Stefan Prokop - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
Microglia, Neurodegeneration, Alzheimer, Parkinsons

36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Xia Y, Prokop S, Gorion KM, Kim JD, Sorrentino ZA, Bell BM, Manaois AN, Chakrabarty P, Davies P, Giasson BI. Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer's disease and other tauopathies. Acta Neuropathologica Communications. 8: 88. PMID 32571418 DOI: 10.1186/s40478-020-00967-w  0.56
2020 Drost N, Houtman J, Cseresnyés Z, Niesner R, Rinnenthal JL, Miller KR, Prokop S, Heppner FL. The Amyloid-beta rich CNS environment alters myeloid cell functionality independent of their origin. Scientific Reports. 10: 7152. PMID 32346002 DOI: 10.1038/s41598-020-63989-3  0.64
2020 Lloyd GM, Trejo-Lopez JA, Xia Y, McFarland KN, Lincoln SJ, Ertekin-Taner N, Giasson BI, Yachnis AT, Prokop S. Prominent amyloid plaque pathology and cerebral amyloid angiopathy in APP V717I (London) carrier - phenotypic variability in autosomal dominant Alzheimer's disease. Acta Neuropathologica Communications. 8: 31. PMID 32164763 DOI: 10.1186/s40478-020-0891-3  0.56
2020 Trejo-Lopez JA, Sorrentino ZA, Riffe CJ, Prokop S, Dickson DW, Yachnis AT, Giasson BI. Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases. Journal of Neuropathology and Experimental Neurology. PMID 32106300 DOI: 10.1093/jnen/nlaa007  0.56
2020 Eede P, Obst J, Benke E, Yvon-Durocher G, Richard BC, Gimber N, Schmoranzer J, Böddrich A, Wanker EE, Prokop S, Heppner FL. Interleukin-12/23 deficiency differentially affects pathology in male and female Alzheimer's disease-like mice. Embo Reports. e48530. PMID 32003148 DOI: 10.15252/embr.201948530  0.64
2019 Prokop S, Lee VMY, Trojanowski JQ. Neuroimmune interactions in Alzheimer's disease-New frontier with old challenges? Progress in Molecular Biology and Translational Science. 168: 183-201. PMID 31699314 DOI: 10.1016/bs.pmbts.2019.10.002  0.64
2019 Sacino AN, Prokop S, Walsh MA, Adamson J, Subramony SH, Krans A, Todd PK, Giasson BI, Yachnis AT. Fragile X-associated tremor ataxia syndrome with co-occurrent progressive supranuclear palsy-like neuropathology. Acta Neuropathologica Communications. 7: 158. PMID 31665069 DOI: 10.1186/s40478-019-0818-z  0.56
2019 Prokop S, Miller KR, Labra SR, Pitkin RM, Hoxha K, Narasimhan S, Changolkar L, Rosenbloom A, Lee VM, Trojanowski JQ. Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples. Acta Neuropathologica. PMID 31350575 DOI: 10.1007/s00401-019-02048-2  0.64
2017 Wagner LK, Gilling KE, Schormann E, Kloetzel PM, Heppner FL, Krüger E, Prokop S. Immunoproteasome deficiency alters microglial cytokine response and improves cognitive deficits in Alzheimer's disease-like APPPS1 mice. Acta Neuropathologica Communications. 5: 52. PMID 28646899 DOI: 10.1186/s40478-017-0453-5  0.64
2016 Baufeld C, Osterloh A, Prokop S, Miller KR, Heppner FL. High-fat diet-induced brain region-specific phenotypic spectrum of CNS resident microglia. Acta Neuropathologica. PMID 27393312 DOI: 10.1007/s00401-016-1595-4  0.64
2015 Prokop S, Miller KR, Drost N, Handrick S, Mathur V, Luo J, Wegner A, Wyss-Coray T, Heppner FL. Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer's disease-like mice. The Journal of Experimental Medicine. 212: 1811-8. PMID 26458768 DOI: 10.1084/jem.20150479  0.64
2015 Naumann RK, Ray S, Prokop S, Las L, Heppner FL, Brecht M. Conserved size & periodicity of pyramidal patches in layer 2 of medial/caudal entorhinal cortex. The Journal of Comparative Neurology. PMID 26223342 DOI: 10.1002/cne.23865  0.64
2015 Hoffmann O, Rung O, Held J, Boettcher C, Prokop S, Stenzel W, Priller J. Lymphocytes modulate innate immune responses and neuronal damage in experimental meningitis. Infection and Immunity. 83: 259-67. PMID 25348636 DOI: 10.1128/IAI.02682-14  0.64
2015 Johansson LB, Simon R, Bergström G, Eriksson M, Prokop S, Mandenius CF, Heppner FL, Åslund AK, Nilsson KP. An azide functionalized oligothiophene ligand--a versatile tool for multimodal detection of disease associated protein aggregates. Biosensors & Bioelectronics. 63: 204-11. PMID 25089818 DOI: 10.1016/j.bios.2014.07.042  0.64
2014 Barucker C, Harmeier A, Weiske J, Fauler B, Albring KF, Prokop S, Hildebrand P, Lurz R, Heppner FL, Huber O, Multhaup G. Nuclear translocation uncovers the amyloid peptide Aβ42 as a regulator of gene transcription. The Journal of Biological Chemistry. 289: 20182-91. PMID 24878959 DOI: 10.1074/jbc.M114.564690  0.64
2014 Schröder NW, Grieben U, Prokop S, Dekomien G, Epplen JT, Heppner FL, Goebel HH, Stenzel W. Novel γ-sarcoglycan-mutation affects cardiac function and N-terminal dystrophin expression. Muscle & Nerve. 49: 144-5. PMID 23929688 DOI: 10.1002/mus.23981  0.64
2013 Prokop S, Miller KR, Heppner FL. Microglia actions in Alzheimer’s disease. Acta Neuropathologica. 126: 461-77. PMID 24224195 DOI: 10.1007/s00401-013-1182-x  0.64
2013 Krabbe G, Halle A, Matyash V, Rinnenthal JL, Eom GD, Bernhardt U, Miller KR, Prokop S, Kettenmann H, Heppner FL. Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology. Plos One. 8: e60921. PMID 23577177 DOI: 10.1371/journal.pone.0060921  0.64
2013 Nyström S, Psonka-Antonczyk KM, Ellingsen PG, Johansson LB, Reitan N, Handrick S, Prokop S, Heppner FL, Wegenast-Braun BM, Jucker M, Lindgren M, Stokke BT, Hammarström P, Nilsson KP. Evidence for age-dependent in vivo conformational rearrangement within Aβ amyloid deposits. Acs Chemical Biology. 8: 1128-33. PMID 23521783 DOI: 10.1021/cb4000376  0.64
2013 Arja K, Sjölander D, Ã…slund A, Prokop S, Heppner FL, Konradsson P, Lindgren M, Hammarström P, Ã…slund KO, Nilsson KP. Enhanced fluorescent assignment of protein aggregates by an oligothiophene-porphyrin-based amyloid ligand. Macromolecular Rapid Communications. 34: 723-30. PMID 23468206 DOI: 10.1002/marc.201200817  0.64
2013 Klingstedt T, Blechschmidt C, Nogalska A, Prokop S, Häggqvist B, Danielsson O, Engel WK, Askanas V, Heppner FL, Nilsson KP. Luminescent conjugated oligothiophenes for sensitive fluorescent assignment of protein inclusion bodies. Chembiochem : a European Journal of Chemical Biology. 14: 607-16. PMID 23450708 DOI: 10.1002/cbic.201200731  0.64
2012 Vom Berg J, Prokop S, Miller KR, Obst J, Kälin RE, Lopategui-Cabezas I, Wegner A, Mair F, Schipke CG, Peters O, Winter Y, Becher B, Heppner FL. Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline. Nature Medicine. 18: 1812-9. PMID 23178247 DOI: 10.1038/nm.2965  0.64
2011 Opitz E, Koch A, Klingel K, Schmidt F, Prokop S, Rahnefeld A, Sauter M, Heppner FL, Völker U, Kandolf R, Kuckelkorn U, Stangl K, Krüger E, Kloetzel PM, Voigt A. Impairment of immunoproteasome function by β5i/LMP7 subunit deficiency results in severe enterovirus myocarditis. Plos Pathogens. 7: e1002233. PMID 21909276 DOI: 10.1371/journal.ppat.1002233  0.64
2011 Schipke CG, Jessen F, Teipel S, Luckhaus C, Wiltfang J, Esselmann H, Frölich L, Maier W, Rüther E, Heppner FL, Prokop S, Heuser I, Peters O. Long-term stability of Alzheimer's disease biomarker proteins in cerebrospinal fluid. Journal of Alzheimer's Disease : Jad. 26: 255-62. PMID 21606567 DOI: 10.3233/JAD-2011-110329  0.64
2011 Prokop S, Heppner FL, Goebel HH, Stenzel W. M2 polarized macrophages and giant cells contribute to myofibrosis in neuromuscular sarcoidosis. The American Journal of Pathology. 178: 1279-86. PMID 21356378 DOI: 10.1016/j.ajpath.2010.11.065  0.64
2011 Polymenidou M, Prokop S, Jung HH, Hewer E, Peretz D, Moos R, Tolnay M, Aguzzi A. Atypical prion protein conformation in familial prion disease with PRNP P105T mutation. Brain Pathology (Zurich, Switzerland). 21: 209-14. PMID 20875062 DOI: 10.1111/j.1750-3639.2010.00439.x  0.32
2010 Stenzel W, Prokop S, Kress W, Huppmann S, Loui A, Sarioglu NM, Laing NG, Sparrow JC, Heppner FL, Goebel HH. Fetal akinesia caused by a novel actin filament aggregate myopathy skeletal muscle actin gene (ACTA1) mutation. Neuromuscular Disorders : Nmd. 20: 531-3. PMID 20621480 DOI: 10.1016/j.nmd.2010.06.008  0.64
2009 Grathwohl SA, Kälin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, Odenthal J, Radde R, Eldh T, Gandy S, Aguzzi A, Staufenbiel M, Mathews PM, Wolburg H, Heppner FL, et al. Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nature Neuroscience. 12: 1361-3. PMID 19838177 DOI: 10.1038/nn.2432  0.64
2009 Aslund A, Sigurdson CJ, Klingstedt T, Grathwohl S, Bolmont T, Dickstein DL, Glimsdal E, Prokop S, Lindgren M, Konradsson P, Holtzman DM, Hof PR, Heppner FL, Gandy S, Jucker M, et al. Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses. Acs Chemical Biology. 4: 673-84. PMID 19624097 DOI: 10.1021/cb900112v  0.64
2005 Prokop S, Haass C, Steiner H. Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments. Journal of Neurochemistry. 94: 57-62. PMID 15953349 DOI: 10.1111/j.1471-4159.2005.03165.x  0.64
2005 Capell A, Beher D, Prokop S, Steiner H, Kaether C, Shearman MS, Haass C. Gamma-secretase complex assembly within the early secretory pathway. The Journal of Biological Chemistry. 280: 6471-8. PMID 15591316 DOI: 10.1074/jbc.M409106200  0.64
2004 Shirotani K, Edbauer D, Prokop S, Haass C, Steiner H. Identification of distinct gamma-secretase complexes with different APH-1 variants. The Journal of Biological Chemistry. 279: 41340-5. PMID 15286082 DOI: 10.1074/jbc.M405768200  0.64
2004 Prokop S, Shirotani K, Edbauer D, Haass C, Steiner H. Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex. The Journal of Biological Chemistry. 279: 23255-61. PMID 15039426 DOI: 10.1074/jbc.M401789200  0.64
2002 Steiner H, Winkler E, Edbauer D, Prokop S, Basset G, Yamasaki A, Kostka M, Haass C. PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin. The Journal of Biological Chemistry. 277: 39062-5. PMID 12198112 DOI: 10.1074/jbc.C200469200  0.6
0 Prokop S. . PMID 27393312  0.56
0 Prokop S. . PMID 26458768  0.4
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