Rajesh Khanna - Publications

Affiliations: 
 
Area:
Ion channel transport, presynaptic proteins

115 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Khanna R, Moutal A, White KA, Chefdeville A, Negrao de Assis P, Cai S, Swier VJ, Bellampalli SS, Giunta MD, Darbro BW, Quelle DE, Sieren JC, Wallace MR, Rogers CS, Meyerholz DK, et al. Assessment of nociception and related quality of life measures in a porcine model of Neurofibromatosis type 1. Pain. PMID 31246731 DOI: 10.1097/j.pain.0000000000001648  1
2019 Francois-Moutal L, Scott DD, Felemban R, Miranda VG, Sayegh MR, Perez-Miller S, Khanna R, Gokhale V, Zarnescu DC, Khanna M. A small molecule targeting TDP-43's RNA recognition motifs reduces locomotor defects in a Drosophila model of ALS. Acs Chemical Biology. PMID 31241884 DOI: 10.1021/acschembio.9b00481  0.6
2019 Moutal A, Luo S, Largent-Milnes TM, Vanderah TW, Khanna R. Cdk5-mediated CRMP2 phosphorylation is necessary and sufficient for peripheral neuropathic pain. Neurobiology of Pain (Cambridge, Mass.). 5. PMID 31080913 DOI: 10.1016/j.ynpai.2018.07.003  1
2019 Khanna R, Patwardhan A, Yang X, Li W, Cai S, Ji Y, Chew LA, Dorame A, Bellampalli SS, Schmoll RW, Gordon J, Moutal A, Vanderah TW, Porreca F, Ibrahim MM. Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light. The Journal of Pain : Official Journal of the American Pain Society. PMID 31054915 DOI: 10.1016/j.jpain.2019.04.008  1
2019 Cai S, Shan Z, Zhang Z, Moutal A, Khanna R. Activity of T-type calcium channels is independent of CRMP2 in sensory neurons. Channels (Austin, Tex.). 13: 147-152. PMID 31025580 DOI: 10.1080/19336950.2019.1608129  1
2019 Bellampalli SS, Khanna R. Towards a neurobiological understanding of pain in neurofibromatosis type 1: mechanisms and implications for treatment. Pain. 160: 1007-1018. PMID 31009417 DOI: 10.1097/j.pain.0000000000001486  0.76
2019 Shan Z, Cai S, Yu J, Zhang Z, Vallecillo TGM, Serafini MJ, Thomas AM, Pham NYN, Bellampalli SS, Moutal A, Zhou Y, Xu GB, Xu YM, Luo S, Patek M, ... ... Khanna R, et al. Reversal of peripheral neuropathic pain by the small-molecule natural product physalin F via block of CaV2.3 (R-type) and CaV2.2 (N-type) voltage-gated calcium channels. Acs Chemical Neuroscience. PMID 30946560 DOI: 10.1021/acschemneuro.9b00166  1
2019 Khanna R, Yu J, Yang X, Moutal A, Chefdeville A, Gokhale V, Shuja Z, Chew LA, Bellampalli SS, Luo S, François-Moutal L, Serafini MJ, Ha T, Perez-Miller S, Park KD, et al. Targeting the CaVα-CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy. Pain. PMID 30933958 DOI: 10.1097/j.pain.0000000000001524  1
2019 Moutal A, White KA, Chefdeville A, Laufmann RN, Vitiello PF, Feinstein D, Weimer JM, Khanna R. Dysregulation of CRMP2 Post-Translational Modifications Drive Its Pathological Functions. Molecular Neurobiology. PMID 30915713 DOI: 10.1007/s12035-019-1568-4  1
2019 Ji Y, Hu Y, Ren J, Khanna R, Yao Y, Chen Y, Li Q, Sun L. CRMP2-derived peptide ST2-104 (R9-CBD3) protects SH-SY5Y neuroblastoma cells against Aβ-induced neurotoxicity by inhibiting the pCRMP2/NMDAR2B signaling pathway. Chemico-Biological Interactions. PMID 30871964 DOI: 10.1016/j.cbi.2019.03.005  0.56
2019 Chew LA, Bellampalli SS, Dustrude ET, Khanna R. Mining the Na1.7 interactome: Opportunities for chronic pain therapeutics. Biochemical Pharmacology. 163: 9-20. PMID 30699328 DOI: 10.1016/j.bcp.2019.01.018  0.8
2018 Yu J, Moutal A, Dorame A, Bellampalli SS, Chefdeville A, Kanazawa I, Pham NYN, Park KD, Weimer JM, Khanna R. Phosphorylated CRMP2 Regulates Spinal Nociceptive Neurotransmission. Molecular Neurobiology. PMID 30565051 DOI: 10.1007/s12035-018-1445-6  1
2018 Cai S, Bellampalli SS, Yu J, Li W, Ji Y, Wijeratne EMK, Dorame A, Luo S, Shan Z, Khanna M, Moutal A, Streicher JM, Gunatilaka AAL, Khanna R. (-)-Hardwickiic acid and Hautriwaic acid induce antinociception via blockade of tetrodotoxin-sensitive voltage-dependent sodium channels. Acs Chemical Neuroscience. PMID 30525440 DOI: 10.1021/acschemneuro.8b00617  1
2018 Alberio L, Locarno A, Saponaro A, Romano E, Bercier V, Albadri S, Simeoni F, Moleri S, Pelucchi S, Porro A, Marcello E, Barsotti N, Kukovetz K, Boender AJ, Contestabile A, ... ... Khanna R, et al. A light-gated potassium channel for sustained neuronal inhibition. Nature Methods. PMID 30377377 DOI: 10.1038/s41592-018-0186-9  1
2018 Chew LA, Khanna R. CRMP2 and voltage-gated ion channels: potential roles in neuropathic pain. Neuronal Signaling. 2. PMID 30364788 DOI: 10.1042/NS20170220  0.8
2018 Parker SS, Moutal A, Cai S, Chandrasekaran S, Roman MR, Koshy AA, Khanna R, Zinsmaier KE, Mouneimne G. High Fidelity Cryopreservation and Recovery of Primary Rodent Cortical Neurons. Eneuro. 5. PMID 30263951 DOI: 10.1523/ENEURO.0135-18.2018  1
2018 Bellampalli SS, Ji Y, Moutal A, Cai S, Wijeratne EMK, Gandini MA, Yu J, Chefdeville A, Dorame A, Chew LA, Madura CL, Luo S, Molnar G, Khanna M, Streicher JM, ... ... Khanna R, et al. Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury-associated peripheral sensory neuropathy via block of N- and T-type calcium channels. Pain. PMID 30169422 DOI: 10.1097/j.pain.0000000000001385  1
2018 Francois-Moutal L, Jahanbakhsh S, Nelson A, Ray D, Scott DD, Hennefarth M, Moutal A, Perez-Miller S, Ambrose AJ, Al-Shamari A, Coursodon P, Meechoovet B, Reiman R, Lyons E, Beilstein M, ... ... Khanna R, et al. A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B). Acs Chemical Biology. PMID 30141626 DOI: 10.1021/acschembio.8b00745  1
2018 François-Moutal L, Scott DD, Perez-Miller S, Gokhale V, Khanna M, Khanna R. Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels. Channels (Austin, Tex.). 1-9. PMID 30081699 DOI: 10.1080/19336950.2018.1491244  0.6
2018 Garami A, Ibrahim M, Gilbraith K, Khanna R, Pakai E, Miko A, Pinter E, Romanovsky AA, Porreca F, Patwardhan AM. In Reply. Anesthesiology. 129: 378-379. PMID 30020181 DOI: 10.1097/ALN.0000000000002294  0.48
2018 White KA, Swier VJ, Cain JT, Kohlmeyer JL, Meyerholz DK, Tanas MR, Uthoff J, Hammond E, Li H, Rohret FA, Goeken A, Chan CH, Leidinger MR, Umesalma S, Wallace MR, ... ... Khanna R, et al. A porcine model of neurofibromatosis type 1 that mimics the human disease. Jci Insight. 3. PMID 29925695 DOI: 10.1172/jci.insight.120402  1
2018 François-Moutal L, Dustrude ET, Wang Y, Brustovetsky T, Dorame A, Ju W, Moutal A, Perez-Miller S, Brustovetsky N, Gokhale V, Khanna M, Khanna R. Inhibition of the Ubc9 E2 SUMO conjugating enzyme-CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain. Pain. PMID 29847471 DOI: 10.1097/j.pain.0000000000001294  1
2018 Moutal A, Sun L, Yang X, Li W, Cai S, Luo S, Khanna R. CRMP2 Neurofibromin Interface Drives NF1-related Pain. Neuroscience. PMID 29655575 DOI: 10.1016/j.neuroscience.2018.04.002  1
2018 Parrilla-Carrero J, Buchta WC, Goswamee P, Culver O, McKendrick G, Harlan B, Moutal A, Penrod R, Khanna R, Kalivas P, Riegel AC. Restoration of Kv7 channel mediated inhibition reduces cued-reinstatement of cocaine seeking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29636392 DOI: 10.1523/JNEUROSCI.2767-17.2018  1
2018 Moutal A, Khanna R. Unconventional Signaling by Extracellular CRMP2: Possible Role as an Atypical Neurotransmitter? Neuroscience. 376: 224-226. PMID 29555038 DOI: 10.1016/j.neuroscience.2018.02.025  1
2017 Meyerholz DK, Ofori-Amanfo GK, Leidinger MR, Goeken JA, Khanna R, Sieren JC, Darbro BW, Quelle DE, Weimer JM. Immunohistochemical Markers for Prospective Studies in Neurofibromatosis-1 Porcine Models. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 22155417729357. PMID 28846462 DOI: 10.1369/0022155417729357  0.52
2017 Moutal A, Cai S, Luo S, Voisin R, Khanna R. CRMP2 is necessary for Neurofibromatosis type 1 related pain. Channels (Austin, Tex.). 0. PMID 28837387 DOI: 10.1080/19336950.2017.1370524  1
2017 Moutal A, Yang X, Li W, Gilbraith KB, Luo S, Cai S, François-Moutal L, Chew LA, Yeon SK, Bellampalli SS, Qu C, Xie JY, Ibrahim MM, Khanna M, Park KD, ... ... Khanna R, et al. CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide. Pain. PMID 28809766 DOI: 10.1097/j.pain.0000000000001002  1
2017 Garami A, Ibrahim M, Gilbraith K, Khanna R, Pakai E, Miko A, Pinter E, Romanovsky AA, Porreca F, Patwardhan AM. Transient Receptor Potential Vanilloid 1 Antagonists Prevent Anesthesia-induced Hypothermia and Decrease Postincisional Opioid Dose Requirements in Rodents. Anesthesiology. PMID 28806222 DOI: 10.1097/ALN.0000000000001812  0.48
2017 Moutal A, Wang Y, Yang X, Ji Y, Luo S, Dorame A, Bellampalli SS, Chew LA, Cai S, Dustrude ET, Keener JE, Marty MT, Vanderah TW, Khanna R. Dissecting the role of the CRMP2-Neurofibromin complex on pain behaviors. Pain. PMID 28767512 DOI: 10.1097/j.pain.0000000000001026  1
2017 Moutal A, Villa LS, Yeon SK, Householder KT, Park KD, Sirianni RW, Khanna R. CRMP2 Phosphorylation Drives Glioblastoma Cell Proliferation. Molecular Neurobiology. PMID 28660485 DOI: 10.1007/s12035-017-0653-9  1
2017 Yeh CY, Bulas AM, Moutal A, Saloman JL, Hartnett KA, Anderson CT, Tzounopoulos T, Sun D, Khanna R, Aizenman E. Targeting a Potassium Channel/Syntaxin Interaction Ameliorates Cell Death in Ischemic Stroke. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28483976 DOI: 10.1523/JNEUROSCI.3811-16.2017  1
2017 Dustrude ET, Perez-Miller S, François-Moutal L, Moutal A, Khanna M, Khanna R. A single structurally conserved SUMOylation site in CRMP2 controls NaV1.7 function. Channels (Austin, Tex.). 0. PMID 28277940 DOI: 10.1080/19336950.2017.1299838  1
2017 Moutal A, Li W, Wang Y, Ju W, Luo S, Cai S, François-Moutal L, Perez-Miller S, Hu J, Dustrude ET, Vanderah TW, Gokhale V, Khanna M, Khanna R. Homology-guided mutational analysis reveals the functional requirements for antinociceptive specificity of CRMP2-derived peptides. British Journal of Pharmacology. PMID 28161890 DOI: 10.1111/bph.13737  1
2017 Ibrahim MM, Patwardhan A, Gilbraith KB, Moutal A, Yang X, Chew LA, Largent-Milnes T, Malan TP, Vanderah TW, Porreca F, Khanna R. Long-lasting antinociceptive effects of green light in acute and chronic pain in rats. Pain. 158: 347-360. PMID 28092651 DOI: 10.1097/j.pain.0000000000000767  1
2016 Dustrude ET, Moutal A, Yang X, Wang Y, Khanna M, Khanna R. Hierarchical CRMP2 posttranslational modifications control NaV1.7 function. Proceedings of the National Academy of Sciences of the United States of America. PMID 27940916 DOI: 10.1073/pnas.1610531113  1
2016 Moutal A, Eyde N, Telemi E, Park KD, Xie JY, Dodick DW, Porreca F, Khanna R. Efficacy of (S)-Lacosamide in preclinical models of cephalic pain. Pain Reports (Baltimore, Md.). 1. PMID 27917413 DOI: 10.1097/PR9.0000000000000565  1
2016 Xie JY, Chew LA, Yang X, Wang Y, Qu C, Wang Y, Federici LM, Fitz SD, Ripsch MS, Due MR, Moutal A, Khanna M, White FA, Vanderah TW, Johnson PL, ... ... Khanna R, et al. Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential. Pain. 157: 2124-2140. PMID 27537210 DOI: 10.1097/j.pain.0000000000000628  0.52
2016 Moutal A, Dustrude ET, Khanna R. Sensitization of Ion Channels Contributes to Central and Peripheral Dysfunction in Neurofibromatosis Type 1. Molecular Neurobiology. PMID 27167129 DOI: 10.1007/s12035-016-9907-1  0.92
2016 Moutal A, Chew LA, Yang X, Wang Y, Yeon SK, Telemi E, Meroueh S, Park KD, Shrinivasan R, Gilbraith KB, Qu C, Xie JY, Patwardhan A, Vanderah TW, Khanna M, ... ... Khanna R, et al. (S)-Lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology. Pain. PMID 26967696 DOI: 10.1097/j.pain.0000000000000555  0.92
2015 Shimomura A, Patel D, Wilson SM, Koehler KR, Khanna R, Hashino E. Tlx3 Promotes Glutamatergic Neuronal Subtype Specification through Direct Interactions with the Chromatin Modifier CBP. Plos One. 10: e0135060. PMID 26258652 DOI: 10.1371/journal.pone.0135060  0.72
2015 Moutal A, Honnorat J, Massoma P, Désormeaux P, Bertrand C, Malleval C, Watrin C, Chounlamountri N, Mayeur ME, Besançon R, Naudet N, Magadoux L, Khanna R, Ducray F, Meyronet D, et al. CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling. Cancer Research. 75: 3519-28. PMID 26122847 DOI: 10.1158/0008-5472.CAN-14-0631  0.92
2015 Quach TT, Honnorat J, Kolattukudy PE, Khanna R, Duchemin AM. CRMPs: critical molecules for neurite morphogenesis and neuropsychiatric diseases. Molecular Psychiatry. PMID 26077693 DOI: 10.1038/mp.2015.77  0.92
2015 Torregrosa R, Yang XF, Dustrude ET, Cummins TR, Khanna R, Kohn H. Chimeric derivatives of functionalized amino acids and α-aminoamides: Compounds with anticonvulsant activity in seizure models and inhibitory actions on central, peripheral, and cardiac isoforms of voltage-gated sodium channels. Bioorganic & Medicinal Chemistry. 23: 3655-66. PMID 25922183 DOI: 10.1016/j.bmc.2015.04.014  0.92
2015 Moutal A, François-Moutal L, Perez-Miller S, Cottier K, Chew LA, Yeon SK, Dai J, Park KD, Khanna M, Khanna R. (S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5. Molecular Neurobiology. PMID 25846820 DOI: 10.1007/s12035-015-9141-2  0.92
2015 François-Moutal L, Wang Y, Moutal A, Cottier KE, Melemedjian OK, Yang X, Wang Y, Ju W, Largent-Milnes TM, Khanna M, Vanderah TW, Khanna R. A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors. Pain. 156: 1247-64. PMID 25782368 DOI: 10.1097/j.pain.0000000000000147  0.92
2015 Park KD, Yang XF, Dustrude ET, Wang Y, Ripsch MS, White FA, Khanna R, Kohn H. Chimeric agents derived from the functionalized amino acid, lacosamide, and the α-aminoamide, safinamide: evaluation of their inhibitory actions on voltage-gated sodium channels, and antiseizure and antinociception activities and comparison with lacosamide and safinamide. Acs Chemical Neuroscience. 6: 316-30. PMID 25418676 DOI: 10.1021/cn5002182  0.92
2015 Wilson SM, Khanna R. Specific binding of lacosamide to collapsin response mediator protein 2 (CRMP2) and direct impairment of its canonical function: implications for the therapeutic potential of lacosamide. Molecular Neurobiology. 51: 599-609. PMID 24944082 DOI: 10.1007/s12035-014-8775-9  0.92
2015 Quach TT, Honnorat J, Kolattukudy PE, Khanna R, Duchemin AM. Collapsin response mediator protein 3 increases the dendritic arborization of hippocampal neurons Molecular Psychiatry. 20: 1027. DOI: 10.1038/mp.2015.123  0.92
2014 Moutal A, François-Moutal L, Brittain JM, Khanna M, Khanna R. Differential neuroprotective potential of CRMP2 peptide aptamers conjugated to cationic, hydrophobic, and amphipathic cell penetrating peptides. Frontiers in Cellular Neuroscience. 8: 471. PMID 25674050 DOI: 10.3389/fncel.2014.00471  0.92
2014 Molosh AI, Johnson PL, Spence JP, Arendt D, Federici LM, Bernabe C, Janasik SP, Segu ZM, Khanna R, Goswami C, Zhu W, Park SJ, Li L, Mechref YS, Clapp DW, et al. Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase. Nature Neuroscience. 17: 1583-90. PMID 25242307 DOI: 10.1038/nn.3822  0.92
2014 Due MR, Yang XF, Allette YM, Randolph AL, Ripsch MS, Wilson SM, Dustrude ET, Khanna R, White FA. Carbamazepine potentiates the effectiveness of morphine in a rodent model of neuropathic pain. Plos One. 9: e107399. PMID 25221944 DOI: 10.1371/journal.pone.0107399  0.92
2014 Wilson SM, Moutal A, Melemedjian OK, Wang Y, Ju W, François-Moutal L, Khanna M, Khanna R. The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth. Frontiers in Cellular Neuroscience. 8: 196. PMID 25104922 DOI: 10.3389/fncel.2014.00196  0.92
2014 Allette YM, Due MR, Wilson SM, Feldman P, Ripsch MS, Khanna R, White FA. Identification of a functional interaction of HMGB1 with Receptor for Advanced Glycation End-products in a model of neuropathic pain. Brain, Behavior, and Immunity. 42: 169-77. PMID 25014009 DOI: 10.1016/j.bbi.2014.06.199  0.92
2014 Lee H, Park KD, Torregrosa R, Yang XF, Dustrude ET, Wang Y, Wilson SM, Barbosa C, Xiao Y, Cummins TR, Khanna R, Kohn H. Substituted N-(biphenyl-4'-yl)methyl (R)-2-acetamido-3-methoxypropionamides: potent anticonvulsants that affect frequency (use) dependence and slow inactivation of sodium channels. Journal of Medicinal Chemistry. 57: 6165-82. PMID 25004277 DOI: 10.1021/jm500707r  0.92
2014 Wilson SM, Ki Yeon S, Yang XF, Park KD, Khanna R. Differential regulation of collapsin response mediator protein 2 (CRMP2) phosphorylation by GSK3ß and CDK5 following traumatic brain injury. Frontiers in Cellular Neuroscience. 8: 135. PMID 24904280 DOI: 10.3389/fncel.2014.00135  0.92
2014 Brustovetsky T, Pellman JJ, Yang XF, Khanna R, Brustovetsky N. Collapsin response mediator protein 2 (CRMP2) interacts with N-methyl-D-aspartate (NMDA) receptor and Na+/Ca2+ exchanger and regulates their functional activity. The Journal of Biological Chemistry. 289: 7470-82. PMID 24474686 DOI: 10.1074/jbc.M113.518472  0.92
2014 Ikram-ul-Haq M, Khanna R, Wang Y, Sahajwalla V. A Novel X-ray Micro-diffraction Approach for Structural Characterization of Trace Quantities of Secondary Phases in Al2O3-C/Fe System Metallurgical and Materials Transactions B: Process Metallurgy and Materials Processing Science. 45: 1970-1973. DOI: 10.1007/s11663-014-0201-1  0.44
2013 Ju W, Wu J, Pritz MB, Khanna R. CHARACTERIZING CALCIUM INFLUX VIA VOLTAGE- AND LIGAND-GATED CALCIUM CHANNELS IN EMBRYONIC ALLIGATOR NEURONS IN CULTURE. Translational Neuroscience. 4. PMID 24260711 DOI: 10.2478/s13380-013-0132-3  0.92
2013 Lee H, Gold AS, Yang XF, Khanna R, Kohn H. Benzyloxybenzylammonium chlorides: Simple amine salts that display anticonvulsant activity. Bioorganic & Medicinal Chemistry. 21: 7655-62. PMID 24238903 DOI: 10.1016/j.bmc.2013.10.031  0.92
2013 Quach TT, Wilson SM, Rogemond V, Chounlamountri N, Kolattukudy PE, Martinez S, Khanna M, Belin MF, Khanna R, Honnorat J, Duchemin AM. Mapping CRMP3 domains involved in dendrite morphogenesis and voltage-gated calcium channel regulation. Journal of Cell Science. 126: 4262-73. PMID 23868973 DOI: 10.1242/jcs.131409  0.92
2013 Dustrude ET, Wilson SM, Ju W, Xiao Y, Khanna R. CRMP2 protein SUMOylation modulates NaV1.7 channel trafficking. The Journal of Biological Chemistry. 288: 24316-31. PMID 23836888 DOI: 10.1074/jbc.M113.474924  0.92
2013 Feldman P, Khanna R. Challenging the catechism of therapeutics for chronic neuropathic pain: Targeting CaV2.2 interactions with CRMP2 peptides. Neuroscience Letters. 557: 27-36. PMID 23831344 DOI: 10.1016/j.neulet.2013.06.057  0.92
2013 Zhang YH, Khanna R, Nicol GD. Nerve growth factor/p75 neurotrophin receptor-mediated sensitization of rat sensory neurons depends on membrane cholesterol. Neuroscience. 248: 562-70. PMID 23811397 DOI: 10.1016/j.neuroscience.2013.06.039  0.92
2013 Lee H, Park KD, Yang XF, Dustrude ET, Wilson SM, Khanna R, Kohn H. (Biphenyl-4-yl)methylammonium chlorides: potent anticonvulsants that modulate Na+ currents. Journal of Medicinal Chemistry. 56: 5931-9. PMID 23772678 DOI: 10.1021/jm4007092  0.92
2013 Ju W, Li Q, Wilson SM, Brittain JM, Meroueh L, Khanna R. SUMOylation alters CRMP2 regulation of calcium influx in sensory neurons. Channels (Austin, Tex.). 7: 153-9. PMID 23510938 DOI: 10.4161/chan.24224  0.92
2013 Park KD, Yang XF, Lee H, Dustrude ET, Wang Y, Khanna R, Kohn H. Discovery of lacosamide affinity bait agents that exhibit potent voltage-gated sodium channel blocking properties. Acs Chemical Neuroscience. 4: 463-74. PMID 23509982 DOI: 10.1021/cn300188h  0.92
2013 Mani T, Wang F, Knabe WE, Sinn AL, Khanna M, Jo I, Sandusky GE, Sledge GW, Jones DR, Khanna R, Pollok KE, Meroueh SO. Small-molecule inhibition of the uPAR·uPA interaction: synthesis, biochemical, cellular, in vivo pharmacokinetics and efficacy studies in breast cancer metastasis. Bioorganic & Medicinal Chemistry. 21: 2145-55. PMID 23411397 DOI: 10.1016/j.bmc.2012.12.047  0.92
2013 Ju W, Li Q, Allette YM, Ripsch MS, White FA, Khanna R. Suppression of pain-related behavior in two distinct rodent models of peripheral neuropathy by a homopolyarginine-conjugated CRMP2 peptide. Journal of Neurochemistry. 124: 869-79. PMID 23106100 DOI: 10.1111/jnc.12070  0.92
2012 Khanna R, Wilson SM, Brittain JM, Weimer J, Sultana R, Butterfield A, Hensley K. Opening Pandora's jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders. Future Neurology. 7: 749-771. PMID 23308041 DOI: 10.2217/FNL.12.68  0.92
2012 King AM, Yang XF, Wang Y, Dustrude ET, Barbosa C, Due MR, Piekarz AD, Wilson SM, White FA, Salomé C, Cummins TR, Khanna R, Kohn H. Identification of the benzyloxyphenyl pharmacophore: a structural unit that promotes sodium channel slow inactivation. Acs Chemical Neuroscience. 3: 1037-49. PMID 23259039 DOI: 10.1021/cn300129d  0.92
2012 Brittain JM, Wang Y, Eruvwetere O, Khanna R. Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2. Febs Letters. 586: 3813-8. PMID 23022559 DOI: 10.1016/j.febslet.2012.09.022  0.92
2012 Due MR, Piekarz AD, Wilson N, Feldman P, Ripsch MS, Chavez S, Yin H, Khanna R, White FA. Neuroexcitatory effects of morphine-3-glucuronide are dependent on Toll-like receptor 4 signaling. Journal of Neuroinflammation. 9: 200. PMID 22898544 DOI: 10.1186/1742-2094-9-200  0.92
2012 Wilson SM, Schmutzler BS, Brittain JM, Dustrude ET, Ripsch MS, Pellman JJ, Yeum TS, Hurley JH, Hingtgen CM, White FA, Khanna R. Inhibition of transmitter release and attenuation of anti-retroviral-associated and tibial nerve injury-related painful peripheral neuropathy by novel synthetic Ca2+ channel peptides. The Journal of Biological Chemistry. 287: 35065-77. PMID 22891239 DOI: 10.1074/jbc.M112.378695  0.92
2012 Piekarz AD, Due MR, Khanna M, Wang B, Ripsch MS, Wang R, Meroueh SO, Vasko MR, White FA, Khanna R. CRMP-2 peptide mediated decrease of high and low voltage-activated calcium channels, attenuation of nociceptor excitability, and anti-nociception in a model of AIDS therapy-induced painful peripheral neuropathy. Molecular Pain. 8: 54. PMID 22828369 DOI: 10.1186/1744-8069-8-54  0.92
2012 Feldman P, Due MR, Ripsch MS, Khanna R, White FA. The persistent release of HMGB1 contributes to tactile hyperalgesia in a rodent model of neuropathic pain. Journal of Neuroinflammation. 9: 180. PMID 22824385 DOI: 10.1186/1742-2094-9-180  0.92
2012 Brittain MK, Brustovetsky T, Brittain JM, Khanna R, Cummins TR, Brustovetsky N. Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons. Neuropharmacology. 63: 974-82. PMID 22820271 DOI: 10.1016/j.neuropharm.2012.07.012  0.92
2012 Ripsch MS, Ballard CJ, Khanna M, Hurley JH, White FA, Khanna R. A PEPTIDE UNCOUPLING CRMP-2 FROM THE PRESYNAPTIC Ca(2+) CHANNEL COMPLEX DEMONSTRATES EFFICACY IN ANIMAL MODELS OF MIGRAINE AND AIDS THERAPY-INDUCED NEUROPATHY. Translational Neuroscience. 3: 1-8. PMID 22662308 DOI: 10.2478/s13380-012-0002-4  0.92
2012 Brittain JM, Wang Y, Wilson SM, Khanna R. Regulation of CREB signaling through L-type Ca2+ channels by Nipsnap-2. Channels (Austin, Tex.). 6: 94-102. PMID 22627147 DOI: 10.4161/chan.19415  0.92
2012 Wilson SM, Xiong W, Wang Y, Ping X, Head JD, Brittain JM, Gagare PD, Ramachandran PV, Jin X, Khanna R. Prevention of posttraumatic axon sprouting by blocking collapsin response mediator protein 2-mediated neurite outgrowth and tubulin polymerization. Neuroscience. 210: 451-66. PMID 22433297 DOI: 10.1016/j.neuroscience.2012.02.038  0.92
2012 Brittain JM, Pan R, You H, Brustovetsky T, Brustovetsky N, Zamponi GW, Lee WH, Khanna R. Disruption of NMDAR-CRMP-2 signaling protects against focal cerebral ischemic damage in the rat middle cerebral artery occlusion model. Channels (Austin, Tex.). 6: 52-9. PMID 22373559 DOI: 10.4161/chan.18919  0.92
2012 Brittain MK, Brustovetsky T, Sheets PL, Brittain JM, Khanna R, Cummins TR, Brustovetsky N. Delayed calcium dysregulation in neurons requires both the NMDA receptor and the reverse Na+/Ca2+ exchanger. Neurobiology of Disease. 46: 109-17. PMID 22249110 DOI: 10.1016/j.nbd.2011.12.051  0.92
2011 Wilson SM, Zhu T, Khanna R, Pritz MB. QUANTITATIVE RT-PCR ANALYSES OF FIVE EVOLUTIONARY CONSERVED GENES IN ALLIGATOR BRAINS DURING DEVELOPMENT. Translational Neuroscience. 2: 339-343. PMID 22379598 DOI: 10.2478/s13380-011-0036-z  0.92
2011 Wang Y, Khanna R. VOLTAGE-GATED CALCIUM CHANNELS ARE NOT AFFECTED BY THE NOVEL ANTI-EPILEPTIC DRUG LACOSAMIDE. Translational Neuroscience. 2: 13-22. PMID 21949591 DOI: 10.2478/s13380-011-0002-9  0.92
2011 Khanna M, Wang F, Jo I, Knabe WE, Wilson SM, Li L, Bum-Erdene K, Li J, W Sledge G, Khanna R, Meroueh SO. Targeting multiple conformations leads to small molecule inhibitors of the uPAR·uPA protein-protein interaction that block cancer cell invasion. Acs Chemical Biology. 6: 1232-43. PMID 21875078 DOI: 10.1021/cb200180m  0.92
2011 Brittain JM, Chen L, Wilson SM, Brustovetsky T, Gao X, Ashpole NM, Molosh AI, You H, Hudmon A, Shekhar A, White FA, Zamponi GW, Brustovetsky N, Chen J, Khanna R. Neuroprotection against traumatic brain injury by a peptide derived from the collapsin response mediator protein 2 (CRMP2). The Journal of Biological Chemistry. 286: 37778-92. PMID 21832084 DOI: 10.1074/jbc.M111.255455  0.92
2011 Wilson SM, Brittain JM, Piekarz AD, Ballard CJ, Ripsch MS, Cummins TR, Hurley JH, Khanna M, Hammes NM, Samuels BC, White FA, Khanna R. Further insights into the antinociceptive potential of a peptide disrupting the N-type calcium channel-CRMP-2 signaling complex. Channels (Austin, Tex.). 5: 449-56. PMID 21829088 DOI: 10.4161/chan.5.5.17363  0.92
2011 Wang Y, Wilson SM, Brittain JM, Ripsch MS, Salomé C, Park KD, White FA, Khanna R, Kohn H. Merging Structural Motifs of Functionalized Amino Acids and α-Aminoamides Results in Novel Anticonvulsant Compounds with Significant Effects on Slow and Fast Inactivation of Voltage-gated Sodium Channels and in the Treatment of Neuropathic Pain. Acs Chemical Neuroscience. 2: 317-322. PMID 21765969 DOI: 10.1021/cn200024z  0.92
2011 Brittain JM, Duarte DB, Wilson SM, Zhu W, Ballard C, Johnson PL, Liu N, Xiong W, Ripsch MS, Wang Y, Fehrenbacher JC, Fitz SD, Khanna M, Park CK, Schmutzler BS, ... ... Khanna R, et al. Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca²⁺ channel complex. Nature Medicine. 17: 822-9. PMID 21642979 DOI: 10.1038/nm.2345  0.92
2011 Wang Y, Park KD, Salome C, Wilson SM, Stables JP, Liu R, Khanna R, Kohn H. Development and characterization of novel derivatives of the antiepileptic drug lacosamide that exhibit far greater enhancement in slow inactivation of voltage-gated sodium channels. Acs Chemical Neuroscience. 2: 90-106. PMID 21532923 DOI: 10.1021/cn100089b  0.92
2011 Quach TT, Wang Y, Khanna R, Chounlamountri N, Auvergnon N, Honnorat J, Duchemin AM. Effect of CRMP3 expression on dystrophic dendrites of hippocampal neurons. Molecular Psychiatry. 16: 689-91. PMID 21339751 DOI: 10.1038/mp.2011.6  0.92
2010 Wang Y, Brittain JM, Wilson SM, Hingtgen CM, Khanna R. ALTERED CALCIUM CURRENTS AND AXONAL GROWTH IN Nf1 HAPLOINSUFFICIENT MICE. Translational Neuroscience. 1: 106-114. PMID 21949590 DOI: 10.2478/v10134-010-0025-8  0.92
2010 Wang Y, Brittain JM, Wilson SM, Khanna R. Emerging roles of collapsin response mediator proteins (CRMPs) as regulators of voltage-gated calcium channels and synaptic transmission. Communicative & Integrative Biology. 3: 172-5. PMID 20585514  0.72
2010 Wang Y, Brittain JM, Jarecki BW, Park KD, Wilson SM, Wang B, Hale R, Meroueh SO, Cummins TR, Khanna R. In silico docking and electrophysiological characterization of lacosamide binding sites on collapsin response mediator protein-2 identifies a pocket important in modulating sodium channel slow inactivation. The Journal of Biological Chemistry. 285: 25296-307. PMID 20538611 DOI: 10.1074/jbc.M110.128801  0.92
2009 Chi XX, Schmutzler BS, Brittain JM, Wang Y, Hingtgen CM, Nicol GD, Khanna R. Regulation of N-type voltage-gated calcium channels (Cav2.2) and transmitter release by collapsin response mediator protein-2 (CRMP-2) in sensory neurons. Journal of Cell Science. 122: 4351-62. PMID 19903690 DOI: 10.1242/jcs.053280  0.92
2009 Brittain JM, Piekarz AD, Wang Y, Kondo T, Cummins TR, Khanna R. An atypical role for collapsin response mediator protein 2 (CRMP-2) in neurotransmitter release via interaction with presynaptic voltage-gated calcium channels. The Journal of Biological Chemistry. 284: 31375-90. PMID 19755421 DOI: 10.1074/jbc.M109.009951  0.92
2007 Chan AW, Khanna R, Li Q, Stanley EF. Munc18: a presynaptic transmitter release site N type (CaV2.2) calcium channel interacting protein. Channels (Austin, Tex.). 1: 11-20. PMID 19170253 DOI: 10.4161/chan.3694  0.92
2007 Khanna R, Li Q, Schlichter LC, Stanley EF. The transmitter release-site CaV2.2 channel cluster is linked to an endocytosis coat protein complex. The European Journal of Neuroscience. 26: 560-74. PMID 17686037 DOI: 10.1111/j.1460-9568.2007.05681.x  0.92
2007 Khanna R, Li Q, Bewersdorf J, Stanley EF. The presynaptic CaV2.2 channel-transmitter release site core complex. The European Journal of Neuroscience. 26: 547-59. PMID 17686036 DOI: 10.1111/j.1460-9568.2007.05680.x  0.92
2007 Khanna R, Zougman A, Stanley EF. A proteomic screen for presynaptic terminal N-type calcium channel (CaV2.2) binding partners. Journal of Biochemistry and Molecular Biology. 40: 302-14. PMID 17562281  0.92
2006 Khanna R, Li Q, Stanley EF. 'Fractional recovery' analysis of a presynaptic synaptotagmin 1-anchored endocytic protein complex. Plos One. 1: e67. PMID 17183698 DOI: 10.1371/journal.pone.0000067  0.92
2006 Khanna R, Li Q, Sun L, Collins TJ, Stanley EF. N type Ca2+ channels and RIM scaffold protein covary at the presynaptic transmitter release face but are components of independent protein complexes. Neuroscience. 140: 1201-8. PMID 16757118 DOI: 10.1016/j.neuroscience.2006.04.053  0.92
2006 Sun L, Li Q, Khanna R, Chan AW, Wong F, Stanley EF. Transmitter release face Ca2+ channel clusters persist at isolated presynaptic terminals. The European Journal of Neuroscience. 23: 1391-6. PMID 16553800 DOI: 10.1111/j.1460-9568.2006.04653.x  0.92
2006 Khanna R, Sun L, Li Q, Guo L, Stanley EF. Long splice variant N type calcium channels are clustered at presynaptic transmitter release sites without modular adaptor proteins. Neuroscience. 138: 1115-25. PMID 16473471 DOI: 10.1016/j.neuroscience.2005.12.050  0.92
2005 Wan J, Khanna R, Sandusky M, Papazian DM, Jen JC, Baloh RW. CACNA1A mutations causing episodic and progressive ataxia alter channel trafficking and kinetics. Neurology. 64: 2090-7. PMID 15985579 DOI: 10.1212/01.WNL.0000167409.59089.C0  0.92
2004 Myers MP, Khanna R, Lee EJ, Papazian DM. Voltage sensor mutations differentially target misfolded K+ channel subunits to proteasomal and non-proteasomal disposal pathways. Febs Letters. 568: 110-6. PMID 15196930 DOI: 10.1016/j.febslet.2004.05.023  0.92
2004 Khanna R, Lee EJ, Papazian DM. Transient calnexin interaction confers long-term stability on folded K+ channel protein in the ER. Journal of Cell Science. 117: 2897-908. PMID 15161937 DOI: 10.1242/jcs.01141  0.92
2003 Koni PA, Khanna R, Chang MC, Tang MD, Kaczmarek LK, Schlichter LC, Flavella RA. Compensatory anion currents in Kv1.3 channel-deficient thymocytes. The Journal of Biological Chemistry. 278: 39443-51. PMID 12878608 DOI: 10.1074/jbc.M304879200  0.92
2001 Joiner WJ, Khanna R, Schlichter LC, Kaczmarek LK. Calmodulin regulates assembly and trafficking of SK4/IK1 Ca2+-activated K+ channels. The Journal of Biological Chemistry. 276: 37980-5. PMID 11495911 DOI: 10.1074/jbc.M104965200  0.92
2001 Khanna R, Myers MP, Lainé M, Papazian DM. Glycosylation increases potassium channel stability and surface expression in mammalian cells. The Journal of Biological Chemistry. 276: 34028-34. PMID 11427541 DOI: 10.1074/jbc.M105248200  0.92
2001 Chang MC, Khanna R, Schlichter LC. Regulation of Kv1.3 channels in activated human T lymphocytes by Ca(2+)-dependent pathways. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 11: 123-34. PMID 11410708 DOI: 10.1159/000047800  0.92
2001 Khanna R, Roy L, Zhu X, Schlichter LC. K+ channels and the microglial respiratory burst. American Journal of Physiology. Cell Physiology. 280: C796-806. PMID 11245596  0.92
2000 Cayabyab FS, Khanna R, Jones OT, Schlichter LC. Suppression of the rat microglia Kv1.3 current by src-family tyrosine kinases and oxygen/glucose deprivation. The European Journal of Neuroscience. 12: 1949-60. PMID 10886336 DOI: 10.1046/j.1460-9568.2000.00083.x  0.92
2000 Jugloff DG, Khanna R, Schlichter LC, Jones OT. Internalization of the Kv1.4 potassium channel is suppressed by clustering interactions with PSD-95. The Journal of Biological Chemistry. 275: 1357-64. PMID 10625685 DOI: 10.1074/jbc.275.2.1357  0.92
1999 Khanna R, Chang MC, Joiner WJ, Kaczmarek LK, Schlichter LC. hSK4/hIK1, a calmodulin-binding KCa channel in human T lymphocytes. Roles in proliferation and volume regulation. The Journal of Biological Chemistry. 274: 14838-49. PMID 10329683 DOI: 10.1074/jbc.274.21.14838  0.92
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