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Blair Leavitt - Publications

Affiliations: 
University of British Columbia, Vancouver, Vancouver, BC, Canada 
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33/384 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Estevez-Fraga C, Altmann A, Parker CS, Scahill RI, Costa B, Chen Z, Manzoni C, Zarkali A, Durr A, Roos RAC, Landwehrmeyer B, Leavitt BR, Rees G, Tabrizi SJ, McColgan P. Genetic topography and cortical cell loss in Huntington's disease link development and neurodegeneration. Brain : a Journal of Neurology. PMID 37587097 DOI: 10.1093/brain/awad275  0.306
2021 Galvan A, Petkau TL, Hill AM, Korecki AJ, Lu G, Choi D, Rahman K, Simpson E, Leavitt BR, Smith Y. Intracerebroventricular Administration of AAV9-PHP.B SYN1-EmGFP Induces Widespread Transgene Expression in the Mouse and Monkey CNS. Human Gene Therapy. PMID 33860682 DOI: 10.1089/hum.2020.301  0.351
2017 Petkau TL, Kosior N, de Asis K, Connolly C, Leavitt BR. Selective depletion of microglial progranulin in mice is not sufficient to cause neuronal ceroid lipofuscinosis or neuroinflammation. Journal of Neuroinflammation. 14: 225. PMID 29149899 DOI: 10.1186/s12974-017-1000-9  0.362
2017 Petkau TL, Blanco J, Leavitt BR. Conditional loss of progranulin in neurons is not sufficient to cause neuronal ceroid lipofuscinosis-like neuropathology in mice. Neurobiology of Disease. 106: 14-22. PMID 28647554 DOI: 10.1016/j.nbd.2017.06.012  0.403
2016 Wagner L, Björkqvist M, Hult Lundh S, Wolf R, Börgel A, Schlenzig D, Ludwig HH, Rahfeld JU, Leavitt B, Demuth HU, Petersén Å, von Hörsten S. Neuropeptide Y (NPY) in cerebrospinal fluid from patients with Huntington's Disease: increased NPY levels and differential degradation of the NPY1-30 fragment. Journal of Neurochemistry. PMID 27016395 DOI: 10.1111/Jnc.13624  0.302
2014 Petkau T, Russell-Schulz B, Sturrock A, Hutchinson J, Coleman A, Decolongon J, Hayden, Tabrizi S, Mackay A, Leavitt B. E32 A 36 Month Longitudinal Magnetic Resonance Spectroscopy Study In Pre-manifest And Early Huntington Disease Subjects From The Track-hd Study Journal of Neurology, Neurosurgery, and Psychiatry. 85. DOI: 10.1136/Jnnp-2014-309032.135  0.316
2014 Gregory S, Scahill R, Durr A, Leavitt B, Roos R, Johnson H, Langbehn, Rees G, Tabrizi S. Structural Connectivity In Huntington'S Disease Journal of Neurology, Neurosurgery, and Psychiatry. 85. DOI: 10.1136/Jnnp-2014-309032.118  0.311
2013 Petkau TL, Zhu S, Lu G, Fernando S, Cynader M, Leavitt BR. Sensitivity to neurotoxic stress is not increased in progranulin-deficient mice. Neurobiology of Aging. 34: 2548-50. PMID 23702345 DOI: 10.1016/J.Neurobiolaging.2013.04.019  0.336
2012 Crawford H, Hobbs N, Cole J, Rees E, Owen G, Langbehn, Frost C, Landwehrmeyer B, Reilmann R, Craufurd D, Stout J, Durr A, Leavitt B, Roos R, Tabrizi S, et al. Corpus Callosal Atrophy In Huntington'S Disease Journal of Neurology, Neurosurgery, and Psychiatry. 83. DOI: 10.1136/Jnnp-2012-303524.83  0.303
2010 Petkau TL, Neal SJ, Orban PC, MacDonald JL, Hill AM, Lu G, Feldman HH, Mackenzie IR, Leavitt BR. Progranulin expression in the developing and adult murine brain. The Journal of Comparative Neurology. 518: 3931-47. PMID 20737593 DOI: 10.1002/cne.22430  0.582
2009 Joshi PR, Wu NP, André VM, Cummings DM, Cepeda C, Joyce JA, Carroll JB, Leavitt BR, Hayden MR, Levine MS, Bamford NS. Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 2414-27. PMID 19244517 DOI: 10.1523/Jneurosci.5687-08.2009  0.31
2009 Graham RK, Pouladi MA, Joshi P, Lu G, Deng Y, Wu NP, Figueroa BE, Metzler M, André VM, Slow EJ, Raymond L, Friedlander R, Levine MS, Leavitt BR, Hayden MR. Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 2193-204. PMID 19228972 DOI: 10.1523/Jneurosci.5473-08.2009  0.334
2007 Van Raamsdonk JM, Murphy Z, Selva DM, Hamidizadeh R, Pearson J, Petersén A, Björkqvist M, Muir C, Mackenzie IR, Hammond GL, Vogl AW, Hayden MR, Leavitt BR. Testicular degeneration in Huntington disease. Neurobiology of Disease. 26: 512-20. PMID 17433700 DOI: 10.1016/J.Nbd.2007.01.006  0.324
2006 Devon RS, Orban PC, Gerrow K, Barbieri MA, Schwab C, Cao LP, Helm JR, Bissada N, Cruz-Aguado R, Davidson TL, Witmer J, Metzler M, Lam CK, Tetzlaff W, Simpson EM, ... ... Leavitt BR, et al. Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities. Proceedings of the National Academy of Sciences of the United States of America. 103: 9595-600. PMID 16769894 DOI: 10.1073/Pnas.0510197103  0.323
2006 Leavitt BR, van Raamsdonk JM, Shehadeh J, Fernandes H, Murphy Z, Graham RK, Wellington CL, Raymond LA, Hayden MR. Wild-type huntingtin protects neurons from excitotoxicity. Journal of Neurochemistry. 96: 1121-9. PMID 16417581 DOI: 10.1111/J.1471-4159.2005.03605.X  0.355
2005 Van Raamsdonk JM, Pearson J, Bailey CD, Rogers DA, Johnson GV, Hayden MR, Leavitt BR. Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease. Journal of Neurochemistry. 95: 210-20. PMID 16181425 DOI: 10.1111/J.1471-4159.2005.03357.X  0.347
2005 Jenkins BG, Andreassen OA, Dedeoglu A, Leavitt B, Hayden M, Borchelt D, Ross CA, Ferrante RJ, Beal MF. Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease. Journal of Neurochemistry. 95: 553-62. PMID 16135087 DOI: 10.1111/J.1471-4159.2005.03411.X  0.321
2005 Slow EJ, Graham RK, Osmand AP, Devon RS, Lu G, Deng Y, Pearson J, Vaid K, Bissada N, Wetzel R, Leavitt BR, Hayden MR. Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions. Proceedings of the National Academy of Sciences of the United States of America. 102: 11402-7. PMID 16076956 DOI: 10.1073/Pnas.0503634102  0.404
2005 Devon RS, Schwab C, Topp JD, Orban PC, Yang YZ, Pape TD, Helm JR, Davidson TL, Rogers DA, Gros-Louis F, Rouleau G, Horazdovsky BF, Leavitt BR, Hayden MR. Cross-species characterization of the ALS2 gene and analysis of its pattern of expression in development and adulthood. Neurobiology of Disease. 18: 243-57. PMID 15686953 DOI: 10.1016/J.Nbd.2004.10.002  0.322
2004 Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, et al. Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease. Cell Death and Differentiation. 11: 424-38. PMID 14713958 DOI: 10.1038/Sj.Cdd.4401358  0.33
2003 Zuccato C, Tartari M, Crotti A, Goffredo D, Valenza M, Conti L, Cataudella T, Leavitt BR, Hayden MR, Timmusk T, Rigamonti D, Cattaneo E. Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nature Genetics. 35: 76-83. PMID 12881722 DOI: 10.1038/Ng1219  0.332
2003 Slow EJ, van Raamsdonk J, Rogers D, Coleman SH, Graham RK, Deng Y, Oh R, Bissada N, Hossain SM, Yang YZ, Li XJ, Simpson EM, Gutekunst CA, Leavitt BR, Hayden MR. Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease. Human Molecular Genetics. 12: 1555-67. PMID 12812983 DOI: 10.1093/Hmg/Ddg169  0.309
2003 Wellington CL, Ellerby LM, Leavitt BR, Roy S, Nicholson DW, Hayden MR. Huntington proteolysis in Huntington disease Clinical Neuroscience Research. 3: 129-139. DOI: 10.1016/S1566-2772(03)00055-0  0.308
2002 Zeron MM, Hansson O, Chen N, Wellington CL, Leavitt BR, Brundin P, Hayden MR, Raymond LA. Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease. Neuron. 33: 849-60. PMID 11906693 DOI: 10.1016/S0896-6273(02)00615-3  0.326
2001 Zuccato C, Ciammola A, Rigamonti D, Leavitt BR, Goffredo D, Conti L, MacDonald ME, Friedlander RM, Silani V, Hayden MR, Timmusk T, Sipione S, Cattaneo E. Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease. Science (New York, N.Y.). 293: 493-8. PMID 11408619 DOI: 10.1126/Science.1059581  0.369
2001 Clarke G, Collins RA, Leavitt BR, Andrews DF, Hayden MR, Lumsden CJ, McInnes RR. addendum: A one-hit model of cell death in inherited neuronal degenerations Nature. 409: 542-542. DOI: 10.1038/35054107  0.328
2000 Wellington CL, Leavitt BR, Hayden MR. Huntington disease: new insights on the role of huntingtin cleavage. Journal of Neural Transmission. Supplementum. 1-17. PMID 11128600 DOI: 10.1007/978-3-7091-6284-2_1  0.343
2000 Shin JJ, Fricker-Gates RA, Perez FA, Leavitt BR, Zurakowski D, Macklis JD. Transplanted neuroblasts differentiate appropriately into projection neurons with correct neurotransmitter and receptor phenotype in neocortex undergoing targeted projection neuron degeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 7404-16. PMID 11007899 DOI: 10.1523/Jneurosci.20-19-07404.2000  0.771
2000 Clarke G, Collins RA, Leavitt BR, Andrews DF, Hayden MR, Lumsden CJ, McInnes RR. A one-hit model of cell death in inherited neuronal degenerations. Nature. 406: 195-9. PMID 10910361 DOI: 10.1038/35018098  0.315
2000 Magavi SS, Leavitt BR, Macklis JD. Induction of neurogenesis in the neocortex of adult mice. Nature. 405: 951-5. PMID 10879536 DOI: 10.1038/35016083  0.769
1999 Catapano LA, Sheen VL, Leavitt BR, Macklis JD. Differentiation of transplanted neural precursors varies regionally in adults striatum. Neuroreport. 10: 3971-7. PMID 10716243 DOI: 10.1097/00001756-199912160-00045  0.711
1999 Hodgson JG, Agopyan N, Gutekunst CA, Leavitt BR, LePiane F, Singaraja R, Smith DJ, Bissada N, McCutcheon K, Nasir J, Jamot L, Li XJ, Stevens ME, Rosemond E, Roder JC, et al. A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration. Neuron. 23: 181-92. PMID 10402204 DOI: 10.1016/S0896-6273(00)80764-3  0.311
1999 Leavitt BR, Hernit-Grant CS, Macklis JD. Mature astrocytes transform into transitional radial glia within adult mouse neocortex that supports directed migration of transplanted immature neurons. Experimental Neurology. 157: 43-57. PMID 10222107 DOI: 10.1006/exnr.1999.6982  0.617
Low-probability matches (unlikely to be authored by this person)
2014 Gregory S, Scahill R, Stopford C, Orth M, Durr A, Leavitt B, Roos R, Langbehn D, Johnson H, Rees G, Tabrizi S, Craufurd D. E16 Diffusion Tensor Imaging And Neuropsychiatric Disturbance In Huntington ’s Disease Journal of Neurology, Neurosurgery, and Psychiatry. 85. DOI: 10.1136/Jnnp-2014-309032.119  0.298
2010 Metzler M, Gan L, Mazarei G, Graham RK, Liu L, Bissada N, Lu G, Leavitt BR, Hayden MR. Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 14318-29. PMID 20980587 DOI: 10.1523/Jneurosci.1589-10.2010  0.295
2009 Say M, Bechtel N, Sturrock A, van den Bogaard S, Jauffret C, Bohlen S, Langbehn D, Mills J, Archarya T, Johnson H, Borowsky B, Durr A, Leavitt B, Roos R, Tabrizi S, et al. Quantitative motor phenotype assessment in pre-manifest and symptomatic Huntington's disease: tongue force analysis differentiates between disease stages and provides high phenotype correlation. Cross sectional results from the TRACK-HD Study Aktuelle Neurologie. 36. DOI: 10.1055/S-0029-1238518  0.292
2003 Li L, Fan M, Icton CD, Chen N, Leavitt BR, Hayden MR, Murphy TH, Raymond LA. Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease. Neurobiology of Aging. 24: 1113-21. PMID 14643383 DOI: 10.1016/J.Neurobiolaging.2003.04.003  0.29
2019 Leavitt B, Tabrizi S, Ducray PS, Wild E, Schlegel V, Hooper G, Nicotra A, Chevure J, Smith A, Lane R, Bennett F, Boak L, Doody R, Schobel S. A safety, tolerability and biomarker update from an ongoing open-label extension study of RG6042 in adults with early manifest Huntington’s disease Journal of the Neurological Sciences. 405: 26-27. DOI: 10.1016/J.Jns.2019.10.260  0.29
2016 Wiecki TV, Antoniades CA, Stevenson A, Kennard C, Borowsky B, Owen G, Leavitt B, Roos R, Durr A, Tabrizi SJ, Frank MJ. A Computational Cognitive Biomarker for Early-Stage Huntington's Disease. Plos One. 11: e0148409. PMID 26872129 DOI: 10.1371/Journal.Pone.0148409  0.289
2006 Graham RK, Deng Y, Slow EJ, Haigh B, Bissada N, Lu G, Pearson J, Shehadeh J, Bertram L, Murphy Z, Warby SC, Doty CN, Roy S, Wellington CL, Leavitt BR, et al. Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin. Cell. 125: 1179-91. PMID 16777606 DOI: 10.1016/J.Cell.2006.04.026  0.285
2002 Singaraja RR, Hadano S, Metzler M, Givan S, Wellington CL, Warby S, Yanai A, Gutekunst CA, Leavitt BR, Yi H, Fichter K, Gan L, McCutcheon K, Chopra V, Michel J, et al. HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis. Human Molecular Genetics. 11: 2815-28. PMID 12393793 DOI: 10.1093/Hmg/11.23.2815  0.285
2018 Gregory S, Crawford H, Seunarine K, Leavitt B, Durr A, Roos RAC, Scahill RI, Tabrizi SJ, Rees G, Langbehn D, Orth M. Natural biological variation of white matter microstructure is accentuated in Huntington's disease. Human Brain Mapping. PMID 29682858 DOI: 10.1002/Hbm.24191  0.279
2018 Tabrizi SJ, Leavitt B, Landwehrmeyer B, Wild E, Saft C, Barker R, Craufurd D, Rickards H, Rosser A, Priller J, Kordasiewicz H, Czech C, Swayze E, Norris DA, Baumann T, et al. J01 Effects of IONIS-HTTRX (RG6042) in patients with early huntington’s disease, results of the first htt-lowering drug trial Journal of Neurology, Neurosurgery, and Psychiatry. 89. DOI: 10.1136/Jnnp-2018-Ehdn.261  0.279
2010 Mazarei G, Neal SJ, Becanovic K, Luthi-Carter R, Simpson EM, Leavitt BR. Expression analysis of novel striatal-enriched genes in Huntington disease. Human Molecular Genetics. 19: 609-22. PMID 19934114 DOI: 10.1093/hmg/ddp527  0.279
2006 Graham RK, Slow EJ, Deng Y, Bissada N, Lu G, Pearson J, Shehadeh J, Leavitt BR, Raymond LA, Hayden MR. Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models. Neurobiology of Disease. 21: 444-55. PMID 16230019 DOI: 10.1016/J.Nbd.2005.08.007  0.277
2014 Crawford H, Gregory S, Hobbs N, Johnson H, Cole J, Rees E, Malone I, Sprengelmeyer R, Durr A, Leavitt B, Roos R, Langbehn, Landwehrmeyer G, Tabrizi S, Scahill R. Association Between Brain Volume And White Matter Microstructure In Healthy Controls Journal of Neurology, Neurosurgery, and Psychiatry. 85. DOI: 10.1136/Jnnp-2014-309032.114  0.276
2018 Baake V, Coppen EM, van Duijn E, Dumas EM, van den Bogaard SJA, Scahill RI, Johnson H, Leavitt B, Durr A, Tabrizi SJ, Craufurd D, Roos RAC. Apathy and atrophy of subcortical brain structures in Huntington's disease: A two-year follow-up study. Neuroimage. Clinical. 19: 66-70. PMID 30035003 DOI: 10.1016/J.Nicl.2018.03.033  0.276
2014 Leavitt B. A11 Reviewing Progress To Date In HD Journal of Neurology, Neurosurgery & Psychiatry. 85: A4-A4. DOI: 10.1136/JNNP-2014-309032.11  0.274
2014 Johnson E, Rees E, Labuschagne I, Durr A, Leavitt B, Roos R, Johnson H, Hobbs N, Crawford H, Langbehn, Stout J, Tabrizi S, Scahill R. Cortical Thinning Of The Occipital Lobe In Huntington'S Disease And Associations With Cognitive Performance Journal of Neurology, Neurosurgery, and Psychiatry. 85. DOI: 10.1136/Jnnp-2014-309032.107  0.271
2012 Borowsky B, Warner J, Matson W, Johnson H, Durr A, Roos R, Tabrizi S, Leavitt B, Becker C, Tobin A, Schulman H. F14 8OHdG is not a biomarker for Huntington's disease; lessons for future biomarker studies Journal of Neurology, Neurosurgery & Psychiatry. 83: A25.2-A26. DOI: 10.1136/Jnnp-2012-303524.79  0.269
2009 Bechtel N, Jauffret C, Say M, Sturrock A, van den Bogaard S, Mills J, Archarya T, Langbehn D, Johnson H, Borowsky B, Durr A, Leavitt B, Roos R, Stout J, Tabrizi S, et al. Finger tapping as an objective motor phenotype marker in pre-manifest and symptomatic Huntington's disease – cross-sectional results from the TRACK-HD Study Aktuelle Neurologie. 36. DOI: 10.1055/S-0029-1238474  0.263
2005 Van Raamsdonk JM, Murphy Z, Slow EJ, Leavitt BR, Hayden MR. Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease. Human Molecular Genetics. 14: 3823-35. PMID 16278236 DOI: 10.1093/Hmg/Ddi407  0.262
2002 Wellington CL, Ellerby LM, Gutekunst CA, Rogers D, Warby S, Graham RK, Loubser O, van Raamsdonk J, Singaraja R, Yang YZ, Gafni J, Bredesen D, Hersch SM, Leavitt BR, Roy S, et al. Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 7862-72. PMID 12223539 DOI: 10.1523/Jneurosci.22-18-07862.2002  0.261
2013 Boxer AL, Gold M, Huey E, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, et al. Frontotemporal degeneration, the next therapeutic frontier: molecules and animal models for frontotemporal degeneration drug development. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 176-88. PMID 23043900 DOI: 10.1016/J.Jalz.2012.03.002  0.261
2009 Rohm S, Bechtel N, Beckmann H, Sturrock A, van den Bogaard S, Say M, Jauffret C, Mills J, Archarya T, Langbehn D, Johnson H, Borowsky B, Durr A, Leavitt B, Roos R, et al. Sensitivity of gait analysis to detect motor phenotype in pre-manifest and manifest Huntington's disease – cross-sectional results from the TRACK-HD Study Aktuelle Neurologie. 36. DOI: 10.1055/S-0029-1238520  0.258
2006 Mackenzie IR, Butland SL, Devon RS, Dwosh E, Feldman H, Lindholm C, Neal SJ, Ouellette BF, Leavitt BR. Familial frontotemporal dementia with neuronal intranuclear inclusions is not a polyglutamine expansion disease. Bmc Neurology. 6: 32. PMID 16945149 DOI: 10.1186/1471-2377-6-32  0.258
2012 Park KH, Lu G, Fan J, Raymond LA, Leavitt BR. Decreasing Levels of the cdk5 Activators, p25 and p35, Reduces Excitotoxicity in Striatal Neurons. Journal of Huntington's Disease. 1. PMID 24353748 DOI: 10.3233/Jhd-2012-129000  0.253
2018 Rowley CD, Tabrizi SJ, Scahill RI, Leavitt BR, Roos RAC, Durr A, Bock NA. Altered Intracortical T-Weighted/T-Weighted Ratio Signal in Huntington's Disease. Frontiers in Neuroscience. 12: 805. PMID 30455625 DOI: 10.3389/fnins.2018.00805  0.253
2014 Jones R, Stout JC, Labuschagne I, Say M, Justo D, Coleman A, Dumas EM, Hart E, Owen G, Durr A, Leavitt BR, Roos R, O'Regan A, Langbehn D, Tabrizi SJ, et al. The potential of composite cognitive scores for tracking progression in Huntington's disease. Journal of Huntington's Disease. 3: 197-207. PMID 25062862 DOI: 10.1136/Jnnp-2012-303524.113  0.252
2004 Zala D, Bensadoun JC, Pereira de Almeida L, Leavitt BR, Gutekunst CA, Aebischer P, Hayden MR, Déglon N. Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice. Experimental Neurology. 185: 26-35. PMID 14697316 DOI: 10.1016/J.Expneurol.2003.09.002  0.248
2015 Minkova L, Eickhoff SB, Abdulkadir A, Kaller CP, Peter J, Scheller E, Lahr J, Roos RA, Durr A, Leavitt BR, Tabrizi SJ, Klöppel S. Large-scale brain network abnormalities in Huntington's disease revealed by structural covariance. Human Brain Mapping. PMID 26453902 DOI: 10.1002/Hbm.23014  0.247
2010 Evans K, Vaccarino A, Craufurd D, Callaghan J, Durr A, Leavitt B, Roos R, Tabrizi S. Poster 9: The Short Version of the Problem Behaviours Assessment for HD (PBA-s): An Item Response Analysis Using Data from the TRACK-HD Study Neurotherapeutics. 7: 140-140. DOI: 10.1016/J.Nurt.2009.09.011  0.247
2017 Gregory S, Long JD, Klöppel S, Razi A, Scheller E, Minkova L, Papoutsi M, Mills JA, Durr A, Leavitt BR, Roos RA, Stout JC, Scahill RI, Langbehn DR, Tabrizi SJ, et al. Operationalizing compensation over time in neurodegenerative disease. Brain : a Journal of Neurology. PMID 28334888 DOI: 10.1093/Brain/Awx022  0.247
2012 Tang B, Becanovic K, Desplats PA, Spencer B, Hill AM, Connolly C, Masliah E, Leavitt BR, Thomas EA. Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS: implications for transcriptional dysregulation in Huntington disease. Human Molecular Genetics. 21: 3097-111. PMID 22492998 DOI: 10.1093/Hmg/Dds132  0.246
2005 Sivananthan SN, Leavitt BR. Got NGF? Promising gene therapy results in Alzheimer's disease Clinical Genetics. 68: 194-196. DOI: 10.1111/j.1399-0004.2005.0494b.x  0.245
2001 Cepeda C, Ariano MA, Calvert CR, Flores-Hernández J, Chandler SH, Leavitt BR, Hayden MR, Levine MS. NMDA receptor function in mouse models of Huntington disease. Journal of Neuroscience Research. 66: 525-39. PMID 11746372 DOI: 10.1002/Jnr.1244  0.243
2019 Petkau TL, Hill A, Connolly C, Lu G, Wagner P, Kosior N, Blanco J, Leavitt BR. Mutant huntingtin expression in microglia is neither required nor sufficient to cause the Huntington's disease-like phenotype in BACHD mice. Human Molecular Genetics. PMID 30624705 DOI: 10.1093/hmg/ddz009  0.243
2005 Van Raamsdonk JM, Pearson J, Rogers DA, Lu G, Barakauskas VE, Barr AM, Honer WG, Hayden MR, Leavitt BR. Ethyl-EPA treatment improves motor dysfunction, but not neurodegeneration in the YAC128 mouse model of Huntington disease. Experimental Neurology. 196: 266-72. PMID 16129433 DOI: 10.1016/J.Expneurol.2005.07.021  0.242
2016 Connolly C, Magnusson-Lind A, Lu G, Wagner PK, Southwell AL, Hayden MR, Björkqvist M, Leavitt BR. Enhanced Immune Response to MMP3 stimulation in Microglia Expressing Mutant Huntingtin. Neuroscience. PMID 27033979 DOI: 10.1016/J.Neuroscience.2016.03.031  0.237
2015 Klöppel S, Gregory S, Scheller E, Minkova L, Razi A, Durr A, Roos RA, Leavitt BR, Papoutsi M, Landwehrmeyer GB, Reilmann R, Borowsky B, Johnson H, Mills JA, Owen G, et al. Compensation in Preclinical Huntington's Disease: Evidence From the Track-On HD Study. Ebiomedicine. 2: 1420-9. PMID 26629536 DOI: 10.1016/J.Ebiom.2015.08.002  0.237
2011 Fotovati A, Abu-Ali S, Wang PS, Deleyrolle LP, Lee C, Triscott J, Chen JY, Franciosi S, Nakamura Y, Sugita Y, Uchiumi T, Kuwano M, Leavitt BR, Singh SK, Jury A, et al. YB-1 bridges neural stem cells and brain tumor-initiating cells via its roles in differentiation and cell growth. Cancer Research. 71: 5569-78. PMID 21730024 DOI: 10.1158/0008-5472.Can-10-2805  0.231
2016 Frank S, Testa CM, Stamler D, Kayson E, Davis C, Edmondson MC, Kinel S, Leavitt B, Oakes D, O'Neill C, Vaughan C, Goldstein J, Herzog M, Snively V, et al. Effect of Deutetrabenazine on Chorea Among Patients With Huntington Disease: A Randomized Clinical Trial. Jama. 316: 40-50. PMID 27380342 DOI: 10.1001/Jama.2016.8655  0.228
2019 Kosior N, Petkau TL, Connolly C, Lu G, Leavitt BR. Isolating Cells from Adult Murine Brain for Validation of Cell-type Specific Cre-mediated Deletion. Journal of Neuroscience Methods. 108422. PMID 31493416 DOI: 10.1016/j.jneumeth.2019.108422  0.228
2015 Petkau TL, Hill A, Leavitt BR. Core neuropathological abnormalities in progranulin-deficient mice are penetrant on multiple genetic backgrounds. Neuroscience. 315: 175-195. PMID 26701296 DOI: 10.1016/j.neuroscience.2015.12.006  0.227
2000 Wellington CL, Singaraja R, Ellerby L, Savill J, Roy S, Leavitt B, Cattaneo E, Hackam A, Sharp A, Thornberry N, Nicholson DW, Bredesen DE, Hayden MR. Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells. The Journal of Biological Chemistry. 275: 19831-8. PMID 10770929 DOI: 10.1074/Jbc.M001475200  0.22
2016 Johnson EB, Dürr A, Leavitt B, Roos RA, Langbehn DR, Tabriz SJ, Scahill RI. D9 An evaluation of methods for the volumetric measurement of grey matter in huntington’s disease Journal of Neurology, Neurosurgery, and Psychiatry. 87. DOI: 10.1136/Jnnp-2016-314597.108  0.219
2017 Park KH, Franciosi S, Parant K, Lu G, Leavitt BR. p35 hemizygosity activates Akt but does not improve motor function in the YAC128 mouse model of Huntington's disease. Neuroscience. PMID 28391013 DOI: 10.1016/j.neuroscience.2017.03.051  0.218
2006 Van Raamsdonk JM, Pearson J, Murphy Z, Hayden MR, Leavitt BR. Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease. Bmc Neuroscience. 7: 80. PMID 17147801 DOI: 10.1186/1471-2202-7-80  0.216
2004 Rogers D, Leavitt B. HD aggregates accelerate autophagy Clinical Genetics. 66: 293-294. DOI: 10.1111/j.1399-0004.2004.00347a.x  0.215
2007 Kuhn A, Goldstein DR, Hodges A, Strand AD, Sengstag T, Kooperberg C, Becanovic K, Pouladi MA, Sathasivam K, Cha JH, Hannan AJ, Hayden MR, Leavitt BR, Dunnett SB, Ferrante RJ, et al. Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage. Human Molecular Genetics. 16: 1845-61. PMID 17519223 DOI: 10.1093/Hmg/Ddm133  0.215
2009 van den Bogaard S, Bechtel N, Sturrock A, Jauffret C, Say M, Mills J, Archarya T, Langbehn D, Johnson H, Borowsky B, Durr A, Leavitt B, Roos R, Tabrizi S, Landwehrmeyer B, et al. On Chorea – quantitative and objective analysis – cross-sectional results of the TRACK-HD Study Aktuelle Neurologie. 36. DOI: 10.1055/S-0029-1238519  0.215
2012 Petkau T, Connolly C, Chung R, Fernando S, Leavitt B. P1-177: Progranulin deficiency leads to altered microglial function and neuroinflammation Alzheimer's & Dementia. 8: P169-P170. DOI: 10.1016/j.jalz.2012.05.455  0.214
2023 Van Raamsdonk JM, Al-Shekaili HH, Wagner L, Bredy TW, Chan L, Pearson J, Schwab C, Murphy Z, Devon RS, Lu G, Kobor MS, Hayden MR, Leavitt BR. Huntingtin Decreases Susceptibility to a Spontaneous Seizure Disorder in FVN/B Mice. Aging and Disease. PMID 37199581 DOI: 10.14336/AD.2023.0423  0.213
2022 Thomson SB, Stam A, Brouwers C, Fodale V, Bresciani A, Vermeulen M, Mostafavi S, Petkau TL, Hill A, Yung A, Russell-Schulz B, Kozlowski P, MacKay A, Ma D, Beg MF, ... ... Leavitt BR, et al. AAV5-miHTT-mediated huntingtin lowering improves brain health in a Huntington's disease mouse model. Brain : a Journal of Neurology. PMID 36508327 DOI: 10.1093/brain/awac458  0.211
2003 Zhang Y, Li M, Drozda M, Chen M, Ren S, Mejia Sanchez RO, Leavitt BR, Cattaneo E, Ferrante RJ, Hayden MR, Friedlander RM. Depletion of wild-type huntingtin in mouse models of neurologic diseases. Journal of Neurochemistry. 87: 101-6. PMID 12969257 DOI: 10.1046/J.1471-4159.2003.01980.X  0.21
2015 Bates GP, Dorsey R, Gusella JF, Hayden MR, Kay C, Leavitt BR, Nance M, Ross CA, Scahill RI, Wetzel R, Wild EJ, Tabrizi SJ. Huntington disease. Nature Reviews. Disease Primers. 1: 15005. PMID 27188817 DOI: 10.1038/nrdp.2015.5  0.21
2006 Shehadeh J, Fernandes HB, Zeron Mullins MM, Graham RK, Leavitt BR, Hayden MR, Raymond LA. Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease. Neurobiology of Disease. 21: 392-403. PMID 16165367 DOI: 10.1016/J.Nbd.2005.08.001  0.209
2020 Laroche M, Lessard-Beaudoin M, Garcia-Miralles M, Kreidy C, Peachey E, Leavitt BR, Pouladi MA, Graham RK. Early deficits in olfaction are associated with structural and molecular alterations in the olfactory system of a Huntington disease mouse model. Human Molecular Genetics. PMID 32436947 DOI: 10.1093/Hmg/Ddaa099  0.208
2019 Hooper G, Palermo G, Hlavac F, Finnegan C, Frick E, Boak L, Doody R, Schobel S, Leavitt B. The Roche HD natural history study – An external comparator by design Journal of the Neurological Sciences. 405: 312. DOI: 10.1016/J.Jns.2019.10.1409  0.208
1989 Maysinger D, Zorc B, Leavitt BR, Butula I, Chubb FL, Cuello AC. Structural analogs of hemicholinium: effects on cholinergic and GABAergic markers in the CNS. Neurochemistry International. 15: 531-9. PMID 20504529  0.207
2015 Sturrock A, Laule C, Wyper K, Milner RA, Decolongon J, Dar Santos R, Coleman AJ, Carter K, Creighton S, Bechtel N, Bohlen S, Reilmann R, Johnson HJ, Hayden MR, Tabrizi SJ, ... ... Leavitt BR, et al. A longitudinal study of magnetic resonance spectroscopy Huntington's disease biomarkers. Movement Disorders : Official Journal of the Movement Disorder Society. 30: 393-401. PMID 25690257 DOI: 10.1002/Mds.26118  0.206
2024 Caron NS, Aly AE, Black HF, Martin DDO, Schmidt ME, Ko S, Anderson C, Harvey EM, Casal LL, Anderson LM, Rahavi SMR, Reid GSD, Oda MN, Stanimirovic D, Abulrob A, ... ... Leavitt BR, et al. Systemic delivery of mutant huntingtin lowering antisense oligonucleotides to the brain using apolipoprotein A-I nanodisks for Huntington disease. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 38215984 DOI: 10.1016/j.jconrel.2024.01.011  0.205
2006 Mazarei G, Wagner LA, Leavitt BR. Pathogenesis in SCA8 is a two-way street Clinical Genetics. 70: 382-383. DOI: 10.1111/j.1399-0004.2006.0699_1.x  0.204
2006 Guidetti P, Bates GP, Graham RK, Hayden MR, Leavitt BR, MacDonald ME, Slow EJ, Wheeler VC, Woodman B, Schwarcz R. Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice. Neurobiology of Disease. 23: 190-7. PMID 16697652 DOI: 10.1016/J.Nbd.2006.02.011  0.203
2002 Gervais FG, Singaraja R, Xanthoudakis S, Gutekunst CA, Leavitt BR, Metzler M, Hackam AS, Tam J, Vaillancourt JP, Houtzager V, Rasper DM, Roy S, Hayden MR, Nicholson DW. Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi. Nature Cell Biology. 4: 95-105. PMID 11788820 DOI: 10.1038/Ncb735  0.201
2006 Neal SJ, Leavitt BR. Bad neighbors cause dementia; a second 17q21-linked gene responsible for frontotemporal dementia Clinical Genetics. 70: 385-387. DOI: 10.1111/j.1399-0004.2006.00699_3.x  0.2
2011 Sivananthan SN, Leavitt BR. Cystamine and ethyl-eicosapentaenoic acid treatment fail to prevent malonate-induced striatal toxicity in mice. Neurobiology of Aging. 32: 2326.e1-4. PMID 21741126 DOI: 10.1016/j.neurobiolaging.2011.05.020  0.2
2020 Leavitt BR, Kordasiewicz HB, Schobel SA. Huntingtin-Lowering Therapies for Huntington Disease: A Review of the Evidence of Potential Benefits and Risks. Jama Neurology. PMID 32202594 DOI: 10.1001/Jamaneurol.2020.0299  0.2
2005 Yamashita DT, Leavitt BR. Silent, but deadly: Epigenetic control of ID4 in leukemia Clinical Genetics. 68: 196. DOI: 10.1111/j.1399-0004.2005.00494c.x  0.197
2013 Park KH, Franciosi S, Leavitt BR. Postnatal muscle modification by myogenic factors modulates neuropathology and survival in an ALS mouse model. Nature Communications. 4: 2906. PMID 24346342 DOI: 10.1038/ncomms3906  0.196
1992 Maysinger D, Leavitt BR, Zorc B, Butula I, Fernandes LG, Ribeiro-da-Silva A. Inhibition of high affinity choline uptake in the rat brain by neurotoxins: effect of monosialoganglioside GM1. Neurochemistry International. 20: 289-97. PMID 1304326 DOI: 10.1016/0197-0186(92)90043-Q  0.196
2014 Ehrnhoefer DE, Skotte NH, Ladha S, Nguyen YT, Qiu X, Deng Y, Huynh KT, Engemann S, Nielsen SM, Becanovic K, Leavitt BR, Hasholt L, Hayden MR. p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin. Human Molecular Genetics. 23: 717-29. PMID 24070868 DOI: 10.1093/Hmg/Ddt458  0.196
2018 Gregory S, Long JD, Klöppel S, Razi A, Scheller E, Minkova L, Johnson EB, Durr A, Roos RAC, Leavitt BR, Mills JA, Stout JC, Scahill RI, Tabrizi SJ, Rees G, et al. Testing a longitudinal compensation model in premanifest Huntington's disease. Brain : a Journal of Neurology. PMID 29788038 DOI: 10.1093/Brain/Awy122  0.193
2003 Leavitt B. Something lost in the translation: ‘premutations’ in the FMR1 gene cause Fragile X tremor/ataxia syndrome (FXTAS) Clinical Genetics. 64: 106-108. DOI: 10.1034/J.1399-0004.2003.T01-1-00130.X  0.191
2006 Becanovic K, Leavitt BR. Age-related dysfunction of the cellular powerplants Clinical Genetics. 70: 383-385. DOI: 10.1111/j.1399-0004.2006.0699_2.x  0.191
2005 Van Raamsdonk JM, Pearson J, Rogers DA, Bissada N, Vogl AW, Hayden MR, Leavitt BR. Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease. Human Molecular Genetics. 14: 1379-92. PMID 15829505 DOI: 10.1093/Hmg/Ddi147  0.19
2016 Disatnik MH, Joshi AU, Saw NL, Shamloo M, Leavitt BR, Qi X, Mochly-Rosen D. Potential biomarkers to follow the progression and treatment response of Huntington's disease. The Journal of Experimental Medicine. PMID 27821553 DOI: 10.1084/Jem.20160776  0.188
2011 Tabrizi SJ, Scahill RI, Durr A, Roos RA, Leavitt BR, Jones R, Landwehrmeyer GB, Fox NC, Johnson H, Hicks SL, Kennard C, Craufurd D, Frost C, Langbehn DR, Reilmann R, et al. Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis. The Lancet. Neurology. 10: 31-42. PMID 21130037 DOI: 10.1016/S1474-4422(10)70276-3  0.188
2013 Mazarei G, Budac DP, Lu G, Lee H, Möller T, Leavitt BR. The absence of indoleamine 2,3-dioxygenase expression protects against NMDA receptor-mediated excitotoxicity in mouse brain. Experimental Neurology. 249: 144-8. PMID 23994717 DOI: 10.1016/j.expneurol.2013.08.007  0.187
2015 Jan A, Karasinska JM, Kang MH, de Haan W, Ruddle P, Kaur A, Connolly C, Leavitt BR, Sorensen PH, Hayden MR. Direct intracerebral delivery of a miR-33 antisense oligonucelotide into mouse brain increases brain ABCA1 expression. Neuroscience Letters. 598: 66-72. PMID 25957561 DOI: 10.1016/J.Neulet.2015.05.007  0.187
2018 Thomson SB, Leavitt BR. Transcriptional Regulation of the Huntingtin Gene. Journal of Huntington's Disease. PMID 30452421 DOI: 10.3233/JHD-180331  0.186
2018 Minkova L, Gregory S, Scahill RI, Abdulkadir A, Kaller CP, Peter J, Long JD, Stout JC, Reilmann R, Roos RA, Durr A, Leavitt BR, Tabrizi SJ, Klöppel S. Cross-sectional and longitudinal voxel-based grey matter asymmetries in Huntington's disease. Neuroimage. Clinical. 17: 312-324. PMID 29527479 DOI: 10.1016/J.Nicl.2017.10.023  0.186
2016 Labuschagne I, Cassidy AM, Scahill RI, Johnson EB, Rees E, O'Regan A, Queller S, Frost C, Leavitt BR, Dürr A, Roos R, Owen G, Borowsky B, Tabrizi SJ, Stout JC, et al. Visuospatial Processing Deficits Linked to Posterior Brain Regions in Premanifest and Early Stage Huntington's Disease. Journal of the International Neuropsychological Society : Jins. 1-14. PMID 27211109 DOI: 10.1017/S1355617716000321  0.185
2007 Orban P, Devon RS, Hayden MR, Leavitt BR. Chapter 15 Juvenile amyotrophic lateral sclerosis. Handbook of Clinical Neurology. 82: 301-12. PMID 18808900 DOI: 10.1016/S0072-9752(07)80018-2  0.185
2010 Sturrock A, Laule C, Decolongon J, Dar Santos R, Coleman AJ, Creighton S, Bechtel N, Reilmann R, Hayden MR, Tabrizi SJ, Mackay AL, Leavitt BR. Magnetic resonance spectroscopy biomarkers in premanifest and early Huntington disease. Neurology. 75: 1702-10. PMID 21060093 DOI: 10.1212/Wnl.0B013E3181Fc27E4  0.184
2017 McColgan P, Gregory S, Seunarine KK, Razi A, Papoutsi M, Johnson E, Durr A, Roos RAC, Leavitt BR, Holmans P, Scahill RI, Clark CA, Rees G, Tabrizi SJ. Brain Regions Showing White Matter Loss in Huntington's Disease Are Enriched for Synaptic and Metabolic Genes. Biological Psychiatry. PMID 29174593 DOI: 10.1016/J.Biopsych.2017.10.019  0.183
2023 McColgan P, Thobhani A, Boak L, Schobel SA, Nicotra A, Palermo G, Trundell D, Zhou J, Schlegel V, Sanwald Ducray P, Hawellek DJ, Dorn J, Simillion C, Lindemann M, Wheelock V, ... ... Leavitt BR, et al. Tominersen in Adults with Manifest Huntington's Disease. The New England Journal of Medicine. 389: 2203-2205. PMID 38055260 DOI: 10.1056/NEJMc2300400  0.183
2009 Tabrizi SJ, Langbehn DR, Leavitt BR, Roos RA, Durr A, Craufurd D, Kennard C, Hicks SL, Fox NC, Scahill RI, Borowsky B, Tobin AJ, Rosas HD, Johnson H, Reilmann R, et al. Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data. The Lancet. Neurology. 8: 791-801. PMID 19646924 DOI: 10.1016/S1474-4422(09)70170-X  0.182
2010 Lahiri N, Tabrizi SJ, Kennard C, Durr A, Leavitt BR, Fox N, Roos RA. POMD07 Quantitative assessment of biological and clinical manifestations of Huntington's disease before and after diagnosis--the TRACK-HD study Journal of Neurology, Neurosurgery & Psychiatry. 81: e59-e59. DOI: 10.1136/Jnnp.2010.226340.167  0.181
2021 Petkau TL, Life B, Lu G, Yang J, Fornes O, Wasserman W, Simpson EM, Leavitt BR. Human progranulin-expressing mice as a novel tool for the development of progranulin-modulating therapeutics. Neurobiology of Disease. 105314. PMID 33636385 DOI: 10.1016/j.nbd.2021.105314  0.181
2013 Mazarei G, Budac DP, Lu G, Adomat H, Tomlinson Guns ES, Möller T, Leavitt BR. Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease. Journal of Neurochemistry. 127: 852-67. PMID 23786539 DOI: 10.1111/jnc.12350  0.181
2012 Petkau TL, Neal SJ, Milnerwood A, Mew A, Hill AM, Orban P, Gregg J, Lu G, Feldman HH, Mackenzie IR, Raymond LA, Leavitt BR. Synaptic dysfunction in progranulin-deficient mice. Neurobiology of Disease. 45: 711-22. PMID 22062772 DOI: 10.1016/J.Nbd.2011.10.016  0.181
2010 Becanovic K, Pouladi MA, Lim RS, Kuhn A, Pavlidis P, Luthi-Carter R, Hayden MR, Leavitt BR. Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis. Human Molecular Genetics. 19: 1438-52. PMID 20089533 DOI: 10.1093/Hmg/Ddq018  0.177
2023 Adair BA, Korecki AJ, Djaksigulova D, Wagner PK, Chiu NY, Lam SL, Lengyell TC, Leavitt BR, Simpson EM. ABE8e Corrects Pax6-Aniridic Variant in Humanized Mouse ESCs and via LNPs in Ex Vivo Cortical Neurons. Ophthalmology and Therapy. PMID 37210469 DOI: 10.1007/s40123-023-00729-6  0.177
2020 Mitchell CT, Krier I, Arjomand J, Borowsky B, Tabrizi SJ, Leavitt BR, Luthi-Carter R. Longitudinal expression changes are weak correlates of disease progression in Huntington's disease. Brain Communications. 2: fcaa172. PMID 33305259 DOI: 10.1093/braincomms/fcaa172  0.176
2001 Leavitt BR, Guttman JA, Hodgson JG, Kimel GH, Singaraja R, Vogl AW, Hayden MR. Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo. American Journal of Human Genetics. 68: 313-24. PMID 11133364 DOI: 10.1086/318207  0.176
2009 Fang Q, Strand A, Law W, Faca VM, Fitzgibbon MP, Hamel N, Houle B, Liu X, May DH, Poschmann G, Roy L, Stühler K, Ying W, Zhang J, Zheng Z, ... ... Leavitt BR, et al. Brain-specific proteins decline in the cerebrospinal fluid of humans with Huntington disease. Molecular & Cellular Proteomics : McP. 8: 451-66. PMID 18984577 DOI: 10.1074/Mcp.M800231-Mcp200  0.175
2017 Quinti L, Dayalan Naidu S, Träger U, Chen X, Kegel-Gleason K, Llères D, Connolly C, Chopra V, Low C, Moniot S, Sapp E, Tousley AR, Vodicka P, Van Kanegan MJ, Kaltenbach LS, ... ... Leavitt BR, et al. KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients. Proceedings of the National Academy of Sciences of the United States of America. PMID 28533375 DOI: 10.1073/Pnas.1614943114  0.175
2023 Life B, Bettio LEB, Gantois I, Christie BR, Leavitt BR. Progranulin is an FMRP target that influences macroorchidism but not behaviour in a mouse model of Fragile X Syndrome. Current Research in Neurobiology. 5: 100094. PMID 37416094 DOI: 10.1016/j.crneur.2023.100094  0.174
2015 Mazarei G, Leavitt BR. Indoleamine 2,3 Dioxygenase as a Potential Therapeutic Target in Huntington's Disease. Journal of Huntington's Disease. 4: 109-18. PMID 26397892 DOI: 10.3233/JHD-159003  0.173
2005 Pearson J, Leavitt BR. TB or not TB? Ipr1 answers the question Clinical Genetics. 68: 193-198. DOI: 10.1111/j.1399-0004.2005.0494a.x  0.171
2002 Chan EY, Luthi-Carter R, Strand A, Solano SM, Hanson SA, DeJohn MM, Kooperberg C, Chase KO, DiFiglia M, Young AB, Leavitt BR, Cha JH, Aronin N, Hayden MR, Olson JM. Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease. Human Molecular Genetics. 11: 1939-51. PMID 12165556 DOI: 10.1093/Hmg/11.17.1939  0.171
2017 McColgan P, Gregory S, Razi A, Seunarine KK, Gargouri F, Durr A, Roos RA, Leavitt BR, Scahill RI, Clark CA, Tabrizi SJ, Rees G, Coleman A, Decolongon J, et al. White matter predicts functional connectivity in premanifest Huntington's disease. Annals of Clinical and Translational Neurology. 4: 106-118. PMID 28168210 DOI: 10.1002/Acn3.384  0.17
2004 Zeron MM, Fernandes HB, Krebs C, Shehadeh J, Wellington CL, Leavitt BR, Baimbridge KG, Hayden MR, Raymond LA. Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease. Molecular and Cellular Neurosciences. 25: 469-79. PMID 15033175 DOI: 10.1016/J.Mcn.2003.11.014  0.17
2014 Petkau TL, Leavitt BR. Progranulin in neurodegenerative disease. Trends in Neurosciences. 37: 388-98. PMID 24800652 DOI: 10.1016/j.tins.2014.04.003  0.169
2017 Byrne LM, Rodrigues FB, Blennow K, Durr A, Leavitt BR, Roos RAC, Scahill RI, Tabrizi SJ, Zetterberg H, Langbehn D, Wild EJ. Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington's disease: a retrospective cohort analysis. The Lancet. Neurology. PMID 28601473 DOI: 10.1016/S1474-4422(17)30124-2  0.167
2015 Minkova L, Scheller E, Peter J, Abdulkadir A, Kaller CP, Roos RA, Durr A, Leavitt BR, Tabrizi SJ, Klöppel S. Detection of Motor Changes in Huntington's Disease Using Dynamic Causal Modeling. Frontiers in Human Neuroscience. 9: 634. PMID 26635585 DOI: 10.3389/Fnhum.2015.00634  0.166
2015 Johnson EB, Rees EM, Labuschagne I, Durr A, Leavitt BR, Roos RA, Reilmann R, Johnson H, Hobbs NZ, Langbehn DR, Stout JC, Tabrizi SJ, Scahill RI. The impact of occipital lobe cortical thickness on cognitive task performance: An investigation in Huntington's Disease. Neuropsychologia. PMID 26519555 DOI: 10.1016/J.Neuropsychologia.2015.10.033  0.165
2015 De Souza RA, Leavitt BR. Neurobiology of Huntington's Disease. Current Topics in Behavioral Neurosciences. 22: 81-100. PMID 25205327 DOI: 10.1007/7854_2014_353  0.165
2002 Ariano MA, Aronin N, Difiglia M, Tagle DA, Sibley DR, Leavitt BR, Hayden MR, Levine MS. Striatal neurochemical changes in transgenic models of Huntington's disease. Journal of Neuroscience Research. 68: 716-29. PMID 12111832 DOI: 10.1002/Jnr.10272  0.165
2013 Scahill RI, Hobbs NZ, Say MJ, Bechtel N, Henley SM, Hyare H, Langbehn DR, Jones R, Leavitt BR, Roos RA, Durr A, Johnson H, Lehéricy S, Craufurd D, Kennard C, et al. Clinical impairment in premanifest and early Huntington's disease is associated with regionally specific atrophy. Human Brain Mapping. 34: 519-29. PMID 22102212 DOI: 10.1002/Hbm.21449  0.162
1999 Leavitt BR, Wellington CL, Hayden MR. Recent insights into the molecular pathogenesis of Huntington disease. Seminars in Neurology. 19: 385-95. PMID 10716661 DOI: 10.1055/S-2008-1040853  0.161
2005 Pinto JT, Van Raamsdonk JM, Leavitt BR, Hayden MR, Jeitner TM, Thaler HT, Krasnikov BF, Cooper AJ. Treatment of YAC128 mice and their wild-type littermates with cystamine does not lead to its accumulation in plasma or brain: implications for the treatment of Huntington disease. Journal of Neurochemistry. 94: 1087-101. PMID 15992377 DOI: 10.1111/J.1471-4159.2005.03255.X  0.16
2017 Kay C, Hayden MR, Leavitt BR. Epidemiology of Huntington disease. Handbook of Clinical Neurology. 144: 31-46. PMID 28947124 DOI: 10.1016/B978-0-12-801893-4.00003-1  0.16
2018 Kosior N, Leavitt BR. Murine Models of Huntington's Disease for Evaluating Therapeutics. Methods in Molecular Biology (Clifton, N.J.). 1780: 179-207. PMID 29856020 DOI: 10.1007/978-1-4939-7825-0_10  0.159
2015 Southwell AL, Smith SE, Davis TR, Caron NS, Villanueva EB, Xie Y, Collins JA, Li Ye M, Sturrock A, Leavitt BR, Schrum AG, Hayden MR. Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression. Scientific Reports. 5: 12166. PMID 26174131 DOI: 10.1038/Srep12166  0.159
2021 Morozko EL, Smith-Geater C, Monteys AM, Pradhan S, Lim RG, Langfelder P, Kachemov M, Hill A, Stocksdale JT, Cullis PR, Wu J, Ochaba J, Miramontes R, Chakraborty A, Hazra TK, ... ... Leavitt BR, et al. PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington's disease. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33468657 DOI: 10.1073/pnas.2021836118  0.158
2014 Ross CA, Aylward EH, Wild EJ, Langbehn DR, Long JD, Warner JH, Scahill RI, Leavitt BR, Stout JC, Paulsen JS, Reilmann R, Unschuld PG, Wexler A, Margolis RL, Tabrizi SJ. Huntington disease: natural history, biomarkers and prospects for therapeutics. Nature Reviews. Neurology. 10: 204-16. PMID 24614516 DOI: 10.1038/Nrneurol.2014.24  0.158
2014 Muller M, Leavitt BR. Iron dysregulation in Huntington's disease. Journal of Neurochemistry. 130: 328-50. PMID 24717009 DOI: 10.1111/jnc.12739  0.157
2002 Panov AV, Gutekunst CA, Leavitt BR, Hayden MR, Burke JR, Strittmatter WJ, Greenamyre JT. Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines. Nature Neuroscience. 5: 731-6. PMID 12089530 DOI: 10.1038/Nn884  0.157
2010 Bechtel N, Scahill RI, Rosas HD, Acharya T, van den Bogaard SJ, Jauffret C, Say MJ, Sturrock A, Johnson H, Onorato CE, Salat DH, Durr A, Leavitt BR, Roos RA, Landwehrmeyer GB, et al. Tapping linked to function and structure in premanifest and symptomatic Huntington disease. Neurology. 75: 2150-60. PMID 21068430 DOI: 10.1212/Wnl.0B013E3182020123  0.156
2014 Reilmann R, Leavitt BR, Ross CA. Diagnostic criteria for Huntington's disease based on natural history. Movement Disorders : Official Journal of the Movement Disorder Society. 29: 1335-41. PMID 25164527 DOI: 10.1002/Mds.26011  0.156
2016 De Souza RA, Islam SA, McEwen LM, Mathelier A, Hill A, Mah SM, Wasserman WW, Kobor MS, Leavitt BR. DNA Methylation Profiling in Human Huntington's Disease Brain. Human Molecular Genetics. PMID 26953320 DOI: 10.1093/hmg/ddw076  0.155
2014 Träger U, Andre R, Magnusson-Lind A, Miller JR, Connolly C, Weiss A, Grueninger S, Silajdži? E, Smith DL, Leavitt BR, Bates GP, Björkqvist M, Tabrizi SJ. Characterisation of immune cell function in fragment and full-length Huntington's disease mouse models. Neurobiology of Disease. 73: 388-398. PMID 25447230 DOI: 10.1016/j.nbd.2014.10.012  0.154
2016 Orth M, Gregory S, Scahill RI, Mayer IS, Minkova L, Klöppel S, Seunarine KK, Boyd L, Borowsky B, Reilmann R, Bernhard Landwehrmeyer G, Leavitt BR, Roos RA, Durr A, Rees G, et al. Natural variation in sensory-motor white matter organization influences manifestations of Huntington's disease. Human Brain Mapping. PMID 27477323 DOI: 10.1002/Hbm.23332  0.154
2011 Hobbs NZ, Pedrick AV, Say MJ, Frost C, Dar Santos R, Coleman A, Sturrock A, Craufurd D, Stout JC, Leavitt BR, Barnes J, Tabrizi SJ, Scahill RI. The structural involvement of the cingulate cortex in premanifest and early Huntington's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 26: 1684-90. PMID 21557312 DOI: 10.1002/mds.23747  0.153
2017 McColgan P, Seunarine KK, Gregory S, Razi A, Papoutsi M, Long JD, Mills JA, Johnson E, Durr A, Roos RAC, Leavitt BR, Stout JC, Scahill RI, Clark CA, Rees G, et al. Topological length of white matter connections predicts their rate of atrophy in premanifest Huntington's disease. Jci Insight. 2. PMID 28422761 DOI: 10.1172/Jci.Insight.92641  0.152
2023 Estevez-Fraga C, Elmalem MS, Papoutsi M, Durr A, Rees EM, Hobbs NZ, Roos RAC, Landwehrmeyer B, Leavitt BR, Langbehn DR, Scahill RI, Rees G, Tabrizi SJ, Gregory S. Progressive alterations in white matter microstructure across the timecourse of Huntington's disease. Brain and Behavior. e2940. PMID 36917716 DOI: 10.1002/brb3.2940  0.152
2012 Tabrizi SJ, Reilmann R, Roos RA, Durr A, Leavitt B, Owen G, Jones R, Johnson H, Craufurd D, Hicks SL, Kennard C, Landwehrmeyer B, Stout JC, Borowsky B, Scahill RI, et al. Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data. The Lancet. Neurology. 11: 42-53. PMID 22137354 DOI: 10.1016/S1474-4422(11)70263-0  0.151
2024 Reilmann R, Anderson KE, Feigin A, Tabrizi SJ, Leavitt BR, Stout JC, Piccini P, Schubert R, Loupe P, Wickenberg A, Borowsky B, Rynkowski G, Volkinshtein R, Li T, Savola JM, et al. Safety and efficacy of laquinimod for Huntington's disease (LEGATO-HD): a multicentre, randomised, double-blind, placebo-controlled, phase 2 study. The Lancet. Neurology. PMID 38280392 DOI: 10.1016/S1474-4422(23)00454-4  0.151
2019 Tabrizi SJ, Ghosh R, Leavitt BR. Huntingtin Lowering Strategies for Disease Modification in Huntington's Disease. Neuron. 101: 801-819. PMID 30844400 DOI: 10.1016/j.neuron.2019.01.039  0.15
2012 Long JD, Matson WR, Juhl AR, Leavitt BR, Paulsen JS. 8OHdG as a marker for Huntington disease progression. Neurobiology of Disease. 46: 625-34. PMID 22414782 DOI: 10.1016/j.nbd.2012.02.012  0.148
2013 Tabrizi SJ, Scahill RI, Owen G, Durr A, Leavitt BR, Roos RA, Borowsky B, Landwehrmeyer B, Frost C, Johnson H, Craufurd D, Reilmann R, Stout JC, Langbehn DR. Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data. The Lancet. Neurology. 12: 637-49. PMID 23664844 DOI: 10.1016/S1474-4422(13)70088-7  0.148
2022 Tabrizi SJ, Estevez-Fraga C, van Roon-Mom WMC, Flower MD, Scahill RI, Wild EJ, Muñoz-Sanjuan I, Sampaio C, Rosser AE, Leavitt BR. Potential disease-modifying therapies for Huntington's disease: lessons learned and future opportunities. The Lancet. Neurology. 21: 645-658. PMID 35716694 DOI: 10.1016/S1474-4422(22)00121-1  0.145
2019 Tabrizi SJ, Leavitt BR, Landwehrmeyer GB, Wild EJ, Saft C, Barker RA, Blair NF, Craufurd D, Priller J, Rickards H, Rosser A, Kordasiewicz HB, Czech C, Swayze EE, Norris DA, et al. Targeting Huntingtin Expression in Patients with Huntington's Disease. The New England Journal of Medicine. PMID 31059641 DOI: 10.1056/Nejmoa1900907  0.145
2021 Bečanović K, Muhammad A, Gadawska I, Sachdeva S, Walker D, Lazarowski ER, Franciosi S, Park KHJ, Côté HCF, Leavitt BR. Age-related mitochondrial alterations in brain and skeletal muscle of the YAC128 model of Huntington disease. Npj Aging and Mechanisms of Disease. 7: 26. PMID 34650085 DOI: 10.1038/s41514-021-00079-2  0.145
2023 Life B, Petkau TL, Cruz GNF, Navarro-Delgado EI, Shen N, Korthauer K, Leavitt BR. FTD-associated behavioural and transcriptomic abnormalities in 'humanized' progranulin-deficient mice: A novel model for progranulin-associated FTD. Neurobiology of Disease. 182: 106138. PMID 37105261 DOI: 10.1016/j.nbd.2023.106138  0.144
2022 Mirjalili Mohanna SZ, Djaksigulova D, Hill AM, Wagner PK, Simpson EM, Leavitt BR. LNP-mediated delivery of CRISPR RNP for wide-spread in vivo genome editing in mouse cornea. Journal of Controlled Release : Official Journal of the Controlled Release Society. 350: 401-413. PMID 36029893 DOI: 10.1016/j.jconrel.2022.08.042  0.144
2020 Gregory S, Lohse KR, Johnson EB, Leavitt BR, Durr A, Roos RAC, Rees G, Tabrizi SJ, Scahill RI, Orth M. Longitudinal Structural MRI in Neurologically Healthy Adults. Journal of Magnetic Resonance Imaging : Jmri. PMID 32469154 DOI: 10.1002/Jmri.27203  0.142
2016 Rodrigues FB, Byrne L, McColgan P, Robertson N, Tabrizi SJ, Leavitt BR, Zetterberg H, Wild EJ. Cerebrospinal fluid total tau concentration predicts clinical phenotype in Huntington's disease. Journal of Neurochemistry. PMID 27344050 DOI: 10.1111/jnc.13719  0.142
2013 Crawford HE, Hobbs NZ, Keogh R, Langbehn DR, Frost C, Johnson H, Landwehrmeyer B, Reilmann R, Craufurd D, Stout JC, Durr A, Leavitt BR, Roos RA, Tabrizi SJ, Scahill RI, et al. Corpus callosal atrophy in premanifest and early Huntington's disease. Journal of Huntington's Disease. 2: 517-26. PMID 25062736 DOI: 10.3233/Jhd-130077  0.142
2012 Franciosi S, Ryu JK, Shim Y, Hill A, Connolly C, Hayden MR, McLarnon JG, Leavitt BR. Age-dependent neurovascular abnormalities and altered microglial morphology in the YAC128 mouse model of Huntington disease. Neurobiology of Disease. 45: 438-49. PMID 21946335 DOI: 10.1016/J.Nbd.2011.09.003  0.14
2007 Björkqvist M, Leavitt BR, Nielsen JE, Landwehrmeyer B, Ecker D, Mulder H, Brundin P, Petersén A. Cocaine- and amphetamine-regulated transcript is increased in Huntington disease. Movement Disorders : Official Journal of the Movement Disorder Society. 22: 1952-4. PMID 17722045 DOI: 10.1002/Mds.21447  0.139
2011 Weir DW, Sturrock A, Leavitt BR. Development of biomarkers for Huntington's disease. The Lancet. Neurology. 10: 573-90. PMID 21601164 DOI: 10.1016/S1474-4422(11)70070-9  0.139
2015 Klöppel S, Gregory S, Scheller E, Minkova L, Razi A, Durr A, Roos RAC, Leavitt BR, Papoutsi M, Landwehrmeyer GB, Reilmann R, Borowsky B, Johnson H, Mills JA, Owen G, et al. Compensation in Preclinical Huntington's Disease: Evidence From the Track-On HD Study Ebiomedicine. DOI: 10.1016/j.ebiom.2015.08.002  0.138
2013 Franciosi S, Shim Y, Lau M, Hayden MR, Leavitt BR. A systematic review and meta-analysis of clinical variables used in Huntington disease research. Movement Disorders : Official Journal of the Movement Disorder Society. 28: 1987-94. PMID 24142393 DOI: 10.1002/Mds.25663  0.137
2013 Boxer AL, Gold M, Huey E, Hu WT, Rosen H, Kramer J, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, et al. The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier). Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 189-98. PMID 23062850 DOI: 10.1016/J.Jalz.2012.03.003  0.136
2018 Johnson EB, Byrne LM, Gregory S, Rodrigues FB, Blennow K, Durr A, Leavitt BR, Roos RA, Zetterberg H, Tabrizi SJ, Scahill RI, Wild EJ. Neurofilament light protein in blood predicts regional atrophy in Huntington disease. Neurology. PMID 29367444 DOI: 10.1212/Wnl.0000000000005005  0.136
2008 Björkqvist M, Wild EJ, Thiele J, Silvestroni A, Andre R, Lahiri N, Raibon E, Lee RV, Benn CL, Soulet D, Magnusson A, Woodman B, Landles C, Pouladi MA, Hayden MR, ... ... Leavitt BR, et al. A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease. The Journal of Experimental Medicine. 205: 1869-77. PMID 18625748 DOI: 10.1084/Jem.20080178  0.136
2022 Caron NS, Haqqani AS, Sandhu A, Aly AE, Findlay Black H, Bone JN, McBride JL, Abulrob A, Stanimirovic D, Leavitt BR, Hayden MR. Cerebrospinal fluid biomarkers for assessing Huntington disease onset and severity. Brain Communications. 4: fcac309. PMID 36523269 DOI: 10.1093/braincomms/fcac309  0.135
2005 Van Raamsdonk JM, Hayden MR, Leavitt BR. Experimental models of Huntington's disease Drug Discovery Today: Disease Models. 2: 291-297. DOI: 10.1016/J.Ddmod.2005.11.010  0.135
2013 Read J, Jones R, Owen G, Leavitt BR, Coleman A, Roos RA, Dumas EM, Durr A, Justo D, Say M, Stout JC, Tabrizi SJ, Craufurd D. Quality of life in Huntington's disease: a comparative study investigating the impact for those with pre-manifest and early manifest disease, and their partners. Journal of Huntington's Disease. 2: 159-75. PMID 25063513 DOI: 10.3233/JHD-130051  0.135
2022 Rodrigues FB, Owen G, Sathe S, Pak E, Kaur D, Ehrhardt AG, Lifer S, Townhill J, Schubert K, Leavitt BR, Guttman M, Bang J, Lewerenz J, Levey J, Sampaio C, et al. Safety and Feasibility of Research Lumbar Puncture in Huntington's Disease: The HDClarity Cohort and Bioresource. Journal of Huntington's Disease. 11: 59-69. PMID 35253773 DOI: 10.3233/JHD-210508  0.133
2021 Abreu D, Ware J, Georgiou-Karistianis N, Leavitt BR, Fitzer-Attas CJ, Lobo R, Fernandes AR, Handley O, Anderson KE, Stout JC, Sampaio C. Utility of Huntington's Disease Assessments by Disease Stage: Floor/Ceiling Effects. Frontiers in Neurology. 12: 595679. PMID 34335433 DOI: 10.3389/fneur.2021.595679  0.132
2010 Sturrock A, Leavitt BR. The clinical and genetic features of Huntington disease. Journal of Geriatric Psychiatry and Neurology. 23: 243-59. PMID 20923757 DOI: 10.1177/0891988710383573  0.132
2015 Jan A, Karasinska JM, Kang MH, Haan Wd, Ruddle P, Kaur A, Connolly C, Leavitt BR, Sorensen PH, Hayden MR. Corrigendum to "Direct intracerebral delivery of a miR-33 antisense oligonucleotide into mouse brain increases brain ABCA1 expression'' [Neuroscience Letters 598 (2015) 66-72] Neuroscience Letters. 602: 172. DOI: 10.1016/J.Neulet.2015.06.047  0.131
2010 Pouladi MA, Xie Y, Skotte NH, Ehrnhoefer DE, Graham RK, Kim JE, Bissada N, Yang XW, Paganetti P, Friedlander RM, Leavitt BR, Hayden MR. Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression. Human Molecular Genetics. 19: 1528-38. PMID 20097678 DOI: 10.1093/Hmg/Ddq026  0.131
2017 Moss DJH, Pardiñas AF, Langbehn D, Lo K, Leavitt BR, Roos R, Durr A, Mead S, Holmans P, Jones L, Tabrizi SJ. Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study. The Lancet. Neurology. PMID 28642124 DOI: 10.1016/S1474-4422(17)30161-8  0.13
2019 Langbehn DR, Stout JC, Gregory S, Mills JA, Durr A, Leavitt BR, Roos RAC, Long JD, Owen G, Johnson HJ, Borowsky B, Craufurd D, Reilmann R, Landwehrmeyer GB, Scahill RI, et al. Association of CAG Repeats With Long-term Progression in Huntington Disease. Jama Neurology. PMID 31403680 DOI: 10.1001/Jamaneurol.2019.2368  0.129
2015 Bečanović K, Nørremølle A, Neal SJ, Kay C, Collins JA, Arenillas D, Lilja T, Gaudenzi G, Manoharan S, Doty CN, Beck J, Lahiri N, Portales-Casamar E, Warby SC, Connolly C, ... ... Leavitt BR, et al. A SNP in the HTT promoter alters NF-κB binding and is a bidirectional genetic modifier of Huntington disease. Nature Neuroscience. 18: 807-16. PMID 25938884 DOI: 10.1038/Nn.4014  0.127
2024 Coleman A, Langan MT, Verma G, Knights H, Sturrock A, Leavitt BR, Tabrizi SJ, Scahill RI, Hobbs NZ. Assessment of Perivascular Space Morphometry Across the White Matter in Huntington's Disease Using MRI. Journal of Huntington's Disease. 13: 91-101. PMID 38517798 DOI: 10.3233/JHD-231508  0.127
2012 Connolly C, Hill A, Leavitt BR. Microglia in huntington disease Microglia: Biology, Functions and Roles in Disease. 253-271.  0.127
2014 Kostro D, Abdulkadir A, Durr A, Roos R, Leavitt BR, Johnson H, Cash D, Tabrizi SJ, Scahill RI, Ronneberger O, Klöppel S. Correction of inter-scanner and within-subject variance in structural MRI based automated diagnosing. Neuroimage. 98: 405-15. PMID 24791746 DOI: 10.1016/J.Neuroimage.2014.04.057  0.126
2017 Johnson EB, Gregory S, Johnson HJ, Durr A, Leavitt BR, Roos RA, Rees G, Tabrizi SJ, Scahill RI. Recommendations for the Use of Automated Gray Matter Segmentation Tools: Evidence from Huntington's Disease. Frontiers in Neurology. 8: 519. PMID 29066997 DOI: 10.3389/Fneur.2017.00519  0.126
2022 Bénard A, Chouinard S, Leavitt BR, Budd N, Wu JW, Schoffer K. Canadian healthcare capacity gaps for disease-modifying treatment in Huntington's disease: a survey of current practice and modelling of future needs. Bmj Open. 12: e062740. PMID 35649593 DOI: 10.1136/bmjopen-2022-062740  0.125
2005 Van Raamsdonk JM, Pearson J, Slow EJ, Hossain SM, Leavitt BR, Hayden MR. Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 4169-80. PMID 15843620 DOI: 10.1523/Jneurosci.0590-05.2005  0.124
2007 Dalrymple A, Wild EJ, Joubert R, Sathasivam K, Björkqvist M, Petersén A, Jackson GS, Isaacs JD, Kristiansen M, Bates GP, Leavitt BR, Keir G, Ward M, Tabrizi SJ. Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates. Journal of Proteome Research. 6: 2833-40. PMID 17552550 DOI: 10.1021/Pr0700753  0.124
2014 Wang SP, Wu JW, Bourdages H, Lefebvre JF, Casavant S, Leavitt BR, Labuda D, Trasler J, Smith CE, Hermo L, Mitchell GA. The catalytic function of hormone-sensitive lipase is essential for fertility in male mice. Endocrinology. 155: 3047-53. PMID 24797631 DOI: 10.1210/En.2014-1031  0.123
2018 De Souza RAG, Kosior N, Thomson SB, Mathelier A, Zhang AW, Bečanović K, Wasserman WW, Leavitt BR. Computational Analysis of Transcriptional Regulation Sites at the HTT Gene Locus. Journal of Huntington's Disease. 7: 223-237. PMID 30103339 DOI: 10.3233/JHD-170272  0.123
2013 Zhu S, Tai C, Petkau TL, Zhang S, Liao C, Dong Z, Wen W, Chang Q, Tian Wang Y, MacVicar BA, Leavitt BR, Jia W, Cynader MS. Progranulin promotes activation of microglia/macrophage after pilocarpine-induced status epilepticus. Brain Research. 1530: 54-65. PMID 23887054 DOI: 10.1016/J.Brainres.2013.07.023  0.122
2007 Butland SL, Devon RS, Huang Y, Mead CL, Meynert AM, Neal SJ, Lee SS, Wilkinson A, Yang GS, Yuen MM, Hayden MR, Holt RA, Leavitt BR, Ouellette BF. CAG-encoded polyglutamine length polymorphism in the human genome. Bmc Genomics. 8: 126. PMID 17519034 DOI: 10.1186/1471-2164-8-126  0.12
2021 Estevez-Fraga C, Scahill RI, Durr A, Leavitt BR, Roos RAC, Langbehn DR, Rees G, Gregory S, Tabrizi SJ. Composite UHDRS Correlates With Progression of Imaging Biomarkers in Huntington's Disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33471951 DOI: 10.1002/mds.28489  0.118
2006 Van Raamsdonk JM, Gibson WT, Pearson J, Murphy Z, Lu G, Leavitt BR, Hayden MR. Body weight is modulated by levels of full-length huntingtin. Human Molecular Genetics. 15: 1513-23. PMID 16571604 DOI: 10.1093/Hmg/Ddl072  0.117
2021 Jin JW, Fan X, Del Cid-Pellitero E, Liu XX, Zhou L, Dai C, Gibbs E, He W, Li H, Wu X, Hill A, Leavitt BR, Cashman N, Liu L, Lu J, et al. Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson's disease models. Communications Biology. 4: 232. PMID 33608634 DOI: 10.1038/s42003-021-01746-6  0.114
2007 Van Raamsdonk JM, Metzler M, Slow E, Pearson J, Schwab C, Carroll J, Graham RK, Leavitt BR, Hayden MR. Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain. Neurobiology of Disease. 26: 189-200. PMID 17276692 DOI: 10.1016/J.Nbd.2006.12.010  0.113
2013 Reilmann R, Bohlen S, Saß C, Bechtel N, Jauffret C, Sturrock A, Coleman A, Read J, Say M, t’Hart E, van den Bogaard S, Archarya T, Scahill R, Johnson H, Borowsky B, ... ... Leavitt B, et al. Q-motor – Quantitative motor assessments: Potential novel endpoints for clinical trials in pre-manifest and symptomatic Huntington's disease – 36 months longitudinal results from the multicenter TRACK-HD study Basal Ganglia. 3: 67-68. DOI: 10.1016/J.Baga.2013.01.074  0.113
2006 Zhang Y, Leavitt BR, van Raamsdonk JM, Dragatsis I, Goldowitz D, MacDonald ME, Hayden MR, Friedlander RM. Huntingtin inhibits caspase-3 activation. The Embo Journal. 25: 5896-906. PMID 17124493 DOI: 10.1038/Sj.Emboj.7601445  0.112
2017 McColgan P, Razi A, Gregory S, Seunarine KK, Durr A, A C Roos R, Leavitt BR, Scahill RI, Clark CA, Langbehn DR, Rees G, Tabrizi SJ. Structural and functional brain network correlates of depressive symptoms in premanifest Huntington's disease. Human Brain Mapping. PMID 28294457 DOI: 10.1002/Hbm.23527  0.112
2004 Hagerman RJ, Leavitt BR, Farzin F, Jacquemont S, Greco CM, Brunberg JA, Tassone F, Hessl D, Harris SW, Zhang L, Jardini T, Gane LW, Ferranti J, Ruiz L, Leehey MA, et al. Fragile-X-associated tremor/ataxia syndrome (FXTAS) in females with the FMR1 premutation. American Journal of Human Genetics. 74: 1051-6. PMID 15065016 DOI: 10.1086/420700  0.111
2020 Leavitt BR, Tabrizi SJ. Antisense oligonucleotides for neurodegeneration. Science (New York, N.Y.). 367: 1428-1429. PMID 32217715 DOI: 10.1126/science.aba4624  0.111
2015 Hadley Strout E, Fox L, Castro A, Haroun P, Leavitt B, Ross C, Sayan M, Delaney T, Platzer A, Hutchins J, Carney JK. Access to transportation for Chittenden County Vermont older adults. Aging Clinical and Experimental Research. PMID 26542413 DOI: 10.1007/s40520-015-0476-3  0.111
2017 Schobel SA, Palermo G, Auinger P, Long JD, Ma S, Khwaja OS, Trundell D, Cudkowicz M, Hersch S, Sampaio C, Dorsey ER, Leavitt BR, Kieburtz KD, Sevigny JJ, Langbehn DR, et al. Motor, cognitive, and functional declines contribute to a single progressive factor in early HD. Neurology. PMID 29142089 DOI: 10.1212/Wnl.0000000000004743  0.111
2019 Tabrizi SJ, Ghosh R, Leavitt BR. Huntingtin Lowering Strategies for Disease Modification in Huntington's Disease. Neuron. 102: 899. PMID 31121127 DOI: 10.1016/j.neuron.2019.05.001  0.111
2015 Wild EJ, Boggio R, Langbehn D, Robertson N, Haider S, Miller JR, Zetterberg H, Leavitt BR, Kuhn R, Tabrizi SJ, Macdonald D, Weiss A. Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients. The Journal of Clinical Investigation. 125: 1979-86. PMID 25844897 DOI: 10.1172/JCI80743  0.111
2017 Fodale V, Boggio R, Daldin M, Cariulo C, Spiezia MC, Byrne LM, Leavitt BR, Wild E, Macdonald D, Weiss A, Bresciani A. Validation of Ultrasensitive Mutant Huntingtin Detection in Human Cerebrospinal Fluid by Single Molecule Counting Immunoassay. Journal of Huntington's Disease. PMID 29125493 DOI: 10.3233/JHD-170269  0.11
2017 Frost C, Mulick A, Scahill RI, Owen G, Aylward E, Leavitt BR, Durr A, Roos RAC, Borowsky B, Stout JC, Reilmann R, Langbehn DR, Tabrizi SJ, Sampaio C. Design optimization for clinical trials in early-stage manifest Huntington's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 28906031 DOI: 10.1002/Mds.27122  0.11
2005 Puri BK, Leavitt BR, Hayden MR, Ross CA, Rosenblatt A, Greenamyre JT, Hersch S, Vaddadi KS, Sword A, Horrobin DF, Manku M, Murck H. Ethyl-EPA in Huntington disease: a double-blind, randomized, placebo-controlled trial. Neurology. 65: 286-92. PMID 16043801 DOI: 10.1212/01.Wnl.0000169025.09670.6D  0.108
2020 Al-Shekaili HH, Petkau TL, Pena I, Lengyell TC, Verhoeven-Duif NM, Ciapaite J, Bosma M, van Faassen M, Kema IP, Horvath G, Ross C, Simpson EM, Friedman JM, Karnebeek C, Leavitt BR. A Novel Mouse Model for Pyridoxine-Dependent Epilepsy Due to Antiquitin Deficiency. Human Molecular Genetics. PMID 32969477 DOI: 10.1093/hmg/ddaa202  0.106
2017 Long JD, Mills JA, Leavitt BR, Durr A, Roos RA, Stout JC, Reilmann R, Landwehrmeyer B, Gregory S, Scahill RI, Langbehn DR, Tabrizi SJ. Survival End Points for Huntington Disease Trials Prior to a Motor Diagnosis. Jama Neurology. PMID 28975278 DOI: 10.1001/Jamaneurol.2017.2107  0.106
2008 Semaka A, Warby S, Leavitt BR, Hayden MR. Re: Autopsy-proven Huntington's disease with 29 trinucleotide repeats. Movement Disorders : Official Journal of the Movement Disorder Society. 23: 1794-5; author reply. PMID 18548612 DOI: 10.1002/mds.21820  0.105
2008 Wagner LA, Menalled L, Goumeniouk AD, Brunner D, Leavitt BR. Huntington disease Animal and Translational Models For Cns Drug Discovery. 2: 207-266. DOI: 10.1016/B978-0-12-373861-5.00018-7  0.105
2023 Aggarwal G, Banerjee S, Jones SA, Benchaar Y, Bélanger J, Sévigny M, Smith DM, Niehoff ML, Pavlack M, de Vera IMS, Petkau TL, Leavitt BR, Ling K, Jafar-Nejad P, Rigo F, et al. Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation. The Journal of Biological Chemistry. 105475. PMID 37981208 DOI: 10.1016/j.jbc.2023.105475  0.103
2012 Dumas EM, Say MJ, Jones R, Labuschagne I, O'Regan AM, Hart EP, van den Bogaard SJ, Queller S, Justo D, Coleman A, Dar Santos RC, Dürr A, Leavitt BR, Tabrizi SJ, Roos RA, et al. Visual Working Memory Impairment in Premanifest Gene-Carriers and Early Huntington's Disease. Journal of Huntington's Disease. 1: 97-106. PMID 25063192 DOI: 10.3233/JHD-2012-120010  0.102
2021 Engelke UF, van Outersterp RE, Merx J, van Geenen FA, van Rooij A, Berden G, Huigen MC, Kluijtmans LA, Peters TM, Al-Shekaili HH, Leavitt BR, de Vrieze E, Broekman S, van Wijk E, Tseng LA, et al. Untargeted metabolomics and infrared ion spectroscopy identify biomarkers for pyridoxine-dependent epilepsy. The Journal of Clinical Investigation. PMID 34138754 DOI: 10.1172/JCI148272  0.102
2001 Singaraja RR, Bocher V, James ER, Clee SM, Zhang LH, Leavitt BR, Tan B, Brooks-Wilson A, Kwok A, Bissada N, Yang YZ, Liu G, Tafuri SR, Fievet C, Wellington CL, et al. Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and ApoAI-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1. The Journal of Biological Chemistry. 276: 33969-79. PMID 11423537 DOI: 10.1074/Jbc.M102503200  0.102
2018 Andrews SC, Craufurd D, Durr A, Leavitt BR, Roos RA, Tabrizi SJ, Stout JC. Executive impairment is associated with unawareness of neuropsychiatric symptoms in premanifest and early Huntington's disease. Neuropsychology. PMID 30211612 DOI: 10.1037/neu0000479  0.102
2022 Frank S, Testa C, Edmondson MC, Goldstein J, Kayson E, Leavitt BR, Oakes D, O'Neill C, Vaughan C, Whaley J, Gross N, Gordon MF, Savola JM. The Safety of Deutetrabenazine for Chorea in Huntington Disease: An Open-Label Extension Study. Cns Drugs. PMID 36242718 DOI: 10.1007/s40263-022-00956-8  0.101
2009 Yeretssian G, Doiron K, Shao W, Leavitt BR, Hayden MR, Nicholson DW, Saleh M. Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infection. Proceedings of the National Academy of Sciences of the United States of America. 106: 9016-20. PMID 19447924 DOI: 10.1073/Pnas.0813362106  0.101
2019 Ciosi M, Maxwell A, Cumming SA, Hensman Moss DJ, Alshammari AM, Flower MD, Durr A, Leavitt BR, Roos RAC, Holmans P, Jones L, Langbehn DR, Kwak S, et al. A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with Huntington disease clinical outcomes. Ebiomedicine. PMID 31607598 DOI: 10.1016/j.ebiom.2019.09.020  0.101
2022 Chan LL, Hill A, Lu G, Van Raamsdonk J, Gascoyne R, Hayden MR, Leavitt BR. Huntingtin Overexpression Does Not Alter Overall Survival in Murine Cancer Models. Journal of Huntington's Disease. PMID 36442204 DOI: 10.3233/JHD-220554  0.1
2006 Leavitt BR, Hayden MR. Is tetrabenazine safe and effective for suppressing chorea in Huntington's disease? Nature Clinical Practice. Neurology. 2: 536-7. PMID 16990826 DOI: 10.1038/Ncpneuro0299  0.1
2005 Missirlis PI, Mead CL, Butland SL, Ouellette BF, Devon RS, Leavitt BR, Holt RA. Satellog: a database for the identification and prioritization of satellite repeats in disease association studies. Bmc Bioinformatics. 6: 145. PMID 15949044 DOI: 10.1186/1471-2105-6-145  0.099
2012 Stout JC, Jones R, Labuschagne I, O'Regan AM, Say MJ, Dumas EM, Queller S, Justo D, Santos RD, Coleman A, Hart EP, Dürr A, Leavitt BR, Roos RA, Langbehn DR, et al. Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease. Journal of Neurology, Neurosurgery, and Psychiatry. 83: 687-94. PMID 22566599 DOI: 10.1136/jnnp-2011-301940  0.098
2016 Keogh R, Frost C, Owen G, Daniel RM, Langbehn DR, Leavitt B, Durr A, Roos RA, Landwehrmeyer GB, Reilmann R, Borowsky B, Stout J, Craufurd D, Tabrizi SJ. Medication Use in Early-HD Participants in Track-HD: an Investigation of its Effects on Clinical Performance. Plos Currents. 8. PMID 26819833 DOI: 10.1371/Currents.Hd.8060298Fac1801B01Ccea6Acc00F97Cb  0.098
2014 Saft C, Leavitt BR, Epplen JT. Clinical utility gene card for: Huntington's disease. European Journal of Human Genetics : Ejhg. 22. PMID 24105375 DOI: 10.1038/ejhg.2013.206  0.098
2014 Plecash AR, Leavitt BR. Aquatherapy for neurodegenerative disorders. Journal of Huntington's Disease. 3: 5-11. PMID 25062761 DOI: 10.3233/JHD-140010  0.096
2015 Angus D, Herd C, Stone C, Stout J, Wieler M, Reilmann R, Ritchie CW, Dorsey ER, Helles K, Kayson E, Oakes D, Rosas HD, Vaughan C, Panegyres PK, Ames D, ... ... Leavitt BR, et al. Safety, tolerability, and efficacy of PBT2 in Huntington's disease: A phase 2, randomised, double-blind, placebo-controlled trial The Lancet Neurology. 14: 39-47. PMID 25467848 DOI: 10.1016/S1474-4422(14)70262-5  0.096
2015 Cunniff B, Newick K, Nelson KJ, Wozniak AN, Beuschel S, Leavitt B, Bhave A, Butnor K, Koenig A, Chouchani ET, James AM, Haynes AC, Lowther WT, Murphy MP, Shukla A, et al. Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma. Plos One. 10: e0127310. PMID 26011724 DOI: 10.1371/Journal.Pone.0127310  0.096
2021 Bečanović K, Asghar M, Gadawska I, Sachdeva S, Walker D, Lazarowski ER, Franciosi S, Park KHJ, Côté HCF, Leavitt BR. Author Correction: Age-related mitochondrial alterations in brain and skeletal muscle of the YAC128 model of Huntington disease. Npj Aging and Mechanisms of Disease. 7: 27. PMID 34876577 DOI: 10.1038/s41514-021-00080-9  0.096
2009 Sturrock A, Leavitt BR. Murine models of Huntington disease Future Neurology. 4: 617-638. DOI: 10.2217/fnl.09.34  0.095
2012 Leavitt BR, Thompson LM. Journal of Huntington's Disease. Journal of Huntington's Disease. 1: 1. PMID 25056612 DOI: 10.3233/JHD-2012-120001  0.092
1998 O'Connor GT, Birkmeyer JD, Dacey LJ, Quinton HB, Marrin CA, Birkmeyer NJ, Morton JR, Leavitt BJ, Maloney CT, Hernandez F, Clough RA, Nugent WC, Olmstead EM, Charlesworth DC, Plume SK. Results of a regional study of modes of death associated with coronary artery bypass grafting. Northern New England Cardiovascular Disease Study Group. The Annals of Thoracic Surgery. 66: 1323-8. PMID 9800828 DOI: 10.1016/S0003-4975(98)00762-0  0.092
2013 Leavitt BR, Thompson LM. We are pleased to introduce this next volume of the Journal of Huntington's Disease. Introduction. Journal of Huntington's Disease. 2: 1. PMID 25057106 DOI: 10.3233/JHD-130003  0.092
2013 Borowsky B, Warner J, Leavitt BR, Tabrizi SJ, Roos RA, Durr A, Becker C, Sampaio C, Tobin AJ, Schulman H. 8OHdG is not a biomarker for Huntington disease state or progression. Neurology. 80: 1934-41. PMID 23616162 DOI: 10.1212/WNL.0b013e318293e1a1  0.092
2005 Ander S, MacLennan M, Bentil S, Leavitt B, Chesler N. Pressure-induced vector transport in human saphenous vein. Annals of Biomedical Engineering. 33: 202-8. PMID 15771273 DOI: 10.1007/S10439-005-8978-3  0.089
2021 Kulkarni JA, Witzigmann D, Thomson SB, Chen S, Leavitt BR, Cullis PR, van der Meel R. The current landscape of nucleic acid therapeutics. Nature Nanotechnology. PMID 34059811 DOI: 10.1038/s41565-021-00898-0  0.088
2001 Leavitt BJ, O'Connor GT, Olmstead EM, Morton JR, Maloney CT, Dacey LJ, Hernandez F, Lahey SJ. Use of the internal mammary artery graft and in-hospital mortality and other adverse outcomes associated with coronary artery bypass surgery. Circulation. 103: 507-12. PMID 11157714 DOI: 10.1161/01.CIR.103.4.507  0.087
1997 Schneider DJ, Ricci MA, Taatjes DJ, Baumann PQ, Reese JC, Leavitt BJ, Absher PM, Sobel BE. Changes in arterial expression of fibrinolytic system proteins in atherogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology. 17: 3294-301. PMID 9409325 DOI: 10.1161/01.ATV.17.11.3294  0.087
2015 Wagner L, Wolf R, Zeitschel U, Rossner S, Petersén Å, Leavitt BR, Kästner F, Rothermundt M, Gärtner UT, Gündel D, Schlenzig D, Frerker N, Schade J, Manhart S, Rahfeld JU, et al. Proteolytic degradation of neuropeptide Y (NPY) from head to toe: Identification of novel NPY-cleaving peptidases and potential drug interactions in CNS and Periphery. Journal of Neurochemistry. PMID 26442809 DOI: 10.1111/Jnc.13378  0.086
1996 Birkmeyer JD, Quinton HB, O'Connor NJ, McDaniel MD, Leavitt BJ, Charlesworth DC, Hernandez F, Ricci MA, O'Connor GT. The effect of peripheral vascular disease on long-term mortality after coronary artery bypass surgery. Northern New England Cardiovascular Disease Study Group. Archives of Surgery (Chicago, Ill. : 1960). 131: 316-21. PMID 8611098 DOI: 10.1001/Archsurg.1996.01430150094018  0.085
1998 Dacey LJ, Munoz JJ, Baribeau YR, Johnson ER, Lahey SJ, Leavitt BJ, Quinn RD, Nugent WC, Birkmeyer JD, O'Connor GT. Reexploration for hemorrhage following coronary artery bypass grafting: incidence and risk factors. Northern New England Cardiovascular Disease Study Group. Archives of Surgery (Chicago, Ill. : 1960). 133: 442-7. PMID 9565127 DOI: 10.1001/Archsurg.133.4.442  0.084
2015 Biglan KM, Shoulson I, Kieburtz K, Oakes D, Kayson E, Shinaman MA, Zhao H, Romer M, Young A, Hersch S, Penney J, Marder K, Paulsen J, Quaid K, ... ... Leavitt B, et al. Clinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS): Implications for Clinical Trials. Jama Neurology. 1-9. PMID 26569098 DOI: 10.1001/Jamaneurol.2015.2736  0.084
2009 Krag DN, Kusminsky R, Manna E, Weaver D, Harlow SP, Covelli M, Stanley MA, McCahill L, Ittleman F, Leavitt B, Krag M, Amarante P. Cytokeratin-positive cells in the bone marrow of breast cancer patients and noncancer donors. Applied Immunohistochemistry & Molecular Morphology : Aimm / Official Publication of the Society For Applied Immunohistochemistry. 17: 403-8. PMID 19417625 DOI: 10.1097/PAI.0b013e31819f4d6b  0.082
2015 Howard AK, Krishnamoorthy A, Leavitt BR, Raymond LA, Weissman CR. Treatment of Huntington Disease and Comorbid Trichotillomania With Aripiprazole. The Journal of Neuropsychiatry and Clinical Neurosciences. 27: e211-2. PMID 26222972 DOI: 10.1176/appi.neuropsych.14090232  0.082
2014 Reilmann R, Leavitt BR, Ross CA. Huntington's disease: a field on the move. Introduction. Movement Disorders : Official Journal of the Movement Disorder Society. 29: 1333-4. PMID 25164859 DOI: 10.1002/Mds.26017  0.08
2010 Brown JR, MacKenzie TA, Dacey LJ, Leavitt BJ, Braxton JH, Westbrook BM, Helm RE, Klemperer JD, Frumiento C, Sardella GL, Ross CS, O'Connor GT. Using biomarkers to improve the preoperative prediction of death in coronary artery bypass graft patients. The Journal of Extra-Corporeal Technology. 42: 293-300. PMID 21313927  0.08
2003 Dacey LJ, DeSimone J, Braxton JH, Leavitt BJ, Lahey SJ, Klemperer JD, Westbrook BM, Olmstead EM, O'Connor GT. Preoperative white blood cell count and mortality and morbidity after coronary artery bypass grafting. The Annals of Thoracic Surgery. 76: 760-4. PMID 12963194 DOI: 10.1016/S0003-4975(03)00675-1  0.079
1997 Leavitt BJ, Olmstead EM, Plume SK, Charlesworth DC, Maislen EL, James TW, Baribeau YR, Quinn R, O'Connor GT. Use of the internal mammary artery graft in Northern New England. Northern New England Cardiovascular Disease Study Group. Circulation. 96: II-32-6; discussion . PMID 9386072  0.079
2003 Charlesworth DC, Likosky DS, Marrin CA, Maloney CT, Quinton HB, Morton JR, Leavitt BJ, Clough RA, O'Connor GT. Development and validation of a prediction model for strokes after coronary artery bypass grafting. The Annals of Thoracic Surgery. 76: 436-43. PMID 12902080 DOI: 10.1016/S0003-4975(03)00528-9  0.079
2007 Brown JR, Cochran RP, Leavitt BJ, Dacey LJ, Ross CS, MacKenzie TA, Kunzelman KS, Kramer RS, Hernandez F, Helm RE, Westbrook BM, Dunton RF, Malenka DJ, O'Connor GT. Multivariable prediction of renal insufficiency developing after cardiac surgery. Circulation. 116: I139-43. PMID 17846294 DOI: 10.1161/Circulationaha.106.677070  0.079
2008 Brown JR, Cochran RP, MacKenzie TA, Furnary AP, Kunzelman KS, Ross CS, Langner CW, Charlesworth DC, Leavitt BJ, Dacey LJ, Helm RE, Braxton JH, Clough RA, Dunton RF, O'Connor GT, et al. Long-term survival after cardiac surgery is predicted by estimated glomerular filtration rate. The Annals of Thoracic Surgery. 86: 4-11. PMID 18573389 DOI: 10.1016/J.Athoracsur.2008.03.006  0.078
2002 Mulieri LA, Barnes W, Leavitt BJ, Ittleman FP, LeWinter MM, Alpert NR, Maughan DW. Alterations of myocardial dynamic stiffness implicating abnormal crossbridge function in human mitral regurgitation heart failure. Circulation Research. 90: 66-72. PMID 11786520  0.077
2006 Brown JR, Cochran RP, Dacey LJ, Ross CS, Kunzelman KS, Dunton RF, Braxton JH, Charlesworth DC, Clough RA, Helm RE, Leavitt BJ, Mackenzie TA, O'Connor GT. Perioperative increases in serum creatinine are predictive of increased 90-day mortality after coronary artery bypass graft surgery. Circulation. 114: I409-13. PMID 16820609 DOI: 10.1161/Circulationaha.105.000596  0.076
2010 Petkau T, Neal SJ, Milnerwood A, Orban PC, Feldman HH, Raymond L, Mackenzie IR, Leavitt BR. S1-02-03: Generation and characterization of a mouse model of progranulin deficiency Alzheimer's & Dementia. 6: S65-S65. DOI: 10.1016/J.Jalz.2010.05.190  0.075
2002 Dacey LJ, Liu JY, Braxton JH, Weintraub RM, DeSimone J, Charlesworth DC, Lahey SJ, Ross CS, Hernandez F, Leavitt BJ, O'Connor GT. Long-term survival of dialysis patients after coronary bypass grafting. The Annals of Thoracic Surgery. 74: 458-62; discussion 4. PMID 12173829 DOI: 10.1016/S0003-4975(02)03768-2  0.074
2015 Becanovic K, Nørremølle A, Neal SJ, Kay C, Collins JA, Arenillas D, Lilja T, Gaudenzi G, Manoharan S, Doty CN, Beck J, Lahiri N, Portales-Casamar E, Warby SC, Connolly C, ... ... Leavitt BR, et al. A SNP in the HTT promoter alters NF-κB binding and is a bidirectional genetic modifier of Huntington disease Nature Neuroscience. 18: 807-816. DOI: 10.1038/nn.4014  0.074
2011 Likosky DS, Surgenor SD, Kramer RS, Russo L, Leavitt BJ, Sorensen MJ, Helm RE, Sardella GL, Dipierro FV, Baribeau YR, Malenka DJ, Mackenzie TA, Brown JR, Ross CS. Effect of prior cardiac operations on survival after coronary artery bypass grafting. The Annals of Thoracic Surgery. 92: 1260-7. PMID 21958769 DOI: 10.1016/j.athoracsur.2011.05.111  0.073
2006 Björkqvist M, Petersén A, Nielsen J, Ecker D, Mulder H, Hayden MR, Landwehrmeyer B, Brundin P, Leavitt BR. Cerebrospinal fluid levels of orexin-A are not a clinically useful biomarker for Huntington disease. Clinical Genetics. 70: 78-9. PMID 16813610 DOI: 10.1111/J.1399-0004.2006.00636.X  0.073
2003 Noguchi T, Camp P, Alix SL, Gorga JA, Begin KJ, Leavitt BJ, Ittleman FP, Alpert NR, LeWinter MM, VanBuren P. Myosin from failing and non-failing human ventricles exhibit similar contractile properties. Journal of Molecular and Cellular Cardiology. 35: 91-7. PMID 12623303 DOI: 10.1016/S0022-2828(02)00282-1  0.072
2004 Viña A, Gitelson AA, Rundquist DC, Keydan G, Leavitt B, Schepers J. Monitoring maize (Zea mays L.) phenology with remote sensing Agronomy Journal. 96: 1139-1147. DOI: 10.2134/Agronj2004.1139  0.072
1997 Mulieri LA, Leavitt BJ, Wright RK, Alpert NR. Role of cAMP in modulating relaxation kinetics and the force-frequency relation in mitral regurgitation heart failure. Basic Research in Cardiology. 92: 95-103. PMID 9202849  0.072
2001 Surgenor SD, O'Connor GT, Lahey SJ, Quinn R, Charlesworth DC, Dacey LJ, Clough RA, Leavitt BJ, Defoe GR, Fillinger M, Nugent WC. Predicting the risk of death from heart failure after coronary artery bypass graft surgery. Anesthesia and Analgesia. 92: 596-601. PMID 11226084 DOI: 10.1097/00000539-200103000-00008  0.072
2005 Krag DN, Kusminsky R, Manna E, Ambaye A, Weaver DL, Harlow SP, Covelli M, Stanley MA, McCahill L, Ittleman F, Leavitt B, Krag M. The detection of isolated tumor cells in bone marrow comparing bright-field immunocytochemistry and multicolor immunofluorescence. Annals of Surgical Oncology. 12: 753-60. PMID 16079954 DOI: 10.1245/ASO.2005.12.004  0.071
2008 O'Connor GT, Olmstead EM, Nugent WC, Leavitt BJ, Clough RA, Weldner PW, Charlesworth DC, Chaisson K, Sisto D, Nowicki ER, Cochran RP, Malenka DJ. Appropriateness of coronary artery bypass graft surgery performed in northern New England. Journal of the American College of Cardiology. 51: 2323-8. PMID 18549917 DOI: 10.1016/J.Jacc.2008.01.067  0.071
2005 Malenka DJ, Leavitt BJ, Hearne MJ, Robb JF, Baribeau YR, Ryan TJ, Helm RE, Kellett MA, Dauerman HL, Dacey LJ, Silver MT, VerLee PN, Weldner PW, Hettleman BD, Olmstead EM, et al. Comparing long-term survival of patients with multivessel coronary disease after CABG or PCI: analysis of BARI-like patients in northern New England. Circulation. 112: I371-6. PMID 16159849 DOI: 10.1161/CIRCULATIONAHA.104.526392  0.068
2007 Dacey LJ, Likosky DS, Ryan TJ, Robb JF, Quinn RD, DeVries JT, Hearne MJ, Leavitt BJ, Dunton RF, Clough RA, Sisto D, Ross CS, Olmstead EM, O'Connor GT, Malenka DJ, et al. Long-term survival after surgery versus percutaneous intervention in octogenarians with multivessel coronary disease. The Annals of Thoracic Surgery. 84: 1904-11; discussion . PMID 18036905 DOI: 10.1016/j.athoracsur.2007.07.013  0.068
1996 O'Connor GT, Plume SK, Olmstead EM, Morton JR, Maloney CT, Nugent WC, Hernandez F, Clough R, Leavitt BJ, Coffin LH, Marrin CA, Wennberg D, Birkmeyer JD, Charlesworth DC, Malenka DJ, et al. A regional intervention to improve the hospital mortality associated with coronary artery bypass graft surgery. The Northern New England Cardiovascular Disease Study Group. Jama. 275: 841-6. PMID 8596221 DOI: 10.1001/jama.275.11.841  0.068
2001 DeFoe GR, Ross CS, Olmstead EM, Surgenor SD, Fillinger MP, Groom RC, Forest RJ, Pieroni JW, Warren CS, Bogosian ME, Krumholz CF, Clark C, Clough RA, Weldner PW, Lahey SJ, ... Leavitt BJ, et al. Lowest hematocrit on bypass and adverse outcomes associated with coronary artery bypass grafting. Northern New England Cardiovascular Disease Study Group. The Annals of Thoracic Surgery. 71: 769-76. PMID 11269449 DOI: 10.1016/S0003-4975(00)02393-6  0.067
2015 Callaghan J, Stopford C, Arran N, Boisse MF, Coleman A, Santos RD, Dumas EM, Hart EP, Justo D, Owen G, Read J, Say MJ, Durr A, Leavitt BR, Roos RA, et al. Reliability and factor structure of the Short Problem Behaviors Assessment for Huntington's disease (PBA-s) in the TRACK-HD and REGISTRY studies. The Journal of Neuropsychiatry and Clinical Neurosciences. 27: 59-64. PMID 25716488 DOI: 10.1176/appi.neuropsych.13070169  0.066
2007 Wong D, Dwinnel M, Schulzer M, Nimmo M, Leavitt BR, Spacey SD. Ataxia and the role of antigliadin antibodies. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 34: 193-6. PMID 17598597  0.065
1998 Alpert NR, Leavitt BJ, Ittleman FP, Hasenfuss G, Pieske B, Mulieri LA. A mechanistic analysis of the force-frequency relation in non-failing and progressively failing human myocardium. Basic Research in Cardiology. 93: 23-32. PMID 9833127  0.065
2019 Ross CA, Reilmann R, Cardoso F, McCusker EA, Testa CM, Stout JC, Leavitt BR, Pei Z, Landwehrmeyer B, Martinez A, Levey J, Srajer T, Bang J, Tabrizi SJ. Movement Disorder Society Task Force Viewpoint: Huntington's Disease Diagnostic Categories. Movement Disorders Clinical Practice. 6: 541-546. PMID 31538087 DOI: 10.1002/Mdc3.12808  0.064
2006 Surgenor SD, DeFoe GR, Fillinger MP, Likosky DS, Groom RC, Clark C, Helm RE, Kramer RS, Leavitt BJ, Klemperer JD, Krumholz CF, Westbrook BM, Galatis DJ, Frumiento C, Ross CS, et al. Intraoperative red blood cell transfusion during coronary artery bypass graft surgery increases the risk of postoperative low-output heart failure. Circulation. 114: I43-8. PMID 16820613 DOI: 10.1161/CIRCULATIONAHA.105.001271  0.063
2009 Leavitt BJ, Baribeau YR, DiScipio AW, Ross CS, Quinn RD, Olmstead EM, Sisto D, Likosky DS, Cochran RP, Clough RA, Boss RA, Kramer RS, O'Connor GT. Outcomes of patients undergoing concomitant aortic and mitral valve surgery in northern new England. Circulation. 120: S155-62. PMID 19752361 DOI: 10.1161/Circulationaha.108.843573  0.063
1997 Rogers FB, Leavitt BJ. Upper torso cyanosis: a marker for blunt cardiac rupture. The American Journal of Emergency Medicine. 15: 275-6. PMID 9148985  0.063
2008 Likosky DS, Dacey LJ, Baribeau YR, Leavitt BJ, Clough R, Cochran RP, Quinn R, Sisto DA, Charlesworth DC, Malenka DJ, MacKenzie TA, Olmstead EM, Ross CS, O'Connor GT. Long-term survival of the very elderly undergoing coronary artery bypass grafting. The Annals of Thoracic Surgery. 85: 1233-7. PMID 18355501 DOI: 10.1016/j.athoracsur.2007.12.066  0.062
2007 Gitelson AA, Wardlow BD, Keydan GP, Leavitt B. An evaluation of MODIS 250-m data for green LAI estimation in crops Geophysical Research Letters. 34. DOI: 10.1029/2007Gl031620  0.062
2005 Mulieri LA, Tischler MD, Martin BJ, Leavitt BJ, Ittleman FP, Alpert NR, LeWinter MM. Regional differences in the force-frequency relation of human left ventricular myocardium in mitral regurgitation: implications for ventricular shape. American Journal of Physiology. Heart and Circulatory Physiology. 288: H2185-91. PMID 15637116 DOI: 10.1152/ajpheart.00905.2003  0.062
1992 Alpert NR, Hasenfuss G, Mulieri LA, Blanchard EM, Leavitt BJ, Ittleman F. The reorganization of the human and rabbit heart in response to haemodynamic overload. European Heart Journal. 13: 9-16. PMID 1396867  0.061
2001 Leavitt B. Shedding new light on the pathogenesis of familial Alzheimer disease Clinical Genetics. 58: 266-268. DOI: 10.1034/j.1399-0004.2000.580403.2.x  0.061
1992 Hasenfuss G, Mulieri LA, Leavitt BJ, Allen PD, Holubarsch C, Just H, Alpert NR. Contractile protein function in failing and nonfailing human myocardium. Basic Research in Cardiology. 87: 107-16. PMID 1497566  0.06
2014 Mazarei G, Leavitt BR. Murine Models of HD Movement Disorders: Genetics and Models: Second Edition. 533-546. DOI: 10.1016/B978-0-12-405195-9.00031-7  0.059
2000 Liu JY, Birkmeyer NJ, Sanders JH, Morton JR, Henriques HF, Lahey SJ, Dow RW, Maloney C, DiScipio AW, Clough R, Leavitt BJ, O'Connor GT. Risks of morbidity and mortality in dialysis patients undergoing coronary artery bypass surgery. Northern New England Cardiovascular Disease Study Group. Circulation. 102: 2973-7. PMID 11113048 DOI: 10.1161/01.CIR.102.24.2973  0.059
2010 Robert AM, Kramer RS, Dacey LJ, Charlesworth DC, Leavitt BJ, Helm RE, Hernandez F, Sardella GL, Frumiento C, Likosky DS, Brown JR. Cardiac surgery-associated acute kidney injury: a comparison of two consensus criteria. The Annals of Thoracic Surgery. 90: 1939-43. PMID 21095340 DOI: 10.1016/j.athoracsur.2010.08.018  0.057
2012 Yun JJ, Helm RE, Kramer RS, Leavitt BJ, Surgenor SD, DiScipio AW, Dacey LJ, Baribeau YR, Russo L, Sardella GL, Charlesworth DC, Clough RA, DeSimone JP, Ross CS, Malenka DJ, et al. Limited blood transfusion does not impact survival in octogenarians undergoing cardiac operations. The Annals of Thoracic Surgery. 94: 2038-45. PMID 22959580 DOI: 10.1016/j.athoracsur.2012.06.059  0.056
1995 Birkmeyer JD, O'Connor GT, Quinton HB, Ricci MA, Morton JR, Leavitt BJ, Charlesworth DC, Hernandez F, McDaniel MD. The effect of peripheral vascular disease on in-hospital mortality rates with coronary artery bypass surgery. Northern New England Cardiovascular Disease Study Group. Journal of Vascular Surgery. 21: 445-52. PMID 7877226 DOI: 10.1016/S0741-5214(95)70286-5  0.056
1991 Hasenfuss G, Mulieri LA, Blanchard EM, Holubarsch C, Leavitt BJ, Ittleman F, Alpert NR. Energetics of isometric force development in control and volume-overload human myocardium. Comparison with animal species. Circulation Research. 68: 836-46. PMID 1742869  0.055
1996 Nguyen TT, Hayes E, Mulieri LA, Leavitt BJ, ter Keurs HE, Alpert NR, Warshaw DM. Maximal actomyosin ATPase activity and in vitro myosin motility are unaltered in human mitral regurgitation heart failure. Circulation Research. 79: 222-6. PMID 8755998  0.055
2012 Likosky DS, Goldberg JB, DiScipio AW, Kramer RS, Groom RC, Leavitt BJ, Surgenor SD, Baribeau YR, Charlesworth DC, Helm RE, Frumiento C, Sardella GL, Clough RA, MacKenzie TA, Malenka DJ, et al. Variability in surgeons' perioperative practices may influence the incidence of low-output failure after coronary artery bypass grafting surgery. Circulation. Cardiovascular Quality and Outcomes. 5: 638-44. PMID 22828825 DOI: 10.1161/CIRCOUTCOMES.112.967091  0.054
2000 Dacey LJ, Munoz JJ, Johnson ER, Leavitt BJ, Maloney CT, Morton JR, Olmstead EM, Birkmeyer JD, O'Connor GT. Effect of preoperative aspirin use on mortality in coronary artery bypass grafting patients. The Annals of Thoracic Surgery. 70: 1986-90. PMID 11156107 DOI: 10.1016/S0003-4975(00)02133-0  0.054
2022 Kazemian P, Yu SY, Thomson SB, Birkenshaw A, Leavitt BR, Ross CJD. Lipid-Nanoparticle-Based Delivery of CRISPR/Cas9 Genome-Editing Components. Molecular Pharmaceutics. 19: 1669-1686. PMID 35594500 DOI: 10.1021/acs.molpharmaceut.1c00916  0.054
2003 Krupp M, Cantoni G, Leavitt B, Mazzatenta E, Babcock L, Cook K. STC≱0 - The golden opportunity continues Proceedings/Stc, Society For Technical Communication Annual Conference. 116-118.  0.053
2006 Leavitt BJ, Ross CS, Spence B, Surgenor SD, Olmstead EM, Clough RA, Charlesworth DC, Kramer RS, O'Connor GT. Long-term survival of patients with chronic obstructive pulmonary disease undergoing coronary artery bypass surgery. Circulation. 114: I430-4. PMID 16820614 DOI: 10.1161/CIRCULATIONAHA.105.000943  0.052
2004 Noguchi T, Hünlich M, Camp PC, Begin KJ, El-Zaru M, Patten R, Leavitt BJ, Ittleman FP, Alpert NR, LeWinter MM, VanBuren P. Thin-filament-based modulation of contractile performance in human heart failure. Circulation. 110: 982-7. PMID 15302786 DOI: 10.1161/01.CIR.0000139334.43109.F9  0.052
1992 Hasenfuss G, Mulieri LA, Leavitt BJ, Allen PD, Haeberle JR, Alpert NR. Alteration of contractile function and excitation-contraction coupling in dilated cardiomyopathy. Circulation Research. 70: 1225-32. PMID 1576741  0.052
2003 Nowicki ER, Weintraub RW, Birkmeyer NJ, Sanders JH, Dacey LJ, Lahey SJ, Leavitt B, Clough RA, Quinn RD, O'connor GT. Mitral valve repair and replacement in northern New England. American Heart Journal. 145: 1058-62. PMID 12796763 DOI: 10.1016/S0002-8703(02)94721-6  0.052
2004 Nowicki ER, Birkmeyer NJ, Weintraub RW, Leavitt BJ, Sanders JH, Dacey LJ, Clough RA, Quinn RD, Charlesworth DC, Sisto DA, Uhlig PN, Olmstead EM, O'Connor GT. Multivariable prediction of in-hospital mortality associated with aortic and mitral valve surgery in Northern New England. The Annals of Thoracic Surgery. 77: 1966-77. PMID 15172248 DOI: 10.1016/J.Athoracsur.2003.12.035  0.052
2005 Dacey LJ, Likosky DS, Leavitt BJ, Lahey SJ, Quinn RD, Hernandez F, Quinton HB, Desimone JP, Ross CS, O'Connor GT. Perioperative stroke and long-term survival after coronary bypass graft surgery. The Annals of Thoracic Surgery. 79: 532-6; discussion 53. PMID 15680829 DOI: 10.1016/J.Athoracsur.2004.07.027  0.051
1987 Leavitt BJ, Meyer JA, Morton JR, Clark DE, Herbert WE, Hiebert CA. Survival following nonpenetrating traumatic rupture of cardiac chambers. The Annals of Thoracic Surgery. 44: 532-5. PMID 3314758 DOI: 10.1016/S0003-4975(10)62116-9  0.051
2017 No H, Gagne H, Nelson C, Kinsey M, Garrison G, Kikut J, Gentchos G, Seward D, Sidiropoulos N, Folefac E, Leavitt B, Ashikaga T, Dragnev K, Lin S, Anker C. Effect of Tumor Volume Doubling Time on Prognosis for Stage I Non–small Cell Lung Cancers International Journal of Radiation Oncology*Biology*Physics. 99: E487. DOI: 10.1016/j.ijrobp.2017.06.1766  0.051
2007 Leavitt BJ. The effects of diabetes mellitus on coronary artery bypass graft surgery. Current Diabetes Reports. 7: 20-4. PMID 17254514 DOI: 10.1007/s11892-007-0005-7  0.05
2023 Leavitt BR, Thompson LM. Preface to the Special Issue on "Sleep and Circadian Disorder in Huntington's Disease". Journal of Huntington's Disease. 12: 89. PMID 37483022 DOI: 10.3233/JHD-239002  0.05
2002 Clough RA, Leavitt BJ, Morton JR, Plume SK, Hernandez F, Nugent W, Lahey SJ, Ross CS, O'Connor GT. The effect of comorbid illness on mortality outcomes in cardiac surgery. Archives of Surgery (Chicago, Ill. : 1960). 137: 428-32; discussion 4. PMID 11926947 DOI: 10.1001/Archsurg.137.4.428  0.049
2009 Surgenor SD, Kramer RS, Olmstead EM, Ross CS, Sellke FW, Likosky DS, Marrin CA, Helm RE, Leavitt BJ, Morton JR, Charlesworth DC, Clough RA, Hernandez F, Frumiento C, Benak A, et al. The association of perioperative red blood cell transfusions and decreased long-term survival after cardiac surgery. Anesthesia and Analgesia. 108: 1741-6. PMID 19448195 DOI: 10.1213/Ane.0B013E3181A2A696  0.049
2004 Leavitt BJ, Sheppard L, Maloney C, Clough RA, Braxton JH, Charlesworth DC, Weintraub RM, Hernandez F, Olmstead EM, Nugent WC, O'Connor GT, Ross CS. Effect of diabetes and associated conditions on long-term survival after coronary artery bypass graft surgery. Circulation. 110: II41-4. PMID 15364836 DOI: 10.1161/01.CIR.0000138197.07051.e7  0.048
2000 Alpert NR, Hasenfuss G, Leavitt BJ, Ittleman FP, Pieske B, Mulieri LA. A mechanistic analysis of reduced mechanical performance in human heart failure. Japanese Heart Journal. 41: 103-15. PMID 10850527  0.048
2005 Corbett SM, Rebuck JA, Greene CM, Callas PW, Neale BW, Healey MA, Leavitt BJ. Dexmedetomidine does not improve patient satisfaction when compared with propofol during mechanical ventilation. Critical Care Medicine. 33: 940-5. PMID 15891317 DOI: 10.1097/01.CCM.0000162565.18193.E5  0.048
2009 Likosky DS, Sorensen MJ, Dacey LJ, Baribeau YR, Leavitt BJ, DiScipio AW, Hernandez F, Cochran RP, Quinn R, Helm RE, Charlesworth DC, Clough RA, Malenka DJ, Sisto DA, Sardella G, et al. Long-term survival of the very elderly undergoing aortic valve surgery. Circulation. 120: S127-33. PMID 19752357 DOI: 10.1161/Circulationaha.108.842641  0.047
2008 Killgore WD, Grugle NL, Killgore DB, Leavitt BP, Watlington GI, McNair S, Balkin TJ. Restoration of risk-propensity during sleep deprivation: caffeine, dextroamphetamine, and modafinil. Aviation, Space, and Environmental Medicine. 79: 867-74. PMID 18785355 DOI: 10.3357/Asem.2259.2008  0.047
2013 Nguy-Robertson A, Gitelson A, Peng Y, Walter-Shea E, Leavitt B, Arkebauer T. Continuous monitoring of crop reflectance, vegetation fraction, and identification of developmental stages using a four band radiometer Agronomy Journal. 105: 1769-1779. DOI: 10.2134/Agronj2013.0242  0.047
2013 Zlotnick DM, Ouellette ML, Malenka DJ, DeSimone JP, Leavitt BJ, Helm RE, Olmstead EM, Costa SP, DiScipio AW, Likosky DS, Schmoker JD, Quinn RD, Sisto D, Klemperer JD, Sardella GL, et al. Effect of preoperative pulmonary hypertension on outcomes in patients with severe aortic stenosis following surgical aortic valve replacement. The American Journal of Cardiology. 112: 1635-40. PMID 23998349 DOI: 10.1016/j.amjcard.2013.07.025  0.043
2003 Gitelson AA, Verma SB, Vina A, Rundquist DC, Keydan G, Leavitt B, Arkebauer TJ, Burba GG, Suyker AE. Novel technique for remote estimation of CO2 flux in maize Geophysical Research Letters. 30: 39-1. DOI: 10.1029/2002Gl016543  0.042
2009 Rundquist D, Gitelson A, Lawson M, Keydan G, Leavitt B, Perk R, Keck J, Mishra DR, Narumalani S. Proximal sensing of coral features: Spectral characterization of Siderastrea siderea Giscience and Remote Sensing. 46: 139-160. DOI: 10.2747/1548-1603.46.2.139  0.042
2001 Leavitt B. Microbubbles used to ‘pop’ new gene into the heart Clinical Genetics. 58: 269-269. DOI: 10.1034/J.1399-0004.2000.580403.3.X  0.042
2003 Aggarwal A, Leavitt BJ. Images in clinical medicine. Giant Lambl's excrescences. The New England Journal of Medicine. 349: e24. PMID 14681522 DOI: 10.1056/ENEJMicm010900  0.042
1991 LEAVITT B, MAYSINGER D. Lesions of the nucleus basalis magnocellularis of rat by hemicholinium mustard: Protection with monosialoganglioside GM1 Neurochemistry International. 19: 113-123. DOI: 10.1016/0197-0186(91)90126-X  0.041
2006 Lawson M, Leavitt B, Rundquist D, Emanuel N, Perk R, Keck J, Hauschild M. Compensating for irradiance fluxes when measuring the spectral reflectance of corals in Situ Giscience and Remote Sensing. 43: 111-127. DOI: 10.2747/1548-1603.43.2.111  0.041
2002 Fellinger EK, Leavitt BJ, Hebert JC. Serum levels of prophylactic cefazolin during cardiopulmonary bypass surgery. The Annals of Thoracic Surgery. 74: 1187-90. PMID 12400766  0.041
1994 Camp PC, Rogers FB, Shackford SR, Leavitt BJ, Cobean RA, Clark DE. Blunt traumatic thoracic aortic lacerations in the elderly: an analysis of outcome. The Journal of Trauma. 37: 418-23; discussion 4. PMID 8083903  0.041
1993 Mulieri LA, Leavitt BJ, Martin BJ, Haeberle JR, Alpert NR. Myocardial force-frequency defect in mitral regurgitation heart failure is reversed by forskolin. Circulation. 88: 2700-4. PMID 8252681  0.04
1992 Mulieri LA, Hasenfuss G, Leavitt B, Allen PD, Alpert NR. Altered myocardial force-frequency relation in human heart failure. Circulation. 85: 1743-50. PMID 1572031  0.04
2012 Leavitt BD, Van Ess JM. Rapid, early-onset group a streptococcus infection after impacted third molar removal: a review and case series. Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons. 70: 2742-7. PMID 23010371 DOI: 10.1016/j.joms.2012.07.045  0.04
2005 Fukagawa NK, Palmer BM, Barnes WD, Leavitt BJ, Ittleman FP, Lewinter MM, Maughan DW. Acto-myosin crossbridge kinetics in humans with coronary artery disease: influence of sex and diabetes mellitus. Journal of Molecular and Cellular Cardiology. 39: 743-53. PMID 16171812 DOI: 10.1016/j.yjmcc.2005.06.010  0.039
2005 Dall'Olmo G, Gitelson AA, Rundquist DC, Leavitt B, Barrow T, Holz JC. Assessing the potential of SeaWiFS and MODIS for estimating chlorophyll concentration in turbid productive waters using red and near-infrared bands Remote Sensing of Environment. 96: 176-187. DOI: 10.1016/J.Rse.2005.02.007  0.039
2020 Kulkarni JA, Thomson SB, Zaifman J, Leung J, Wagner PK, Hill A, Tam YYC, Cullis PR, Petkau TL, Leavitt BR. Spontaneous, solvent-free entrapment of siRNA within lipid nanoparticles. Nanoscale. PMID 33241838 DOI: 10.1039/d0nr06816k  0.038
2007 Danehy T, Beam R, Horrell S, Dolence R, Ankrom J, Leavitt B, Fuchs W, Busler S, Denholm C, Dunn MH. Nickle Plate abandoned mine pool "blowout" Washington and Allegheny counties, Pennsylvania American Society of Mining and Reclamation - 24th National Meetings of the American Society of Mining and Reclamation 2007: 30 Years of Smcra and Beyond. 2: 529-545.  0.038
1998 Birkmeyer NJ, Charlesworth DC, Hernandez F, Leavitt BJ, Marrin CA, Morton JR, Olmstead EM, O'Connor GT. Obesity and risk of adverse outcomes associated with coronary artery bypass surgery. Northern New England Cardiovascular Disease Study Group. Circulation. 97: 1689-94. PMID 9591762 DOI: 10.1161/01.CIR.97.17.1689  0.038
2010 Hünlich M, Tremble SM, Begin KJ, Leavitt BJ, Ittleman FP, VanBuren P. Atrial contractile protein content and function are preserved in patients with coronary artery disease and atrial fibrillation. Coronary Artery Disease. 21: 357-62. PMID 20657267 DOI: 10.1097/MCA.0b013e32833d5fc9  0.037
2000 Birkmeyer NJ, Marrin CA, Morton JR, Leavitt BJ, Lahey SJ, Charlesworth DC, Hernandez F, Olmstead EM, O'Connor GT. Decreasing mortality for aortic and mitral valve surgery in Northern New England. Northern New England Cardiovascular Disease Study Group. The Annals of Thoracic Surgery. 70: 432-7. PMID 10969658 DOI: 10.1016/S0003-4975(00)01456-9  0.037
2003 Gitelson AA, Vina A, Arkebauer TJ, Rundquist DC, Keydan G, Leavitt B. Remote estimation of leaf area index and green leaf biomass in maize canopies Geophysical Research Letters. 30: 52-1. DOI: 10.1029/2002Gl016450  0.037
2003 Likosky DS, Leavitt BJ, Marrin CA, Malenka DJ, Reeves AG, Weintraub RM, Caplan LR, Baribeau YR, Charlesworth DC, Ross CS, Braxton JH, Hernandez F, O'Connor GT. Intra- and postoperative predictors of stroke after coronary artery bypass grafting. The Annals of Thoracic Surgery. 76: 428-34; discussion 4. PMID 12902078 DOI: 10.1016/S0003-4975(03)00490-9  0.037
1994 Hasenfuss G, Mulieri LA, Leavitt BJ, Alpert NR. Influence of isoproterenol on contractile protein function, excitation-contraction coupling, and energy turnover of isolated nonfailing human myocardium. Journal of Molecular and Cellular Cardiology. 26: 1461-9. PMID 7897670 DOI: 10.1006/jmcc.1994.1165  0.037
1995 Ricci MA, Cloutier LM, Mount S, Welander C, Leavitt BJ. Intravenous leiomyomatosis with intracardiac extension. Cardiovascular Surgery (London, England). 3: 693-6. PMID 8745195  0.036
2014 Chaisson K, Sanford M, Boss RA, Leavitt BJ, Hearne MJ, Ross CS, Olmstead EM, Kramer RS, Hofmaster P, Mingo C, Duquette D, Maislen E, Clark JA, Likosky DS, Horton SR, et al. Improving patients' readiness for coronary artery bypass graft surgery. Critical Care Nurse. 34: 29-36. PMID 25452407 DOI: 10.4037/ccn2014951  0.033
1994 Higgins JC, Katzman PJ, Yeager SB, Dickerman JD, Leavitt BJ, Tischler MD, Battle RW. Extraskeletal Ewing's sarcoma of primary cardiac origin. Pediatric Cardiology. 15: 207-8. PMID 7991441  0.033
2008 Privette A, Fisk P, Leavitt B, Cooper K, McCahill L. Inflammatory myofibroblastic tumor presenting with esophageal obstruction and an inflammatory syndrome. The Annals of Thoracic Surgery. 86: 1364-7. PMID 18805200 DOI: 10.1016/j.athoracsur.2008.03.056  0.031
2004 Leavitt BJ. The effect of not using an internal mammary artery as a conduit for coronary artery bypass grafting. Heart (British Cardiac Society). 90: 1377-8. PMID 15547006 DOI: 10.1136/hrt.2003.027383  0.03
2021 Kulkarni JA, Witzigmann D, Thomson SB, Chen S, Leavitt BR, Cullis PR, van der Meel R. Author Correction: The current landscape of nucleic acid therapeutics. Nature Nanotechnology. PMID 34194013 DOI: 10.1038/s41565-021-00937-w  0.03
2005 Leavitt BR, Stiles J, Donovan JJ, Ziemkiewicz P, Duffy B, Vandivort T. Strategies for cooling electric generating facilities utilizing mine water: Technical and economic feasibility project 22nd Annual International Pittsburgh Coal Conference 2005, Pcc 2005. 2: 1083-1100.  0.029
2011 Page BJ, Leavitt BR, Danehy TP, Leavitt G, Denholm CF, Busler SL, Popeck LB, Dunn MH. Results from the initial "ELF" inter-mine POOL transfer tests 28th Annual Meeting of the American Society of Mining and Reclamation 2011. 519-538.  0.028
2004 Rundquist D, Perk R, Leavitt B, Keydan G, Gitelson A. Collecting spectral data over cropland vegetation using machine-positioning versus hand-positioning of the sensor Computers and Electronics in Agriculture. 43: 173-178. DOI: 10.1016/J.Compag.2003.11.002  0.027
2011 Yacobi YZ, Moses WJ, Kaganovsky S, Sulimani B, Leavitt BC, Gitelson AA. NIR-red reflectance-based algorithms for chlorophyll-a estimation in mesotrophic inland and coastal waters: Lake Kinneret case study. Water Research. 45: 2428-36. PMID 21376361 DOI: 10.1016/J.Watres.2011.02.002  0.026
2018 Thompson L, Leavitt BR. Editorial on Clinical Trial's Corner. Journal of Huntington's Disease. 7: 87. PMID 29504545 DOI: 10.3233/JHD-189000  0.026
2012 Moses WJ, Gitelson AA, Perk RL, Gurlin D, Rundquist DC, Leavitt BC, Barrow TM, Brakhage P. Estimation of chlorophyll-a concentration in turbid productive waters using airborne hyperspectral data. Water Research. 46: 993-1004. PMID 22209281 DOI: 10.1016/J.Watres.2011.11.068  0.026
2013 Goldberg JB, DeSimone JP, Kramer RS, Discipio AW, Russo L, Dacey LJ, Leavitt BJ, Helm RE, Baribeau YR, Sardella G, Clough RA, Surgenor SD, Sorensen MJ, Ross CS, Olmstead EM, et al. Impact of preoperative left ventricular ejection fraction on long-term survival after aortic valve replacement for aortic stenosis. Circulation. Cardiovascular Quality and Outcomes. 6: 35-41. PMID 23300268 DOI: 10.1161/CIRCOUTCOMES.112.965772  0.026
2006 McCoy KJ, Donovan JJ, Leavitt BR. Horizontal hydraulic conductivity estimates for intact coal barriers between closed underground mines Environmental and Engineering Geoscience. 12: 273-282. DOI: 10.2113/gseegeosci.12.3.273  0.025
2009 Leavitt BD, Teeples TJ, Viozzi CF. Submandibular space swelling in a patient with fibrodysplasia ossificans progressiva: a diagnostic dilemma. Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons. 67: 668-73. PMID 19231799 DOI: 10.1016/j.joms.2008.07.011  0.025
2010 Roberts S, Chittapragada M, Pendem K, Leavitt BJ, Mahler JW, Ham YW. Synthesis of 2,4,5-triaminocyclohexanecarboxylic acid as a novel 2-deoxystreptamine mimic Tetrahedron Letters. 51: 1779-1781. DOI: 10.1016/j.tetlet.2010.01.111  0.024
2007 Leavitt BG, Huff DL, Bell LA, Thurnau GR. Placental drainage of fetal blood at cesarean delivery and feto maternal transfusion: a randomized controlled trial. Obstetrics and Gynecology. 110: 608-11. PMID 17766607 DOI: 10.1097/01.AOG.0000277262.80793.0d  0.021
2004 Lehot JJ, Leavitt BJ, Fellinger EK, Hebert JC. Cefazolin prophylaxis during cardiac operations [3] (multiple letters) Annals of Thoracic Surgery. 77: 755-756. PMID 14759489 DOI: 10.1016/S0003-4975(03)01429-2  0.019
1996 Blondin J, Schriefer J, Shinozaki T, Calhoun B, Leavitt B, Deane R, LaChaunce W. The Quality Cup winner: Fletcher Allen Health Care's early extubation team. Quality Management in Health Care. 4: 42-54. PMID 10154536  0.018
1992 Mulieri LA, Leavitt BJ, Hasenfuss G, Allen PD, Alpert NR. Contraction frequency dependence of twitch and diastolic tension in human dilated cardiomyopathy (tension-frequency relation in cardiomyopathy). Basic Research in Cardiology. 87: 199-212. PMID 1497569  0.017
1992 Blanchard EM, Leavitt BJ, Mulieri LA, Alpert NR. Dynamic calcium requirements for activation of human ventricular muscle calculated from tension-independent heat. Basic Research in Cardiology. 87: 245-53. PMID 1497572  0.017
2017 Leavitt BR, Thompson LM. Introducing the "Clinical Trials Corner". Journal of Huntington's Disease. 6: 167. PMID 28968246 DOI: 10.3233/JHD-179003  0.017
1996 Rogers FB, Leavitt BJ, Jensen PE. Traumatic transdiaphragmatic intercostal hernia secondary to coughing: case report and review of the literature. The Journal of Trauma. 41: 902-3. PMID 8913225  0.016
2014 Fillmore WJ, Leavitt BD, Arce K. Dental extraction in the neutropenic patient. Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons. 72: 2386-93. PMID 25218884 DOI: 10.1016/j.joms.2014.06.443  0.016
1953 LEAVITT B. Miscarriage caused by unsuspected pelvic tuberculosis; report of a case. The Journal of the International College of Surgeons. 20: 200-3. PMID 13084962  0.015
2006 Ganatra K, Riesenfeld E, Singh N, Fought J, Weiss D, Leavitt B. A case of progressive dyspnea and pleuritic chest pain Journal of Respiratory Diseases. 27: 433-434.  0.013
2010 Leavitt BR. In situ iron oxidation using hydrogen peroxide Joint Mining Reclamation Conf. 2010 - 27th Meeting of the Asmr, 12th Pennsylvania Abandoned Mine Reclamation Conf. and 4th Appalachian Regional Reforestation Initiative Mined Land Reforestation Conf.. 1: 551-569.  0.012
2013 Fillmore WJ, Leavitt BD, Arce K. Dental extraction in the thrombocytopenic patient is safe and complications are easily managed. Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons. 71: 1647-52. PMID 23932116 DOI: 10.1016/j.joms.2013.05.011  0.01
2011 Meisinger QC, Klein JS, Butnor KJ, Gentchos G, Leavitt BJ. CT features of peripheral pulmonary carcinoid tumors. Ajr. American Journal of Roentgenology. 197: 1073-80. PMID 22021498 DOI: 10.2214/AJR.10.5954  0.01
2021 Leavitt BR, Thompson LM. Editorial. Journal of Huntington's Disease. PMID 33554922 DOI: 10.3233/JHD-219002  0.01
2014 Leavitt BJ. Invited commentary on "new TNM staging system for esophageal cancer". Radiographics : a Review Publication of the Radiological Society of North America, Inc. 34: 1740-1. PMID 25310427 DOI: 10.1148/rg.346140237  0.01
2013 Leavitt BJ. Out of bed with a good COUGH, just what the doctor ordered. Jama Surgery. 148: 745-6. PMID 23740363 DOI: 10.1001/jamasurg.2013.375  0.01
2013 Hirashima F, Leavitt BJ. Invited commentary. The Annals of Thoracic Surgery. 95: 531-2. PMID 23336868 DOI: 10.1016/j.athoracsur.2012.09.002  0.01
2010 Surgenor SD, Marrin CAS, Leavitt BJ, Morton JR, Kramer RS, Olmstead EM, Ross CS, Charlesworth DC, Clough RA, Hernandez F, Selke FW, Likosky DS, Helm RE, O'Connor GT. In response Anesthesia and Analgesia. 110: 972. DOI: 10.1213/ANE.0b013e3181ca4c6d  0.01
2009 Hayden MR, Leavitt BR, Yasothan U, Kirkpatrick P. Tetrabenazine. Nature Reviews. Drug Discovery. 8: 17-8. PMID 19116624 DOI: 10.1038/nrd2784  0.01
2006 Gitelson AA, Viña A, Verma SB, Rundquist DC, Arkebauer TJ, Keydan G, Leavitt B, Ciganda V, Burba GG, Suyker AE. Relationship between gross primary production and chlorophyll content in crops: Implications for the synoptic monitoring of vegetation productivity Journal of Geophysical Research Atmospheres. 111. DOI: 10.1029/2005Jd006017  0.01
2001 Chamberlin MD, Eltabbakh GH, Mount SL, Leavitt BJ. Metastatic serous borderline ovarian tumor in an internal mammary lymph node: a case report and review of the literature. Gynecologic Oncology. 82: 212-5. PMID 11426990 DOI: 10.1006/gyno.2001.6234  0.01
2001 Leavitt B. Repairing the genomic defect in muscular dystrophy Clinical Genetics. 58: 265-266. DOI: 10.1034/j.1399-0004.2000.580403.1.x  0.01
1999 Leavitt B. HotSpots Clinical Genetics. 55: 226-230. DOI: 10.1034/j.1399-0004.1999.550402.x  0.01
1992 Tischler MD, Cooper KA, Battle RW, Leavitt BJ. Effect of mitral valve repair for mitral valve prolapse on regression of left ventricular mass. The American Journal of Cardiology. 70: 1216-7. PMID 1414951 DOI: 10.1016/0002-9149(92)90061-3  0.01
1991 Crews JC, Hilgenhurst G, Leavitt B, Denson DD, Bridenbaugh PO, Stuebing RC. Tourniquet pain: the response to the maintenance of tourniquet inflation on the upper extremity of volunteers. Regional Anesthesia. 16: 314-7. PMID 1772813  0.01
1988 Walker MJ, Leavitt B, Mucha RF. Saccharin exposure increases the potency and aversive property of naloxone in drug-naive rats. Life Sciences. 43: 1305-11. PMID 3172982  0.01
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