Mathew M. Blurton-Jones, Ph.D. - Publications

Neurobiology & Behavior University of California, Irvine, Irvine, CA 
Alzheimer's disease, Parkinson's disease, stem cells

53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Davtyan H, Hovakimyan A, Kiani Shabestari S, Antonyan T, Coburn MA, Zagorski K, Chailyan G, Petrushina I, Svystun O, Danhash E, Petrovsky N, Cribbs DH, Agadjanyan MG, Blurton-Jones M, Ghochikyan A. Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice. Alzheimer's Research & Therapy. 11: 107. PMID 31847886 DOI: 10.1186/s13195-019-0556-2  0.84
2019 Cadete Martini A, Gomez-Arboledas A, Forner S, Rodriguez-Ortiz CJ, McQuade A, Danhash E, Phan J, Javonillo D, Ha JV, Tram M, Trujillo-Estrada L, da Cunha C, Ager RR, Davila JC, Kitazawa M, ... Blurton-Jones M, et al. Amyloid-beta impairs TOM1-mediated IL-1R1 signaling. Proceedings of the National Academy of Sciences of the United States of America. PMID 31570577 DOI: 10.1073/pnas.1914088116  0.92
2019 Hasselmann J, Coburn MA, England W, Figueroa Velez DX, Kiani Shabestari S, Tu CH, McQuade A, Kolahdouzan M, Echeverria K, Claes C, Nakayama T, Azevedo R, Coufal NG, Han CZ, Cummings BJ, ... ... Blurton-Jones M, et al. Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo. Neuron. PMID 31375314 DOI: 10.1016/j.neuron.2019.07.002  0.72
2019 Rojo R, Raper A, Ozdemir DD, Lefevre L, Grabert K, Wollscheid-Lengeling E, Bradford B, Caruso M, Gazova I, Sánchez A, Lisowski ZM, Alves J, Molina-Gonzalez I, Davtyan H, Lodge RJ, ... ... Blurton-Jones M, et al. Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations. Nature Communications. 10: 3215. PMID 31324781 DOI: 10.1038/s41467-019-11053-8  0.64
2019 Faal T, Phan DTT, Davtyan H, Scarfone VM, Varady E, Blurton-Jones M, Hughes CCW, Inlay MA. Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions. Stem Cell Reports. PMID 30745035 DOI: 10.1016/j.stemcr.2019.01.005  0.64
2018 Shukla AK, McIntyre LL, Marsh SE, Schneider CA, Hoover EM, Walsh CM, Lodoen MB, Blurton-Jones M, Inlay MA. CD11a expression distinguishes infiltrating myeloid cells from plaque-associated microglia in Alzheimer's disease. Glia. PMID 30588668 DOI: 10.1002/glia.23575  0.88
2018 McQuade A, Coburn M, Tu CH, Hasselmann J, Davtyan H, Blurton-Jones M. Development and validation of a simplified method to generate human microglia from pluripotent stem cells. Molecular Neurodegeneration. 13: 67. PMID 30577865 DOI: 10.1186/s13024-018-0297-x  0.68
2018 Nakazono T, Jun H, Blurton-Jones M, Green KN, Igarashi KM. Gamma oscillations in the entorhinal-hippocampal circuit underlying memory and dementia. Neuroscience Research. PMID 29438778 DOI: 10.1016/j.neures.2018.02.002  0.68
2017 Reidling JC, Relaño-Ginés A, Holley SM, Ochaba J, Moore C, Fury B, Lau A, Tran AH, Yeung S, Salamati D, Zhu C, Hatami A, Cepeda C, Barry JA, Kamdjou T, ... ... Blurton-Jones M, et al. Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice. Stem Cell Reports. PMID 29233555 DOI: 10.1016/j.stemcr.2017.11.005  0.92
2017 Agadjanyan MG, Zagorski K, Petrushina I, Davtyan H, Kazarian K, Antonenko M, Davis J, Bon C, Blurton-Jones M, Cribbs DH, Ghochikyan A. Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency. Molecular Neurodegeneration. 12: 33. PMID 28472993 DOI: 10.1186/s13024-017-0172-1  0.84
2017 Abud EM, Ramirez RN, Martinez ES, Healy LM, Nguyen CHH, Newman SA, Yeromin AV, Scarfone VM, Marsh SE, Fimbres C, Caraway CA, Fote GM, Madany AM, Agrawal A, Kayed R, ... ... Blurton-Jones M, et al. iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases. Neuron. 94: 278-293.e9. PMID 28426964 DOI: 10.1016/j.neuron.2017.03.042  0.88
2017 Davtyan H, Chen WW, Zagorski K, Davis J, Petrushina I, Kazarian K, Cribbs DH, Agadjanyan MG, Blurton-Jones M, Ghochikyan A. MultiTEP platform-based DNA epitope vaccine targeting N-terminus of tau induces strong immune responses and reduces tau pathology in THY-Tau22 mice. Vaccine. PMID 28320590 DOI: 10.1016/j.vaccine.2017.03.020  0.96
2017 Lakatos A, Goldberg NR, Blurton-Jones M. Integrated analysis of genetic, behavioral, and biochemical data implicates neural stem cell-induced changes in immunity, neurotransmission and mitochondrial function in Dementia with Lewy Body mice. Acta Neuropathologica Communications. 5: 21. PMID 28283027 DOI: 10.1186/s40478-017-0421-0  0.72
2017 Goldberg NR, Marsh SE, Ochaba J, Shelley BC, Davtyan H, Thompson LM, Steffan JS, Svendsen CN, Blurton-Jones M. Human Neural Progenitor Transplantation Rescues Behavior and Reduces α-Synuclein in a Transgenic Model of Dementia with Lewy Bodies. Stem Cells Translational Medicine. PMID 28225193 DOI: 10.1002/sctm.16-0362  0.88
2017 Marsh SE, Blurton-Jones M. Neural stem cell therapy for neurodegenerative disorders: The role of neurotrophic support. Neurochemistry International. PMID 28219641 DOI: 10.1016/j.neuint.2017.02.006  0.88
2017 Marsh SE, Yeung ST, Torres M, Lau L, Davis JL, Monuki ES, Poon WW, Blurton-Jones M. HuCNS-SC Human NSCs Fail to Differentiate, Form Ectopic Clusters, and Provide No Cognitive Benefits in a Transgenic Model of Alzheimer's Disease. Stem Cell Reports. 8: 235-248. PMID 28199828 DOI: 10.1016/j.stemcr.2016.12.019  0.88
2017 Monuki ES, Anderson AJ, Blurton-Jones M, Cummings BJ. Response to StemCells Inc. Stem Cell Reports. 8: 195-197. PMID 28199827 DOI: 10.1016/j.stemcr.2017.02.002  0.32
2016 Chen W, Abud EA, Yeung ST, Lakatos A, Nassi T, Wang J, Blum D, Buée L, Poon WW, Blurton-Jones M. Increased tauopathy drives microglia-mediated clearance of beta-amyloid. Acta Neuropathologica Communications. 4: 63. PMID 27339073 DOI: 10.1186/s40478-016-0336-1  0.72
2016 Spangenberg EE, Lee RJ, Najafi AR, Rice RA, Elmore MR, Blurton-Jones M, West BL, Green KN. Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology. Brain : a Journal of Neurology. PMID 26921617 DOI: 10.1093/brain/aww016  0.96
2016 Marsh SE, Abud EM, Lakatos A, Karimzadeh A, Yeung ST, Davtyan H, Fote GM, Lau L, Weinger JG, Lane TE, Inlay MA, Poon WW, Blurton-Jones M. The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function. Proceedings of the National Academy of Sciences of the United States of America. PMID 26884167 DOI: 10.1073/pnas.1525466113  0.96
2015 Goldberg NR, Caesar J, Park A, Sedgh S, Finogenov G, Masliah E, Davis J, Blurton-Jones M. Neural Stem Cells Rescue Cognitive and Motor Dysfunction in a Transgenic Model of Dementia with Lewy Bodies through a BDNF-Dependent Mechanism. Stem Cell Reports. PMID 26489892 DOI: 10.1016/j.stemcr.2015.09.008  0.96
2015 Ager RR, Davis JL, Agazaryan A, Benavente F, Poon WW, LaFerla FM, Blurton-Jones M. Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss. Hippocampus. 25: 813-26. PMID 25530343 DOI: 10.1002/hipo.22405  0.96
2015 Goldberg NRS, Blurton-Jones M. Can Stem Cells Be Used to Enhance Cognition? Cognitive Enhancement: Pharmacologic, Environmental and Genetic Factors. 167-192. DOI: 10.1016/B978-0-12-417042-1.00008-5  0.96
2014 Blurton-Jones M, Spencer B, Michael S, Castello NA, Agazaryan AA, Davis JL, Müller FJ, Loring JF, Masliah E, LaFerla FM. Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models. Stem Cell Research & Therapy. 5: 46. PMID 25022790 DOI: 10.1186/scrt440  0.96
2013 Rodriguez-Ortiz CJ, Hoshino H, Cheng D, Liu-Yescevitz L, Blurton-Jones M, Wolozin B, LaFerla FM, Kitazawa M. Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice. The American Journal of Pathology. 183: 504-15. PMID 23747512 DOI: 10.1016/j.ajpath.2013.04.014  0.96
2012 Chabrier MA, Blurton-Jones M, Agazaryan AA, Nerhus JL, Martinez-Coria H, LaFerla FM. Soluble aβ promotes wild-type tau pathology in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 17345-50. PMID 23197725 DOI: 10.1523/JNEUROSCI.0172-12.2012  0.96
2012 Chen WW, Blurton-Jones M. Concise review: Can stem cells be used to treat or model Alzheimer's disease? Stem Cells (Dayton, Ohio). 30: 2612-8. PMID 22997040 DOI: 10.1002/stem.1240  0.96
2012 Walls KC, Coskun P, Gallegos-Perez JL, Zadourian N, Freude K, Rasool S, Blurton-Jones M, Green KN, LaFerla FM. Swedish Alzheimer mutation induces mitochondrial dysfunction mediated by HSP60 mislocalization of amyloid precursor protein (APP) and beta-amyloid. The Journal of Biological Chemistry. 287: 30317-27. PMID 22753410 DOI: 10.1074/jbc.M112.365890  0.96
2012 Marsh SE, Blurton-Jones M. Examining the mechanisms that link β-amyloid and α-synuclein pathologies. Alzheimer's Research & Therapy. 4: 11. PMID 22546279 DOI: 10.1186/alzrt109  0.96
2012 Blurton-Jones M, Nerhus JL, LaFerla FM. Transplanting Stem Cells into the Brain Human Stem Cell Manual. 529-542. DOI: 10.1016/B978-0-12-385473-5.00034-5  0.96
2011 Freude KK, Penjwini M, Davis JL, LaFerla FM, Blurton-Jones M. Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells. The Journal of Biological Chemistry. 286: 24264-74. PMID 21606494 DOI: 10.1074/jbc.M111.227421  0.96
2011 Poon WW, Blurton-Jones M, Tu CH, Feinberg LM, Chabrier MA, Harris JW, Jeon NL, Cotman CW. β-Amyloid impairs axonal BDNF retrograde trafficking. Neurobiology of Aging. 32: 821-33. PMID 19540623 DOI: 10.1016/j.neurobiolaging.2009.05.012  0.96
2011 Lopes JP, Blurton-Jones M, Yamasaki TR, Agostinho P, LaFerla FM. Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not aß and tau pathology Advances in Alzheimer's Disease. 1: 139-148. DOI: 10.3233/978-1-60750-733-8-139  0.96
2010 Clinton LK, Blurton-Jones M, Myczek K, Trojanowski JQ, LaFerla FM. Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 7281-9. PMID 20505094 DOI: 10.1523/JNEUROSCI.0490-10.2010  0.96
2010 Koike MA, Green KN, Blurton-Jones M, Laferla FM. Oligemic hypoperfusion differentially affects tau and amyloid-{beta}. The American Journal of Pathology. 177: 300-10. PMID 20472896 DOI: 10.2353/ajpath.2010.090750  0.96
2009 Blurton-Jones M, Kitazawa M, Martinez-Coria H, Castello NA, Müller FJ, Loring JF, Yamasaki TR, Poon WW, Green KN, LaFerla FM. Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 106: 13594-9. PMID 19633196 DOI: 10.1073/pnas.0901402106  0.96
2009 McAlpine FE, Lee JK, Harms AS, Ruhn KA, Blurton-Jones M, Hong J, Das P, Golde TE, LaFerla FM, Oddo S, Blesch A, Tansey MG. Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology. Neurobiology of Disease. 34: 163-77. PMID 19320056 DOI: 10.1016/j.nbd.2009.01.006  0.96
2009 Lopes JP, Blurton-Jones M, Yamasaki TR, Agostinho P, LaFerla FM. Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not amyloid-beta and tau pathology. Journal of Alzheimer's Disease : Jad. 16: 541-9. PMID 19276549 DOI: 10.3233/JAD-2009-0993  0.96
2008 Tseng BP, Green KN, Chan JL, Blurton-Jones M, LaFerla FM. Abeta inhibits the proteasome and enhances amyloid and tau accumulation. Neurobiology of Aging. 29: 1607-18. PMID 17544172 DOI: 10.1016/j.neurobiolaging.2007.04.014  0.96
2007 Yamasaki TR, Blurton-Jones M, Morrissette DA, Kitazawa M, Oddo S, LaFerla FM. Neural stem cells improve memory in an inducible mouse model of neuronal loss. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 11925-33. PMID 17978032 DOI: 10.1523/JNEUROSCI.1627-07.2007  0.96
2007 Shapiro LA, Ng KL, Kinyamu R, Whitaker-Azmitia P, Geisert EE, Blurton-Jones M, Zhou QY, Ribak CE. Origin, migration and fate of newly generated neurons in the adult rodent piriform cortex. Brain Structure & Function. 212: 133-48. PMID 17764016 DOI: 10.1007/s00429-007-0151-3  0.96
2007 Parachikova A, Agadjanyan MG, Cribbs DH, Blurton-Jones M, Perreau V, Rogers J, Beach TG, Cotman CW. Inflammatory changes parallel the early stages of Alzheimer disease. Neurobiology of Aging. 28: 1821-33. PMID 17052803 DOI: 10.1016/j.neurobiolaging.2006.08.014  0.96
2006 Blurton-Jones M, Laferla FM. Pathways by which Abeta facilitates tau pathology. Current Alzheimer Research. 3: 437-48. PMID 17168643 DOI: 10.2174/156720506779025242  0.96
2006 Blurton-Jones M, Tuszynski MH. Estradiol-induced modulation of estrogen receptor-beta and GABA within the adult neocortex: a potential transsynaptic mechanism for estrogen modulation of BDNF. The Journal of Comparative Neurology. 499: 603-12. PMID 17029253 DOI: 10.1002/cne.21122  0.96
2005 Taylor AM, Blurton-Jones M, Rhee SW, Cribbs DH, Cotman CW, Jeon NL. A microfluidic culture platform for CNS axonal injury, regeneration and transport. Nature Methods. 2: 599-605. PMID 16094385 DOI: 10.1038/nmeth777  0.96
2005 Cotman CW, Poon WW, Rissman RA, Blurton-Jones M. The role of caspase cleavage of tau in Alzheimer disease neuropathology. Journal of Neuropathology and Experimental Neurology. 64: 104-12. PMID 15751224  0.96
2004 Cribbs DH, Poon WW, Rissman RA, Blurton-Jones M. Caspase-mediated degeneration in Alzheimer's disease. The American Journal of Pathology. 165: 353-5. PMID 15277211 DOI: 10.1016/S0002-9440(10)63302-0  0.96
2004 Rissman RA, Poon WW, Blurton-Jones M, Oddo S, Torp R, Vitek MP, LaFerla FM, Rohn TT, Cotman CW. Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. The Journal of Clinical Investigation. 114: 121-30. PMID 15232619 DOI: 10.1172/JCI20640  0.96
2004 Blurton-Jones M, Kuan PN, Tuszynski MH. Anatomical evidence for transsynaptic influences of estrogen on brain-derived neurotrophic factor expression. The Journal of Comparative Neurology. 468: 347-60. PMID 14681930 DOI: 10.1002/cne.10989  0.96
2002 Blurton-Jones M, Tuszynski MH. Estrogen receptor-beta colocalizes extensively with parvalbumin-labeled inhibitory neurons in the cortex, amygdala, basal forebrain, and hippocampal formation of intact and ovariectomized adult rats. The Journal of Comparative Neurology. 452: 276-87. PMID 12353223 DOI: 10.1002/cne.10393  0.96
2001 Taber KH, Murphy DD, Blurton-Jones MM, Hurley RA. An update on estrogen: higher cognitive function, receptor mapping, neurotrophic effects. The Journal of Neuropsychiatry and Clinical Neurosciences. 13: 313-7. PMID 11514636 DOI: 10.1176/appi.neuropsych.13.3.313  0.96
2001 Blurton-Jones M, Tuszynski MH. Reactive astrocytes express estrogen receptors in the injured primate brain. The Journal of Comparative Neurology. 433: 115-23. PMID 11283953 DOI: 10.1002/cne.1129  0.4
1999 Blurton-Jones MM, Roberts JA, Tuszynski MH. Estrogen receptor immunoreactivity in the adult primate brain: neuronal distribution and association with p75, trkA, and choline acetyltransferase. The Journal of Comparative Neurology. 405: 529-42. PMID 10098943 DOI: 10.1002/(SICI)1096-9861(19990322)405:4<529::AID-CNE6>3.0.CO;2-Y  0.96
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