Fred Van Leuven - Publications

Affiliations: 
Experimental Genetics Group  Katholieke Universiteit Leuven, Leuven, Vlaanderen, Belgium 
Website:
http://med.kuleuven.be/legtegg/

293 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Govaerts K, Lechat B, Struys T, Kremer A, Borghgraef P, Van Leuven F, Himmelreich U, Dresselaers T. Longitudinal assessment of cerebral perfusion and vascular response to hypoventilation in a bigenic mouse model of Alzheimer's disease with amyloid and tau pathology. Nmr in Biomedicine. 32: e4037. PMID 30489666 DOI: 10.1002/nbm.4037  0.44
2016 Theunis C, Adolfsson O, Crespo-Biel N, Piorkowska K, Pihlgren M, Hickman DT, Gafner V, Borghgraef P, Devijver H, Pfeifer A, Van Leuven F, Muhs A. Novel Phospho-Tau Monoclonal Antibody Generated Using a Liposomal Vaccine, with Enhanced Recognition of a Conformational Tauopathy Epitope. Journal of Alzheimer's Disease : Jad. PMID 28035925 DOI: 10.3233/JAD-160695  0.44
2016 Brendel M, Jaworska A, Probst F, Overhoff F, Korzhova V, Lindner S, Carlsen J, Bartenstein P, Harada R, Kudo Y, Haass C, van Leuven F, Okamura N, Herms J, Rominger A. microPET Imaging of Tau Pathology with [18F]-THK5117 in two Transgenic Mouse Models. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 26912432 DOI: 10.2967/jnumed.115.163493  0.84
2016 Kondratiuk I, Łęski S, Urbańska M, Biecek P, Devijver H, Lechat B, Van Leuven F, Kaczmarek L, Jaworski T. GSK-3β and MMP-9 Cooperate in the Control of Dendritic Spine Morphology. Molecular Neurobiology. PMID 26738851 DOI: 10.1007/s12035-015-9625-0  0.84
2015 Staats KA, Pombal D, Schönefeldt S, Van Helleputte L, Maurin H, Dresselaers T, Govaerts K, Himmelreich U, Van Leuven F, Van Den Bosch L, Dooley J, Humblet-Baron S, Liston A. Transcriptional upregulation of myelin components in spontaneous myelin basic protein-deficient mice. Brain Research. 1606: 125-32. PMID 25708149 DOI: 10.1016/j.brainres.2015.02.021  0.84
2015 Ochs SM, Dorostkar MM, Aramuni G, Schön C, Filser S, Pöschl J, Kremer A, Van Leuven F, Ovsepian SV, Herms J. Loss of neuronal GSK3β reduces dendritic spine stability and attenuates excitatory synaptic transmission via β-catenin. Molecular Psychiatry. 20: 482-9. PMID 24912492 DOI: 10.1038/mp.2014.55  0.84
2014 Kukreja L, Kujoth GC, Prolla TA, Van Leuven F, Vassar R. Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease. Molecular Neurodegeneration. 9: 16. PMID 24885175 DOI: 10.1186/1750-1326-9-16  0.84
2014 Maurin H, Lechat B, Borghgraef P, Devijver H, Jaworski T, Van Leuven F. Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3α/β. The European Journal of Neuroscience. 40: 2442-53. PMID 24754737 DOI: 10.1111/ejn.12595  0.84
2014 Crespo-Biel N, Theunis C, Borghgraef P, Lechat B, Devijver H, Maurin H, Van Leuven F. Phosphorylation of protein Tau by GSK3β prolongs survival of bigenic Tau.P301L×GSK3β mice by delaying brainstem tauopathy. Neurobiology of Disease. 67: 119-32. PMID 24704314 DOI: 10.1016/j.nbd.2014.03.016  0.84
2014 Maurin H, Chong SA, Kraev I, Davies H, Kremer A, Seymour CM, Lechat B, Jaworski T, Borghgraef P, Devijver H, Callewaert G, Stewart MG, Van Leuven F. Early structural and functional defects in synapses and myelinated axons in stratum lacunosum moleculare in two preclinical models for tauopathy. Plos One. 9: e87605. PMID 24498342 DOI: 10.1371/journal.pone.0087605  0.84
2014 Lastres-Becker I, Innamorato NG, Jaworski T, Rábano A, Kügler S, Van Leuven F, Cuadrado A. Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis. Brain : a Journal of Neurology. 137: 78-91. PMID 24277722 DOI: 10.1093/brain/awt323  0.84
2013 Borghgraef P, Menuet C, Theunis C, Louis JV, Devijver H, Maurin H, Smet-Nocca C, Lippens G, Hilaire G, Gijsen H, Moechars D, Van Leuven F. Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice. Plos One. 8: e84442. PMID 24376810 DOI: 10.1371/journal.pone.0084442  0.84
2013 Theunis C, Crespo-Biel N, Gafner V, Pihlgren M, López-Deber MP, Reis P, Hickman DT, Adolfsson O, Chuard N, Ndao DM, Borghgraef P, Devijver H, Van Leuven F, Pfeifer A, Muhs A. Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau.P301L mice that model tauopathy. Plos One. 8: e72301. PMID 23977276 DOI: 10.1371/journal.pone.0072301  0.84
2013 Maurin H, Lechat B, Dewachter I, Ris L, Louis JV, Borghgraef P, Devijver H, Jaworski T, Van Leuven F. Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase. Molecular Brain. 6: 27. PMID 23705847 DOI: 10.1186/1756-6606-6-27  0.84
2013 Maurin H, Seymour CM, Lechat B, Borghgraef P, Devijver H, Jaworski T, Schmidt MV, Kuegler S, Van Leuven F. Tauopathy differentially affects cell adhesion molecules in mouse brain: early down-regulation of nectin-3 in stratum lacunosum moleculare. Plos One. 8: e63589. PMID 23704923 DOI: 10.1371/journal.pone.0063589  0.84
2013 Kondratiuk I, Devijver H, Lechat B, Van Leuven F, Kaczmarek L, Filipkowski RK. Glycogen synthase kinase-3beta affects size of dentate gyrus and species-typical behavioral tasks in transgenic and knockout mice. Behavioural Brain Research. 248: 46-50. PMID 23570858 DOI: 10.1016/j.bbr.2013.03.045  0.84
2013 Barao S, Zhou L, Adamczuk K, Vanhoutvin T, van Leuven F, Demedts D, Vijverman AC, Bossuyt X, Vandenberghe R, De Strooper B. BACE1 levels correlate with phospho-tau levels in human cerebrospinal fluid. Current Alzheimer Research. 10: 671-8. PMID 23566348 DOI: 10.2174/15672050113109990138  0.84
2013 Gandy JC, Melendez-Ferro M, Bijur GN, Van Leuven F, Roche JK, Lechat B, Devijver H, Demedts D, Perez-Costas E, Roberts RC. Glycogen synthase kinase-3β (GSK3β) expression in a mouse model of Alzheimer's disease: a light and electron microscopy study. Synapse (New York, N.Y.). 67: 313-27. PMID 23390016 DOI: 10.1002/syn.21642  0.84
2012 Parr C, Carzaniga R, Gentleman SM, Van Leuven F, Walter J, Sastre M. Glycogen synthase kinase 3 inhibition promotes lysosomal biogenesis and autophagic degradation of the amyloid-β precursor protein. Molecular and Cellular Biology. 32: 4410-8. PMID 22927642 DOI: 10.1128/MCB.00930-12  0.84
2012 Rada P, Rojo AI, Evrard-Todeschi N, Innamorato NG, Cotte A, Jaworski T, Tobón-Velasco JC, Devijver H, García-Mayoral MF, Van Leuven F, Hayes JD, Bertho G, Cuadrado A. Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis. Molecular and Cellular Biology. 32: 3486-99. PMID 22751928 DOI: 10.1128/MCB.00180-12  0.84
2012 Crespo-Biel N, Theunis C, Van Leuven F. Protein tau: prime cause of synaptic and neuronal degeneration in Alzheimer's disease. International Journal of Alzheimer's Disease. 2012: 251426. PMID 22720188 DOI: 10.1155/2012/251426  0.84
2012 Lo Monte F, Kramer T, Gu J, Anumala UR, Marinelli L, La Pietra V, Novellino E, Franco B, Demedts D, Van Leuven F, Fuertes A, Dominguez JM, Plotkin B, Eldar-Finkelman H, Schmidt B. Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3α. Journal of Medicinal Chemistry. 55: 4407-24. PMID 22533818 DOI: 10.1021/jm300309a  0.84
2012 Menuet C, Borghgraef P, Voituron N, Gestreau C, Gielis L, Devijver H, Dutschmann M, Van Leuven F, Hilaire G. Isoflurane anesthesia precipitates tauopathy and upper airways dysfunction in pre-symptomatic Tau.P301L mice: possible implication for neurodegenerative diseases. Neurobiology of Disease. 46: 234-43. PMID 22316605 DOI: 10.1016/j.nbd.2012.01.012  0.84
2011 Kiryk A, Mochol G, Filipkowski RK, Wawrzyniak M, Lioudyno V, Knapska E, Gorkiewicz T, Balcerzyk M, Leski S, Leuven FV, Lipp HP, Wojcik DK, Kaczmarek L. Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm. Current Alzheimer Research. 8: 883-92. PMID 22171952 DOI: 10.2174/156720511798192745  0.84
2011 Kremer A, Maurin H, Demedts D, Devijver H, Borghgraef P, Van Leuven F. Early improved and late defective cognition is reflected by dendritic spines in Tau.P301L mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 18036-47. PMID 22159117 DOI: 10.1523/JNEUROSCI.4859-11.2011  0.84
2011 Jaworski T, Dewachter I, Lechat B, Gees M, Kremer A, Demedts D, Borghgraef P, Devijver H, Kügler S, Patel S, Woodgett JR, Van Leuven F. GSK-3α/β kinases and amyloid production in vivo. Nature. 480: E4-5; discussion E6. PMID 22158250 DOI: 10.1038/nature10615  0.84
2011 Menuet C, Cazals Y, Gestreau C, Borghgraef P, Gielis L, Dutschmann M, Van Leuven F, Hilaire G. Age-related impairment of ultrasonic vocalization in Tau.P301L mice: possible implication for progressive language disorders. Plos One. 6: e25770. PMID 22022446 DOI: 10.1371/journal.pone.0025770  0.84
2011 Jung CK, Fuhrmann M, Honarnejad K, Van Leuven F, Herms J. Role of presenilin 1 in structural plasticity of cortical dendritic spines in vivo. Journal of Neurochemistry. 119: 1064-73. PMID 21951279 DOI: 10.1111/j.1471-4159.2011.07503.x  0.84
2011 Kremer A, Louis JV, Jaworski T, Van Leuven F. GSK3 and Alzheimer's Disease: Facts and Fiction…. Frontiers in Molecular Neuroscience. 4: 17. PMID 21904524 DOI: 10.3389/fnmol.2011.00017  0.44
2011 Jaworski T, Lechat B, Demedts D, Gielis L, Devijver H, Borghgraef P, Duimel H, Verheyen F, Kügler S, Van Leuven F. Dendritic degeneration, neurovascular defects, and inflammation precede neuronal loss in a mouse model for tau-mediated neurodegeneration. The American Journal of Pathology. 179: 2001-15. PMID 21839061 DOI: 10.1016/j.ajpath.2011.06.025  0.84
2011 Chong SA, Benilova I, Shaban H, De Strooper B, Devijver H, Moechars D, Eberle W, Bartic C, Van Leuven F, Callewaert G. Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: a multi-electrode array study. Neurobiology of Disease. 44: 284-91. PMID 21807097 DOI: 10.1016/j.nbd.2011.07.006  0.84
2011 Menuet C, Borghgraef P, Matarazzo V, Gielis L, Lajard AM, Voituron N, Gestreau C, Dutschmann M, Van Leuven F, Hilaire G. Raphé tauopathy alters serotonin metabolism and breathing activity in terminal Tau.P301L mice: possible implications for tauopathies and Alzheimer's disease. Respiratory Physiology & Neurobiology. 178: 290-303. PMID 21763469 DOI: 10.1016/j.resp.2011.06.030  0.84
2011 Rat D, Schmitt U, Tippmann F, Dewachter I, Theunis C, Wieczerzak E, Postina R, van Leuven F, Fahrenholz F, Kojro E. Neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) slows down Alzheimer's disease-like pathology in amyloid precursor protein-transgenic mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 3208-18. PMID 21593432 DOI: 10.1096/fj.10-180133  0.84
2011 Zhou L, Brouwers N, Benilova I, Vandersteen A, Mercken M, Van Laere K, Van Damme P, Demedts D, Van Leuven F, Sleegers K, Broersen K, Van Broeckhoven C, Vandenberghe R, De Strooper B. Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation. Embo Molecular Medicine. 3: 291-302. PMID 21500352 DOI: 10.1002/emmm.201100138  0.84
2011 Louis JV, Martens E, Borghgraef P, Lambrecht C, Sents W, Longin S, Zwaenepoel K, Pijnenborg R, Landrieu I, Lippens G, Ledermann B, Götz J, Van Leuven F, Goris J, Janssens V. Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta. Proceedings of the National Academy of Sciences of the United States of America. 108: 6957-62. PMID 21482799 DOI: 10.1073/pnas.1018777108  0.84
2011 Everaerts W, Gees M, Alpizar YA, Farre R, Leten C, Apetrei A, Dewachter I, van Leuven F, Vennekens R, De Ridder D, Nilius B, Voets T, Talavera K. The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil. Current Biology : Cb. 21: 316-21. PMID 21315593 DOI: 10.1016/j.cub.2011.01.031  0.84
2011 Rolyan H, Feike AC, Upadhaya AR, Waha A, Van Dooren T, Haass C, Birkenmeier G, Pietrzik CU, Van Leuven F, Thal DR. Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer's disease. Journal of Neural Transmission (Vienna, Austria : 1996). 118: 699-712. PMID 21210284 DOI: 10.1007/s00702-010-0572-7  0.84
2011 Osorio-Garcia MI, Sima DM, Nielsen FU, Dresselaers T, Van Leuven F, Himmelreich U, Van Huffel S. Quantification of in vivo 1H magnetic resonance spectroscopy signals with baseline and lineshape estimation Measurement Science and Technology. 22. DOI: 10.1088/0957-0233/22/11/114011  0.84
2010 Philips T, De Muynck L, Thu HN, Weynants B, Vanacker P, Dhondt J, Sleegers K, Schelhaas HJ, Verbeek M, Vandenberghe R, Sciot R, Van Broeckhoven C, Lambrechts D, Van Leuven F, Van Den Bosch L, et al. Microglial upregulation of progranulin as a marker of motor neuron degeneration. Journal of Neuropathology and Experimental Neurology. 69: 1191-200. PMID 21107132 DOI: 10.1097/NEN.0b013e3181fc9aea  0.84
2010 Tanghe A, Termont A, Merchiers P, Schilling S, Demuth HU, Scrocchi L, Van Leuven F, Griffioen G, Van Dooren T. Pathological Hallmarks, Clinical Parallels, and Value for Drug Testing in Alzheimer's Disease of the APP[V717I] London Transgenic Mouse Model. International Journal of Alzheimer's Disease. 2010. PMID 20862386 DOI: 10.4061/2010/417314  0.84
2010 Jaworski T, Kügler S, Van Leuven F. Modeling of tau-mediated synaptic and neuronal degeneration in Alzheimer's disease. International Journal of Alzheimer's Disease. 2010. PMID 20862366 DOI: 10.4061/2010/573138  0.84
2010 Hillen H, Barghorn S, Striebinger A, Labkovsky B, Müller R, Nimmrich V, Nolte MW, Perez-Cruz C, van der Auwera I, van Leuven F, van Gaalen M, Bespalov AY, Schoemaker H, Sullivan JP, Ebert U. Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 10369-79. PMID 20685980 DOI: 10.1523/JNEUROSCI.5721-09.2010  0.84
2010 Vanhelmont T, Vandebroek T, De Vos A, Terwel D, Lemaire K, Anandhakumar J, Franssens V, Swinnen E, Van Leuven F, Winderickx J. Serine-409 phosphorylation and oxidative damage define aggregation of human protein tau in yeast. Fems Yeast Research. 10: 992-1005. PMID 20662935 DOI: 10.1111/j.1567-1364.2010.00662.x  0.84
2010 Jaworski T, Dewachter I, Seymour CM, Borghgraef P, Devijver H, Kügler S, Van Leuven F. Alzheimer's disease: old problem, new views from transgenic and viral models. Biochimica Et Biophysica Acta. 1802: 808-18. PMID 20332023 DOI: 10.1016/j.bbadis.2010.03.005  0.84
2010 Sala Frigerio C, Fadeeva JV, Minogue AM, Citron M, Van Leuven F, Staufenbiel M, Paganetti P, Selkoe DJ, Walsh DM. beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins. The Febs Journal. 277: 1503-18. PMID 20163459 DOI: 10.1111/j.1742-4658.2010.07579.x  0.84
2010 Dutschmann M, Menuet C, Stettner GM, Gestreau C, Borghgraef P, Devijver H, Gielis L, Hilaire G, Van Leuven F. Upper airway dysfunction of Tau-P301L mice correlates with tauopathy in midbrain and ponto-medullary brainstem nuclei. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 1810-21. PMID 20130190 DOI: 10.1523/JNEUROSCI.5261-09.2010  0.84
2010 Larbanoix L, Burtea C, Laurent S, Van Leuven F, Toubeau G, Vander Elst L, Muller RN. Potential amyloid plaque-specific peptides for the diagnosis of Alzheimer's disease. Neurobiology of Aging. 31: 1679-89. PMID 19027991 DOI: 10.1016/j.neurobiolaging.2008.09.021  0.84
2009 Jaworski T, Dewachter I, Lechat B, Croes S, Termont A, Demedts D, Borghgraef P, Devijver H, Filipkowski RK, Kaczmarek L, Kügler S, Van Leuven F. AAV-tau mediates pyramidal neurodegeneration by cell-cycle re-entry without neurofibrillary tangle formation in wild-type mice. Plos One. 4: e7280. PMID 19794916 DOI: 10.1371/journal.pone.0007280  0.84
2009 Jansen PJ, Lütjohann D, Thelen KM, von Bergmann K, van Leuven F, Ramaekers FC, Monique M. Absence of ApoE upregulates murine brain ApoD and ABCA1 levels, but does not affect brain sterol levels, while human ApoE3 and human ApoE4 upregulate brain cholesterol precursor levels. Journal of Alzheimer's Disease : Jad. 18: 319-29. PMID 19584433 DOI: 10.3233/JAD-2009-1150  0.84
2009 Lim JC, Mickute Z, Zaman M, Hopkins S, Wijesuriya H, Steckler T, Moechars D, Van Leuven F, Sarnyai Z, Hladky SB, Barrand MA. Decreased expression of multidrug efflux transporters in the brains of GSK-3beta transgenic mice. Brain Research. 1276: 1-10. PMID 19393634 DOI: 10.1016/j.brainres.2009.04.031  0.84
2009 Dewachter I, Ris L, Jaworski T, Seymour CM, Kremer A, Borghgraef P, De Vijver H, Godaux E, Van Leuven F. GSK3beta, a centre-staged kinase in neuropsychiatric disorders, modulates long term memory by inhibitory phosphorylation at serine-9. Neurobiology of Disease. 35: 193-200. PMID 19379814 DOI: 10.1016/j.nbd.2009.04.003  0.84
2009 Serdons K, Verduyckt T, Vanderghinste D, Borghgraef P, Cleynhens J, Van Leuven F, Kung H, Bormans G, Verbruggen A. 11C-labelled PIB analogues as potential tracer agents for in vivo imaging of amyloid beta in Alzheimer's disease. European Journal of Medicinal Chemistry. 44: 1415-26. PMID 18992967 DOI: 10.1016/j.ejmech.2008.09.038  0.84
2009 Dewachter I, Filipkowski RK, Priller C, Ris L, Neyton J, Croes S, Terwel D, Gysemans M, Devijver H, Borghgraef P, Godaux E, Kaczmarek L, Herms J, Van Leuven F. Deregulation of NMDA-receptor function and down-stream signaling in APP[V717I] transgenic mice. Neurobiology of Aging. 30: 241-56. PMID 17673336 DOI: 10.1016/j.neurobiolaging.2007.06.011  0.84
2009 Serdons K, Vanderghinste D, Van Eeckhoudt M, Borghgraef P, Kung H, Van Leuven F, De Groot T, Bormans G, Verbruggen A. Synthesis and evaluation of two fluorine-18 labelled phenylbenzothiazoles as potential in vivo tracers for amyloid plaque imaging Journal of Labelled Compounds and Radiopharmaceuticals. 52: 473-481. DOI: 10.1002/jlcr.1662  0.84
2008 Tamboli IY, Prager K, Thal DR, Thelen KM, Dewachter I, Pietrzik CU, St George-Hyslop P, Sisodia SS, De Strooper B, Heneka MT, Filippov MA, Müller U, van Leuven F, Lütjohann D, Walter J. Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12097-106. PMID 19005074 DOI: 10.1523/JNEUROSCI.2635-08.2008  0.84
2008 Zabrocki P, Bastiaens I, Delay C, Bammens T, Ghillebert R, Pellens K, De Virgilio C, Van Leuven F, Winderickx J. Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson. Biochimica Et Biophysica Acta. 1783: 1767-80. PMID 18634833 DOI: 10.1016/j.bbamcr.2008.06.010  0.84
2008 Hirata-Fukae C, Sidahmed EH, Gooskens TP, Aisen PS, Dewachter I, Devijver H, Van Leuven F, Matsuoka Y. Beta-site amyloid precursor protein-cleaving enzyme-1 (BACE1)-mediated changes of endogenous amyloid beta in wild-type and transgenic mice in vivo. Neuroscience Letters. 435: 186-9. PMID 18343582 DOI: 10.1016/j.neulet.2008.02.032  0.84
2008 Winderickx J, Delay C, De Vos A, Klinger H, Pellens K, Vanhelmont T, Van Leuven F, Zabrocki P. Protein folding diseases and neurodegeneration: lessons learned from yeast. Biochimica Et Biophysica Acta. 1783: 1381-95. PMID 18298958 DOI: 10.1016/j.bbamcr.2008.01.020  0.84
2008 Terwel D, Muyllaert D, Dewachter I, Borghgraef P, Croes S, Devijver H, Van Leuven F. Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice. The American Journal of Pathology. 172: 786-98. PMID 18258852 DOI: 10.2353/ajpath.2008.070904  0.84
2008 Muyllaert D, Terwel D, Kremer A, Sennvik K, Borghgraef P, Devijver H, Dewachter I, Van Leuven F. Neurodegeneration and neuroinflammation in cdk5/p25-inducible mice: a model for hippocampal sclerosis and neocortical degeneration. The American Journal of Pathology. 172: 470-85. PMID 18202185 DOI: 10.2353/ajpath.2008.070693  0.84
2008 Muyllaert D, Kremer A, Jaworski T, Borghgraef P, Devijver H, Croes S, Dewachter I, Van Leuven F. Glycogen synthase kinase-3beta, or a link between amyloid and tau pathology? Genes, Brain, and Behavior. 7: 57-66. PMID 18184370 DOI: 10.1111/j.1601-183X.2007.00376.x  0.84
2008 Dewachter I, Ris L, Croes S, Borghgraef P, Devijver H, Voets T, Nilius B, Godaux E, Van Leuven F. Modulation of synaptic plasticity and Tau phosphorylation by wild-type and mutant presenilin1. Neurobiology of Aging. 29: 639-52. PMID 17222948 DOI: 10.1016/j.neurobiolaging.2006.11.019  0.84
2007 Gevaert T, Vriens J, Segal A, Everaerts W, Roskams T, Talavera K, Owsianik G, Liedtke W, Daelemans D, Dewachter I, Van Leuven F, Voets T, De Ridder D, Nilius B. Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding. The Journal of Clinical Investigation. 117: 3453-62. PMID 17948126 DOI: 10.1172/JCI31766  0.84
2007 Muhs A, Hickman DT, Pihlgren M, Chuard N, Giriens V, Meerschman C, van der Auwera I, van Leuven F, Sugawara M, Weingertner MC, Bechinger B, Greferath R, Kolonko N, Nagel-Steger L, Riesner D, et al. Liposomal vaccines with conformation-specific amyloid peptide antigens define immune response and efficacy in APP transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 104: 9810-5. PMID 17517595 DOI: 10.1073/pnas.0703137104  0.84
2007 Sennvik K, Boekhoorn K, Lasrado R, Terwel D, Verhaeghe S, Korr H, Schmitz C, Tomiyama T, Mori H, Krugers H, Joels M, Ramakers GJ, Lucassen PJ, Van Leuven F. Tau-4R suppresses proliferation and promotes neuronal differentiation in the hippocampus of tau knockin/knockout mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 2149-61. PMID 17341679 DOI: 10.1096/fj.06-7735com  0.84
2007 Cachard-Chastel M, Lezoualc'h F, Dewachter I, Deloménie C, Croes S, Devijver H, Langlois M, Van Leuven F, Sicsic S, Gardier AM. 5-HT4 receptor agonists increase sAPPalpha levels in the cortex and hippocampus of male C57BL/6j mice. British Journal of Pharmacology. 150: 883-92. PMID 17325649 DOI: 10.1038/sj.bjp.0707178  0.84
2007 Priller C, Dewachter I, Vassallo N, Paluch S, Pace C, Kretzschmar HA, Van Leuven F, Herms J. Mutant presenilin 1 alters synaptic transmission in cultured hippocampal neurons. The Journal of Biological Chemistry. 282: 1119-27. PMID 17088253 DOI: 10.1074/jbc.M605066200  0.84
2007 Thal DR, Larionov S, Abramowski D, Wiederhold KH, Van Dooren T, Yamaguchi H, Haass C, Van Leuven F, Staufenbiel M, Capetillo-Zarate E. Occurrence and co-localization of amyloid beta-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice. Neurobiology of Aging. 28: 1221-30. PMID 16815595 DOI: 10.1016/j.neurobiolaging.2006.05.029  0.84
2007 Van Leuven F. Alzheimer research forum discussion: Gain or loss of function - Time to shake up assumptions on γ-secretase in Alzheimer disease? Commentary Journal of Alzheimer's Disease. 11: 415.  0.84
2006 Muyllaert D, Terwel D, Borghgraef P, Devijver H, Dewachter I, Van Leuven F. Transgenic mouse models for Alzheimer's disease: the role of GSK-3B in combined amyloid and tau-pathology. Revue Neurologique. 162: 903-7. PMID 17028556  0.84
2006 Vandebroek T, Terwel D, Vanhelmont T, Gysemans M, Van Haesendonck C, Engelborghs Y, Winderickx J, Van Leuven F. Microtubule binding and clustering of human Tau-4R and Tau-P301L proteins isolated from yeast deficient in orthologues of glycogen synthase kinase-3beta or cdk5. The Journal of Biological Chemistry. 281: 25388-97. PMID 16818492 DOI: 10.1074/jbc.M602792200  0.84
2006 Boekhoorn K, Terwel D, Biemans B, Borghgraef P, Wiegert O, Ramakers GJ, de Vos K, Krugers H, Tomiyama T, Mori H, Joels M, van Leuven F, Lucassen PJ. Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 3514-23. PMID 16571759 DOI: 10.1523/JNEUROSCI.5425-05.2006  0.84
2006 Griffioen G, Duhamel H, Van Damme N, Pellens K, Zabrocki P, Pannecouque C, van Leuven F, Winderickx J, Wera S. A yeast-based model of alpha-synucleinopathy identifies compounds with therapeutic potential. Biochimica Et Biophysica Acta. 1762: 312-8. PMID 16413174 DOI: 10.1016/j.bbadis.2005.11.009  0.84
2006 Sastre M, Dewachter I, Rossner S, Bogdanovic N, Rosen E, Borghgraef P, Evert BO, Dumitrescu-Ozimek L, Thal DR, Landreth G, Walter J, Klockgether T, van Leuven F, Heneka MT. Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. Proceedings of the National Academy of Sciences of the United States of America. 103: 443-8. PMID 16407166 DOI: 10.1073/pnas.0503839103  0.84
2006 Van Dooren T, Muyllaert D, Borghgraef P, Cresens A, Devijver H, Van der Auwera I, Wera S, Dewachter I, Van Leuven F. Neuronal or glial expression of human apolipoprotein e4 affects parenchymal and vascular amyloid pathology differentially in different brain regions of double- and triple-transgenic mice. The American Journal of Pathology. 168: 245-60. PMID 16400027 DOI: 10.2353/ajpath.2006.050752  0.84
2005 Van der Auwera I, Wera S, Van Leuven F, Henderson ST. A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer's disease. Nutrition & Metabolism. 2: 28. PMID 16229744 DOI: 10.1186/1743-7075-2-28  0.84
2005 Heneka MT, Sastre M, Dumitrescu-Ozimek L, Dewachter I, Walter J, Klockgether T, Van Leuven F. Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice. Journal of Neuroinflammation. 2: 22. PMID 16212664 DOI: 10.1186/1742-2094-2-22  0.84
2005 Boldron C, Van der Auwera I, Deraeve C, Gornitzka H, Wera S, Pitié M, Van Leuven F, Meunier B. Preparation of cyclo-phen-type ligands: chelators of metal ions as potential therapeutic agents in the treatment of neurodegenerative diseases. Chembiochem : a European Journal of Chemical Biology. 6: 1976-80. PMID 16208731 DOI: 10.1002/cbic.200500220  0.84
2005 Zurbriggen R, Amacker M, Kammer AR, Westerfeld N, Borghgraef P, Van Leuven F, Van der Auwera I, Wera S. Virosome-based active immunization targets soluble amyloid species rather than plaques in a transgenic mouse model of Alzheimer's disease. Journal of Molecular Neuroscience : Mn. 27: 157-66. PMID 16186626 DOI: 10.1385/JMN:27:2:157  0.84
2005 Vandebroek T, Vanhelmont T, Terwel D, Borghgraef P, Lemaire K, Snauwaert J, Wera S, Van Leuven F, Winderickx J. Identification and isolation of a hyperphosphorylated, conformationally changed intermediate of human protein tau expressed in yeast. Biochemistry. 44: 11466-75. PMID 16114883 DOI: 10.1021/bi0506775  0.84
2005 Van Laer L, Pfister M, Thys S, Vrijens K, Mueller M, Umans L, Serneels L, Van Nassauw L, Kooy F, Smith RJ, Timmermans JP, Van Leuven F, Van Camp G. Mice lacking Dfna5 show a diverging number of cochlear fourth row outer hair cells. Neurobiology of Disease. 19: 386-99. PMID 16023581 DOI: 10.1016/j.nbd.2005.01.019  0.84
2005 Heneka MT, Sastre M, Dumitrescu-Ozimek L, Hanke A, Dewachter I, Kuiperi C, O'Banion K, Klockgether T, Van Leuven F, Landreth GE. Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. Brain : a Journal of Neurology. 128: 1442-53. PMID 15817521 DOI: 10.1093/brain/awh452  0.84
2005 Zabrocki P, Pellens K, Vanhelmont T, Vandebroek T, Griffioen G, Wera S, Van Leuven F, Winderickx J. Characterization of alpha-synuclein aggregation and synergistic toxicity with protein tau in yeast. The Febs Journal. 272: 1386-400. PMID 15752356 DOI: 10.1111/j.1742-4658.2005.04571.x  0.84
2005 Vanhoutte G, Dewachter I, Borghgraef P, Van Leuven F, Van der Linden A. Noninvasive in vivo MRI detection of neuritic plaques associated with iron in APP[V717I] transgenic mice, a model for Alzheimer's disease. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 53: 607-13. PMID 15723413 DOI: 10.1002/mrm.20385  0.84
2005 van Dooren T, Dewachter I, Borghgraef P, van Leuven F. Transgenic mouse models for APP processing and Alzheimer's disease: early and late defects. Sub-Cellular Biochemistry. 38: 45-63. PMID 15709472  0.84
2005 Terwel D, Lasrado R, Snauwaert J, Vandeweert E, Van Haesendonck C, Borghgraef P, Van Leuven F. Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice. The Journal of Biological Chemistry. 280: 3963-73. PMID 15509565 DOI: 10.1074/jbc.M409876200  0.84
2005 He H, McCartney DJ, Wei Q, Esadeg S, Zhang J, Foster RA, Hayes MA, Tayade C, Van Leuven F, Croy BA. Characterization of a murine alpha 2 macroglobulin gene expressed in reproductive and cardiovascular tissue. Biology of Reproduction. 72: 266-75. PMID 15355875 DOI: 10.1095/biolreprod.104.029835  0.84
2004 Boom A, Pochet R, Authelet M, Pradier L, Borghgraef P, Van Leuven F, Heizmann CW, Brion JP. Astrocytic calcium/zinc binding protein S100A6 over expression in Alzheimer's disease and in PS1/APP transgenic mice models. Biochimica Et Biophysica Acta. 1742: 161-8. PMID 15590066 DOI: 10.1016/j.bbamcr.2004.09.011  0.84
2004 Willem M, Dewachter I, Smyth N, Van Dooren T, Borghgraef P, Haass C, Van Leuven F. beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice. The American Journal of Pathology. 165: 1621-31. PMID 15509532  0.84
2004 Etcheberrigaray R, Tan M, Dewachter I, Kuipéri C, Van der Auwera I, Wera S, Qiao L, Bank B, Nelson TJ, Kozikowski AP, Van Leuven F, Alkon DL. Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 101: 11141-6. PMID 15263077 DOI: 10.1073/pnas.0403921101  0.84
2004 Postina R, Schroeder A, Dewachter I, Bohl J, Schmitt U, Kojro E, Prinzen C, Endres K, Hiemke C, Blessing M, Flamez P, Dequenne A, Godaux E, van Leuven F, Fahrenholz F. A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. The Journal of Clinical Investigation. 113: 1456-64. PMID 15146243 DOI: 10.1172/JCI20864  0.84
2003 Sastre M, Dewachter I, Landreth GE, Willson TM, Klockgether T, van Leuven F, Heneka MT. Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 9796-804. PMID 14586007  0.84
2003 Esadeg S, He H, Pijnenborg R, Van Leuven F, Croy BA. Alpha-2 macroglobulin controls trophoblast positioning in mouse implantation sites. Placenta. 24: 912-21. PMID 14580373 DOI: 10.1016/S0143-4004(03)00148-6  0.84
2003 Ris L, Dewachter I, Reversé D, Godaux E, Van Leuven F. Capacitative calcium entry induces hippocampal long term potentiation in the absence of presenilin-1. The Journal of Biological Chemistry. 278: 44393-9. PMID 12902342 DOI: 10.1074/jbc.M300971200  0.84
2003 Pocathikorn A, Granath B, Thiry E, Van Leuven F, Taylor R, Mamotte C. Influence of exonic polymorphisms in the gene for LDL receptor-related protein (LRP) on risk of coronary artery disease. Atherosclerosis. 168: 115-21. PMID 12732394 DOI: 10.1016/S0021-9150(03)00087-X  0.84
2003 Gilissen C, de Groot TJ, Bronfman F, van Leuven F, Verbruggen AM, Bormans GM. Evaluation of 18F-FA-4 and 11C-pipzA-4 as radioligands for the in vivo evaluation of the high-affinity choline uptake system. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 44: 269-75. PMID 12571220  0.84
2003 Frenkel D, Dewachter I, Van Leuven F, Solomon B. Reduction of beta-amyloid plaques in brain of transgenic mouse model of Alzheimer's disease by EFRH-phage immunization. Vaccine. 21: 1060-5. PMID 12559780 DOI: 10.1016/S0264-410X(02)00609-6  0.84
2003 Herms J, Schneider I, Dewachter I, Caluwaerts N, Kretzschmar H, Van Leuven F. Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein. The Journal of Biological Chemistry. 278: 2484-9. PMID 12431992 DOI: 10.1074/jbc.M206769200  0.84
2003 Van Dorpe J, Spittaels K, Van den Haute CV, Dewachter I, Moechars D, Geerts H, Van Leuven F. Neuropathobiology in transgenic mice. The case of Alzheimer's disease. Methods in Molecular Biology (Clifton, N.J.). 209: 333-61. PMID 12357960  0.84
2002 Dewachter I, Van Leuven F. Secretases as targets for the treatment of Alzheimer's disease: the prospects. The Lancet. Neurology. 1: 409-16. PMID 12849363 DOI: 10.1016/S1474-4422(02)00188-6  0.84
2002 Simsek S, van Leuven F, Bronsveld W, Ooms GH, Groeneveld AB, de Graaff CS. Unusual association of Hodgkin's disease and sarcoidosis. The Netherlands Journal of Medicine. 60: 438-40. PMID 12685492  0.84
2002 Terwel D, Dewachter I, Van Leuven F. Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease. Neuromolecular Medicine. 2: 151-65. PMID 12428809 DOI: 10.1385/NMM:2:2:151  0.84
2002 Künzi V, Glatzel M, Nakano MY, Greber UF, Van Leuven F, Aguzzi A. Unhampered prion neuroinvasion despite impaired fast axonal transport in transgenic mice overexpressing four-repeat tau. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 7471-7. PMID 12196569  0.84
2002 Waghabi MC, Coutinho CM, Soeiro MN, Pereira MC, Feige JJ, Keramidas M, Cosson A, Minoprio P, Van Leuven F, Araújo-Jorge TC. Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin. Infection and Immunity. 70: 5115-23. PMID 12183561 DOI: 10.1128/IAI.70.9.5115-5123.2002  0.84
2002 Spittaels K, Van den Haute C, Van Dorpe J, Terwel D, Vandezande K, Lasrado R, Bruynseels K, Irizarry M, Verhoye M, Van Lint J, Vandenheede JR, Ashton D, Mercken M, Loos R, Hyman B, ... ... Van Leuven F, et al. Neonatal neuronal overexpression of glycogen synthase kinase-3 beta reduces brain size in transgenic mice. Neuroscience. 113: 797-808. PMID 12182887 DOI: 10.1016/S0306-4522(02)00236-1  0.84
2002 Smeijers L, Willems S, Lauwers A, Thiry E, van Leuven F, Roebroek AJ. Functional expression of murine LRP1 requires correction of Lrp1 cDNA sequences. Biochimica Et Biophysica Acta. 1577: 155-8. PMID 12151109 DOI: 10.1016/S0167-4781(02)00419-0  0.84
2002 Tilleman K, Van den Haute C, Geerts H, van Leuven F, Esmans EL, Moens L. Proteomics analysis of the neurodegeneration in the brain of tau transgenic mice. Proteomics. 2: 656-65. PMID 12112845 DOI: 10.1002/1615-9861(200206)2:6<656::AID-PROT656>3.0.CO;2-Z  0.84
2002 Gourine AV, Gourine VN, Tesfaigzi Y, Caluwaerts N, Van Leuven F, Kluger MJ. Role of alpha(2)-macroglobulin in fever and cytokine responses induced by lipopolysaccharide in mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 283: R218-26. PMID 12069948 DOI: 10.1152/ajpregu.00746.2001  0.84
2002 Van Dorpe J, Dal Cin P, Weremowicz S, Van Leuven F, de Wever I, Van den Berghe H, Fletcher CD, Sciot R. Translocation of the HMGI-C ( HMGA2) gene in a benign mesenchymoma (chondrolipoangioma). Virchows Archiv : An International Journal of Pathology. 440: 485-90. PMID 12021922 DOI: 10.1007/s00428-001-0547-z  0.84
2002 Dewachter I, Reversé D, Caluwaerts N, Ris L, Kuipéri C, Van den Haute C, Spittaels K, Umans L, Serneels L, Thiry E, Moechars D, Mercken M, Godaux E, Van Leuven F. Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 3445-53. PMID 11978821  0.84
2002 Permanne B, Adessi C, Saborio GP, Fraga S, Frossard MJ, Van Dorpe J, Dewachter I, Banks WA, Van Leuven F, Soto C. Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a beta-sheet breaker peptide. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 860-2. PMID 11967228 DOI: 10.1096/fj.01-0841fje  0.84
2002 Hochepied T, Van Leuven F, Libert C. Mice lacking alpha(2)-macroglobulin show an increased host defense against Gram-negative bacterial sepsis, but are more susceptible to endotoxic shock. European Cytokine Network. 13: 86-91. PMID 11956025  0.84
2002 Nuydens R, Van Den Kieboom G, Nolten C, Verhulst C, Van Osta P, Spittaels K, Van den Haute C, De Feyter E, Geerts H, Van Leuven F. Coexpression of GSK-3beta corrects phenotypic aberrations of dorsal root ganglion cells, cultured from adult transgenic mice overexpressing human protein tau. Neurobiology of Disease. 9: 38-48. PMID 11848683 DOI: 10.1006/nbdi.2001.0454  0.84
2002 Tilleman K, Stevens I, Spittaels K, Haute CV, Clerens S, Van Den Bergh G, Geerts H, Van Leuven F, Vandesande F, Moens L. Differential expression of brain proteins in glycogen synthase kinase-3 transgenic mice: a proteomics point of view. Proteomics. 2: 94-104. PMID 11788996 DOI: 10.1002/1615-9861(200201)2:1<94::AID-PROT94>3.0.CO;2-W  0.84
2001 Descamps OS, Gilbeau JP, Leysen X, Van Leuven F, Heller FR. Impact of genetic defects on atherosclerosis in patients suspected of familial hypercholesterolaemia. European Journal of Clinical Investigation. 31: 958-65. PMID 11737238 DOI: 10.1046/j.1365-2362.2001.00915.x  0.84
2001 Correia Soeiro MN, Paiva MM, Waghabi M, Meirelles MN, Lorent K, Araújo-Jorge TC, Van Leuven F. Differential expression of mRNA coding for the alpha-2-macroglobulin family and the LRP receptor system in C57BL/6J and C3H/HeJ male mice. Cell Structure and Function. 26: 161-7. PMID 11565808 DOI: 10.1247/csf.26.161  0.84
2001 Descamps OS, Leysen X, Van Leuven F, Heller FR. The use of Achilles tendon ultrasonography for the diagnosis of familial hypercholesterolemia. Atherosclerosis. 157: 514-8. PMID 11472754 DOI: 10.1016/S0021-9150(01)00533-0  0.84
2001 Dewachter I, Moechars D, van Dorpe J, Tesseur I, Van den Haute C, Spittaels K, Van Leuven F. Modelling Alzheimer's disease in multiple transgenic mice. Biochemical Society Symposium. 203-10. PMID 11447836  0.84
2001 Schneider I, Reverse D, Dewachter I, Ris L, Caluwaerts N, Kuiperi C, Gilis M, Geerts H, Kretzschmar H, Godaux E, Moechars D, Van Leuven F, Herms J. Mutant presenilins disturb neuronal calcium homeostasis in the brain of transgenic mice, decreasing the threshold for excitotoxicity and facilitating long-term potentiation. The Journal of Biological Chemistry. 276: 11539-44. PMID 11278803 DOI: 10.1074/jbc.M010977200  0.84
2001 Van Leuven F, Thiry E, Lambrechts M, Stas L, Boon T, Bruynseels K, Muls E, Descamps O. Sequencing of the coding exons of the LRP1 and LDLR genes on individual DNA samples reveals novel mutations in both genes. Atherosclerosis. 154: 567-77. PMID 11257257 DOI: 10.1016/S0021-9150(00)00657-2  0.84
2001 Van den Haute C, Spittaels K, Van Dorpe J, Lasrado R, Vandezande K, Laenen I, Geerts H, Van Leuven F. Coexpression of human cdk5 and its activator p35 with human protein tau in neurons in brain of triple transgenic mice. Neurobiology of Disease. 8: 32-44. PMID 11162238 DOI: 10.1006/nbdi.2000.0333  0.84
2000 Barre A, Peumans WJ, Menu-Bouaouiche L, Van Damme EJ, May GD, Herrera AF, Van Leuven F, Rougé P. Purification and structural analysis of an abundant thaumatin-like protein from ripe banana fruit. Planta. 211: 791-9. PMID 11144263  0.84
2000 Hochepied T, Ameloot P, Brouckaert P, Van Leuven F, Libert C. Differential response of a(2)-macroglobulin-deficient mice in models of lethal TNF-induced inflammation. European Cytokine Network. 11: 597-601. PMID 11125302  0.84
2000 Tesseur I, Van Dorpe J, Bruynseels K, Bronfman F, Sciot R, Van Lommel A, Van Leuven F. Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord. The American Journal of Pathology. 157: 1495-510. PMID 11073810 DOI: 10.1016/S0002-9440(10)64788-8  0.84
2000 Dewachter I, van Dorpe J, Spittaels K, Tesseur I, Van Den Haute C, Moechars D, Van Leuven F. Modeling Alzheimer's disease in transgenic mice: effect of age and of presenilin1 on amyloid biochemistry and pathology in APP/London mice. Experimental Gerontology. 35: 831-41. PMID 11053674 DOI: 10.1016/S0531-5565(00)00149-2  0.84
2000 Soeiro Mde N, Paiva MM, Waghabi MC, Meirelles Mde N, Lorent K, Henriques-Pons A, Coutinho CM, Van Leuven F, Araújo-Jorge TC. Trypanosoma cruzi: acute infection affects expression of alpha-2-macroglobulin and A2MR/LRP receptor differently in C3H and C57BL/6 mice. Experimental Parasitology. 96: 97-107. PMID 11052868 DOI: 10.1006/expr.2000.4555  0.52
2000 Peumans WJ, Zhang W, Barre A, Houlès Astoul C, Balint-Kurti PJ, Rovira P, Rougé P, May GD, Van Leuven F, Truffa-Bachi P, Van Damme EJ. Fruit-specific lectins from banana and plantain. Planta. 211: 546-54. PMID 11030554  0.84
2000 Van Dorpe J, Smeijers L, Dewachter I, Nuyens D, Spittaels K, Van Den Haute C, Mercken M, Moechars D, Laenen I, Kuiperi C, Bruynseels K, Tesseur I, Loos R, Vanderstichele H, Checler F, ... ... Van Leuven F, et al. Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons. The American Journal of Pathology. 157: 1283-98. PMID 11021833 DOI: 10.1016/S0002-9440(10)64644-5  0.84
2000 Spittaels K, Van den Haute C, Van Dorpe J, Geerts H, Mercken M, Bruynseels K, Lasrado R, Vandezande K, Laenen I, Boon T, Van Lint J, Vandenheede J, Moechars D, Loos R, Van Leuven F. Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice. The Journal of Biological Chemistry. 275: 41340-9. PMID 11007782 DOI: 10.1074/jbc.M006219200  0.84
2000 Dewachter I, Van Dorpe J, Smeijers L, Gilis M, Kuipéri C, Laenen I, Caluwaerts N, Moechars D, Checler F, Vanderstichele H, Van Leuven F. Aging increased amyloid peptide and caused amyloid plaques in brain of old APP/V717I transgenic mice by a different mechanism than mutant presenilin1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 6452-8. PMID 10964951  0.84
2000 Bronfman FC, Moechars D, Van Leuven F. Acetylcholinesterase-positive fiber deafferentation and cell shrinkage in the septohippocampal pathway of aged amyloid precursor protein london mutant transgenic mice. Neurobiology of Disease. 7: 152-68. PMID 10860782 DOI: 10.1006/nbdi.2000.0283  0.84
2000 Masliah E, Alford M, Mallory M, Rockenstein E, Moechars D, Van Leuven F. Abnormal glutamate transport function in mutant amyloid precursor protein transgenic mice. Experimental Neurology. 163: 381-7. PMID 10833311 DOI: 10.1006/exnr.2000.7386  0.84
2000 Bronfman FC, Tesseur I, Hofker MH, Havekens LM, Van Leuven F. No evidence for cholinergic problems in apolipoprotein E knockout and apolipoprotein E4 transgenic mice. Neuroscience. 97: 411-8. PMID 10828523 DOI: 10.1016/S0306-4522(00)00016-6  0.84
2000 Van Damme EJ, Hao Q, Charels D, Barre A, Rougé P, Van Leuven F, Peumans WJ. Characterization and molecular cloning of two different type 2 ribosome-inactivating proteins from the monocotyledonous plant Polygonatum multiflorum. European Journal of Biochemistry / Febs. 267: 2746-59. PMID 10785398 DOI: 10.1046/j.1432-1327.2000.01295.x  0.84
2000 van Leuven F. Single and multiple transgenic mice as models for Alzheimer's disease. Progress in Neurobiology. 61: 305-12. PMID 10727777 DOI: 10.1016/S0301-0082(99)00055-6  0.84
2000 Tesseur I, Van Dorpe J, Spittaels K, Van den Haute C, Moechars D, Van Leuven F. Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice. The American Journal of Pathology. 156: 951-64. PMID 10702411 DOI: 10.1016/S0002-9440(10)64963-2  0.84
2000 Van Damme EJ, Hao Q, Barre A, Rougé P, Van Leuven F, Peumans WJ. Major protein of resting rhizomes of Calystegia sepium (hedge bindweed) closely resembles plant RNases but has no enzymatic activity. Plant Physiology. 122: 433-46. PMID 10677436  0.84
2000 Peumans WJ, Barre A, Derycke V, Rougé P, Zhang W, May GD, Delcour JA, Van Leuven F, Van Damme EJ. Purification, characterization and structural analysis of an abundant beta-1,3-glucanase from banana fruit. European Journal of Biochemistry / Febs. 267: 1188-95. PMID 10672030 DOI: 10.1046/j.1432-1327.2000.01117.x  0.84
2000 Kumar-Singh S, Dewachter I, Moechars D, Lübke U, De Jonghe C, Ceuterick C, Checler F, Naidu A, Cordell B, Cras P, Van Broeckhoven C, Van Leuven F. Behavioral disturbances without amyloid deposits in mice overexpressing human amyloid precursor protein with Flemish (A692G) or Dutch (E693Q) mutation. Neurobiology of Disease. 7: 9-22. PMID 10671319 DOI: 10.1006/nbdi.1999.0272  0.84
2000 Araújo-Jorge TC, Waghabi MC, Coutinho CMLM, Soeiro MDNC, Minoprio P, Feige JJ, Van Leuven F. MC7 - Protective role of the physiological alpha-macroglobulin protease inhibitors in Chagas' disease Memorias Do Instituto Oswaldo Cruz. 95: 27-28.  0.84
1999 Umans L, Serneels L, Lorent K, Dewachter I, Tesseur I, Moechars D, Van Leuven F. Lipoprotein receptor-related protein in brain and in cultured neurons of mice deficient in receptor-associated protein and transgenic for apolipoprotein E4 or amyloid precursor protein. Neuroscience. 94: 315-21. PMID 10613521 DOI: 10.1016/S0306-4522(99)00242-0  0.84
1999 Spittaels K, Van den Haute C, Van Dorpe J, Bruynseels K, Vandezande K, Laenen I, Geerts H, Mercken M, Sciot R, Van Lommel A, Loos R, Van Leuven F. Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein. The American Journal of Pathology. 155: 2153-65. PMID 10595944 DOI: 10.1016/S0002-9440(10)65533-2  0.84
1999 Umans L, Overbergh L, Serneels L, Tesseur I, Van Leuven F. Analysis of expression of genes involved in apolipoprotein E-based lipoprotein metabolism in pregnant mice deficient in the receptor-associated protein, the low density lipoprotein receptor, or apolipoprotein E. Biology of Reproduction. 61: 1216-25. PMID 10529267 DOI: 10.1095/biolreprod61.5.1216  0.84
1999 Herreman A, Hartmann D, Annaert W, Saftig P, Craessaerts K, Serneels L, Umans L, Schrijvers V, Checler F, Vanderstichele H, Baekelandt V, Dressel R, Cupers P, Huylebroeck D, Zwijsen A, ... Van Leuven F, et al. Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proceedings of the National Academy of Sciences of the United States of America. 96: 11872-7. PMID 10518543 DOI: 10.1073/pnas.96.21.11872  0.84
1999 Lévesque L, Annaert W, Craessaerts K, Mathews PM, Seeger M, Nixon RA, Van Leuven F, Gandy S, Westaway D, St George-Hyslop P, De Strooper B, Fraser PE. Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1. Molecular Medicine (Cambridge, Mass.). 5: 542-54. PMID 10501657  0.84
1999 Umans L, Serneels L, Overbergh L, Stas L, Van Leuven F. alpha2-macroglobulin- and murinoglobulin-1- deficient mice. A mouse model for acute pancreatitis. The American Journal of Pathology. 155: 983-93. PMID 10487856  0.84
1999 Wavrant-DeVrièze F, Lambert JC, Stas L, Crook R, Cottel D, Pasquier F, Frigard B, Lambrechts M, Thiry E, Amouyel P, Tur JP, Chartier-Harlin MC, Hardy J, Van Leuven F. Association between coding variability in the LRP gene and the risk of late-onset Alzheimer's disease. Human Genetics. 104: 432-4. PMID 10394937 DOI: 10.1007/s004390050980  0.84
1999 Moechars D, Lorent K, Van Leuven F. Premature death in transgenic mice that overexpress a mutant amyloid precursor protein is preceded by severe neurodegeneration and apoptosis. Neuroscience. 91: 819-30. PMID 10391465 DOI: 10.1016/S0306-4522(98)00599-5  0.84
1999 Machuka JS, Okeola OG, Van Damme Els JM, Chrispeels MJ, Van Leuven F, Peumans WJ. Isolation and partial characterisation of galactose-specific lectins from African yam beans, Sphenostyles stenocarpa Harms. Phytochemistry. 51: 721-8. PMID 10389271 DOI: 10.1016/S0031-9422(99)00136-3  0.84
1999 Bonaventure P, Umans L, Bakker MH, Cras P, Langlois X, Luyten WH, Megens AA, Serneels L, Van Leuven F, Leysen JE. Humanization of mouse 5-hydroxytryptamine1B receptor gene by homologous recombination: in vitro and in vivo characterization. Molecular Pharmacology. 56: 54-67. PMID 10385684  0.84
1999 Rogaeva EA, Premkumar S, Grubber J, Serneels L, Scott WK, Kawarai T, Song Y, Hill DL, Abou-Donia SM, Martin ER, Vance JJ, Yu G, Orlacchio A, Pei Y, Nishimura M, ... ... Van Leuven F, et al. An alpha-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease. Nature Genetics. 22: 19-22. PMID 10319855 DOI: 10.1038/8729  0.84
1999 Wright LM, Van Damme EJ, Barre A, Allen AK, Van Leuven F, Reynolds CD, Rouge P, Peumans WJ. Isolation, characterization, molecular cloning and molecular modelling of two lectins of different specificities from bluebell (Scilla campanulata) bulbs. The Biochemical Journal. 340: 299-308. PMID 10229686 DOI: 10.1042/0264-6021:3400299  0.84
1999 Van Damme EJ, Charels D, Roy S, Tierens K, Barre A, Martins JC, Rougé P, Van Leuven F, Does M, Peumans WJ. A gene encoding a hevein-like protein from elderberry fruits is homologous to PR-4 and class V chitinase genes. Plant Physiology. 119: 1547-56. PMID 10198114  0.84
1999 Coutinho CM, van Leuven F, Araújo-Jorge TC. Detection of alpha-macroglobulin in the heart of mice infected with Trypanosoma cruzi. Parasitology Research. 85: 249-55. PMID 10099003 DOI: 10.1007/s004360050543  0.84
1999 Moechars D, Dewachter I, Lorent K, Reversé D, Baekelandt V, Naidu A, Tesseur I, Spittaels K, Haute CV, Checler F, Godaux E, Cordell B, Van Leuven F. Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. The Journal of Biological Chemistry. 274: 6483-92. PMID 10037741 DOI: 10.1074/jbc.274.10.6483  0.84
1999 Moechars D, Van Leuven F. Transgenic mice as model for Alzheimer's disease | Genetica transgene muizen als model voor de ziekte van Alzheimer Tijdschrift Voor Geneeskunde. 55: 212-218. DOI: 10.2143/TVG.55.3.1000347  0.84
1999 Annaert W, Van Leuven F, De Strooper B. A cell biological study the Alzheimer's disease | Celbiologische studie van de ziekte van Alzheimer Tijdschrift Voor Geneeskunde. 55: 49-54. DOI: 10.2143/TVG.55.1.1000312  0.84
1999 Baekelandt V, Moechars D, Laenen I, Lorent K, Van Leuven F. Disturbance of the glutamatergic system in mice transgenic for the amyloid precursor protein Alzheimer's Reports. 2: 359-368.  0.84
1998 Van Leuven F, Torrekens S, Moechars D, Hilliker C, Buellens M, Bollen M, Delabie J. Molecular cloning of a gene on chromosome 19q12 coding for a novel intracellular protein: analysis of expression in human and mouse tissues and in human tumor cells, particularly Reed-Sternberg cells in Hodgkin disease. Genomics. 54: 511-20. PMID 9878255 DOI: 10.1006/geno.1998.5609  0.84
1998 Moechars D, Gilis M, Kuipéri C, Laenen I, Van Leuven F. Aggressive behaviour in transgenic mice expressing APP is alleviated by serotonergic drugs. Neuroreport. 9: 3561-4. PMID 9858360  0.84
1998 Roebroek AJ, Umans L, Pauli IG, Robertson EJ, van Leuven F, Van de Ven WJ, Constam DB. Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin. Development (Cambridge, England). 125: 4863-76. PMID 9811571  0.84
1998 Coutinho CM, Cavalcanti G, DaMatta RA, Van Leuven F, Araújo-Jorge TC. Alpha-2-macroglobulin receptor is differently expressed in peritoneal macrophages from C3H and C57/B16 mice and up-regulated during Trypanosoma cruzi infection. Tissue & Cell. 30: 407-15. PMID 9787474 DOI: 10.1016/S0040-8166(98)80055-4  0.84
1998 Van Leuven F, Thiry E, Stas L, Nelissen B. Analysis of the human LRPAP1 gene coding for the lipoprotein receptor-associated protein: identification of 22 polymorphisms and one mutation. Genomics. 52: 145-51. PMID 9782079 DOI: 10.1006/geno.1998.5413  0.84
1998 Van Leuven F, Stas L, Thiry E, Nelissen B, Miyake Y. Strategy to sequence the 89 exons of the human LRP1 gene coding for the lipoprotein receptor related protein: identification of one expressed mutation among 48 polymorphisms. Genomics. 52: 138-44. PMID 9782078 DOI: 10.1006/geno.1998.5408  0.84
1998 Moechars D, Lorent K, Dewachter I, Baekelandt V, De Strooper B, Van Leuven F. Transgenic mice expressing an alpha-secretion mutant of the amyloid precursor protein in the brain develop a progressive CNS disorder. Behavioural Brain Research. 95: 55-64. PMID 9754877 DOI: 10.1016/S0166-4328(97)00210-6  0.84
1998 Bleukx W, Brijs K, Torrekens S, Van Leuven F, Delcour JA. Specificity of a wheat gluten aspartic proteinase. Biochimica Et Biophysica Acta. 1387: 317-24. PMID 9748641 DOI: 10.1016/S0167-4838(98)00146-0  0.84
1998 Michiels L, Van Leuven F, van den Oord JJ, De Wolf-Peeters C, Delabie J. Representational difference analysis using minute quantities of DNA. Nucleic Acids Research. 26: 3608-10. PMID 9671826 DOI: 10.1093/nar/26.15.3608  0.84
1998 Peumans WJ, Roy S, Barre A, Rouge P, van Leuven F, van Damme EJ. Elderberry (Sambucus nigra) contains truncated Neu5Ac(alpha-2,6)Gal/GalNAc-binding type 2 ribosome-inactivating proteins. Febs Letters. 425: 35-9. PMID 9541002 DOI: 10.1016/S0014-5793(98)00193-8  0.84
1998 De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, Von Figura K, Van Leuven F. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature. 391: 387-90. PMID 9450754 DOI: 10.1038/34910  0.84
1998 Vergauwen R, Van Leuven F, Van Laere A. Purification and characterization of strongly chitin-binding chitinases from salicylic acid-treated leek (Allium porrum) Physiologia Plantarum. 104: 175-182. DOI: 10.1034/j.1399-3054.1998.1040205.x  0.84
1998 Bleukx W, Torrekens S, Van Leuven F, Delcour JA. Purification, properties and N-terminal amino acid sequence of a wheat gluten aspartic proteinase Journal of Cereal Science. 28: 223-232.  0.84
1997 Van Damme EJ, Roy S, Barre A, Rougé P, Van Leuven F, Peumans WJ. The major elderberry (Sambucus nigra) fruit protein is a lectin derived from a truncated type 2 ribosome-inactivating protein. The Plant Journal : For Cell and Molecular Biology. 12: 1251-60. PMID 9450339 DOI: 10.1046/j.1365-313x.1997.12061251.x  0.84
1997 Cleemput G, Van Laere K, Hessing M, Van Leuven F, Torrekens S, Delcour JA. Identification and characterization of a novel arabinoxylanase from wheat flour. Plant Physiology. 115: 1619-27. PMID 9414565  0.84
1997 Smeets K, Van Damme EJ, Van Leuven F, Peumans WJ. Isolation, characterization and molecular cloning of a leaf-specific lectin from ramsons (Allium ursinum L.). Plant Molecular Biology. 35: 531-5. PMID 9349275 DOI: 10.1023/A:1005887016694  0.84
1997 Van Damme EJ, Van Leuven F, Peumans WJ. Isolation, characterization and molecular cloning of the bark lectins from Maackia amurensis. Glycoconjugate Journal. 14: 449-56. PMID 9249142 DOI: 10.1023/A:1018595300863  0.84
1997 Van Damme EJ, Barre A, Barbieri L, Valbonesi P, Rouge P, Van Leuven F, Stirpe F, Peumans WJ. Type 1 ribosome-inactivating proteins are the most abundant proteins in iris (Iris hollandica var. Professor Blaauw) bulbs: characterization and molecular cloning. The Biochemical Journal. 324: 963-70. PMID 9210423  0.84
1997 Van Damme EJ, Roy S, Barre A, Citores L, Mostafapous K, Rougé P, Van Leuven F, Girbés T, Goldstein IJ, Peumans WJ. Elderberry (Sambucus nigra) bark contains two structurally different Neu5Ac(alpha2,6)Gal/GalNAc-binding type 2 ribosome-inactivating proteins. European Journal of Biochemistry / Febs. 245: 648-55. PMID 9183001  0.84
1997 Smeets K, Van Damme EJ, Van Leuven F, Peumans WJ. Isolation and characterization of lectins and lectin-alliinase complexes from bulbs of garlic (Allium sativum) and ramsons (Allium ursinum). Glycoconjugate Journal. 14: 331-43. PMID 9147057 DOI: 10.1023/A:1018570628180  0.84
1997 Peumans WJ, Smeets K, Van Nerum K, Van Leuven F, Van Damme EJ. Lectin and alliinase are the predominant proteins in nectar from leek (Allium porrum L.) flowers. Planta. 201: 298-302. PMID 9129337 DOI: 10.1007/s004250050070  0.84
1997 Peumans WJ, Winter HC, Bemer V, Van Leuven F, Goldstein IJ, Truffa-Bachi P, Van Damme EJ. Isolation of a novel plant lectin with an unusual specificity from Calystegia sepium. Glycoconjugate Journal. 14: 259-65. PMID 9111143 DOI: 10.1023/A:1018502107707  0.84
1997 Van Damme EJ, Barre A, Rougé P, Van Leuven F, Peumans WJ. Isolation and molecular cloning of a novel type 2 ribosome-inactivating protein with an inactive B chain from elderberry (Sambucus nigra) bark. The Journal of Biological Chemistry. 272: 8353-60. PMID 9079659 DOI: 10.1074/jbc.272.13.8353  0.84
1997 Coutinho CM, Cavalcanti GH, van Leuven F, Araújo-Jorge TC. Alpha-2-macroglobulin binds to the surface of Trypanosoma cruzi. Parasitology Research. 83: 144-50. PMID 9039696 DOI: 10.1007/s004360050224  0.84
1997 Smeets K, Van Damme EJ, Verhaert P, Barre A, Rougé P, Van Leuven F, Peumans WJ. Isolation, characterization and molecular cloning of the mannose-binding lectins from leaves and roots of garlic (Allium sativum L.). Plant Molecular Biology. 33: 223-34. PMID 9037141 DOI: 10.1023/A:1005717020021  0.84
1997 De Strooper B, Beullens M, Contreras B, Levesque L, Craessaerts K, Cordell B, Moechars D, Bollen M, Fraser P, George-Hyslop PS, Van Leuven F. Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins. The Journal of Biological Chemistry. 272: 3590-8. PMID 9013610 DOI: 10.1074/jbc.272.6.3590  0.84
1996 Medrano NM, Luz MR, Cabello PH, Tapia GT, Van Leuven F, Araújo-Jorge TC. Acute Chagas' disease: plasma levels of alpha-2-macroglobulin and C-reactive protein in children under 13 years in a high endemic area of Bolivia. Journal of Tropical Pediatrics. 42: 68-74. PMID 8984217  0.84
1996 Baumgart E, Vanhooren JC, Fransen M, Van Leuven F, Fahimi HD, Van Veldhoven PP, Mannaerts GP. Molecular cloning and further characterization of rat peroxisomal trihydroxycoprostanoyl-CoA oxidase. The Biochemical Journal. 320: 115-21. PMID 8947475  0.84
1996 De Strooper B, Wu RR, Jaspers M, Van der Schueren B, Vekemans S, Carmeliet G, Van Leuven F, Van Den Oord J, Cassiman JJ. A 68-kD antigen, which is probably an N-terminal fragment of the VLA-5 alpha 5-subunit, is specific for differentiating keratinocytes. Dermatology (Basel, Switzerland). 193: 212-20. PMID 8944343  0.84
1996 Berghman LR, Lescroart O, Roelants I, Ollevier F, Kühn ER, Verhaert PD, De Loof A, van Leuven F, Vandesande F. One-step immunoaffinity purification and partial characterization of hypophyseal growth hormone from the African catfish, Clarias gariepinus (Burchell). Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 113: 773-80. PMID 8925443 DOI: 10.1016/0305-0491(95)02098-5  0.84
1996 Saftig P, Peters C, von Figura K, Craessaerts K, Van Leuven F, De Strooper B. Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D. The Journal of Biological Chemistry. 271: 27241-4. PMID 8910296 DOI: 10.1074/jbc.271.44.27241  0.84
1996 Tienari PJ, De Strooper B, Ikonen E, Simons M, Weidemann A, Czech C, Hartmann T, Ida N, Multhaup G, Masters CL, Van Leuven F, Beyreuther K, Dotti CG. The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein. The Embo Journal. 15: 5218-29. PMID 8895567  0.84
1996 De Bolle MF, Osborn RW, Goderis IJ, Noe L, Acland D, Hart CA, Torrekens S, Van Leuven F, Broekaert WF. Antimicrobial peptides from Mirabilis jalapa and Amaranthus caudatus: expression, processing, localization and biological activity in transgenic tobacco. Plant Molecular Biology. 31: 993-1008. PMID 8843942  0.84
1996 Van Leuven F, Stas L, Hilliker C, Miyake Y, Bilinski P, Gossler A. Molecular cloning and characterization of the human interleukin-11 receptor alpha-chain gene, IL11RA, located on chromosome 9p13. Genomics. 31: 65-70. PMID 8808281 DOI: 10.1006/geno.1996.0010  0.84
1996 Webb DJ, Wen J, Lysiak JJ, Umans L, Van Leuven F, Gonias SL. Murine alpha-macroglobulins demonstrate divergent activities as neutralizers of transforming growth factor-beta and as inducers of nitric oxide synthesis. A possible mechanism for the endotoxin insensitivity of the alpha2-macroglobulin gene knock-out mouse. The Journal of Biological Chemistry. 271: 24982-8. PMID 8798779 DOI: 10.1074/jbc.271.40.24982  0.84
1996 Van Damme EJ, Barre A, Rougé P, Van Leuven F, Balzarini J, Peumans WJ. Molecular cloning of the lectin and a lectin-related protein from common Solomon's seal (Polygonatum multiflorum). Plant Molecular Biology. 31: 657-72. PMID 8790297  0.84
1996 Vanhooren JC, Fransen M, de Béthune B, Baumgart E, Baes M, Torrekens S, Van Leuven F, Mannaerts GP, Van Veldhoven PP. Rat pristanoyl-CoA oxidase. cDNA cloning and recognition of its C-terminal (SQL) by the peroxisomal-targeting signal 1 receptor. European Journal of Biochemistry / Febs. 239: 302-9. PMID 8706733  0.84
1996 Van Damme EJ, Barre A, Rougé P, Van Leuven F, Peumans WJ. Characterization and molecular cloning of Sambucus nigra agglutinin V (nigrin b), a GalNAc-specific type-2 ribosome-inactivating protein from the bark of elderberry (Sambucus nigra). European Journal of Biochemistry / Febs. 237: 505-13. PMID 8647092  0.84
1996 Moechars D, Lorent K, De Strooper B, Dewachter I, Van Leuven F. Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice. The Embo Journal. 15: 1265-74. PMID 8635459  0.84
1996 Van Damme EJ, Barre A, Rougé P, Van Leuven F, Peumans WJ. The NeuAc(alpha-2,6)-Gal/GalNAc-binding lectin from elderberry (Sambucus nigra) bark, a type-2 ribosome-inactivating protein with an unusual specificity and structure. European Journal of Biochemistry / Febs. 235: 128-37. PMID 8631319  0.84
1996 Medrano-Mercado N, Luz MR, Torrico F, Tapia G, Van Leuven F, Araujo-Jorge TC. Acute-phase proteins and serologic profiles of chagasic children from an endemic area in Bolivia. The American Journal of Tropical Medicine and Hygiene. 54: 154-61. PMID 8619440  0.84
1996 Van Damme EJ, Briké F, Winter HC, Van Leuven F, Goldstein IJ, Peumans WJ. Molecular cloning of two different mannose-binding lectins from tulip bulbs. European Journal of Biochemistry / Febs. 236: 419-27. PMID 8612611  0.84
1996 Terras FRG, Torrekens S, Van Leuven F, Broekaert WF. A six-cysteine type thionin from the radish storage organ displays weak in vitro antifungal activity against Fusarium culmorum Plant Physiology and Biochemistry. 34: 599-603.  0.84
1995 De Strooper B, Craessaerts K, Van Leuven F, Van Den Berghe H. Exchanging the extracellular domain of amyloid precursor protein for horseradish peroxidase does not interfere with alpha-secretase cleavage of the beta-amyloid region, but randomizes secretion in Madin-Darby canine kidney cells. The Journal of Biological Chemistry. 270: 30310-4. PMID 8530453  1
1995 De Strooper B, Craessaerts K, Dewachter I, Moechars D, Greenberg B, Van Leuven F, Van den Berghe H. Basolateral secretion of amyloid precursor protein in Madin-Darby canine kidney cells is disturbed by alterations of intracellular pH and by introducing a mutation associated with familial Alzheimer's disease. The Journal of Biological Chemistry. 270: 4058-65. PMID 7876155  1
1995 De Strooper B, Creemers JW, Moechars D, Huylebroeck D, Van De Ven WJ, Van Leuven F, Van den Berghe H. Amyloid precursor protein is not processed by furin, PACE 4, PC1/3, PC2, PC4 and PC5/6 of the furin family of proprotein processing enzymes. Biochimica Et Biophysica Acta. 1246: 185-8. PMID 7819286  1
1995 Van Leuven F, Hilliker C, Serneels L, Umans L, Overbergh L, De Strooper B, Fryns JP, Van den Berghe H. Cloning, characterization, and chromosomal localization to 4p16 of the human gene (LRPAP1) coding for the alpha 2-macroglobulin receptor-associated protein and structural comparison with the murine gene coding for the 44-kDa heparin-binding protein. Genomics. 25: 492-500. PMID 7789983  1
1995 Terras FR, Eggermont K, Kovaleva V, Raikhel NV, Osborn RW, Kester A, Rees SB, Torrekens S, Van Leuven F, Vanderleyden J. Small cysteine-rich antifungal proteins from radish: their role in host defense. The Plant Cell. 7: 573-88. PMID 7780308  0.84
1995 Van Damme EJ, Barre A, Smeets K, Torrekens S, Van Leuven F, Rougé P, Peumans WJ. The bark of Robinia pseudoacacia contains a complex mixture of lectins. Characterization of the proteins and the cDNA clones. Plant Physiology. 107: 833-43. PMID 7716244  0.52
1995 Spittaels K, Vankeerberghen A, Torrekens S, Devreese B, Grauwels L, Van Leuven F, Hunt D, Shabanowitz J, Schoofs L, Van Beeumen J. Isolation of Ala1-proctolin, the first natural analogue of proctolin, from the brain of the Colorado potato beetle. Molecular and Cellular Endocrinology. 110: 119-24. PMID 7672442 DOI: 10.1016/0303-7207(95)03527-E  0.84
1995 Spittaels K, Vankeerberghen A, Schoofs L, Torrekens S, Grauwels L, Van Leuven F, De Loof A. Identification, characterization, and immunological localization of a novel myotropic neuropeptide in the Colorado potato beetle, Leptinotarsa decemlineata. Peptides. 16: 365-74. PMID 7651886 DOI: 10.1016/0196-9781(94)00205-K  0.84
1995 Osborn RW, De Samblanx GW, Thevissen K, Goderis I, Torrekens S, Van Leuven F, Attenborough S, Rees SB, Broekaert WF. Isolation and characterisation of plant defensins from seeds of Asteraceae, Fabaceae, Hippocastanaceae and Saxifragaceae. Febs Letters. 368: 257-62. PMID 7628617  0.52
1995 Van Gool D, De Strooper B, Van Leuven F, Dom R. Amyloid precursor protein accumulation in Lewy body dementia and Alzheimer's disease. Dementia (Basel, Switzerland). 6: 63-8. PMID 7606281  1
1995 Overbergh L, Lorent K, Torrekens S, Van Leuven F, Van den Berghe H. Expression of mouse alpha-macroglobulins, lipoprotein receptor-related protein, LDL receptor, apolipoprotein E, and lipoprotein lipase in pregnancy. Journal of Lipid Research. 36: 1774-86. PMID 7595098  0.76
1995 De Strooper B, Simons M, Multhaup G, Van Leuven F, Beyreuther K, Dotti CG. Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence. The Embo Journal. 14: 4932-8. PMID 7588622  0.84
1995 Umans L, Serneels L, Overbergh L, Lorent K, Van Leuven F, Van den Berghe H. Targeted inactivation of the mouse alpha 2-macroglobulin gene. The Journal of Biological Chemistry. 270: 19778-85. PMID 7544347  0.76
1995 Lorent K, Overbergh L, Moechars D, De Strooper B, Van Leuven F, Van den Berghe H. Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lipase, alpha-2-macroglobulin and the 40,000 molecular weight receptor-associated protein. Neuroscience. 65: 1009-25. PMID 7542371  1
1995 Van Eynde A, Wera S, Beullens M, Torrekens S, Van Leuven F, Stalmans W, Bollen M. Molecular cloning of NIPP-1, a nuclear inhibitor of protein phosphatase-1, reveals homology with polypeptides involved in RNA processing. The Journal of Biological Chemistry. 270: 28068-74. PMID 7499293  0.52
1994 Hilliker C, Delabie J, Speleman F, Bilbe G, Bruggen J, Van Leuven F, Van den Berghe H. Localization of the gene (RSN) coding for restin, a marker for Reed-Sternberg cells in Hodgkin's disease, to human chromosome band 12q24.3 and YAC cloning of the locus. Cytogenetics and Cell Genetics. 65: 172-6. PMID 8222754  0.84
1994 Van Damme JM, Smeets K, Torrekens S, Van Leuven F, Peumans WJ. Characterization and molecular cloning of mannose-binding lectins from the Orchidaceae species Listera ovata, Epipactis helleborine and Cymbidium hybrid. European Journal of Biochemistry / Febs. 221: 769-77. PMID 8174556  0.52
1994 Van Leuven F, Serneels L, Raymakers L, Hilliker C, Umans L. The human and mouse genes coding for the alpha 2MR-associated protein. Annals of the New York Academy of Sciences. 737: 504-5. PMID 7944154  0.52
1994 Van Leuven F, Stas L, Raymakers L, Hilliker C. Structure of the human alpha 2M receptor gene. Annals of the New York Academy of Sciences. 737: 502-3. PMID 7944153  0.52
1994 Petit P, Hilliker C, Van Leuven F, Fryns JP. Mild phenotype and normal gonadal function in females with 4p trisomy due to unbalanced t(X;4)(p22.1;p14). Clinical Genetics. 46: 304-8. PMID 7834896  0.52
1994 van der Zee A, Stas L, Hilleker C, van Leuven F, van Dijk KW, Havekes L, Frants R, Hofker M. Genomic cloning of the mouse LDL receptor related protein/alpha 2-macroglobulin receptor gene. Genomics. 23: 256-9. PMID 7829084 DOI: 10.1006/geno.1994.1489  0.52
1994 Van Leuven F, Stas L, Hilliker C, Lorent K, Umans L, Serneels L, Overbergh L, Torrekens S, Moechars D, De Strooper B. Structure of the gene (LRP1) coding for the human alpha 2-macroglobulin receptor lipoprotein receptor-related protein. Genomics. 24: 78-89. PMID 7534747  1
1994 Overbergh L, Hilliker C, Lorent K, Van Leuven F, Van den Berghe H. Identification of four genes coding for isoforms of murinoglobulin, the monomeric mouse alpha 2-macroglobulin: characterization of the exons coding for the bait region. Genomics. 22: 530-9. PMID 7528167 DOI: 10.1006/geno.1994.1426  0.76
1994 Umans L, Serneels L, Hilliker C, Stas L, Overbergh L, De Strooper B, Van Leuven F, Van den Berghe H. Molecular cloning of the mouse gene coding for alpha 2-macroglobulin and targeting of the gene in embryonic stem cells. Genomics. 22: 519-29. PMID 7528166 DOI: 10.1006/geno.1994.1425  1
1994 Umans L, Serneels L, Hilliker C, Van Leuven F. Structure and targeting in ES cells of the gene coding for mouse alpha 2-macroglobulin. Annals of the New York Academy of Sciences. 737: 500-1. PMID 7524431  0.52
1994 Lorent K, Overbergh L, Van Leuven F. Expression of mouse alpha 2M and its receptor in vivo. Annals of the New York Academy of Sciences. 737: 498-9. PMID 7524430  0.52
1994 Overbergh L, Lorent K, Hilliker C, Van Leuven F. Characterization of the genes coding for the murinoglobulins and expression in vivo. Annals of the New York Academy of Sciences. 737: 496-7. PMID 7524429  0.52
1994 Van Leuven F, Umans L, Lorent K, Hilliker C, Serneels L, Overbergh L, Stas L, Raymakers L. Molecular analysis of the human and mouse alpha 2M family. Annals of the New York Academy of Sciences. 737: 163-71. PMID 7524394  0.52
1994 Lorent K, Overbergh L, Delabie J, Van Leuven F, Van den Berghe H. Distribution of mRNA coding for alpha-2-macroglobulin, the murinoglobulins, the alpha-2-macroglobulin receptor and the alpha-2-macroglobulin receptor associated protein during mouse embryogenesis and in adult tissues. Differentiation; Research in Biological Diversity. 55: 213-23. PMID 7514554  0.76
1993 Van Leuven F, Stas L, Raymakers L, Overbergh L, De Strooper B, Hilliker C, Lorent K, Fias E, Umans L, Torrekens S. Molecular cloning and sequencing of the murine alpha-2-macroglobulin receptor cDNA. Biochimica Et Biophysica Acta. 1173: 71-4. PMID 8485155  1
1993 De Strooper B, Umans L, Van Leuven F, Van Den Berghe H. Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway. The Journal of Cell Biology. 121: 295-304. PMID 8468348  1
1993 Terras FR, Torrekens S, Van Leuven F, Osborn RW, Vanderleyden J, Cammue BP, Broekaert WF. A new family of basic cysteine-rich plant antifungal proteins from Brassicaceae species. Febs Letters. 316: 233-40. PMID 8422949  0.52
1993 Van Damme JM, Smeets K, Torrekens S, Van Leuven F, Peumans WJ. The mannose-specific lectins from ramsons (Allium ursinum L.) are encoded by three sets of genes. European Journal of Biochemistry / Febs. 217: 123-9. PMID 8223549  0.52
1993 Delabie J, Bilbe G, Brüggen J, Van Leuven F, De Wolf-Peeters C. Restin in Hodgkin's disease and anaplastic large cell lymphoma. Leukemia & Lymphoma. 12: 21-6. PMID 8161933 DOI: 10.3109/10428199309059567  0.32
1993 Van Gool D, De Strooper B, Van Leuven F, Triau E, Dom R. alpha 2-Macroglobulin expression in neuritic-type plaques in patients with Alzheimer's disease. Neurobiology of Aging. 14: 233-7. PMID 7686641  1
1993 Van Leuven F, Torrekens S, Van den Berghe H. Isolation, characterization and partial sequencing of Pregnancy Associated Mouse Protein PAMP1 identifies it as a novel female specific protein, unrelated to the alpha-2-macroglobulin family of proteinase inhibitors. Febs Letters. 322: 219-22. PMID 7683611  0.76
1993 De Strooper B, Van Leuven F. Alpha 2-macroglobulin and subacute-phase responses in Alzheimer's disease. Immunology Today. 14: 143-4. PMID 7682079  1
1993 Van Leuven F, Torrekens S, Van Damme E, Peumans W, Van den Berghe H. Mannose-specific lectins bind alpha-2-macroglobulin and an unknown protein from human plasma. Protein Science : a Publication of the Protein Society. 2: 255-63. PMID 7680268 DOI: 10.1002/pro.5560020214  0.76
1993 Jaspers M, Vekemans S, Carmeliet G, van Leuven F, de Strooper B, Deckmyn H, Cassiman JJ. A monoclonal antibody to the alpha 2 integrin subunit cross-reacts with RGD-dependent epitopes in fibrinogen. Hybridoma. 12: 467-74. PMID 7503943  1
1992 Delabie J, Shipman R, Brüggen J, De Strooper B, van Leuven F, Tarcsay L, Cerletti N, Odink K, Diehl V, Bilbe G. Expression of the novel intermediate filament-associated protein restin in Hodgkin's disease and anaplastic large-cell lymphoma. Blood. 80: 2891-6. PMID 1450414  0.84
1992 Van Damme EJ, Smeets K, Torrekens S, Van Leuven F, Peumans WJ. Isolation and characterization of alliinase cDNA clones from garlic (Allium sativum L.) and related species. European Journal of Biochemistry / Febs. 209: 751-7. PMID 1385120  0.52
1992 De Strooper B, Van Leuven F, Van den Berghe H. Alpha 2-macroglobulin and other proteinase inhibitors do not interfere with the secretion of amyloid precursor protein in mouse neuroblastoma cells. Febs Letters. 308: 50-3. PMID 1379551  1
1992 Hilliker C, Overbergh L, Petit P, Van Leuven F, Van den Berghe H. Assignment of mouse alpha-2-macroglobulin gene to chromosome 6 band F1-G3. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 3: 469-71. PMID 1379499  0.76
1992 Hilliker C, Van Leuven F, Van den Berghe H. Assignment of the gene coding for the alpha 2-macroglobulin receptor to mouse chromosome 15 and to human chromosome 12q13-q14 by isotopic and nonisotopic in situ hybridization. Genomics. 13: 472-4. PMID 1377168  0.76
1992 van Damme EJ, Smeets K, Torrekens S, van Leuven F, Goldstein IJ, Peumans WJ. The closely related homomeric and heterodimeric mannose-binding lectins from garlic are encoded by one-domain and two-domain lectin genes, respectively. European Journal of Biochemistry / Febs. 206: 413-20. PMID 1375915  0.52
1992 Araujo-Jorge TC, Lage MJ, Rivera MT, Carlier Y, Van Leuven F. Trypanosoma cruzi: enhanced alpha-macroglobulin levels correlate with the resistance of BALB/cj mice to acute infection. Parasitology Research. 78: 215-21. PMID 1375380 DOI: 10.1007/BF00931729  0.84
1992 van Leuven F, Torrekens S, Overbergh L, Lorent K, de Strooper B, van den Berghe H. The primary sequence and the subunit structure of mouse alpha-2-macroglobulin, deduced from protein sequencing of the isolated subunits and from molecular cloning of the cDNA. European Journal of Biochemistry / Febs. 210: 319-27. PMID 1280217  1
1991 De Strooper B, Van Leuven F, Carmeliet G, Van Den Berghe H, Cassiman JJ. Cultured human fibroblasts contain a large pool of precursor beta 1-integrin but lack an intracellular pool of mature subunit. European Journal of Biochemistry / Febs. 199: 25-33. PMID 1906002  1
1991 Overbergh L, Torrekens S, Van Leuven F, Van den Berghe H. Molecular characterization of the murinoglobulins. The Journal of Biological Chemistry. 266: 16903-10. PMID 1840592  0.76
1991 De Strooper B, Van Leuven F, Van den Berghe H. The amyloid beta protein precursor or proteinase nexin II from mouse is closer related to its human homolog than previously reported. Biochimica Et Biophysica Acta. 1129: 141-3. PMID 1756177  1
1989 De Strooper B, Van der Schueren B, Jaspers M, Saison M, Spaepen M, Van Leuven F, Van den Berghe H, Cassiman JJ. Distribution of the beta 1 subgroup of the integrins in human cells and tissues. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 37: 299-307. PMID 2645360  1
1989 Devriendt K, Zhang J, van Leuven F, van den Berghe H, Cassiman JJ, Marynen P. A cluster of alpha 2-macroglobulin-related genes (alpha 2 M) on human chromosome 12p: cloning of the pregnancy-zone protein gene and an alpha 2M pseudogene. Gene. 81: 325-34. PMID 2478422  0.76
1988 De Strooper B, Saison M, Jaspers M, Spaepen M, Van Leuven F, Van den Berghe H, Cassiman JJ. Monoclonal antibody DH12 reacts with a cell surface and a precursor form of the beta subunit of the human fibronectin receptor. Cell Biology International Reports. 12: 9-16. PMID 2969294  1
1988 Jaspers M, de Strooper B, Spaepen M, van Leuven F, David G, van den Berghe H, Cassiman JJ. Post-translational modification of the beta-subunit of the human fibronectin receptor. Febs Letters. 231: 402-6. PMID 2966078  1
1988 Zhang Y, Saison M, Spaepen M, De Strooper B, Van Leuven F, David G, Van den Berghe H, Cassiman JJ. Mapping of human fibronectin receptor beta subunit gene to chromosome 10. Somatic Cell and Molecular Genetics. 14: 99-104. PMID 2963381  1
1988 Van Leuven F, Marynen P, Cassiman JJ, Van den Berghe H. Mapping of structure-function relationships in proteins with a panel of monoclonal antibodies. A study on human alpha 2 macroglobulin. Journal of Immunological Methods. 111: 39-49. PMID 2455752  0.76
1988 Delain E, Barray M, Tapon-Bretaudiere J, Pochon F, Marynen P, Cassiman JJ, Van den Berghe H, Van Leuven F. The molecular organization of human alpha 2-macroglobulin. An immunoelectron microscopic study with monoclonal antibodies. The Journal of Biological Chemistry. 263: 2981-9. PMID 2449433  0.76
1988 Van Leuven F, Marynen P, Cassiman JJ, Van den Berghe H. Proteolysis of human alpha 2-macroglobulin without hydrolysis of the internal thiolesters or expression of the receptor recognition site. The Journal of Biological Chemistry. 263: 468-71. PMID 2447076  0.76
1987 Van Leuven F, Marynen P, Cassiman JJ, Van den Berghe H. A mouse monoclonal antibody to human alpha 2-macroglobulin (alpha 2M) crossreacts with alpha 2M from mouse: epitope mapping and characterization of subunit structure of murine alpha 2M. Journal of Biochemistry. 101: 1181-9. PMID 2443487  0.76
1986 Verbist J, Wuytack F, Raeymaekers L, Van Leuven F, Cassiman JJ, Casteels R. A monoclonal antibody to the calmodulin-binding (Ca2+ + Mg2+)-dependent ATPase from pig stomach smooth muscle inhibits plasmalemmal (Ca2+ + Mg2+)-dependent ATPase activity. The Biochemical Journal. 240: 633-40. PMID 2950852  0.36
1986 Van Leuven F, Cassiman JJ, Van den Berghe H. Human pregnancy zone protein and alpha 2-macroglobulin. High-affinity binding of complexes to the same receptor on fibroblasts and characterization by monoclonal antibodies. The Journal of Biological Chemistry. 261: 16622-5. PMID 2430968  0.76
1986 Van Leuven F, Marynen P, Sottrup-Jensen L, Cassiman JJ, Van den Berghe H. The receptor-binding domain of human alpha 2-macroglobulin. Isolation after limited proteolysis with a bacterial proteinase. The Journal of Biological Chemistry. 261: 11369-73. PMID 2426272  0.76
1986 Van Leuven F, Marynen P, Cassiman JJ, Van den Berghe H. Reversed dot-blotting in hybridoma screening and epitope mapping. A model study with human alpha 2-macroglobulin to select complex-specific monoclonal antibodies. Journal of Immunological Methods. 90: 125-30. PMID 2423614  0.76
1986 Van Leuven F, Marynen P, Cassiman JJ, Van den Berghe H. The epitopes of two complex-specific monoclonal antibodies, related to the receptor recognition site, map to the COOH-terminal end of human alpha 2-macroglobulin. The Journal of Biological Chemistry. 261: 6933-7. PMID 2422174  0.76
1985 Van der Schueren B, Gasser D, Marynen P, Van Leuven F, David G, Cassiman JJ, Van den Berghe H. Polymorphous endocytotic organelles in the receptor-mediated endocytosis of gold-labelled alpha 2-macroglobulin complexes by human fibroblasts. Journal of Cell Science. 75: 411-21. PMID 2413062  0.76
1984 Marynen P, Van Leuven F, Cassiman JJ, Van den Berghe H. Solubilization and affinity purification of the alpha 2-macroglobulin receptor from human fibroblasts. The Journal of Biological Chemistry. 259: 7075-9. PMID 6427229  0.76
1984 Marynen P, Van Leuven F, Cassiman JJ, Van den Berghe H. alpha 2-Macroglobulin-proteinase complexes in cystic fibrosis serum. Analysis by monoclonal antibodies and receptor-mediated endocytosis by normal human fibroblasts. Biochimica Et Biophysica Acta. 799: 187-93. PMID 6203554  0.76
1983 Saison M, Verlinden J, Van Leuven F, Cassiman JJ, Van den Berghe H. Identification of cell surface dipeptidylpeptidase IV in human fibroblasts. The Biochemical Journal. 216: 177-83. PMID 6360158  0.76
1983 Saison M, Van Leuven F, Cassiman JJ, Van den Berghe H. Evidence for a role of fibronectin and other cell surface components in cell-cell layer adhesion of human fibroblasts. Experimental Cell Research. 143: 237-45. PMID 6337855  0.76
1983 Van Leuven F, Marynen P, Cassiman JJ, Van den Berghe H. Monoclonal antibodies toward the receptor-recognition site on alpha 2-macroglobulin complexes. Annals of the New York Academy of Sciences. 421: 434-41. PMID 6202217  0.76
1983 Marynen P, Van Leuven F, Cassiman JJ. Defective receptor binding of naturally occurring alpha 2-macroglobulin-protease complexes in cystic fibrosis by normal human fibroblasts. Annals of the New York Academy of Sciences. 421: 401-3. PMID 6202212  0.36
1982 Cassiman JJ, van der Schueren B, van Leuven F, van den Berghe H. Qualitative and quantitative differences in spreading of human fibroblasts on various protein coats. Modulation by treatment of the cells with amines. Journal of Cell Science. 54: 79-95. PMID 7076727  0.76
1982 de Martelaere D, Cassiman JJ, Van Leuven F, Van den Berghe H. Differences in the adhesive properties of osteosarcoma-derived clonal variants; enhanced by protease treatment. Progress in Clinical and Biological Research. 85: 647-58. PMID 6812069  0.76
1982 Marynen P, Van der Schueren B, Van Leuven F, Cassiman JJ, Van den Berghe H. Absence of specific binding of receptor-mediated endocytosis, and of secretion of alpha-2-macroglobulin by cultured endothelial cells. Haemostasis. 11: 210-4. PMID 6182057  0.76
1982 Van Leuven F, Marynen P, Cassiman JJ, Van den Berghe H. Relation of internal thioesters to conformational change and receptor-recognition site in alpha 2-macroglobulin complexes. The Biochemical Journal. 203: 405-11. PMID 6180729  0.76
1982 Van Leuven F, Cassiman JJ, Van den Berghe H. Functional modifications of alpha 2-macroglobulin by primary amines. Kinetics of inactivation of alpha 2-macroglobulin by methylamine, and formation of anomalous complexes with trypsin. The Biochemical Journal. 201: 119-28. PMID 6177314  0.76
1982 Marynen P, van Leuven F, Cassiman JJ, van den Berghe H. Proteolysis at a lysine residue abolishes the receptor-recognition site of alpha 2-macroglobulin complexes. Febs Letters. 137: 241-4. PMID 6174372  0.76
1982 De Martelaere D, Cassiman JJ, Van Leuven F, Verlinden J, Marynen P, Casteleyn J, Van den Berghe H. Human osteosarcoma derived clonal variants: stable differences in cell surface composition. Cell Biology International Reports. 6: 489-94. PMID 6124320  0.76
1981 Van Leuven F, Marynen P, Cassiman JJ, Van den Berghe H. Receptor-mediated endocytosis of alpha 2macroglobulin-protease complexes by fibroblasts in culture. Competitive inhibition by bacitracin. Febs Letters. 134: 83-7. PMID 9222330  0.76
1981 Verlinden J, Van Leuven F, Cassiman JJ, Van den Berghe H. Immunochemical characterization of a 150 000 dalton human fibroblast surface glycoprotein. Biochimica Et Biophysica Acta. 667: 1-14. PMID 7213789  0.76
1981 Verlinden J, Van Leuven F, Cassiman JJ, Van Den Berghe H. Application of crossed immunoelectrophoresis to the visualization and characterization of human fibroblast antigens. Cellular and Molecular Biology, Including Cyto-Enzymology. 27: 39-48. PMID 7016325  0.76
1981 Marynen P, Van Leuven F, Cassiman JJ, Van den Berghe H. A monoclonal antibody to a neo-antigen on alpha 2-macroglobulin complexes inhibits receptor-mediated endocytosis. Journal of Immunology (Baltimore, Md. : 1950). 127: 1782-6. PMID 6170673  0.76
1981 Cassiman JJ, Marynen P, Brugmans M, Van Leuven F, Van den Berghe H. Role of the alpha 2M-receptor in attachment and spreading of human fibroblasts. Cell Biology International Reports. 5: 901-11. PMID 6170464  0.76
1981 Van Leuven F, Cassiman JJ, Van den Berghe H. Functional modifications of alpha 2-macroglobulin by primary amines. II. Inhibition of covalent binding of trypsin to alpha 2 M by methylamine and other primary amines. The Journal of Biological Chemistry. 256: 9023-7. PMID 6167586  0.76
1981 Van Leuven F, Cassiman JJ, Van den Berghe H. Functional modifications of alpha 2-macroglobulin by primary amines. I. Characterization of alpha 2 M after derivatization by methylamine and by factor XIII. The Journal of Biological Chemistry. 256: 9016-22. PMID 6167585  0.76
1981 Cassiman JJ, Verlinden J, Van der Schueren B, Van Leuven F, Saison M, Van den Berghe H. Localization of a highly antigenic human fibroblast surface glycoprotein (FSG) on fibroblasts and on epithelia involved in secretion or resorption. Virchows Archiv. B, Cell Pathology Including Molecular Pathology. 37: 179-89. PMID 6115505  0.76
1981 Verlinden J, van Leuven F, Cassiman JJ, van den Berghe H. Identification of the human fibroblast surface glycoprotein (FSH) as aminopeptidase M. Febs Letters. 123: 287-90. PMID 6112164  0.76
1980 Cassiman JJ, van Leuven F, van der Schueren B, van den Berghe H. Immunohistochemical localization of human alpha 2Macroglobulin in connective tissue. Cell and Tissue Research. 213: 301-10. PMID 6161702  0.76
1980 Van Leuven F, Cassiman JJ, Van Den Berghe H. Primary amines inhibit recycling of alpha 2M receptors in fibroblasts. Cell. 20: 37-43. PMID 6156003  0.76
1979 Brugmans M, Cassiman JJ, Van Leuven F, Van den Berghe H. Quantitative assessment of the amount and the activity of trypsin associated with trypsinized cells. Cell Biology International Reports. 3: 257-63. PMID 445582  0.76
1979 Van Leuven F, Cassiman JJ, Van Den Berghe H. Anomalous alpha 2-macroglobulin-protease complexes in cystic fibrosis: decreased uptake of the complexes by fibroblasts in culture. Pediatric Research. 13: 1384-6. PMID 93265  0.76
1979 Van Leuven F, Cassiman JJ, Van Den Berghe H. Demonstration of an alpha2-macroglobulin receptor in human fibroblasts, absent in tumor-derived cell lines. The Journal of Biological Chemistry. 254: 5155-60. PMID 87392  0.76
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