chen X, Goeden N, Gradinaru V, Fox AS. Advances in AAV technology for delivering genetically encoded cargo to the nonhuman primate nervous system. Current Research in Neurobiology. 4: 100086. PMID 37397806 DOI: 10.1016/j.crneur.2023.100086  0.652
2023 Chen X, Wolfe DA, Bindu DS, Zhang M, Taskin N, Goertsen D, Shay TF, Sullivan EE, Huang SF, Ravindra Kumar S, Arokiaraj CM, Plattner VM, Campos LJ, Mich JK, Monet D, ... ... Gradinaru V, et al. Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates. Nature Communications. 14: 3345. PMID 37291094 DOI: 10.1038/s41467-023-38582-7  0.793
2023 Shay TF, Sullivan EE, Ding X, Chen X, Ravindra Kumar S, Goertsen D, Brown D, Crosby A, Vielmetter J, Borsos M, Wolfe DA, Lam AW, Gradinaru V. Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors. Science Advances. 9: eadg6618. PMID 37075114 DOI: 10.1126/sciadv.adg6618  0.792
2023 Chuapoco M, Flytzanis N, Goeden N, Octeau J, Roxas K, Chan K, Scherrer J, Winchester J, Blackburn R, Campos L, Man KN, Sun J, Chen X, Lefevre A, Singh V, ... ... Gradinaru V, et al. Intravenous functional gene transfer throughout the brain of non-human primates using AAV. Research Square. PMID 36789432 DOI: 10.21203/rs.3.rs-1370972/v1  0.656
2023 Chen X, Wolfe DA, Sivadasan Bindu D, Zhang M, Taskin N, Goertsen D, Shay TF, Sullivan E, Huang SF, Ravindra Kumar S, Arokiaraj CM, Plattner V, Campos LJ, Mich J, Monet D, ... ... Gradinaru V, et al. Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates. Biorxiv : the Preprint Server For Biology. PMID 36711773 DOI: 10.1101/2023.01.12.523844  0.792
2023 Jang MJ, Coughlin GM, Jackson CR, Chen X, Chuapoco MR, Vendemiatti JL, Wang AZ, Gradinaru V. Spatial transcriptomics for profiling the tropism of viral vectors in tissues. Nature Biotechnology. PMID 36702899 DOI: 10.1038/s41587-022-01648-w  0.667
2022 Jang S, Shen HK, Ding X, Miles TF, Gradinaru V. Structural basis of receptor usage by the engineered capsid AAV-PHP.eB. Molecular Therapy. Methods & Clinical Development. 26: 343-354. PMID 36034770 DOI: 10.1016/j.omtm.2022.07.011  0.743
2022 Chen X, Ravindra Kumar S, Adams CD, Yang D, Wang T, Wolfe DA, Arokiaraj CM, Ngo V, Campos LJ, Griffiths JA, Ichiki T, Mazmanian SK, Osborne PB, Keast JR, Miller CT, ... ... Gradinaru V, et al. Engineered AAVs for non-invasive gene delivery to rodent and non-human primate nervous systems. Neuron. PMID 35643078 DOI: 10.1016/j.neuron.2022.05.003  0.635
2022 Challis RC, Ravindra Kumar S, Chen X, Goertsen D, Coughlin GM, Hori AM, Chuapoco MR, Otis TS, Miles TF, Gradinaru V. Adeno-Associated Virus Toolkit to Target Diverse Brain Cells. Annual Review of Neuroscience. PMID 35440143 DOI: 10.1146/annurev-neuro-111020-100834  0.8
2021 Cui L, Guo J, Cranfill SL, Gautam M, Bhattarai J, Olson W, Beattie K, Challis RC, Wu Q, Song X, Raabe T, Gradinaru V, Ma M, Liu Q, Luo W. Glutamate in primary afferents is required for itch transmission. Neuron. PMID 34986325 DOI: 10.1016/j.neuron.2021.12.007  0.758
2021 Goertsen D, Flytzanis NC, Goeden N, Chuapoco MR, Cummins A, Chen Y, Fan Y, Zhang Q, Sharma J, Duan Y, Wang L, Feng G, Chen Y, Ip NY, Pickel J, ... Gradinaru V, et al. AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset. Nature Neuroscience. PMID 34887588 DOI: 10.1038/s41593-021-00969-4  0.321
2021 Kahan A, Greenbaum A, Jang MJ, Robinson JE, Cho JR, Chen X, Kassraian P, Wagenaar DA, Gradinaru V. Light-guided sectioning for precise in situ localization and tissue interface analysis for brain-implanted optical fibers and GRIN lenses. Cell Reports. 36: 109744. PMID 34592157 DOI: 10.1016/j.celrep.2021.109744  0.646
2021 Smith EJ, Farshim PP, Flomen R, Jones ST, McAteer SJ, Deverman BE, Gradinaru V, Bates GP. Use of high-content imaging to quantify transduction of AAV-PHP viruses in the brain following systemic delivery. Brain Communications. 3: fcab105. PMID 34131644 DOI: 10.1093/braincomms/fcab105  0.305
2021 Mich JK, Graybuck LT, Hess EE, Mahoney JT, Kojima Y, Ding Y, Somasundaram S, Miller JA, Kalmbach BE, Radaelli C, Gore BB, Weed N, Omstead V, Bishaw Y, Shapovalova NV, ... ... Gradinaru V, et al. Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex. Cell Reports. 34: 108754. PMID 33789096 DOI: 10.1016/j.celrep.2021.108754  0.663
2021 Graybuck LT, Daigle TL, Sedeño-Cortés AE, Walker M, Kalmbach B, Lenz GH, Morin E, Nguyen TN, Garren E, Bendrick JL, Kim TK, Zhou T, Mortrud M, Yao S, Siverts LA, ... ... Gradinaru V, et al. Enhancer viruses for combinatorial cell-subclass-specific labeling. Neuron. PMID 33789083 DOI: 10.1016/j.neuron.2021.03.011  0.681
2021 Cho JR, Chen X, Kahan A, Robinson JE, Wagenaar DA, Gradinaru V. Dorsal raphe dopamine neurons signal motivational salience dependent on internal state, expectation, and behavioral context. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 33563725 DOI: 10.1523/JNEUROSCI.2690-20.2021  0.646
2020 Badimon A, Strasburger HJ, Ayata P, Chen X, Nair A, Ikegami A, Hwang P, Chan AT, Graves SM, Uweru JO, Ledderose C, Kutlu MG, Wheeler MA, Kahan A, Ishikawa M, ... ... Gradinaru V, et al. Negative feedback control of neuronal activity by microglia. Nature. PMID 32999463 DOI: 10.1038/s41586-020-2777-8  0.772
2020 Gradinaru V. Expanding the brain researcher's toolkit. Science (New York, N.Y.). 369: 637. PMID 32764063 DOI: 10.1126/science.abd2660  0.303
2020 Seo JW, Ingham ES, Mahakian L, Tumbale S, Wu B, Aghevlian S, Shams S, Baikoghli M, Jain P, Ding X, Goeden N, Dobreva T, Flytzanis NC, Chavez M, Singhal K, ... ... Gradinaru V, et al. Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation. Nature Communications. 11: 2102. PMID 32355221 DOI: 10.1038/S41467-020-15818-4  0.775
2020 Ravindra Kumar S, Miles TF, Chen X, Brown D, Dobreva T, Huang Q, Ding X, Luo Y, Einarsson PH, Greenbaum A, Jang MJ, Deverman BE, Gradinaru V. Multiplexed Cre-dependent selection yields systemic AAVs for targeting distinct brain cell types. Nature Methods. PMID 32313222 DOI: 10.1038/S41592-020-0799-7  0.797
2020 Rauch JN, Luna G, Guzman E, Audouard M, Challis C, Sibih YE, Leshuk C, Hernandez I, Wegmann S, Hyman BT, Gradinaru V, Kampmann M, Kosik KS. LRP1 is a master regulator of tau uptake and spread. Nature. 580: 381-385. PMID 32296178 DOI: 10.1038/S41586-020-2156-5  0.558
2020 Yao S, Yuan P, Ouellette B, Zhou T, Mortrud M, Balaram P, Chatterjee S, Wang Y, Daigle TL, Tasic B, Kuang X, Gong H, Luo Q, Zeng S, Curtright A, ... ... Gradinaru V, et al. RecV recombinase system for in vivo targeted optogenomic modifications of single cells or cell populations. Nature Methods. PMID 32203389 DOI: 10.1038/S41592-020-0774-3  0.401
2020 Challis C, Hori A, Sampson TR, Yoo BB, Challis RC, Hamilton AM, Mazmanian SK, Volpicelli-Daley LA, Gradinaru V. Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice. Nature Neuroscience. PMID 32066981 DOI: 10.1038/S41593-020-0589-7  0.746
2020 Sampson TR, Challis C, Jain N, Moiseyenko A, Ladinsky MS, Shastri GG, Thron T, Needham BD, Horvath I, Debelius JW, Janssen S, Knight R, Wittung-Stafshede P, Gradinaru V, Chapman M, et al. A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice. Elife. 9. PMID 32043464 DOI: 10.7554/Elife.53111  0.558
2020 Ueda HR, Ertürk A, Chung K, Gradinaru V, Chédotal A, Tomancak P, Keller PJ. Tissue clearing and its applications in neuroscience. Nature Reviews. Neuroscience. PMID 31896771 DOI: 10.1038/S41583-019-0250-1  0.318
2020 Sampson TR, Challis C, Jain N, Moiseyenko A, Ladinsky MS, Shastri GG, Thron T, Needham BD, Horvath I, Debelius JW, Janssen S, Knight R, Wittung-Stafshede P, Gradinaru V, Chapman M, et al. Author response: A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice Elife. DOI: 10.7554/Elife.53111.Sa2  0.51
2019 Patriarchi T, Cho JR, Merten K, Marley A, Broussard GJ, Liang R, Williams J, Nimmerjahn A, von Zastrow M, Gradinaru V, Tian L. Imaging neuromodulators with high spatiotemporal resolution using genetically encoded indicators. Nature Protocols. PMID 31732722 DOI: 10.1038/S41596-019-0239-2  0.371
2019 Bedbrook CN, Yang KK, Robinson JE, Mackey ED, Gradinaru V, Arnold FH. Machine learning-guided channelrhodopsin engineering enables minimally invasive optogenetics. Nature Methods. PMID 31611694 DOI: 10.1038/S41592-019-0583-8  0.432
2019 Song A, Dai W, Jang MJ, Medrano L, Li Z, Zhao H, Shao M, Tan J, Li A, Ning T, Miller MM, Armstrong B, Huss JM, Zhu Y, Liu Y, ... Gradinaru V, et al. Low- and high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue. The Journal of Clinical Investigation. PMID 31573981 DOI: 10.1172/Jci129167  0.726
2019 Ramirez-Zamora A, Giordano J, Boyden ES, Gradinaru V, Gunduz A, Starr PA, Sheth SA, McIntyre CC, Fox MD, Vitek J, Vedam-Mai V, Akbar U, Almeida L, Bronte-Stewart HM, Mayberg HS, et al. Proceedings of the Sixth Deep Brain Stimulation Think Tank Modulation of Brain Networks and Application of Advanced Neuroimaging, Neurophysiology, and Optogenetics. Frontiers in Neuroscience. 13: 936. PMID 31572109 DOI: 10.3389/Fnins.2019.00936  0.361
2019 Robinson JE, Coughlin GM, Hori AM, Cho JR, Mackey ED, Turan Z, Patriarchi T, Tian L, Gradinaru V. Optical dopamine monitoring with dLight1 reveals mesolimbic phenotypes in a mouse model of neurofibromatosis type 1. Elife. 8. PMID 31545171 DOI: 10.7554/Elife.48983  0.422
2019 Challis RC, Kumar SR, Chan KY, Challis C, Beadle K, Jang MJ, Kim HM, Rajendran PS, Tompkins JD, Shivkumar K, Deverman BE, Gradinaru V. Publisher Correction: Systemic AAV vectors for widespread and targeted gene delivery in rodents. Nature Protocols. PMID 31312046 DOI: 10.1038/S41596-019-0155-5  0.732
2019 Rajendran PS, Challis RC, Fowlkes CC, Hanna P, Tompkins JD, Jordan MC, Hiyari S, Gabris-Weber BA, Greenbaum A, Chan KY, Deverman BE, Münzberg H, Ardell JL, Salama G, Gradinaru V, et al. Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies. Nature Communications. 10: 1944. PMID 31028266 DOI: 10.1038/S41467-019-09770-1  0.678
2019 Zeng J, Wang Y, Luo Z, Chang LC, Yoo JS, Yan H, Choi Y, Xie X, Deverman BE, Gradinaru V, Gupton SL, Zlokovic BV, Zhao Z, Jung JU. TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice. Cell Reports. 27: 549-560.e6. PMID 30970257 DOI: 10.1016/J.Celrep.2018.12.055  0.327
2019 Challis RC, Ravindra Kumar S, Chan KY, Challis C, Beadle K, Jang MJ, Kim HM, Rajendran PS, Tompkins JD, Shivkumar K, Deverman BE, Gradinaru V. Systemic AAV vectors for widespread and targeted gene delivery in rodents. Nature Protocols. PMID 30626963 DOI: 10.1038/S41596-018-0097-3  0.765
2019 Robinson JE, Coughlin GM, Hori AM, Cho JR, Mackey ED, Turan Z, Patriarchi T, Tian L, Gradinaru V. Author response: Optical dopamine monitoring with dLight1 reveals mesolimbic phenotypes in a mouse model of neurofibromatosis type 1 Elife. DOI: 10.7554/Elife.48983.036  0.355
2018 Mano T, Albanese A, Dodt HU, Erturk A, Gradinaru V, Treweek JB, Miyawaki A, Chung K, Ueda HR. Whole-Brain Analysis of Cells and Circuits by Tissue Clearing and Light-Sheet Microscopy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 38: 9330-9337. PMID 30381424 DOI: 10.1523/Jneurosci.1677-18.2018  0.38
2018 Patriarchi T, Cho JR, Merten K, Howe MW, Marley A, Xiong WH, Folk RW, Broussard GJ, Liang R, Jang MJ, Zhong H, Dombeck D, von Zastrow M, Nimmerjahn A, Gradinaru V, et al. Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors. Science (New York, N.Y.). PMID 29853555 DOI: 10.1126/Science.Aat4422  0.745
2018 Gradinaru V, Treweek J, Overton K, Deisseroth K. Hydrogel-Tissue Chemistry: Principles and Applications. Annual Review of Biophysics. 47: 355-376. PMID 29792820 DOI: 10.1146/annurev-biophys-070317-032905  0.55
2018 Zelikowsky M, Hui M, Karigo T, Choe A, Yang B, Blanco MR, Beadle K, Gradinaru V, Deverman BE, Anderson DJ. The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress. Cell. 173: 1265-1279.e19. PMID 29775595 DOI: 10.1016/J.Cell.2018.03.037  0.463
2018 Bedbrook CN, Deverman BE, Gradinaru V. Viral Strategies for Targeting the Central and Peripheral Nervous Systems. Annual Review of Neuroscience. PMID 29709207 DOI: 10.1146/Annurev-Neuro-080317-062048  0.403
2017 Ruan H, Brake J, Robinson JE, Liu Y, Jang M, Xiao C, Zhou C, Gradinaru V, Yang C. Deep tissue optical focusing and optogenetic modulation with time-reversed ultrasonically encoded light. Science Advances. 3: eaao5520. PMID 29226248 DOI: 10.1126/Sciadv.Aao5520  0.449
2017 Greenbaum A, Jang MJ, Challis C, Gradinaru V. Q&A: How can advances in tissue clearing and optogenetics contribute to our understanding of normal and diseased biology? Bmc Biology. 15: 87. PMID 28946882 DOI: 10.1186/S12915-017-0421-3  0.575
2017 Robinson JE, Gradinaru V. Dopaminergic dysfunction in neurodevelopmental disorders: recent advances and synergistic technologies to aid basic research. Current Opinion in Neurobiology. 48: 17-29. PMID 28850815 DOI: 10.1016/J.Conb.2017.08.003  0.418
2017 Chan KY, Jang MJ, Yoo BB, Greenbaum A, Ravi N, Wu WL, Sánchez-Guardado L, Lois C, Mazmanian SK, Deverman BE, Gradinaru V. Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems. Nature Neuroscience. PMID 28671695 DOI: 10.1038/Nn.4593  0.391
2017 Cho JR, Treweek JB, Robinson JE, Xiao C, Bremner LR, Greenbaum A, Gradinaru V. Dorsal Raphe Dopamine Neurons Modulate Arousal and Promote Wakefulness by Salient Stimuli. Neuron. PMID 28602690 DOI: 10.1016/J.Neuron.2017.05.020  0.75
2017 Allen WE, Kauvar IV, Chen MZ, Richman EB, Yang SJ, Chan K, Gradinaru V, Deverman BE, Luo L, Deisseroth K. Global Representations of Goal-Directed Behavior in Distinct Cell Types of Mouse Neocortex. Neuron. 94: 891-907.e6. PMID 28521139 DOI: 10.1016/J.Neuron.2017.04.017  0.758
2017 Bedbrook CN, Rice AJ, Yang KK, Ding X, Chen S, LeProust EM, Gradinaru V, Arnold FH. Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsins. Proceedings of the National Academy of Sciences of the United States of America. PMID 28283661 DOI: 10.1073/Pnas.1700269114  0.747
2017 Ruan H, Brake J, Robinson JE, Jang M, Xiao C, Zhou C, Gradinaru V, Yang C. Optogenetic Control of Neural Activity with Time-Reversed Ultrasound Encoded Light Brain. DOI: 10.1364/Brain.2017.Brm3B.3  0.44
2017 Gradinaru V. On Brain Circuits and Tools: Switches for Locomotion, Reward, and a Viral-based Approach to Non-invasive Whole-brain Cargo Delivery Brain. DOI: 10.1364/Brain.2017.Brm2B.2  0.368
2017 Gradinaru V. Switches for multiple behavioral states and a viral-based approach to non-invasive whole-brain cargo delivery (Conference Presentation) Proceedings of Spie. 10194. DOI: 10.1117/12.2264147  0.452
2016 Sampson TR, Debelius JW, Thron T, Janssen S, Shastri GG, Ilhan ZE, Challis C, Schretter CE, Rocha S, Gradinaru V, Chesselet MF, Keshavarzian A, Shannon KM, Krajmalnik-Brown R, Wittung-Stafshede P, et al. Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease. Cell. 167: 1469-1480.e12. PMID 27912057 DOI: 10.1016/J.Cell.2016.11.018  0.547
2016 Treweek JB, Gradinaru V. Extracting structural and functional features of widely distributed biological circuits with single cell resolution via tissue clearing and delivery vectors. Current Opinion in Biotechnology. 40: 193-207. PMID 27393829 DOI: 10.1016/j.copbio.2016.03.012  0.323
2016 Shah S, Lubeck E, Schwarzkopf M, He TF, Greenbaum A, Sohn CH, Lignell A, Choi HM, Gradinaru V, Pierce NA, Cai L. Single-molecule RNA detection at depth via hybridization chain reaction and tissue hydrogel embedding and clearing. Development (Cambridge, England). PMID 27342713 DOI: 10.1242/Dev.138560  0.311
2016 Xiao C, Cho JR, Zhou C, Treweek JB, Chan K, McKinney SL, Yang B, Gradinaru V. Cholinergic Mesopontine Signals Govern Locomotion and Reward through Dissociable Midbrain Pathways. Neuron. 90: 333-347. PMID 27100197 DOI: 10.1016/j.neuron.2016.03.028  0.318
2016 Deverman BE, Pravdo PL, Simpson BP, Kumar SR, Chan KY, Banerjee A, Wu WL, Yang B, Huber N, Pasca SP, Gradinaru V. Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain. Nature Biotechnology. PMID 26829320 DOI: 10.1038/Nbt.3440  0.388
2016 Deverman BE, Pravdo PL, Simpson BP, Kumar SR, Luo Y, Chan KY, Banerjee A, Wu W, Yang B, Huber N, Pasca SP, Gradinaru V. 252. Using Cre-Dependent In Vivo Selection to Identify AAV Variants That Enable Efficient and Widespread Gene Transfer to the Adult Central Nervous System Molecular Therapy. 24: S99. DOI: 10.1016/S1525-0016(16)33061-1  0.395
2016 Rice AJ, Bedbrook CN, Yang KK, Gradinaru V, Arnold FH. Rhodopsin Engineering through Structure-Guided Recombination Biophysical Journal. 110: 170a. DOI: 10.1016/J.Bpj.2015.11.947  0.336
2016 Gradinaru V. Tools for Anatomical and Functional Analysis of Widely Distributed Brain Networks Biophysical Journal. 110: 364a-365a. DOI: 10.1016/J.BPJ.2015.11.1965  0.395
2014 Yang B, Treweek JB, Kulkarni RP, Deverman BE, Chen CK, Lubeck E, Shah S, Cai L, Gradinaru V. Single-cell phenotyping within transparent intact tissue through whole-body clearing. Cell. 158: 945-58. PMID 25088144 DOI: 10.1016/J.Cell.2014.07.017  0.305
2014 Birmingham K, Gradinaru V, Anikeeva P, Grill WM, Pikov V, McLaughlin B, Pasricha P, Weber D, Ludwig K, Famm K. Bioelectronic medicines: a research roadmap. Nature Reviews. Drug Discovery. 13: 399-400. PMID 24875080 DOI: 10.1038/Nrd4351  0.571
2014 Deisseroth K, Gradinaru V. Advances in Neurotechniques: Methods that Reveal the Structure and Function of the Brain Science. 345: 698.3-698. DOI: 10.1126/science.345.6197.698-c  0.543
2013 Sukhotinsky I, Chan AM, Ahmed OJ, Rao VR, Gradinaru V, Ramakrishnan C, Deisseroth K, Majewska AK, Cash SS. Optogenetic delay of status epilepticus onset in an in vivo rodent epilepsy model. Plos One. 8: e62013. PMID 23637949 DOI: 10.1371/Journal.Pone.0062013  0.482
2013 Chung K, Wallace J, Kim SY, Kalyanasundaram S, Andalman AS, Davidson TJ, Mirzabekov JJ, Zalocusky KA, Mattis J, Denisin AK, Pak S, Bernstein H, Ramakrishnan C, Grosenick L, Gradinaru V, et al. Structural and molecular interrogation of intact biological systems. Nature. 497: 332-7. PMID 23575631 DOI: 10.1038/Nature12107  0.74
2012 Mattis J, Tye KM, Ferenczi EA, Ramakrishnan C, O'Shea DJ, Prakash R, Gunaydin LA, Hyun M, Fenno LE, Gradinaru V, Yizhar O, Deisseroth K. Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins. Nature Methods. 9: 159-72. PMID 22179551 DOI: 10.1038/Nmeth.1808  0.74
2011 Domingos AI, Vaynshteyn J, Voss HU, Ren X, Gradinaru V, Zang F, Deisseroth K, de Araujo IE, Friedman J. Leptin regulates the reward value of nutrient. Nature Neuroscience. 14: 1562-8. PMID 22081158 DOI: 10.1038/nn.2977  0.491
2011 Goshen I, Brodsky M, Prakash R, Wallace J, Gradinaru V, Ramakrishnan C, Deisseroth K. Dynamics of retrieval strategies for remote memories. Cell. 147: 678-89. PMID 22019004 DOI: 10.1016/J.Cell.2011.09.033  0.444
2011 Tye KM, Prakash R, Kim SY, Fenno LE, Grosenick L, Zarabi H, Thompson KR, Gradinaru V, Ramakrishnan C, Deisseroth K. Amygdala circuitry mediating reversible and bidirectional control of anxiety. Nature. 471: 358-62. PMID 21389985 DOI: 10.1038/Nature09820  0.767
2010 Witten IB, Lin SC, Brodsky M, Prakash R, Diester I, Anikeeva P, Gradinaru V, Ramakrishnan C, Deisseroth K. Cholinergic interneurons control local circuit activity and cocaine conditioning. Science (New York, N.Y.). 330: 1677-81. PMID 21164015 DOI: 10.1126/Science.1193771  0.772
2010 Lee JH, Durand R, Gradinaru V, Zhang F, Goshen I, Kim DS, Fenno LE, Ramakrishnan C, Deisseroth K. Global and local fMRI signals driven by neurons defined optogenetically by type and wiring. Nature. 465: 788-92. PMID 20473285 DOI: 10.1038/Nature09108  0.747
2010 Gradinaru V, Zhang F, Ramakrishnan C, Mattis J, Prakash R, Diester I, Goshen I, Thompson KR, Deisseroth K. Molecular and cellular approaches for diversifying and extending optogenetics. Cell. 141: 154-65. PMID 20303157 DOI: 10.1016/J.Cell.2010.02.037  0.778
2010 Zhang F, Gradinaru V, Adamantidis AR, Durand R, Airan RD, de Lecea L, Deisseroth K. Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures. Nature Protocols. 5: 439-56. PMID 20203662 DOI: 10.1038/Nprot.2009.226  0.761
2010 Lee JH, Durand R, Gradinaru V, Zhang F, Goshen I, Kim DS, Fenno LE, Ramakrishnan C, Deisseroth K. Lee et al. reply Nature. 468: E4-E5. DOI: 10.1038/Nature09533  0.733
2009 Gradinaru V, Mogri M, Thompson KR, Henderson JM, Deisseroth K. Optical deconstruction of parkinsonian neural circuitry. Science (New York, N.Y.). 324: 354-9. PMID 19299587 DOI: 10.1126/Science.1167093  0.791
2008 Gradinaru V, Thompson KR, Deisseroth K. eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications. Brain Cell Biology. 36: 129-39. PMID 18677566 DOI: 10.1007/s11068-008-9027-6  0.522
2008 Schneider MB, Gradinaru V, Zhang F, Deisseroth K. Controlling neuronal activity. The American Journal of Psychiatry. 165: 562. PMID 18450936 DOI: 10.1176/Appi.Ajp.2008.08030444  0.576
2007 Gradinaru V, Thompson KR, Zhang F, Mogri M, Kay K, Schneider MB, Deisseroth K. Targeting and readout strategies for fast optical neural control in vitro and in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 14231-8. PMID 18160630 DOI: 10.1523/Jneurosci.3578-07.2007  0.761
Low-probability matches (unlikely to be authored by this person)
2015 Bedbrook CN, Kato M, Ravindra Kumar S, Lakshmanan A, Nath RD, Sun F, Sternberg PW, Arnold FH, Gradinaru V. Genetically Encoded Spy Peptide Fusion System to Detect Plasma Membrane-Localized Proteins In Vivo. Chemistry & Biology. 22: 1108-21. PMID 26211362 DOI: 10.1016/J.Chembiol.2015.06.020  0.285
2017 Herwig L, Rice AJ, Bedbrook CN, Zhang RK, Lignell A, Cahn JK, Renata H, Dodani SC, Cho I, Cai L, Gradinaru V, Arnold FH. Directed Evolution of a Bright Near-Infrared Fluorescent Rhodopsin Using a Synthetic Chromophore. Cell Chemical Biology. PMID 28262559 DOI: 10.1016/J.Chembiol.2017.02.008  0.285
2017 Bedbrook CN, Yang KK, Rice AJ, Gradinaru V, Arnold FH. Machine learning to design integral membrane channelrhodopsins for efficient eukaryotic expression and plasma membrane localization. Plos Computational Biology. 13: e1005786. PMID 29059183 DOI: 10.1371/Journal.Pcbi.1005786  0.285
2014 Flytzanis NC, Bedbrook CN, Chiu H, Engqvist MK, Xiao C, Chan KY, Sternberg PW, Arnold FH, Gradinaru V. Archaerhodopsin variants with enhanced voltage-sensitive fluorescence in mammalian and Caenorhabditis elegans neurons. Nature Communications. 5: 4894. PMID 25222271 DOI: 10.1038/Ncomms5894  0.285
2014 Flytzanis N, Bedbrook C, Gradinaru V. Neuronal activity sensing and modulation with Archers Spie Newsroom. DOI: 10.1117/2.1201411.005708  0.283
2016 DePas WH, Starwalt-Lee R, Van Sambeek L, Ravindra Kumar S, Gradinaru V, Newman DK. Exposing the Three-Dimensional Biogeography and Metabolic States of Pathogens in Cystic Fibrosis Sputum via Hydrogel Embedding, Clearing, and rRNA Labeling. Mbio. 7. PMID 27677788 DOI: 10.1128/Mbio.00796-16  0.282
2018 Arbabi E, Li J, Hutchins RJ, Kamali SM, Arbabi A, Horie Y, Van Dorpe P, Gradinaru V, Wagenaar DA, Faraon A. Two-photon microscopy with a double-wavelength metasurface objective lens. Nano Letters. PMID 30016110 DOI: 10.1021/Acs.Nanolett.8B01737  0.278
2014 McIsaac RS, Engqvist MK, Wannier T, Rosenthal AZ, Herwig L, Flytzanis NC, Imasheva ES, Lanyi JK, Balashov SP, Gradinaru V, Arnold FH. Directed evolution of a far-red fluorescent rhodopsin. Proceedings of the National Academy of Sciences of the United States of America. 111: 13034-9. PMID 25157169 DOI: 10.1073/Pnas.1413987111  0.271
2023 Bustos FJ, Pandian S, Haensgen H, Zhao JP, Strouf H, Heidenreich M, Swiech L, Deverman BE, Gradinaru V, Zhang F, Constantine-Paton M. Removal of a partial genomic duplication restores synaptic transmission and behavior in the MyosinVA mutant mouse Flailer. Bmc Biology. 21: 232. PMID 37957716 DOI: 10.1186/s12915-023-01714-y  0.271
2023 Bustos FJ, Pandian S, Haensgen H, Zhao JP, Strouf H, Heidenreich M, Swiech L, Deverman B, Gradinaru V, Zhang F, Constantine-Paton M. Removal of a genomic duplication by double-nicking CRISPR restores synaptic transmission and behavior in the MyosinVA mutant mouse Flailer. Biorxiv : the Preprint Server For Biology. PMID 37163068 DOI: 10.1101/2023.04.28.538685  0.269
2016 Gradinaru V, Flytzanis NC. Neuroscience: Fluorescent boost for voltage sensors. Nature. 529: 469-70. PMID 26819038 DOI: 10.1038/529469a  0.263
2021 Brown D, Altermatt M, Dobreva T, Chen S, Wang A, Thomson M, Gradinaru V. Deep Parallel Characterization of AAV Tropism and AAV-Mediated Transcriptional Changes Single-Cell RNA Sequencing. Frontiers in Immunology. 12: 730825. PMID 34759919 DOI: 10.3389/fimmu.2021.730825  0.263
2015 Skennerton CT, Ward LM, Michel A, Metcalfe K, Valiente C, Mullin S, Chan KY, Gradinaru V, Orphan VJ. Genomic Reconstruction of an Uncultured Hydrothermal Vent Gammaproteobacterial Methanotroph (Family Methylothermaceae) Indicates Multiple Adaptations to Oxygen Limitation. Frontiers in Microbiology. 6: 1425. PMID 26779119 DOI: 10.3389/Fmicb.2015.01425  0.253
2022 Seo JW, Ajenjo J, Wu B, Robinson E, Raie MN, Wang J, Tumbale SK, Buccino P, Anders DA, Shen B, Habte FG, Beinat C, James ML, Reyes ST, Ravindra Kumar S, ... ... Gradinaru V, et al. Multimodal imaging of capsid and cargo reveals differential brain targeting and liver detargeting of systemically-administered AAVs. Biomaterials. 121701. PMID 35985893 DOI: 10.1016/j.biomaterials.2022.121701  0.253
2017 Greenbaum A, Chan KY, Dobreva T, Brown D, Balani DH, Boyce R, Kronenberg HM, McBride HJ, Gradinaru V. Bone CLARITY: Clearing, imaging, and computational analysis of osteoprogenitors within intact bone marrow. Science Translational Medicine. 9. PMID 28446689 DOI: 10.1126/scitranslmed.aah6518  0.249
2017 Nath RD, Bedbrook CN, Abrams MJ, Basinger T, Bois JS, Prober DA, Sternberg PW, Gradinaru V, Goentoro L. The Jellyfish Cassiopea Exhibits a Sleep-like State. Current Biology : Cb. PMID 28943083 DOI: 10.1016/J.Cub.2017.08.014  0.249
2016 Pan M, Reid MA, Lowman XH, Kulkarni RP, Tran TQ, Liu X, Yang Y, Hernandez-Davies JE, Rosales KK, Li H, Hugo W, Song C, Xu X, Schones DE, Ann DK, ... Gradinaru V, et al. Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation. Nature Cell Biology. PMID 27617932 DOI: 10.1038/Ncb3410  0.248
2020 Ueda HR, Ertürk A, Chung K, Gradinaru V, Chédotal A, Tomancak P, Keller PJ. Publisher Correction: Tissue clearing and its applications in neuroscience. Nature Reviews. Neuroscience. PMID 32152524 DOI: 10.1038/S41583-020-0291-5  0.24
2018 Davidson C, Gibson A, Gu T, Chandler R, Deverman B, Gradinaru V, Venditti C, Pavan W. Gene therapy for the treatment of Niemann-Pick disease type C1: Comparison of AAV9 to a novel serotype, AAV-PHP.B Molecular Genetics and Metabolism. 123: S36-S37. DOI: 10.1016/J.Ymgme.2017.12.075  0.24
2019 Oikonomou G, Altermatt M, Zhang RW, Coughlin GM, Montz C, Gradinaru V, Prober DA. The Serotonergic Raphe Promote Sleep in Zebrafish and Mice. Neuron. PMID 31248729 DOI: 10.1016/J.Neuron.2019.05.038  0.216
2024 Griffiths JA, Yoo BB, Thuy-Boun P, Cantu VJ, Weldon KC, Challis C, Sweredoski MJ, Chan KY, Thron TM, Sharon G, Moradian A, Humphrey G, Zhu Q, Shaffer JP, Wolan DW, ... ... Gradinaru V, et al. Peripheral neuronal activation shapes the microbiome and alters gut physiology. Cell Reports. 43: 113953. PMID 38517896 DOI: 10.1016/j.celrep.2024.113953  0.209
2022 Endo F, Kasai A, Soto JS, Yu X, Qu Z, Hashimoto H, Gradinaru V, Kawaguchi R, Khakh BS. Molecular basis of astrocyte diversity and morphology across the CNS in health and disease. Science (New York, N.Y.). 378: eadc9020. PMID 36378959 DOI: 10.1126/science.adc9020  0.201
2023 Schubert R, Bae T, Simic B, Smith SN, Park SH, Nagy-Davidescu G, Gradinaru V, Plückthun A, Hur JK. CRISPR-clear imaging of melanin-rich B16-derived solid tumors. Communications Biology. 6: 370. PMID 37016073 DOI: 10.1038/s42003-023-04614-7  0.201
2021 Duan Y, Ye T, Qu Z, Chen Y, Miranda A, Zhou X, Lok KC, Chen Y, Fu AKY, Gradinaru V, Ip NY. Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer's disease alleviates amyloid-related pathologies in mice. Nature Biomedical Engineering. PMID 34312508 DOI: 10.1038/s41551-021-00759-0  0.196
2021 Davidson CD, Gibson AL, Gu T, Baxter LL, Deverman BE, Beadle K, Incao AA, Rodriguez-Gil JL, Fujiwara H, Jiang X, Chandler RJ, Ory DS, Gradinaru V, Venditti CP, Pavan WJ. Improved systemic AAV gene therapy with a neurotrophic capsid in Niemann-Pick disease type C1 mice. Life Science Alliance. 4. PMID 34407999 DOI: 10.26508/lsa.202101040  0.195
2022 Goertsen D, Goeden N, Flytzanis NC, Gradinaru V. Targeting the lung epithelium after intravenous delivery by directed evolution of underexplored sites on the AAV capsid. Molecular Therapy. Methods & Clinical Development. 26: 331-342. PMID 35990749 DOI: 10.1016/j.omtm.2022.07.010  0.182
2021 Wu WL, Adame MD, Liou CW, Barlow JT, Lai TT, Sharon G, Schretter CE, Needham BD, Wang MI, Tang W, Ousey J, Lin YY, Yao TH, Abdel-Haq R, Beadle K, ... Gradinaru V, et al. Microbiota regulate social behaviour via stress response neurons in the brain. Nature. PMID 34194038 DOI: 10.1038/s41586-021-03669-y  0.182
2024 Flynn MJ, Mayfield AMH, Du R, Gradinaru V, Elowitz MB. Synthetic dosage-compensating miRNA circuits allow precision gene therapy for Rett syndrome. Biorxiv : the Preprint Server For Biology. PMID 38559034 DOI: 10.1101/2024.03.13.584179  0.174
2021 Helseth AR, Hernandez-Martinez R, Hall VL, Oliver ML, Turner BD, Caffall ZF, Rittiner JE, Shipman MK, King CS, Gradinaru V, Gerfen C, Costa-Mattioli M, Calakos N. Cholinergic neurons constitutively engage the ISR for dopamine modulation and skill learning in mice. Science (New York, N.Y.). 372. PMID 33888613 DOI: 10.1126/science.abe1931  0.173
2023 Kahan A, Mahe K, Dutta S, Kassraian P, Wang A, Gradinaru V. Immediate responses to ambient light reveal distinct subpopulations of suprachiasmatic VIP neurons. Iscience. 26: 107865. PMID 37766975 DOI: 10.1016/j.isci.2023.107865  0.173
2015 Treweek JB, Chan KY, Flytzanis NC, Yang B, Deverman BE, Greenbaum A, Lignell A, Xiao C, Cai L, Ladinsky MS, Bjorkman PJ, Fowlkes CC, Gradinaru V. Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high-resolution intact circuit mapping and phenotyping. Nature Protocols. 10: 1860-96. PMID 26492141 DOI: 10.1038/nprot.2015.122  0.173
2021 Nagai J, Bellafard A, Qu Z, Yu X, Ollivier M, Gangwani MR, Diaz-Castro B, Coppola G, Schumacher SM, Golshani P, Gradinaru V, Khakh BS. Specific and behaviorally consequential astrocyte G GPCR signaling attenuation in vivo with iβARK. Neuron. PMID 34139149 DOI: 10.1016/j.neuron.2021.05.023  0.172
2022 Abdel-Haq R, Schlachetzki JCM, Boktor JC, Cantu-Jungles TM, Thron T, Zhang M, Bostick JW, Khazaei T, Chilakala S, Morais LH, Humphrey G, Keshavarzian A, Katz JE, Thomson M, Knight R, ... Gradinaru V, et al. A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice. Elife. 11. PMID 36346385 DOI: 10.7554/eLife.81453  0.148
2021 Smith SN, Schubert R, Simic B, Brücher D, Schmid M, Kirk N, Freitag PC, Gradinaru V, Plückthun A. The SHREAD gene therapy platform for paracrine delivery improves tumor localization and intratumoral effects of a clinical antibody. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34001602 DOI: 10.1073/pnas.2017925118  0.144
2014 Pienaar IS, Dexter DT, Gradinaru V. Neurophysiological and Optogenetic Assessment of Brain Networks Involved in Motor Control Movement Disorders: Genetics and Models: Second Edition. 187-199. DOI: 10.1016/B978-0-12-405195-9.00011-1  0.143
2020 Unger EK, Keller JP, Altermatt M, Liang R, Matsui A, Dong C, Hon OJ, Yao Z, Sun J, Banala S, Flanigan ME, Jaffe DA, Hartanto S, Carlen J, Mizuno GO, ... ... Gradinaru V, et al. Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning. Cell. PMID 33333022 DOI: 10.1016/j.cell.2020.11.040  0.138
2021 Fan JP, Geng HZ, Ji YW, Jia T, Treweek JB, Li AA, Zhou CY, Gradinaru V, Xiao C. Age-dependent alterations in key components of the nigrostriatal dopaminergic system and distinct motor phenotypes. Acta Pharmacologica Sinica. PMID 34244603 DOI: 10.1038/s41401-021-00713-5  0.118
2021 Zhu M, Shahbazi M, Martin A, Zhang C, Sozen B, Borsos M, Mandelbaum RS, Paulson RJ, Mole MA, Esbert M, Titus S, Scott RT, Campbell A, Fishel S, Gradinaru V, et al. Human embryo polarization requires PLC signaling to mediate trophectoderm specification. Elife. 10. PMID 34569938 DOI: 10.7554/eLife.65068  0.111
2015 Bedbrook CN, Kato M, Ravindra kumar S, Lakshmanan A, Nath RD, Sun F, Sternberg PW, Arnold FH, Gradinaru V. Genetically Encoded Spy Peptide Fusion System to Detect Plasma Membrane-Localized Proteins In Vivo Chemistry and Biology. 22: 1108-1121. DOI: 10.1016/j.chembiol.2015.06.020  0.082
2015 Ursu D, Gradinaru V, Fahimi B, Boldea I. Six-Phase BLDC Reluctance Machines: FEM-Based Characterization and Four-Quadrant Control Ieee Transactions On Industry Applications. 51: 2105-2115. DOI: 10.1109/Tia.2014.2367110  0.081
2023 Abdel-Haq R, Schlachetzki JCM, Boktor JC, Cantu-Jungles TM, Thron T, Zhang M, Bostick JW, Khazaei T, Chilakala S, Morais LH, Humphrey G, Keshavarzian A, Katz JE, Thomson M, Knight R, ... Gradinaru V, et al. Correction: A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice. Elife. 12. PMID 37650862 DOI: 10.7554/eLife.92367  0.079
2010 Gradinaru V, Hagedorn GA, Joye A. Exponentially accurate semiclassical tunneling wavefunctions in one dimension Journal of Physics a: Mathematical and Theoretical. 43. DOI: 10.1088/1751-8113/43/47/474026  0.075
1998 Andronescu P, Simion S, Gradinaru V, Andronescu C, Mastalier B. [The indications for and limits to the surgical treatment of congenital dilatations of the intra- and extrahepatic bile ducts]. Chirurgia (Bucharest, Romania : 1990). 93: 229-38. PMID 9755572  0.07
1997 Andronescu P, Ardelean M, Gradinaru V, Ene V. [Retroperitoneal tumors of nervous origin in adults]. Chirurgia (Bucharest, Romania : 1990). 92: 39-45. PMID 9296746  0.07
2012 Bourquin R, Gradinaru V, Hagedorn GA. Non-adiabatic transitions near avoided crossings: Theory and numerics Journal of Mathematical Chemistry. 50: 602-619. DOI: 10.1007/S10910-011-9827-2  0.066
2010 Gradinaru V, Hagedorn GA, Joye A. Tunneling dynamics and spawning with adaptive semiclassical wave packets Journal of Chemical Physics. 132. DOI: 10.1063/1.3429607  0.059
2023 Zeng J, Wang Y, Luo Z, Chang LC, Yoo JS, Yan H, Choi Y, Xie X, Deverman BE, Gradinaru V, Gupton SL, Zlokovic BV, Zhao Z, Jung JU. TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice. Cell Reports. 42: 113050. PMID 37597183 DOI: 10.1016/j.celrep.2023.113050  0.056
2015 Ion L, Ciobanu CI, Murariu M, Gradinaru VR, Drochioiu G. SDS-induced Peptide Conformational Changes: From Triglycyl-glycine to Amyloid-β Oligomers Associated with Alzheimer’s Disease International Journal of Peptide Research and Therapeutics. DOI: 10.1007/s10989-015-9483-7  0.048
1979 Seicaru T, Gradinaru V. Anatomo-clinical and therapeutic consideration on the non-lithiasic, benign papillo-oddian stenoses Chirurgia. 28: 117-122.  0.048
1981 Seicaru T, Gradinaru V. Anatomo-clinic and therapeutic aspects in the nodular goiter Chirurgia. 30: 115-120.  0.047
1975 Seicaru T, Gradinaru V, Andronescu P. Spontaneous perforations of the pathologic colon (Rumanian) Chirurgia. 24: 273-276.  0.043
1977 Seicaru T, Gradinaru V. Anatamoclinical and therapeutic aspects in liver abscesses Chirurgia. 26: 85-88.  0.037
2013 Gradinaru V, Tutelea L, Boldea I. Hybrid analytical/FEM optimization design of SPMSM for refrigerator compressor loads International Aegean Conference On Electrical Machines and Power Electronics, Acemp 2011 and Electromotion 2011 Joint Conference. 657-662. DOI: 10.1109/ACEMP.2011.6490677  0.037
1980 Gradinaru V, Seicaru T, Radulescu M, Marcov Al.. Suppurated acute obstructive angiocholitis. Anatomo-clinical and therapeutical aspects Chirurgia. 29: 29-39.  0.035
2003 Gradinaru V, Hiptmair R. Multigrid for Discrete Differential forms on Sparse Grids Computing (Vienna/New York). 71: 17-42. DOI: 10.1007/s00607-003-0008-4  0.032
1981 Seicaru T, Gradinaru V. Acute biliary pancreatitis. Anatomo-clinical and therapeutic particularities Chirurgia. 30: 429-439.  0.03
1981 Seicaru T, Gradinaru V. Stenosing papillo-odditis associated to cholelithiasis. Difficulties, errors of diagnostic and particularities of surgical treatment Chirurgia. 30: 279-285.  0.027
2009 Faou E, Gradinaru V. Gauss-Hermite wave packet dynamics: Convergence of the spectral and pseudo-spectral approximation Ima Journal of Numerical Analysis. 29: 1023-1045. DOI: 10.1093/imanum/drn041  0.023
2017 Gradinaru V. Overriding sleep. Science (New York, N.Y.). 358: 457. PMID 29074759 DOI: 10.1126/science.aap9535  0.022
2014 Gradinaru V, Hagedorn GA. Convergence of a semiclassical wavepacket based time-splitting for the Schrödinger equation Numerische Mathematik. 126: 53-73. DOI: 10.1007/S00211-013-0560-6  0.022
1979 Seicaru T, Gradinaru V. Lithiasis of intrahepatic biliary pathways. Problems of diagnosis and therapeutic attitudes Chirurgia. 28: 19-24.  0.021
2007 Gradinaru V. Fourier transform on sparse grids: Code design and the time dependent Schrödinger equation Computing (Vienna/New York). 80: 1-22. DOI: 10.1007/s00607-007-0225-3  0.021
1978 Seicaru T, Gradinaru V. Hydatic cysts of the liver opening in to the biliary pathways. Methods of surgical diagnosis and treatment Chirurgia. 27: 351-353.  0.019
1978 Gradinaru V, Radulescu M, Lotreanu S. Considerations on some surgical aspects of typhoid fevers Viata Medicala. 25: 67-68.  0.019
1999 Gradinaru V, Hiptmair R. Whitney elements on pyramids Electronic Transactions On Numerical Analysis. 8: 154-168.  0.019
1981 Gradinaru V, Seicaru T, Radulescu M. Lithiasic cholecystocholedocal fistulae. Particularities of diagnosis and surgical therapy Chirurgia. 30: 375-380.  0.019
1980 Gradinaru V, Filon V, LotreanuS.. Papillary adenocarcinoma of the biliary pathways Chirurgia. 29: 169-176.  0.018
1976 Seicaru T, Gradinaru V, Radulescu M. Hepato digestive derivations in the treatment of liver cancers with obstruction of intra hepatic biliary pathways (Rumanian) Chirurgia. 25: 97-102.  0.017
1979 Seicaru T, Gradinaru V. Chronic pancreatitis of biliary origin: Particularities of diagnosis and surgical treatment Chirurgia. 28: 171-182.  0.016
1970 Firica T, Gradinaru V, Radulesco M. [Congenital cystic dilatation of the common bile duct]. Acta Gastro-Enterologica Belgica. 33: 657-64. PMID 5511709  0.014
1982 Gradinaru V, Filon V, Seicaru T. Liver tuberculosis. Difficulties of diagnosis and therapy Chirurgia. 31: 125-130.  0.013
2003 Gradinaru V, Hiptmair R. Mixed finite elements on sparse grids Numerische Mathematik. 93: 471-495. DOI: 10.1007/s002110100382  0.012
1973 Gradinaru V, Radulescu M. Considerations on hydatic cysts with muscular locations | CONSIDERATII ASUPRA CHISTURILOR HIDATICE CU LOCALIZARE MUSCULARA Viata Medicala. 20: 307-309.  0.012
1982 Seicaru T, Gradinaru V. Particularities of surgical diagnosis and treatment in lithiasis of the terminal choledocus Chirurgia. 31: 195-204.  0.01
2007 Gradinaru V. Strang splitting for the time-dependent schrödinger equation on sparse grids Siam Journal On Numerical Analysis. 46: 103-123. DOI: 10.1137/050629823  0.01
1982 Gradinaru V, Seicaru T, Radulescu M. Diagnostic difficulties and difficulties in the surgical treatment of cancers of the gall-bladder Chirurgia. 31: 49-56.  0.01
1980 Gradinaru V, Seicaru T, Filon V. Pancreatic lithiasis Chirurgia. 29: 285-293.  0.01
1980 Scicaru T, Gradinaru V. The haemorrhagic post-bulbar ulcer Chirurgia. 29: 349-355.  0.01
1980 Gradinaru V, Seicaru T, Ionescu M, Lotreanu S. Hydatic cyst of the pancreas Chirurgia. 29: 129-133.  0.01
1978 Gradinaru V, Seicaru T, Lotreanu S. Postoperative stenoses of the major biliary pathway. Particularities of diagnosis and surgical attitudes Chirurgia. 27: 275-279.  0.01
1978 Seicaru T, Gradinaru V, Marin MA. Phlegmonous gastritis Chirurgia. 27: 177-179.  0.01
1978 Seicaru T, Gradinaru V. Biliary peritonitis Chirurgia. 27: 409-415.  0.01
1976 Seicaru T, Gradinaru V. Methods of diagnosis and treatment in tumors of the Vater ampula (Rumanian) Chirurgia. 25: 257-262.  0.01
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