Jie Shen - Publications

Harvard Medical School, Boston, MA, United States 
Molecular Basis of Alzheimer’s Disease and Parkinson’s Disease

76 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Lee SH, Kang J, Ho A, Watanabe H, Bolshakov VY, Shen J. APP Family Regulates Neuronal Excitability and Synaptic Plasticity but Not Neuronal Survival. Neuron. PMID 32891188 DOI: 10.1016/J.Neuron.2020.08.011  0.33
2018 Dhaliwal J, Kannangara TS, Vaculik M, Xue Y, Kumar KL, Maione A, Béïque JC, Shen J, Lagace DC. Adult hippocampal neurogenesis occurs in the absence of Presenilin 1 and Presenilin 2. Scientific Reports. 8: 17931. PMID 30560948 DOI: 10.1038/S41598-018-36363-7  0.325
2017 Parra-Damas A, Rubió-Ferrarons L, Shen J, Saura CA. CRTC1 mediates preferential transcription at neuronal activity-regulated CRE/TATA promoters. Scientific Reports. 7: 18004. PMID 29269871 DOI: 10.1038/S41598-017-18215-Y  0.303
2017 Watanabe H, Shen J. Dominant negative mechanism of Presenilin-1 mutations in FAD. Proceedings of the National Academy of Sciences of the United States of America. PMID 29142009 DOI: 10.1073/Pnas.1717180114  0.325
2017 Giaime E, Tong Y, Wagner LK, Yuan Y, Huang G, Shen J. Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice. Neuron. PMID 29056298 DOI: 10.1016/J.Neuron.2017.09.036  0.37
2017 Kelleher RJ, Shen J. Presenilin-1 mutations and Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 28082723 DOI: 10.1073/Pnas.1619574114  0.331
2016 Xia D, Kelleher RJ, Shen J. Loss of Aβ43 Production Caused by Presenilin-1 Mutations in the Knockin Mouse Brain. Neuron. 90: 417-422. PMID 27100200 DOI: 10.1016/J.Neuron.2016.03.009  0.349
2015 Xia D, Watanabe H, Wu B, Lee SH, Li Y, Tsvetkov E, Bolshakov VY, Shen J, Kelleher RJ. Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease. Neuron. 85: 967-81. PMID 25741723 DOI: 10.1016/J.Neuron.2015.02.010  0.372
2014 Watanabe H, Iqbal M, Zheng J, Wines-Samuelson M, Shen J. Partial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 15912-22. PMID 25429133 DOI: 10.1523/Jneurosci.3261-14.2014  0.362
2014 Grimm MO, Hundsdörfer B, Grösgen S, Mett J, Zimmer VC, Stahlmann CP, Haupenthal VJ, Rothhaar TL, Lehmann J, Pätzold A, Zinser EG, Tanila H, Shen J, Müller U, Grimm HS, et al. PS dependent APP cleavage regulates glucosylceramide synthase and is affected in Alzheimer's disease. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 34: 92-110. PMID 24977484 DOI: 10.1159/000362987  0.353
2014 Lee SH, Sharma M, Südhof TC, Shen J. Synaptic function of nicastrin in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. 111: 8973-8. PMID 24889619 DOI: 10.1073/Pnas.1408554111  0.351
2014 Madeo G, Schirinzi T, Martella G, Latagliata EC, Puglisi F, Shen J, Valente EM, Federici M, Mercuri NB, Puglisi-Allegra S, Bonsi P, Pisani A. PINK1 heterozygous mutations induce subtle alterations in dopamine-dependent synaptic plasticity. Movement Disorders : Official Journal of the Movement Disorder Society. 29: 41-53. PMID 24167038 DOI: 10.1002/Mds.25724  0.351
2013 Shen J. Function and dysfunction of presenilin. Neurodegenerative Diseases. 13: 61-63. PMID 24107444 DOI: 10.1159/000354971  0.386
2013 Wu B, Yamaguchi H, Lai FA, Shen J. Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. 110: 15091-6. PMID 23918386 DOI: 10.1073/Pnas.1304171110  0.332
2013 Heilig EA, Gutti U, Tai T, Shen J, Kelleher RJ. Trans-dominant negative effects of pathogenic PSEN1 mutations on γ-secretase activity and Aβ production. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 11606-17. PMID 23843529 DOI: 10.1523/Jneurosci.0954-13.2013  0.317
2013 Yamaguchi H, Shen J. Histological analysis of neurodegeneration in the mouse brain. Methods of Molecular Biology. 1004: 91-113. PMID 23733572 DOI: 10.1007/978-1-62703-383-1_8  0.343
2013 Matsui H, Gavinio R, Asano T, Uemura N, Ito H, Taniguchi Y, Kobayashi Y, Maki T, Shen J, Takeda S, Uemura K, Yamakado H, Takahashi R. PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates. Human Molecular Genetics. 22: 2423-34. PMID 23449626 DOI: 10.1093/Hmg/Ddt095  0.355
2013 Giaime E, Shen J. Regulation of mitochondrial function by PINK1, Parkin and DJ-1 Molecular Neurodegeneration. 8: 1-1. DOI: 10.1186/1750-1326-8-S1-O13  0.305
2013 Shen J. Function and dysfunction of presenilin in Alzheimer’s disease Molecular Neurodegeneration. 8: 1-1. DOI: 10.1186/1750-1326-8-S1-O11  0.39
2012 Tong Y, Shen J. Genetic analysis of Parkinson's disease-linked leucine-rich repeat kinase 2. Biochemical Society Transactions. 40: 1042-6. PMID 22988862 DOI: 10.1042/Bst20120112  0.345
2012 Joselin AP, Hewitt SJ, Callaghan SM, Kim RH, Chung YH, Mak TW, Shen J, Slack RS, Park DS. ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons. Human Molecular Genetics. 21: 4888-903. PMID 22872702 DOI: 10.1093/Hmg/Dds325  0.355
2012 Gautier CA, Giaime E, Caballero E, Núñez L, Song Z, Chan D, Villalobos C, Shen J. Regulation of mitochondrial permeability transition pore by PINK1. Molecular Neurodegeneration. 7: 22. PMID 22630785 DOI: 10.1186/1750-1326-7-22  0.321
2012 Haque ME, Mount MP, Safarpour F, Abdel-Messih E, Callaghan S, Mazerolle C, Kitada T, Slack RS, Wallace V, Shen J, Anisman H, Park DS. Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1. The Journal of Biological Chemistry. 287: 23162-70. PMID 22511790 DOI: 10.1074/Jbc.M112.346437  0.364
2012 Zheng J, Watanabe H, Wines-Samuelson M, Zhao H, Gridley T, Kopan R, Shen J. Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins. The Journal of Biological Chemistry. 287: 20356-68. PMID 22505716 DOI: 10.1074/Jbc.M112.349738  0.341
2012 Watanabe H, Xia D, Kanekiyo T, Kelleher RJ, Shen J. Familial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 5085-96. PMID 22496554 DOI: 10.1523/Jneurosci.0317-12.2012  0.327
2012 Shen J. Presenilins in Alzheimer’s disease and frontotemporal dementia Molecular Neurodegeneration. 7: 1-1. DOI: 10.1186/1750-1326-7-S1-L8  0.329
2012 Zheng J, Watanabe H, Wines-Samuelson M, Zhao H, Gridley T, Kopan R, Shen J. Reply to Gaiano et al.: Expression of notch proteins in pyramidal neurons in vivo Journal of Biological Chemistry. 287: 24596. DOI: 10.1074/Jbc.L112.380915  0.31
2011 Diedrich M, Kitada T, Nebrich G, Koppelstaetter A, Shen J, Zabel C, Klose J, Mao L. Brain region specific mitophagy capacity could contribute to selective neuronal vulnerability in Parkinson's disease. Proteome Science. 9: 59. PMID 21943346 DOI: 10.1186/1477-5956-9-59  0.332
2011 Ho A, Shen J. Presenilins in synaptic function and disease. Trends in Molecular Medicine. 17: 617-24. PMID 21795114 DOI: 10.1016/J.Molmed.2011.06.002  0.354
2010 Kelleher RJ, Shen J. Genetics. Gamma-secretase and human disease. Science (New York, N.Y.). 330: 1055-6. PMID 21097925 DOI: 10.1126/Science.1198668  0.361
2010 Chen G, Zou X, Watanabe H, van Deursen JM, Shen J. CREB binding protein is required for both short-term and long-term memory formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13066-77. PMID 20881124 DOI: 10.1523/Jneurosci.2378-10.2010  0.311
2010 Heilig EA, Xia W, Shen J, Kelleher RJ. A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity. The Journal of Biological Chemistry. 285: 22350-9. PMID 20460383 DOI: 10.1074/Jbc.M110.116962  0.331
2010 Tong Y, Yamaguchi H, Giaime E, Boyle S, Kopan R, Kelleher RJ, Shen J. Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proceedings of the National Academy of Sciences of the United States of America. 107: 9879-84. PMID 20457918 DOI: 10.1073/Pnas.1004676107  0.359
2010 Wines-Samuelson M, Schulte EC, Smith MJ, Aoki C, Liu X, Kelleher RJ, Shen J. Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice. Plos One. 5: e10195. PMID 20419112 DOI: 10.1371/Journal.Pone.0010195  0.347
2010 Shen J. Impaired Neurotransmitter Release in Alzheimer's and Parkinson's Diseases Neurodegenerative Diseases. 7: 80-83. PMID 20173332 DOI: 10.1159/000285511  0.341
2010 Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, Shen J, Cookson MR, Youle RJ. PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. Plos Biology. 8: e1000298. PMID 20126261 DOI: 10.1371/Journal.Pbio.1000298  0.307
2009 Yang Y, Kim AH, Yamada T, Wu B, Bilimoria PM, Ikeuchi Y, de la Iglesia N, Shen J, Bonni A. A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science (New York, N.Y.). 326: 575-8. PMID 19900895 DOI: 10.1126/Science.1177087  0.322
2009 da Costa CA, Sunyach C, Giaime E, West A, Corti O, Brice A, Safe S, Abou-Sleiman PM, Wood NW, Takahashi H, Goldberg MS, Shen J, Checler F. Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease. Nature Cell Biology. 11: 1370-5. PMID 19801972 DOI: 10.1038/Ncb1981  0.328
2009 Aoki C, Lee J, Nedelescu H, Ahmed T, Ho A, Shen J. Increased levels of NMDA receptor NR2A subunits at pre- and postsynaptic sites of the hippocampal CA1: an early response to conditional double knockout of presenilin 1 and 2. The Journal of Comparative Neurology. 517: 512-23. PMID 19795494 DOI: 10.1002/Cne.22151  0.318
2009 Kitada T, Tong Y, Gautier CA, Shen J. Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice. Journal of Neurochemistry. 111: 696-702. PMID 19694908 DOI: 10.1111/J.1471-4159.2009.06350.X  0.365
2009 Tong Y, Pisani A, Martella G, Karouani M, Yamaguchi H, Pothos EN, Shen J. R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 14622-7. PMID 19667187 DOI: 10.1073/Pnas.0906334106  0.347
2009 Zhang C, Wu B, Beglopoulos V, Wines-Samuelson M, Zhang D, Dragatsis I, Südhof TC, Shen J. Presenilins are essential for regulating neurotransmitter release. Nature. 460: 632-6. PMID 19641596 DOI: 10.1038/Nature08177  0.308
2009 Tabuchi K, Chen G, Südhof TC, Shen J. Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 7290-301. PMID 19494151 DOI: 10.1523/Jneurosci.1320-09.2009  0.345
2009 Kitada T, Pisani A, Karouani M, Haburcak M, Martella G, Tscherter A, Platania P, Wu B, Pothos EN, Shen J. Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice. Journal of Neurochemistry. 110: 613-21. PMID 19457102 DOI: 10.1111/J.1471-4159.2009.06152.X  0.327
2009 Watanabe H, Smith MJ, Heilig E, Beglopoulos V, Kelleher RJ, Shen J. Indirect regulation of presenilins in CREB-mediated transcription. The Journal of Biological Chemistry. 284: 13705-13. PMID 19289467 DOI: 10.1074/Jbc.M809168200  0.356
2009 Baulac S, Lu H, Strahle J, Yang T, Goldberg MS, Shen J, Schlossmacher MG, Lemere CA, Lu Q, Xia W. Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains. Molecular Neurodegeneration. 4: 12. PMID 19243613 DOI: 10.1186/1750-1326-4-12  0.33
2009 Martella G, Platania P, Vita D, Sciamanna G, Cuomo D, Tassone A, Tscherter A, Kitada T, Bonsi P, Shen J, Pisani A. Enhanced sensitivity to group II mGlu receptor activation at corticostriatal synapses in mice lacking the familial parkinsonism-linked genes PINK1 or Parkin. Experimental Neurology. 215: 388-96. PMID 19071114 DOI: 10.1016/J.Expneurol.2008.11.001  0.319
2008 Hashimoto-Torii K, Torii M, Sarkisian MR, Bartley CM, Shen J, Radtke F, Gridley T, Sestan N, Rakic P. Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex. Neuron. 60: 273-84. PMID 18957219 DOI: 10.1016/J.Neuron.2008.09.026  0.317
2008 Gautier CA, Kitada T, Shen J. Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. 105: 11364-9. PMID 18687901 DOI: 10.1073/Pnas.0802076105  0.337
2008 Kim WY, Shen J. Presenilins are required for maintenance of neural stem cells in the developing brain Molecular Neurodegeneration. 3. DOI: 10.1186/1750-1326-3-2  0.324
2007 Cookson MR, Dauer W, Dawson T, Fon EA, Guo M, Shen J. The roles of kinases in familial Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 11865-8. PMID 17978026 DOI: 10.1523/Jneurosci.3695-07.2007  0.335
2007 Kitada T, Pisani A, Porter DR, Yamaguchi H, Tscherter A, Martella G, Bonsi P, Zhang C, Pothos EN, Shen J. Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 104: 11441-6. PMID 17563363 DOI: 10.1073/Pnas.0702717104  0.317
2007 Yamaguchi H, Shen J. Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice. Molecular Neurodegeneration. 2: 10-10. PMID 17535435 DOI: 10.1186/1750-1326-2-10  0.365
2007 Shen J, Kelleher RJ. The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism. Proceedings of the National Academy of Sciences of the United States of America. 104: 403-9. PMID 17197420 DOI: 10.1073/Pnas.0608332104  0.336
2006 Rosen KM, Veereshwarayya V, Moussa CE, Fu Q, Goldberg MS, Schlossmacher MG, Shen J, Querfurth HW. Parkin protects against mitochondrial toxins and beta-amyloid accumulation in skeletal muscle cells. The Journal of Biological Chemistry. 281: 12809-16. PMID 16517603 DOI: 10.1074/Jbc.M512649200  0.3
2006 Beglopoulos V, Shen J. Regulation of CRE-dependent transcription by presenilins: prospects for therapy of Alzheimer's disease Trends in Pharmacological Sciences. 27: 33-40. PMID 16337694 DOI: 10.1016/J.Tips.2005.11.010  0.34
2006 Yang X, Handler M, Shen J. Role of presenilin-1 in murine neural development. Annals of the New York Academy of Sciences. 920: 165-170. PMID 11193146 DOI: 10.1111/J.1749-6632.2000.Tb06918.X  0.323
2006 Beglopoulos V, Saura C, Shen J. Neuropathology and reduced CREB/CBP signaling in presenilin conditional knockout mice: Prospects for therapy of Alzheimer's disease Annals of General Psychiatry. 5: 1-1. DOI: 10.1186/1744-859X-5-S1-S233  0.352
2005 Sun X, Beglopoulos V, Mattson MP, Shen J. Hippocampal spatial memory impairments caused by the familial Alzheimer's disease-linked presenilin 1 M146V mutation. Neuro-Degenerative Diseases. 2: 6-15. PMID 16908998 DOI: 10.1159/000086426  0.344
2005 Wines-Samuelson M, Shen J. Presenilins in the Developing, Adult, and Aging Cerebral Cortex The Neuroscientist. 11: 441-451. PMID 16151045 DOI: 10.1177/1073858405278922  0.348
2005 Saura CA, Chen G, Malkani S, Choi SY, Takahashi RH, Zhang D, Gouras GK, Kirkwood A, Morris RG, Shen J. Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 6755-64. PMID 16033885 DOI: 10.1523/Jneurosci.1247-05.2005  0.33
2005 Zhang L, Lee J, Song L, Sun X, Shen J, Terracina G, Parker EM. Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nicastrin [correction of nacastrin], aph-1a, and pen-2. Biochemistry. 44: 4450-7. PMID 15766275 DOI: 10.1021/Bi0481500  0.308
2005 Goldberg MS, Pisani A, Haburcak M, Vortherms TA, Kitada T, Costa C, Tong Y, Martella G, Tscherter A, Martins A, Bernardi G, Roth BL, Pothos EN, Calabresi P, Shen J. Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron. 45: 489-96. PMID 15721235 DOI: 10.1016/J.Neuron.2005.01.041  0.353
2005 Wines-Samuelson M, Handler M, Shen J. Role of presenilin-1 in cortical lamination and survival of Cajal-Retzius neurons. Developmental Biology. 277: 332-346. PMID 15617678 DOI: 10.1016/J.Ydbio.2004.09.024  0.343
2004 Beglopoulos V, Shen J. Gene-targeting technologies for the study of neurological disorders. Neuromolecular Medicine. 6: 13-30. PMID 15781974 DOI: 10.1385/Nmm:6:1:013  0.314
2004 Beglopoulos V, Sun X, Saura CA, Lemere CA, Kim RD, Shen J. Reduced β-Amyloid Production and Increased Inflammatory Responses in Presenilin Conditional Knock-out Mice Journal of Biological Chemistry. 279: 46907-46914. PMID 15345711 DOI: 10.1074/Jbc.M409544200  0.368
2004 Shen J, Cookson MR. Mitochondria and dopamine: new insights into recessive parkinsonism. Neuron. 43: 301-4. PMID 15294138 DOI: 10.1016/J.Neuron.2004.07.012  0.348
2004 Yang X, Klein R, Tian X, Cheng HT, Kopan R, Shen J. Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Developmental Biology. 269: 81-94. PMID 15081359 DOI: 10.1016/J.Ydbio.2004.01.014  0.321
2004 Saura CA, Choi SY, Beglopoulos V, Malkani S, Zhang D, Shankaranarayana Rao BS, Chattarji S, Kelleher RJ, Kandel ER, Duff K, Kirkwood A, Shen J. Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron. 42: 23-36. PMID 15066262 DOI: 10.1016/S0896-6273(04)00182-5  0.345
2004 Palacino JJ, Sagi D, Goldberg MS, Krauss S, Motz C, Wacker M, Klose J, Shen J. Mitochondrial dysfunction and oxidative damage in parkin-deficient mice. The Journal of Biological Chemistry. 279: 18614-22. PMID 14985362 DOI: 10.1074/Jbc.M401135200  0.35
2003 Goldberg MS, Fleming SM, Palacino JJ, Cepeda C, Lam HA, Bhatnagar A, Meloni EG, Wu N, Ackerson LC, Klapstein GJ, Gajendiran M, Roth BL, Chesselet MF, Maidment NT, Levine MS, ... Shen J, et al. Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. The Journal of Biological Chemistry. 278: 43628-35. PMID 12930822 DOI: 10.1074/Jbc.M308947200  0.394
2001 Yu H, Saura CA, Choi SY, Sun LD, Yang X, Handler M, Kawarabayashi T, Younkin L, Fedeles B, Wilson MA, Younkin S, Kandel ER, Kirkwood A, Shen J. APP processing and synaptic plasticity in presenilin-1 conditional knockout mice. Neuron. 31: 713-26. PMID 11567612 DOI: 10.1016/S0896-6273(01)00417-2  0.334
2000 Yoo AS, Cheng I, Chung S, Grenfell TZ, Lee H, Pack-Chung E, Handler M, Shen J, Xia W, Tesco G, Saunders AJ, Ding K, Frosch MP, Tanzi RE, Kim TW. Presenilin-mediated modulation of capacitative calcium entry. Neuron. 27: 561-72. PMID 11055438 DOI: 10.1016/S0896-6273(00)00066-0  0.317
1999 Berezovska O, Frosch M, McLean P, Knowles R, Koo E, Kang D, Shen J, Lu FM, Lux SE, Tonegawa S, Hyman BT. The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons. Brain Research. Molecular Brain Research. 69: 273-80. PMID 10366748 DOI: 10.1016/S0169-328X(99)00119-9  0.36
1998 Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi. Biochemistry. 37: 16465-71. PMID 9843412 DOI: 10.1021/Bi9816195  0.31
1997 Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S. Skeletal and CNS defects in Presenilin-1-deficient mice. Cell. 89: 629-39. PMID 9160754 DOI: 10.1016/S0092-8674(00)80244-5  0.37
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