Schahram Akbarian - Publications

Affiliations: 
Mount Sinai School of Medicine, New York, NY 
Area:
epigenetics
Website:
https://labs.neuroscience.mssm.edu/akbarian-lab/

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Year Citation  Score
2024 Wahl N, Espeso-Gil S, Chietera P, Nagel A, Laighneach A, Morris DW, Rajarajan P, Akbarian S, Dechant G, Apostolova G. SATB2 organizes the 3D genome architecture of cognition in cortical neurons. Molecular Cell. PMID 38244545 DOI: 10.1016/j.molcel.2023.12.024  0.424
2023 Tandon R, Nasrallah H, Akbarian S, Carpenter WT, DeLisi LE, Gaebel W, Green MF, Gur RE, Heckers S, Kane JM, Malaspina D, Meyer-Lindenberg A, Murray R, Owen M, Smoller JW, et al. The schizophrenia syndrome, circa 2024: What we know and how that informs its nature. Schizophrenia Research. 264: 1-28. PMID 38086109 DOI: 10.1016/j.schres.2023.11.015  0.361
2023 Garrison MA, Jang Y, Bae T, Cherskov A, Emery SB, Fasching L, Jones A, Moldovan JB, Molitor C, Pochareddy S, Peters MA, Shin JH, Wang Y, Yang X, Akbarian S, et al. Genomic data resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases. Scientific Data. 10: 813. PMID 37985666 DOI: 10.1038/s41597-023-02645-7  0.346
2023 Wei J, Lambert TY, Valada A, Patel N, Walker K, Lenders J, Schmidt CJ, Iskhakova M, Alazizi A, Mair-Meijers H, Mash DC, Luca F, Pique-Regi R, Bannon MJ, Akbarian S. Single nucleus transcriptomics of ventral midbrain identifies glial activation associated with chronic opioid use disorder. Nature Communications. 14: 5610. PMID 37699936 DOI: 10.1038/s41467-023-41455-8  0.319
2023 Maury EA, Sherman MA, Genovese G, Gilgenast TG, Kamath T, Burris SJ, Rajarajan P, Flaherty E, Akbarian S, Chess A, McCarroll SA, Loh PR, Phillips-Cremins JE, Brennand KJ, Macosko EZ, et al. Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrent and disruptions. Cell Genomics. 3: 100356. PMID 37601975 DOI: 10.1016/j.xgen.2023.100356  0.328
2023 Powell SK, Liao W, O'Shea C, Kammourh S, Ghorbani S, Rigat R, Elahi R, Deans PM, Le DJ, Agarwal P, Seow WQ, Wang KC, Akbarian S, Brennand KJ. Schizophrenia Risk Mapping and Functional Engineering of the 3D Genome in Three Neuronal Subtypes. Biorxiv : the Preprint Server For Biology. PMID 37502907 DOI: 10.1101/2023.07.17.549339  0.419
2022 Plaza-Jennings A, Valada A, Akbarian S. 3D Genome Plasticity in Normal and Diseased Neurodevelopment. Genes. 13. PMID 36360237 DOI: 10.3390/genes13111999  0.369
2022 Girdhar K, Hoffman GE, Bendl J, Rahman S, Dong P, Liao W, Hauberg ME, Sloofman L, Brown L, Devillers O, Kassim BS, Wiseman JR, Park R, Zharovsky E, Jacobov R, ... ... Akbarian S, et al. Chromatin domain alterations linked to 3D genome organization in a large cohort of schizophrenia and bipolar disorder brains. Nature Neuroscience. PMID 35332326 DOI: 10.1038/s41593-022-01032-6  0.734
2022 Rapanelli M, Williams JB, Ma K, Yang F, Zhong P, Patel R, Kumar M, Qin L, Rein B, Wang ZJ, Kassim B, Javidfar B, Couto L, Akbarian S, Yan Z. Targeting histone demethylase LSD1 for treatment of deficits in autism mouse models. Molecular Psychiatry. PMID 35296809 DOI: 10.1038/s41380-022-01508-8  0.368
2021 Chandrasekaran S, Espeso-Gil S, Loh YE, Javidfar B, Kassim B, Zhu Y, Zhang Y, Dong Y, Bicks LK, Li H, Rajarajan P, Peter CJ, Sun D, Agullo-Pascual E, Iskhakova M, ... ... Akbarian S, et al. Neuron-specific chromosomal megadomain organization is adaptive to recent retrotransposon expansions. Nature Communications. 12: 7243. PMID 34903713 DOI: 10.1038/s41467-021-26862-z  0.3
2021 Dobrindt K, Zhang H, Das D, Abdollahi S, Prorok T, Ghosh S, Weintraub S, Genovese G, Powell SK, Lund A, Akbarian S, Eggan K, McCarroll S, Duan J, Avramopoulos D, et al. Publicly Available hiPSC Lines with Extreme Polygenic Risk Scores for Modeling Schizophrenia. Complex Psychiatry. 6: 68-82. PMID 34883504 DOI: 10.1159/000512716  0.352
2021 Powell SK, O'Shea C, Townsley K, Prytkova I, Dobrindt K, Elahi R, Iskhakova M, Lambert T, Valada A, Liao W, Ho SM, Slesinger PA, Huckins LM, Akbarian S, Brennand KJ. Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease risk. Molecular Psychiatry. PMID 34493831 DOI: 10.1038/s41380-021-01273-0  0.337
2021 Hu B, Won H, Mah W, Park RB, Kassim B, Spiess K, Kozlenkov A, Crowley CA, Pochareddy S, Li Y, Dracheva S, Sestan N, Akbarian S, Geschwind DH. Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders. Nature Communications. 12: 3968. PMID 34172755 DOI: 10.1038/s41467-021-24243-0  0.451
2021 Espeso-Gil S, Holik AZ, Bonnin S, Jhanwar S, Chandrasekaran S, Pique-Regi R, Albaigès-Ràfols J, Maher M, Permanyer J, Irimia M, Friedländer MR, Pons-Espinal M, Akbarian S, Dierssen M, Maass PG, et al. Environmental Enrichment Induces Epigenomic and Genome Organization Changes Relevant for Cognition. Frontiers in Molecular Neuroscience. 14: 664912. PMID 34025350 DOI: 10.3389/fnmol.2021.664912  0.346
2020 Powell SK, O'Shea C, Brennand KJ, Akbarian S. Parsing the Functional Impact of Noncoding Genetic Variants in the Brain Epigenome. Biological Psychiatry. PMID 33131715 DOI: 10.1016/j.biopsych.2020.06.033  0.661
2020 Dobrindt K, Hoagland DA, Seah C, Kassim B, O'Shea CP, Iskhakova M, Fernando MB, Deans PJM, Powell SK, Javidfar B, Murphy A, Peter C, Møeller R, Garcia MF, Kimura M, ... ... Akbarian S, et al. Common genetic variation in humans impacts susceptibility to SARS-CoV-2 infection. Biorxiv : the Preprint Server For Biology. PMID 32995783 DOI: 10.1101/2020.09.20.300574  0.545
2020 Powell SK, O'Shea CP, Shannon SR, Akbarian S, Brennand KJ. Investigation of Schizophrenia with Human Induced Pluripotent Stem Cells. Advances in Neurobiology. 25: 155-206. PMID 32578147 DOI: 10.1007/978-3-030-45493-7_6  0.643
2020 Sey NYA, Hu B, Mah W, Fauni H, McAfee JC, Rajarajan P, Brennand KJ, Akbarian S, Won H. A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles. Nature Neuroscience. PMID 32152537 DOI: 10.1038/S41593-020-0603-0  0.652
2020 Espeso-Gil S, Halene T, Bendl J, Kassim B, Ben Hutta G, Iskhakova M, Shokrian N, Auluck P, Javidfar B, Rajarajan P, Chandrasekaran S, Peter CJ, Cote A, Birnbaum R, Liao W, ... ... Akbarian S, et al. A chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons. Genome Medicine. 12: 19. PMID 32075678 DOI: 10.1186/S13073-020-0715-X  0.33
2019 Rajarajan P, Akbarian S. Use of the epigenetic toolbox
to contextualize common variants associated with schizophrenia risk
. Dialogues in Clinical Neuroscience. 21: 407-416. PMID 31949408 DOI: 10.31887/Dcns.2019.21.4/Sakbarian  0.426
2019 Gusev FE, Reshetov DA, Mitchell AC, Andreeva TV, Dincer A, Grigorenko AP, Fedonin G, Halene T, Aliseychik M, Filippova E, Weng Z, Akbarian S, Rogaev EI. Chromatin profiling of cortical neurons identifies individual epigenetic signatures in schizophrenia. Translational Psychiatry. 9: 256. PMID 31624234 DOI: 10.1038/S41398-019-0596-1  0.738
2019 Hoffman GE, Bendl J, Voloudakis G, Montgomery KS, Sloofman L, Wang YC, Shah HR, Hauberg ME, Johnson JS, Girdhar K, Song L, Fullard JF, Kramer R, Hahn CG, Gur R, ... ... Akbarian S, et al. CommonMind Consortium provides transcriptomic and epigenomic data for Schizophrenia and Bipolar Disorder. Scientific Data. 6: 180. PMID 31551426 DOI: 10.1038/S41597-019-0183-6  0.392
2019 Peter CJ, Saito A, Hasegawa Y, Tanaka Y, Nagpal M, Perez G, Alway E, Espeso-Gil S, Fayyad T, Ratner C, Dincer A, Gupta A, Devi L, Pappas JG, Lalonde FM, ... ... Akbarian S, et al. In vivo epigenetic editing of Sema6a promoter reverses transcallosal dysconnectivity caused by C11orf46/Arl14ep risk gene. Nature Communications. 10: 4112. PMID 31511512 DOI: 10.1038/S41467-019-12013-Y  0.385
2019 Rajarajan P, Flaherty E, Akbarian S, Brennand KJ. CRISPR-based functional evaluation of schizophrenia risk variants. Schizophrenia Research. PMID 31277978 DOI: 10.1016/J.Schres.2019.06.017  0.656
2019 Rajarajan P, Borrman T, Liao W, Espeso-Gil S, Chandrasekaran S, Jiang Y, Weng Z, Brennand KJ, Akbarian S. Spatial genome exploration in the context of cognitive and neurological disease. Current Opinion in Neurobiology. 59: 112-119. PMID 31255842 DOI: 10.1016/J.Conb.2019.05.007  0.655
2019 Gusev FE, Reshetov DA, Mitchell AC, Andreeva TV, Dincer A, Grigorenko AP, Fedonin G, Halene T, Aliseychik M, Goltsov AY, Solovyev V, Brizgalov L, Filippova E, Weng Z, Akbarian S, et al. Epigenetic-genetic chromatin footprinting identifies novel and subject-specific genes active in prefrontal cortex neurons. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201802646R. PMID 30970224 DOI: 10.1096/Fj.201802646R  0.717
2018 Wang D, Liu S, Warrell J, Won H, Shi X, Navarro FCP, Clarke D, Gu M, Emani P, Yang YT, Xu M, Gandal MJ, Lou S, Zhang J, Park JJ, ... ... Akbarian S, et al. Comprehensive functional genomic resource and integrative model for the human brain. Science (New York, N.Y.). 362. PMID 30545857 DOI: 10.1126/Science.Aat8464  0.411
2018 Rajarajan P, Borrman T, Liao W, Schrode N, Flaherty E, Casiño C, Powell S, Yashaswini C, LaMarca EA, Kassim B, Javidfar B, Espeso-Gil S, Li A, Won H, Geschwind DH, ... ... Akbarian S, et al. Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk. Science (New York, N.Y.). 362. PMID 30545851 DOI: 10.1126/Science.Aat4311  0.685
2018 Bryois J, Garrett ME, Song L, Safi A, Giusti-Rodriguez P, Johnson GD, Shieh AW, Buil A, Fullard JF, Roussos P, Sklar P, Akbarian S, Haroutunian V, Stockmeier CA, Wray GA, et al. Evaluation of chromatin accessibility in prefrontal cortex of individuals with schizophrenia. Nature Communications. 9: 3121. PMID 30087329 DOI: 10.1038/S41467-018-05379-Y  0.423
2018 Girdhar K, Hoffman GE, Jiang Y, Brown L, Kundakovic M, Hauberg ME, Francoeur NJ, Wang YC, Shah H, Kavanagh DH, Zharovsky E, Jacobov R, Wiseman JR, Park R, Johnson JS, ... ... Akbarian S, et al. Cell-specific histone modification maps in the human frontal lobe link schizophrenia risk to the neuronal epigenome. Nature Neuroscience. PMID 30038276 DOI: 10.1038/S41593-018-0187-0  0.738
2018 Rajarajan P, Jiang Y, Kassim BS, Akbarian S. Chromosomal Conformations and Epigenomic Regulation in Schizophrenia. Progress in Molecular Biology and Translational Science. 157: 21-40. PMID 29933951 DOI: 10.1016/Bs.Pmbts.2017.11.022  0.49
2018 Mao W, Salzberg AC, Uchigashima M, Hasegawa Y, Hock H, Watanabe M, Akbarian S, Kawasawa YI, Futai K. Activity-Induced Regulation of Synaptic Strength through the Chromatin Reader L3mbtl1. Cell Reports. 23: 3209-3222. PMID 29898393 DOI: 10.1016/J.Celrep.2018.05.028  0.318
2018 Dobbyn A, Huckins LM, Boocock J, Sloofman LG, Glicksberg BS, Giambartolomei C, Hoffman GE, Perumal TM, Girdhar K, Jiang Y, Raj T, Ruderfer DM, Kramer RS, Pinto D, ... Akbarian S, et al. Landscape of Conditional eQTL in Dorsolateral Prefrontal Cortex and Co-localization with Schizophrenia GWAS. American Journal of Human Genetics. PMID 29805045 DOI: 10.1016/J.Ajhg.2018.04.011  0.367
2018 LaMarca EA, Powell SK, Akbarian S, Brennand KJ. Modeling Neuropsychiatric and Neurodegenerative Diseases With Induced Pluripotent Stem Cells. Frontiers in Pediatrics. 6: 82. PMID 29666786 DOI: 10.3389/Fped.2018.00082  0.576
2017 Ibi D, de la Fuente Revenga M, Kezunovic N, Muguruza C, Saunders JM, Gaitonde SA, Moreno JL, Ijaz MK, Santosh V, Kozlenkov A, Holloway T, Seto J, García-Bea A, Kurita M, Mosley GE, ... ... Akbarian S, et al. Antipsychotic-induced Hdac2 transcription via NF-κB leads to synaptic and cognitive side effects. Nature Neuroscience. PMID 28783139 DOI: 10.1038/Nn.4616  0.307
2017 Ho SM, Hartley BJ, Flaherty E, Rajarajan P, Abdelaal R, Obiorah I, Barretto N, Muhammad H, Phatnani HP, Akbarian S, Brennand KJ. Evaluating Synthetic Activation and Repression of Neuropsychiatric-Related Genes in hiPSC-Derived NPCs, Neurons, and Astrocytes. Stem Cell Reports. PMID 28757163 DOI: 10.1016/J.Stemcr.2017.06.012  0.632
2017 Javidfar B, Park R, Kassim BS, Bicks LK, Akbarian S. The epigenomics of schizophrenia, in the mouse. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. PMID 28699694 DOI: 10.1002/ajmg.b.32566  0.47
2017 Jiang Y, Loh YE, Rajarajan P, Hirayama T, Liao W, Kassim BS, Javidfar B, Hartley BJ, Kleofas L, Park RB, Labonte B, Ho SM, Chandrasekaran S, Do C, Ramirez BR, ... ... Akbarian S, et al. The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain. Nature Genetics. PMID 28671686 DOI: 10.1038/Ng.3906  0.674
2017 Engmann O, Labonté B, Mitchell A, Bashtrykov P, Calipari ES, Rosenbluh C, Loh YE, Walker DM, Burek D, Hamilton PJ, Issler O, Neve RL, Turecki G, Hurd Y, Chess A, ... ... Akbarian S, et al. Cocaine-Induced Chromatin Modifications Associate With Increased Expression and Three-Dimensional Looping of Auts2. Biological Psychiatry. PMID 28577753 DOI: 10.1016/J.Biopsych.2017.04.013  0.652
2017 McConnell MJ, Moran JV, Abyzov A, Akbarian S, Bae T, Cortes-Ciriano I, Erwin JA, Fasching L, Flasch DA, Freed D, Ganz J, Jaffe AE, Kwan KY, Kwon M, Lodato MA, et al. Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network. Science (New York, N.Y.). 356. PMID 28450582 DOI: 10.1126/Science.Aal1641  0.383
2016 Rajarajan P, Gil SE, Brennand KJ, Akbarian S. Spatial genome organization and cognition. Nature Reviews. Neuroscience. PMID 27708356 DOI: 10.1038/Nrn.2016.124  0.623
2016 Liu X, Han D, Somel M, Jiang X, Hu H, Guijarro P, Zhang N, Mitchell A, Halene T, Ely JJ, Sherwood CC, Hof PR, Qiu Z, Pääbo S, Akbarian S, et al. Disruption of an Evolutionarily Novel Synaptic Expression Pattern in Autism. Plos Biology. 14: e1002558. PMID 27685936 DOI: 10.1371/Journal.Pbio.1002558  0.671
2016 Mitchell AC, Javidfar B, Bicks LK, Neve R, Garbett K, Lander SS, Mirnics K, Morishita H, Wood MA, Jiang Y, Gaisler-Salomon I, Akbarian S. Longitudinal assessment of neuronal 3D genomes in mouse prefrontal cortex. Nature Communications. 7: 12743. PMID 27597321 DOI: 10.1038/Ncomms12743  0.702
2016 Shen EY, Jiang Y, Javidfar B, Kassim B, Loh YH, Ma Q, Mitchell AC, Pothula V, Stewart AF, Ernst P, Yao WD, Martin G, Shen L, Jakovcevski M, Akbarian S. Neuronal Deletion of Kmt2a/Mll1 Histone Methyltransferase in Ventral Striatum is Associated with Defective Spike-Timing Dependent Striatal Synaptic Plasticity, Altered Response to Dopaminergic Drugs and Increased Anxiety. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27485686 DOI: 10.1038/Npp.2016.144  0.689
2016 Peter CJ, Fischer LK, Kundakovic M, Garg P, Jakovcevski M, Dincer A, Amaral AC, Ginns EI, Galdzicka M, Bryce CP, Ratner C, Waber DP, Mokler D, Medford G, Champagne FA, ... ... Akbarian S, et al. DNA Methylation Signatures of Early Childhood Malnutrition Associated With Impairments in Attention and Cognition. Biological Psychiatry. PMID 27184921 DOI: 10.1016/J.Biopsych.2016.03.2100  0.704
2016 Kundakovic M, Jiang Y, Kavanagh DH, Dincer A, Brown L, Pothula V, Zharovsky E, Park R, Jacobov R, Magro I, Kassim B, Wiseman J, Dang K, Sieberts SK, Roussos P, ... ... Akbarian S, et al. Practical Guidelines for High-Resolution Epigenomic Profiling of Nucleosomal Histones in Postmortem Human Brain Tissue. Biological Psychiatry. PMID 27113501 DOI: 10.1016/J.Biopsych.2016.03.1048  0.724
2016 Fullard JF, Halene TB, Giambartolomei C, Haroutunian V, Akbarian S, Roussos P. Understanding the genetic liability to schizophrenia through the neuroepigenome. Schizophrenia Research. PMID 26827128 DOI: 10.1016/J.Schres.2016.01.039  0.43
2016 Halene TB, Kozlenkov A, Jiang Y, Mitchell AC, Javidfar B, Dincer A, Park R, Wiseman J, Croxson PL, Giannaris EL, Hof PR, Roussos P, Dracheva S, Hemby SE, Akbarian S. NeuN(+) neuronal nuclei in non-human primate prefrontal cortex and subcortical white matter after clozapine exposure. Schizophrenia Research. PMID 26776227 DOI: 10.1016/J.Schres.2015.12.016  0.668
2015 Labadorf A, Hoss AG, Lagomarsino V, Latourelle JC, Hadzi TC, Bregu J, MacDonald ME, Gusella JF, Chen JF, Akbarian S, Weng Z, Myers RH. RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression. Plos One. 10: e0143563. PMID 26636579 DOI: 10.1371/Journal.Pone.0143563  0.362
2015 Dong X, Tsuji J, Labadorf A, Roussos P, Chen JF, Myers RH, Akbarian S, Weng Z. The Role of H3K4me3 in Transcriptional Regulation Is Altered in Huntington's Disease. Plos One. 10: e0144398. PMID 26636336 DOI: 10.1371/Journal.Pone.0144398  0.37
2015 Akbarian S, Liu C, Knowles JA, Vaccarino FM, Farnham PJ, Crawford GE, Jaffe AE, Pinto D, Dracheva S, Geschwind DH, Mill J, Nairn AC, Abyzov A, Pochareddy S, Prabhakar S, et al. The PsychENCODE project. Nature Neuroscience. 18: 1707-1712. PMID 26605881 DOI: 10.1038/Nn.4156  0.737
2015 Akbarian S, Kundakovic M. CHRNA7 and CHRFAM7A: Psychosis and Smoking? Blame the Neighbors! The American Journal of Psychiatry. 172: 1054-6. PMID 26575444 DOI: 10.1176/Appi.Ajp.2015.15081018  0.745
2015 Jakovcevski M, Akbarian S, Di Benedetto B. Pharmacological modulation of astrocytes and the role of cell type-specific histone modifications for the treatment of mood disorders. Current Opinion in Pharmacology. 26: 61-6. PMID 26515273 DOI: 10.1016/j.coph.2015.10.002  0.343
2015 Nestler EJ, Peña CJ, Kundakovic M, Mitchell A, Akbarian S. Epigenetic Basis of Mental Illness. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. PMID 26450593 DOI: 10.1177/1073858415608147  0.784
2015 Maze I, Wenderski W, Noh KM, Bagot RC, Tzavaras N, Purushothaman I, Elsässer SJ, Guo Y, Ionete C, Hurd YL, Tamminga CA, Halene T, Farrelly L, Soshnev AA, Wen D, ... ... Akbarian S, et al. Critical Role of Histone Turnover in Neuronal Transcription and Plasticity. Neuron. 87: 77-94. PMID 26139371 DOI: 10.1016/J.Neuron.2015.06.014  0.403
2015 Mahajan S, Crisci J, Wong A, Akbarian S, Foll M, Jensen JD. Quantifying polymorphism and divergence from epigenetic data: a framework for inferring the action of selection. Frontiers in Genetics. 6: 190. PMID 26074949 DOI: 10.3389/Fgene.2015.00190  0.361
2015 Shen EY, Jiang Y, Mao W, Futai K, Hock H, Akbarian S. Cognition and mood-related behaviors in L3mbtl1 null mutant mice. Plos One. 10: e0121252. PMID 25849281 DOI: 10.1371/Journal.Pone.0121252  0.327
2015 Morishita H, Kundakovic M, Bicks L, Mitchell A, Akbarian S. Interneuron epigenomes during the critical period of cortical plasticity: Implications for schizophrenia. Neurobiology of Learning and Memory. PMID 25849095 DOI: 10.1016/J.Nlm.2015.03.005  0.803
2015 Jakovcevski M, Ruan H, Shen EY, Dincer A, Javidfar B, Ma Q, Peter CJ, Cheung I, Mitchell AC, Jiang Y, Lin CL, Pothula V, Stewart AF, Ernst P, Yao WD, ... Akbarian S, et al. Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 5097-108. PMID 25834037 DOI: 10.1523/Jneurosci.3004-14.2015  0.69
2015 Hess JL, Quinn TP, Akbarian S, Glatt SJ. Bioinformatic analyses and conceptual synthesis of evidence linking ZNF804A to risk for schizophrenia and bipolar disorder. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 168: 14-35. PMID 25522715 DOI: 10.1002/Ajmg.B.32284  0.396
2015 Bai G, Cheung I, Shulha HP, Coelho JE, Li P, Dong X, Jakovcevski M, Wang Y, Grigorenko A, Jiang Y, Hoss A, Patel K, Zheng M, Rogaev E, Myers RH, ... ... Akbarian S, et al. Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains. Human Molecular Genetics. 24: 1441-56. PMID 25480889 DOI: 10.1093/Hmg/Ddu561  0.432
2015 Akbarian S. Epigenetic mechanisms in schizophrenia. Dialogues in Clinical Neuroscience. 16: 405-17. PMID 25364289  0.483
2015 Shen EY, Ahern TH, Cheung I, Straubhaar J, Dincer A, Houston I, de Vries GJ, Akbarian S, Forger NG. Epigenetics and sex differences in the brain: A genome-wide comparison of histone-3 lysine-4 trimethylation (H3K4me3) in male and female mice. Experimental Neurology. 268: 21-9. PMID 25131640 DOI: 10.1016/J.Expneurol.2014.08.006  0.319
2014 Bharadwaj R, Peter CJ, Jiang Y, Roussos P, Vogel-Ciernia A, Shen EY, Mitchell AC, Mao W, Whittle C, Dincer A, Jakovcevski M, Pothula V, Rasmussen TP, Giakoumaki SG, Bitsios P, ... ... Akbarian S, et al. Conserved higher-order chromatin regulates NMDA receptor gene expression and cognition. Neuron. 84: 997-1008. PMID 25467983 DOI: 10.1016/J.Neuron.2014.10.032  0.688
2014 Mitchell AC, Jiang Y, Peter C, Akbarian S. Transcriptional regulation of GAD1 GABA synthesis gene in the prefrontal cortex of subjects with schizophrenia. Schizophrenia Research. PMID 25458568 DOI: 10.1016/j.schres.2014.10.020  0.732
2014 Roussos P, Mitchell AC, Voloudakis G, Fullard JF, Pothula VM, Tsang J, Stahl EA, Georgakopoulos A, Ruderfer DM, Charney A, Okada Y, Siminovitch KA, Worthington J, Padyukov L, Klareskog L, ... ... Akbarian S, et al. A role for noncoding variation in schizophrenia. Cell Reports. 9: 1417-29. PMID 25453756 DOI: 10.1016/J.Celrep.2014.10.015  0.773
2014 Mitchell A, Roussos P, Peter C, Tsankova N, Akbarian S. The future of neuroepigenetics in the human brain. Progress in Molecular Biology and Translational Science. 128: 199-228. PMID 25410546 DOI: 10.1016/B978-0-12-800977-2.00008-5  0.739
2014 Maze I, Shen L, Zhang B, Garcia BA, Shao N, Mitchell A, Sun H, Akbarian S, Allis CD, Nestler EJ. Analytical tools and current challenges in the modern era of neuroepigenomics. Nature Neuroscience. 17: 1476-90. PMID 25349914 DOI: 10.1038/Nn.3816  0.667
2014 Shen E, Shulha H, Weng Z, Akbarian S. Regulation of histone H3K4 methylation in brain development and disease. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 369. PMID 25135975 DOI: 10.1098/Rstb.2013.0514  0.44
2014 Mitchell AC, Bharadwaj R, Whittle C, Krueger W, Mirnics K, Hurd Y, Rasmussen T, Akbarian S. The genome in three dimensions: a new frontier in human brain research. Biological Psychiatry. 75: 961-9. PMID 23958183 DOI: 10.1016/J.Biopsych.2013.07.015  0.731
2013 Bharadwaj R, Jiang Y, Mao W, Jakovcevski M, Dincer A, Krueger W, Garbett K, Whittle C, Tushir JS, Liu J, Sequeira A, Vawter MP, Gardner PD, Casaccia P, Rasmussen T, ... ... Akbarian S, et al. Conserved chromosome 2q31 conformations are associated with transcriptional regulation of GAD1 GABA synthesis enzyme and altered in prefrontal cortex of subjects with schizophrenia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 11839-51. PMID 23864674 DOI: 10.1523/Jneurosci.1252-13.2013  0.462
2013 Jakovcevski M, Bharadwaj R, Straubhaar J, Gao G, Gavin DP, Jakovcevski I, Mitchell AC, Akbarian S. Prefrontal cortical dysfunction after overexpression of histone deacetylase 1. Biological Psychiatry. 74: 696-705. PMID 23664640 DOI: 10.1016/J.Biopsych.2013.03.020  0.7
2013 Shulha HP, Cheung I, Guo Y, Akbarian S, Weng Z. Coordinated cell type-specific epigenetic remodeling in prefrontal cortex begins before birth and continues into early adulthood. Plos Genetics. 9: e1003433. PMID 23593028 DOI: 10.1371/Journal.Pgen.1003433  0.383
2013 Akbarian S, Beeri MS, Haroutunian V. Epigenetic determinants of healthy and diseased brain aging and cognition. Jama Neurology. 70: 711-8. PMID 23571692 DOI: 10.1001/Jamaneurol.2013.1459  0.306
2013 Hasan A, Mitchell A, Schneider A, Halene T, Akbarian S. Epigenetic dysregulation in schizophrenia: molecular and clinical aspects of histone deacetylase inhibitors. European Archives of Psychiatry and Clinical Neuroscience. 263: 273-84. PMID 23381549 DOI: 10.1007/s00406-013-0395-2  0.684
2013 Akbarian S, Nestler EJ. Epigenetic mechanisms in psychiatry. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 1-2. PMID 23147478 DOI: 10.1038/npp.2012.185  0.46
2013 Houston I, Peter CJ, Mitchell A, Straubhaar J, Rogaev E, Akbarian S. Epigenetics in the human brain. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 183-97. PMID 22643929 DOI: 10.1038/npp.2012.78  0.744
2012 Shulha HP, Crisci JL, Reshetov D, Tushir JS, Cheung I, Bharadwaj R, Chou HJ, Houston IB, Peter CJ, Mitchell AC, Yao WD, Myers RH, Chen JF, Preuss TM, Rogaev EI, ... ... Akbarian S, et al. Human-specific histone methylation signatures at transcription start sites in prefrontal neurons. Plos Biology. 10: e1001427. PMID 23185133 DOI: 10.1371/Journal.Pbio.1001427  0.734
2012 Jakovcevski M, Akbarian S. Epigenetic mechanisms in neurological disease. Nature Medicine. 18: 1194-204. PMID 22869198 DOI: 10.1038/nm.2828  0.337
2012 Connor CM, Dincer A, Straubhaar J, Galler JR, Houston IB, Akbarian S. Maternal immune activation alters behavior in adult offspring, with subtle changes in the cortical transcriptome and epigenome. Schizophrenia Research. 140: 175-84. PMID 22804924 DOI: 10.1016/J.Schres.2012.06.037  0.356
2012 Gavin DP, Akbarian S. Epigenetic and post-transcriptional dysregulation of gene expression in schizophrenia and related disease. Neurobiology of Disease. 46: 255-62. PMID 22182689 DOI: 10.1016/J.Nbd.2011.12.008  0.423
2012 Shulha HP, Cheung I, Whittle C, Wang J, Virgil D, Lin CL, Guo Y, Lessard A, Akbarian S, Weng Z. Epigenetic signatures of autism: trimethylated H3K4 landscapes in prefrontal neurons. Archives of General Psychiatry. 69: 314-24. PMID 22065254 DOI: 10.1001/Archgenpsychiatry.2011.151  0.329
2011 Peter CJ, Akbarian S. Balancing histone methylation activities in psychiatric disorders. Trends in Molecular Medicine. 17: 372-9. PMID 21429800 DOI: 10.1016/j.molmed.2011.02.003  0.428
2011 Akbarian S. Epigenetics of schizophrenia. Current Topics in Behavioral Neurosciences. 4: 611-28. PMID 21312415 DOI: 10.1007/7854_2010_38  0.466
2011 Connor CM, Crawford BC, Akbarian S. White matter neuron alterations in schizophrenia and related disorders. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 29: 325-34. PMID 20691252 DOI: 10.1016/j.ijdevneu.2010.07.236  0.36
2010 Jiang Y, Matevossian A, Guo Y, Akbarian S. Setdb1-mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2-deficient mice. Neuropharmacology. 60: 1088-97. PMID 20869373 DOI: 10.1016/j.neuropharm.2010.09.020  0.37
2010 Jiang Y, Jakovcevski M, Bharadwaj R, Connor C, Schroeder FA, Lin CL, Straubhaar J, Martin G, Akbarian S. Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B Journal of Neuroscience. 30: 7152-7167. PMID 20505083 DOI: 10.1523/Jneurosci.1314-10.2010  0.327
2010 Cheung I, Shulha HP, Jiang Y, Matevossian A, Wang J, Weng Z, Akbarian S. Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America. 107: 8824-9. PMID 20421462 DOI: 10.1073/Pnas.1001702107  0.388
2009 Akbarian S. The molecular pathology of schizophrenia--focus on histone and DNA modifications. Brain Research Bulletin. 83: 103-7. PMID 19729053 DOI: 10.1016/j.brainresbull.2009.08.018  0.446
2009 Connor CM, Guo Y, Akbarian S. Cingulate White Matter Neurons in Schizophrenia and Bipolar Disorder Biological Psychiatry. 66: 486-493. PMID 19559403 DOI: 10.1016/j.biopsych.2009.04.032  0.346
2009 Mellios N, Huang HS, Baker SP, Galdzicka M, Ginns E, Akbarian S. Molecular determinants of dysregulated GABAergic gene expression in the prefrontal cortex of subjects with schizophrenia. Biological Psychiatry. 65: 1006-14. PMID 19121517 DOI: 10.1016/j.biopsych.2008.11.019  0.315
2009 Akbarian S, Huang HS. Epigenetic Regulation in Human Brain-Focus on Histone Lysine Methylation Biological Psychiatry. 65: 198-203. PMID 18814864 DOI: 10.1016/j.biopsych.2008.08.015  0.424
2008 Matevossian A, Akbarian S. Neuronal nuclei isolation from human postmortem brain tissue. Journal of Visualized Experiments : Jove. PMID 19078943 DOI: 10.3791/914  0.335
2008 Matevossian A, Akbarian S. A chromatin assay for human brain tissue. Journal of Visualized Experiments : Jove. PMID 19066569 DOI: 10.3791/717  0.411
2008 Jiang Y, Langley B, Lubin FD, Renthal W, Wood MA, Yasui DH, Kumar A, Nestler EJ, Akbarian S, Beckel-Mitchener AC. Epigenetics in the nervous system. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 11753-9. PMID 19005036 DOI: 10.1523/Jneurosci.3797-08.2008  0.352
2008 Jiang Y, Matevossian A, Huang HS, Straubhaar J, Akbarian S. Isolation of neuronal chromatin from brain tissue. Bmc Neuroscience. 9: 42. PMID 18442397 DOI: 10.1186/1471-2202-9-42  0.339
2008 Connor CM, Akbarian S. DNA methylation changes in schizophrenia and bipolar disorder Epigenetics. 3: 55-58. PMID 18398310  0.41
2008 Akbarian S, Jiang Y, Laforet G. The molecular pathology of Rett syndrome: synopsis and update. Neuromolecular Medicine. 8: 485-94. PMID 17028371 DOI: 10.1385/NMM:8:4:485  0.308
2007 Huang HS, Matevossian A, Whittle C, Kim SY, Schumacher A, Baker SP, Akbarian S. Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 11254-62. PMID 17942719 DOI: 10.1523/JNEUROSCI.3272-07.2007  0.424
2007 Siegmund KD, Connor CM, Campan M, Long TI, Weisenberger DJ, Biniszkiewicz D, Jaenisch R, Laird PW, Akbarian S. DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. Plos One. 2: e895. PMID 17878930 DOI: 10.1371/Journal.Pone.0000895  0.333
2007 Huang HS, Akbarian S. GAD1 mRNA expression and DNA methylation in prefrontal cortex of subjects with schizophrenia Plos One. 2. PMID 17726539 DOI: 10.1371/journal.pone.0000809  0.394
2006 Akbarian S, Huang HS. Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders Brain Research Reviews. 52: 293-304. PMID 16759710 DOI: 10.1016/j.brainresrev.2006.04.001  0.396
2006 Huang HS, Matevossian A, Jiang Y, Akbarian S. Chromatin immunoprecipitation in postmortem brain. Journal of Neuroscience Methods. 156: 284-92. PMID 16574239 DOI: 10.1016/j.jneumeth.2006.02.018  0.348
2005 Akbarian S, Ruehl MG, Bliven E, Luiz LA, Peranelli AC, Baker SP, Roberts RC, Bunney WE, Conley RC, Jones EG, Tamminga CA, Guo Y. Chromatin alterations associated with down-regulated metabolic gene expression in the prefrontal cortex of subjects with schizophrenia. Archives of General Psychiatry. 62: 829-40. PMID 16061760 DOI: 10.1001/Archpsyc.62.8.829  0.367
2005 Stadler F, Kolb G, Rubusch L, Baker SP, Jones EG, Akbarian S. Histone methylation at gene promoters is associated with developmental regulation and region-specific expression of ionotropic and metabotropic glutamate receptors in human brain. Journal of Neurochemistry. 94: 324-36. PMID 15998284 DOI: 10.1111/j.1471-4159.2005.03190.x  0.364
2003 Akbarian S. The neurobiology of Rett syndrome. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 9: 57-63. PMID 12580340 DOI: 10.1177/1073858402239591  0.378
Low-probability matches (unlikely to be authored by this person)
2002 Tudor M, Akbarian S, Chen RZ, Jaenisch R. Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain. Proceedings of the National Academy of Sciences of the United States of America. 99: 15536-41. PMID 12432090 DOI: 10.1073/Pnas.242566899  0.295
2011 Marder SR, Roth B, Sullivan PF, Scolnick EM, Nestler EJ, Geyer MA, Welnberger DR, Karayiorgou M, Guidotti A, Gingrich J, Akbarian S, Buchanan RW, Lieberman JA, Conn PJ, Haggarty SJ, et al. Advancing drug discovery for schizophrenia. Annals of the New York Academy of Sciences. 1236: 30-43. PMID 22032400 DOI: 10.1111/J.1749-6632.2011.06216.X  0.294
2023 LaMarca EA, Saito A, Plaza-Jennings A, Espeso-Gil S, Hellmich A, Fernando MB, Javidfar B, Liao W, Estill M, Townsley K, Florio A, Ethridge JE, Do C, Tycko B, Shen L, ... ... Akbarian S, et al. R-loop landscapes in the developing human brain are linked to neural differentiation and cell-type specific transcription. Biorxiv : the Preprint Server For Biology. PMID 37503149 DOI: 10.1101/2023.07.18.549494  0.293
2019 Akbarian S. Special volume: The genomics and epigenomics of schizophrenia. Schizophrenia Research. 217: 1-3. PMID 31813801 DOI: 10.1016/j.schres.2019.11.056  0.29
2015 Sharp AJ, Akbarian S. Back to the past in schizophrenia genomics. Nature Neuroscience. 19: 1-2. PMID 26713739 DOI: 10.1038/nn.4203  0.288
2022 Chou MY, Hu MC, Chen PY, Hsu CL, Lin TY, Tan MJ, Lee CY, Kuo MF, Huang PH, Wu VC, Yang SH, Fan PC, Huang HY, Akbarian S, Loo TH, et al. RTL1/PEG11 imprinted in human and mouse brain mediates anxiety-like and social behaviors and regulates neuronal excitability in the locus coeruleus. Human Molecular Genetics. PMID 35567414 DOI: 10.1093/hmg/ddac110  0.287
2022 Blaze J, Akbarian S. The tRNA regulome in neurodevelopmental and neuropsychiatric disease. Molecular Psychiatry. PMID 35505091 DOI: 10.1038/s41380-022-01585-9  0.286
2010 Jakovcevski M, Guo Y, Su Q, Gao G, Akbarian S. rAAV9--a human-derived adeno-associated virus vector for efficient transgene expression in mouse cingulate cortex. Cold Spring Harbor Protocols. 2010: pdb.prot5417. PMID 20360371 DOI: 10.1101/Pdb.Prot5417  0.286
2022 Kim YA, Siddiqui T, Blaze J, Cosacak MI, Winters T, Kumar A, Tein E, Sproul AA, Teich AF, Bartolini F, Akbarian S, Kizil C, Hargus G, Santa-Maria I. RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation. Acta Neuropathologica. PMID 36357715 DOI: 10.1007/s00401-022-02511-7  0.285
2021 Akbarian S. Epigenetic Clocks in Schizophrenia: Promising Biomarkers, Foggy Clockwork. Biological Psychiatry. 88: 210-211. PMID 32674842 DOI: 10.1016/j.biopsych.2020.04.004  0.283
2023 Wei J, Lambert TY, Valada A, Patel N, Walker K, Lenders J, Schmidt CJ, Iskhakova M, Alazizi A, Mair-Meijers H, Mash DC, Luca F, Pique-Regi R, Bannon MJ, Akbarian S. Single Nucleus Transcriptomics Reveals Pervasive Glial Activation in Opioid Overdose Cases. Biorxiv : the Preprint Server For Biology. PMID 36945611 DOI: 10.1101/2023.03.07.531400  0.282
2022 Plaza-Jennings AL, Valada A, O'Shea C, Iskhakova M, Hu B, Javidfar B, Ben Hutta G, Lambert TY, Murray J, Kassim B, Chandrasekaran S, Chen BK, Morgello S, Won H, Akbarian S. HIV integration in the human brain is linked to microglial activation and 3D genome remodeling. Molecular Cell. 82: 4647-4663.e8. PMID 36525955 DOI: 10.1016/j.molcel.2022.11.016  0.278
2018 Yu Q, He Z, Zubkov D, Huang S, Kurochkin I, Yang X, Halene T, Willmitzer L, Giavalisco P, Akbarian S, Khaitovich P. Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders. Molecular Psychiatry. PMID 30089790 DOI: 10.1038/S41380-018-0200-8  0.275
2022 Bae T, Fasching L, Wang Y, Shin JH, Suvakov M, Jang Y, Norton S, Dias C, Mariani J, Jourdon A, Wu F, Panda A, Pattni R, Chahine Y, Yeh R, ... ... Akbarian S, et al. Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability. Science (New York, N.Y.). 377: 511-517. PMID 35901164 DOI: 10.1126/science.abm6222  0.274
2023 Hou KC, Tsai MH, Akbarian S, Huang HS. Mir125b-1 is not imprinted in human brain and shows developmental expression changes in mouse brain. Neuroscience. PMID 37598835 DOI: 10.1016/j.neuroscience.2023.08.014  0.273
2009 Akbarian S. Restoring GABAergic signaling and neuronal synchrony in schizophrenia. The American Journal of Psychiatry. 165: 1507-9. PMID 19047328 DOI: 10.1176/appi.ajp.2008.08081225  0.268
2022 Voloudakis G, Vicari JM, Venkatesh S, Hoffman GE, Dobrindt K, Zhang W, Beckmann ND, Higgins CA, Argyriou S, Jiang S, Hoagland D, Gao L, Corvelo A, Cho K, Lee KM, ... ... Akbarian S, et al. A translational genomics approach identifies IL10RB as the top candidate gene target for COVID-19 susceptibility. Npj Genomic Medicine. 7: 52. PMID 36064543 DOI: 10.1038/s41525-022-00324-x  0.267
2014 Akbarian S, Lubin F. Preface. Epigenetics and neuroplasticity--evidence and debate. Progress in Molecular Biology and Translational Science. 128: xi-xiii. PMID 25410547 DOI: 10.1016/B978-0-12-800977-2.10000-2  0.263
2007 Schroeder FA, Lin CL, Crusio WE, Akbarian S. Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse. Biological Psychiatry. 62: 55-64. PMID 16945350 DOI: 10.1016/j.biopsych.2006.06.036  0.261
2012 Qin J, Whyte WA, Anderssen E, Apostolou E, Chen HH, Akbarian S, Bronson RT, Hochedlinger K, Ramaswamy S, Young RA, Hock H. The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell. 11: 319-32. PMID 22770845 DOI: 10.1016/J.Stem.2012.06.002  0.258
2010 Qin J, Van Buren D, Huang HS, Zhong L, Mostoslavsky R, Akbarian S, Hock H. Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice. The Journal of Biological Chemistry. 285: 27767-75. PMID 20592034 DOI: 10.1074/Jbc.M110.115410  0.258
2018 Lin CY, Chang KW, Lin CY, Wu JY, Coon H, Huang PH, Ho HN, Akbarian S, Gau SS, Huang HS. Allele-specific expression in a family quartet with autism reveals mono-to-biallelic switch and novel transcriptional processes of autism susceptibility genes. Scientific Reports. 8: 4277. PMID 29523860 DOI: 10.1038/s41598-018-22753-4  0.255
2015 de Boni L, Riedel L, Schmitt I, Kraus TF, Kaut O, Piston D, Akbarian S, Wüllner U. DNA methylation levels of α-synuclein intron 1 in the aging brain. Neurobiology of Aging. 36: 3334.e7-3334.e11. PMID 26422361 DOI: 10.1016/j.neurobiolaging.2015.08.028  0.255
2004 Li J, Guo Y, Schroeder FA, Youngs RM, Schmidt TW, Ferris C, Konradi C, Akbarian S. Dopamine D2-like antagonists induce chromatin remodeling in striatal neurons through cyclic AMP-protein kinase A and NMDA receptor signaling. Journal of Neurochemistry. 90: 1117-31. PMID 15312167 DOI: 10.1111/j.1471-4159.2004.02569.x  0.254
2022 Reichenberg A, Akbarian S. Towards DSM 10: A bio-classification of developmental schizophrenia? Schizophrenia Research. 242: 4-6. PMID 34991947 DOI: 10.1016/j.schres.2021.12.006  0.251
2021 Mussa Z, Tome-Garcia J, Jiang Y, Akbarian S, Tsankova NM. Isolation of Adult Human Astrocyte Populations from Fresh-frozen Cortex using Fluorescence-Activated Nuclei Sorting. Journal of Visualized Experiments : Jove. PMID 33938880 DOI: 10.3791/62405  0.25
2002 Akbarian S, Rios M, Liu RJ, Gold SJ, Fong HF, Zeiler S, Coppola V, Tessarollo L, Jones KR, Nestler EJ, Aghajanian GK, Jaenisch R. Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 4153-62. PMID 12019333 DOI: 10.1523/Jneurosci.22-10-04153.2002  0.249
2010 Connor C, Cheung I, Simon A, Jakovcevski M, Weng Z, Akbarian S. A simple method for improving the specificity of anti-methyl histone antibodies. Epigenetics. 5: 392-5. PMID 20458167 DOI: 10.4161/Epi.5.5.11874  0.249
2023 Chou MY, Cao X, Hou KC, Tsai MH, Lee CY, Kuo MF, Wu VC, Huang HY, Akbarian S, Chang SK, Hu CY, Lin SW, Huang HS. Mir125b-2 imprinted in human but not mouse brain regulates hippocampal function and circuit in mice. Communications Biology. 6: 267. PMID 36918719 DOI: 10.1038/s42003-023-04655-y  0.247
2015 Koike H, Demars MP, Short JA, Nabel EM, Akbarian S, Baxter MG, Morishita H. Chemogenetic Inactivation of Dorsal Anterior Cingulate Cortex Neurons Disrupts Attentional Behavior in Mouse. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26224620 DOI: 10.1038/Npp.2015.229  0.245
2022 Sey NYA, Hu B, Iskhakova M, Lee S, Sun H, Shokrian N, Ben Hutta G, Marks JA, Quach BC, Johnson EO, Hancock DB, Akbarian S, Won H. Chromatin architecture in addiction circuitry identifies risk genes and potential biological mechanisms underlying cigarette smoking and alcohol use traits. Molecular Psychiatry. PMID 35422469 DOI: 10.1038/s41380-022-01558-y  0.239
2022 Pai B, Tome-Garcia J, Cheng WS, Nudelman G, Beaumont KG, Ghatan S, Panov F, Caballero E, Sarpong K, Marcuse L, Yoo J, Jiang Y, Schaefer A, Akbarian S, Sebra R, et al. High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy. Acta Neuropathologica Communications. 10: 149. PMID 36274170 DOI: 10.1186/s40478-022-01453-1  0.239
2010 Huang HS, Cheung I, Akbarian S. RPP25 is developmentally regulated in prefrontal cortex and expressed at decreased levels in autism spectrum disorder. Autism Research : Official Journal of the International Society For Autism Research. 3: 153-61. PMID 20632321 DOI: 10.1002/aur.141  0.238
2016 Schmitt A, Martins-de-Souza D, Akbarian S, Cassoli JS, Ehrenreich H, Fischer A, Fonteh A, Gattaz WF, Gawlik M, Gerlach M, Grünblatt E, Halene T, Hasan A, Hashimoto K, Kim YK, et al. Consensus paper of the WFSBP Task Force on Biological Markers: Criteria for biomarkers and endophenotypes of schizophrenia, part III: Molecular mechanisms. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 1-27. PMID 27782767 DOI: 10.1080/15622975.2016.1224929  0.237
2020 Rabin R, Radmanesh A, Glass IA, Dobyns WB, Aldinger KA, Shieh JT, Romoser S, Bombei H, Dowsett L, Trapane P, Bernat JA, Baker J, Mendelsohn NJ, Popp B, Siekmeyer M, ... ... Akbarian S, et al. Genotype-phenotype correlation at codon 1740 of SETD2. American Journal of Medical Genetics. Part A. PMID 32710489 DOI: 10.1002/ajmg.a.61724  0.237
2008 Schroeder FA, Penta KL, Matevossian A, Jones SR, Konradi C, Tapper AR, Akbarian S. Drug-induced activation of dopamine D(1) receptor signaling and inhibition of class I/II histone deacetylase induce chromatin remodeling in reward circuitry and modulate cocaine-related behaviors. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 2981-92. PMID 18288092 DOI: 10.1038/npp.2008.15  0.234
2024 Blaze J, Browne CJ, Futamura R, Javidfar B, Zachariou V, Nestler EJ, Akbarian S. tRNA epitranscriptomic alterations associated with opioid-induced reward-seeking and long-term opioid withdrawal in male mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 38332016 DOI: 10.1038/s41386-024-01813-6  0.233
2006 Shimazu K, Zhao M, Sakata K, Akbarian S, Bates B, Jaenisch R, Lu B. NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis. Learning & Memory (Cold Spring Harbor, N.Y.). 13: 307-15. PMID 16705139 DOI: 10.1101/Lm.76006  0.232
2015 Bicks LK, Koike H, Akbarian S, Morishita H. Prefrontal Cortex and Social Cognition in Mouse and Man. Frontiers in Psychology. 6: 1805. PMID 26635701 DOI: 10.3389/Fpsyg.2015.01805  0.229
2002 Albert KA, Hemmings HC, Adamo AI, Potkin SG, Akbarian S, Sandman CA, Cotman CW, Bunney WE, Greengard P. Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia. Archives of General Psychiatry. 59: 705-12. PMID 12150646 DOI: 10.1001/Archpsyc.59.8.705  0.227
2021 Palmer RHC, Johnson EC, Won H, Polimanti R, Kapoor M, Chitre A, Bogue MA, Benca-Bachman CE, Parker CC, Ursu O, Verma A, Reynolds T, Ernst J, Bray M, Kwon SB, ... ... Akbarian S, et al. Integration of Evidence across Human and Model Organism Studies: A Meeting Report. Genes, Brain, and Behavior. e12738. PMID 33893716 DOI: 10.1111/gbb.12738  0.213
2022 Corradin O, Sallari R, Hoang AT, Kassim BS, Ben Hutta G, Cuoto L, Quach BC, Lovrenert K, Hays C, Gryder BE, Iskhakova M, Cates H, Song Y, Bartels CF, Hancock DB, ... ... Akbarian S, et al. Convergence of case-specific epigenetic alterations identify a confluence of genetic vulnerabilities tied to opioid overdose. Molecular Psychiatry. PMID 35301427 DOI: 10.1038/s41380-022-01477-y  0.213
2006 Rios M, Lambe EK, Liu R, Teillon S, Liu J, Akbarian S, Roffler-Tarlov S, Jaenisch R, Aghajanian GK. Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice. Journal of Neurobiology. 66: 408-20. PMID 16408297 DOI: 10.1002/Neu.20233  0.21
2012 Mellios N, Galdzicka M, Ginns E, Baker SP, Rogaev E, Xu J, Akbarian S. Gender-specific reduction of estrogen-sensitive small RNA, miR-30b, in subjects with schizophrenia. Schizophrenia Bulletin. 38: 433-43. PMID 20732949 DOI: 10.1093/schbul/sbq091  0.208
2020 Yamamuro K, Bicks LK, Leventhal MB, Kato D, Im S, Flanigan ME, Garkun Y, Norman KJ, Caro K, Sadahiro M, Kullander K, Akbarian S, Russo SJ, Morishita H. A prefrontal-paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice. Nature Neuroscience. PMID 32868932 DOI: 10.1038/S41593-020-0695-6  0.208
2016 Labadorf A, Hoss AG, Lagomarsino V, Latourelle JC, Hadzi TC, Bregu J, MacDonald ME, Gusella JF, Chen JF, Akbarian S, Weng Z, Myers RH. Correction: RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression. Plos One. 11: e0160295. PMID 27454300 DOI: 10.1371/journal.pone.0160295  0.206
2014 Ginns EI, Mak SK, Ko N, Karlgren J, Akbarian S, Chou VP, Guo Y, Lim A, Samuelsson S, LaMarca ML, Vazquez-DeRose J, Manning-BoÄŸ AB. Neuroinflammation and α-synuclein accumulation in response to glucocerebrosidase deficiency are accompanied by synaptic dysfunction. Molecular Genetics and Metabolism. 111: 152-62. PMID 24388731 DOI: 10.1016/j.ymgme.2013.12.003  0.198
2013 Udagawa T, Farny NG, Jakovcevski M, Kaphzan H, Alarcon JM, Anilkumar S, Ivshina M, Hurt JA, Nagaoka K, Nalavadi VC, Lorenz LJ, Bassell GJ, Akbarian S, Chattarji S, Klann E, et al. Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology. Nature Medicine. 19: 1473-7. PMID 24141422 DOI: 10.1038/Nm.3353  0.198
2017 Walsh RM, Shen EY, Bagot RC, Anselmo A, Jiang Y, Javidfar B, Wojtkiewicz GJ, Cloutier J, Chen JW, Sadreyev R, Nestler EJ, Akbarian S, Hochedlinger K. Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice. Nature Communications. 8: 15142. PMID 28485378 DOI: 10.1038/Ncomms15142  0.198
2019 Kurochkin I, Khrameeva E, Tkachev A, Stepanova V, Vanyushkina A, Stekolshchikova E, Li Q, Zubkov D, Shichkova P, Halene T, Willmitzer L, Giavalisco P, Akbarian S, Khaitovich P. Metabolome signature of autism in the human prefrontal cortex. Communications Biology. 2: 234. PMID 31263778 DOI: 10.1038/s42003-019-0485-4  0.195
2021 Wang Y, Bae T, Thorpe J, Sherman MA, Jones AG, Cho S, Daily K, Dou Y, Ganz J, Galor A, Lobon I, Pattni R, Rosenbluh C, Tomasi S, Tomasini L, ... ... Akbarian S, et al. Comprehensive identification of somatic nucleotide variants in human brain tissue. Genome Biology. 22: 92. PMID 33781308 DOI: 10.1186/s13059-021-02285-3  0.195
2021 Voloudakis G, Hoffman G, Venkatesh S, Lee KM, Dobrindt K, Vicari JM, Zhang W, Beckmann ND, Jiang S, Hoagland D, Bian J, Gao L, Corvelo A, Cho K, Lee JS, ... ... Akbarian S, et al. IL10RB as a key regulator of COVID-19 host susceptibility and severity. Medrxiv : the Preprint Server For Health Sciences. PMID 34100031 DOI: 10.1101/2021.05.31.21254851  0.189
2023 Plaza-Jennings A, Akbarian S. Genomic Exploration of the Brain in People Infected with HIV-Recent Progress and the Road Ahead. Current Hiv/Aids Reports. 20: 357-367. PMID 37947981 DOI: 10.1007/s11904-023-00675-9  0.188
2014 Gascon E, Lynch K, Ruan H, Almeida S, Verheyden JM, Seeley WW, Dickson DW, Petrucelli L, Sun D, Jiao J, Zhou H, Jakovcevski M, Akbarian S, Yao WD, Gao FB. Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia. Nature Medicine. 20: 1444-51. PMID 25401692 DOI: 10.1038/Nm.3717  0.187
2014 Chen CT, Hehnly H, Yu Q, Farkas D, Zheng G, Redick SD, Hung HF, Samtani R, Jurczyk A, Akbarian S, Wise C, Jackson A, Bober M, Guo Y, Lo C, et al. A unique set of centrosome proteins requires pericentrin for spindle-pole localization and spindle orientation. Current Biology : Cb. 24: 2327-34. PMID 25220058 DOI: 10.1016/J.Cub.2014.08.029  0.186
2023 Min AK, Javidfar B, Missall R, Doanman D, Durens M, Graziani M, Mordelt A, Marro SG, de Witte L, Chen BK, Swartz TH, Akbarian S. HIV-1 infection of genetically engineered iPSC-derived central nervous system-engrafted microglia in a humanized mouse model. Journal of Virology. e0159523. PMID 38032195 DOI: 10.1128/jvi.01595-23  0.186
2021 Dobrindt K, Hoagland DA, Seah C, Kassim B, O'Shea CP, Murphy A, Iskhakova M, Fernando MB, Powell SK, Deans PJM, Javidfar B, Peter C, Møller R, Uhl SA, Garcia MF, ... ... Akbarian S, et al. Common genetic variation in humans impacts in vitro susceptibility to SARS-CoV-2 infection. Stem Cell Reports. PMID 33636110 DOI: 10.1016/j.stemcr.2021.02.010  0.186
2023 Akbarian S, Won H. Chromosomal contacts change with age. Science (New York, N.Y.). 381: 1049-1050. PMID 37676934 DOI: 10.1126/science.adk0961  0.165
2021 Bicks LK, Peng M, Taub A, Akbarian S, Morishita H. An Adolescent Sensitive Period for Social Dominance Hierarchy Plasticity Is Regulated by Cortical Plasticity Modulators in Mice. Frontiers in Neural Circuits. 15: 676308. PMID 34054438 DOI: 10.3389/fncir.2021.676308  0.164
2009 Febo M, Akbarian S, Schroeder FA, Ferris CF. Cocaine-induced metabolic activation in cortico-limbic circuitry is increased after exposure to the histone deacetylase inhibitor, sodium butyrate. Neuroscience Letters. 465: 267-71. PMID 19638299 DOI: 10.1016/J.Neulet.2009.07.065  0.163
2023 Min AK, Javidfar B, Missall R, Doanman D, Durens M, Vil SS, Masih Z, Graziani M, Mordelt A, Marro S, de Witte L, Chen BK, Swartz TH, Akbarian S. HIV-1 infection of genetically engineered iPSC-derived central nervous system-engrafted microglia in a humanized mouse model. Biorxiv : the Preprint Server For Biology. PMID 37162838 DOI: 10.1101/2023.04.26.538461  0.163
2022 Sey NYA, Hu B, Iskhakova M, Lee S, Sun H, Shokrian N, Ben Hutta G, Marks JA, Quach BC, Johnson EO, Hancock DB, Akbarian S, Won H. Correction: Chromatin architecture in addiction circuitry identifies risk genes and potential biological mechanisms underlying cigarette smoking and alcohol use traits. Molecular Psychiatry. PMID 35794187 DOI: 10.1038/s41380-022-01678-5  0.159
2021 Fullard JF, Lee HC, Voloudakis G, Suo S, Javidfar B, Shao Z, Peter C, Zhang W, Jiang S, Corvelo A, Wargnier H, Woodoff-Leith E, Purohit DP, Ahuja S, Tsankova NM, ... ... Akbarian S, et al. Single-nucleus transcriptome analysis of human brain immune response in patients with severe COVID-19. Genome Medicine. 13: 118. PMID 34281603 DOI: 10.1186/s13073-021-00933-8  0.158
2002 Akbarian S. Diseases of the mind and brain: Rett's syndrome. The American Journal of Psychiatry. 159: 1103. PMID 12091185 DOI: 10.1176/appi.ajp.159.7.1103  0.156
2022 Zajicek AS, Ruan H, Dai H, Skolfield MC, Phillips HL, Burnette WJ, Javidfar B, Sun SC, Akbarian S, Yao WD. Cylindromatosis drives synapse pruning and weakening by promoting macroautophagy through Akt-mTOR signaling. Molecular Psychiatry. PMID 35449295 DOI: 10.1038/s41380-022-01571-1  0.154
2010 Yang C, Tan W, Whittle C, Qiu L, Cao L, Akbarian S, Xu Z. The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism. Plos One. 5: e15878. PMID 21209826 DOI: 10.1371/journal.pone.0015878  0.149
2002 Bates B, Hirt L, Thomas SS, Akbarian S, Le D, Amin-Hanjani S, Whalen M, Jaenisch R, Moskowitz MA. Neurotrophin-3 promotes cell death induced in cerebral ischemia, oxygen-glucose deprivation, and oxidative stress: possible involvement of oxygen free radicals. Neurobiology of Disease. 9: 24-37. PMID 11848682 DOI: 10.1006/Nbdi.2001.0458  0.148
2002 Akbarian S. Diseases of the mind and brain: Rett's syndrome, part II. The American Journal of Psychiatry. 159: 1294. PMID 12153818 DOI: 10.1176/appi.ajp.159.8.1294  0.146
2008 Mellios N, Huang HS, Grigorenko A, Rogaev E, Akbarian S. A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex. Human Molecular Genetics. 17: 3030-42. PMID 18632683 DOI: 10.1093/hmg/ddn201  0.142
2014 Hoss AG, Kartha VK, Dong X, Latourelle JC, Dumitriu A, Hadzi TC, Macdonald ME, Gusella JF, Akbarian S, Chen JF, Weng Z, Myers RH. MicroRNAs located in the Hox gene clusters are implicated in huntington's disease pathogenesis. Plos Genetics. 10: e1004188. PMID 24586208 DOI: 10.1371/Journal.Pgen.1004188  0.14
2010 Akbarian S, Davis RJ. Keep the 'phospho' on MAPK, be happy. Nature Medicine. 16: 1187-8. PMID 21052065 DOI: 10.1038/Nm1110-1187  0.14
2003 Akbarian S. Clinical experts on Rett disorder. Pediatric Rehabilitation. 5: 117-8. PMID 12596822 DOI: 10.1080/1363849021000033313  0.14
2022 Wickramasinghe NM, Sachs D, Shewale B, Gonzalez DM, Dhanan-Krishnan P, Torre D, LaMarca E, Raimo S, Dariolli R, Serasinghe MN, Mayourian J, Sebra R, Beaumont K, Iyengar S, French DL, ... ... Akbarian S, et al. PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem-cell-derived cardiomyocytes. Cell Stem Cell. PMID 35325615 DOI: 10.1016/j.stem.2022.02.011  0.132
2015 Hoss AG, Labadorf A, Latourelle JC, Kartha VK, Hadzi TC, Gusella JF, MacDonald ME, Chen JF, Akbarian S, Weng Z, Vonsattel JP, Myers RH. miR-10b-5p expression in Huntington's disease brain relates to age of onset and the extent of striatal involvement. Bmc Medical Genomics. 8: 10. PMID 25889241 DOI: 10.1186/S12920-015-0083-3  0.126
2012 Rane P, Shields J, Heffernan M, Guo Y, Akbarian S, King JA. The histone deacetylase inhibitor, sodium butyrate, alleviates cognitive deficits in pre-motor stage PD. Neuropharmacology. 62: 2409-12. PMID 22353286 DOI: 10.1016/j.neuropharm.2012.01.026  0.121
2020 Bicks LK, Yamamuro K, Flanigan ME, Kim JM, Kato D, Lucas EK, Koike H, Peng MS, Brady DM, Chandrasekaran S, Norman KJ, Smith MR, Clem RL, Russo SJ, Akbarian S, et al. Prefrontal parvalbumin interneurons require juvenile social experience to establish adult social behavior. Nature Communications. 11: 1003. PMID 32081848 DOI: 10.1038/S41467-020-14740-Z  0.109
2022 Pai B, Tome-Garcia J, Cheng WS, Nudelman G, Beaumont KG, Ghatan S, Panov F, Caballero E, Sarpong K, Marcuse L, Yoo J, Jiang Y, Schaefer A, Akbarian S, Sebra R, et al. Correction: High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy. Acta Neuropathologica Communications. 10: 171. PMID 36443832 DOI: 10.1186/s40478-022-01479-5  0.091
2013 Hope BT, Skinner MK, Kenny PJ, Akbarian S. Exploring the epigenetics of cocaine resistance. Nature Medicine. 19: 136-7. PMID 23389607 DOI: 10.1038/Nm.3091  0.071
2008 Akbarian S. Approaching the molecular pathology of suicide. Biological Psychiatry. 64: 643-644. PMID 18926170 DOI: 10.1016/j.biopsych.2008.06.013  0.068
2016 Chandrasekaran S, Akbarian S. Insulin-like Growth Factor 1 for Healthy Spines and Healthy Minds? Biological Psychiatry. 80: 260-2. PMID 27468627 DOI: 10.1016/j.biopsych.2016.06.002  0.041
2013 Akbarian S, Halene T. The neuroepigenetics of suicide. The American Journal of Psychiatry. 170: 462-5. PMID 23632831 DOI: 10.1176/appi.ajp.2013.13020235  0.033
2016 Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AF, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA, Carter CS, Cook EH, Daskalakis ZJ, DiLeone RJ, Duman RS, et al. Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research. Biological Psychiatry. 80: 84-6. PMID 27346079 DOI: 10.1016/J.Biopsych.2016.05.004  0.024
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