Year |
Citation |
Score |
2024 |
Hruska-Plochan M, Wiersma VI, Betz KM, Mallona I, Ronchi S, Maniecka Z, Hock EM, Tantardini E, Laferriere F, Sahadevan S, Hoop V, Delvendahl I, Pérez-Berlanga M, Gatta B, Panatta M, ... ... Lashley T, et al. A model of human neural networks reveals NPTX2 pathology in ALS and FTLD. Nature. PMID 38355792 DOI: 10.1038/s41586-024-07042-7 |
0.324 |
|
2024 |
Luo H, Gustavsson EK, Macpherson H, Dominik N, Zhelcheska K, Montgomery K, Anderson C, Yau WY, Efthymiou S, Turner C, DeTure M, Dickson DW, Josephs KA, Revesz T, Lashley T, et al. Letter to the editor on: Hornerin deposits in neuronal intranuclear inclusion disease: direct identification of proteins with compositionally biased regions in inclusions by Park et al. (2022). Acta Neuropathologica Communications. 12: 2. PMID 38167323 DOI: 10.1186/s40478-023-01706-7 |
0.351 |
|
2023 |
Tetter S, Arseni D, Murzin AG, Buhidma Y, Peak-Chew SY, Garringer HJ, Newell KL, Vidal R, Apostolova LG, Lashley T, Ghetti B, Ryskeldi-Falcon B. TAF15 amyloid filaments in frontotemporal lobar degeneration. Nature. PMID 38057661 DOI: 10.1038/s41586-023-06801-2 |
0.33 |
|
2023 |
Arber C, Casey JM, Crawford S, Rambarack N, Yaman U, Wiethoff S, Augustin E, Piers TM, Rostagno A, Ghiso J, Lewis PA, Revesz T, Hardy J, Pocock JM, Houlden H, ... ... Lashley T, et al. Microglia produce the amyloidogenic ABri peptide in familial British dementia. Biorxiv : the Preprint Server For Biology. PMID 37425748 DOI: 10.1101/2023.06.27.546552 |
0.352 |
|
2023 |
Jiang X, Gatt A, Lashley T. HnRNP Pathologies in Frontotemporal Lobar Degeneration. Cells. 12. PMID 37371103 DOI: 10.3390/cells12121633 |
0.371 |
|
2023 |
Fodder K, Murthy M, Rizzu P, Toomey CE, Hasan R, Humphrey J, Raj T, Lunnon K, Mill J, Heutink P, Lashley T, Bettencourt C. Brain DNA methylomic analysis of frontotemporal lobar degeneration reveals OTUD4 in shared dysregulated signatures across pathological subtypes. Acta Neuropathologica. PMID 37149835 DOI: 10.1007/s00401-023-02583-z |
0.701 |
|
2022 |
Brown AL, Wilkins OG, Keuss MJ, Hill SE, Zanovello M, Lee WC, Bampton A, Lee FCY, Masino L, Qi YA, Bryce-Smith S, Gatt A, Hallegger M, Fagegaltier D, Phatnani H, ... ... Lashley T, et al. TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A. Nature. PMID 35197628 DOI: 10.1038/s41586-022-04436-3 |
0.715 |
|
2022 |
Sidhu R, Gatt A, Fratta P, Lashley T, Bampton A. HnRNP K mislocalisation in neurons of the dentate nucleus is a novel neuropathological feature of neurodegenerative disease and ageing. Neuropathology and Applied Neurobiology. PMID 35064577 DOI: 10.1111/nan.12793 |
0.34 |
|
2021 |
Hasan R, Humphrey J, Bettencourt C, Newcombe J, Lashley T, Fratta P, Raj T. Transcriptomic analysis of frontotemporal lobar degeneration with TDP-43 pathology reveals cellular alterations across multiple brain regions. Acta Neuropathologica. PMID 34961893 DOI: 10.1007/s00401-021-02399-9 |
0.727 |
|
2021 |
Stepanchuk AA, Barber PA, Lashley T, Joseph JT, Stys PK. Quantitative detection of grey and white matter amyloid pathology using a combination of K114 and CRANAD-3 fluorescence. Neurobiology of Disease. 161: 105540. PMID 34751140 DOI: 10.1016/j.nbd.2021.105540 |
0.317 |
|
2021 |
Lashley T, Tossounian MA, Costello Heaven N, Wallworth S, Peak-Chew S, Bradshaw A, Cooper JM, de Silva R, Srai SK, Malanchuk O, Filonenko V, Koopman MB, Rüdiger SGD, Skehel M, Gout I. Extensive Anti-CoA Immunostaining in Alzheimer's Disease and Covalent Modification of Tau by a Key Cellular Metabolite Coenzyme A. Frontiers in Cellular Neuroscience. 15: 739425. PMID 34720880 DOI: 10.3389/fncel.2021.739425 |
0.322 |
|
2021 |
Bampton A, Gatt A, Humphrey J, Cappelli S, Bhattacharya D, Foti S, Brown AL, Asi Y, Low YH, Foiani M, Raj T, Buratti E, Fratta P, Lashley T. HnRNP K mislocalisation is a novel protein pathology of frontotemporal lobar degeneration and ageing and leads to cryptic splicing. Acta Neuropathologica. PMID 34274995 DOI: 10.1007/s00401-021-02340-0 |
0.691 |
|
2020 |
Quaegebeur A, Glaria I, Lashley T, Isaacs AM. Soluble and insoluble dipeptide repeat protein measurements in C9orf72-frontotemporal dementia brains show regional differential solubility and correlation of poly-GR with clinical severity. Acta Neuropathologica Communications. 8: 184. PMID 33168090 DOI: 10.1186/s40478-020-01036-y |
0.645 |
|
2020 |
Low YH, Asi Y, Foti SC, Lashley T. Heterogeneous Nuclear Ribonucleoproteins: Implications in Neurological Diseases. Molecular Neurobiology. PMID 33000450 DOI: 10.1007/s12035-020-02137-4 |
0.396 |
|
2020 |
Prudencio M, Humphrey J, Pickles S, Brown AL, Hill SE, Kachergus J, Shi J, Heckman M, Spiegel M, Cook C, Song Y, Yue M, Daughrity L, Carlomagno Y, Jansen-West K, ... ... Lashley T, et al. Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia. The Journal of Clinical Investigation. PMID 32790644 DOI: 10.1172/Jci139741 |
0.747 |
|
2020 |
Chen Z, Yan Yau W, Jaunmuktane Z, Tucci A, Sivakumar P, Gagliano Taliun SA, Turner C, Efthymiou S, Ibáñez K, Sullivan R, Bibi F, Athanasiou-Fragkouli A, Bourinaris T, Zhang D, Revesz T, ... Lashley T, et al. Neuronal intranuclear inclusion disease is genetically heterogeneous. Annals of Clinical and Translational Neurology. PMID 32777174 DOI: 10.1002/Acn3.51151 |
0.311 |
|
2020 |
Bampton A, Gittings LM, Fratta P, Lashley T, Gatt A. The role of hnRNPs in frontotemporal dementia and amyotrophic lateral sclerosis. Acta Neuropathologica. PMID 32748079 DOI: 10.1007/s00401-020-02203-0 |
0.77 |
|
2020 |
Orme T, Hernandez D, Ross OA, Kun-Rodrigues C, Darwent L, Shepherd CE, Parkkinen L, Ansorge O, Clark L, Honig LS, Marder K, Lemstra A, Rogaeva E, St George-Hyslop P, Londos E, ... ... Lashley T, et al. Analysis of neurodegenerative disease-causing genes in dementia with Lewy bodies. Acta Neuropathologica Communications. 8: 5. PMID 31996268 DOI: 10.1186/S40478-020-0879-Z |
0.312 |
|
2019 |
Gittings LM, Boeynaems S, Lightwood D, Clargo A, Topia S, Nakayama L, Troakes C, Mann DMA, Gitler AD, Lashley T, Isaacs AM. Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR phase separation and toxicity. Acta Neuropathologica. PMID 31832771 DOI: 10.1007/S00401-019-02104-X |
0.711 |
|
2019 |
Lamb R, Rohrer JD, Real R, Lubbe SJ, Waite AJ, Blake DJ, Walters RJ, Lashley T, Revesz T, Holton JL, Morris HR. A novel mutation in a family with diverse frontotemporal dementia spectrum disorders. Cold Spring Harbor Molecular Case Studies. 5. PMID 31160356 DOI: 10.1101/mcs.a003913 |
0.315 |
|
2019 |
Gittings LM, Foti SC, Benson BC, Gami-Patel P, Isaacs AM, Lashley T. Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUS. Acta Neuropathologica Communications. 7: 18. PMID 30755280 DOI: 10.1186/s40478-019-0673-y |
0.729 |
|
2019 |
Laferrière F, Maniecka Z, Pérez-Berlanga M, Hruska-Plochan M, Gilhespy L, Hock EM, Wagner U, Afroz T, Boersema PJ, Barmettler G, Foti SC, Asi YT, Isaacs AM, Al-Amoudi A, Lewis A, ... ... Lashley T, et al. TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates. Nature Neuroscience. 22: 65-77. PMID 30559480 DOI: 10.1038/S41593-018-0294-Y |
0.676 |
|
2018 |
Hock EM, Maniecka Z, Hruska-Plochan M, Reber S, Laferrière F, Sahadevan M K S, Ederle H, Gittings L, Pelkmans L, Dupuis L, Lashley T, Ruepp MD, Dormann D, Polymenidou M. Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function. Cell Reports. 24: 987-1000.e7. PMID 30044993 DOI: 10.1016/J.Celrep.2018.06.094 |
0.746 |
|
2018 |
Mokretar K, Pease D, Taanman JW, Soenmez A, Ejaz A, Lashley T, Ling H, Gentleman S, Houlden H, Holton JL, Schapira AHV, Nacheva E, Proukakis C. Somatic copy number gains of α-synuclein (SNCA) in Parkinson's disease and multiple system atrophy brains. Brain : a Journal of Neurology. PMID 29917054 DOI: 10.1093/brain/awy157 |
0.32 |
|
2018 |
Lashley T, Schott JM, Weston P, Murray CE, Wellington H, Keshavan A, Foti SC, Foiani M, Toombs J, Rohrer JD, Heslegrave A, Zetterberg H. Molecular biomarkers of Alzheimer's disease: progress and prospects. Disease Models & Mechanisms. 11. PMID 29739861 DOI: 10.1242/dmm.031781 |
0.324 |
|
2017 |
Weil RS, Lashley TL, Bras J, Schrag AE, Schott JM. Current concepts and controversies in the pathogenesis of Parkinson's disease dementia and Dementia with Lewy Bodies. F1000research. 6: 1604. PMID 28928962 DOI: 10.12688/f1000research.11725.1 |
0.345 |
|
2017 |
Davidson YS, Robinson AC, Flood L, Rollinson S, Benson BC, Asi YT, Richardson A, Jones M, Snowden JS, Pickering-Brown S, Lashley T, Mann DMA. Heterogeneous ribonuclear protein E2 (hnRNP E2) is associated with TDP-43-immunoreactive neurites in Semantic Dementia but not with other TDP-43 pathological subtypes of Frontotemporal Lobar Degeneration. Acta Neuropathologica Communications. 5: 54. PMID 28666471 DOI: 10.1186/S40478-017-0454-4 |
0.321 |
|
2017 |
Mizielinska S, Ridler CE, Balendra R, Thoeng A, Woodling NS, Grässer FA, Plagnol V, Lashley T, Partridge L, Isaacs AM. Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration. Acta Neuropathologica Communications. 5: 29. PMID 28420437 DOI: 10.1186/S40478-017-0432-X |
0.699 |
|
2016 |
Gami-Patel P, Bandopadhyay R, Brelstaff J, Revesz T, Lashley T. The presence of heterogeneous nuclear ribonucleoproteins in frontotemporal lobar degeneration with FUS-positive inclusions. Neurobiology of Aging. 46: 192-203. PMID 27500866 DOI: 10.1016/j.neurobiolaging.2016.07.004 |
0.336 |
|
2015 |
Gami P, Murray C, Schottlaender L, Bettencourt C, De Pablo Fernandez E, Mudanohwo E, Mizielinska S, Polke JM, Holton JL, Isaacs AM, Houlden H, Revesz T, Lashley T. A 30-unit hexanucleotide repeat expansion in C9orf72 induces pathological lesions with dipeptide-repeat proteins and RNA foci, but not TDP-43 inclusions and clinical disease. Acta Neuropathologica. 130: 599-601. PMID 26347457 DOI: 10.1007/S00401-015-1473-5 |
0.669 |
|
2015 |
Clark CN, Lashley T, Mahoney CJ, Warren JD, Revesz T, Rohrer JD. Temporal Variant Frontotemporal Dementia Is Associated with Globular Glial Tauopathy. Cognitive and Behavioral Neurology : Official Journal of the Society For Behavioral and Cognitive Neurology. 28: 92-7. PMID 26102999 DOI: 10.1097/WNN.0000000000000060 |
0.305 |
|
2015 |
Lashley T, Rohrer JD, Mead S, Revesz T. Review: an update on clinical, genetic and pathological aspects of frontotemporal lobar degenerations. Neuropathology and Applied Neurobiology. 41: 858-81. PMID 26041104 DOI: 10.1111/nan.12250 |
0.334 |
|
2015 |
Rohrer JD, Isaacs AM, Mizielinska S, Mead S, Lashley T, Wray S, Sidle K, Fratta P, Orrell RW, Hardy J, Holton J, Revesz T, Rossor MN, Warren JD. C9orf72 expansions in frontotemporal dementia and amyotrophic lateral sclerosis. The Lancet. Neurology. 14: 291-301. PMID 25638642 DOI: 10.1016/S1474-4422(14)70233-9 |
0.707 |
|
2015 |
Fratta P, Polke JM, Newcombe J, Mizielinska S, Lashley T, Poulter M, Beck J, Preza E, Devoy A, Sidle K, Howard R, Malaspina A, Orrell RW, Clarke J, Lu CH, et al. Screening a UK amyotrophic lateral sclerosis cohort provides evidence of multiple origins of the C9orf72 expansion. Neurobiology of Aging. 36: 546.e1-7. PMID 25179228 DOI: 10.1016/J.Neurobiolaging.2014.07.037 |
0.647 |
|
2014 |
Cortese A, Plagnol V, Brady S, Simone R, Lashley T, Acevedo-Arozena A, de Silva R, Greensmith L, Holton J, Hanna MG, Fisher EM, Fratta P. Widespread RNA metabolism impairment in sporadic inclusion body myositis TDP43-proteinopathy. Neurobiology of Aging. 35: 1491-8. PMID 24462217 DOI: 10.1016/J.Neurobiolaging.2013.12.029 |
0.36 |
|
2014 |
Iovino M, Pfisterer U, Holton JL, Lashley T, Swingler RJ, Calo L, Treacy R, Revesz T, Parmar M, Goedert M, Muqit MM, Spillantini MG. The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons. Acta Neuropathologica. 127: 283-95. PMID 24292008 DOI: 10.1007/S00401-013-1219-1 |
0.325 |
|
2013 |
Mead S, Gandhi S, Beck J, Caine D, Gajulapalli D, Gallujipali D, Carswell C, Hyare H, Joiner S, Ayling H, Lashley T, Linehan JM, Al-Doujaily H, Sharps B, Revesz T, et al. A novel prion disease associated with diarrhea and autonomic neuropathy. The New England Journal of Medicine. 369: 1904-14. PMID 24224623 DOI: 10.1056/Nejmoa1214747 |
0.341 |
|
2013 |
Mizielinska S, Lashley T, Norona FE, Clayton EL, Ridler CE, Fratta P, Isaacs AM. C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci. Acta Neuropathologica. 126: 845-57. PMID 24170096 DOI: 10.1007/S00401-013-1200-Z |
0.671 |
|
2013 |
Cooper-Knock J, Frolov A, Highley JR, Charlesworth G, Kirby J, Milano A, Hartley J, Ince PG, McDermott CJ, Lashley T, Revesz T, Shaw PJ, Wood NW, Bandmann O. C9ORF72 expansions, parkinsonism, and Parkinson disease: a clinicopathologic study. Neurology. 81: 808-11. PMID 23884045 DOI: 10.1212/WNL.0b013e3182a2cc38 |
0.315 |
|
2013 |
Fratta P, Poulter M, Lashley T, Rohrer JD, Polke JM, Beck J, Ryan N, Hensman D, Mizielinska S, Waite AJ, Lai MC, Gendron TF, Petrucelli L, Fisher EM, Revesz T, et al. Homozygosity for the C9orf72 GGGGCC repeat expansion in frontotemporal dementia. Acta Neuropathologica. 126: 401-9. PMID 23818065 DOI: 10.1007/S00401-013-1147-0 |
0.687 |
|
2013 |
Lashley T, Hardy J, Isaacs AM. RANTing about C9orf72. Neuron. 77: 597-8. PMID 23439112 DOI: 10.1016/J.Neuron.2013.02.009 |
0.682 |
|
2012 |
Mahoney CJ, Beck J, Rohrer JD, Lashley T, Mok K, Shakespeare T, Yeatman T, Warrington EK, Schott JM, Fox NC, Rossor MN, Hardy J, Collinge J, Revesz T, Mead S, et al. Frontotemporal dementia with the C9ORF72 hexanucleotide repeat expansion: clinical, neuroanatomical and neuropathological features. Brain : a Journal of Neurology. 135: 736-50. PMID 22366791 DOI: 10.1093/Brain/Awr361 |
0.333 |
|
2011 |
Rohrer JD, Lashley T, Schott JM, Warren JE, Mead S, Isaacs AM, Beck J, Hardy J, de Silva R, Warrington E, Troakes C, Al-Sarraj S, King A, Borroni B, Clarkson MJ, et al. Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration. Brain : a Journal of Neurology. 134: 2565-81. PMID 21908872 DOI: 10.1093/Brain/Awr198 |
0.657 |
|
2011 |
Brelstaff J, Lashley T, Holton JL, Lees AJ, Rossor MN, Bandopadhyay R, Revesz T. Transportin1: a marker of FTLD-FUS. Acta Neuropathologica. 122: 591-600. PMID 21847626 DOI: 10.1007/S00401-011-0863-6 |
0.369 |
|
2011 |
Ahmed Z, Doherty KM, Silveira-Moriyama L, Bandopadhyay R, Lashley T, Mamais A, Hondhamuni G, Wray S, Newcombe J, O'Sullivan SS, Wroe S, de Silva R, Holton JL, Lees AJ, Revesz T. Globular glial tauopathies (GGT) presenting with motor neuron disease or frontotemporal dementia: an emerging group of 4-repeat tauopathies. Acta Neuropathologica. 122: 415-28. PMID 21773886 DOI: 10.1007/S00401-011-0857-4 |
0.335 |
|
2011 |
Lashley T, Rohrer JD, Bandopadhyay R, Fry C, Ahmed Z, Isaacs AM, Brelstaff JH, Borroni B, Warren JD, Troakes C, King A, Al-Saraj S, Newcombe J, Quinn N, Ostergaard K, et al. A comparative clinical, pathological, biochemical and genetic study of fused in sarcoma proteinopathies. Brain : a Journal of Neurology. 134: 2548-64. PMID 21752791 DOI: 10.1093/Brain/Awr160 |
0.666 |
|
2011 |
Rohrer JD, Lashley T, Holton J, Revesz T, Urwin H, Isaacs AM, Fox NC, Rossor MN, Warren J. The clinical and neuroanatomical phenotype of FUS associated frontotemporal lobar degeneration. Journal of Neurology, Neurosurgery, and Psychiatry. 82: 1405-7. PMID 20639383 DOI: 10.1136/Jnnp.2010.214437 |
0.663 |
|
2007 |
Kumaran R, Kingsbury A, Coulter I, Lashley T, Williams D, de Silva R, Mann D, Revesz T, Lees A, Bandopadhyay R. DJ-1 (PARK7) is associated with 3R and 4R tau neuronal and glial inclusions in neurodegenerative disorders. Neurobiology of Disease. 28: 122-32. PMID 17719794 DOI: 10.1016/J.Nbd.2007.07.012 |
0.305 |
|
2005 |
Piao YS, Tan CF, Iwanaga K, Kakita A, Takano H, Nishizawa M, Lashley T, Revesz T, Lees A, de Silva R, Tsujihata M, Takahashi H. Sporadic four-repeat tauopathy with frontotemporal degeneration, parkinsonism and motor neuron disease. Acta Neuropathologica. 110: 600-9. PMID 16328530 DOI: 10.1007/s00401-005-1086-5 |
0.33 |
|
2004 |
Bandopadhyay R, Kingsbury AE, Cookson MR, Reid AR, Evans IM, Hope AD, Pittman AM, Lashley T, Canet-Aviles R, Miller DW, McLendon C, Strand C, Leonard AJ, Abou-Sleiman PM, Healy DG, et al. The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease. Brain : a Journal of Neurology. 127: 420-30. PMID 14662519 DOI: 10.1093/Brain/Awh054 |
0.31 |
|
Low-probability matches (unlikely to be authored by this person) |
2023 |
Valentino RR, Scotton WJ, Roemer SF, Lashley T, Heckman MG, Shoai M, Martinez-Carrasco A, Tamvaka N, Walton RL, Baker MC, Macpherson HL, Real R, Soto-Beasley AI, Mok K, Revesz T, et al. Creating the Pick's disease International Consortium: Association study of H2 haplotype with risk of Pick's disease. Medrxiv : the Preprint Server For Health Sciences. PMID 37163045 DOI: 10.1101/2023.04.17.23288471 |
0.298 |
|
2021 |
Yap SY, Frias B, Wren MC, Schöll M, Fox NC, Årstad E, Lashley T, Sander K. Discriminatory ability of next-generation tau PET tracers for Alzheimer's disease. Brain : a Journal of Neurology. PMID 33742656 DOI: 10.1093/brain/awab120 |
0.291 |
|
2009 |
Revesz T, Holton JL, Lashley T, Plant G, Frangione B, Rostagno A, Ghiso J. Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies. Acta Neuropathologica. 118: 115-30. PMID 19225789 DOI: 10.1007/S00401-009-0501-8 |
0.29 |
|
2018 |
Murray CE, Gami-Patel P, Gkanatsiou E, Brinkmalm G, Portelius E, Wirths O, Heywood W, Blennow K, Ghiso J, Holton JL, Mills K, Zetterberg H, Revesz T, Lashley T. The presubiculum is preserved from neurodegenerative changes in Alzheimer's disease. Acta Neuropathologica Communications. 6: 62. PMID 30029687 DOI: 10.1186/S40478-018-0563-8 |
0.289 |
|
2021 |
Shi Y, Zhang W, Yang Y, Murzin AG, Falcon B, Kotecha A, van Beers M, Tarutani A, Kametani F, Garringer HJ, Vidal R, Hallinan GI, Lashley T, Saito Y, Murayama S, et al. Structure-based classification of tauopathies. Nature. PMID 34588692 DOI: 10.1038/s41586-021-03911-7 |
0.287 |
|
2014 |
Paudel R, Kiely A, Li A, Lashley T, Bandopadhyay R, Hardy J, Jinnah HA, Bhatia K, Houlden H, Holton JL. Neuropathological features of genetically confirmed DYT1 dystonia: investigating disease-specific inclusions. Acta Neuropathologica Communications. 2: 159. PMID 25403864 DOI: 10.1186/S40478-014-0159-X |
0.286 |
|
2014 |
Compta Y, Parkkinen L, Kempster P, Selikhova M, Lashley T, Holton JL, Lees AJ, Revesz T. The significance of α-synuclein, amyloid-β and tau pathologies in Parkinson's disease progression and related dementia. Neuro-Degenerative Diseases. 13: 154-6. PMID 24028925 DOI: 10.1159/000354670 |
0.286 |
|
2009 |
Davidson Y, Amin H, Kelley T, Shi J, Tian J, Kumaran R, Lashley T, Lees AJ, DuPlessis D, Neary D, Snowden J, Akiyama H, Arai T, Hasegawa M, Bandopadhyay R, et al. TDP-43 in ubiquitinated inclusions in the inferior olives in frontotemporal lobar degeneration and in other neurodegenerative diseases: a degenerative process distinct from normal ageing. Acta Neuropathologica. 118: 359-69. PMID 19330339 DOI: 10.1007/S00401-009-0526-Z |
0.285 |
|
2016 |
Kun-Rodrigues C, Ross OA, Orme T, Shepherd C, Parkkinen L, Darwent L, Hernandez D, Ansorge O, Clark LN, Honig LS, Marder K, Lemstra A, Scheltens P, van der Flier W, Louwersheimer E, ... ... Lashley T, et al. Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies. Neurobiology of Aging. PMID 27666590 DOI: 10.1016/J.Neurobiolaging.2016.08.023 |
0.278 |
|
2022 |
Mehta PR, Lashley T, Fratta P, Bampton A. Markers of cognitive resilience and a framework for investigating clinical heterogeneity in ALS. The Journal of Pathology. PMID 35342958 DOI: 10.1002/path.5897 |
0.274 |
|
2014 |
Lashley T, Rohrer JD, Mahoney C, Gordon E, Beck J, Mead S, Warren J, Rossor M, Revesz T. A pathogenic progranulin mutation and C9orf72 repeat expansion in a family with frontotemporal dementia. Neuropathology and Applied Neurobiology. 40: 502-13. PMID 24286341 DOI: 10.1111/Nan.12100 |
0.273 |
|
2006 |
de Silva R, Lashley T, Strand C, Shiarli AM, Shi J, Tian J, Bailey KL, Davies P, Bigio EH, Arima K, Iseki E, Murayama S, Kretzschmar H, Neumann M, Lippa C, et al. An immunohistochemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R- and 4R-specific tau monoclonal antibodies. Acta Neuropathologica. 111: 329-40. PMID 16552612 DOI: 10.1007/S00401-006-0048-X |
0.272 |
|
2021 |
De Rossi P, Lewis AJ, Furrer J, De Vos L, Demeter T, Zbinden A, Zhong W, Wiersma VI, Scialo C, Weber J, Guo Z, Scaramuzza S, Di Fabrizio M, Böing C, Castaño-Díez D, ... ... Lashley T, et al. FTLD-TDP assemblies seed neoaggregates with subtype-specific features via a prion-like cascade. Embo Reports. 22: e53877. PMID 34806807 DOI: 10.15252/embr.202153877 |
0.271 |
|
2003 |
Revesz T, Ghiso J, Lashley T, Plant G, Rostagno A, Frangione B, Holton JL. Cerebral amyloid angiopathies: a pathologic, biochemical, and genetic view. Journal of Neuropathology and Experimental Neurology. 62: 885-98. PMID 14533778 DOI: 10.1093/Jnen/62.9.885 |
0.271 |
|
2015 |
Szaruga M, Veugelen S, Benurwar M, Lismont S, Sepulveda-Falla D, Lleo A, Ryan NS, Lashley T, Fox NC, Murayama S, Gijsen H, De Strooper B, Chávez-Gutiérrez L. Qualitative changes in human γ-secretase underlie familial Alzheimer's disease. The Journal of Experimental Medicine. PMID 26481686 DOI: 10.1084/Jem.20150892 |
0.267 |
|
2013 |
Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, et al. TREM2 variants in Alzheimer's disease. The New England Journal of Medicine. 368: 117-27. PMID 23150934 DOI: 10.1056/Nejmoa1211851 |
0.266 |
|
2021 |
Rostagno A, Calero M, Holton JL, Revesz T, Lashley T, Ghiso J. Association of clusterin with the BRI2-derived amyloid molecules ABri and ADan. Neurobiology of Disease. 158: 105452. PMID 34298087 DOI: 10.1016/j.nbd.2021.105452 |
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Wren MC, Lashley T, Årstad E, Sander K. Large inter- and intra-case variability of first generation tau PET ligand binding in neurodegenerative dementias. Acta Neuropathologica Communications. 6: 34. PMID 29716656 DOI: 10.1186/s40478-018-0535-z |
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Toomey CE, Heywood W, Benson BC, Packham G, Mills K, Lashley T. Investigation of pathology, expression and proteomic profiles in human TREM2 variant post-mortem brains with and without Alzheimer's disease. Brain Pathology (Zurich, Switzerland). PMID 32267026 DOI: 10.1111/bpa.12842 |
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Ryan NS, Nicholas JM, Weston PS, Liang Y, Lashley T, Guerreiro R, Adamson G, Kenny J, Beck J, Chavez-Gutierrez L, de Strooper B, Revesz T, Holton J, Mead S, Rossor MN, et al. Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer's disease: a case series. The Lancet. Neurology. PMID 27777022 DOI: 10.1016/S1474-4422(16)30193-4 |
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Zhang F, Rakhimbekova A, Lashley T, Madl T. Brain regions show different metabolic and protein arginine methylation phenotypes in frontotemporal dementias and Alzheimer's disease. Progress in Neurobiology. 221: 102400. PMID 36581185 DOI: 10.1016/j.pneurobio.2022.102400 |
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Bras J, Guerreiro R, Darwent L, Parkkinen L, Ansorge O, Escott-Price V, Hernandez DG, Nalls MA, Clark LN, Honig LS, Marder K, Van Der Flier WM, Lemstra A, Scheltens P, Rogaeva E, ... ... Lashley T, et al. Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies. Human Molecular Genetics. 23: 6139-46. PMID 24973356 DOI: 10.1093/Hmg/Ddu334 |
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Cummings DM, Benway TA, Ho H, Tedoldi A, Fernandes Freitas MM, Shahab L, Murray CE, Richard-Loendt A, Brandner S, Lashley T, Salih DA, Edwards FA. Neuronal and Peripheral Pentraxins Modify Glutamate Release and may Interact in Blood-Brain Barrier Failure. Cerebral Cortex (New York, N.Y. : 1991). 1-12. PMID 28334103 DOI: 10.1093/Cercor/Bhx046 |
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Perez-Rodriguez D, Kalyva M, Leija-Salazar M, Lashley T, Tarabichi M, Chelban V, Gentleman S, Schottlaender L, Franklin H, Vasmatzis G, Houlden H, Schapira AHV, Warner TT, Holton JL, Jaunmuktane Z, et al. Investigation of somatic CNVs in brains of synucleinopathy cases using targeted SNCA analysis and single cell sequencing. Acta Neuropathologica Communications. 7: 219. PMID 31870437 DOI: 10.1186/S40478-019-0873-5 |
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Blennow K, Chen C, Cicognola C, Wildsmith KR, Manser PT, Bohorquez SMS, Zhang Z, Xie B, Peng J, Hansson O, Kvartsberg H, Portelius E, Zetterberg H, Lashley T, Brinkmalm G, et al. Cerebrospinal fluid tau fragment correlates with tau PET: a candidate biomarker for tangle pathology. Brain : a Journal of Neurology. PMID 31834365 DOI: 10.1093/Brain/Awz346 |
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Willumsen N, Poole T, Nicholas JM, Fox NC, Ryan NS, Lashley T. Variability in the type and layer distribution of cortical Aβ pathology in familial Alzheimer's disease. Brain Pathology (Zurich, Switzerland). e13009. PMID 34319632 DOI: 10.1111/bpa.13009 |
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Kun-Rodrigues C, Orme T, Carmona S, Hernandez DG, Ross OA, Eicher JD, Shepherd C, Parkkinen L, Darwent L, Heckman MG, Scholz SW, Troncoso JC, Pletnikova O, Dawson T, Rosenthal L, ... ... Lashley T, et al. A comprehensive screening of copy number variability in dementia with Lewy bodies. Neurobiology of Aging. PMID 30448004 DOI: 10.1016/J.Neurobiolaging.2018.10.019 |
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Schweighauser M, Arseni D, Bacioglu M, Huang M, Lövestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, ... ... Lashley T, et al. Age-dependent formation of TMEM106B amyloid filaments in human brains. Nature. PMID 35344985 DOI: 10.1038/s41586-022-04650-z |
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Huang Y, Song YJ, Murphy K, Holton JL, Lashley T, Revesz T, Gai WP, Halliday GM. LRRK2 and parkin immunoreactivity in multiple system atrophy inclusions. Acta Neuropathologica. 116: 639-46. PMID 18936941 DOI: 10.1007/s00401-008-0446-3 |
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Arber C, Toombs J, Lovejoy CC, Ryan NS, Paterson RW, Willumsen N, Gkanatsiou E, Portelius E, Blennow K, Heslegrave A, Schott JM, Hardy J, Lashley T, Fox NC, Zetterberg H, et al. Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta. Molecular Psychiatry. PMID 30980041 DOI: 10.1038/S41380-019-0410-8 |
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Bettencourt C, Foti SC, Miki Y, Botia J, Chatterjee A, Warner TT, Revesz T, Lashley T, Balazs R, Viré E, Holton JL. White matter DNA methylation profiling reveals deregulation of HIP1, LMAN2, MOBP, and other loci in multiple system atrophy. Acta Neuropathologica. PMID 31535203 DOI: 10.1007/s00401-019-02074-0 |
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Rostagno A, Revesz T, Lashley T, Tomidokoro Y, Magnotti L, Braendgaard H, Plant G, Bojsen-Møller M, Holton J, Frangione B, Ghiso J. Complement activation in chromosome 13 dementias. Similarities with Alzheimer's disease. The Journal of Biological Chemistry. 277: 49782-90. PMID 12388551 DOI: 10.1074/Jbc.M206448200 |
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Compta Y, Parkkinen L, O'Sullivan SS, Vandrovcova J, Holton JL, Collins C, Lashley T, Kallis C, Williams DR, de Silva R, Lees AJ, Revesz T. Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important? Brain : a Journal of Neurology. 134: 1493-505. PMID 21596773 DOI: 10.1093/Brain/Awr031 |
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Momeni P, Pittman A, Lashley T, Vandrovcova J, Malzer E, Luk C, Hulette C, Lees A, Revesz T, Hardy J, de Silva R. Clinical and pathological features of an Alzheimer's disease patient with the MAPT Delta K280 mutation. Neurobiology of Aging. 30: 388-93. PMID 17723255 DOI: 10.1016/J.Neurobiolaging.2007.07.013 |
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Koriath C, Lashley T, Taylor W, Druyeh R, Dimitriadis A, Denning N, Williams J, Warren JD, Fox NC, Schott JM, Rowe JB, Collinge J, Rohrer JD, Mead S. ApoE4 lowers age at onset in patients with frontotemporal dementia and tauopathy independent of amyloid-β copathology. Alzheimer's & Dementia (Amsterdam, Netherlands). 11: 277-280. PMID 30949567 DOI: 10.1016/J.Dadm.2019.01.010 |
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Koutarapu S, Ge J, Jha D, Blennow K, Zetterberg H, Lashley T, Michno W, Hanrieder J. Correlative chemical imaging identifies amyloid peptide signatures of neuritic plaques and dystrophy in human sporadic Alzheimer's disease. Brain Connectivity. PMID 36074939 DOI: 10.1089/brain.2022.0047 |
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Kiely AP, Murray CE, Foti SC, Benson BC, Courtney R, Strand C, Lashley T, Holton JL. Immunohistochemical and Molecular Investigations Show Alteration in the Inflammatory Profile of Multiple System Atrophy Brain. Journal of Neuropathology and Experimental Neurology. PMID 29850876 DOI: 10.1093/jnen/nly035 |
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Holton JL, Lashley T, Ghiso J, Braendgaard H, Vidal R, Guerin CJ, Gibb G, Hanger DP, Rostagno A, Anderton BH, Strand C, Ayling H, Plant G, Frangione B, Bojsen-Møller M, et al. Familial Danish dementia: a novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-beta. Journal of Neuropathology and Experimental Neurology. 61: 254-67. PMID 11895040 DOI: 10.1093/Jnen/61.3.254 |
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Koriath CA, Bocchetta M, Brotherhood E, Woollacott IO, Norsworthy P, Simón-Sánchez J, Blauwendraat C, Dick KM, Gordon E, Harding SR, Fox NC, Crutch S, Warren JD, Revesz T, Lashley T, et al. The clinical, neuroanatomical, and neuropathologic phenotype of TBK1-associated frontotemporal dementia: A longitudinal case report. Alzheimer's & Dementia (Amsterdam, Netherlands). 6: 75-81. PMID 28229125 DOI: 10.1016/J.Dadm.2016.10.003 |
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Shafei R, Woollacott IOC, Mummery CJ, Bocchetta M, Guerreiro R, Bras J, Warren JD, Lashley T, Jaunmuktane Z, Rohrer JD. Two pathologically confirmed cases of novel mutations in the MAPT gene causing frontotemporal dementia. Neurobiology of Aging. PMID 31870644 DOI: 10.1016/J.Neurobiolaging.2019.11.009 |
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Ehrenberg AJ, Khatun A, Coomans E, Betts MJ, Capraro F, Thijssen EH, Senkevich K, Bharucha T, Jafarpour M, Young PNE, Jagust W, Carter SF, Lashley T, Grinberg LT, Pereira JB, et al. Relevance of biomarkers across different neurodegenerative. Alzheimer's Research & Therapy. 12: 56. PMID 32404143 DOI: 10.1186/S13195-020-00601-W |
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Walsh P, Sudre CH, Fiford CM, Ryan NS, Lashley T, Frost C, Barnes J. CSF amyloid is a consistent predictor of white matter hyperintensities across the disease course from aging to Alzheimer's disease. Neurobiology of Aging. 91: 5-14. PMID 32305782 DOI: 10.1016/j.neurobiolaging.2020.03.008 |
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Guerreiro R, Escott-Price V, Darwent L, Parkkinen L, Ansorge O, Hernandez DG, Nalls MA, Clark L, Honig L, Marder K, van der Flier W, Holstege H, Louwersheimer E, Lemstra A, Scheltens P, ... ... Lashley T, et al. Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases. Neurobiology of Aging. PMID 26643944 DOI: 10.1016/J.Neurobiolaging.2015.10.028 |
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Ryan NS, Lashley T, Revesz T, Dantu K, Fox NC, Morris HR. Spontaneous ARIA (amyloid-related imaging abnormalities) and cerebral amyloid angiopathy related inflammation in presenilin 1-associated familial Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 44: 1069-74. PMID 25408217 DOI: 10.3233/Jad-142325 |
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Camporesi E, Lashley T, Gobom J, Lantero-Rodriguez J, Hansson O, Zetterberg H, Blennow K, Becker B. Neuroligin-1 in brain and CSF of neurodegenerative disorders: investigation for synaptic biomarkers. Acta Neuropathologica Communications. 9: 19. PMID 33522967 DOI: 10.1186/s40478-021-01119-4 |
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Houlden H, Johnson J, Gardner-Thorpe C, Lashley T, Hernandez D, Worth P, Singleton AB, Hilton DA, Holton J, Revesz T, Davis MB, Giunti P, Giunti P, Wood NW. Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11. Nature Genetics. 39: 1434-6. PMID 18037885 DOI: 10.1038/ng.2007.43 |
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Sander K, Lashley T, Gami P, Gendron T, Lythgoe MF, Rohrer JD, Schott JM, Revesz T, Fox NC, Årstad E. Characterization of tau positron emission tomography tracer [(18)F]AV-1451 binding to postmortem tissue in Alzheimer's disease, primary tauopathies, and other dementias. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26892233 DOI: 10.1016/J.Jalz.2016.01.003 |
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Rueda-Carrasco J, Sokolova D, Lee SE, Childs T, Jurčáková N, Crowley G, De Schepper S, Ge JZ, Lachica JI, Toomey CE, Freeman OJ, Hardy J, Barnes SJ, Lashley T, Stevens B, et al. Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models. The Embo Journal. e113246. PMID 37575021 DOI: 10.15252/embj.2022113246 |
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Woollacott IOC, Bocchetta M, Sudre CH, Ridha BH, Strand C, Courtney R, Ourselin S, Cardoso MJ, Warren JD, Rossor MN, Revesz T, Fox NC, Holton JL, Lashley T, Rohrer JD. Pathological correlates of white matter hyperintensities in a case of progranulin mutation associated frontotemporal dementia. Neurocase. 1-9. PMID 30112957 DOI: 10.1080/13554794.2018.1506039 |
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Rostagno A, Lashley T, Ng D, Meyerson J, Braendgaard H, Plant G, Bojsen-Møller M, Holton J, Frangione B, Revesz T, Ghiso J. Preferential association of serum amyloid P component with fibrillar deposits in familial British and Danish dementias: similarities with Alzheimer's disease. Journal of the Neurological Sciences. 257: 88-96. PMID 17374542 DOI: 10.1016/J.Jns.2007.01.050 |
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Banerjee G, Collinge J, Fox NC, Lashley T, Mead S, Schott JM, Werring DJ, Ryan NS. Clinical considerations in early-onset cerebral amyloid angiopathy. Brain : a Journal of Neurology. PMID 37280119 DOI: 10.1093/brain/awad193 |
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Davidson YS, Flood L, Robinson AC, Nihei Y, Mori K, Rollinson S, Richardson A, Benson BC, Jones M, Snowden JS, Pickering-Brown S, Haass C, Lashley T, Mann DMA. Heterogeneous ribonuclear protein A3 (hnRNP A3) is present in dipeptide repeat protein containing inclusions in Frontotemporal Lobar Degeneration and Motor Neurone disease associated with expansions in C9orf72 gene. Acta Neuropathologica Communications. 5: 31. PMID 28431575 DOI: 10.1186/S40478-017-0437-5 |
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Revesz T, Holton JL, Lashley T, Plant G, Rostagno A, Ghiso J, Frangione B. Sporadic and familial cerebral amyloid angiopathies. Brain Pathology (Zurich, Switzerland). 12: 343-57. PMID 12146803 DOI: 10.1111/J.1750-3639.2002.Tb00449.X |
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Bandopadhyay R, Gatt A, Lashley T. Advances in the Understanding of Frontotemporal Dementia. Cells. 12. PMID 36899917 DOI: 10.3390/cells12050781 |
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Rasmussen J, Mahler J, Beschorner N, Kaeser SA, Häsler LM, Baumann F, Nyström S, Portelius E, Blennow K, Lashley T, Fox NC, Sepulveda-Falla D, Glatzel M, Oblak AL, Ghetti B, et al. Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 29158413 DOI: 10.1073/Pnas.1713215114 |
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Rohrer JD, Beck J, Plagnol V, Gordon E, Lashley T, Revesz T, Janssen JC, Fox NC, Warren JD, Rossor MN, Mead S, Schott JM. Exome sequencing reveals a novel partial deletion in the progranulin gene causing primary progressive aphasia. Journal of Neurology, Neurosurgery, and Psychiatry. 84: 1411-2. PMID 23904625 DOI: 10.1136/Jnnp-2013-306116 |
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Guerreiro R, Ross OA, Kun-Rodrigues C, Hernandez DG, Orme T, Eicher JD, Shepherd CE, Parkkinen L, Darwent L, Heckman MG, Scholz SW, Troncoso JC, Pletnikova O, Ansorge O, Clarimon J, ... ... Lashley T, et al. Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. The Lancet. Neurology. 17: 64-74. PMID 29263008 DOI: 10.1016/S1474-4422(17)30400-3 |
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Cicognola C, Brinkmalm G, Wahlgren J, Portelius E, Gobom J, Cullen NC, Hansson O, Parnetti L, Constantinescu R, Wildsmith K, Chen HH, Beach TG, Lashley T, Zetterberg H, Blennow K, et al. Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer's disease. Acta Neuropathologica. PMID 30547227 DOI: 10.1007/s00401-018-1948-2 |
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Michno W, Koutarapu S, Camacho R, Toomey C, Stringer K, Minta K, Ge J, Jha D, Fernandez-Rodriguez J, Brinkmalm G, Zetterberg H, Blennow K, Ryan NS, Lashley T, Hanrieder J. Chemical traits of cerebral amyloid angiopathy in familial British-, Danish-, and non-Alzheimer's dementias. Journal of Neurochemistry. PMID 36102248 DOI: 10.1111/jnc.15694 |
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Woollacott IOC, Toomey CE, Strand C, Courtney R, Benson BC, Rohrer JD, Lashley T. Microglial burden, activation and dystrophy patterns in frontotemporal lobar degeneration. Journal of Neuroinflammation. 17: 234. PMID 32778130 DOI: 10.1186/s12974-020-01907-0 |
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Rostagno A, Cabrera E, Lashley T, Ghiso J. N-terminally truncated Aβ4-x proteoforms and their relevance for Alzheimer's pathophysiology. Translational Neurodegeneration. 11: 30. PMID 35641972 DOI: 10.1186/s40035-022-00303-3 |
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Lantero-Rodriguez J, Snellman A, Benedet AL, Milà-Alomà M, Camporesi E, Montoliu-Gaya L, Ashton NJ, Vrillon A, Karikari TK, Gispert JD, Salvadó G, Shekari M, Toomey CE, Lashley TL, Zetterberg H, et al. P-tau235: a novel biomarker for staging preclinical Alzheimer's disease. Embo Molecular Medicine. e15098. PMID 34725927 DOI: 10.15252/emmm.202115098 |
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Tomidokoro Y, Tamaoka A, Holton JL, Lashley T, Frangione B, Revesz T, Rostagno A, Ghiso J. PYROGLUTAMATE FORMATION AT THE N-TERMINI OF ABRI MOLECULES IN FAMILIAL BRITISH DEMENTIA IS NOT RESTRICTED TO THE CENTRAL NERVOUS SYSTEM. Hirosaki Igaku = Hirosaki Medical Journal. 61: S262-S269. PMID 21037969 |
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Arber C, Lovejoy C, Harris L, Willumsen N, Alatza A, Casey JM, Lines G, Kerins C, Mueller AK, Zetterberg H, Hardy J, Ryan NS, Fox NC, Lashley T, Wray S. Familial Alzheimer's Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis. Cell Reports. 34: 108615. PMID 33440141 DOI: 10.1016/j.celrep.2020.108615 |
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Ryan NS, Biessels GJ, Kim L, Nicholas JM, Barber PA, Walsh P, Gami P, Morris HR, Bastos-Leite AJ, Schott JM, Beck J, Mead S, Chavez-Gutierrez L, de Strooper B, Rossor MN, ... ... Lashley T, et al. Genetic determinants of white matter hyperintensities and amyloid angiopathy in familial Alzheimer's disease. Neurobiology of Aging. PMID 26410308 DOI: 10.1016/J.Neurobiolaging.2015.08.026 |
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Chia R, Sabir MS, Bandres-Ciga S, Saez-Atienzar S, Reynolds RH, Gustavsson E, Walton RL, Ahmed S, Viollet C, Ding J, Makarious MB, Diez-Fairen M, Portley MK, Shah Z, Abramzon Y, ... ... Lashley T, et al. Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture. Nature Genetics. PMID 33589841 DOI: 10.1038/s41588-021-00785-3 |
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Guerreiro R, Escott-Price V, Hernandez DG, Kun-Rodrigues C, Ross OA, Orme T, Neto JL, Carmona S, Dehghani N, Eicher JD, Shepherd C, Parkkinen L, Darwent L, Heckman MG, Scholz SW, ... ... Lashley T, et al. Heritability and genetic variance of dementia with Lewy bodies. Neurobiology of Disease. PMID 30953760 DOI: 10.1016/J.Nbd.2019.04.004 |
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O'Connor A, Abel E, Fraser MR, Ryan NS, Jiménez DA, Koriath C, Chávez-Gutiérrez L, Ansorge O, Mummery CJ, Lashley T, Rossor MN, Polke JM, Mead S, Fox NC. A novel presenilin 1 duplication mutation (Ile168dup) causing Alzheimer's disease associated with myoclonus, seizures and pyramidal features. Neurobiology of Aging. PMID 33648786 DOI: 10.1016/j.neurobiolaging.2021.01.032 |
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Anazi S, Maddirevula S, Salpietro V, Asi YT, Alsahli S, Alhashem A, Shamseldin HE, AlZahrani F, Patel N, Ibrahim N, Abdulwahab FM, Hashem M, Alhashmi N, Al Murshedi F, Al Kindy A, ... ... Lashley T, et al. Expanding the genetic heterogeneity of intellectual disability. Human Genetics. PMID 28940097 DOI: 10.1007/s00439-017-1843-2 |
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Toomey CE, Heywood WE, Evans JR, Lachica J, Pressey SN, Foti SC, Al Shahrani M, D'Sa K, Hargreaves IP, Heales S, Orford M, Troakes C, Attems J, Gelpi E, Palkovits M, ... Lashley T, et al. Mitochondrial dysfunction is a key pathological driver of early stage Parkinson's. Acta Neuropathologica Communications. 10: 134. PMID 36076304 DOI: 10.1186/s40478-022-01424-6 |
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Bettencourt C, Miki Y, Piras IS, de Silva R, Foti SC, Talboom JS, Revesz T, Lashley T, Balazs R, Viré E, Warner TT, Huentelman MJ, Holton JL. MOBP and HIP1 in multiple system atrophy: new α-synuclein partners in glial cytoplasmic inclusions implicated in the disease pathogenesis. Neuropathology and Applied Neurobiology. PMID 33368549 DOI: 10.1111/nan.12688 |
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Michno W, Bowman A, Jha D, Minta K, Ge J, Koutarapu S, Zetterberg H, Blennow K, Lashley T, Heeren RMA, Hanrieder J. Spatial Neurolipidomics at the Single Amyloid-β Plaque Level in Postmortem Human Alzheimer's Disease Brain. Acs Chemical Neuroscience. PMID 38299453 DOI: 10.1021/acschemneuro.4c00006 |
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Miki Y, Tanji K, Shinnai K, Tanaka MT, Altay F, Foti SC, Strand C, Sasaki T, Kon T, Shimoyama S, Furukawa T, Nishijima H, Yamazaki H, Asi YT, Bettencourt C, ... ... Lashley T, et al. Pathological substrate of memory impairment in multiple system atrophy. Neuropathology and Applied Neurobiology. e12844. PMID 35906771 DOI: 10.1111/nan.12844 |
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Li JY, Englund E, Holton JL, Soulet D, Hagell P, Lees AJ, Lashley T, Quinn NP, Rehncrona S, Björklund A, Widner H, Revesz T, Lindvall O, Brundin P. Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nature Medicine. 14: 501-3. PMID 18391963 DOI: 10.1038/Nm1746 |
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Ly H, Verma N, Sharma S, Kotiya D, Despa S, Abner EL, Nelson PT, Jicha GA, Wilcock DM, Goldstein LB, Guerreiro R, Brás J, Hanson AJ, Craft S, Murray AJ, ... ... Lashley T, et al. The association of circulating amylin with β-amyloid in familial Alzheimer's disease. Alzheimer's & Dementia (New York, N. Y.). 7: e12130. PMID 33521236 DOI: 10.1002/trc2.12130 |
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Bettencourt C, Piras IS, Foti SC, Talboom J, Miki Y, Lashley T, Balazs R, Viré E, Warner TT, Huentelman MJ, Holton JL. Epigenomics and transcriptomics analyses of multiple system atrophy brain tissue supports a role for inflammatory processes in disease pathogenesis. Acta Neuropathologica Communications. 8: 71. PMID 32410669 DOI: 10.1186/S40478-020-00946-1 |
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Guerreiro R, Kara E, Le Ber I, Bras J, Rohrer JD, Taipa R, Lashley T, Dupuits C, Gurunlian N, Mochel F, Warren JD, Hannequin D, Sedel F, Depienne C, Camuzat A, et al. Genetic analysis of inherited leukodystrophies: genotype-phenotype correlations in the CSF1R gene. Jama Neurology. 70: 875-82. PMID 23649896 DOI: 10.1001/Jamaneurol.2013.698 |
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Ling H, Holton JL, Shaw K, Davey K, Lashley T, Revesz T. Histological evidence of chronic traumatic encephalopathy in a large series of neurodegenerative diseases. Acta Neuropathologica. PMID 26497674 DOI: 10.1007/s00401-015-1496-y |
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Magno L, Lessard CB, Martins M, Lang V, Cruz P, Asi Y, Katan M, Bilsland J, Lashley T, Chakrabarty P, Golde TE, Whiting PJ. Alzheimer's disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph. Alzheimer's Research & Therapy. 11: 16. PMID 30711010 DOI: 10.1186/S13195-019-0469-0 |
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Kvartsberg H, Lashley T, Murray CE, Brinkmalm G, Cullen NC, Höglund K, Zetterberg H, Blennow K, Portelius E. The intact postsynaptic protein neurogranin is reduced in brain tissue from patients with familial and sporadic Alzheimer's disease. Acta Neuropathologica. PMID 30244311 DOI: 10.1007/s00401-018-1910-3 |
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Chebli J, Rahmati M, Lashley T, Edeman B, Oldfors A, Zetterberg H, Abramsson A. The localization of amyloid precursor protein to ependymal cilia in vertebrates and its role in ciliogenesis and brain development in zebrafish. Scientific Reports. 11: 19115. PMID 34580355 DOI: 10.1038/s41598-021-98487-7 |
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2022 |
Willumsen N, Arber C, Lovejoy C, Toombs J, Alatza A, Weston PSJ, Chávez-Gutiérrez L, Hardy J, Zetterberg H, Fox NC, Ryan NS, Lashley T, Wray S. The PSEN1 E280G mutation leads to increased amyloid-β43 production in induced pluripotent stem cell neurons and deposition in brain tissue. Brain Communications. 5: fcac321. PMID 36687397 DOI: 10.1093/braincomms/fcac321 |
0.197 |
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2023 |
Murthy M, Rizzu P, Heutink P, Mill J, Lashley T, Bettencourt C. Epigenetic Age Acceleration in Frontotemporal Lobar Degeneration: A Comprehensive Analysis in the Blood and Brain. Cells. 12. PMID 37508584 DOI: 10.3390/cells12141922 |
0.196 |
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2022 |
Murthy M, Shireby G, Miki Y, Viré E, Lashley T, Warner TT, Mill J, Bettencourt C. Epigenetic age acceleration is associated with oligodendrocyte proportions in MSA and control brain tissue. Neuropathology and Applied Neurobiology. e12872. PMID 36542090 DOI: 10.1111/nan.12872 |
0.196 |
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2022 |
de Boni L, Watson AH, Zaccagnini L, Wallis A, Zhelcheska K, Kim N, Sanderson J, Jiang H, Martin E, Cantlon A, Rovere M, Liu L, Sylvester M, Lashley T, Dettmer U, et al. Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations. Acta Neuropathologica. PMID 35141810 DOI: 10.1007/s00401-022-02406-7 |
0.196 |
|
2019 |
Adams-Carr KL, Bocchetta M, Neason M, Holton JL, Lashley T, Warren JD, Rohrer JD. A case of TDP-43 type C pathology presenting as nonfluent variant primary progressive aphasia. Neurocase. 1-6. PMID 31747857 DOI: 10.1080/13554794.2019.1690665 |
0.194 |
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2011 |
Lashley T, Holton JL, Revesz T. TDP-43 pathology may occur in the BRI2 gene-related dementias. Acta Neuropathologica. 121: 559-60. PMID 21340582 DOI: 10.1007/s00401-011-0811-5 |
0.189 |
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2023 |
Verma N, Velmurugan GV, Winford E, Coburn H, Kotiya D, Leibold N, Radulescu L, Despa S, Chen KC, Van Eldik LJ, Nelson PT, Wilcock DM, Jicha GA, Stowe AM, Goldstein LB, ... ... Lashley T, et al. Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas. Communications Biology. 6: 2. PMID 36596993 DOI: 10.1038/s42003-022-04398-2 |
0.186 |
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2020 |
Nazir FH, Camporesi E, Brinkmalm G, Lashley T, Toomey CE, Kvartsberg H, Zetterberg H, Blennow K, Becker B. Molecular forms of neurogranin in cerebrospinal fluid. Journal of Neurochemistry. PMID 33249594 DOI: 10.1111/jnc.15252 |
0.185 |
|
2005 |
Tomidokoro Y, Lashley T, Rostagno A, Neubert TA, Bojsen-Møller M, Braendgaard H, Plant G, Holton J, Frangione B, Révész T, Ghiso J. Familial Danish dementia: co-existence of Danish and Alzheimer amyloid subunits (ADan AND A{beta}) in the absence of compact plaques. The Journal of Biological Chemistry. 280: 36883-94. PMID 16091362 DOI: 10.1074/Jbc.M504038200 |
0.185 |
|
2019 |
Gkanatsiou E, Portelius E, Toomey CE, Blennow K, Zetterberg H, Lashley T, Brinkmalm G. A distinct brain beta amyloid signature in cerebral amyloid angiopathy compared to Alzheimer's disease. Neuroscience Letters. 701: 125-131. PMID 30807796 DOI: 10.1016/j.neulet.2019.02.033 |
0.184 |
|
2023 |
De Schepper S, Ge JZ, Crowley G, Ferreira LSS, Garceau D, Toomey CE, Sokolova D, Rueda-Carrasco J, Shin SH, Kim JS, Childs T, Lashley T, Burden JJ, Sasner M, Sala Frigerio C, et al. Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease. Nature Neuroscience. PMID 36747024 DOI: 10.1038/s41593-023-01257-z |
0.183 |
|
2021 |
Gkanatsiou E, Nilsson J, Toomey CE, Vrillon A, Kvartsberg H, Portelius E, Zetterberg H, Blennow K, Brinkmalm A, Lashley T, Brinkmalm G. Amyloid pathology and synaptic loss in pathological aging. Journal of Neurochemistry. PMID 34473357 DOI: 10.1111/jnc.15487 |
0.183 |
|
2009 |
Song YJ, Halliday GM, Holton JL, Lashley T, O'Sullivan SS, McCann H, Lees AJ, Ozawa T, Williams DR, Lockhart PJ, Revesz TR. Degeneration in different parkinsonian syndromes relates to astrocyte type and astrocyte protein expression. Journal of Neuropathology and Experimental Neurology. 68: 1073-83. PMID 19918119 DOI: 10.1097/NEN.0b013e3181b66f1b |
0.183 |
|
2020 |
Bocchetta M, Iglesias Espinosa MDM, Lashley T, Warren JD, Rohrer JD. In vivo staging of frontotemporal lobar degeneration TDP-43 type C pathology. Alzheimer's Research & Therapy. 12: 34. PMID 32220237 DOI: 10.1186/s13195-020-00600-x |
0.182 |
|
2020 |
Walsh P, Sudre CH, Fiford CM, Ryan NS, Lashley T, Frost C, Barnes J. The age-dependent associations of white matter hyperintensities and neurofilament light in early- and late-stage Alzheimer's disease. Neurobiology of Aging. 97: 10-17. PMID 33070094 DOI: 10.1016/j.neurobiolaging.2020.09.008 |
0.182 |
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2022 |
Wagner J, Degenhardt K, Veit M, Louros N, Konstantoulea K, Skodras A, Wild K, Liu P, Obermüller U, Bansal V, Dalmia A, Häsler LM, Lambert M, De Vleeschouwer M, Davies HA, ... ... Lashley T, et al. Medin co-aggregates with vascular amyloid-β in Alzheimer's disease. Nature. PMID 36385530 DOI: 10.1038/s41586-022-05440-3 |
0.181 |
|
2024 |
Kac PR, González-Ortiz F, Emeršič A, Dulewicz M, Koutarapu S, Turton M, An Y, Smirnov D, Kulczyńska-Przybik A, Varma VR, Ashton NJ, Montoliu-Gaya L, Camporesi E, Winkel I, Paradowski B, ... ... Lashley T, et al. Plasma p-tau212 antemortem diagnostic performance and prediction of autopsy verification of Alzheimer's disease neuropathology. Nature Communications. 15: 2615. PMID 38521766 DOI: 10.1038/s41467-024-46876-7 |
0.179 |
|
2015 |
Portelius E, Lashley T, Westerlund A, Persson R, Fox NC, Blennow K, Revesz T, Zetterberg H. Brain amyloid-beta fragment signatures in pathological ageing and Alzheimer's disease by hybrid immunoprecipitation mass spectrometry. Neuro-Degenerative Diseases. 15: 50-7. PMID 25591542 DOI: 10.1159/000369465 |
0.176 |
|
2008 |
Lashley T, Holton JL, Gray E, Kirkham K, O'Sullivan SS, Hilbig A, Wood NW, Lees AJ, Revesz T. Cortical alpha-synuclein load is associated with amyloid-beta plaque burden in a subset of Parkinson's disease patients. Acta Neuropathologica. 115: 417-25. PMID 18185940 DOI: 10.1007/s00401-007-0336-0 |
0.176 |
|
2010 |
Van Deerlin VM, Sleiman PM, Martinez-Lage M, Chen-Plotkin A, Wang LS, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Grossman M, Arnold SE, Mann DM, Pickering-Brown SM, Seelaar H, Heutink P, ... ... Lashley T, et al. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nature Genetics. 42: 234-9. PMID 20154673 DOI: 10.1038/Ng.536 |
0.175 |
|
2019 |
Michno W, Nyström S, Wehrli P, Lashley T, Brinkmalm G, Guerard L, Syvänen S, Sehlin D, Kaya I, Brinet D, Nilsson KPR, Hammarström P, Blennow K, Zetterberg H, Hanrieder J. Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1-40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology. The Journal of Biological Chemistry. PMID 30814252 DOI: 10.1074/Jbc.Ra118.006604 |
0.175 |
|
2019 |
Shibata-Germanos S, Goodman JR, Grieg A, Trivedi CA, Benson BC, Foti SC, Faro A, Castellan RFP, Correra RM, Barber M, Ruhrberg C, Weller RO, Lashley T, Iliff JJ, Hawkins TA, et al. Structural and functional conservation of non-lumenized lymphatic endothelial cells in the mammalian leptomeninges. Acta Neuropathologica. PMID 31696318 DOI: 10.1007/S00401-019-02091-Z |
0.171 |
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2020 |
Ehrenberg AJ, Khatun A, Coomans E, Betts MJ, Capraro F, Thijssen EH, Senkevich K, Bharucha T, Jafarpour M, Young PNE, Jagust W, Carter SF, Lashley T, Grinberg LT, Pereira JB, et al. Correction to: Relevance of biomarkers across different neurodegenerative diseases. Alzheimer's Research & Therapy. 12: 71. PMID 32517788 DOI: 10.1186/S13195-020-00637-Y |
0.169 |
|
2016 |
Yarnall AJ, Lashley T, Ling H, Lees AJ, Coleman SY, O'Sullivan SS, Compta Y, Revesz T, Burn DJ. Apomorphine: A potential modifier of amyloid deposition in Parkinson's disease? Movement Disorders : Official Journal of the Movement Disorder Society. 31: 668-75. PMID 27156393 DOI: 10.1002/mds.26422 |
0.165 |
|
2022 |
Yang Y, Shi Y, Schweighauser M, Zhang X, Kotecha A, Murzin AG, Garringer HJ, Cullinane PW, Saito Y, Foroud T, Warner TT, Hasegawa K, Vidal R, Murayama S, Revesz T, ... ... Lashley T, et al. Structures of α-synuclein filaments from human brains with Lewy pathology. Nature. PMID 36108674 DOI: 10.1038/s41586-022-05319-3 |
0.164 |
|
2015 |
Lashley T, Gami P, Valizadeh N, Li A, Revesz T, Balazs R. Alterations in global DNA methylation and hydroxymethylation are not detected in Alzheimer's disease. Neuropathology and Applied Neurobiology. 41: 497-506. PMID 25201696 DOI: 10.1111/nan.12183 |
0.162 |
|
2022 |
Moscoso A, Wren MC, Lashley T, Arstad E, Murray ME, Fox NC, Sander K, Schöll M. Imaging tau pathology in Alzheimer's disease with positron emission tomography: lessons learned from imaging-neuropathology validation studies. Molecular Neurodegeneration. 17: 39. PMID 35659709 DOI: 10.1186/s13024-022-00543-x |
0.145 |
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2021 |
Chen CD, Joseph-Mathurin N, Sinha N, Zhou A, Li Y, Friedrichsen K, McCullough A, Franklin EE, Hornbeck R, Gordon B, Sharma V, Cruchaga C, Goate A, Karch C, McDade E, ... ... Lashley T, et al. Comparing amyloid-β plaque burden with antemortem PiB PET in autosomal dominant and late-onset Alzheimer disease. Acta Neuropathologica. PMID 34319442 DOI: 10.1007/s00401-021-02342-y |
0.145 |
|
2014 |
Swirski M, Miners JS, de Silva R, Lashley T, Ling H, Holton J, Revesz T, Love S. Evaluating the relationship between amyloid-β and α-synuclein phosphorylated at Ser129 in dementia with Lewy bodies and Parkinson's disease. Alzheimer's Research & Therapy. 6: 77. PMID 25452767 DOI: 10.1186/S13195-014-0077-Y |
0.144 |
|
2004 |
de Silva R, Lashley T, Revesz T, Lees A, Powers JM. Detecting tau isoforms in archival cases. Acta Neuropathologica. 107: 181-2. PMID 14652684 DOI: 10.1007/s00401-003-0795-x |
0.143 |
|
2004 |
Hope AD, Lashley T, Lees AJ, de Silva R. Failure in heat-shock protein expression in response to UBB+1 protein in progressive supranuclear palsy in humans. Neuroscience Letters. 359: 94-8. PMID 15050720 DOI: 10.1016/j.neulet.2003.12.127 |
0.134 |
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2020 |
Degenhardt K, Wagner J, Skodras A, Candlish M, Koppelmann AJ, Wild K, Maxwell R, Rotermund C, von Zweydorf F, Gloeckner CJ, Davies HA, Madine J, Del Turco D, Feederle R, Lashley T, et al. Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 32900929 DOI: 10.1073/pnas.2011133117 |
0.133 |
|
2024 |
Fu B, Brock EE, Andrews R, Breiter JC, Tian R, Toomey CE, Lachica J, Lashley T, Ryten M, Wood NW, Vendruscolo M, Gandhi S, Weiss LE, Beckwith JS, Lee SF. RASP: Optimal Single Puncta Detection in Complex Cellular Backgrounds. The Journal of Physical Chemistry. B. PMID 38593280 DOI: 10.1021/acs.jpcb.4c00174 |
0.127 |
|
2013 |
Saul A, Lashley T, Revesz T, Holton J, Ghiso JA, Coomaraswamy J, Wirths O. Abundant pyroglutamate-modified ABri and ADan peptides in extracellular and vascular amyloid deposits in familial British and Danish dementias. Neurobiology of Aging. 34: 1416-25. PMID 23261769 DOI: 10.1016/j.neurobiolaging.2012.11.014 |
0.127 |
|
2019 |
Bhattacharjee P, Öhrfelt A, Lashley T, Blennow K, Brinkmalm A, Zetterberg H. Mass spectrometric analysis of Lewy body-enriched α-synuclein in Parkinson's disease. Journal of Proteome Research. PMID 30943367 DOI: 10.1021/acs.jproteome.8b00982 |
0.123 |
|
2020 |
de Pablo-Fernández E, González-Herrero B, Cerdán Santacruz D, Rossor MN, Schott JM, Lashley T, Holton JL, Fox NC, Revesz T, Warren JD, Jaunmuktane Z, Rohrer JD, Warner TT. A Clinicopathologic Study of Movement Disorders in Frontotemporal Lobar Degeneration. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33155746 DOI: 10.1002/mds.28356 |
0.11 |
|
2017 |
Anazi S, Maddirevula S, Salpietro V, Asi YT, Alsahli S, Alhashem A, Shamseldin HE, AlZahrani F, Patel N, Ibrahim N, Abdulwahab FM, Hashem M, Alhashmi N, Al Murshedi F, Al Kindy A, ... ... Lashley T, et al. Correction to: Expanding the genetic heterogeneity of intellectual disability. Human Genetics. PMID 29288388 DOI: 10.1007/s00439-017-1859-7 |
0.092 |
|
2019 |
Josephs KA, Mackenzie I, Frosch MP, Bigio EH, Neumann M, Arai T, Dugger BN, Ghetti B, Grossman M, Hasegawa M, Herrup K, Holton J, Jellinger K, Lashley T, McAleese KE, et al. LATE to the PART-y. Brain : a Journal of Neurology. PMID 31359030 DOI: 10.1093/Brain/Awz224 |
0.023 |
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