Stuart H. Orkin, M.D. - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 
Area:
Genetics, Molecular Biology, Neuroscience Biology
Website:
http://www.dfhcc.harvard.edu/insider/member-detail/member/stuart-h-orkin-md/

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Year Citation  Score
2021 Liu N, Xu S, Yao Q, Zhu Q, Kai Y, Hsu JY, Sakon P, Pinello L, Yuan GC, Bauer DE, Orkin SH. Author Correction: Transcription factor competition at the γ-globin promoters controls hemoglobin switching. Nature Genetics. PMID 33731942 DOI: 10.1038/s41588-021-00834-x  0.64
2021 Liu N, Xu S, Yao Q, Zhu Q, Kai Y, Hsu JY, Sakon P, Pinello L, Yuan GC, Bauer DE, Orkin SH. Transcription factor competition at the γ-globin promoters controls hemoglobin switching. Nature Genetics. PMID 33649594 DOI: 10.1038/s41588-021-00798-y  0.64
2020 Terzi Cizmecioglu N, Huang J, Keskin EG, Wang X, Esen I, Chen F, Orkin SH. ARID4B is critical for mouse embryonic stem cell differentiation towards mesoderm and endoderm, linking epigenetics to pluripotency exit. The Journal of Biological Chemistry. 295: 17738-17751. PMID 33454011 DOI: 10.1074/jbc.RA120.015534  0.76
2020 Terzi Cizmecioglu N, Huang J, Keskin EG, Wang X, Esen I, Chen F, Orkin SH. Arid4b is critical for mouse embryonic stem cell differentiation towards mesoderm and endoderm, linking epigenetics to pluripotency exit. The Journal of Biological Chemistry. PMID 33060200 DOI: 10.1074/jbc.RA120.015534  0.76
2020 Canver MC, Tripathi P, Bullen MJ, Olshansky M, Kumar Y, Wong LH, Turner SJ, Lessard S, Pinello L, Orkin SH, Das PP. A saturating mutagenesis CRISPR-Cas9 mediated functional genomic screen identifies cis- and trans-regulatory elements of Oct4 in murine ESCs. The Journal of Biological Chemistry. PMID 32994224 DOI: 10.1074/jbc.RA120.013772  0.48
2020 Cai W, Huang J, Zhu Q, Li BE, Seruggia D, Zhou P, Nguyen M, Fujiwara Y, Xie H, Yang Z, Hong D, Ren P, Xu J, Pu WT, Yuan GC, ... Orkin SH, et al. Enhancer dependence of cell-type-specific gene expression increases with developmental age. Proceedings of the National Academy of Sciences of the United States of America. PMID 32817427 DOI: 10.1073/Pnas.2008672117  1
2020 Bowling S, Sritharan D, Osorio FG, Nguyen M, Cheung P, Rodriguez-Fraticelli A, Patel S, Yuan WC, Fujiwara Y, Li BE, Orkin SH, Hormoz S, Camargo FD. An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells. Cell. 181: 1693-1694. PMID 32589959 DOI: 10.1016/j.cell.2020.06.018  1
2020 Bowling S, Sritharan D, Osorio FG, Nguyen M, Cheung P, Rodriguez-Fraticelli A, Patel S, Yuan WC, Fujiwara Y, Li BE, Orkin SH, Hormoz S, Camargo FD. An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells. Cell. PMID 32413320 DOI: 10.1016/J.Cell.2020.04.048  1
2020 Liu X, Chen Y, Zhang Y, Liu Y, Liu N, Botten GA, Cao H, Orkin SH, Zhang MQ, Xu J. Multiplexed capture of spatial configuration and temporal dynamics of locus-specific 3D chromatin by biotinylated dCas9. Genome Biology. 21: 59. PMID 32138752 DOI: 10.1186/S13059-020-01973-W  1
2020 Christodoulou C, Spencer JA, Yeh SA, Turcotte R, Kokkaliaris KD, Panero R, Ramos A, Guo G, Seyedhassantehrani N, Esipova TV, Vinogradov SA, Rudzinskas S, Zhang Y, Perkins AS, Orkin SH, et al. Live-animal imaging of native haematopoietic stem and progenitor cells. Nature. PMID 32025033 DOI: 10.1038/S41586-020-1971-Z  0.44
2020 Basak A, Munschauer M, Lareau CA, Montbleau KE, Ulirsch JC, Hartigan CR, Schenone M, Lian J, Wang Y, Huang Y, Wu X, Gehrke L, Rice CM, An X, Christou HA, ... ... Orkin SH, et al. Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation. Nature Genetics. PMID 31959994 DOI: 10.1038/S41588-019-0568-7  0.64
2019 Zhu Q, Liu N, Orkin SH, Yuan GC. CUT&RUNTools: a flexible pipeline for CUT&RUN processing and footprint analysis. Genome Biology. 20: 192. PMID 31500663 DOI: 10.1186/S13059-019-1802-4  0.64
2019 Debruyne DN, Dries R, Sengupta S, Seruggia D, Gao Y, Sharma B, Huang H, Moreau L, McLane M, Day DS, Marco E, Chen T, Gray NS, Wong KK, Orkin SH, et al. BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells. Nature. PMID 31391581 DOI: 10.1038/S41586-019-1472-0  0.88
2019 Sher F, Hossain M, Seruggia D, Schoonenberg VAC, Yao Q, Cifani P, Dassama LMK, Cole MA, Ren C, Vinjamur DS, Macias-Trevino C, Luk K, McGuckin C, Schupp PG, Canver MC, ... ... Orkin SH, et al. Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis. Nature Genetics. PMID 31253978 DOI: 10.1038/S41588-019-0453-4  1
2019 Seruggia D, Oti M, Tripathi P, Canver MC, LeBlanc L, Di Giammartino DC, Bullen MJ, Nefzger CM, Sun YBY, Farouni R, Polo JM, Pinello L, Apostolou E, Kim J, Orkin SH, et al. TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network. Molecular Cell. PMID 31005419 DOI: 10.1016/J.Molcel.2019.03.025  1
2019 Jadhav U, Cavazza A, Banerjee KK, Xie H, O'Neill NK, Saenz-Vash V, Herbert Z, Madha S, Orkin SH, Zhai H, Shivdasani RA. Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA. Molecular Cell. PMID 30905509 DOI: 10.1016/J.Molcel.2019.02.024  0.48
2018 Barros-Silva JD, Linn DE, Steiner I, Guo G, Ali A, Pakula H, Ashton G, Peset I, Brown M, Clarke NW, Bronson RT, Yuan GC, Orkin SH, Li Z, Baena E. Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer. Cell Reports. 25: 3504-3518.e6. PMID 30566873 DOI: 10.1016/J.Celrep.2018.11.069  0.64
2018 LeBlanc L, Lee BK, Yu AC, Kim M, Kambhampati AV, Dupont SM, Seruggia D, Ryu BU, Orkin SH, Kim J. Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation. Elife. 7. PMID 30561326 DOI: 10.7554/Elife.40167  1
2018 Hsu JY, Fulco CP, Cole MA, Canver MC, Pellin D, Sher F, Farouni R, Clement K, Guo JA, Biasco L, Orkin SH, Engreitz JM, Lander ES, Joung JK, Bauer DE, et al. CRISPR-SURF: discovering regulatory elements by deconvolution of CRISPR tiling screen data. Nature Methods. 15: 992-993. PMID 30504875 DOI: 10.1038/S41592-018-0225-6  0.64
2018 Yien YY, Shi J, Chen C, Cheung JT, Grillo AS, Shrestha R, Li L, Zhang X, Kafina MD, Kingsley PD, King MJ, Ablain J, Li H, Zon L, Palis J, ... ... Orkin SH, et al. FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity. The Journal of Biological Chemistry. PMID 30366982 DOI: 10.1074/Jbc.Ra118.002742  1
2018 Singarapu N, Ma K, Reeh KAG, Shen J, Lancaster JN, Yi S, Xie H, Orkin SH, Manley NR, Ehrlich LIR, Jiang N, Richie ER. Polycomb Repressive Complex 2 is essential for development and maintenance of a functional TEC compartment. Scientific Reports. 8: 14335. PMID 30254371 DOI: 10.1038/S41598-018-32729-Z  0.48
2018 Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour A, Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A, Arias E, Pinello L, Katz Y, Shinagare S, Abu-Remaileh M, Mihaylova MM, ... ... Orkin SH, et al. Author Correction: High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. PMID 29849139 DOI: 10.1038/S41586-018-0187-Y  0.64
2018 MacLean GA, McEldoon J, Huang J, Allred J, Canver MC, Orkin SH. Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells. Scientific Reports. 8: 8001. PMID 29789608 DOI: 10.1038/S41598-018-26123-Y  0.76
2018 Han X, Wang R, Zhou Y, Fei L, Sun H, Lai S, Saadatpour A, Zhou Z, Chen H, Ye F, Huang D, Xu Y, Huang W, Jiang M, Jiang X, ... ... Orkin SH, et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell. 173: 1307. PMID 29775597 DOI: 10.1016/j.cell.2018.05.012  0.64
2018 Lu TT, Heyne S, Dror E, Casas E, Leonhardt L, Boenke T, Yang CH, Sagar, Arrigoni L, Dalgaard K, Teperino R, Enders L, Selvaraj M, Ruf M, Raja SJ, ... ... Orkin SH, et al. The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes. Cell Metabolism. PMID 29754954 DOI: 10.1016/J.Cmet.2018.04.013  0.48
2018 Canver MC, Haeussler M, Bauer DE, Orkin SH, Sanjana NE, Shalem O, Yuan GC, Zhang F, Concordet JP, Pinello L. Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments. Nature Protocols. 13: 946-986. PMID 29651054 DOI: 10.1038/Nprot.2018.005  0.64
2018 Liu N, Hargreaves VV, Zhu Q, Kurland JV, Hong J, Kim W, Sher F, Macias-Trevino C, Rogers JM, Kurita R, Nakamura Y, Yuan GC, Bauer DE, Xu J, Bulyk ML, ... Orkin SH, et al. Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch. Cell. PMID 29606353 DOI: 10.1016/J.Cell.2018.03.016  1
2018 Huang J, Li K, Cai W, Liu X, Zhang Y, Orkin SH, Xu J, Yuan GC. Dissecting super-enhancer hierarchy based on chromatin interactions. Nature Communications. 9: 943. PMID 29507293 DOI: 10.1038/S41467-018-03279-9  1
2018 Yamauchi T, Masuda T, Canver MC, Seiler M, Semba Y, Shboul M, Al-Raqad M, Maeda M, Schoonenberg VAC, Cole MA, Macias-Trevino C, Ishikawa Y, Yao Q, Nakano M, Arai F, ... Orkin SH, et al. Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS. Cancer Cell. PMID 29478914 DOI: 10.1016/J.Ccell.2018.01.012  0.48
2018 Han X, Wang R, Zhou Y, Fei L, Sun H, Lai S, Saadatpour A, Zhou Z, Chen H, Ye F, Huang D, Xu Y, Huang W, Jiang M, Jiang X, ... ... Orkin SH, et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell. 172: 1091-1107.e17. PMID 29474909 DOI: 10.1016/J.Cell.2018.02.001  0.64
2018 Vo LT, Kinney MA, Liu X, Zhang Y, Barragan J, Sousa PM, Jha DK, Han A, Cesana M, Shao Z, North TE, Orkin SH, Doulatov S, Xu J, Daley GQ. Regulation of embryonic haematopoietic multipotency by EZH1. Nature. PMID 29342143 DOI: 10.1038/Nature25435  1
2018 LeBlanc L, Lee B, Yu AC, Kim M, Kambhampati AV, Dupont SM, Seruggia D, Ryu BU, Orkin SH, Kim J. Author response: Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation Elife. DOI: 10.7554/Elife.40167.035  1
2018 Hossain M, Sher F, Seruggia D, Schoonenberg V, Cole MA, Cifani P, Dassama L, Macias-Trevino C, Canver MC, Kurita R, Nakamura Y, Pinello L, Maeda T, Kentsis A, Orkin SH, et al. Rational Targeting of a NuRD Sub-Complex for Fetal Hemoglobin Induction Following Comprehensive in Situ Mutagenesis Blood. 132: 2342-2342. DOI: 10.1182/Blood-2018-99-117043  0.88
2017 Pittermann E, Lachmann N, MacLean G, Emmrich S, Ackermann M, Göhring G, Schlegelberger B, Welte K, Schambach A, Heckl D, Orkin SH, Cantz T, Klusmann JH. Gene correction of HAX1 reversed Kostmann disease phenotype in patient-specific induced pluripotent stem cells. Blood Advances. 1: 903-914. PMID 29296734 DOI: 10.1182/Bloodadvances.2016003798  0.56
2017 Lessard S, Francioli L, Alfoldi J, Tardif JC, Ellinor PT, MacArthur DG, Lettre G, Orkin SH, Canver MC. Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci. Proceedings of the National Academy of Sciences of the United States of America. 114: E11257-E11266. PMID 29229813 DOI: 10.1073/Pnas.1714640114  0.36
2017 Moody JD, Levy S, Mathieu J, Xing Y, Kim W, Dong C, Tempel W, Robitaille AM, Dang LT, Ferreccio A, Detraux D, Sidhu S, Zhu L, Carter L, Xu C, ... ... Orkin SH, et al. First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor. Proceedings of the National Academy of Sciences of the United States of America. PMID 28864533 DOI: 10.1073/Pnas.1706907114  0.6
2017 Hsu JH, Hubbell-Engler B, Adelmant G, Huang J, Joyce CE, Vazquez F, Weir BA, Montgomery P, Tsherniak A, Giacomelli AO, Perry JA, Trowbridge J, Fujiwara Y, Cowley GS, Xie H, ... ... Orkin SH, et al. Prmt1-mediated translation regulation is a crucial vulnerability of cancer. Cancer Research. PMID 28655788 DOI: 10.1158/0008-5472.Can-17-0216  1
2017 Han X, Yu H, Huang D, Xu Y, Saadatpour A, Li X, Wang L, Yu J, Pinello L, Lai S, Jiang M, Tian X, Zhang F, Cen Y, Fujiwara Y, ... ... Orkin SH, et al. A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations. Cell Research. 27: 843. PMID 28572571 DOI: 10.1038/cr.2017.78  1
2017 Han X, Yu H, Huang D, Xu Y, Saadatpour A, Li X, Wang L, Yu J, Pinello L, Lai S, Jiang M, Tian X, Zhang F, Cen Y, Fujiwara Y, ... ... Orkin SH, et al. A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations. Cell Research. 27: 842. PMID 28572570 DOI: 10.1038/cr.2017.77  1
2017 Chung J, Wittig JG, Ghamari A, Maeda M, Dailey TA, Bergonia H, Kafina MD, Coughlin EE, Minogue CE, Hebert AS, Li L, Kaplan J, Lodish HF, Bauer DE, Orkin SH, et al. Erythropoietin signaling regulates heme biosynthesis. Elife. 6. PMID 28553927 DOI: 10.7554/Elife.24767  1
2017 Yuan GC, Cai L, Elowitz M, Enver T, Fan G, Guo G, Irizarry R, Kharchenko P, Kim J, Orkin S, Quackenbush J, Saadatpour A, Schroeder T, Shivdasani R, Tirosh I. Challenges and emerging directions in single-cell analysis. Genome Biology. 18: 84. PMID 28482897 DOI: 10.1186/S13059-017-1218-Y  1
2017 Xie Y, Koch ML, Zhang X, Hamblen MJ, Godinho FJ, Fujiwara Y, Xie H, Klusmann JH, Orkin SH, Li Z. Reduced Erg Dosage Impairs Survival of Hematopoietic Stem and Progenitor Cells. Stem Cells (Dayton, Ohio). PMID 28436588 DOI: 10.1002/Stem.2627  1
2017 Ai S, Peng Y, Li C, Gu F, Yu X, Yue Y, Ma Q, Chen J, Lin Z, Zhou P, Xie H, Prendiville TW, Zheng W, Liu Y, Orkin SH, et al. EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent. Elife. 6. PMID 28394251 DOI: 10.7554/Elife.24570  0.64
2017 Canver MC, Bauer DE, Orkin SH. Functional interrogation of non-coding DNA through CRISPR genome editing. Methods (San Diego, Calif.). PMID 28288828 DOI: 10.1016/J.Ymeth.2017.03.008  0.36
2017 Erb MA, Scott TG, Li BE, Xie H, Paulk J, Seo HS, Souza A, Roberts JM, Dastjerdi S, Buckley DL, Sanjana NE, Shalem O, Nabet B, Zeid R, Offei-Addo NK, ... ... Orkin SH, et al. Transcription control by the ENL YEATS domain in acute leukaemia. Nature. PMID 28241139 DOI: 10.1038/Nature21688  0.48
2017 Canver MC, Lessard S, Pinello L, Wu Y, Ilboudo Y, Stern EN, Needleman AJ, Galactéros F, Brugnara C, Kutlar A, McKenzie C, Reid M, Chen DD, Das PP, A Cole M, ... ... Orkin SH, et al. Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci. Nature Genetics. PMID 28218758 DOI: 10.1038/Ng.3793  0.64
2017 Canver MC, Bauer DE, Dass A, Yien YY, Chung J, Masuda T, Maeda T, Paw BH, Orkin SH. Characterization of genomic deletion efficiency mediated by clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells. The Journal of Biological Chemistry. 292: 2556. PMID 28188222 DOI: 10.1074/Jbc.A114.564625  0.36
2017 Han X, Yu H, Huang D, Xu Y, Saadatpour A, Li X, Wang L, Yu J, Pinello L, Lai S, Jiang M, Tian X, Zhang F, Cen Y, Fujiwara Y, ... ... Orkin SH, et al. A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations. Cell Research. PMID 28128194 DOI: 10.1038/Cr.2017.17  1
2017 Chung J, Wittig JG, Ghamari A, Maeda M, Dailey TA, Bergonia H, Kafina MD, Coughlin EE, Minogue CE, Hebert AS, Li L, Kaplan J, Lodish HF, Bauer DE, Orkin SH, et al. Author response: Erythropoietin signaling regulates heme biosynthesis Elife. DOI: 10.7554/Elife.24767.018  1
2017 Ai S, Peng Y, Li C, Gu F, Yu X, Yue Y, Ma Q, Chen J, Lin Z, Zhou P, Xie H, Prendiville TW, Zheng W, Liu Y, Orkin SH, et al. Author response: EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent Elife. DOI: 10.7554/Elife.24570.023  0.64
2017 Sher F, Schoonenberg V, Cole MA, Macias-Trevino C, Cifani P, Schupp PG, Canver MC, Kurita R, Nakamura Y, Orkin S, Kentsis A, Pinello L, Maeda T, Bauer DE. High-Resolution CRISPR Functional Genomics Reveals Critical Vulnerabilities of the NuRD Complex for Fetal Hemoglobin Control Blood. 130: 286-286. DOI: 10.1182/Blood.V130.Suppl_1.286.286  0.48
2016 Beyaz S, Kim JH, Pinello L, Xifaras ME, Hu Y, Huang J, Kerenyi MA, Das PP, Barnitz RA, Herault A, Dogum R, Haining WN, Yilmaz ÖH, Passegue E, Yuan GC, ... Orkin SH, et al. The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells. Nature Immunology. PMID 27992400 DOI: 10.1038/Ni.3644  1
2016 Smith EC, Luc S, Croney DM, Woodworth MB, Greig LC, Fujiwara Y, Nguyen M, Sher F, Macklis JD, Bauer DE, Orkin SH. Strict in vivo specificity of the Bcl11a erythroid enhancer. Blood. PMID 27707736 DOI: 10.1182/Blood-2016-08-736249  1
2016 Nelms BD, Waldron L, Barrera LA, Weflen AW, Goettel JA, Guo G, Montgomery RK, Neutra MR, Breault DT, Snapper SB, Orkin SH, Bulyk ML, Huttenhower C, Lencer WI. CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types. Genome Biology. 17: 201. PMID 27687735 DOI: 10.1186/S13059-016-1062-5  0.44
2016 Luc S, Huang J, McEldoon JL, Somuncular E, Li D, Rhodes C, Mamoor S, Hou S, Xu J, Orkin SH. Bcl11a Deficiency Leads to Hematopoietic Stem Cell Defects with an Aging-like Phenotype. Cell Reports. 16: 3181-94. PMID 27653684 DOI: 10.1016/J.Celrep.2016.08.064  1
2016 Xie H, Peng C, Huang J, Li BE, Kim W, Smith EC, Fujiwara Y, Qi J, Cheloni G, Das PP, Nguyen M, Li S, Bradner JE, Orkin SH. Chronic myelogenous leukemia initiating cells require Polycomb group protein EZH2. Cancer Discovery. PMID 27630126 DOI: 10.1158/2159-8290.Cd-15-1439  1
2016 Brendel C, Guda S, Renella R, Bauer DE, Canver MC, Kim YJ, Heeney MM, Klatt D, Fogel J, Milsom MD, Orkin SH, Gregory RI, Williams DA. Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype. The Journal of Clinical Investigation. 126: 3868-3878. PMID 27599293 DOI: 10.1172/Jci87885  0.36
2016 Kim TH, Saadatpour A, Guo G, Saxena M, Cavazza A, Desai N, Jadhav U, Jiang L, Rivera MN, Orkin SH, Yuan GC, Shivdasani RA. Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells. Cell Reports. PMID 27524622 DOI: 10.1016/J.Celrep.2016.07.056  0.64
2016 Townsend EC, Murakami MA, Christodoulou A, Christie AL, Köster J, DeSouza TA, Morgan EA, Kallgren SP, Liu H, Wu SC, Plana O, Montero J, Stevenson KE, Rao P, Vadhi R, ... ... Orkin SH, et al. The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 30: 183. PMID 27479034 DOI: 10.1016/J.Ccell.2016.06.008  1
2016 Pinello L, Canver MC, Hoban MD, Orkin SH, Kohn DB, Bauer DE, Yuan GC. Analyzing CRISPR genome-editing experiments with CRISPResso. Nature Biotechnology. 34: 695-697. PMID 27404874 DOI: 10.1038/nbt.3583  0.64
2016 Shimizu T, Kubovcakova L, Nienhold R, Zmajkovic J, Meyer SC, Hao-Shen H, Geier F, Dirnhofer S, Guglielmelli P, Vannucchi AM, Feenstra JD, Kralovics R, Orkin SH, Skoda RC. Loss of Ezh2 synergizes with JAK2-V617F in initiating myeloproliferative neoplasms and promoting myelofibrosis. The Journal of Experimental Medicine. PMID 27401344 DOI: 10.1084/Jem.20151136  1
2016 Liddicoat BJ, Hartner JC, Piskol R, Ramaswami G, Chalk AM, Kingsley PD, Sankaran VG, Wall M, Purton LE, Seeburg PH, Palis J, Orkin SH, Lu J, Li JB, Walkley CR. Adenosine-to-insoine RNA editing by ADAR1 is essential for normal murine erythropoiesis. Experimental Hematology. PMID 27373493 DOI: 10.1016/J.Exphem.2016.06.250  0.32
2016 Mirzamohammadi F, Papaioannou G, Inloes JB, Rankin EB, Xie H, Schipani E, Orkin SH, Kobayashi T. Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling. Nature Communications. 7: 12047. PMID 27329220 DOI: 10.1038/Ncomms12047  0.48
2016 Jadhav U, Nalapareddy K, Saxena M, O'Neill NK, Pinello L, Yuan GC, Orkin SH, Shivdasani RA. Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells. Cell. PMID 27212235 DOI: 10.1016/J.Cell.2016.04.031  0.32
2016 Kim PG, Canver MC, Rhee C, Ross SJ, Harriss JV, Tu HC, Orkin SH, Tucker HO, Daley GQ. Interferon-alpha signaling promotes embryonic HSC maturation. Blood. PMID 27095787 DOI: 10.1182/Blood-2016-01-689281  1
2016 Kim J, Singh AK, Takata Y, Lin K, Shen J, Lu Y, Kerenyi MA, Orkin SH, Chen T. Corrigendum: LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice. Nature Communications. 7: 11467. PMID 27095451 DOI: 10.1038/Ncomms11467  1
2016 Townsend EC, Murakami MA, Christodoulou A, Christie AL, Köster J, DeSouza TA, Morgan EA, Kallgren SP, Liu H, Wu SC, Plana O, Montero J, Stevenson KE, Rao P, Vadhi R, ... ... Orkin SH, et al. The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 29: 574-86. PMID 27070704 DOI: 10.1016/J.Ccell.2016.03.008  1
2016 Canver MC, Orkin SH. Customizing the genome as therapy for the β-hemoglobinopathies. Blood. PMID 27053533 DOI: 10.1182/Blood-2016-01-678128  0.36
2016 Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour A, Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A, Arias E, Pinello L, Katz Y, Shinagare S, Abu-Remaileh M, Mihaylova MM, ... ... Orkin SH, et al. High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. 531: 53-8. PMID 26935695 DOI: 10.1038/Nature17173  0.64
2016 Danis E, Yamauchi T, Echanique K, Zhang X, Haladyna JN, Riedel SS, Zhu N, Xie H, Orkin SH, Armstrong SA, Bernt KM, Neff T. Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia. Cell Reports. PMID 26904942 DOI: 10.1016/J.Celrep.2016.01.064  0.44
2016 Orkin SH. Recent advances in globin research using genome-wide association studies and gene editing. Annals of the New York Academy of Sciences. PMID 26866328 DOI: 10.1111/Nyas.13001  1
2016 Masuda T, Wang X, Maeda M, Canver MC, Sher F, Funnell AP, Fisher C, Suciu M, Martyn GE, Norton LJ, Zhu C, Kurita R, Nakamura Y, Xu J, Higgs DR, ... ... Orkin SH, et al. Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin. Science (New York, N.Y.). 351: 285-9. PMID 26816381 DOI: 10.1126/Science.Aad3312  0.44
2016 Guo G, Pinello L, Han X, Lai S, Shen L, Lin TW, Zou K, Yuan GC, Orkin SH. Serum-Based Culture Conditions Provoke Gene Expression Variability in Mouse Embryonic Stem Cells as Revealed by Single-Cell Analysis. Cell Reports. PMID 26804902 DOI: 10.1016/J.Celrep.2015.12.089  1
2016 Huang J, Liu X, Li D, Shao Z, Cao H, Zhang Y, Trompouki E, Bowman TV, Zon LI, Yuan GC, Orkin SH, Xu J. Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis. Developmental Cell. 36: 9-23. PMID 26766440 DOI: 10.1016/J.Devcel.2015.12.014  1
2016 Serresi M, Gargiulo G, Proost N, Siteur B, Cesaroni M, Koppens M, Xie H, Sutherland K, Hulsman D, Citterio E, Orkin S, Berns A, Lohuizen Mv. Abstract IA05: Polycomb repressive complex-2 is a barrier to Kras-driven inflammation and epithelial-mesenchymal transition in non-small cell lung cancer Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Devbiolca15-Ia05  0.48
2016 Linn DE, Barros-Silva J, Guo G, Brown M, Ashton G, Clarke NW, Yuan G, Orkin SH, Baena E, Li Z. Abstract LB-275: Single cell analysis identified LY6D as a novel marker of castration-resistant multipotent luminal progenitors Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-275  0.56
2016 Serresi M, Gargiulo G, Proost N, Siteur B, Cesaroni M, Koppens M, Xie H, Sutherland KD, Hulsman D, Citterio E, Orkin S, Berns A, van Lohuizen M. Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer Cancer Cell. 29: 17-31. DOI: 10.1016/J.Ccell.2015.12.006  0.48
2015 De Los Angeles A, Ferrari F, Fujiwara Y, Mathieu R, Lee S, Lee S, Tu HC, Ross S, Chou S, Nguyen M, Wu Z, Theunissen TW, Powell BE, Imsoonthornruksa S, Chen J, ... ... Orkin SH, et al. Corrigendum: Failure to replicate the STAP cell phenomenon. Nature. PMID 26675720 DOI: 10.1038/Nature16479  1
2015 Yin J, Leavenworth JW, Li Y, Luo Q, Xie H, Liu X, Huang S, Yan H, Fu Z, Zhang LY, Zhang L, Hao J, Wu X, Deng X, Roberts CW, ... Orkin SH, et al. Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 26668377 DOI: 10.1073/Pnas.1521740112  0.44
2015 Kim J, Singh AK, Takata Y, Lin K, Shen J, Lu Y, Kerenyi MA, Orkin SH, Chen T. LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice. Nature Communications. 6: 10116. PMID 26626423 DOI: 10.1038/Ncomms10116  0.44
2015 Kim KH, Kim W, Howard TP, Vazquez F, Tsherniak A, Wu JN, Wang W, Haswell JR, Walensky LD, Hahn WC, Orkin SH, Roberts CW. SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2. Nature Medicine. PMID 26552009 DOI: 10.1038/Nm.3968  0.44
2015 Miles WO, Lepesant JM, Bourdeaux J, Texier M, Kerenyi MA, Nakakido M, Hamamoto R, Orkin SH, Dyson NJ, Di Stefano L. The LSD1 family of histone demethylases and the PUMILIO post-transcriptional repressor function in a complex regulatory feedback loop. Molecular and Cellular Biology. PMID 26438601 DOI: 10.1128/Mcb.00755-15  0.44
2015 De Los Angeles A, Ferrari F, Fujiwara Y, Mathieu R, Lee S, Lee S, Tu HC, Ross S, Chou S, Nguyen M, Wu Z, Theunissen TW, Powell BE, Imsoonthornruksa S, Chen J, ... ... Orkin SH, et al. Failure to replicate the STAP cell phenomenon. Nature. 525: E6-9. PMID 26399835 DOI: 10.1038/Nature15513  1
2015 Anderson H, Patch TC, Reddy PN, Hagedorn EJ, Kim PG, Soltis KA, Chen MJ, Tamplin OJ, Frye M, MacLean GA, Hübner K, Bauer DE, Kanki JP, Vogin G, Huston NC, ... ... Orkin SH, et al. Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression. Blood. PMID 26385351 DOI: 10.1182/Blood-2015-07-659276  0.44
2015 Bauer DE, Orkin SH. Hemoglobin switching's surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin. Current Opinion in Genetics & Development. 33: 62-70. PMID 26375765 DOI: 10.1016/J.Gde.2015.08.001  1
2015 Canver MC, Smith EC, Sher F, Pinello L, Sanjana NE, Shalem O, Chen DD, Schupp PG, Vinjamur DS, Garcia SP, Luc S, Kurita R, Nakamura Y, Fujiwara Y, Maeda T, ... ... Orkin SH, et al. BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis. Nature. PMID 26375006 DOI: 10.1038/Nature15521  1
2015 Vierstra J, Reik A, Chang KH, Stehling-Sun S, Zhou Y, Hinkley SJ, Paschon DE, Zhang L, Psatha N, Bendana YR, O'Neil CM, Song AH, Mich AK, Liu PQ, Lee G, ... ... Orkin SH, et al. Functional footprinting of regulatory DNA. Nature Methods. PMID 26322838 DOI: 10.1038/Nmeth.3554  0.44
2015 Renneville A, Van Galen P, Canver MC, McConkey M, Krill-Burger JM, Dorfman DM, Holson EB, Bernstein BE, Orkin SH, Bauer DE, Ebert BL. EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression. Blood. 126: 1930-9. PMID 26320100 DOI: 10.1182/Blood-2015-06-649087  0.44
2015 Das PP, Hendrix DA, Apostolou E, Buchner AH, Canver MC, Beyaz S, Ljuboja D, Kuintzle R, Kim W, Karnik R, Shao Z, Xie H, Xu J, De Los Angeles A, Zhang Y, ... ... Orkin SH, et al. PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells. Cell Reports. 12: 1456-1470. PMID 26299972 DOI: 10.1016/J.Celrep.2015.07.053  1
2015 Danis E, Yamauchi T, Echanique K, Haladyna J, Kalkur R, Riedel S, Zhu N, Xie H, Bernt KM, Orkin SH, Armstrong SA, Neff T. Inactivation of Eed Impedes MLL-AF9 Mediated Leukemogenesis Through Cdkn2a-Dependent and Cdkn2a-Independent Mechanisms in a Murine Model. Experimental Hematology. PMID 26118502 DOI: 10.1016/J.Exphem.2015.06.005  0.44
2015 Guda S, Brendel C, Renella R, Du P, Bauer DE, Canver MC, Grenier JK, Grimson AW, Kamran SC, Thornton J, de Boer H, Root DE, Milsom MD, Orkin SH, Gregory RI, et al. miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 1465-74. PMID 26080908 DOI: 10.1038/Mt.2015.113  0.36
2015 Ma KH, Hung HA, Srinivasan R, Xie H, Orkin SH, Svaren J. Regulation of Peripheral Nerve Myelin Maintenance by Gene Repression through Polycomb Repressive Complex 2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 8640-52. PMID 26041929 DOI: 10.1523/Jneurosci.2257-14.2015  0.48
2015 Canver MC, Bauer DE, Orkin SH. Embryonic stem cells as sources of donor-independent platelets. The Journal of Clinical Investigation. 125: 2261-3. PMID 25961451 DOI: 10.1172/Jci82348  1
2015 Basak A, Hancarova M, Ulirsch JC, Balci TB, Trkova M, Pelisek M, Vlckova M, Muzikova K, Cermak J, Trka J, Dyment DA, Orkin SH, Daly MJ, Sedlacek Z, Sankaran VG. BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations. The Journal of Clinical Investigation. 125: 2363-8. PMID 25938782 DOI: 10.1172/Jci81163  0.64
2015 Yin Y, Yan P, Lu J, Song G, Zhu Y, Li Z, Zhao Y, Shen B, Huang X, Zhu H, Orkin SH, Shen X. Opposing Roles for the lncRNA Haunt and Its Genomic Locus in Regulating HOXA Gene Activation during Embryonic Stem Cell Differentiation. Cell Stem Cell. 16: 504-16. PMID 25891907 DOI: 10.1016/J.Stem.2015.03.007  0.68
2015 Chung J, Bauer DE, Ghamari A, Nizzi CP, Deck KM, Kingsley PD, Yien YY, Huston NC, Chen C, Schultz IJ, Dalton AJ, Wittig JG, Palis J, Orkin SH, Lodish HF, et al. The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability. Science Signaling. 8: ra34. PMID 25872869 DOI: 10.1126/Scisignal.Aaa5903  1
2015 Kim PG, Nakano H, Das PP, Chen MJ, Rowe RG, Chou SS, Ross SJ, Sakamoto KM, Zon LI, Schlaeger TM, Orkin SH, Nakano A, Daley GQ. Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence. The Journal of Experimental Medicine. 212: 633-48. PMID 25870201 DOI: 10.1084/Jem.20141514  1
2015 Orkin SH. 2014 William Allan Award: A hematologist's pursuit of hemoglobin genetics. American Journal of Human Genetics. 96: 354-60. PMID 25748351 DOI: 10.1016/J.Ajhg.2014.12.007  1
2015 Lin MI, Price EN, Boatman S, Hagedorn EJ, Trompouki E, Satishchandran S, Carspecken CW, Uong A, DiBiase A, Yang S, Canver MC, Dahlberg A, Lu Z, Zhang CC, Orkin SH, et al. Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling. Elife. 4. PMID 25714926 DOI: 10.7554/Elife.05544  1
2015 Maier VK, Feeney CM, Taylor JE, Creech AL, Qiao JW, Szanto A, Das PP, Chevrier N, Cifuentes-Rojas C, Orkin SH, Carr SA, Jaffe JD, Mertins P, Lee JT. Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator. Molecular & Cellular Proteomics : McP. 14: 1435-46. PMID 25680957 DOI: 10.1074/Mcp.M114.044586  1
2015 Xu J, Shao Z, Li D, Xie H, Kim W, Huang J, Taylor JE, Pinello L, Glass K, Jaffe JD, Yuan GC, Orkin SH. Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions. Molecular Cell. 57: 304-16. PMID 25578878 DOI: 10.1016/J.Molcel.2014.12.009  1
2015 Org T, Duan D, Ferrari R, Montel-Hagen A, Van Handel B, Kerényi MA, Sasidharan R, Rubbi L, Fujiwara Y, Pellegrini M, Orkin SH, Kurdistani SK, Mikkola HK. Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence. The Embo Journal. 34: 759-77. PMID 25564442 DOI: 10.15252/Embj.201490542  1
2015 Bauer DE, Canver MC, Orkin SH. Generation of genomic deletions in mammalian cell lines via CRISPR/Cas9. Journal of Visualized Experiments : Jove. PMID 25549070 DOI: 10.3791/52118  0.36
2015 Lin MI, Price EN, Boatman S, Hagedorn EJ, Trompouki E, Satishchandran S, Carspecken CW, Uong A, DiBiase A, Yang S, Canver MC, Dahlberg A, Lu Z, Zhang CC, Orkin SH, et al. Author response: Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling Elife. DOI: 10.7554/Elife.05544.021  1
2015 Bauer DE, Canver MC, Smith EC, Sher F, Pinello L, Sanjana NE, Shalem O, Chen DD, Schupp PG, Vinjamur DS, Garcia SP, Luc S, Kurita R, Nakamura Y, Fujiwara Y, ... ... Orkin SH, et al. Crispr-Cas9 Saturating Mutagenesis Reveals an Achilles Heel in the BCL11A Erythroid Enhancer for Fetal Hemoglobin Induction (by Genome Editing) Blood. 126: 638-638. DOI: 10.1182/Blood.V126.23.638.638  1
2015 Masuda T, Wang X, Maeda M, Canver MC, Sher F, Funnell APW, Fisher C, Suciu M, Martyn GE, Norton LJ, Zhu R, Kurita R, Nakamura Y, Xu J, Higgs DR, ... ... Orkin SH, et al. The LRF/ZBTB7A Transcription Factor Is a BCL11A-Independent Repressor of Fetal Hemoglobin Blood. 126: 2-2. DOI: 10.1182/Blood.V126.23.2.2  0.76
2014 Saadatpour A, Guo G, Orkin SH, Yuan GC. Characterizing heterogeneity in leukemic cells using single-cell gene expression analysis. Genome Biology. 15: 525. PMID 25517911 DOI: 10.1186/S13059-014-0525-9  1
2014 Perry JA, Kiezun A, Tonzi P, Van Allen EM, Carter SL, Baca SC, Cowley GS, Bhatt AS, Rheinbay E, Pedamallu CS, Helman E, Taylor-Weiner A, McKenna A, DeLuca DS, Lawrence MS, ... ... Orkin SH, et al. Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma. Proceedings of the National Academy of Sciences of the United States of America. 111: E5564-73. PMID 25512523 DOI: 10.1073/Pnas.1419260111  1
2014 Vierstra J, Rynes E, Sandstrom R, Zhang M, Canfield T, Hansen RS, Stehling-Sun S, Sabo PJ, Byron R, Humbert R, Thurman RE, Johnson AK, Vong S, Lee K, Bates D, ... ... Orkin SH, et al. Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution. Science (New York, N.Y.). 346: 1007-12. PMID 25411453 DOI: 10.1126/Science.1246426  1
2014 Li Y, Esain V, Teng L, Xu J, Kwan W, Frost IM, Yzaguirre AD, Cai X, Cortes M, Maijenburg MW, Tober J, Dzierzak E, Orkin SH, Tan K, North TE, et al. Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production. Genes & Development. 28: 2597-612. PMID 25395663 DOI: 10.1101/Gad.253302.114  1
2014 Lundberg P, Takizawa H, Kubovcakova L, Guo G, Hao-Shen H, Dirnhofer S, Orkin SH, Manz MG, Skoda RC. Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F. The Journal of Experimental Medicine. 211: 2213-30. PMID 25288396 DOI: 10.1084/Jem.20131371  1
2014 Yien YY, Robledo RF, Schultz IJ, Takahashi-Makise N, Gwynn B, Bauer DE, Dass A, Yi G, Li L, Hildick-Smith GJ, Cooney JD, Pierce EL, Mohler K, Dailey TA, Miyata N, ... ... Orkin SH, et al. TMEM14C is required for erythroid mitochondrial heme metabolism. The Journal of Clinical Investigation. 124: 4294-304. PMID 25157825 DOI: 10.1172/Jci76979  1
2014 Canver MC, Bauer DE, Dass A, Yien YY, Chung J, Masuda T, Maeda T, Paw BH, Orkin SH. Characterization of genomic deletion efficiency mediated by clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells. The Journal of Biological Chemistry. 289: 21312-24. PMID 24907273 DOI: 10.1074/Jbc.M114.564625  1
2014 Riddell J, Gazit R, Garrison BS, Guo G, Saadatpour A, Mandal PK, Ebina W, Volchkov P, Yuan GC, Orkin SH, Rossi DJ. Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors. Cell. 157: 549-64. PMID 24766805 DOI: 10.1016/J.Cell.2014.04.006  1
2014 Foudi A, Kramer DJ, Qin J, Ye D, Behlich AS, Mordecai S, Preffer FI, Amzallag A, Ramaswamy S, Hochedlinger K, Orkin SH, Hock H. Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation. The Journal of Experimental Medicine. 211: 909-27. PMID 24711581 DOI: 10.1084/Jem.20131065  1
2014 Yao H, Goldman DC, Nechiporuk T, Kawane S, McWeeney SK, Tyner JW, Fan G, Kerenyi MA, Orkin SH, Fleming WH, Mandel G. Corepressor Rcor1 is essential for murine erythropoiesis. Blood. 123: 3175-84. PMID 24652990 DOI: 10.1182/Blood-2013-11-538678  1
2014 Pinello L, Xu J, Orkin SH, Yuan GC. Analysis of chromatin-state plasticity identifies cell-type-specific regulators of H3K27me3 patterns. Proceedings of the National Academy of Sciences of the United States of America. 111: E344-53. PMID 24395799 DOI: 10.1073/Pnas.1322570111  1
2014 Das PP, Shao Z, Beyaz S, Apostolou E, Pinello L, De Los Angeles A, O'Brien K, Atsma JM, Fujiwara Y, Nguyen M, Ljuboja D, Guo G, Woo A, Yuan GC, Onder T, ... ... Orkin SH, et al. Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity. Molecular Cell. 53: 32-48. PMID 24361252 DOI: 10.1016/J.Molcel.2013.11.011  1
2014 Maroz A, Stachorski L, Emmrich S, Reinhardt K, Xu J, Shao Z, Käbler S, Dertmann T, Hitzler J, Roberts I, Vyas P, Juban G, Hennig C, Hansen G, Li Z, ... Orkin S, et al. GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia. Leukemia. 28: 1259-70. PMID 24336126 DOI: 10.1038/Leu.2013.373  1
2014 Xie H, Xu J, Hsu JH, Nguyen M, Fujiwara Y, Peng C, Orkin SH. Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner. Cell Stem Cell. 14: 68-80. PMID 24239285 DOI: 10.1016/J.Stem.2013.10.001  1
2014 Stankov MV, El Khatib M, Kumar Thakur B, Heitmann K, Panayotova-Dimitrova D, Schoening J, Bourquin JP, Schweitzer N, Leverkus M, Welte K, Reinhardt D, Li Z, Orkin SH, Behrens GM, Klusmann JH. Histone deacetylase inhibitors induce apoptosis in myeloid leukemia by suppressing autophagy. Leukemia. 28: 577-88. PMID 24080946 DOI: 10.1038/Leu.2013.264  1
2014 Ghamari A, Jaensch E, Giadone R, Akie TE, Xu J, Bauer D, Orkin SH, Cantor AB. An SCF-FBXW7 Ubiquitin Ligase Mediated Feedback Loop Facilitates GATA Factor Switching and Reinforces Commitment to Terminal Erythroid Maturation Blood. 124: 245-245. DOI: 10.1182/Blood.V124.21.245.245  0.48
2014 Xu J, Shao Z, Li D, Xie H, Kim W, Huang J, Pinello L, Glass K, Yuan G, Orkin SH. Developmental Control of Polycomb Subunit Composition Mediates a Switch to Non-Canonical Functions during Hematopoiesis Blood. 124: 241-241. DOI: 10.1182/Blood.V124.21.241.241  1
2014 Shimizu T, Hao-Shen H, Kubovcakova L, Lundberg P, Dirnhofer S, Orkin SH, Grisouard J, Shimizu Y, Pianta A, Szczerba B, Nienhold R, Skoda RC. JAK2V617F and Loss of Ezh2 in Hematopoietic Cells Contribute Synergistically to Myeloproliferative Neoplasm Initiation Potential, and Accelerate Progression of Disease Blood. 124: 158-158. DOI: 10.1182/Blood.V124.21.158.158  1
2013 Elagib KE, Rubinstein JD, Delehanty LL, Ngoh VS, Greer PA, Li S, Lee JK, Li Z, Orkin SH, Mihaylov IS, Goldfarb AN. Calpain 2 activation of P-TEFb drives megakaryocyte morphogenesis and is disrupted by leukemogenic GATA1 mutation. Developmental Cell. 27: 607-20. PMID 24369834 DOI: 10.1016/J.Devcel.2013.11.013  1
2013 Bauer DE, Kamran SC, Lessard S, Xu J, Fujiwara Y, Lin C, Shao Z, Canver MC, Smith EC, Pinello L, Sabo PJ, Vierstra J, Voit RA, Yuan GC, Porteus MH, ... ... Orkin SH, et al. An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. Science (New York, N.Y.). 342: 253-7. PMID 24115442 DOI: 10.1126/Science.1242088  1
2013 Guo G, Luc S, Marco E, Lin TW, Peng C, Kerenyi MA, Beyaz S, Kim W, Xu J, Das PP, Neff T, Zou K, Yuan GC, Orkin SH. Mapping cellular hierarchy by single-cell analysis of the cell surface repertoire. Cell Stem Cell. 13: 492-505. PMID 24035353 DOI: 10.1016/J.Stem.2013.07.017  1
2013 Kim W, Bird GH, Neff T, Guo G, Kerenyi MA, Walensky LD, Orkin SH. Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nature Chemical Biology. 9: 643-50. PMID 23974116 DOI: 10.1038/Nchembio.1331  1
2013 Luc S, Orkin SH. Delineating the mixed lineage leukemia gene expression network in hematopoietic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 11670-1. PMID 23824294 DOI: 10.1073/Pnas.1310349110  1
2013 Kerenyi MA, Shao Z, Hsu YJ, Guo G, Luc S, O'Brien K, Fujiwara Y, Peng C, Nguyen M, Orkin SH. Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation. Elife. 2: e00633. PMID 23795291 DOI: 10.7554/Elife.00633  1
2013 Xu J, Bauer DE, Kerenyi MA, Vo TD, Hou S, Hsu YJ, Yao H, Trowbridge JJ, Mandel G, Orkin SH. Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A. Proceedings of the National Academy of Sciences of the United States of America. 110: 6518-23. PMID 23576758 DOI: 10.1073/Pnas.1303976110  1
2013 Baena E, Shao Z, Linn DE, Glass K, Hamblen MJ, Fujiwara Y, Kim J, Nguyen M, Zhang X, Godinho FJ, Bronson RT, Mucci LA, Loda M, Yuan GC, Orkin SH, et al. ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients. Genes & Development. 27: 683-98. PMID 23512661 DOI: 10.1101/Gad.211011.112  1
2013 Sankaran VG, Orkin SH. Genome-wide association studies of hematologic phenotypes: A window into human hematopoiesis Current Opinion in Genetics and Development. 23: 339-344. PMID 23477921 DOI: 10.1016/J.Gde.2013.02.006  1
2013 Sankaran VG, Orkin SH. The switch from fetal to adult hemoglobin Cold Spring Harbor Perspectives in Medicine. 3. PMID 23209159 DOI: 10.1101/Cshperspect.A011643  1
2013 Bai X, Trowbridge JJ, Riley E, Lee JA, DiBiase A, Kaartinen VM, Orkin SH, Zon LI. TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes. Developmental Biology. 373: 422-30. PMID 23159334 DOI: 10.1016/J.Ydbio.2012.10.008  1
2013 Kerenyi MA, Shao Z, Hsu Y, Guo G, Luc S, O'Brien K, Fujiwara Y, Peng C, Nguyen M, Orkin SH. Author response: Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation Elife. DOI: 10.7554/Elife.00633.024  1
2013 Liddicoat B, Hartner J, Chalk A, Lu J, Orkin SH, Walkley CR. ADAR1 Is Essential For Erythroid Development Blood. 122: 9-9. DOI: 10.1182/Blood.V122.21.9.9  0.44
2013 Baena E, Shao Z, Linn D, Glass K, Hamblen M, Fujiwara Y, Kim J, Nguyen M, Zhang X, Godinho F, Bronson RT, Mucci L, Loda M, Yuan G, Li Z, ... Orkin SH, et al. Abstract 5393: ETV1 directs androgen metabolism and confers aggressive prostate cancer in engineered mice and patients. Cancer Research. 73: 5393-5393. DOI: 10.1158/1538-7445.Am2013-5393  1
2013 Kim W, Bird GH, Neff T, Guo G, Kerenyi MA, Walensky LD, Orkin SH. Abstract B254: Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-B254  0.6
2013 Baena E, Mamoor S, Li Z, Orkin SH. Abstract B157: Understanding the role of transcription factor ETV1 in metabolic reprogramming of prostate cells as a route to novel therapeutics. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-B157  0.56
2012 Maclean GA, Menne TF, Guo G, Sanchez DJ, Park IH, Daley GQ, Orkin SH. Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 17567-72. PMID 23045682 DOI: 10.1182/Blood.V118.21.921.921  1
2012 Xu J, Shao Z, Glass K, Bauer DE, Pinello L, Van Handel B, Hou S, Stamatoyannopoulos JA, Mikkola HK, Yuan GC, Orkin SH. Combinatorial assembly of developmental stage-specific enhancers controls gene expression programs during human erythropoiesis. Developmental Cell. 23: 796-811. PMID 23041383 DOI: 10.1016/J.Devcel.2012.09.003  1
2012 Sankaran VG, Ludwig LS, Sicinska E, Xu J, Bauer DE, Eng JC, Patterson HC, Metcalf RA, Natkunam Y, Orkin SH, Sicinski P, Lander ES, Lodish HF. Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number. Genes & Development. 26: 2075-87. PMID 22929040 DOI: 10.1101/Gad.197020.112  1
2012 Bauer DE, Kamran SC, Orkin SH. Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders. Blood. 120: 2945-53. PMID 22904296 DOI: 10.1182/Blood-2012-06-292078  1
2012 Van Handel B, Montel-Hagen A, Sasidharan R, Nakano H, Ferrari R, Boogerd CJ, Schredelseker J, Wang Y, Hunter S, Org T, Zhou J, Li X, Pellegrini M, Chen JN, Orkin SH, et al. Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell. 150: 590-605. PMID 22863011 DOI: 10.1016/J.Cell.2012.06.026  1
2012 Funnell AP, Norton LJ, Mak KS, Burdach J, Artuz CM, Twine NA, Wilkins MR, Power CA, Hung TT, Perdomo J, Koh P, Bell-Anderson KS, Orkin SH, Fraser ST, Perkins AC, et al. The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo. Molecular and Cellular Biology. 32: 3281-92. PMID 22711990 DOI: 10.1128/Mcb.00173-12  1
2012 Sankaran VG, Ghazvinian R, Do R, Thiru P, Vergilio JA, Beggs AH, Sieff CA, Orkin SH, Nathan DG, Lander ES, Gazda HT. Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia. The Journal of Clinical Investigation. 122: 2439-43. PMID 22706301 DOI: 10.1172/Jci63597  1
2012 Shao Z, Zhang Y, Yuan GC, Orkin SH, Waxman DJ. MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets. Genome Biology. 13: R16. PMID 22424423 DOI: 10.1186/Gb-2012-13-3-R16  1
2012 Neff T, Sinha AU, Kluk MJ, Zhu N, Khattab MH, Stein L, Xie H, Orkin SH, Armstrong SA. Polycomb repressive complex 2 is required for MLL-AF9 leukemia. Proceedings of the National Academy of Sciences of the United States of America. 109: 5028-33. PMID 22396593 DOI: 10.1073/Pnas.1202258109  1
2012 Parikh VN, Jin RC, Rabello S, Gulbahce N, White K, Hale A, Cottrill KA, Shaik RS, Waxman AB, Zhang YY, Maron BA, Hartner JC, Fujiwara Y, Orkin SH, Haley KJ, et al. MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach. Circulation. 125: 1520-32. PMID 22371328 DOI: 10.1161/Circulationaha.111.060269  1
2012 Trowbridge JJ, Sinha AU, Zhu N, Li M, Armstrong SA, Orkin SH. Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. Genes & Development. 26: 344-9. PMID 22345515 DOI: 10.1182/Blood.V118.21.3459.3459  1
2012 Chau BN, Xin C, Hartner J, Ren S, Castano AP, Linn G, Li J, Tran PT, Kaimal V, Huang X, Chang AN, Li S, Kalra A, Grafals M, Portilla D, ... ... Orkin SH, et al. MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways. Science Translational Medicine. 4: 121ra18. PMID 22344686 DOI: 10.1126/Scitranslmed.3003205  1
2012 Shi Y, Kirwan P, Smith J, MacLean G, Orkin SH, Livesey FJ. A human stem cell model of early Alzheimer's disease pathology in Down syndrome. Science Translational Medicine. 4: 124ra29. PMID 22344463 DOI: 10.1126/Scitranslmed.3003771  1
2012 He A, Shen X, Ma Q, Cao J, von Gise A, Zhou P, Wang G, Marquez VE, Orkin SH, Pu WT. PRC2 directly methylates GATA4 and represses its transcriptional activity. Genes & Development. 26: 37-42. PMID 22215809 DOI: 10.1101/Gad.173930.111  0.68
2012 Trowbridge JJ, Orkin SH. Dnmt3a silences hematopoietic stem cell self-renewal. Nature Genetics. 44: 13-4. PMID 22200773 DOI: 10.1038/Ng.1043  1
2012 He A, Ma Q, Cao J, von Gise A, Zhou P, Xie H, Zhang B, Hsing M, Christodoulou DC, Cahan P, Daley GQ, Kong SW, Orkin SH, Seidman CE, Seidman JG, et al. Polycomb repressive complex 2 regulates normal development of the mouse heart. Circulation Research. 110: 406-15. PMID 22158708 DOI: 10.1161/Circresaha.111.252205  1
2012 Basu-Roy U, Seo E, Ramanathapuram L, Rapp TB, Perry JA, Orkin SH, Mansukhani A, Basilico C. Sox2 maintains self renewal of tumor-initiating cells in osteosarcomas. Oncogene. 31: 2270-82. PMID 21927024 DOI: 10.1038/Onc.2011.405  1
2012 Trowbridge JJ, Li M, Roberts CWM, Orkin SH. Genetic or Pharmacological Reductions in DNA Methylation Selectively Inhibit Peripheral T-Cell Lymphomagenesis. Blood. 120: 2760-2760. DOI: 10.1182/Blood.V120.21.2760.2760  1
2012 Koch ML, Zhang X, Hamblen M, Godinho F, Reinhardt D, Klusmann J, Orkin SH, Li Z. Reduced Erg Dosage Perturbs Fetal and Adult Hematopoiesis Blood. 120: 1189-1189. DOI: 10.1182/Blood.V120.21.1189.1189  0.56
2012 Baena E, Shao Z, Linn D, Hamblen M, Glass K, Saumyadipta P, Fujiwara Y, Godinho F, Kim J, Al-Shhrour F, Nguyen M, Yuan G, Bronson RT, Loda M, Orkin SH, et al. Abstract 2965: ERG and ETV1 regulate a common transcriptional network in prostate cells but in an opposite fashion Cancer Research. 72: 2965-2965. DOI: 10.1158/1538-7445.Am2012-2965  1
2011 Kim J, Orkin SH. Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine. Genome Medicine. 3: 75. PMID 22126538 DOI: 10.1186/Gm291  1
2011 Xu J, Peng C, Sankaran VG, Shao Z, Esrick EB, Chong BG, Ippolito GC, Fujiwara Y, Ebert BL, Tucker PW, Orkin SH. Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. Science (New York, N.Y.). 334: 993-6. PMID 21998251 DOI: 10.1126/Science.1211053  1
2011 Fidalgo M, Shekar PC, Ang YS, Fujiwara Y, Orkin SH, Wang J. Zfp281 functions as a transcriptional repressor for pluripotency of mouse embryonic stem cells. Stem Cells (Dayton, Ohio). 29: 1705-16. PMID 21915945 DOI: 10.1002/Stem.736  1
2011 Sankaran VG, Xu J, Byron R, Greisman HA, Fisher C, Weatherall DJ, Sabath DE, Groudine M, Orkin SH, Premawardhena A, Bender MA. A functional element necessary for fetal hemoglobin silencing. The New England Journal of Medicine. 365: 807-14. PMID 21879898 DOI: 10.1056/Nejmoa1103070  1
2011 Lu TX, Hartner J, Lim EJ, Fabry V, Mingler MK, Cole ET, Orkin SH, Aronow BJ, Rothenberg ME. MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity. Journal of Immunology (Baltimore, Md. : 1950). 187: 3362-73. PMID 21849676 DOI: 10.4049/Jimmunol.1101235  1
2011 Lin W, Cao J, Liu J, Beshiri ML, Fujiwara Y, Francis J, Cherniack AD, Geisen C, Blair LP, Zou MR, Shen X, Kawamori D, Liu Z, Grisanzio C, Watanabe H, ... ... Orkin SH, et al. Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proceedings of the National Academy of Sciences of the United States of America. 108: 13379-86. PMID 21788502 DOI: 10.1073/Pnas.1110104108  1
2011 Orkin SH, Hochedlinger K. Chromatin connections to pluripotency and cellular reprogramming. Cell. 145: 835-50. PMID 21663790 DOI: 10.1016/J.Cell.2011.05.019  1
2011 Orkin SH. Genome Medicine: stem cells, genomics and translational research. Genome Medicine. 3: 34. PMID 21658298 DOI: 10.1186/Gm250  1
2011 Xu J, Orkin SH. The erythroid/myeloid lineage fate paradigm takes a new player. The Embo Journal. 30: 983-5. PMID 21407249 DOI: 10.1038/Emboj.2011.45  1
2011 Snow JW, Trowbridge JJ, Johnson KD, Fujiwara T, Emambokus NE, Grass JA, Orkin SH, Bresnick EH. Context-dependent function of "GATA switch" sites in vivo. Blood. 117: 4769-72. PMID 21398579 DOI: 10.1182/Blood-2010-10-313031  1
2011 Koh KP, Yabuuchi A, Rao S, Huang Y, Cunniff K, Nardone J, Laiho A, Tahiliani M, Sommer CA, Mostoslavsky G, Lahesmaa R, Orkin SH, Rodig SJ, Daley GQ, Rao A. Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell. 8: 200-13. PMID 21295276 DOI: 10.1016/J.Stem.2011.01.008  1
2011 Sankaran VG, Menne TF, Šćepanović D, Vergilio JA, Ji P, Kim J, Thiru P, Orkin SH, Lander ES, Lodish HF. MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. Proceedings of the National Academy of Sciences of the United States of America. 108: 1519-24. PMID 21205891 DOI: 10.1073/Pnas.1018384108  1
2011 Bauer DE, Orkin SH. Update on fetal hemoglobin gene regulation in hemoglobinopathies. Current Opinion in Pediatrics. 23: 1-8. PMID 21157349 DOI: 10.1097/Mop.0B013E3283420Fd0  1
2011 Wilber A, Hargrove PW, Kim YS, Riberdy JM, Sankaran VG, Papanikolaou E, Georgomanoli M, Anagnou NP, Orkin SH, Nienhuis AW, Persons DA. Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer. Blood. 117: 2817-26. PMID 21156846 DOI: 10.1182/Blood-2010-08-300723  1
2011 Kerenyi MA, Hsu J, Shao Z, Orkin SH. Histone Demethylase LSD1 Is Required to Repress Hematopoietic Stem Cell Signatures in Mature Blood Cells to Permit Terminal Differentiation Blood. 118: 550-550. DOI: 10.1182/Blood.V118.21.550.550  0.48
2011 Stankov MV, Heitmann K, Li Z, Thakur BK, Panayotova-Dimitrova D, Schöning J, Bourquin J, Dittrich T, Emmrich S, Schweitzer N, Leverkus M, Reinhardt D, Orkin SH, Behrens GMN, Klusmann J. mTOR Pathway Links Suppressed Autophagy to HDAC Inhibitor-Induced Apoptosis in Myeloid Leukemia, Blood. 118: 3614-3614. DOI: 10.1182/Blood.V118.21.3614.3614  0.56
2011 Bragt Mv, Godinho F, Orkin S, Li Z. Abstract LB-35: ETV6-NTRK3 basal-like breast cancers originating from Wap+ breast cells progress through a premalignant stage enriched in luminal progenitors Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-35  0.56
2010 Bjork BC, Fujiwara Y, Davis SW, Qiu H, Saunders TL, Sandy P, Orkin S, Camper SA, Beier DR. A transient transgenic RNAi strategy for rapid characterization of gene function during embryonic development. Plos One. 5: e14375. PMID 21179568 DOI: 10.1371/Journal.Pone.0014375  1
2010 Kerenyi MA, Orkin SH. Networking erythropoiesis. The Journal of Experimental Medicine. 207: 2537-41. PMID 21098097 DOI: 10.1084/jem.20102260  1
2010 Galarneau G, Palmer CD, Sankaran VG, Orkin SH, Hirschhorn JN, Lettre G. Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation Nature Genetics. 42: 1049-1051. PMID 21057501 DOI: 10.1038/Ng.707  1
2010 Sankaran VG, Lettre G, Orkin SH, Hirschhorn JN. Modifier genes in Mendelian disorders: the example of hemoglobin disorders. Annals of the New York Academy of Sciences. 1214: 47-56. PMID 21039591 DOI: 10.1111/J.1749-6632.2010.05821.X  1
2010 Wilson BG, Wang X, Shen X, McKenna ES, Lemieux ME, Cho YJ, Koellhoffer EC, Pomeroy SL, Orkin SH, Roberts CW. Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation. Cancer Cell. 18: 316-28. PMID 20951942 DOI: 10.1016/J.Ccr.2010.09.006  1
2010 Kim J, Woo AJ, Chu J, Snow JW, Fujiwara Y, Kim CG, Cantor AB, Orkin SH. A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell. 143: 313-24. PMID 20946988 DOI: 10.1016/J.Cell.2010.09.010  1
2010 Snow JW, Trowbridge JJ, Fujiwara T, Emambokus NE, Grass JA, Orkin SH, Bresnick EH. A single cis element maintains repression of the key developmental regulator Gata2. Plos Genetics. 6: e1001103. PMID 20838598 DOI: 10.1371/Journal.Pgen.1001103  1
2010 Rao S, Zhen S, Roumiantsev S, McDonald LT, Yuan GC, Orkin SH. Differential roles of Sall4 isoforms in embryonic stem cell pluripotency. Molecular and Cellular Biology. 30: 5364-80. PMID 20837710 DOI: 10.1128/Mcb.00419-10  0.64
2010 Sankaran VG, Xu J, Orkin SH. Transcriptional silencing of fetal hemoglobin by BCL11A. Annals of the New York Academy of Sciences. 1202: 64-8. PMID 20712774 DOI: 10.1111/J.1749-6632.2010.05574.X  1
2010 Klusmann JH, Godinho FJ, Heitmann K, Maroz A, Koch ML, Reinhardt D, Orkin SH, Li Z. Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis. Genes & Development. 24: 1659-72. PMID 20679399 DOI: 10.1101/Gad.1903410  0.56
2010 Orkin SH, Higgs DR. Medicine. Sickle cell disease at 100 years. Science (New York, N.Y.). 329: 291-2. PMID 20647458 DOI: 10.1126/Science.1194035  1
2010 Kim K, Doi A, Wen B, Ng K, Zhao R, Cahan P, Kim J, Aryee MJ, Ji H, Ehrlich LI, Yabuuchi A, Takeuchi A, Cunniff KC, Hongguang H, McKinney-Freeman S, ... ... Orkin SH, et al. Epigenetic memory in induced pluripotent stem cells. Nature. 467: 285-90. PMID 20644535 DOI: 10.1038/Nature09342  1
2010 Bai X, Kim J, Yang Z, Jurynec MJ, Akie TE, Lee J, LeBlanc J, Sessa A, Jiang H, DiBiase A, Zhou Y, Grunwald DJ, Lin S, Cantor AB, Orkin SH, et al. TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell. 142: 133-43. PMID 20603019 DOI: 10.1016/J.Cell.2010.05.028  1
2010 Snow JW, Kim J, Currie CR, Xu J, Orkin SH. Sumoylation regulates interaction of FOG1 with C-terminal-binding protein (CTBP). The Journal of Biological Chemistry. 285: 28064-75. PMID 20587419 DOI: 10.1074/Jbc.M109.096909  1
2010 Xu J, Sankaran VG, Ni M, Menne TF, Puram RV, Kim W, Orkin SH. Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6. Genes & Development. 24: 783-98. PMID 20395365 DOI: 10.1101/Gad.1897310  1
2010 Trowbridge JJ, Orkin SH. DNA methylation in adult stem cells: new insights into self-renewal. Epigenetics : Official Journal of the Dna Methylation Society. 5: 189-93. PMID 20364115 DOI: 10.4161/Epi.5.3.11374  1
2010 Sankaran VG, Xu J, Orkin SH. Advances in the understanding of haemoglobin switching. British Journal of Haematology. 149: 181-94. PMID 20201948 DOI: 10.1111/J.1365-2141.2010.08105.X  1
2010 Klusmann JH, Li Z, Böhmer K, Maroz A, Koch ML, Emmrich S, Godinho FJ, Orkin SH, Reinhardt D. miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. Genes & Development. 24: 478-90. PMID 20194440 DOI: 10.1101/Gad.1856210  0.56
2010 Nathan DG, Orkin SH. Musings on genome medicine: Hepatitis C. Genome Medicine. 2: 4. PMID 20193049 DOI: 10.1186/Gm125  1
2010 Alford KA, Slender A, Vanes L, Li Z, Fisher EM, Nizetic D, Orkin SH, Roberts I, Tybulewicz VL. Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome. Blood. 115: 2928-37. PMID 20154221 DOI: 10.1182/Blood-2009-06-227629  0.56
2010 Kim J, Orkin SH. Systematic tracking of cell fate changes. Nature Biotechnology. 28: 146-7. PMID 20139953 DOI: 10.1038/Nbt0210-146  1
2010 Heitmann K, Li Z, Klusmann J, Thakur BK, Schöning J, Bourquin J, Orkin SH, Reinhardt D. Gene Expression-Based Chemical Genomics Identifies Valproic Acid to Revert the Oncogenic Effect of GATA1s In Down Syndrome Megakaryoblastic Leukemia. Blood. 116: 3646-3646. DOI: 10.1182/Blood.V116.21.3646.3646  0.56
2010 Wilson BG, Wang X, Shen X, McKenna ES, Lemieux ME, Cho Y, Koelhoffer EC, Pomeroy SL, Orkin SH, Roberts CWM. Abstract LB-237: Epigenetic antagonism between Polycomb and SWI/SNF complexes duringoncogenic transformation Cancer Research. 71: 4799-4799. DOI: 10.1158/1538-7445.Am2011-Lb-237  0.76
2010 Rao S, Roumiantsev S, McDonald L, Orkin SH. The Role Of Sall4 In Embryonic Stem Cell Pluripotency Biology of Blood and Marrow Transplantation. 16. DOI: 10.1016/J.Bbmt.2009.12.111  0.56
2009 Shen X, Kim W, Fujiwara Y, Simon MD, Liu Y, Mysliwiec MR, Yuan GC, Lee Y, Orkin SH. Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell. 139: 1303-14. PMID 20064376 DOI: 10.1016/J.Cell.2009.12.003  1
2009 Nathan DG, Orkin SH. Musings on genome medicine: enzyme-replacement therapy of the lysosomal storage diseases. Genome Medicine. 1: 114. PMID 20017892 DOI: 10.1186/Gm114  1
2009 Yu M, Riva L, Xie H, Schindler Y, Moran TB, Cheng Y, Yu D, Hardison R, Weiss MJ, Orkin SH, Bernstein BE, Fraenkel E, Cantor AB. Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Molecular Cell. 36: 682-95. PMID 19941827 DOI: 10.1016/J.Molcel.2009.11.002  1
2009 Nathan DG, Orkin SH. Musings on genome medicine: Crohn's disease. Genome Medicine. 1: 103. PMID 19891793 DOI: 10.1186/Gm103  1
2009 Nathan DG, Orkin SH. Musings on genome medicine: the slow but inexorable process of medical care reform in the United States. Genome Medicine. 1: 94. PMID 19822025 DOI: 10.1186/Gm94  1
2009 Trowbridge JJ, Snow JW, Kim J, Orkin SH. DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells. Cell Stem Cell. 5: 442-9. PMID 19796624 DOI: 10.1182/Blood.V114.22.392.392  1
2009 Nathan DG, Orkin SH. Musings on genome medicine: the Obama effect redux. Genome Medicine. 1: 86. PMID 19769781 DOI: 10.1186/Gm86  1
2009 Sankaran VG, Xu J, Ragoczy T, Ippolito GC, Walkley CR, Maika SD, Fujiwara Y, Ito M, Groudine M, Bender MA, Tucker PW, Orkin SH. Developmental and species-divergent globin switching are driven by BCL11A. Nature. 460: 1093-7. PMID 19657335 DOI: 10.1038/Nature08243  1
2009 Snow JW, Orkin SH. Translational isoforms of FOG1 regulate GATA1-interacting complexes. The Journal of Biological Chemistry. 284: 29310-9. PMID 19654328 DOI: 10.1074/Jbc.M109.043497  1
2009 Huang Z, Dore LC, Li Z, Orkin SH, Feng G, Lin S, Crispino JD. GATA-2 reinforces megakaryocyte development in the absence of GATA-1. Molecular and Cellular Biology. 29: 5168-80. PMID 19620289 DOI: 10.1128/Mcb.00482-09  1
2009 Schindler JW, Van Buren D, Foudi A, Krejci O, Qin J, Orkin SH, Hock H. TEL-AML1 corrupts hematopoietic stem cells to persist in the bone marrow and initiate leukemia. Cell Stem Cell. 5: 43-53. PMID 19570513 DOI: 10.1016/J.Stem.2009.04.019  1
2009 Nathan DG, Orkin SH. Musings on genome medicine: cholesterol and coronary artery disease. Genome Medicine. 1: 60. PMID 19519958 DOI: 10.1186/Gm60  1
2009 Nathan DG, Orkin SH. Musings on genome medicine: cancer genetics and the promise of effective treatment. Genome Medicine. 1: 49. PMID 19439059 DOI: 10.1186/Gm49  1
2009 Nathan DG, Orkin SH. Musings on genome medicine: gene therapy. Genome Medicine. 1: 38. PMID 19435468 DOI: 10.1186/Gm38  1
2009 Nathan DG, Orkin SH. Musings on genome medicine: genome wide association studies. Genome Medicine. 1: 3. PMID 19348690 DOI: 10.1186/Gm3  1
2009 Nathan DG, Orkin SH. Musings on genome medicine: the Obama effect. Genome Medicine. 1: 30. PMID 19341501 DOI: 10.1186/Gm30  1
2009 Nathan DG, Orkin SH. Musings on genome medicine: abuse of genetic tests. Genome Medicine. 1: 18. PMID 19341489 DOI: 10.1186/Gm18  1
2009 Hu G, Kim J, Xu Q, Leng Y, Orkin SH, Elledge SJ. A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal Genes and Development. 23: 837-848. PMID 19339689 DOI: 10.1101/Gad.1769609  1
2009 Kim J, Cantor AB, Orkin SH, Wang J. Use of in vivo biotinylation to study protein-protein and protein-DNA interactions in mouse embryonic stem cells. Nature Protocols. 4: 506-17. PMID 19325547 DOI: 10.1038/Nprot.2009.23  1
2009 Wang J, Cantor AB, Orkin SH. Tandem affinity purification of protein complexes in mouse embryonic stem cells using in vivo biotinylation. Current Protocols in Stem Cell Biology. Unit1B.5. PMID 19306258 DOI: 10.1002/9780470151808.Sc01B05S8  1
2009 Gekas C, Rhodes KE, Gereige LM, Helgadottir H, Ferrari R, Kurdistani SK, Montecino-Rodriguez E, Bassel-Duby R, Olson E, Krivtsov AV, Armstrong S, Orkin SH, Pellegrini M, Mikkola HK. Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis. Blood. 113: 3461-71. PMID 19211936 DOI: 10.1182/Blood-2008-07-167577  1
2009 Shen X, Orkin SH. Glimpses of the epigenetic landscape. Cell Stem Cell. 4: 1-2. PMID 19128786 DOI: 10.1016/J.Stem.2008.12.006  1
2009 Klusmann J, Godinho F, Heitmann K, Maroz A, Reinhardt D, Orkin SH, Li Z. Developmental Stage-Specific Interplay Between GATA1 and IGF Signaling in Fetal Hematopoiesis and Leukemogenesis. Blood. 114: 386-386. DOI: 10.1182/Blood.V114.22.386.386  0.56
2009 Pushpanathan T, Klusmann J, Li Z, Böhmer K, Godinho F, Koch M, Orkin S, Reinhardt D. Oncogenic Potential of miR-125b-2 and its Target Genes in Normal and Malignant Hematopoesis Klinische Padiatrie. 221. DOI: 10.1055/S-0029-1222671  0.56
2009 Klusmann J, Godinho F, Heitmann K, Pushpanathan T, Reinhardt D, Orkin S, Li Z. Developmental stage-specific interplay between GATA1 and IGF signaling during fetal hematopoiesis and leukemogenesis Klinische Padiatrie. 221. DOI: 10.1055/S-0029-1222650  0.56
2009 Heitmann K, Thakur B, Li Z, Schöning J, Bourquin J, Reinhardt D, Orkin S, Klusmann J. Gene expression-based chemical genomics identifies VPA to revert the oncogenic effect of GATA1s in Down syndrome leukemia Klinische Padiatrie. 221. DOI: 10.1055/S-0029-1222645  0.56
2009 Fujiwara Y, Orkin SH. Molecular regulation of the state of embryonic stem cells Stem Cells and Cancer. 33-60. DOI: 10.1007/978-0-387-89611-3_2  1
2008 Wang J, Trowbridge JJ, Rao S, Orkin SH. Proteomic studies of stem cells Stembook. PMID 20614589 DOI: 10.3824/Stembook.1.4.1  1
2008 Orkin SH, Wang J, Kim J, Chu J, Rao S, Theunissen TW, Shen X, Levasseur DN. The transcriptional network controlling pluripotency in ES cells Cold Spring Harbor Symposia On Quantitative Biology. 73: 195-202. PMID 19478325 DOI: 10.1101/Sqb.2008.72.001  1
2008 Sankaran VG, Menne TF, Xu J, Akie TE, Lettre G, Van Handel B, Mikkola HK, Hirschhorn JN, Cantor AB, Orkin SH. Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science (New York, N.Y.). 322: 1839-42. PMID 19056937 DOI: 10.1126/science.1165409  1
2008 Shen X, Liu Y, Hsu YJ, Fujiwara Y, Kim J, Mao X, Yuan GC, Orkin SH. EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Molecular Cell. 32: 491-502. PMID 19026780 DOI: 10.1016/J.Molcel.2008.10.016  1
2008 Walkley CR, Sankaran VG, Orkin SH. Rb and hematopoiesis: stem cells to anemia. Cell Division. 3: 13. PMID 18775080 DOI: 10.1186/1747-1028-3-13  1
2008 Beuling E, Bosse T, aan de Kerk DJ, Piaseckyj CM, Fujiwara Y, Katz SG, Orkin SH, Grand RJ, Krasinski SD. GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors. Developmental Biology. 322: 179-89. PMID 18692040 DOI: 10.1016/J.Ydbio.2008.07.022  1
2008 Lettre G, Sankaran VG, Bezerra MA, Araújo AS, Uda M, Sanna S, Cao A, Schlessinger D, Costa FF, Hirschhorn JN, Orkin SH. DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Proceedings of the National Academy of Sciences of the United States of America. 105: 11869-74. PMID 18667698 DOI: 10.1073/Pnas.0804799105  1
2008 Walkley CR, Qudsi R, Sankaran VG, Perry JA, Gostissa M, Roth SI, Rodda SJ, Snay E, Dunning P, Fahey FH, Alt FW, McMahon AP, Orkin SH. Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes & Development. 22: 1662-76. PMID 18559481 DOI: 10.1101/Gad.1656808  1
2008 Wang J, Levasseur DN, Orkin SH. Requirement of Nanog dimerization for stem cell self-renewal and pluripotency. Proceedings of the National Academy of Sciences of the United States of America. 105: 6326-31. PMID 18436640 DOI: 10.1073/Pnas.0802288105  1
2008 Sue N, Jack BH, Eaton SA, Pearson RC, Funnell AP, Turner J, Czolij R, Denyer G, Bao S, Molero-Navajas JC, Perkins A, Fujiwara Y, Orkin SH, Bell-Anderson K, Crossley M. Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis. Molecular and Cellular Biology. 28: 3967-78. PMID 18391014 DOI: 10.1128/Mcb.01942-07  1
2008 Rhodes KE, Gekas C, Wang Y, Lux CT, Francis CS, Chan DN, Conway S, Orkin SH, Yoder MC, Mikkola HK. The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation. Cell Stem Cell. 2: 252-63. PMID 18371450 DOI: 10.1016/J.Stem.2008.01.001  1
2008 Kim J, Chu J, Shen X, Wang J, Orkin SH. An extended transcriptional network for pluripotency of embryonic stem cells. Cell. 132: 1049-61. PMID 18358816 DOI: 10.1016/J.Cell.2008.02.039  1
2008 Puschendorf M, Terranova R, Boutsma E, Mao X, Isono K, Brykczynska U, Kolb C, Otte AP, Koseki H, Orkin SH, Lohuizen Mv, Peters AHFM. PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos Nature Genetics. 40: 411-420. PMID 18311137 DOI: 10.1038/Ng.99  0.64
2008 Cantor AB, Iwasaki H, Arinobu Y, Moran TB, Shigematsu H, Sullivan MR, Akashi K, Orkin SH. Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage. The Journal of Experimental Medicine. 205: 611-24. PMID 18299398 DOI: 10.1084/Jem.20070544  1
2008 Orkin SH, Zon LI. SnapShot: Hematopoiesis Cell. 132. PMID 18295585 DOI: 10.1016/j.cell.2008.02.013  1
2008 Orkin SH, Zon LI. Hematopoiesis: An Evolving Paradigm for Stem Cell Biology Cell. 132: 631-644. PMID 18295580 DOI: 10.1016/J.Cell.2008.01.025  1
2008 Levasseur DN, Wang J, Dorschner MO, Stamatoyannopoulos JA, Orkin SH. Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells. Genes & Development. 22: 575-80. PMID 18283123 DOI: 10.1101/Gad.1606308  1
2008 Sankaran VG, Orkin SH, Walkley CR. Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis. Genes & Development. 22: 463-75. PMID 18258751 DOI: 10.1182/Blood.V110.11.638.638  1
2008 Uda M, Galanello R, Sanna S, Lettre G, Sankaran VG, Chen W, Usala G, Busonero F, Maschio A, Albai G, Piras MG, Sestu N, Lai S, Dei M, Mulas A, ... ... Orkin SH, et al. Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. Proceedings of the National Academy of Sciences of the United States of America. 105: 1620-5. PMID 18245381 DOI: 10.1073/Pnas.0711566105  1
2008 Wang J, Orkin SH. A protein roadmap to pluripotency and faithful reprogramming Cells Tissues Organs. 188: 23-30. PMID 18196921 DOI: 10.1159/000113532  1
2008 Klusmann J, Godinho F, Pushpanathan T, Reinhardt D, Orkin SH, Li Z. GATA1s Mutant Protein Contributes to “Down” Syndrome Megakaryoblastic Leukemia by Derepression of E2F Targets. Blood. 112: 2248-2248. DOI: 10.1182/Blood.V112.11.2248.2248  0.56
2008 Wang J, Levasseur DN, Orkin SH. Requirement of Nanog dimerization for stem cell self-renewal and pluripotency (Proceedings of the National Academy of Sciences of the United States of America (2008) 105:17 (6326-6331) DOI: 10.1073/pnas.0802288105) Proceedings of the National Academy of Sciences of the United States of America. 105: 8801-8802. DOI: 10.1073/pnas.0804442105  1
2008 Kim J, Chu J, Shen X, Wang J, Orkin SH. An Extended Transcriptional Network for Pluripotency of Embryonic Stem Cells (DOI:10.1016/j.cell.2008.02.039) Cell. 133. DOI: 10.1016/J.Cell.2008.06.004  1
2007 Orkin SH, Pera M. Stem cells down under-ISSCR 2007 Cell Stem Cell. 1: 271-276. PMID 18399027 DOI: 10.1016/J.Stem.2007.08.007  1
2007 Wang J, Theunissen TW, Orkin SH. Site-directed, virus-free, and inducible RNAi in embryonic stem cells Proceedings of the National Academy of Sciences of the United States of America. 104: 20850-20855. PMID 18093939 DOI: 10.1073/Pnas.0710565105  1
2007 Li Z, Tognon CE, Godinho FJ, Yasaitis L, Hock H, Herschkowitz JI, Lannon CL, Cho E, Kim SJ, Bronson RT, Perou CM, Sorensen PH, Orkin SH. ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex. Cancer Cell. 12: 542-58. PMID 18068631 DOI: 10.1016/J.Ccr.2007.11.012  1
2007 Xie H, Orkin SH. Immunology: Changed destiny Nature. 449: 410-411. PMID 17898754 DOI: 10.1038/449410A  1
2007 Saleque S, Kim J, Rooke HM, Orkin SH. Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Molecular Cell. 27: 562-72. PMID 17707228 DOI: 10.1016/J.Molcel.2007.06.039  1
2007 North TE, Goessling W, Walkley CR, Lengerke C, Kopani KR, Lord AM, Weber GJ, Bowman TV, Jang IH, Grosser T, Fitzgerald GA, Daley GQ, Orkin SH, Zon LI. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 447: 1007-11. PMID 17581586 DOI: 10.1038/Nature05883  1
2007 Walkley CR, Shea JM, Sims NA, Purton LE, Orkin SH. Rb Regulates Interactions between Hematopoietic Stem Cells and Their Bone Marrow Microenvironment Cell. 129: 1081-1095. PMID 17574022 DOI: 10.1016/J.Cell.2007.03.055  0.44
2007 Ackerman KG, Wang J, Luo L, Fujiwara Y, Orkin SH, Beier DR. Gata4 is necessary for normal pulmonary lobar development. American Journal of Respiratory Cell and Molecular Biology. 36: 391-7. PMID 17142311 DOI: 10.1165/Rcmb.2006-0211Rc  1
2007 Klusmann J, Janikova K, Li Z, Orkin SH, Reinhardt D. Chromosome 21-Encoded miR-125b and Its Role in the Development of Myeloid Leukemia in Children with Down’s Syndrome. Blood. 110: 716-716. DOI: 10.1182/Blood.V110.11.716.716  0.56
2006 Wu SM, Fujiwara Y, Cibulsky SM, Clapham DE, Lien CL, Schultheiss TM, Orkin SH. Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell. 127: 1137-50. PMID 17123591 DOI: 10.1016/J.Cell.2006.10.028  1
2006 Wang J, Rao S, Chu J, Shen X, Levasseur DN, Theunissen TW, Orkin SH. A protein interaction network for pluripotency of embryonic stem cells. Nature. 444: 364-8. PMID 17093407 DOI: 10.1038/Nature05284  1
2006 Mikkola HK, Orkin SH. The journey of developing hematopoietic stem cells. Development (Cambridge, England). 133: 3733-44. PMID 16968814 DOI: 10.1242/Dev.02568  1
2006 Rao S, Orkin SH. Unraveling the transcriptional network controlling ES cell pluripotency Genome Biology. 7. PMID 16942632 DOI: 10.1186/Gb-2006-7-8-230  1
2006 Walkley CR, Orkin SH. Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cells Proceedings of the National Academy of Sciences of the United States of America. 103: 9057-9062. PMID 16754850 DOI: 10.1073/Pnas.0603389103  1
2006 Pooter RFd, Schmitt TM, Pompa JLdl, Fujiwara Y, Orkin SH, Zúñiga-Pflücker JC. Notch Signaling Requires GATA-2 to Inhibit Myelopoiesis from Embryonic Stem Cells and Primary Hemopoietic Progenitors Journal of Immunology. 176: 5267-5275. PMID 16621992 DOI: 10.4049/Jimmunol.176.9.5267  1
2006 Guyot B, Murai K, Fujiwara Y, Valverde-Garduno V, Hammett M, Wells S, Dear N, Orkin SH, Porcher C, Vyas P. Characterization of a megakaryocyte-specific enhancer of the key hemopoietic transcription factor GATA1. Journal of Biological Chemistry. 281: 13733-13742. PMID 16551635 DOI: 10.1074/Jbc.M602052200  1
2006 Bourquin JP, Subramanian A, Langebrake C, Reinhardt D, Bernard O, Ballerini P, Baruchel A, Cavé H, Dastugue N, Hasle H, Kaspers GL, Lessard M, Michaux L, Vyas P, van Wering E, ... ... Orkin SH, et al. Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling. Proceedings of the National Academy of Sciences of the United States of America. 103: 3339-44. PMID 16492768 DOI: 10.1073/Pnas.0511150103  1
2006 Orkin SH. Reactions to the Hwang scandal [2] Science. 311: 606-607. PMID 16459362  1
2006 Rooke HM, Orkin SH. Phosphorylation of Gata1 at serine residues 72, 142, and 310 is not essential for hematopoiesis in vivo Blood. 107: 3527-3530. PMID 16391009 DOI: 10.1182/Blood-2005-10-4309  1
2006 Hock H, Orkin SH. Zinc-finger transcription factor Gfi-1: versatile regulator of lymphocytes, neutrophils and hematopoietic stem cells. Current Opinion in Hematology. 13: 1-6. PMID 16319680 DOI: 10.1097/01.Moh.0000190111.85284.8F  1
2005 Muroyama Y, Fujiwara Y, Orkin SH, Rowitch DH. Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube Nature. 438: 360-363. PMID 16292311 DOI: 10.1038/Nature04139  1
2005 Orkin SH. Chipping away at the embryonic stem cell network Cell. 122: 828-830. PMID 16179251 DOI: 10.1016/J.Cell.2005.09.002  1
2005 Mikkola HK, Gekas C, Orkin SH, Dieterlen-Lievre F. Placenta as a site for hematopoietic stem cell development. Experimental Hematology. 33: 1048-54. PMID 16140153 DOI: 10.1016/J.Exphem.2005.06.011  1
2005 Kadri Z, Maouche-Chretien L, Rooke HM, Orkin SH, Romeo PH, Mayeux P, Leboulch P, Chretien S. Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation Molecular and Cellular Biology. 25: 7412-7422. PMID 16107690 DOI: 10.1128/Mcb.25.17.7412-7422.2005  1
2005 Tsai J, Tong Q, Tan G, Chang AN, Orkin SH, Hotamisligil GS. The transcription factor GATA2 regulates differentiation of brown adipocytes. Embo Reports. 6: 879-84. PMID 16082385 DOI: 10.1038/Sj.Embor.7400490  1
2005 Hock H, Orkin SH. Stem cells: the road not taken. Nature. 435: 573-5. PMID 15931202 DOI: 10.1038/435573A  1
2005 Li Z, Godinho FJ, Klusmann JH, Garriga-Canut M, Yu C, Orkin SH. Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nature Genetics. 37: 613-9. PMID 15895080 DOI: 10.1038/Ng1566  0.56
2005 Sun T, Patoine C, Abu-Khalil A, Visvader J, Sum E, Cherry TJ, Orkin SH, Geschwind DH, Walsh CA. Early asymmetry of gene transcription in embryonic human left and right cerebral cortex. Science (New York, N.Y.). 308: 1794-8. PMID 15894532 DOI: 10.1126/Science.1110324  1
2005 Rodrigues NP, Janzen V, Forkert R, Dombkowski DM, Boyd AS, Orkin SH, Enver T, Vyas P, Scadden DT. Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis Blood. 106: 477-484. PMID 15811962 DOI: 10.1182/Blood-2004-08-2989  1
2005 Gekas C, Dieterlen-Lièvre F, Orkin SH, Mikkola HK. The placenta is a niche for hematopoietic stem cells. Developmental Cell. 8: 365-75. PMID 15737932 DOI: 10.1016/J.Devcel.2004.12.016  1
2005 Schlaeger TM, Mikkola HK, Gekas C, Helgadottir HB, Orkin SH. Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development. Blood. 105: 3871-4. PMID 15677556 DOI: 10.1182/Blood-2004-11-4467  1
2005 Cantor AB, Orkin SH. Coregulation of GATA factors by the Friend of GATA (FOG) family of multitype zinc finger proteins. Seminars in Cell & Developmental Biology. 16: 117-28. PMID 15659346 DOI: 10.1016/J.Semcdb.2004.10.006  1
2005 Mikkola HK, Orkin SH. Gene targeting and transgenic strategies for the analysis of hematopoietic development in the mouse. Methods in Molecular Medicine. 105: 3-22. PMID 15492385 DOI: 10.1385/1-59259-826-9:003  1
2005 Guyot B, Murai K, Fujiwara Y, Valverde-Garduno V, Hammett M, Wells S, Dear N, Orkin SH, Porcher C, Vyas P. Characterization of a Megakaryocyte-Specific Enhancer of the Key Hemopoietic Transcription Factor GATA1. Blood. 106: 834-834. DOI: 10.1182/Blood.V106.11.834.834  1
2005 Li Z, Klusmann J, Godinho FJ, Lee H, Reinhardt D, Orkin SH. A Genome-Wide Retroviral Insertional Mutagenesis Screen for Genes Cooperating with Truncated, Oncogenic GATA1s. Blood. 106: 2990-2990. DOI: 10.1182/Blood.V106.11.2990.2990  0.56
2004 Ling KW, Ottersbach K, van Hamburg JP, Oziemlak A, Tsai FY, Orkin SH, Ploemacher R, Hendriks RW, Dzierzak E. GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells. The Journal of Experimental Medicine. 200: 871-82. PMID 15466621 DOI: 10.1084/Jem.20031556  0.48
2004 Hock H, Hamblen MJ, Rooke HM, Schindler JW, Saleque S, Fujiwara Y, Orkin SH. Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature. 431: 1002-7. PMID 15457180 DOI: 10.1038/Nature02994  1
2004 Humbles AA, Lloyd CM, McMillan SJ, Friend DS, Xanthou G, McKenna EE, Ghiran S, Gerard NP, Yu C, Orkin SH, Gerard C. A critical role for eosinophils in allergic airways remodeling. Science (New York, N.Y.). 305: 1776-9. PMID 15375268 DOI: 10.1126/Science.1100283  1
2004 Hock H, Meade E, Medeiros S, Schindler JW, Valk PJ, Fujiwara Y, Orkin SH. Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Genes & Development. 18: 2336-41. PMID 15371326 DOI: 10.1101/Gad.1239604  1
2004 Ransom DG, Bahary N, Niss K, Traver D, Burns C, Trede NS, Paffett-Lugassy N, Saganic WJ, Lim CA, Hersey C, Zhou Y, Barut BA, Lin S, Kingsley PD, Palis J, ... Orkin SH, et al. The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis. Plos Biology. 2: E237. PMID 15314655 DOI: 10.1371/Journal.Pbio.0020237  1
2004 Schlaeger TM, Schuh A, Flitter S, Fisher A, Mikkola H, Orkin SH, Vyas P, Porcher C. Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1. Molecular and Cellular Biology. 24: 7491-502. PMID 15314159 DOI: 10.1128/Mcb.24.17.7491-7502.2004  1
2004 Tuveson DA, Shaw AT, Willis NA, Silver DP, Jackson EL, Chang S, Mercer KL, Grochow R, Hock H, Crowley D, Hingorani SR, Zaks T, King C, Jacobetz MA, Wang L, ... ... Orkin SH, et al. Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell. 5: 375-87. PMID 15093544 DOI: 10.1016/S1535-6108(04)00085-6  1
2004 Garriga-Canut M, Orkin SH. Transforming acidic coiled-coil protein 3 (TACC3) controls friend of GATA-1 (FOG-1) subcellular localization and regulates the association between GATA-1 and FOG-1 during hematopoiesis Journal of Biological Chemistry. 279: 23597-23605. PMID 15037632 DOI: 10.1074/Jbc.M313987200  1
2004 Hahm K, Sum EY, Fujiwara Y, Lindeman GJ, Visvader JE, Orkin SH. Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1. Molecular and Cellular Biology. 24: 2074-82. PMID 14966286 DOI: 10.1128/Mcb.24.5.2074-2082.2004  1
2004 Roberts CW, Orkin SH. The SWI/SNF complex--chromatin and cancer. Nature Reviews. Cancer. 4: 133-42. PMID 14964309 DOI: 10.1038/Nrc1273  1
2004 Smith ED, Xu Y, Tomson BN, Leung CG, Fujiwara Y, Orkin SH, Crispino JD. More than blood, a novel gene required for mammalian postimplantation development. Molecular and Cellular Biology. 24: 1168-73. PMID 14729962 DOI: 10.1128/Mcb.24.3.1168-1173.2004  1
2004 Pal S, Cantor AB, Johnson KD, Moran TB, Boyer ME, Orkin SH, Bresnick EH. Coregulator-dependent facilitation of chromatin occupancy by GATA-1. Proceedings of the National Academy of Sciences of the United States of America. 101: 980-5. PMID 14715908 DOI: 10.1073/Pnas.0307612100  1
2004 Fujiwara Y, Chang AN, Williams AM, Orkin SH. Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development. Blood. 103: 583-5. PMID 14504093 DOI: 10.1182/Blood-2003-08-2870  1
2003 Orkin SH. Priming the hematopoietic pump Immunity. 19: 633-634. PMID 14614848 DOI: 10.1016/S1074-7613(03)00302-9  1
2003 Katz SG, Williams A, Yang J, Fujiwara Y, Tsang AP, Epstein JA, Orkin SH. Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development. Proceedings of the National Academy of Sciences of the United States of America. 100: 14030-5. PMID 14614148 DOI: 10.1073/Pnas.1936250100  1
2003 Fossett N, Hyman K, Gajewski K, Orkin SH, Schulz RA. Combinatorial interactions of serpent, lozenge, and U-shaped regulate crystal cell lineage commitment during Drosophila hematopoiesis. Proceedings of the National Academy of Sciences of the United States of America. 100: 11451-6. PMID 14504400 DOI: 10.1073/Pnas.1635050100  1
2003 Neumann CA, Krause DS, Carman CV, Das S, Dubey DP, Abraham JL, Bronson RT, Fujiwara Y, Orkin SH, Van Etten RA. Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature. 424: 561-5. PMID 12891360 DOI: 10.1038/Nature01819  1
2003 Ema M, Faloon P, Zhang WJ, Hirashima M, Reid T, Stanford WL, Orkin S, Choi K, Rossant J. Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse Genes and Development. 17: 380-393. PMID 12569129 DOI: 10.1101/Gad.1049803  1
2003 Mikkola HK, Klintman J, Yang H, Hock H, Schlaeger TM, Fujiwara Y, Orkin SH. Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature. 421: 547-51. PMID 12540851 DOI: 10.1038/Nature01345  1
2003 Hock H, Hamblen MJ, Rooke HM, Traver D, Bronson RT, Cameron S, Orkin SH. Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. Immunity. 18: 109-20. PMID 12530980 DOI: 10.1016/S1074-7613(02)00501-0  1
2003 Wallis D, Hamblen M, Zhou Y, Venken KJ, Schumacher A, Grimes HL, Zoghbi HY, Orkin SH, Bellen HJ. The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival. Development (Cambridge, England). 130: 221-32. PMID 12441305 DOI: 10.1242/Dev.00190  1
2003 Mikkola HK, Fujiwara Y, Schlaeger TM, Traver D, Orkin SH. Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood. 101: 508-16. PMID 12393529 DOI: 10.1182/Blood-2002-06-1699  1
2003 Turner J, Holmes M, Czoli R, Gaensler K, Yang H, Fujiwara Y, Chong B, Koh P, Perkins A, Orkin S, Crossley M. Basic Kruppel-like factor recruits multiple co-repressors to silence gene expression Blood Cells Molecules and Diseases. 31: 135-136. DOI: 10.1016/S1079-9796(03)00043-3  1
2002 Lécuyer E, Herblot S, Saint-Denis M, Martin R, Begley CG, Porcher C, Orkin SH, Hoang T. The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1. Blood. 100: 2430-40. PMID 12239153 DOI: 10.1182/Blood-2002-02-0568  1
2002 Ritchie KJ, Malakhov MP, Hetherington CJ, Zhou L, Little MT, Malakhova OA, Sipe JC, Orkin SH, Zhang DE. Dysregulation of protein modification by ISG15 results in brain cell injury. Genes & Development. 16: 2207-12. PMID 12208842 DOI: 10.1101/Gad.1010202  0.32
2002 Yu C, Niakan KK, Matsushita M, Stamatoyannopoulos G, Orkin SH, Raskind WH. X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction. Blood. 100: 2040-5. PMID 12200364 DOI: 10.1182/Blood-2002-02-0387  1
2002 Orkin SH, Morrison SJ. Stem-cell competition. Nature. 418: 25-7. PMID 12097889 DOI: 10.1038/418025A  1
2002 Chang AN, Cantor AB, Fujiwara Y, Lodish MB, Droho S, Crispino JD, Orkin SH. GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis. Proceedings of the National Academy of Sciences of the United States of America. 99: 9237-42. PMID 12077323 DOI: 10.1073/Pnas.142302099  1
2002 Crispino JD, Orkin SH. The use of altered specificity mutants to probe specific protein-protein interactions involved in the activation of GATA-1 target genes. Methods (San Diego, Calif.). 26: 84-92. PMID 12054907 DOI: 10.1016/S1046-2023(02)00010-5  1
2002 Yu C, Cantor AB, Yang H, Browne C, Wells RA, Fujiwara Y, Orkin SH. Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. The Journal of Experimental Medicine. 195: 1387-95. PMID 12045237 DOI: 10.1084/Jem.20020656  1
2002 Cantor AB, Orkin SH. Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene. 21: 3368-76. PMID 12032775 DOI: 10.1038/Sj.Onc.1205326  1
2002 Cantor AB, Katz SG, Orkin SH. Distinct domains of the GATA-1 cofactor FOG-1 differentially influence erythroid versus megakaryocytic maturation. Molecular and Cellular Biology. 22: 4268-79. PMID 12024038 DOI: 10.1128/Mcb.22.12.4268-4279.2002  1
2002 Katz SG, Cantor AB, Orkin SH. Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo. Molecular and Cellular Biology. 22: 3121-8. PMID 11940669 DOI: 10.1128/Mcb.22.9.3121-3128.2002  1
2002 Orkin SH, Zon LI. Hematopoiesis and stem cells: Plasticity versus development heterogeneity Nature Immunology. 3: 323-328. PMID 11919568 DOI: 10.1038/Ni0402-323  1
2002 Mikkola HK, Orkin SH. The search for the hemangioblast. Journal of Hematotherapy & Stem Cell Research. 11: 9-17. PMID 11847000 DOI: 10.1089/152581602753448504  1
2002 Saleque S, Cameron S, Orkin SH. The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages Genes and Development. 16: 301-306. PMID 11825872 DOI: 10.1101/Gad.959102  1
2001 Murga M, Fernández-Capetillo O, Field SJ, Moreno B, Borlado LR, Fujiwara Y, Balomenos D, Vicario A, Carrera AC, Orkin SH, Greenberg ME, Zubiaga AM. Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity. Immunity. 15: 959-70. PMID 11754817 DOI: 10.1016/S1074-7613(01)00254-0  1
2001 Han AP, Yu C, Lu L, Fujiwara Y, Browne C, Chin G, Fleming M, Leboulch P, Orkin SH, Chen JJ. Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency. The Embo Journal. 20: 6909-18. PMID 11726526 DOI: 10.1093/Emboj/20.23.6909  1
2001 Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, Nuckolls F, Giangrande P, Wright FA, Field SJ, Greenberg ME, Orkin S, Nevins JR, Robinson ML, Leone G. The E2F1-3 transcription factors are essential for cellular proliferation. Nature. 414: 457-62. PMID 11719808 DOI: 10.1038/35106593  1
2001 Zhou M, Ouyang W, Gong Q, Katz SG, White JM, Orkin SH, Murphy KM. Friend of GATA-1 represses GATA-3-dependent activity in CD4+ T cells. The Journal of Experimental Medicine. 194: 1461-71. PMID 11714753 DOI: 10.1084/Jem.194.10.1461  1
2001 Zhu JW, Field SJ, Gore L, Thompson M, Yang H, Fujiwara Y, Cardiff RD, Greenberg M, Orkin SH, DeGregori J. E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis Molecular and Cellular Biology. 21: 8547-8564. PMID 11713289 DOI: 10.1128/Mcb.21.24.8547-8564.2001  1
2001 Jasinski M, Keller P, Fujiwara Y, Orkin SH, Bessler M. GATA1-Cre mediates Piga gene inactivation in the erythroid/megakaryocytic lineage and leads to circulating red cells with a partial deficiency in glycosyl phosphatidylinositol-linked proteins (paroxysmal nocturnal hemoglobinuria type II cells). Blood. 98: 2248-2255. PMID 11568013 DOI: 10.1182/Blood.V98.7.2248  1
2001 Cantor AB, Orkin SH. Hematopoietic development: a balancing act. Current Opinion in Genetics & Development. 11: 513-9. PMID 11532392 DOI: 10.1016/S0959-437X(00)00226-4  1
2001 Leone G, Sears R, Huang E, Rempel R, Nuckolls F, Park CH, Giangrande P, Wu L, Saavedra HI, Field SJ, Thompson MA, Yang H, Fujiwara Y, Greenberg ME, Orkin S, et al. Myc requires distinct E2F activities to induce S phase and apoptosis. Molecular Cell. 8: 105-13. PMID 11511364 DOI: 10.1016/S1097-2765(01)00275-1  1
2001 Mead PE, Deconinck AE, Huber TL, Orkin SH, Zon LI. Primitive erythropoiesis in the Xenopus embryo: the synergistic role of LMO-2, SCL and GATA-binding proteins. Development (Cambridge, England). 128: 2301-8. PMID 11493549  1
2001 Fossett N, Tevosian SG, Gajewski K, Zhang Q, Orkin SH, Schulz RA. The Friend of GATA proteins U-shaped, FOG-1, and FOG-2 function as negative regulators of blood, heart, and eye development in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 98: 7342-7. PMID 11404479 DOI: 10.1073/Pnas.131215798  1
2001 Crispino JD, Lodish MB, Thurberg BL, Litovsky SH, Collins T, Molkentin JD, Orkin SH. Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors Genes and Development. 15: 839-844. PMID 11297508 DOI: 10.1101/Gad.875201  1
2001 Mao X, Fujiwara Y, Chapdelaine A, Yang H, Orkin SH. Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain. Blood. 97: 324-6. PMID 11133778 DOI: 10.1182/Blood.V97.1.324  1
2001 Lassar AB, Orkin S. Cell differentiation: Plasticity and commitment - Developmental decisions in the life of a cell Current Opinion in Cell Biology. 13: 659-661. DOI: 10.1016/S0955-0674(00)00267-2  1
2000 Orkin SH. Diversification of haematopoietic stem cells to specific lineages Nature Reviews Genetics. 1: 57-64. PMID 11262875 DOI: 10.1038/35049577  1
2000 Roberts CWM, Galusha SA, McMenamin ME, Fletcher CDM, Orkin SH. Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice Proceedings of the National Academy of Sciences of the United States of America. 97: 13796-13800. PMID 11095756 DOI: 10.1073/Pnas.250492697  0.44
2000 Orkin SH. Stem cell alchemy Nature Medicine. 6: 1212-1213. PMID 11062526 DOI: 10.1038/81303  1
2000 Zhang P, Zhang X, Iwama A, Yu C, Smith KA, Mueller BU, Narravula S, Torbett BE, Orkin SH, Tenen DG. PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding. Blood. 96: 2641-8. PMID 11023493 DOI: 10.1182/Blood.V96.8.2641  0.56
2000 Querfurth E, Schuster M, Kulessa H, Crispino JD, Döderlein G, Orkin SH, Graf T, Nerlov C. Antagonism between C/EBPβ and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors Genes and Development. 14: 2515-2525. PMID 11018018 DOI: 10.1101/Gad.177200  1
2000 Chen F, Ma L, Parrini MC, Mao X, Lopez M, Wu C, Marks PW, Davidson L, Kwiatkowski DJ, Kirchhausen T, Orkin SH, Rosen FS, Mayer BJ, Kirschner MW, Alt FW. Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability. Current Biology : Cb. 10: 758-65. PMID 10898977 DOI: 10.1016/S0960-9822(00)00571-6  1
2000 Tevosian SG, Deconinck AE, Tanaka M, Schinke M, Litovsky SH, Izumo S, Fujiwara Y, Orkin SH. FOG-2, a Cofactor for GATA Transcription Factors, Is Essential for Heart Morphogenesis and Development of Coronary Vessels from Epicardium Cell. 101: 729-739. PMID 10892744 DOI: 10.1016/S0092-8674(00)80885-5  1
2000 Lewis BA, Kim TK, Orkin SH. A downstream element in the human β-globin promoter: Evidence of extended sequence-specific transcription factor IID contacts Proceedings of the National Academy of Sciences of the United States of America. 97: 7172-7177. PMID 10840054 DOI: 10.1073/Pnas.120181197  1
2000 Shirihai OS, Gregory T, Yu C, Orkin SH, Weiss MJ. ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation. The Embo Journal. 19: 2492-502. PMID 10835348 DOI: 10.1093/Emboj/19.11.2492  0.56
2000 Deconinck AE, Mead PE, Tevosian SG, Crispino JD, Katz SG, Zon LI, Orkin SH. FOG acts as a repressor of red blood cell development in Xenopus Development. 127: 2031-2040. PMID 10769228  1
2000 Nichols KE, Crispino JD, Poncz M, White JG, Orkin SH, Maris JM, Weiss MJ. Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA 1 Nature Genetics. 24: 266-270. PMID 10700180 DOI: 10.1038/73480  1
2000 Reimold AM, Etkin A, Clauss I, Perkins A, Friend DS, Zhang J, Horton HF, Scott A, Orkin SH, Byrne MC, Grusby MJ, Glimcher LH. An essential role in liver development for transcription factor XBP-1. Genes & Development. 14: 152-7. PMID 10652269 DOI: 10.1101/Gad.14.2.152  1
2000 Perkins AC, Peterson KR, Stamatoyannopoulos G, Witkowska HE, Orkin SH. Fetal expression of a human Aγ globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos Blood. 95: 1827-1833. DOI: 10.1182/Blood.V95.5.1827.004K10_1827_1833  1
1999 Orkin SH, Weiss MJ. Cutting red-cell production Nature. 401: 433-436. PMID 10519540 DOI: 10.1038/46699  1
1999 Porcher C, Liao EC, Fujiwara Y, Zon LI, Orkin SH. Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding. Development (Cambridge, England). 126: 4603-15. PMID 10498694  1
1999 Gregory T, Yu C, Ma A, Orkin SH, Blobel GA, Weiss MJ. GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-x(L) expression Blood. 94: 87-96. PMID 10381501  1
1999 Strauss EC, Orkin SH. Guanine-adenine ligation-mediated polymerase chain reaction in vivo footprinting Methods in Enzymology. 304: 572-584. PMID 10372382 DOI: 10.1016/S0076-6879(99)04033-1  1
1999 Nardelli J, Thiesson D, Fujiwara Y, Tsai F, Orkin SH. Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system. Developmental Biology. 210: 305-321. PMID 10357893 DOI: 10.1006/Dbio.1999.9278  1
1999 Mao X, Fujiwara Y, Orkin SH. Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice Proceedings of the National Academy of Sciences of the United States of America. 96: 5037-5042. PMID 10220414 DOI: 10.1073/Pnas.96.9.5037  1
1999 Crispino JD, Lodish MB, MacKay JP, Orkin SH. Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: The GATA-1:FOG complex Molecular Cell. 3: 219-228. PMID 10078204 DOI: 10.1016/S1097-2765(00)80312-3  1
1999 Tevosian SG, Deconinck AE, Cantor AB, Rieff HI, Fujiwara Y, Corfas G, Orkin SH. FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped. Proceedings of the National Academy of Sciences of the United States of America. 96: 950-5. PMID 9927674 DOI: 10.1073/Pnas.96.3.950  1
1998 Orkin SH, Shivdasani RA, Fujiwara Y, McDevitt MA. Transcription factor GATA-1 in megakaryocyte development Stem Cells (Dayton, Ohio). 16: 79-83. PMID 11012179 DOI: 10.1002/Stem.5530160710  1
1998 Gao Y, Sun Y, Frank KM, Dikkes P, Fujiwara Y, Seidl KJ, Sekiguchi JM, Rathbun GA, Swat W, Wang J, Bronson RT, Malynn BA, Bryans M, Zhu C, Chaudhuri J, ... ... Orkin SH, et al. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell. 95: 891-902. PMID 9875844 DOI: 10.1016/S0092-8674(00)81714-6  1
1998 Orkin SH. Embryonic stem cells and transgenic mice in the study of hematopoiesis International Journal of Developmental Biology. 42: 927-934. PMID 9853823 DOI: 10.1387/Ijdb.9853823  1
1998 Zhou Y, Lim KC, Onodera K, Takahashi S, Ohta J, Minegishi N, Tsai FY, Orkin SH, Yamamoto M, Engel JD. Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA-2 in urogenital development Embo Journal. 17: 6689-6700. PMID 9822612 DOI: 10.1093/Emboj/17.22.6689  1
1998 Wang LC, Swat W, Fujiwara Y, Davidson L, Visvader J, Kuo F, Alt FW, Gilliland DG, Golub TR, Orkin SH. The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow. Genes & Development. 12: 2392-402. PMID 9694803 DOI: 10.1101/Gad.12.15.2392  1
1998 Tsai FY, Browne CP, Orkin SH. Knock-in mutation of transcription factor GATA-3 into the GATA-1 locus: partial rescue of GATA-1 loss of function in erythroid cells. Developmental Biology. 196: 218-27. PMID 9576834 DOI: 10.1006/Dbio.1997.8842  1
1998 Tsang AP, Fujiwara Y, Horn DB, Orkin SH. Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG Genes and Development. 12: 1176-1188. PMID 9553047 DOI: 10.1101/Gad.12.8.1176  1
1998 Blobel GA, Nakajima T, Eckner R, Montminy M, Orkin SH. CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation Proceedings of the National Academy of Sciences of the United States of America. 95: 2061-2066. PMID 9482838 DOI: 10.1073/Pnas.95.5.2061  1
1998 Visvader JE, Fujiwara Y, Orkin SH. Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development. Genes & Development. 12: 473-9. PMID 9472016 DOI: 10.1101/Gad.12.4.473  1
1998 Guy LG, Mei Q, Perkins AC, Orkin SH, Wall L. Erythroid Krüppel-Like Factor Is Essential for β-Globin Gene Expression Even in Absence of Gene Competition, But Is Not Sufficient to Induce the Switch From γ-Globin to β-Globin Gene Expression Blood. 91: 2259-2263. DOI: 10.1182/Blood.V91.7.2259.2259_2259_2263  1
1997 Orkin SH, Zon LI. Genetics of erythropoiesis: Induced mutations in mice and zebrafish Annual Review of Genetics. 31: 33-60. PMID 9442889 DOI: 10.1146/Annurev.Genet.31.1.33  1
1997 Visvader JE, Mao X, Fujiwara Y, Hahm K, Orkin SH. The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. Proceedings of the National Academy of Sciences of the United States of America. 94: 13707-12. PMID 9391090 DOI: 10.1073/Pnas.94.25.13707  1
1997 Qu C, Shi ZQ, Shen R, Tsai FY, Orkin SH, Feng GS. A Deletion Mutation in the SH2-N Domain of Shp-2 Severely Suppresses Hematopoietic Cell Development Molecular and Cellular Biology. 17: 5499-5507. PMID 9271425 DOI: 10.1128/Mcb.17.9.5499  0.48
1997 Wang LC, Kuo F, Fujiwara Y, Gilliland DG, Golub TR, Orkin SH. Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL. The Embo Journal. 16: 4374-83. PMID 9250681 DOI: 10.1093/Emboj/16.14.4374  1
1997 Tsang AP, Visvader JE, Turner CA, Fujiwara Y, Yu C, Weiss MJ, Crossley M, Orkin SH. FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. Cell. 90: 109-19. PMID 9230307 DOI: 10.1016/S0092-8674(00)80318-9  1
1997 Tsai FY, Orkin SH. Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation Blood. 89: 3636-3643. PMID 9160668 DOI: 10.1182/Blood.V89.10.3636.3636_3636_3643  1
1997 Lien LL, Lee Y, Orkin SH. Regulation of the myeloid-cell-expressed human gp91-phox gene as studied by transfer of yeast artificial chromosome clones into embryonic stem cells: Suppression of a variegated cellular pattern of expression requires a full complement of distant cis elements Molecular and Cellular Biology. 17: 2279-2290. PMID 9121478 DOI: 10.1128/Mcb.17.4.2279  1
1997 Weiss MJ, Yu C, Orkin SH. Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line. Molecular and Cellular Biology. 17: 1642-51. PMID 9032291 DOI: 10.1128/Mcb.17.3.1642  1
1997 Strauss EC, Orkin SH. Guanine-adenine ligation-mediated PCR in vivo footprinting Methods: a Companion to Methods in Enzymology. 11: 164-170. PMID 8993028 DOI: 10.1006/Meth.1996.0402  1
1997 Strauss EC, Orkin SH. Analysis of the GATA-1 Gene Promoter and Globin Locus Control Region Elements by in Vivo Footprinting Advances in Molecular and Cell Biology. 21: 135-158. DOI: 10.1016/S1569-2558(08)60285-4  1
1996 Orkin SH. Development of the hematopoietic system Current Opinion in Genetics and Development. 6: 597-602. PMID 8939717 DOI: 10.1016/S0959-437X(96)80089-X  1
1996 Fujiwara Y, Browne CP, Cunniff K, Goff SC, Orkin SH. Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proceedings of the National Academy of Sciences of the United States of America. 93: 12355-8. PMID 8901585 DOI: 10.1073/Pnas.93.22.12355  1
1996 Perkins AC, Gaensler KML, Orkin SH. Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF. Proceedings of the National Academy of Sciences of the United States of America. 93: 12267-12271. PMID 8901569 DOI: 10.1073/Pnas.93.22.12267  1
1996 Peters LL, Shivdasani RA, Liu SC, Hanspal M, John KM, Gonzalez JM, Brugnara C, Gwynn B, Mohandas N, Alper SL, Orkin SH, Lux SE. Anion exchanger 1 (band 3) is required to prevent erythrocyte membrane surface loss but not to form the membrane skeleton Cell. 86: 917-927. PMID 8808627 DOI: 10.1016/S0092-8674(00)80167-1  1
1996 Kieran MW, Perkins AC, Orkin SH, Zon LI. Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor. Proceedings of the National Academy of Sciences of the United States of America. 93: 9126-31. PMID 8799165 DOI: 10.1073/Pnas.93.17.9126  1
1996 Crossley M, Whitelaw E, Perkins A, Williams G, Fujiwara Y, Orkin SH. Isolation And Characterization Of The Cdna Encoding Bklf/Tef-2, A Major Caccc-Box-Binding Protein In Erythroid Cells And Selected Other Cells Molecular and Cellular Biology. 16: 1695-1705. PMID 8657145 DOI: 10.1128/Mcb.16.4.1695  1
1996 Blobel GA, Orkin SH. Estrogen-induced apoptosis by inhibition of the erythroid transcription factor GATA-1 Molecular and Cellular Biology. 16: 1687-1694. PMID 8657144 DOI: 10.1128/Mcb.16.4.1687  1
1996 Field SJ, Tsai FY, Kuo F, Zubiaga AM, Kaelin WG, Livingston DM, Orkin SH, Greenberg ME. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell. 85: 549-61. PMID 8653790 DOI: 10.1016/S0092-8674(00)81255-6  1
1996 Shivdasani RA, Orkin SH. The transcriptional control of hematopoiesis Blood. 87: 4025-4039. PMID 8639758 DOI: 10.1182/Blood.V87.10.4025.Bloodjournal87104025  1
1996 Kotkow KJ, Orkin SH. Complexity of the erythroid transcription factor NF-E2 as revealed by gene targeting of the mouse p18 NF-E2 locus Proceedings of the National Academy of Sciences of the United States of America. 93: 3514-3518. PMID 8622968 DOI: 10.1073/Pnas.93.8.3514  1
1996 Weiss MJ, Orkin SH. In vitro differentiation of murine embryonic stem cells: New approaches to old problems Journal of Clinical Investigation. 97: 591-595. PMID 8609212 DOI: 10.1172/Jci118454  1
1996 Weiss MJ, Orkin SH. In vitro differentiation of murine embryonic stem cells new approaches to old problems Journal of Clinical Investigation. 98.  1
1995 Orkin SH. Hematopoiesis: how does it happen? Current Opinion in Cell Biology. 7: 870-877. PMID 8608018 DOI: 10.1016/0955-0674(95)80072-7  1
1995 Orkin SH. Transcription factors and hematopoietic development Journal of Biological Chemistry. 270: 4955-4958. PMID 7890597 DOI: 10.1074/Jbc.270.10.4955  1
1995 Shivdasanl RA, Mayer EL, Orkin SH. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL Nature. 373: 432-434. PMID 7830794 DOI: 10.1038/373432A0  0.32
1995 Weiss MJ, Orkin SH. GATA transcription factors: Key regulators of hematopoiesis Experimental Hematology. 23: 99-107. PMID 7828675  1
1995 Visvader JE, Crossley M, Hill J, Orkin SH, Adams JM. The C-terminal zinc finger of GATA-1 or GATA-2 is sufficient to induce megakaryocytic differentiation of an early myeloid cell line. Molecular and Cellular Biology. 15: 634-41. PMID 7823932 DOI: 10.1128/Mcb.15.2.634  1
1995 Blobel GA, Simon MC, Orkin SH. Rescue of GATA-1-deficient embryonic stem cells by heterologous GATA- binding proteins Molecular and Cellular Biology. 15: 626-633. PMID 7823931 DOI: 10.1128/Mcb.15.2.626  1
1995 Blobel GA, Sieff CA, Orkin SH. Ligand-dependent repression of the erythroid transcription factor GATA-1 by the estrogen receptor Molecular and Cellular Biology. 15: 3147-3153. PMID 7760810 DOI: 10.1128/Mcb.15.6.3147  1
1995 Parkins AC, Sharpe AH, Orkin SH. Lethal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF Nature. 375: 318-322. PMID 7753195 DOI: 10.1038/375318A0  1
1995 Crossley M, Merika M, Orkin SH. Self-association of the erythroid transcription factor GATA-1 mediated by its zinc finger domains Molecular and Cellular Biology. 15: 2448-2456. PMID 7739529 DOI: 10.1128/Mcb.15.5.2448  1
1995 Merika M, Orkin SH. Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Kruppel family proteins Sp1 and EKLF Molecular and Cellular Biology. 15: 2437-2447. PMID 7739528 DOI: 10.1128/Mcb.15.5.2437  1
1995 Chui DHK, Tang W, Orkin SH. cDNA cloning of murine Nrf 2 gene, coding for a p45 NF-E2 related transcription factor Biochemical and Biophysical Research Communications. 209: 40-46. PMID 7726861 DOI: 10.1006/Bbrc.1995.1467  1
1995 Skoda RC, Tsai SF, Orkin SH, Leder P. Expression of c-MYC under the control of GATA-1 regulatory sequences causes erythroleukemia in transgenic mice. The Journal of Experimental Medicine. 181: 1603-13. PMID 7722440 DOI: 10.1084/Jem.181.5.1603  1
1995 Orkin SH. Regulation of globin gene expression in erythroid cells European Journal of Biochemistry. 231: 271-281. PMID 7635138 DOI: 10.1111/J.1432-1033.1995.0271E.X  1
1995 Kotkow KJ, Orkin SH. Dependence of globin gene expression in mouse erythroleukemia cells on the NF-E2 heterodimer Molecular and Cellular Biology. 15: 4640-4647. PMID 7623856 DOI: 10.1128/Mcb.15.8.4640  1
1995 Weiss MJ, Orkin SH. Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis Proceedings of the National Academy of Sciences of the United States of America. 92: 9623-9627. PMID 7568185 DOI: 10.1073/Pnas.92.21.9623  1
1995 Shivdasani RA, Orkin SH. Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2 Proceedings of the National Academy of Sciences of the United States of America. 92: 8690-8694. PMID 7567998 DOI: 10.1073/Pnas.92.19.8690  1
1995 Lewis BA, Orkin SH. A functional initiator element in the human β-globin promoter Journal of Biological Chemistry. 270: 28139-28144. PMID 7499303 DOI: 10.1074/Jbc.270.47.28139  1
1994 Andrews NC, Orkin SH. Transcriptional control of erythropoiesis Current Opinion in Hematology. 1: 119-124. PMID 9371270  1
1994 Crossley M, Orkin SH. Phosphorylation of the erythroid transcription factor GATA-1 Journal of Biological Chemistry. 269: 16589-16596. PMID 8206977  1
1994 Crossley M, Tsang AP, Bieker JJ, Orkin SH. Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1 Journal of Biological Chemistry. 269: 15440-15444. PMID 8195185  1
1994 Gessler M, König A, Arden K, Grundy P, Orkin S, Sallan S, Peters C, Ruyle S, Mandell J, Li F, Cavenee W, Bruns G. Infrequent mutation of the WT1 gene in 77 Wilms' tumors Human Mutation. 3: 212-222. PMID 8019557 DOI: 10.1002/Humu.1380030307  1
1994 Weiss MJ, Keller G, Orkin SH. Novel insights into erythroid development revealed through in vitro differentiation of GATA-1- embryonic stem cells Genes and Development. 8: 1184-1197. PMID 7926723 DOI: 10.1101/Gad.8.10.1184  1
1994 Aufiero B, Neufeld EJ, Orkin SH. Sequence-specific DNA binding of individual cut repeats of the human CCAAT displacement/cut homeodomain protein Proceedings of the National Academy of Sciences of the United States of America. 91: 7757-7761. PMID 7914370 DOI: 10.1073/Pnas.91.16.7757  1
1994 Zhang R, Tsai FY, Orkin SH. Hematopoietic development of vav-/- mouse embryonic stem cells Proceedings of the National Academy of Sciences of the United States of America. 91: 12755-12759. PMID 7809116 DOI: 10.1073/Pnas.91.26.12755  1
1993 Zon LI, Yamaguchi Y, Yee K, Albee EA, Kimura A, Bennett JC, Orkin SH, Ackerman SJ. Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription. Blood. 81: 3234-41. PMID 8507862 DOI: 10.1182/Blood.V81.12.3234.Bloodjournal81123234  1
1993 Crossley M, Orkin SH. Regulation of the β-globin locus Current Opinion in Genetics and Development. 3: 232-237. PMID 8504248 DOI: 10.1016/0959-437X(93)90028-N  1
1993 Scherer SW, Neufeld EJ, Lievens P, Orkin SH, Kim J, Tsui LC. Regional localization of the CCAAT displacement protein gene (CUTL1) to 7q22 by analysis of somatic cell hybrids Genomics. 15: 695-696. PMID 8468066 DOI: 10.1006/Geno.1993.1130  1
1993 Arceci RJ, King AA, Simon MC, Orkin SH, Wilson DB. Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Molecular and Cellular Biology. 13: 2235-46. PMID 8455608 DOI: 10.1128/Mcb.13.4.2235  0.36
1993 Ney PA, Andrews NC, Jane SM, Safer B, Purucker ME, Weremowicz S, Morton CC, Goff SC, Orkin SH, Nienhuis AW. Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner. Molecular and Cellular Biology. 13: 5604-12. PMID 8355703 DOI: 10.1128/Mcb.13.9.5604  1
1993 Kreider BL, Orkin SH, Ihle JN. Loss of erythropoietin responsiveness in erythroid progenitors due to expression of the Evi-1 myeloid-transforming gene Proceedings of the National Academy of Sciences of the United States of America. 90: 6454-6458. PMID 8341654 DOI: 10.1073/Pnas.90.14.6454  1
1993 Merika M, Orkin SH. DNA-binding specificity of GATA family transcription factors Molecular and Cellular Biology. 13: 3999-4010. PMID 8321207 DOI: 10.1128/Mcb.13.7.3999  1
1993 Andrews NC, Kotkow KJ, Ney PA, Erdjument-Bromage H, Tempst P, Orkin SH. The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene Proceedings of the National Academy of Sciences of the United States of America. 90: 11488-11492. PMID 8265578 DOI: 10.1073/Pnas.90.24.11488  1
1993 Bodine DM, Moritz T, Donahue RE, Luskey BD, Kessler SW, Martin DI, Orkin SH, Nienhuis AW, Williams DA. Long-term in vivo expression of a murine adenosine deaminase gene in rhesus monkey hematopoietic cells of multiple lineages after retroviral mediated gene transfer into CD34+ bone marrow cells. Blood. 82: 1975-80. PMID 7691243 DOI: 10.1182/Blood.V82.7.1975.Bloodjournal8271975  1
1992 Orkin SH. GATA-binding transcription factors in hematopoietic cells Blood. 80: 575-581. PMID 1638017 DOI: 10.1182/Blood.V80.3.575.Bloodjournal803575  1
1992 Sposi NM, Zon LI, Carè A, Valtieri M, Testa U, Gabbianelli M, Mariani G, Bottero L, Mather C, Orkin SH. Cell cycle-dependent initiation and lineage-dependent abrogation of GATA-1 expression in pure differentiating hematopoietic progenitors. Proceedings of the National Academy of Sciences of the United States of America. 89: 6353-7. PMID 1631130 DOI: 10.1073/Pnas.89.14.6353  1
1992 Strauss EC, Orkin SH. In vivo protein-DNA interactions at hypersensitive site 3 of the human β- globin locus control region Proceedings of the National Academy of Sciences of the United States of America. 89: 5809-5813. PMID 1631062 DOI: 10.1073/Pnas.89.13.5809  1
1992 Zon LI, Orkin SH. Sequence of the human GATA-1 promoter Nucleic Acids Research. 20: 1812. PMID 1579480 DOI: 10.1093/Nar/20.7.1812  1
1992 Aplan PD, Nakahara K, Orkin SH, Kirsch IR. The SCL gene product: A positive regulator of erythroid differentiation Embo Journal. 11: 4073-4081. PMID 1396592 DOI: 10.1002/J.1460-2075.1992.Tb05500.X  1
1992 Neufeld EJ, Skalnik DG, Lievens PMJ, Orkin SH. Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut Nature Genetics. 1: 50-55. PMID 1301999 DOI: 10.1038/Ng0492-50  1
1991 Tsai SF, Strauss E, Orkin SH. Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter Genes and Development. 5: 919-931. PMID 2044960 DOI: 10.1101/Gad.5.6.919  1
1991 Pevny L, Simon MC, Robertson E, Klein WH, Tsai SF, D'Agati V, Orkin SH, Costantini F. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature. 349: 257-60. PMID 1987478 DOI: 10.1038/349257A0  1
1991 Zon LI, Mather C, Burgess S, Bolce ME, Harland RM, Orkin SH. Expression of GATA-binding proteins during embryonic development in Xenopus laevis. Proceedings of the National Academy of Sciences of the United States of America. 88: 10642-6. PMID 1961730 DOI: 10.1073/Pnas.88.23.10642  1
1991 Skalnik DG, Strauss EC, Orkin SH. CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter Journal of Biological Chemistry. 266: 16736-16744. PMID 1885602  1
1991 Marsden PA, Dorfman DM, Collins T, Brenner BM, Orkin SH, Ballermann BJ. Regulated expression of endothelin 1 in glomerular capillary endothelial cells American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 261. PMID 1858892 DOI: 10.1152/Ajprenal.1991.261.1.F117  1
1991 Ho IC, Vorhees P, Marin N, Oakley BK, Tsai SF, Orkin SH, Leiden JM. Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene. The Embo Journal. 10: 1187-92. PMID 1827068 DOI: 10.1002/J.1460-2075.1991.Tb08059.X  1
1991 Dinauer MC, Pierce EA, Erickson RW, Muhlebach TJ, Messner H, Orkin SH, Seger RA, Curnutte JT. Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous disease. Proceedings of the National Academy of Sciences of the United States of America. 88: 11231-5. PMID 1763037 DOI: 10.1073/Pnas.88.24.11231  1
1991 Zon LI, Gurish MF, Stevens RL, Mather C, Reynolds DS, Austen KF, Orkin SH. GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. The Journal of Biological Chemistry. 266: 22948-53. PMID 1744088  1
1991 Zon LI, Youssoufian H, Mather C, Lodish HF, Orkin SH. Activation of the erythropoietin receptor promoter by transcription factor GATA-1. Proceedings of the National Academy of Sciences of the United States of America. 88: 10638-41. PMID 1660143 DOI: 10.1073/Pnas.88.23.10638  1
1991 Skalnik DG, Dorfman DM, Perkins AS, Jenkins NA, Copeland NG, Orkin SH. Targeting of transgene expression to monocyte/macrophages by the gp91-phox promoter and consequent histiocytic malignancies Proceedings of the National Academy of Sciences of the United States of America. 88: 8505-8509. PMID 1656446 DOI: 10.1073/Pnas.88.19.8505  1
1991 Skalnik DG, Dorfman DM, Williams DA, Orkin SH. Restriction of neuroblastoma to the prostate gland in transgenic mice Molecular and Cellular Biology. 11: 4518-4527. PMID 1652058 DOI: 10.1128/Mcb.11.9.4518  1
1990 Wilson DB, Dorfman DM, Orkin SH. A nonerythroid GATA-binding protein is required for function of the human preproendothelin-1 promoter in endothelial cells Molecular and Cellular Biology. 10: 4854-4862. PMID 2388628 DOI: 10.1128/Mcb.10.9.4854  1
1990 Martin DI, Zon LI, Mutter G, Orkin SH. Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages. Nature. 344: 444-7. PMID 2320112 DOI: 10.1038/344444A0  1
1990 Mendoza AE, Young R, Orkin SH, Collins T. Increased platelet-derived growth factor A-chain expression in human uterine smooth muscle cells during the physiologic hypertrophy of pregnancy. Proceedings of the National Academy of Sciences of the United States of America. 87: 2177-81. PMID 2315311 DOI: 10.1073/Pnas.87.6.2177  1
1990 Zon LI, Tsai SF, Burgess S, Matsudaira P, Bruns GAP, Orkin SH. The major human erythroid DNA-binding protein (GF-1): Primary sequence and localization of the gene to the X chromosome Proceedings of the National Academy of Sciences of the United States of America. 87: 668-672. PMID 2300555 DOI: 10.1073/Pnas.87.2.668  1
1990 Martin DIK, Orkin SH. Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1 Genes and Development. 4: 1886-1898. PMID 2276623 DOI: 10.1101/Gad.4.11.1886  1
1990 Orkin SH. Preparing for the next generation: Presidential address to the American Society for Clinical Investigation, Washington, DC, 7 May 1990 Journal of Clinical Investigation. 86: 1773-1776. PMID 2254443 DOI: 10.1172/Jci114905  1
1990 Dinauer MC, Pierce EA, Bruns GA, Curnutte JT, Orkin SH. Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease. The Journal of Clinical Investigation. 86: 1729-37. PMID 2243141 DOI: 10.1172/Jci114898  1
1990 Young RM, Mendoza AE, Collins T, Orkin SH. Alternatively spliced platelet-derived growth factor A-chain transcripts are not tumor specific but encode normal cellular proteins. Molecular and Cellular Biology. 10: 6051-4. PMID 2233732 DOI: 10.1128/Mcb.10.11.6051  1
1990 Orkin SH. Globin gene regulation and switching: Circa 1990 Cell. 63: 665-672. PMID 2225071 DOI: 10.1016/0092-8674(90)90133-Y  1
1990 Youssoufian H, Zon LI, Orkin SH, D'Andrea AD, Lodish HF. Structure and transcription of the mouse erythropoietin receptor gene. Molecular and Cellular Biology. 10: 3675-82. PMID 2162479 DOI: 10.1128/Mcb.10.7.3675  1
1990 Orkin SH. Cell-specific transcription and cell differentiation in the erythroid lineage Current Opinion in Cell Biology. 2: 1003-1012. PMID 1966005 DOI: 10.1016/0955-0674(90)90149-9  1
1990 Whitelaw E, Tsai SF, Hogben P, Orkin SH. Regulated expression of globin chains and the erythroid transcription factor GATA-1 during erythropoiesis in the developing mouse Molecular and Cellular Biology. 10: 6596-6606. PMID 1701019 DOI: 10.1128/Mcb.10.12.6596  1
1989 Hirschhorn R, Tzall S, Ellenbogen A, Orkin SH. Identification of a point mutation resulting in a heat-labile adenosine deaminase (ADA) in two unrelated children with partial ADA deficiency Journal of Clinical Investigation. 83: 497-501. PMID 2783588 DOI: 10.1172/Jci113909  1
1989 Wise RJ, Orkin SH, Collins T. Aberrant expression of platelet-derived growth factor a-chaln cDNAs due to cryptic spiking of RNA transcripts in COS-1 cells Nucleic Acids Research. 17: 6591-6601. PMID 2780289 DOI: 10.1093/Nar/17.16.6591  1
1989 Tsai SF, Martin DI, Zon LI, D'Andrea AD, Wong GG, Orkin SH. Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature. 339: 446-51. PMID 2725678 DOI: 10.1038/339446A0  1
1989 Parkos CA, Dinauer MC, Jesaitis AJ, Orkin SH, Curnutte JT. Absence of both the 91kD and 22kD subunits of human neutrophil cytochrome b in two genetic forms of chronic granulomatous disease Blood. 73: 1416-1420. PMID 2713485 DOI: 10.1182/Blood.V73.6.1416.Bloodjournal7361416  1
1989 Zon LI, Dorfman DM, Orkin SH. The polymerase chain reaction colony miniprep Biotechniques. 7: 696-698. PMID 2631784  1
1989 Lim B, Apperley JF, Orkin SH, Williams DA. Long-term expression of human adenosine deaminase in mice transplanted with retrovirus-infected hematopoietic stem cells Proceedings of the National Academy of Sciences of the United States of America. 86: 8892-8896. PMID 2573068 DOI: 10.1073/Pnas.86.22.8892  1
1989 Dinauer MC, Curnutte JT, Rosen H, Orkin SH. A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome-positive X-linked chronic granulomatous disease Journal of Clinical Investigation. 84: 2012-2016. PMID 2556453 DOI: 10.1172/Jci114393  1
1989 Dorfman DM, Zon LI, Orkin SH. Rapid amplification of lambda gt11 bacteriophage library inserts from plaques using the polymerase chain reaction (PCR) Biotechniques. 7. PMID 2534350  1
1989 Orkin SH. Molecular genetics of chronic granulomatous disease Annual Review of Immunology. 7: 277-307. PMID 2523713 DOI: 10.1146/Annurev.Iy.07.040189.001425  1
1989 Quinn MT, Parkos CA, Walker L, Orkin SH, Dinauer MC, Jesaitis AJ. Association of a Ras-related protein with cytochrome b of human neutrophils Nature. 342: 198-200. PMID 2509942 DOI: 10.1038/342198A0  1
1989 Orkin SH. X-linked chronic granulomatous disease: More than two years later Molecular Biology and Medicine. 6: 1-5. PMID 2502702  1
1989 Martin DI, Orkin SH. An erythroid-specific DNA binding factor mediates increased gamma-globin expression in hereditary persistence of fetal hemoglobin (HPFH) Progress in Clinical and Biological Research. 316: 217-228. PMID 2480608  1
1989 Miller BA, Salameh M, Ahmed M, Olivieri N, Huisman THJ, Orkin SH, Nathan DG. Saudi Arabian sickle cell anemia. A molecular approach Annals of the New York Academy of Sciences. 565: 143-151. PMID 2476059 DOI: 10.1111/J.1749-6632.1989.Tb24161.X  1
1989 Martin DIK, Tsai SF, Orkin SH. Increased γ-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA-binding factor Nature. 338: 435-438. PMID 2467208 DOI: 10.1038/338435A0  1
1988 Collins T, Bonthron DT, Orkin SH. Alternative RNA splicing affects function of encoded platelet-derived growth factor A chain Nature. 328: 621-624. PMID 3614364 DOI: 10.1038/328621A0  1
1988 Bonthron DT, Morton CC, Orkin SH, Collins T. Platelet-derived growth factor A chain: Gene structure, chromosomal location, and basis for alternative mRNA splicing Proceedings of the National Academy of Sciences of the United States of America. 85: 1492-1496. PMID 3422746 DOI: 10.1073/Pnas.85.5.1492  1
1988 Parkos CA, Dinauer MC, Walker LE, Allen RA, Jesaitis AJ, Orkin SH. Primary structure and unique expression of the 22-kilodalton light chain of human neutrophil cytochrome b Proceedings of the National Academy of Sciences of the United States of America. 85: 3319-3323. PMID 3368442 DOI: 10.1073/Pnas.85.10.3319  1
1988 Dinauer MC, Orkin SH. Chronic granulomatous disease. Molecular genetics Hematology/Oncology Clinics of North America. 2: 225-240. PMID 3292508  1
1988 Orkin SH, Williams DA. Gene therapy of somatic cells: status and prospects Progress in Medical Genetics. 7: 130-142. PMID 3277251  1
1988 Barker KA, Orkin SH, Newburger PE. Expression of the X-CGD gene during induced differentiation of myeloid leukemia cell line HL-60. Molecular and Cellular Biology. 8: 2804-10. PMID 3165493 DOI: 10.1128/Mcb.8.7.2804  1
1988 Bonthron D, Orkin SH. The human von Willebrand factor gene. Structure of the 5' region European Journal of Biochemistry. 171: 51-57. PMID 2828057 DOI: 10.1111/J.1432-1033.1988.Tb13757.X  1
1987 Lim B, Williams DA, Orkin SH. Retrovirus-mediated gene transfer of human adenosine deaminase: expression of functional enzyme in murine hematopoietic stem cells in vivo Molecular and Cellular Biology. 7: 3459-3465. PMID 3683389 DOI: 10.1128/Mcb.7.10.3459  1
1987 Orkin SH. Genetic diagnosis by DNA analysis: progress through amplification New England Journal of Medicine. 317: 1023-1025. PMID 3657858 DOI: 10.1056/Nejm198710153171609  1
1987 Dinauer MC, Orkin SH, Brown R, Jesaitis AJ, Parkos CA. The glycoprotein encoded by the X-linked chronic granulomatous disease locus is a component of the neutrophil cytochrome b complex Nature. 327: 717-720. PMID 3600768 DOI: 10.1038/327717A0  1
1987 Williams DA, Lim B, Orkin SH. Transfer and expression of human ADA in murine hematopoietic stem cells Progress in Clinical and Biological Research. 251: 567-580. PMID 3432278  1
1987 Orkin SH. "Forward" and "reverse" genetics of inherited human disorders: the thalassemia syndromes and chronic granulomatous disease Harvey Lectures. 83: 57-76. PMID 3334140  1
1987 Wojchowski DM, Orkin SH, Sytkowski AJ. Active human erythropoietin expressed in insect cells using a baculovirus vector: A role for N-linked oligosaccharide Bba - Gene Structure and Expression. 910: 224-232. PMID 2960381 DOI: 10.1016/0167-4781(87)90114-X  1
1987 Ezekowitz RAB, Orkin SH, Newburger PE. Recombinant interferon gamma augments phagocyte superoxide production and X-chronic granulomatous disease gene expression in X-linked variant chronic granulomatous disease Journal of Clinical Investigation. 80: 1009-1016. PMID 2821069 DOI: 10.1172/Jci113153  1
1987 Miller BA, Olivieri N, Salameh M, Ahmed M, Antognetti G, Huisman TH, Nathan DG, Orkin SH. Molecular analysis of the high-hemoglobin-F phenotype in Saudi Arabian sickle cell anemia New England Journal of Medicine. 316: 244-250. PMID 2432426 DOI: 10.1056/Nejm198701293160504  1
1987 Orkin SH. The pitfalls of sequencing: revised sequence of the X-CGD gene Trends in Genetics. 3: 207. DOI: 10.1016/0168-9525(87)90236-8  1
1987 Orkin SH. X-linked chronic granulomatous disease: from chromosomal position to the in vivo gene product Trends in Genetics. 3: 149-151. DOI: 10.1016/0168-9525(87)90215-0  1
1987 Williams DA, Orkin SH. Molecular techniques in hematopoiesis: Retroviral-mediated gene transfer into hematopoietic stem cells Hematology Reviews and Communications. 2: 1-12.  1
1986 Orkin SH. Molecular genetics and potential gene therapy Clinical Immunology and Immunopathology. 40: 151-156. PMID 3521968 DOI: 10.1016/0090-1229(86)90080-2  1
1986 Williams DA, Orkin SH. Somatic gene therapy. Current status and future prospects Journal of Clinical Investigation. 77: 1053-1056. PMID 3514670 DOI: 10.1172/Jci112403  1
1986 Williams DA, Orkin SH, Mulligan RC. Retrovirus-mediated transfer of human adenosine deaminase gene sequences into cells in culture and into murine hematopoietic cells in vivo. Proceedings of the National Academy of Sciences of the United States of America. 83: 2566-70. PMID 3458218 DOI: 10.1073/Pnas.83.8.2566  1
1986 Baehner RL, Kunkel LM, Monaco AP, Haines JL, Conneally PM, Palmer C, Heerema N, Orkin SH. DNA linkage analysis of X chromosome-linked chronic granulomatous disease Proceedings of the National Academy of Sciences of the United States of America. 83: 3398-3401. PMID 3010296 DOI: 10.1073/Pnas.83.10.3398  1
1986 Orkin SH. Reverse genetics and human disease Cell. 47: 845-850. PMID 2430724 DOI: 10.1016/0092-8674(86)90799-3  1
1985 Collins T, Ginsburg D, Boss JM, Orkin SH, Pober JS. Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis Nature. 316: 748-750. PMID 4033772 DOI: 10.1038/316748A0  1
1985 Antonarakis SE, Kazazian HH, Orkin SH. DNA polymorphism and molecular pathology of the human globin gene clusters Human Genetics. 69: 1-14. PMID 3881334 DOI: 10.1007/Bf00295521  1
1985 Daddona PE, Orkin SH, Shewach DS, Kelley WN. cDNA and amino acid sequence of human adenosine deaminase. Annals of the New York Academy of Sciences. 451: 238-44. PMID 3878119 DOI: 10.1111/J.1749-6632.1985.Tb27114.X  1
1985 van Den Elsen P, Bruns G, Gerhard DS, Pravtcheva D, Jones C, Housman D, Ruddle FA, Orkin S, Terhorst C. Assignment of the gene coding for the T-3-δ subunit of the T3-T-cell receptor complex to the long arm of human chromosome 11 and to mouse chromosome 9 Proceedings of the National Academy of Sciences of the United States of America. 82: 2920-2924. PMID 3857625 DOI: 10.1073/Pnas.82.9.2920  1
1985 Orkin SH, Goff SC, Kelley WN, Daddona PE. Transient expression of human adenosine deaminase cDNAs: identification of a nonfunctional clone resulting from a single amino acid substitution. Molecular and Cellular Biology. 5: 762-7. PMID 3838797 DOI: 10.1128/Mcb.5.4.762  1
1985 Prochownik EV, Block SC, Orkin SH. Intron structure of the human antithrombin III gene differs from that of other members of the serine protease inhibitor superfamily Journal of Biological Chemistry. 260: 9608-9612. PMID 2991253  1
1984 Kazazian HH, Orkin SH, Markham AF, Chapman CR, Youssoufian H, Waber PG. Quantification of the close association between DNA haplotypes and specific β -thalassaemia mutations in Mediterraneans Nature. 310: 152-154. PMID 6738712 DOI: 10.1038/310152A0  1
1984 Orkin SH, Antonarakis SE, Loukopoulos D. Abnormal processing of β(Knossos) RNA Blood. 64: 311-313. PMID 6733281  1
1984 Cheng TC, Orkin SH, Antonarakis SE, Potter MJ, Sexton JP, Markham AF, Giardina PJ, Li A, Kazazian HH. beta-Thalassemia in Chinese: use of in vivo RNA analysis and oligonucleotide hybridization in systematic characterization of molecular defects. Proceedings of the National Academy of Sciences of the United States of America. 81: 2821-5. PMID 6585831 DOI: 10.1073/Pnas.81.9.2821  1
1984 Huebner K, Nagarajan L, deJesus E, Orkin SH, Caskey CT, Croce CM. Activity of X-linked genes in stem and differentiated Mus musculus X Mus caroli hybrid cells. Cell Differentiation. 15: 241-8. PMID 6543551 DOI: 10.1016/0045-6039(84)90081-2  1
1984 Orkin SH. Molecular analysis of human disease: Dissection of β-thalassemia Clinical Research. 32: 329-333. PMID 6488699  1
1984 Orkin SH, Goldman DS, Sallan SE. Development of homozygosity for chromosome 11p markers in Wilms' tumour Nature. 309: 172-174. PMID 6325937 DOI: 10.1038/309172A0  1
1984 Orkin SH. Prenatal diagnosis of hemoglobin disorders by DNA analysis Blood. 63: 249-253. PMID 6318864 DOI: 10.1182/Blood.V63.2.249.Bloodjournal632249  1
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