| Year |
Citation |
Score |
| 2021 |
Ries M, Watts H, Mota BC, Lopez MY, Donat CK, Baxan N, Pickering JA, Chau TW, Semmler A, Gurung B, Aleksynas R, Abelleira-Hervas L, Iqbal SJ, Romero-Molina C, Hernandez-Mir G, ... ... Van Leuven F, et al. Annexin A1 restores cerebrovascular integrity concomitant with reduced amyloid-β and tau pathology. Brain : a Journal of Neurology. 144: 1526-1541. PMID 34148071 DOI: 10.1093/brain/awab050 |
0.348 |
|
| 2019 |
Govaerts K, Dresselaers T, Van Leuven F, Himmelreich U. Quantitative Assessment of Age-Associated Alterations in Brain Vasculature in Wild-Type Mice and in Bigenic Mice that Model Alzheimer's Disease. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. PMID 31297706 DOI: 10.1007/s11307-019-01402-w |
0.339 |
|
| 2019 |
Govaerts K, Lechat B, Struys T, Kremer A, Borghgraef P, Van Leuven F, Himmelreich U, Dresselaers T. Longitudinal assessment of cerebral perfusion and vascular response to hypoventilation in a bigenic mouse model of Alzheimer's disease with amyloid and tau pathology. Nmr in Biomedicine. 32: e4037. PMID 30489666 DOI: 10.1002/nbm.4037 |
0.342 |
|
| 2018 |
Rojo AI, Pajares M, García-Yagüe AJ, Buendia I, Van Leuven F, Yamamoto M, López MG, Cuadrado A. Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy. Redox Biology. 18: 173-180. PMID 30029164 DOI: 10.1016/J.Redox.2018.07.006 |
0.306 |
|
| 2017 |
Hoeijmakers L, Meerhoff GF, de Vries JW, Ruigrok SR, van Dam AM, van Leuven F, Korosi A, Lucassen PJ. The age-related slow increase in amyloid pathology in APP.V717I mice activates microglia, but does not alter hippocampal neurogenesis. Neurobiology of Aging. 61: 112-123. PMID 29059594 DOI: 10.1016/J.Neurobiolaging.2017.09.013 |
0.393 |
|
| 2017 |
Rojo AI, Pajares M, Rada P, Nuñez A, Nevado-Holgado AJ, Killik R, Van Leuven F, Ribe E, Lovestone S, Yamamoto M, Cuadrado A. NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology. Redox Biology. 13: 444-451. PMID 28704727 DOI: 10.1016/J.Redox.2017.07.006 |
0.335 |
|
| 2016 |
Pajares M, Jiménez-Moreno N, García-Yagüe ÁJ, Escoll M, de Ceballos ML, Van Leuven F, Rábano A, Yamamoto M, Rojo AI, Cuadrado A. Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes. Autophagy. 0. PMID 27427974 DOI: 10.1080/15548627.2016.1208889 |
0.342 |
|
| 2016 |
Lesuis SL, Maurin H, Borghgraef P, Lucassen PJ, Van Leuven F, Krugers HJ. Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer's disease. Oncotarget. PMID 27259247 DOI: 10.18632/Oncotarget.9776 |
0.338 |
|
| 2016 |
Brendel M, Jaworska A, Probst F, Overhoff F, Korzhova V, Lindner S, Carlsen J, Bartenstein P, Harada R, Kudo Y, Haass C, van Leuven F, Okamura N, Herms J, Rominger A. microPET Imaging of Tau Pathology with [18F]-THK5117 in two Transgenic Mouse Models. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 26912432 DOI: 10.2967/Jnumed.115.163493 |
0.537 |
|
| 2015 |
Ochs SM, Dorostkar MM, Aramuni G, Schön C, Filser S, Pöschl J, Kremer A, Van Leuven F, Ovsepian SV, Herms J. Loss of neuronal GSK3β reduces dendritic spine stability and attenuates excitatory synaptic transmission via β-catenin. Molecular Psychiatry. 20: 482-9. PMID 24912492 DOI: 10.1038/Mp.2014.55 |
0.477 |
|
| 2014 |
Kukreja L, Kujoth GC, Prolla TA, Van Leuven F, Vassar R. Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease. Molecular Neurodegeneration. 9: 16. PMID 24885175 DOI: 10.1186/1750-1326-9-16 |
0.371 |
|
| 2014 |
Maurin H, Lechat B, Borghgraef P, Devijver H, Jaworski T, Van Leuven F. Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3α/β. The European Journal of Neuroscience. 40: 2442-53. PMID 24754737 DOI: 10.1111/ejn.12595 |
0.351 |
|
| 2014 |
Crespo-Biel N, Theunis C, Borghgraef P, Lechat B, Devijver H, Maurin H, Van Leuven F. Phosphorylation of protein Tau by GSK3β prolongs survival of bigenic Tau.P301L×GSK3β mice by delaying brainstem tauopathy. Neurobiology of Disease. 67: 119-32. PMID 24704314 DOI: 10.1016/j.nbd.2014.03.016 |
0.356 |
|
| 2014 |
Lastres-Becker I, Innamorato NG, Jaworski T, Rábano A, Kügler S, Van Leuven F, Cuadrado A. Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis. Brain : a Journal of Neurology. 137: 78-91. PMID 24277722 DOI: 10.1093/Brain/Awt323 |
0.376 |
|
| 2013 |
Theunis C, Crespo-Biel N, Gafner V, Pihlgren M, López-Deber MP, Reis P, Hickman DT, Adolfsson O, Chuard N, Ndao DM, Borghgraef P, Devijver H, Van Leuven F, Pfeifer A, Muhs A. Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau.P301L mice that model tauopathy. Plos One. 8: e72301. PMID 23977276 DOI: 10.1371/journal.pone.0072301 |
0.343 |
|
| 2013 |
Maurin H, Lechat B, Dewachter I, Ris L, Louis JV, Borghgraef P, Devijver H, Jaworski T, Van Leuven F. Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase. Molecular Brain. 6: 27. PMID 23705847 DOI: 10.1186/1756-6606-6-27 |
0.306 |
|
| 2013 |
Maurin H, Seymour CM, Lechat B, Borghgraef P, Devijver H, Jaworski T, Schmidt MV, Kuegler S, Van Leuven F. Tauopathy differentially affects cell adhesion molecules in mouse brain: early down-regulation of nectin-3 in stratum lacunosum moleculare. Plos One. 8: e63589. PMID 23704923 DOI: 10.1371/Journal.Pone.0063589 |
0.332 |
|
| 2013 |
Kondratiuk I, Devijver H, Lechat B, Van Leuven F, Kaczmarek L, Filipkowski RK. Glycogen synthase kinase-3beta affects size of dentate gyrus and species-typical behavioral tasks in transgenic and knockout mice. Behavioural Brain Research. 248: 46-50. PMID 23570858 DOI: 10.1016/j.bbr.2013.03.045 |
0.303 |
|
| 2013 |
Barao S, Zhou L, Adamczuk K, Vanhoutvin T, van Leuven F, Demedts D, Vijverman AC, Bossuyt X, Vandenberghe R, De Strooper B. BACE1 levels correlate with phospho-tau levels in human cerebrospinal fluid. Current Alzheimer Research. 10: 671-8. PMID 23566348 DOI: 10.2174/15672050113109990138 |
0.481 |
|
| 2013 |
Gandy JC, Melendez-Ferro M, Bijur GN, Van Leuven F, Roche JK, Lechat B, Devijver H, Demedts D, Perez-Costas E, Roberts RC. Glycogen synthase kinase-3β (GSK3β) expression in a mouse model of Alzheimer's disease: a light and electron microscopy study. Synapse (New York, N.Y.). 67: 313-27. PMID 23390016 DOI: 10.1002/Syn.21642 |
0.774 |
|
| 2012 |
Parr C, Carzaniga R, Gentleman SM, Van Leuven F, Walter J, Sastre M. Glycogen synthase kinase 3 inhibition promotes lysosomal biogenesis and autophagic degradation of the amyloid-β precursor protein. Molecular and Cellular Biology. 32: 4410-8. PMID 22927642 DOI: 10.1128/MCB.00930-12 |
0.339 |
|
| 2012 |
Crespo-Biel N, Theunis C, Van Leuven F. Protein tau: prime cause of synaptic and neuronal degeneration in Alzheimer's disease. International Journal of Alzheimer's Disease. 2012: 251426. PMID 22720188 DOI: 10.1155/2012/251426 |
0.335 |
|
| 2012 |
Menuet C, Borghgraef P, Voituron N, Gestreau C, Gielis L, Devijver H, Dutschmann M, Van Leuven F, Hilaire G. Isoflurane anesthesia precipitates tauopathy and upper airways dysfunction in pre-symptomatic Tau.P301L mice: possible implication for neurodegenerative diseases. Neurobiology of Disease. 46: 234-43. PMID 22316605 DOI: 10.1016/j.nbd.2012.01.012 |
0.307 |
|
| 2011 |
Kremer A, Maurin H, Demedts D, Devijver H, Borghgraef P, Van Leuven F. Early improved and late defective cognition is reflected by dendritic spines in Tau.P301L mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 18036-47. PMID 22159117 DOI: 10.1523/JNEUROSCI.4859-11.2011 |
0.343 |
|
| 2011 |
Jaworski T, Dewachter I, Lechat B, Gees M, Kremer A, Demedts D, Borghgraef P, Devijver H, Kügler S, Patel S, Woodgett JR, Van Leuven F. GSK-3α/β kinases and amyloid production in vivo. Nature. 480: E4-5; discussion E6. PMID 22158250 DOI: 10.1038/Nature10615 |
0.312 |
|
| 2011 |
Menuet C, Cazals Y, Gestreau C, Borghgraef P, Gielis L, Dutschmann M, Van Leuven F, Hilaire G. Age-related impairment of ultrasonic vocalization in Tau.P301L mice: possible implication for progressive language disorders. Plos One. 6: e25770. PMID 22022446 DOI: 10.1371/journal.pone.0025770 |
0.312 |
|
| 2011 |
Jung CK, Fuhrmann M, Honarnejad K, Van Leuven F, Herms J. Role of presenilin 1 in structural plasticity of cortical dendritic spines in vivo. Journal of Neurochemistry. 119: 1064-73. PMID 21951279 DOI: 10.1111/J.1471-4159.2011.07503.X |
0.566 |
|
| 2011 |
Kremer A, Louis JV, Jaworski T, Van Leuven F. GSK3 and Alzheimer's Disease: Facts and Fiction…. Frontiers in Molecular Neuroscience. 4: 17. PMID 21904524 DOI: 10.3389/fnmol.2011.00017 |
0.311 |
|
| 2011 |
Jaworski T, Lechat B, Demedts D, Gielis L, Devijver H, Borghgraef P, Duimel H, Verheyen F, Kügler S, Van Leuven F. Dendritic degeneration, neurovascular defects, and inflammation precede neuronal loss in a mouse model for tau-mediated neurodegeneration. The American Journal of Pathology. 179: 2001-15. PMID 21839061 DOI: 10.1016/j.ajpath.2011.06.025 |
0.404 |
|
| 2011 |
Chong SA, Benilova I, Shaban H, De Strooper B, Devijver H, Moechars D, Eberle W, Bartic C, Van Leuven F, Callewaert G. Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: a multi-electrode array study. Neurobiology of Disease. 44: 284-91. PMID 21807097 DOI: 10.1016/J.Nbd.2011.07.006 |
0.564 |
|
| 2011 |
Rat D, Schmitt U, Tippmann F, Dewachter I, Theunis C, Wieczerzak E, Postina R, van Leuven F, Fahrenholz F, Kojro E. Neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) slows down Alzheimer's disease-like pathology in amyloid precursor protein-transgenic mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 3208-18. PMID 21593432 DOI: 10.1096/fj.10-180133 |
0.388 |
|
| 2011 |
Zhou L, Brouwers N, Benilova I, Vandersteen A, Mercken M, Van Laere K, Van Damme P, Demedts D, Van Leuven F, Sleegers K, Broersen K, Van Broeckhoven C, Vandenberghe R, De Strooper B. Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation. Embo Molecular Medicine. 3: 291-302. PMID 21500352 DOI: 10.1002/Emmm.201100138 |
0.469 |
|
| 2011 |
Rolyan H, Feike AC, Upadhaya AR, Waha A, Van Dooren T, Haass C, Birkenmeier G, Pietrzik CU, Van Leuven F, Thal DR. Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer's disease. Journal of Neural Transmission (Vienna, Austria : 1996). 118: 699-712. PMID 21210284 DOI: 10.1007/S00702-010-0572-7 |
0.44 |
|
| 2010 |
Tanghe A, Termont A, Merchiers P, Schilling S, Demuth HU, Scrocchi L, Van Leuven F, Griffioen G, Van Dooren T. Pathological Hallmarks, Clinical Parallels, and Value for Drug Testing in Alzheimer's Disease of the APP[V717I] London Transgenic Mouse Model. International Journal of Alzheimer's Disease. 2010. PMID 20862386 DOI: 10.4061/2010/417314 |
0.319 |
|
| 2010 |
Jaworski T, Kügler S, Van Leuven F. Modeling of tau-mediated synaptic and neuronal degeneration in Alzheimer's disease. International Journal of Alzheimer's Disease. 2010. PMID 20862366 DOI: 10.4061/2010/573138 |
0.348 |
|
| 2010 |
Hillen H, Barghorn S, Striebinger A, Labkovsky B, Müller R, Nimmrich V, Nolte MW, Perez-Cruz C, van der Auwera I, van Leuven F, van Gaalen M, Bespalov AY, Schoemaker H, Sullivan JP, Ebert U. Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 10369-79. PMID 20685980 DOI: 10.1523/JNEUROSCI.5721-09.2010 |
0.363 |
|
| 2010 |
Sala Frigerio C, Fadeeva JV, Minogue AM, Citron M, Van Leuven F, Staufenbiel M, Paganetti P, Selkoe DJ, Walsh DM. beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins. The Febs Journal. 277: 1503-18. PMID 20163459 DOI: 10.1111/j.1742-4658.2010.07579.x |
0.342 |
|
| 2010 |
Dutschmann M, Menuet C, Stettner GM, Gestreau C, Borghgraef P, Devijver H, Gielis L, Hilaire G, Van Leuven F. Upper airway dysfunction of Tau-P301L mice correlates with tauopathy in midbrain and ponto-medullary brainstem nuclei. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 1810-21. PMID 20130190 DOI: 10.1523/JNEUROSCI.5261-09.2010 |
0.357 |
|
| 2009 |
Jaworski T, Dewachter I, Lechat B, Croes S, Termont A, Demedts D, Borghgraef P, Devijver H, Filipkowski RK, Kaczmarek L, Kügler S, Van Leuven F. AAV-tau mediates pyramidal neurodegeneration by cell-cycle re-entry without neurofibrillary tangle formation in wild-type mice. Plos One. 4: e7280. PMID 19794916 DOI: 10.1371/journal.pone.0007280 |
0.421 |
|
| 2009 |
Jansen PJ, Lütjohann D, Thelen KM, von Bergmann K, van Leuven F, Ramaekers FC, Monique M. Absence of ApoE upregulates murine brain ApoD and ABCA1 levels, but does not affect brain sterol levels, while human ApoE3 and human ApoE4 upregulate brain cholesterol precursor levels. Journal of Alzheimer's Disease : Jad. 18: 319-29. PMID 19584433 DOI: 10.3233/JAD-2009-1150 |
0.317 |
|
| 2009 |
Lim JC, Mickute Z, Zaman M, Hopkins S, Wijesuriya H, Steckler T, Moechars D, Van Leuven F, Sarnyai Z, Hladky SB, Barrand MA. Decreased expression of multidrug efflux transporters in the brains of GSK-3beta transgenic mice. Brain Research. 1276: 1-10. PMID 19393634 DOI: 10.1016/j.brainres.2009.04.031 |
0.33 |
|
| 2009 |
Serdons K, Verduyckt T, Vanderghinste D, Borghgraef P, Cleynhens J, Van Leuven F, Kung H, Bormans G, Verbruggen A. 11C-labelled PIB analogues as potential tracer agents for in vivo imaging of amyloid beta in Alzheimer's disease. European Journal of Medicinal Chemistry. 44: 1415-26. PMID 18992967 DOI: 10.1016/J.Ejmech.2008.09.038 |
0.353 |
|
| 2009 |
Dewachter I, Filipkowski RK, Priller C, Ris L, Neyton J, Croes S, Terwel D, Gysemans M, Devijver H, Borghgraef P, Godaux E, Kaczmarek L, Herms J, Van Leuven F. Deregulation of NMDA-receptor function and down-stream signaling in APP[V717I] transgenic mice. Neurobiology of Aging. 30: 241-56. PMID 17673336 DOI: 10.1016/J.Neurobiolaging.2007.06.011 |
0.525 |
|
| 2008 |
Tamboli IY, Prager K, Thal DR, Thelen KM, Dewachter I, Pietrzik CU, St George-Hyslop P, Sisodia SS, De Strooper B, Heneka MT, Filippov MA, Müller U, van Leuven F, Lütjohann D, Walter J. Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12097-106. PMID 19005074 DOI: 10.1523/Jneurosci.2635-08.2008 |
0.52 |
|
| 2008 |
Hirata-Fukae C, Sidahmed EH, Gooskens TP, Aisen PS, Dewachter I, Devijver H, Van Leuven F, Matsuoka Y. Beta-site amyloid precursor protein-cleaving enzyme-1 (BACE1)-mediated changes of endogenous amyloid beta in wild-type and transgenic mice in vivo. Neuroscience Letters. 435: 186-9. PMID 18343582 DOI: 10.1016/J.Neulet.2008.02.032 |
0.389 |
|
| 2008 |
Terwel D, Muyllaert D, Dewachter I, Borghgraef P, Croes S, Devijver H, Van Leuven F. Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice. The American Journal of Pathology. 172: 786-98. PMID 18258852 DOI: 10.2353/ajpath.2008.070904 |
0.409 |
|
| 2008 |
Dewachter I, Ris L, Croes S, Borghgraef P, Devijver H, Voets T, Nilius B, Godaux E, Van Leuven F. Modulation of synaptic plasticity and Tau phosphorylation by wild-type and mutant presenilin1. Neurobiology of Aging. 29: 639-52. PMID 17222948 DOI: 10.1016/j.neurobiolaging.2006.11.019 |
0.348 |
|
| 2007 |
Sennvik K, Boekhoorn K, Lasrado R, Terwel D, Verhaeghe S, Korr H, Schmitz C, Tomiyama T, Mori H, Krugers H, Joels M, Ramakers GJ, Lucassen PJ, Van Leuven F. Tau-4R suppresses proliferation and promotes neuronal differentiation in the hippocampus of tau knockin/knockout mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 2149-61. PMID 17341679 DOI: 10.1096/Fj.06-7735Com |
0.32 |
|
| 2007 |
Priller C, Dewachter I, Vassallo N, Paluch S, Pace C, Kretzschmar HA, Van Leuven F, Herms J. Mutant presenilin 1 alters synaptic transmission in cultured hippocampal neurons. The Journal of Biological Chemistry. 282: 1119-27. PMID 17088253 DOI: 10.1074/Jbc.M605066200 |
0.512 |
|
| 2007 |
Thal DR, Larionov S, Abramowski D, Wiederhold KH, Van Dooren T, Yamaguchi H, Haass C, Van Leuven F, Staufenbiel M, Capetillo-Zarate E. Occurrence and co-localization of amyloid beta-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice. Neurobiology of Aging. 28: 1221-30. PMID 16815595 DOI: 10.1016/J.Neurobiolaging.2006.05.029 |
0.371 |
|
| 2006 |
Muyllaert D, Terwel D, Borghgraef P, Devijver H, Dewachter I, Van Leuven F. Transgenic mouse models for Alzheimer's disease: the role of GSK-3B in combined amyloid and tau-pathology. Revue Neurologique. 162: 903-7. PMID 17028556 |
0.415 |
|
| 2006 |
Boekhoorn K, Terwel D, Biemans B, Borghgraef P, Wiegert O, Ramakers GJ, de Vos K, Krugers H, Tomiyama T, Mori H, Joels M, van Leuven F, Lucassen PJ. Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 3514-23. PMID 16571759 DOI: 10.1523/Jneurosci.5425-05.2006 |
0.322 |
|
| 2006 |
Van Dooren T, Muyllaert D, Borghgraef P, Cresens A, Devijver H, Van der Auwera I, Wera S, Dewachter I, Van Leuven F. Neuronal or glial expression of human apolipoprotein e4 affects parenchymal and vascular amyloid pathology differentially in different brain regions of double- and triple-transgenic mice. The American Journal of Pathology. 168: 245-60. PMID 16400027 DOI: 10.2353/ajpath.2006.050752 |
0.449 |
|
| 2005 |
Heneka MT, Sastre M, Dumitrescu-Ozimek L, Dewachter I, Walter J, Klockgether T, Van Leuven F. Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice. Journal of Neuroinflammation. 2: 22. PMID 16212664 DOI: 10.1186/1742-2094-2-22 |
0.415 |
|
| 2005 |
Zurbriggen R, Amacker M, Kammer AR, Westerfeld N, Borghgraef P, Van Leuven F, Van der Auwera I, Wera S. Virosome-based active immunization targets soluble amyloid species rather than plaques in a transgenic mouse model of Alzheimer's disease. Journal of Molecular Neuroscience : Mn. 27: 157-66. PMID 16186626 DOI: 10.1385/JMN:27:2:157 |
0.321 |
|
| 2005 |
Vandebroek T, Vanhelmont T, Terwel D, Borghgraef P, Lemaire K, Snauwaert J, Wera S, Van Leuven F, Winderickx J. Identification and isolation of a hyperphosphorylated, conformationally changed intermediate of human protein tau expressed in yeast. Biochemistry. 44: 11466-75. PMID 16114883 DOI: 10.1021/bi0506775 |
0.315 |
|
| 2005 |
Heneka MT, Sastre M, Dumitrescu-Ozimek L, Hanke A, Dewachter I, Kuiperi C, O'Banion K, Klockgether T, Van Leuven F, Landreth GE. Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. Brain : a Journal of Neurology. 128: 1442-53. PMID 15817521 DOI: 10.1093/Brain/Awh452 |
0.328 |
|
| 2005 |
Vanhoutte G, Dewachter I, Borghgraef P, Van Leuven F, Van der Linden A. Noninvasive in vivo MRI detection of neuritic plaques associated with iron in APP[V717I] transgenic mice, a model for Alzheimer's disease. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 53: 607-13. PMID 15723413 DOI: 10.1002/mrm.20385 |
0.366 |
|
| 2005 |
van Dooren T, Dewachter I, Borghgraef P, van Leuven F. Transgenic mouse models for APP processing and Alzheimer's disease: early and late defects. Sub-Cellular Biochemistry. 38: 45-63. PMID 15709472 |
0.424 |
|
| 2005 |
Terwel D, Lasrado R, Snauwaert J, Vandeweert E, Van Haesendonck C, Borghgraef P, Van Leuven F. Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice. The Journal of Biological Chemistry. 280: 3963-73. PMID 15509565 DOI: 10.1074/jbc.M409876200 |
0.301 |
|
| 2004 |
Boom A, Pochet R, Authelet M, Pradier L, Borghgraef P, Van Leuven F, Heizmann CW, Brion JP. Astrocytic calcium/zinc binding protein S100A6 over expression in Alzheimer's disease and in PS1/APP transgenic mice models. Biochimica Et Biophysica Acta. 1742: 161-8. PMID 15590066 DOI: 10.1016/j.bbamcr.2004.09.011 |
0.362 |
|
| 2004 |
Willem M, Dewachter I, Smyth N, Van Dooren T, Borghgraef P, Haass C, Van Leuven F. beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice. The American Journal of Pathology. 165: 1621-31. PMID 15509532 DOI: 10.1016/S0002-9440(10)63419-0 |
0.381 |
|
| 2004 |
Etcheberrigaray R, Tan M, Dewachter I, Kuipéri C, Van der Auwera I, Wera S, Qiao L, Bank B, Nelson TJ, Kozikowski AP, Van Leuven F, Alkon DL. Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 101: 11141-6. PMID 15263077 DOI: 10.1073/pnas.0403921101 |
0.355 |
|
| 2004 |
Postina R, Schroeder A, Dewachter I, Bohl J, Schmitt U, Kojro E, Prinzen C, Endres K, Hiemke C, Blessing M, Flamez P, Dequenne A, Godaux E, van Leuven F, Fahrenholz F. A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. The Journal of Clinical Investigation. 113: 1456-64. PMID 15146243 DOI: 10.1172/JCI20864 |
0.414 |
|
| 2003 |
Frenkel D, Dewachter I, Van Leuven F, Solomon B. Reduction of beta-amyloid plaques in brain of transgenic mouse model of Alzheimer's disease by EFRH-phage immunization. Vaccine. 21: 1060-5. PMID 12559780 DOI: 10.1016/S0264-410X(02)00609-6 |
0.375 |
|
| 2003 |
Herms J, Schneider I, Dewachter I, Caluwaerts N, Kretzschmar H, Van Leuven F. Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein. The Journal of Biological Chemistry. 278: 2484-9. PMID 12431992 DOI: 10.1074/Jbc.M206769200 |
0.534 |
|
| 2003 |
Van Dorpe J, Spittaels K, Van den Haute CV, Dewachter I, Moechars D, Geerts H, Van Leuven F. Neuropathobiology in transgenic mice. The case of Alzheimer's disease. Methods in Molecular Biology (Clifton, N.J.). 209: 333-61. PMID 12357960 |
0.325 |
|
| 2002 |
Dewachter I, Van Leuven F. Secretases as targets for the treatment of Alzheimer's disease: the prospects. The Lancet. Neurology. 1: 409-16. PMID 12849363 DOI: 10.1016/S1474-4422(02)00188-6 |
0.336 |
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| 2002 |
Terwel D, Dewachter I, Van Leuven F. Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease. Neuromolecular Medicine. 2: 151-65. PMID 12428809 DOI: 10.1385/NMM:2:2:151 |
0.36 |
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| 2002 |
Künzi V, Glatzel M, Nakano MY, Greber UF, Van Leuven F, Aguzzi A. Unhampered prion neuroinvasion despite impaired fast axonal transport in transgenic mice overexpressing four-repeat tau. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 7471-7. PMID 12196569 DOI: 10.1523/Jneurosci.22-17-07471.2002 |
0.307 |
|
| 2002 |
Spittaels K, Van den Haute C, Van Dorpe J, Terwel D, Vandezande K, Lasrado R, Bruynseels K, Irizarry M, Verhoye M, Van Lint J, Vandenheede JR, Ashton D, Mercken M, Loos R, Hyman B, ... ... Van Leuven F, et al. Neonatal neuronal overexpression of glycogen synthase kinase-3 beta reduces brain size in transgenic mice. Neuroscience. 113: 797-808. PMID 12182887 DOI: 10.1016/S0306-4522(02)00236-1 |
0.316 |
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| 2002 |
Tilleman K, Van den Haute C, Geerts H, van Leuven F, Esmans EL, Moens L. Proteomics analysis of the neurodegeneration in the brain of tau transgenic mice. Proteomics. 2: 656-65. PMID 12112845 DOI: 10.1002/1615-9861(200206)2:6<656::Aid-Prot656>3.0.Co;2-Z |
0.403 |
|
| 2002 |
Dewachter I, Reversé D, Caluwaerts N, Ris L, Kuipéri C, Van den Haute C, Spittaels K, Umans L, Serneels L, Thiry E, Moechars D, Mercken M, Godaux E, Van Leuven F. Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 3445-53. PMID 11978821 |
0.444 |
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| 2002 |
Permanne B, Adessi C, Saborio GP, Fraga S, Frossard MJ, Van Dorpe J, Dewachter I, Banks WA, Van Leuven F, Soto C. Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a beta-sheet breaker peptide. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 860-2. PMID 11967228 DOI: 10.1096/Fj.01-0841Fje |
0.333 |
|
| 2002 |
Nuydens R, Van Den Kieboom G, Nolten C, Verhulst C, Van Osta P, Spittaels K, Van den Haute C, De Feyter E, Geerts H, Van Leuven F. Coexpression of GSK-3beta corrects phenotypic aberrations of dorsal root ganglion cells, cultured from adult transgenic mice overexpressing human protein tau. Neurobiology of Disease. 9: 38-48. PMID 11848683 DOI: 10.1006/nbdi.2001.0454 |
0.308 |
|
| 2002 |
Tilleman K, Stevens I, Spittaels K, Haute CV, Clerens S, Van Den Bergh G, Geerts H, Van Leuven F, Vandesande F, Moens L. Differential expression of brain proteins in glycogen synthase kinase-3 transgenic mice: a proteomics point of view. Proteomics. 2: 94-104. PMID 11788996 DOI: 10.1002/1615-9861(200201)2:1<94::Aid-Prot94>3.0.Co;2-W |
0.385 |
|
| 2001 |
Dewachter I, Moechars D, van Dorpe J, Tesseur I, Van den Haute C, Spittaels K, Van Leuven F. Modelling Alzheimer's disease in multiple transgenic mice. Biochemical Society Symposium. 203-10. PMID 11447836 DOI: 10.1042/Bss0670203 |
0.748 |
|
| 2001 |
Schneider I, Reverse D, Dewachter I, Ris L, Caluwaerts N, Kuiperi C, Gilis M, Geerts H, Kretzschmar H, Godaux E, Moechars D, Van Leuven F, Herms J. Mutant presenilins disturb neuronal calcium homeostasis in the brain of transgenic mice, decreasing the threshold for excitotoxicity and facilitating long-term potentiation. The Journal of Biological Chemistry. 276: 11539-44. PMID 11278803 DOI: 10.1074/Jbc.M010977200 |
0.531 |
|
| 2001 |
Van den Haute C, Spittaels K, Van Dorpe J, Lasrado R, Vandezande K, Laenen I, Geerts H, Van Leuven F. Coexpression of human cdk5 and its activator p35 with human protein tau in neurons in brain of triple transgenic mice. Neurobiology of Disease. 8: 32-44. PMID 11162238 DOI: 10.1006/nbdi.2000.0333 |
0.373 |
|
| 2000 |
Tesseur I, Van Dorpe J, Bruynseels K, Bronfman F, Sciot R, Van Lommel A, Van Leuven F. Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord. The American Journal of Pathology. 157: 1495-510. PMID 11073810 DOI: 10.1016/S0002-9440(10)64788-8 |
0.773 |
|
| 2000 |
Dewachter I, van Dorpe J, Spittaels K, Tesseur I, Van Den Haute C, Moechars D, Van Leuven F. Modeling Alzheimer's disease in transgenic mice: effect of age and of presenilin1 on amyloid biochemistry and pathology in APP/London mice. Experimental Gerontology. 35: 831-41. PMID 11053674 DOI: 10.1016/S0531-5565(00)00149-2 |
0.761 |
|
| 2000 |
Van Dorpe J, Smeijers L, Dewachter I, Nuyens D, Spittaels K, Van Den Haute C, Mercken M, Moechars D, Laenen I, Kuiperi C, Bruynseels K, Tesseur I, Loos R, Vanderstichele H, Checler F, ... ... Van Leuven F, et al. Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons. The American Journal of Pathology. 157: 1283-98. PMID 11021833 DOI: 10.1016/S0197-4580(00)82614-7 |
0.718 |
|
| 2000 |
Spittaels K, Van den Haute C, Van Dorpe J, Geerts H, Mercken M, Bruynseels K, Lasrado R, Vandezande K, Laenen I, Boon T, Van Lint J, Vandenheede J, Moechars D, Loos R, Van Leuven F. Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice. The Journal of Biological Chemistry. 275: 41340-9. PMID 11007782 DOI: 10.1074/jbc.M006219200 |
0.347 |
|
| 2000 |
Dewachter I, Van Dorpe J, Smeijers L, Gilis M, Kuipéri C, Laenen I, Caluwaerts N, Moechars D, Checler F, Vanderstichele H, Van Leuven F. Aging increased amyloid peptide and caused amyloid plaques in brain of old APP/V717I transgenic mice by a different mechanism than mutant presenilin1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 6452-8. PMID 10964951 |
0.417 |
|
| 2000 |
Bronfman FC, Moechars D, Van Leuven F. Acetylcholinesterase-positive fiber deafferentation and cell shrinkage in the septohippocampal pathway of aged amyloid precursor protein london mutant transgenic mice. Neurobiology of Disease. 7: 152-68. PMID 10860782 DOI: 10.1006/Nbdi.2000.0283 |
0.706 |
|
| 2000 |
Masliah E, Alford M, Mallory M, Rockenstein E, Moechars D, Van Leuven F. Abnormal glutamate transport function in mutant amyloid precursor protein transgenic mice. Experimental Neurology. 163: 381-7. PMID 10833311 DOI: 10.1006/Exnr.2000.7386 |
0.329 |
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| 2000 |
Bronfman FC, Tesseur I, Hofker MH, Havekens LM, Van Leuven F. No evidence for cholinergic problems in apolipoprotein E knockout and apolipoprotein E4 transgenic mice. Neuroscience. 97: 411-8. PMID 10828523 DOI: 10.1016/S0306-4522(00)00016-6 |
0.774 |
|
| 2000 |
van Leuven F. Single and multiple transgenic mice as models for Alzheimer's disease. Progress in Neurobiology. 61: 305-12. PMID 10727777 DOI: 10.1016/S0301-0082(99)00055-6 |
0.446 |
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| 2000 |
Tesseur I, Van Dorpe J, Spittaels K, Van den Haute C, Moechars D, Van Leuven F. Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice. The American Journal of Pathology. 156: 951-64. PMID 10702411 DOI: 10.1016/S0002-9440(10)64963-2 |
0.738 |
|
| 2000 |
Kumar-Singh S, Dewachter I, Moechars D, Lübke U, De Jonghe C, Ceuterick C, Checler F, Naidu A, Cordell B, Cras P, Van Broeckhoven C, Van Leuven F. Behavioral disturbances without amyloid deposits in mice overexpressing human amyloid precursor protein with Flemish (A692G) or Dutch (E693Q) mutation. Neurobiology of Disease. 7: 9-22. PMID 10671319 DOI: 10.1006/nbdi.1999.0272 |
0.446 |
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| 1999 |
Umans L, Serneels L, Lorent K, Dewachter I, Tesseur I, Moechars D, Van Leuven F. Lipoprotein receptor-related protein in brain and in cultured neurons of mice deficient in receptor-associated protein and transgenic for apolipoprotein E4 or amyloid precursor protein. Neuroscience. 94: 315-21. PMID 10613521 DOI: 10.1016/S0306-4522(99)00242-0 |
0.7 |
|
| 1999 |
Spittaels K, Van den Haute C, Van Dorpe J, Bruynseels K, Vandezande K, Laenen I, Geerts H, Mercken M, Sciot R, Van Lommel A, Loos R, Van Leuven F. Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein. The American Journal of Pathology. 155: 2153-65. PMID 10595944 DOI: 10.1016/S0002-9440(10)65533-2 |
0.401 |
|
| 1999 |
Umans L, Overbergh L, Serneels L, Tesseur I, Van Leuven F. Analysis of expression of genes involved in apolipoprotein E-based lipoprotein metabolism in pregnant mice deficient in the receptor-associated protein, the low density lipoprotein receptor, or apolipoprotein E. Biology of Reproduction. 61: 1216-25. PMID 10529267 DOI: 10.1095/Biolreprod61.5.1216 |
0.692 |
|
| 1999 |
Herreman A, Hartmann D, Annaert W, Saftig P, Craessaerts K, Serneels L, Umans L, Schrijvers V, Checler F, Vanderstichele H, Baekelandt V, Dressel R, Cupers P, Huylebroeck D, Zwijsen A, ... Van Leuven F, et al. Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proceedings of the National Academy of Sciences of the United States of America. 96: 11872-7. PMID 10518543 DOI: 10.1073/Pnas.96.21.11872 |
0.53 |
|
| 1999 |
Lévesque L, Annaert W, Craessaerts K, Mathews PM, Seeger M, Nixon RA, Van Leuven F, Gandy S, Westaway D, St George-Hyslop P, De Strooper B, Fraser PE. Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1. Molecular Medicine (Cambridge, Mass.). 5: 542-54. PMID 10501657 DOI: 10.1007/Bf03401981 |
0.575 |
|
| 1999 |
Umans L, Serneels L, Overbergh L, Stas L, Van Leuven F. alpha2-macroglobulin- and murinoglobulin-1- deficient mice. A mouse model for acute pancreatitis. The American Journal of Pathology. 155: 983-93. PMID 10487856 |
0.304 |
|
| 1999 |
Moechars D, Lorent K, Van Leuven F. Premature death in transgenic mice that overexpress a mutant amyloid precursor protein is preceded by severe neurodegeneration and apoptosis. Neuroscience. 91: 819-30. PMID 10391465 DOI: 10.1016/S0306-4522(98)00599-5 |
0.427 |
|
| 1999 |
Moechars D, Dewachter I, Lorent K, Reversé D, Baekelandt V, Naidu A, Tesseur I, Spittaels K, Haute CV, Checler F, Godaux E, Cordell B, Van Leuven F. Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. The Journal of Biological Chemistry. 274: 6483-92. PMID 10037741 DOI: 10.1074/Jbc.274.10.6483 |
0.736 |
|
| 1999 |
Moechars D, Van Leuven F. Transgenic mice as model for Alzheimer's disease | Genetica transgene muizen als model voor de ziekte van Alzheimer Tijdschrift Voor Geneeskunde. 55: 212-218. DOI: 10.2143/TVG.55.3.1000347 |
0.319 |
|
| 1999 |
Baekelandt V, Moechars D, Laenen I, Lorent K, Van Leuven F. Disturbance of the glutamatergic system in mice transgenic for the amyloid precursor protein Alzheimer's Reports. 2: 359-368. |
0.402 |
|
| 1998 |
Moechars D, Gilis M, Kuipéri C, Laenen I, Van Leuven F. Aggressive behaviour in transgenic mice expressing APP is alleviated by serotonergic drugs. Neuroreport. 9: 3561-4. PMID 9858360 |
0.376 |
|
| 1998 |
Moechars D, Lorent K, Dewachter I, Baekelandt V, De Strooper B, Van Leuven F. Transgenic mice expressing an alpha-secretion mutant of the amyloid precursor protein in the brain develop a progressive CNS disorder. Behavioural Brain Research. 95: 55-64. PMID 9754877 DOI: 10.1016/S0166-4328(97)00210-6 |
0.602 |
|
| 1998 |
De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, Von Figura K, Van Leuven F. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature. 391: 387-90. PMID 9450754 DOI: 10.1038/34910 |
0.554 |
|
| 1997 |
De Strooper B, Beullens M, Contreras B, Levesque L, Craessaerts K, Cordell B, Moechars D, Bollen M, Fraser P, George-Hyslop PS, Van Leuven F. Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins. The Journal of Biological Chemistry. 272: 3590-8. PMID 9013610 DOI: 10.1074/Jbc.272.6.3590 |
0.495 |
|
| 1996 |
De Strooper B, Wu RR, Jaspers M, Van der Schueren B, Vekemans S, Carmeliet G, Van Leuven F, Van Den Oord J, Cassiman JJ. A 68-kD antigen, which is probably an N-terminal fragment of the VLA-5 alpha 5-subunit, is specific for differentiating keratinocytes. Dermatology (Basel, Switzerland). 193: 212-20. PMID 8944343 |
0.456 |
|
| 1996 |
Saftig P, Peters C, von Figura K, Craessaerts K, Van Leuven F, De Strooper B. Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D. The Journal of Biological Chemistry. 271: 27241-4. PMID 8910296 DOI: 10.1074/jbc.271.44.27241 |
0.568 |
|
| 1996 |
Tienari PJ, De Strooper B, Ikonen E, Simons M, Weidemann A, Czech C, Hartmann T, Ida N, Multhaup G, Masters CL, Van Leuven F, Beyreuther K, Dotti CG. The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein. The Embo Journal. 15: 5218-29. PMID 8895567 |
0.504 |
|
| 1996 |
Moechars D, Lorent K, De Strooper B, Dewachter I, Van Leuven F. Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice. The Embo Journal. 15: 1265-74. PMID 8635459 |
0.598 |
|
| 1995 |
De Strooper B, Craessaerts K, Van Leuven F, Van Den Berghe H. Exchanging the extracellular domain of amyloid precursor protein for horseradish peroxidase does not interfere with alpha-secretase cleavage of the beta-amyloid region, but randomizes secretion in Madin-Darby canine kidney cells. The Journal of Biological Chemistry. 270: 30310-4. PMID 8530453 |
0.512 |
|
| 1995 |
De Strooper B, Craessaerts K, Dewachter I, Moechars D, Greenberg B, Van Leuven F, Van den Berghe H. Basolateral secretion of amyloid precursor protein in Madin-Darby canine kidney cells is disturbed by alterations of intracellular pH and by introducing a mutation associated with familial Alzheimer's disease. The Journal of Biological Chemistry. 270: 4058-65. PMID 7876155 |
0.534 |
|
| 1995 |
De Strooper B, Creemers JW, Moechars D, Huylebroeck D, Van De Ven WJ, Van Leuven F, Van den Berghe H. Amyloid precursor protein is not processed by furin, PACE 4, PC1/3, PC2, PC4 and PC5/6 of the furin family of proprotein processing enzymes. Biochimica Et Biophysica Acta. 1246: 185-8. PMID 7819286 |
0.507 |
|
| 1995 |
Van Leuven F, Hilliker C, Serneels L, Umans L, Overbergh L, De Strooper B, Fryns JP, Van den Berghe H. Cloning, characterization, and chromosomal localization to 4p16 of the human gene (LRPAP1) coding for the alpha 2-macroglobulin receptor-associated protein and structural comparison with the murine gene coding for the 44-kDa heparin-binding protein. Genomics. 25: 492-500. PMID 7789983 |
0.423 |
|
| 1995 |
Van Gool D, De Strooper B, Van Leuven F, Dom R. Amyloid precursor protein accumulation in Lewy body dementia and Alzheimer's disease. Dementia (Basel, Switzerland). 6: 63-8. PMID 7606281 |
0.543 |
|
| 1995 |
De Strooper B, Simons M, Multhaup G, Van Leuven F, Beyreuther K, Dotti CG. Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence. The Embo Journal. 14: 4932-8. PMID 7588622 DOI: 10.1002/J.1460-2075.1995.Tb00176.X |
0.589 |
|
| 1995 |
Lorent K, Overbergh L, Moechars D, De Strooper B, Van Leuven F, Van den Berghe H. Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lipase, alpha-2-macroglobulin and the 40,000 molecular weight receptor-associated protein. Neuroscience. 65: 1009-25. PMID 7542371 |
0.527 |
|
| 1994 |
Van Leuven F, Stas L, Hilliker C, Lorent K, Umans L, Serneels L, Overbergh L, Torrekens S, Moechars D, De Strooper B. Structure of the gene (LRP1) coding for the human alpha 2-macroglobulin receptor lipoprotein receptor-related protein. Genomics. 24: 78-89. PMID 7534747 |
0.442 |
|
| 1994 |
Umans L, Serneels L, Hilliker C, Stas L, Overbergh L, De Strooper B, Van Leuven F, Van den Berghe H. Molecular cloning of the mouse gene coding for alpha 2-macroglobulin and targeting of the gene in embryonic stem cells. Genomics. 22: 519-29. PMID 7528166 DOI: 10.1006/geno.1994.1425 |
0.425 |
|
| 1993 |
Van Leuven F, Stas L, Raymakers L, Overbergh L, De Strooper B, Hilliker C, Lorent K, Fias E, Umans L, Torrekens S. Molecular cloning and sequencing of the murine alpha-2-macroglobulin receptor cDNA. Biochimica Et Biophysica Acta. 1173: 71-4. PMID 8485155 |
0.452 |
|
| 1993 |
De Strooper B, Umans L, Van Leuven F, Van Den Berghe H. Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway. The Journal of Cell Biology. 121: 295-304. PMID 8468348 |
0.536 |
|
| 1993 |
Van Gool D, De Strooper B, Van Leuven F, Triau E, Dom R. alpha 2-Macroglobulin expression in neuritic-type plaques in patients with Alzheimer's disease. Neurobiology of Aging. 14: 233-7. PMID 7686641 |
0.492 |
|
| 1993 |
De Strooper B, Van Leuven F. Alpha 2-macroglobulin and subacute-phase responses in Alzheimer's disease. Immunology Today. 14: 143-4. PMID 7682079 |
0.428 |
|
| 1993 |
Jaspers M, Vekemans S, Carmeliet G, van Leuven F, de Strooper B, Deckmyn H, Cassiman JJ. A monoclonal antibody to the alpha 2 integrin subunit cross-reacts with RGD-dependent epitopes in fibrinogen. Hybridoma. 12: 467-74. PMID 7503943 |
0.415 |
|
| 1992 |
Delabie J, Shipman R, Brüggen J, De Strooper B, van Leuven F, Tarcsay L, Cerletti N, Odink K, Diehl V, Bilbe G. Expression of the novel intermediate filament-associated protein restin in Hodgkin's disease and anaplastic large-cell lymphoma. Blood. 80: 2891-6. PMID 1450414 |
0.445 |
|
| 1992 |
De Strooper B, Van Leuven F, Van den Berghe H. Alpha 2-macroglobulin and other proteinase inhibitors do not interfere with the secretion of amyloid precursor protein in mouse neuroblastoma cells. Febs Letters. 308: 50-3. PMID 1379551 |
0.49 |
|
| 1992 |
van Leuven F, Torrekens S, Overbergh L, Lorent K, de Strooper B, van den Berghe H. The primary sequence and the subunit structure of mouse alpha-2-macroglobulin, deduced from protein sequencing of the isolated subunits and from molecular cloning of the cDNA. European Journal of Biochemistry / Febs. 210: 319-27. PMID 1280217 |
0.422 |
|
| 1991 |
De Strooper B, Van Leuven F, Carmeliet G, Van Den Berghe H, Cassiman JJ. Cultured human fibroblasts contain a large pool of precursor beta 1-integrin but lack an intracellular pool of mature subunit. European Journal of Biochemistry / Febs. 199: 25-33. PMID 1906002 |
0.455 |
|
| 1991 |
De Strooper B, Van Leuven F, Van den Berghe H. The amyloid beta protein precursor or proteinase nexin II from mouse is closer related to its human homolog than previously reported. Biochimica Et Biophysica Acta. 1129: 141-3. PMID 1756177 |
0.522 |
|
| 1989 |
De Strooper B, Van der Schueren B, Jaspers M, Saison M, Spaepen M, Van Leuven F, Van den Berghe H, Cassiman JJ. Distribution of the beta 1 subgroup of the integrins in human cells and tissues. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 37: 299-307. PMID 2645360 |
0.434 |
|
| 1988 |
De Strooper B, Saison M, Jaspers M, Spaepen M, Van Leuven F, Van den Berghe H, Cassiman JJ. Monoclonal antibody DH12 reacts with a cell surface and a precursor form of the beta subunit of the human fibronectin receptor. Cell Biology International Reports. 12: 9-16. PMID 2969294 |
0.458 |
|
| 1988 |
Jaspers M, de Strooper B, Spaepen M, van Leuven F, David G, van den Berghe H, Cassiman JJ. Post-translational modification of the beta-subunit of the human fibronectin receptor. Febs Letters. 231: 402-6. PMID 2966078 DOI: 10.1016/0014-5793(88)80859-7 |
0.465 |
|
| 1988 |
Zhang Y, Saison M, Spaepen M, De Strooper B, Van Leuven F, David G, Van den Berghe H, Cassiman JJ. Mapping of human fibronectin receptor beta subunit gene to chromosome 10. Somatic Cell and Molecular Genetics. 14: 99-104. PMID 2963381 |
0.458 |
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