Stuart H. Orkin, M.D. - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 
Area:
Genetics, Molecular Biology, Neuroscience Biology
Website:
http://www.dfhcc.harvard.edu/insider/member-detail/member/stuart-h-orkin-md/

366 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Zhu Q, Liu N, Orkin SH, Yuan GC. CUT&RUNTools: a flexible pipeline for CUT&RUN processing and footprint analysis. Genome Biology. 20: 192. PMID 31500663 DOI: 10.1186/s13059-019-1802-4  0.52
2019 Debruyne DN, Dries R, Sengupta S, Seruggia D, Gao Y, Sharma B, Huang H, Moreau L, McLane M, Day DS, Marco E, Chen T, Gray NS, Wong KK, Orkin SH, et al. BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells. Nature. PMID 31391581 DOI: 10.1038/s41586-019-1472-0  0.8
2019 Sher F, Hossain M, Seruggia D, Schoonenberg VAC, Yao Q, Cifani P, Dassama LMK, Cole MA, Ren C, Vinjamur DS, Macias-Trevino C, Luk K, McGuckin C, Schupp PG, Canver MC, ... ... Orkin SH, et al. Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis. Nature Genetics. PMID 31253978 DOI: 10.1038/s41588-019-0453-4  1
2019 Seruggia D, Oti M, Tripathi P, Canver MC, LeBlanc L, Di Giammartino DC, Bullen MJ, Nefzger CM, Sun YBY, Farouni R, Polo JM, Pinello L, Apostolou E, Kim J, Orkin SH, et al. TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network. Molecular Cell. PMID 31005419 DOI: 10.1016/j.molcel.2019.03.025  1
2019 Jadhav U, Cavazza A, Banerjee KK, Xie H, O'Neill NK, Saenz-Vash V, Herbert Z, Madha S, Orkin SH, Zhai H, Shivdasani RA. Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA. Molecular Cell. PMID 30905509 DOI: 10.1016/j.molcel.2019.02.024  0.44
2018 Barros-Silva JD, Linn DE, Steiner I, Guo G, Ali A, Pakula H, Ashton G, Peset I, Brown M, Clarke NW, Bronson RT, Yuan GC, Orkin SH, Li Z, Baena E. Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer. Cell Reports. 25: 3504-3518.e6. PMID 30566873 DOI: 10.1016/j.celrep.2018.11.069  0.56
2018 LeBlanc L, Lee BK, Yu AC, Kim M, Kambhampati AV, Dupont SM, Seruggia D, Ryu BU, Orkin SH, Kim J. Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation. Elife. 7. PMID 30561326 DOI: 10.7554/eLife.40167  1
2018 Hsu JY, Fulco CP, Cole MA, Canver MC, Pellin D, Sher F, Farouni R, Clement K, Guo JA, Biasco L, Orkin SH, Engreitz JM, Lander ES, Joung JK, Bauer DE, et al. CRISPR-SURF: discovering regulatory elements by deconvolution of CRISPR tiling screen data. Nature Methods. 15: 992-993. PMID 30504875 DOI: 10.1038/s41592-018-0225-6  0.4
2018 Yien YY, Shi J, Chen C, Cheung JT, Grillo AS, Shrestha R, Li L, Zhang X, Kafina MD, Kingsley PD, King MJ, Ablain J, Li H, Zon L, Palis J, ... ... Orkin SH, et al. FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity. The Journal of Biological Chemistry. PMID 30366982 DOI: 10.1074/jbc.RA118.002742  1
2018 Singarapu N, Ma K, Reeh KAG, Shen J, Lancaster JN, Yi S, Xie H, Orkin SH, Manley NR, Ehrlich LIR, Jiang N, Richie ER. Polycomb Repressive Complex 2 is essential for development and maintenance of a functional TEC compartment. Scientific Reports. 8: 14335. PMID 30254371 DOI: 10.1038/s41598-018-32729-z  0.44
2018 Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour A, Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A, Arias E, Pinello L, Katz Y, Shinagare S, Abu-Remaileh M, Mihaylova MM, ... ... Orkin SH, et al. Author Correction: High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. PMID 29849139 DOI: 10.1038/s41586-018-0187-y  0.52
2018 MacLean GA, McEldoon J, Huang J, Allred J, Canver MC, Orkin SH. Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells. Scientific Reports. 8: 8001. PMID 29789608 DOI: 10.1038/s41598-018-26123-y  0.48
2018 Han X, Wang R, Zhou Y, Fei L, Sun H, Lai S, Saadatpour A, Zhou Z, Chen H, Ye F, Huang D, Xu Y, Huang W, Jiang M, Jiang X, ... ... Orkin SH, et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell. 173: 1307. PMID 29775597 DOI: 10.1016/j.cell.2018.05.012  0.52
2018 Lu TT, Heyne S, Dror E, Casas E, Leonhardt L, Boenke T, Yang CH, Sagar, Arrigoni L, Dalgaard K, Teperino R, Enders L, Selvaraj M, Ruf M, Raja SJ, ... ... Orkin SH, et al. The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes. Cell Metabolism. PMID 29754954 DOI: 10.1016/j.cmet.2018.04.013  0.44
2018 Canver MC, Haeussler M, Bauer DE, Orkin SH, Sanjana NE, Shalem O, Yuan GC, Zhang F, Concordet JP, Pinello L. Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments. Nature Protocols. 13: 946-986. PMID 29651054 DOI: 10.1038/nprot.2018.005  0.52
2018 Liu N, Hargreaves VV, Zhu Q, Kurland JV, Hong J, Kim W, Sher F, Macias-Trevino C, Rogers JM, Kurita R, Nakamura Y, Yuan GC, Bauer DE, Xu J, Bulyk ML, ... Orkin SH, et al. Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch. Cell. PMID 29606353 DOI: 10.1016/j.cell.2018.03.016  1
2018 Huang J, Li K, Cai W, Liu X, Zhang Y, Orkin SH, Xu J, Yuan GC. Dissecting super-enhancer hierarchy based on chromatin interactions. Nature Communications. 9: 943. PMID 29507293 DOI: 10.1038/s41467-018-03279-9  1
2018 Yamauchi T, Masuda T, Canver MC, Seiler M, Semba Y, Shboul M, Al-Raqad M, Maeda M, Schoonenberg VAC, Cole MA, Macias-Trevino C, Ishikawa Y, Yao Q, Nakano M, Arai F, ... Orkin SH, et al. Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS. Cancer Cell. PMID 29478914 DOI: 10.1016/j.ccell.2018.01.012  0.4
2018 Han X, Wang R, Zhou Y, Fei L, Sun H, Lai S, Saadatpour A, Zhou Z, Chen H, Ye F, Huang D, Xu Y, Huang W, Jiang M, Jiang X, ... ... Orkin SH, et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell. 172: 1091-1107.e17. PMID 29474909 DOI: 10.1016/j.cell.2018.02.001  0.52
2018 Vo LT, Kinney MA, Liu X, Zhang Y, Barragan J, Sousa PM, Jha DK, Han A, Cesana M, Shao Z, North TE, Orkin SH, Doulatov S, Xu J, Daley GQ. Regulation of embryonic haematopoietic multipotency by EZH1. Nature. PMID 29342143 DOI: 10.1038/nature25435  1
2017 Pittermann E, Lachmann N, MacLean G, Emmrich S, Ackermann M, Göhring G, Schlegelberger B, Welte K, Schambach A, Heckl D, Orkin SH, Cantz T, Klusmann JH. Gene correction of HAX1 reversed Kostmann disease phenotype in patient-specific induced pluripotent stem cells. Blood Advances. 1: 903-914. PMID 29296734 DOI: 10.1182/bloodadvances.2016003798  0.56
2017 Lessard S, Francioli L, Alfoldi J, Tardif JC, Ellinor PT, MacArthur DG, Lettre G, Orkin SH, Canver MC. Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci. Proceedings of the National Academy of Sciences of the United States of America. 114: E11257-E11266. PMID 29229813 DOI: 10.1073/pnas.1714640114  0.4
2017 Moody JD, Levy S, Mathieu J, Xing Y, Kim W, Dong C, Tempel W, Robitaille AM, Dang LT, Ferreccio A, Detraux D, Sidhu S, Zhu L, Carter L, Xu C, ... ... Orkin SH, et al. First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor. Proceedings of the National Academy of Sciences of the United States of America. PMID 28864533 DOI: 10.1073/pnas.1706907114  0.52
2017 Hsu JH, Hubbell-Engler B, Adelmant G, Huang J, Joyce CE, Vazquez F, Weir BA, Montgomery P, Tsherniak A, Giacomelli AO, Perry JA, Trowbridge J, Fujiwara Y, Cowley GS, Xie H, ... ... Orkin SH, et al. Prmt1-mediated translation regulation is a crucial vulnerability of cancer. Cancer Research. PMID 28655788 DOI: 10.1158/0008-5472.CAN-17-0216  1
2017 Han X, Yu H, Huang D, Xu Y, Saadatpour A, Li X, Wang L, Yu J, Pinello L, Lai S, Jiang M, Tian X, Zhang F, Cen Y, Fujiwara Y, ... ... Orkin SH, et al. A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations. Cell Research. 27: 843. PMID 28572571 DOI: 10.1038/cr.2017.78  1
2017 Han X, Yu H, Huang D, Xu Y, Saadatpour A, Li X, Wang L, Yu J, Pinello L, Lai S, Jiang M, Tian X, Zhang F, Cen Y, Fujiwara Y, ... ... Orkin SH, et al. A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations. Cell Research. 27: 842. PMID 28572570 DOI: 10.1038/cr.2017.77  1
2017 Chung J, Wittig JG, Ghamari A, Maeda M, Dailey TA, Bergonia H, Kafina MD, Coughlin EE, Minogue CE, Hebert AS, Li L, Kaplan J, Lodish HF, Bauer DE, Orkin SH, et al. Erythropoietin signaling regulates heme biosynthesis. Elife. 6. PMID 28553927 DOI: 10.7554/eLife.24767  1
2017 Xie Y, Koch ML, Zhang X, Hamblen MJ, Godinho FJ, Fujiwara Y, Xie H, Klusmann JH, Orkin SH, Li Z. Reduced Erg Dosage Impairs Survival of Hematopoietic Stem and Progenitor Cells. Stem Cells (Dayton, Ohio). PMID 28436588 DOI: 10.1002/stem.2627  1
2017 Ai S, Peng Y, Li C, Gu F, Yu X, Yue Y, Ma Q, Chen J, Lin Z, Zhou P, Xie H, Prendiville TW, Zheng W, Liu Y, Orkin SH, et al. EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent. Elife. 6. PMID 28394251 DOI: 10.7554/eLife.24570  0.52
2017 Canver MC, Bauer DE, Orkin SH. Functional interrogation of non-coding DNA through CRISPR genome editing. Methods (San Diego, Calif.). PMID 28288828 DOI: 10.1016/j.ymeth.2017.03.008  0.4
2017 Erb MA, Scott TG, Li BE, Xie H, Paulk J, Seo HS, Souza A, Roberts JM, Dastjerdi S, Buckley DL, Sanjana NE, Shalem O, Nabet B, Zeid R, Offei-Addo NK, ... ... Orkin SH, et al. Transcription control by the ENL YEATS domain in acute leukaemia. Nature. PMID 28241139 DOI: 10.1038/nature21688  0.44
2017 Canver MC, Lessard S, Pinello L, Wu Y, Ilboudo Y, Stern EN, Needleman AJ, Galactéros F, Brugnara C, Kutlar A, McKenzie C, Reid M, Chen DD, Das PP, A Cole M, ... ... Orkin SH, et al. Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci. Nature Genetics. PMID 28218758 DOI: 10.1038/ng.3793  0.52
2017 Canver MC, Bauer DE, Dass A, Yien YY, Chung J, Masuda T, Maeda T, Paw BH, Orkin SH. Characterization of genomic deletion efficiency mediated by clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells. The Journal of Biological Chemistry. 292: 2556. PMID 28188222 DOI: 10.1074/jbc.A114.564625  0.4
2017 Han X, Yu H, Huang D, Xu Y, Saadatpour A, Li X, Wang L, Yu J, Pinello L, Lai S, Jiang M, Tian X, Zhang F, Cen Y, Fujiwara Y, ... ... Orkin SH, et al. A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations. Cell Research. PMID 28128194 DOI: 10.1038/cr.2017.17  1
2016 Beyaz S, Kim JH, Pinello L, Xifaras ME, Hu Y, Huang J, Kerenyi MA, Das PP, Barnitz RA, Herault A, Dogum R, Haining WN, Yilmaz ÖH, Passegue E, Yuan GC, ... Orkin SH, et al. The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells. Nature Immunology. PMID 27992400 DOI: 10.1038/ni.3644  1
2016 Smith EC, Luc S, Croney DM, Woodworth MB, Greig LC, Fujiwara Y, Nguyen M, Sher F, Macklis JD, Bauer DE, Orkin SH. Strict in vivo specificity of the Bcl11a erythroid enhancer. Blood. PMID 27707736 DOI: 10.1182/blood-2016-08-736249  1
2016 Nelms BD, Waldron L, Barrera LA, Weflen AW, Goettel JA, Guo G, Montgomery RK, Neutra MR, Breault DT, Snapper SB, Orkin SH, Bulyk ML, Huttenhower C, Lencer WI. CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types. Genome Biology. 17: 201. PMID 27687735 DOI: 10.1186/s13059-016-1062-5  0.36
2016 Luc S, Huang J, McEldoon JL, Somuncular E, Li D, Rhodes C, Mamoor S, Hou S, Xu J, Orkin SH. Bcl11a Deficiency Leads to Hematopoietic Stem Cell Defects with an Aging-like Phenotype. Cell Reports. 16: 3181-94. PMID 27653684 DOI: 10.1016/j.celrep.2016.08.064  1
2016 Xie H, Peng C, Huang J, Li BE, Kim W, Smith EC, Fujiwara Y, Qi J, Cheloni G, Das PP, Nguyen M, Li S, Bradner JE, Orkin SH. Chronic myelogenous leukemia initiating cells require Polycomb group protein EZH2. Cancer Discovery. PMID 27630126 DOI: 10.1158/2159-8290.CD-15-1439  1
2016 Brendel C, Guda S, Renella R, Bauer DE, Canver MC, Kim YJ, Heeney MM, Klatt D, Fogel J, Milsom MD, Orkin SH, Gregory RI, Williams DA. Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype. The Journal of Clinical Investigation. 126: 3868-3878. PMID 27599293 DOI: 10.1172/JCI87885  0.4
2016 Kim TH, Saadatpour A, Guo G, Saxena M, Cavazza A, Desai N, Jadhav U, Jiang L, Rivera MN, Orkin SH, Yuan GC, Shivdasani RA. Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells. Cell Reports. PMID 27524622 DOI: 10.1016/j.celrep.2016.07.056  0.52
2016 Townsend EC, Murakami MA, Christodoulou A, Christie AL, Köster J, DeSouza TA, Morgan EA, Kallgren SP, Liu H, Wu SC, Plana O, Montero J, Stevenson KE, Rao P, Vadhi R, ... ... Orkin SH, et al. The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 30: 183. PMID 27479034 DOI: 10.1016/j.ccell.2016.06.008  1
2016 Pinello L, Canver MC, Hoban MD, Orkin SH, Kohn DB, Bauer DE, Yuan GC. Analyzing CRISPR genome-editing experiments with CRISPResso. Nature Biotechnology. 34: 695-697. PMID 27404874 DOI: 10.1038/nbt.3583  0.52
2016 Shimizu T, Kubovcakova L, Nienhold R, Zmajkovic J, Meyer SC, Hao-Shen H, Geier F, Dirnhofer S, Guglielmelli P, Vannucchi AM, Feenstra JD, Kralovics R, Orkin SH, Skoda RC. Loss of Ezh2 synergizes with JAK2-V617F in initiating myeloproliferative neoplasms and promoting myelofibrosis. The Journal of Experimental Medicine. PMID 27401344 DOI: 10.1084/jem.20151136  1
2016 Liddicoat BJ, Hartner JC, Piskol R, Ramaswami G, Chalk AM, Kingsley PD, Sankaran VG, Wall M, Purton LE, Seeburg PH, Palis J, Orkin SH, Lu J, Li JB, Walkley CR. Adenosine-to-insoine RNA editing by ADAR1 is essential for normal murine erythropoiesis. Experimental Hematology. PMID 27373493 DOI: 10.1016/j.exphem.2016.06.250  0.32
2016 Mirzamohammadi F, Papaioannou G, Inloes JB, Rankin EB, Xie H, Schipani E, Orkin SH, Kobayashi T. Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling. Nature Communications. 7: 12047. PMID 27329220 DOI: 10.1038/ncomms12047  0.44
2016 Jadhav U, Nalapareddy K, Saxena M, O'Neill NK, Pinello L, Yuan GC, Orkin SH, Shivdasani RA. Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells. Cell. PMID 27212235 DOI: 10.1016/j.cell.2016.04.031  0.32
2016 Kim PG, Canver MC, Rhee C, Ross SJ, Harriss JV, Tu HC, Orkin SH, Tucker HO, Daley GQ. Interferon-alpha signaling promotes embryonic HSC maturation. Blood. PMID 27095787 DOI: 10.1182/blood-2016-01-689281  1
2016 Kim J, Singh AK, Takata Y, Lin K, Shen J, Lu Y, Kerenyi MA, Orkin SH, Chen T. Corrigendum: LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice. Nature Communications. 7: 11467. PMID 27095451 DOI: 10.1038/ncomms11467  1
2016 Townsend EC, Murakami MA, Christodoulou A, Christie AL, Köster J, DeSouza TA, Morgan EA, Kallgren SP, Liu H, Wu SC, Plana O, Montero J, Stevenson KE, Rao P, Vadhi R, ... ... Orkin SH, et al. The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 29: 574-86. PMID 27070704 DOI: 10.1016/j.ccell.2016.03.008  1
2016 Canver MC, Orkin SH. Customizing the genome as therapy for the β-hemoglobinopathies. Blood. PMID 27053533 DOI: 10.1182/blood-2016-01-678128  0.4
2016 Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour A, Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A, Arias E, Pinello L, Katz Y, Shinagare S, Abu-Remaileh M, Mihaylova MM, ... ... Orkin SH, et al. High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. 531: 53-8. PMID 26935695 DOI: 10.1038/nature17173  0.52
2016 Danis E, Yamauchi T, Echanique K, Zhang X, Haladyna JN, Riedel SS, Zhu N, Xie H, Orkin SH, Armstrong SA, Bernt KM, Neff T. Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia. Cell Reports. PMID 26904942 DOI: 10.1016/j.celrep.2016.01.064  0.44
2016 Orkin SH. Recent advances in globin research using genome-wide association studies and gene editing. Annals of the New York Academy of Sciences. PMID 26866328 DOI: 10.1111/nyas.13001  1
2016 Masuda T, Wang X, Maeda M, Canver MC, Sher F, Funnell AP, Fisher C, Suciu M, Martyn GE, Norton LJ, Zhu C, Kurita R, Nakamura Y, Xu J, Higgs DR, ... ... Orkin SH, et al. Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin. Science (New York, N.Y.). 351: 285-9. PMID 26816381 DOI: 10.1126/science.aad3312  0.48
2016 Guo G, Pinello L, Han X, Lai S, Shen L, Lin TW, Zou K, Yuan GC, Orkin SH. Serum-Based Culture Conditions Provoke Gene Expression Variability in Mouse Embryonic Stem Cells as Revealed by Single-Cell Analysis. Cell Reports. PMID 26804902 DOI: 10.1016/j.celrep.2015.12.089  1
2016 Huang J, Liu X, Li D, Shao Z, Cao H, Zhang Y, Trompouki E, Bowman TV, Zon LI, Yuan GC, Orkin SH, Xu J. Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis. Developmental Cell. 36: 9-23. PMID 26766440 DOI: 10.1016/j.devcel.2015.12.014  1
2015 De Los Angeles A, Ferrari F, Fujiwara Y, Mathieu R, Lee S, Lee S, Tu HC, Ross S, Chou S, Nguyen M, Wu Z, Theunissen TW, Powell BE, Imsoonthornruksa S, Chen J, ... ... Orkin SH, et al. Corrigendum: Failure to replicate the STAP cell phenomenon. Nature. PMID 26675720 DOI: 10.1038/nature16479  1
2015 Yin J, Leavenworth JW, Li Y, Luo Q, Xie H, Liu X, Huang S, Yan H, Fu Z, Zhang LY, Zhang L, Hao J, Wu X, Deng X, Roberts CW, ... Orkin SH, et al. Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 26668377 DOI: 10.1073/pnas.1521740112  0.48
2015 Kim J, Singh AK, Takata Y, Lin K, Shen J, Lu Y, Kerenyi MA, Orkin SH, Chen T. LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice. Nature Communications. 6: 10116. PMID 26626423 DOI: 10.1038/ncomms10116  1
2015 Kim KH, Kim W, Howard TP, Vazquez F, Tsherniak A, Wu JN, Wang W, Haswell JR, Walensky LD, Hahn WC, Orkin SH, Roberts CW. SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2. Nature Medicine. PMID 26552009 DOI: 10.1038/nm.3968  0.52
2015 De Los Angeles A, Ferrari F, Fujiwara Y, Mathieu R, Lee S, Lee S, Tu HC, Ross S, Chou S, Nguyen M, Wu Z, Theunissen TW, Powell BE, Imsoonthornruksa S, Chen J, ... ... Orkin SH, et al. Failure to replicate the STAP cell phenomenon. Nature. 525: E6-9. PMID 26399835 DOI: 10.1038/nature15513  1
2015 Anderson H, Patch TC, Reddy PN, Hagedorn EJ, Kim PG, Soltis KA, Chen MJ, Tamplin OJ, Frye M, MacLean GA, Hübner K, Bauer DE, Kanki JP, Vogin G, Huston NC, ... ... Orkin SH, et al. Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression. Blood. PMID 26385351 DOI: 10.1182/blood-2015-07-659276  1
2015 Bauer DE, Orkin SH. Hemoglobin switching's surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin. Current Opinion in Genetics & Development. 33: 62-70. PMID 26375765 DOI: 10.1016/j.gde.2015.08.001  1
2015 Canver MC, Smith EC, Sher F, Pinello L, Sanjana NE, Shalem O, Chen DD, Schupp PG, Vinjamur DS, Garcia SP, Luc S, Kurita R, Nakamura Y, Fujiwara Y, Maeda T, ... ... Orkin SH, et al. BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis. Nature. PMID 26375006 DOI: 10.1038/nature15521  1
2015 Renneville A, Van Galen P, Canver MC, McConkey M, Krill-Burger JM, Dorfman DM, Holson EB, Bernstein BE, Orkin SH, Bauer DE, Ebert BL. EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression. Blood. 126: 1930-9. PMID 26320100 DOI: 10.1182/blood-2015-06-649087  1
2015 Das PP, Hendrix DA, Apostolou E, Buchner AH, Canver MC, Beyaz S, Ljuboja D, Kuintzle R, Kim W, Karnik R, Shao Z, Xie H, Xu J, De Los Angeles A, Zhang Y, ... ... Orkin SH, et al. PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells. Cell Reports. 12: 1456-1470. PMID 26299972 DOI: 10.1016/j.celrep.2015.07.053  1
2015 Danis E, Yamauchi T, Echanique K, Haladyna J, Kalkur R, Riedel S, Zhu N, Xie H, Bernt KM, Orkin SH, Armstrong SA, Neff T. Inactivation of Eed Impedes MLL-AF9 Mediated Leukemogenesis Through Cdkn2a-Dependent and Cdkn2a-Independent Mechanisms in a Murine Model. Experimental Hematology. PMID 26118502 DOI: 10.1016/j.exphem.2015.06.005  0.44
2015 Guda S, Brendel C, Renella R, Du P, Bauer DE, Canver MC, Grenier JK, Grimson AW, Kamran SC, Thornton J, de Boer H, Root DE, Milsom MD, Orkin SH, Gregory RI, et al. miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 1465-74. PMID 26080908 DOI: 10.1038/mt.2015.113  0.4
2015 Ma KH, Hung HA, Srinivasan R, Xie H, Orkin SH, Svaren J. Regulation of Peripheral Nerve Myelin Maintenance by Gene Repression through Polycomb Repressive Complex 2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 8640-52. PMID 26041929 DOI: 10.1523/JNEUROSCI.2257-14.2015  0.44
2015 Canver MC, Bauer DE, Orkin SH. Embryonic stem cells as sources of donor-independent platelets. The Journal of Clinical Investigation. 125: 2261-3. PMID 25961451 DOI: 10.1172/JCI82348  1
2015 Basak A, Hancarova M, Ulirsch JC, Balci TB, Trkova M, Pelisek M, Vlckova M, Muzikova K, Cermak J, Trka J, Dyment DA, Orkin SH, Daly MJ, Sedlacek Z, Sankaran VG. BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations. The Journal of Clinical Investigation. 125: 2363-8. PMID 25938782 DOI: 10.1172/JCI81163  0.68
2015 Yin Y, Yan P, Lu J, Song G, Zhu Y, Li Z, Zhao Y, Shen B, Huang X, Zhu H, Orkin SH, Shen X. Opposing Roles for the lncRNA Haunt and Its Genomic Locus in Regulating HOXA Gene Activation during Embryonic Stem Cell Differentiation. Cell Stem Cell. 16: 504-16. PMID 25891907 DOI: 10.1016/j.stem.2015.03.007  0.56
2015 Chung J, Bauer DE, Ghamari A, Nizzi CP, Deck KM, Kingsley PD, Yien YY, Huston NC, Chen C, Schultz IJ, Dalton AJ, Wittig JG, Palis J, Orkin SH, Lodish HF, et al. The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability. Science Signaling. 8: ra34. PMID 25872869 DOI: 10.1126/scisignal.aaa5903  1
2015 Kim PG, Nakano H, Das PP, Chen MJ, Rowe RG, Chou SS, Ross SJ, Sakamoto KM, Zon LI, Schlaeger TM, Orkin SH, Nakano A, Daley GQ. Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence. The Journal of Experimental Medicine. 212: 633-48. PMID 25870201 DOI: 10.1084/jem.20141514  1
2015 Orkin SH. 2014 William Allan Award: A hematologist's pursuit of hemoglobin genetics. American Journal of Human Genetics. 96: 354-60. PMID 25748351 DOI: 10.1016/j.ajhg.2014.12.007  1
2015 Lin MI, Price EN, Boatman S, Hagedorn EJ, Trompouki E, Satishchandran S, Carspecken CW, Uong A, DiBiase A, Yang S, Canver MC, Dahlberg A, Lu Z, Zhang CC, Orkin SH, et al. Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling. Elife. 4. PMID 25714926 DOI: 10.7554/eLife.05544  1
2015 Maier VK, Feeney CM, Taylor JE, Creech AL, Qiao JW, Szanto A, Das PP, Chevrier N, Cifuentes-Rojas C, Orkin SH, Carr SA, Jaffe JD, Mertins P, Lee JT. Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator. Molecular & Cellular Proteomics : McP. 14: 1435-46. PMID 25680957 DOI: 10.1074/mcp.M114.044586  1
2015 Xu J, Shao Z, Li D, Xie H, Kim W, Huang J, Taylor JE, Pinello L, Glass K, Jaffe JD, Yuan GC, Orkin SH. Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions. Molecular Cell. 57: 304-16. PMID 25578878 DOI: 10.1016/j.molcel.2014.12.009  1
2015 Org T, Duan D, Ferrari R, Montel-Hagen A, Van Handel B, Kerényi MA, Sasidharan R, Rubbi L, Fujiwara Y, Pellegrini M, Orkin SH, Kurdistani SK, Mikkola HK. Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence. The Embo Journal. 34: 759-77. PMID 25564442 DOI: 10.15252/embj.201490542  1
2015 Bauer DE, Canver MC, Orkin SH. Generation of genomic deletions in mammalian cell lines via CRISPR/Cas9. Journal of Visualized Experiments : Jove. PMID 25549070 DOI: 10.3791/52118  0.4
2014 Saadatpour A, Guo G, Orkin SH, Yuan GC. Characterizing heterogeneity in leukemic cells using single-cell gene expression analysis. Genome Biology. 15: 525. PMID 25517911 DOI: 10.1186/s13059-014-0525-9  1
2014 Perry JA, Kiezun A, Tonzi P, Van Allen EM, Carter SL, Baca SC, Cowley GS, Bhatt AS, Rheinbay E, Pedamallu CS, Helman E, Taylor-Weiner A, McKenna A, DeLuca DS, Lawrence MS, ... ... Orkin SH, et al. Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma. Proceedings of the National Academy of Sciences of the United States of America. 111: E5564-73. PMID 25512523 DOI: 10.1073/pnas.1419260111  1
2014 Vierstra J, Rynes E, Sandstrom R, Zhang M, Canfield T, Hansen RS, Stehling-Sun S, Sabo PJ, Byron R, Humbert R, Thurman RE, Johnson AK, Vong S, Lee K, Bates D, ... ... Orkin SH, et al. Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution. Science (New York, N.Y.). 346: 1007-12. PMID 25411453 DOI: 10.1126/science.1246426  1
2014 Li Y, Esain V, Teng L, Xu J, Kwan W, Frost IM, Yzaguirre AD, Cai X, Cortes M, Maijenburg MW, Tober J, Dzierzak E, Orkin SH, Tan K, North TE, et al. Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production. Genes & Development. 28: 2597-612. PMID 25395663 DOI: 10.1101/gad.253302.114  1
2014 Lundberg P, Takizawa H, Kubovcakova L, Guo G, Hao-Shen H, Dirnhofer S, Orkin SH, Manz MG, Skoda RC. Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F. The Journal of Experimental Medicine. 211: 2213-30. PMID 25288396 DOI: 10.1084/jem.20131371  1
2014 Yien YY, Robledo RF, Schultz IJ, Takahashi-Makise N, Gwynn B, Bauer DE, Dass A, Yi G, Li L, Hildick-Smith GJ, Cooney JD, Pierce EL, Mohler K, Dailey TA, Miyata N, ... ... Orkin SH, et al. TMEM14C is required for erythroid mitochondrial heme metabolism. The Journal of Clinical Investigation. 124: 4294-304. PMID 25157825 DOI: 10.1172/JCI76979  1
2014 Canver MC, Bauer DE, Dass A, Yien YY, Chung J, Masuda T, Maeda T, Paw BH, Orkin SH. Characterization of genomic deletion efficiency mediated by clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells. The Journal of Biological Chemistry. 289: 21312-24. PMID 24907273 DOI: 10.1074/jbc.M114.564625  1
2014 Riddell J, Gazit R, Garrison BS, Guo G, Saadatpour A, Mandal PK, Ebina W, Volchkov P, Yuan GC, Orkin SH, Rossi DJ. Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors. Cell. 157: 549-64. PMID 24766805 DOI: 10.1016/j.cell.2014.04.006  1
2014 Foudi A, Kramer DJ, Qin J, Ye D, Behlich AS, Mordecai S, Preffer FI, Amzallag A, Ramaswamy S, Hochedlinger K, Orkin SH, Hock H. Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation. The Journal of Experimental Medicine. 211: 909-27. PMID 24711581 DOI: 10.1084/jem.20131065  1
2014 Yao H, Goldman DC, Nechiporuk T, Kawane S, McWeeney SK, Tyner JW, Fan G, Kerenyi MA, Orkin SH, Fleming WH, Mandel G. Corepressor Rcor1 is essential for murine erythropoiesis. Blood. 123: 3175-84. PMID 24652990 DOI: 10.1182/blood-2013-11-538678  1
2014 Pinello L, Xu J, Orkin SH, Yuan GC. Analysis of chromatin-state plasticity identifies cell-type-specific regulators of H3K27me3 patterns. Proceedings of the National Academy of Sciences of the United States of America. 111: E344-53. PMID 24395799 DOI: 10.1073/pnas.1322570111  1
2014 Das PP, Shao Z, Beyaz S, Apostolou E, Pinello L, De Los Angeles A, O'Brien K, Atsma JM, Fujiwara Y, Nguyen M, Ljuboja D, Guo G, Woo A, Yuan GC, Onder T, ... ... Orkin SH, et al. Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity. Molecular Cell. 53: 32-48. PMID 24361252 DOI: 10.1016/j.molcel.2013.11.011  1
2014 Xie H, Xu J, Hsu JH, Nguyen M, Fujiwara Y, Peng C, Orkin SH. Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner. Cell Stem Cell. 14: 68-80. PMID 24239285 DOI: 10.1016/j.stem.2013.10.001  1
2013 Elagib KE, Rubinstein JD, Delehanty LL, Ngoh VS, Greer PA, Li S, Lee JK, Li Z, Orkin SH, Mihaylov IS, Goldfarb AN. Calpain 2 activation of P-TEFb drives megakaryocyte morphogenesis and is disrupted by leukemogenic GATA1 mutation. Developmental Cell. 27: 607-20. PMID 24369834 DOI: 10.1016/j.devcel.2013.11.013  1
2013 Bauer DE, Kamran SC, Lessard S, Xu J, Fujiwara Y, Lin C, Shao Z, Canver MC, Smith EC, Pinello L, Sabo PJ, Vierstra J, Voit RA, Yuan GC, Porteus MH, ... ... Orkin SH, et al. An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. Science (New York, N.Y.). 342: 253-7. PMID 24115442 DOI: 10.1126/science.1242088  1
2013 Guo G, Luc S, Marco E, Lin TW, Peng C, Kerenyi MA, Beyaz S, Kim W, Xu J, Das PP, Neff T, Zou K, Yuan GC, Orkin SH. Mapping cellular hierarchy by single-cell analysis of the cell surface repertoire. Cell Stem Cell. 13: 492-505. PMID 24035353 DOI: 10.1016/j.stem.2013.07.017  1
2013 Kim W, Bird GH, Neff T, Guo G, Kerenyi MA, Walensky LD, Orkin SH. Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nature Chemical Biology. 9: 643-50. PMID 23974116 DOI: 10.1038/nchembio.1331  1
2013 Luc S, Orkin SH. Delineating the mixed lineage leukemia gene expression network in hematopoietic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 11670-1. PMID 23824294 DOI: 10.1073/pnas.1310349110  1
2013 Kerenyi MA, Shao Z, Hsu YJ, Guo G, Luc S, O'Brien K, Fujiwara Y, Peng C, Nguyen M, Orkin SH. Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation. Elife. 2: e00633. PMID 23795291 DOI: 10.7554/eLife.00633  1
2013 Xu J, Bauer DE, Kerenyi MA, Vo TD, Hou S, Hsu YJ, Yao H, Trowbridge JJ, Mandel G, Orkin SH. Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A. Proceedings of the National Academy of Sciences of the United States of America. 110: 6518-23. PMID 23576758 DOI: 10.1073/pnas.1303976110  1
2013 Baena E, Shao Z, Linn DE, Glass K, Hamblen MJ, Fujiwara Y, Kim J, Nguyen M, Zhang X, Godinho FJ, Bronson RT, Mucci LA, Loda M, Yuan GC, Orkin SH, et al. ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients. Genes & Development. 27: 683-98. PMID 23512661 DOI: 10.1101/gad.211011.112  1
2013 Sankaran VG, Orkin SH. Genome-wide association studies of hematologic phenotypes: A window into human hematopoiesis Current Opinion in Genetics and Development. 23: 339-344. PMID 23477921 DOI: 10.1016/j.gde.2013.02.006  1
2013 Staber PB, Zhang P, Ye M, Welner RS, Nombela-Arrieta C, Bach C, Kerenyi M, Bartholdy BA, Zhang H, Alberich-Jordà M, Lee S, Yang H, Ng F, Zhang J, Leddin M, ... ... Orkin SH, et al. Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells. Molecular Cell. 49: 934-46. PMID 23395001 DOI: 10.1016/j.molcel.2013.01.007  0.32
2013 Sankaran VG, Orkin SH. The switch from fetal to adult hemoglobin Cold Spring Harbor Perspectives in Medicine. 3. PMID 23209159 DOI: 10.1101/cshperspect.a011643  1
2013 Bai X, Trowbridge JJ, Riley E, Lee JA, DiBiase A, Kaartinen VM, Orkin SH, Zon LI. TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes. Developmental Biology. 373: 422-30. PMID 23159334 DOI: 10.1016/j.ydbio.2012.10.008  1
2012 Maclean GA, Menne TF, Guo G, Sanchez DJ, Park IH, Daley GQ, Orkin SH. Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 17567-72. PMID 23045682 DOI: 10.1073/pnas.1215468109  1
2012 Xu J, Shao Z, Glass K, Bauer DE, Pinello L, Van Handel B, Hou S, Stamatoyannopoulos JA, Mikkola HK, Yuan GC, Orkin SH. Combinatorial assembly of developmental stage-specific enhancers controls gene expression programs during human erythropoiesis. Developmental Cell. 23: 796-811. PMID 23041383 DOI: 10.1016/j.devcel.2012.09.003  1
2012 Sankaran VG, Ludwig LS, Sicinska E, Xu J, Bauer DE, Eng JC, Patterson HC, Metcalf RA, Natkunam Y, Orkin SH, Sicinski P, Lander ES, Lodish HF. Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number. Genes & Development. 26: 2075-87. PMID 22929040 DOI: 10.1101/gad.197020.112  1
2012 Bauer DE, Kamran SC, Orkin SH. Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders. Blood. 120: 2945-53. PMID 22904296 DOI: 10.1182/blood-2012-06-292078  1
2012 Van Handel B, Montel-Hagen A, Sasidharan R, Nakano H, Ferrari R, Boogerd CJ, Schredelseker J, Wang Y, Hunter S, Org T, Zhou J, Li X, Pellegrini M, Chen JN, Orkin SH, et al. Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell. 150: 590-605. PMID 22863011 DOI: 10.1016/j.cell.2012.06.026  1
2012 Funnell AP, Norton LJ, Mak KS, Burdach J, Artuz CM, Twine NA, Wilkins MR, Power CA, Hung TT, Perdomo J, Koh P, Bell-Anderson KS, Orkin SH, Fraser ST, Perkins AC, et al. The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo. Molecular and Cellular Biology. 32: 3281-92. PMID 22711990 DOI: 10.1128/MCB.00173-12  1
2012 Sankaran VG, Ghazvinian R, Do R, Thiru P, Vergilio JA, Beggs AH, Sieff CA, Orkin SH, Nathan DG, Lander ES, Gazda HT. Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia. The Journal of Clinical Investigation. 122: 2439-43. PMID 22706301 DOI: 10.1172/JCI63597  1
2012 Shao Z, Zhang Y, Yuan GC, Orkin SH, Waxman DJ. MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets. Genome Biology. 13: R16. PMID 22424423 DOI: 10.1186/gb-2012-13-3-r16  1
2012 Neff T, Sinha AU, Kluk MJ, Zhu N, Khattab MH, Stein L, Xie H, Orkin SH, Armstrong SA. Polycomb repressive complex 2 is required for MLL-AF9 leukemia. Proceedings of the National Academy of Sciences of the United States of America. 109: 5028-33. PMID 22396593 DOI: 10.1073/pnas.1202258109  1
2012 Parikh VN, Jin RC, Rabello S, Gulbahce N, White K, Hale A, Cottrill KA, Shaik RS, Waxman AB, Zhang YY, Maron BA, Hartner JC, Fujiwara Y, Orkin SH, Haley KJ, et al. MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach. Circulation. 125: 1520-32. PMID 22371328 DOI: 10.1161/CIRCULATIONAHA.111.060269  1
2012 Trowbridge JJ, Sinha AU, Zhu N, Li M, Armstrong SA, Orkin SH. Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. Genes & Development. 26: 344-9. PMID 22345515 DOI: 10.1101/gad.184341.111  1
2012 Chau BN, Xin C, Hartner J, Ren S, Castano AP, Linn G, Li J, Tran PT, Kaimal V, Huang X, Chang AN, Li S, Kalra A, Grafals M, Portilla D, ... ... Orkin SH, et al. MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways. Science Translational Medicine. 4: 121ra18. PMID 22344686 DOI: 10.1126/scitranslmed.3003205  1
2012 Shi Y, Kirwan P, Smith J, MacLean G, Orkin SH, Livesey FJ. A human stem cell model of early Alzheimer's disease pathology in Down syndrome. Science Translational Medicine. 4: 124ra29. PMID 22344463 DOI: 10.1126/scitranslmed.3003771  1
2012 He A, Shen X, Ma Q, Cao J, von Gise A, Zhou P, Wang G, Marquez VE, Orkin SH, Pu WT. PRC2 directly methylates GATA4 and represses its transcriptional activity. Genes & Development. 26: 37-42. PMID 22215809 DOI: 10.1101/gad.173930.111  0.52
2012 Trowbridge JJ, Orkin SH. Dnmt3a silences hematopoietic stem cell self-renewal. Nature Genetics. 44: 13-4. PMID 22200773 DOI: 10.1038/ng.1043  1
2012 He A, Ma Q, Cao J, von Gise A, Zhou P, Xie H, Zhang B, Hsing M, Christodoulou DC, Cahan P, Daley GQ, Kong SW, Orkin SH, Seidman CE, Seidman JG, et al. Polycomb repressive complex 2 regulates normal development of the mouse heart. Circulation Research. 110: 406-15. PMID 22158708 DOI: 10.1161/CIRCRESAHA.111.252205  1
2011 Kim J, Orkin SH. Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine. Genome Medicine. 3: 75. PMID 22126538 DOI: 10.1186/gm291  1
2011 Xu J, Peng C, Sankaran VG, Shao Z, Esrick EB, Chong BG, Ippolito GC, Fujiwara Y, Ebert BL, Tucker PW, Orkin SH. Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. Science (New York, N.Y.). 334: 993-6. PMID 21998251 DOI: 10.1126/science.1211053  1
2011 Fidalgo M, Shekar PC, Ang YS, Fujiwara Y, Orkin SH, Wang J. Zfp281 functions as a transcriptional repressor for pluripotency of mouse embryonic stem cells. Stem Cells (Dayton, Ohio). 29: 1705-16. PMID 21915945 DOI: 10.1002/stem.736  1
2011 Sankaran VG, Xu J, Byron R, Greisman HA, Fisher C, Weatherall DJ, Sabath DE, Groudine M, Orkin SH, Premawardhena A, Bender MA. A functional element necessary for fetal hemoglobin silencing. The New England Journal of Medicine. 365: 807-14. PMID 21879898 DOI: 10.1056/NEJMoa1103070  1
2011 Lu TX, Hartner J, Lim EJ, Fabry V, Mingler MK, Cole ET, Orkin SH, Aronow BJ, Rothenberg ME. MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity. Journal of Immunology (Baltimore, Md. : 1950). 187: 3362-73. PMID 21849676 DOI: 10.4049/jimmunol.1101235  1
2011 Lin W, Cao J, Liu J, Beshiri ML, Fujiwara Y, Francis J, Cherniack AD, Geisen C, Blair LP, Zou MR, Shen X, Kawamori D, Liu Z, Grisanzio C, Watanabe H, ... ... Orkin SH, et al. Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proceedings of the National Academy of Sciences of the United States of America. 108: 13379-86. PMID 21788502 DOI: 10.1073/pnas.1110104108  1
2011 Orkin SH, Hochedlinger K. Chromatin connections to pluripotency and cellular reprogramming. Cell. 145: 835-50. PMID 21663790 DOI: 10.1016/j.cell.2011.05.019  1
2011 Orkin SH. Genome Medicine: stem cells, genomics and translational research. Genome Medicine. 3: 34. PMID 21658298 DOI: 10.1186/gm250  1
2011 Xu J, Orkin SH. The erythroid/myeloid lineage fate paradigm takes a new player. The Embo Journal. 30: 983-5. PMID 21407249 DOI: 10.1038/emboj.2011.45  1
2011 Snow JW, Trowbridge JJ, Johnson KD, Fujiwara T, Emambokus NE, Grass JA, Orkin SH, Bresnick EH. Context-dependent function of "GATA switch" sites in vivo. Blood. 117: 4769-72. PMID 21398579 DOI: 10.1182/blood-2010-10-313031  1
2011 Koh KP, Yabuuchi A, Rao S, Huang Y, Cunniff K, Nardone J, Laiho A, Tahiliani M, Sommer CA, Mostoslavsky G, Lahesmaa R, Orkin SH, Rodig SJ, Daley GQ, Rao A. Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell. 8: 200-13. PMID 21295276 DOI: 10.1016/j.stem.2011.01.008  1
2011 Sankaran VG, Menne TF, Šćepanović D, Vergilio JA, Ji P, Kim J, Thiru P, Orkin SH, Lander ES, Lodish HF. MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. Proceedings of the National Academy of Sciences of the United States of America. 108: 1519-24. PMID 21205891 DOI: 10.1073/pnas.1018384108  1
2011 Bauer DE, Orkin SH. Update on fetal hemoglobin gene regulation in hemoglobinopathies. Current Opinion in Pediatrics. 23: 1-8. PMID 21157349 DOI: 10.1097/MOP.0b013e3283420fd0  1
2011 Wilber A, Hargrove PW, Kim YS, Riberdy JM, Sankaran VG, Papanikolaou E, Georgomanoli M, Anagnou NP, Orkin SH, Nienhuis AW, Persons DA. Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer. Blood. 117: 2817-26. PMID 21156846 DOI: 10.1182/blood-2010-08-300723  1
2010 Kerenyi MA, Orkin SH. Networking erythropoiesis. The Journal of Experimental Medicine. 207: 2537-41. PMID 21098097 DOI: 10.1084/jem.20102260  1
2010 Galarneau G, Palmer CD, Sankaran VG, Orkin SH, Hirschhorn JN, Lettre G. Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation Nature Genetics. 42: 1049-1051. PMID 21057501 DOI: 10.1038/ng.707  1
2010 Sankaran VG, Lettre G, Orkin SH, Hirschhorn JN. Modifier genes in Mendelian disorders: the example of hemoglobin disorders. Annals of the New York Academy of Sciences. 1214: 47-56. PMID 21039591 DOI: 10.1111/j.1749-6632.2010.05821.x  1
2010 Wilson BG, Wang X, Shen X, McKenna ES, Lemieux ME, Cho YJ, Koellhoffer EC, Pomeroy SL, Orkin SH, Roberts CW. Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation. Cancer Cell. 18: 316-28. PMID 20951942 DOI: 10.1016/j.ccr.2010.09.006  1
2010 Kim J, Woo AJ, Chu J, Snow JW, Fujiwara Y, Kim CG, Cantor AB, Orkin SH. A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell. 143: 313-24. PMID 20946988 DOI: 10.1016/j.cell.2010.09.010  1
2010 Snow JW, Trowbridge JJ, Fujiwara T, Emambokus NE, Grass JA, Orkin SH, Bresnick EH. A single cis element maintains repression of the key developmental regulator Gata2. Plos Genetics. 6: e1001103. PMID 20838598 DOI: 10.1371/journal.pgen.1001103  1
2010 Rao S, Zhen S, Roumiantsev S, McDonald LT, Yuan GC, Orkin SH. Differential roles of Sall4 isoforms in embryonic stem cell pluripotency. Molecular and Cellular Biology. 30: 5364-80. PMID 20837710 DOI: 10.1128/MCB.00419-10  0.52
2010 Sankaran VG, Xu J, Orkin SH. Transcriptional silencing of fetal hemoglobin by BCL11A. Annals of the New York Academy of Sciences. 1202: 64-8. PMID 20712774 DOI: 10.1111/j.1749-6632.2010.05574.x  1
2010 Klusmann JH, Godinho FJ, Heitmann K, Maroz A, Koch ML, Reinhardt D, Orkin SH, Li Z. Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis. Genes & Development. 24: 1659-72. PMID 20679399 DOI: 10.1101/gad.1903410  0.56
2010 Orkin SH, Higgs DR. Medicine. Sickle cell disease at 100 years. Science (New York, N.Y.). 329: 291-2. PMID 20647458 DOI: 10.1126/science.1194035  1
2010 Bai X, Kim J, Yang Z, Jurynec MJ, Akie TE, Lee J, LeBlanc J, Sessa A, Jiang H, DiBiase A, Zhou Y, Grunwald DJ, Lin S, Cantor AB, Orkin SH, et al. TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell. 142: 133-43. PMID 20603019 DOI: 10.1016/j.cell.2010.05.028  1
2010 Snow JW, Kim J, Currie CR, Xu J, Orkin SH. Sumoylation regulates interaction of FOG1 with C-terminal-binding protein (CTBP). The Journal of Biological Chemistry. 285: 28064-75. PMID 20587419 DOI: 10.1074/jbc.M109.096909  1
2010 Xu J, Sankaran VG, Ni M, Menne TF, Puram RV, Kim W, Orkin SH. Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6. Genes & Development. 24: 783-98. PMID 20395365 DOI: 10.1101/gad.1897310  1
2010 Trowbridge JJ, Orkin SH. DNA methylation in adult stem cells: new insights into self-renewal. Epigenetics : Official Journal of the Dna Methylation Society. 5: 189-93. PMID 20364115 DOI: 10.4161/epi.5.3.11374  1
2010 Sankaran VG, Xu J, Orkin SH. Advances in the understanding of haemoglobin switching. British Journal of Haematology. 149: 181-94. PMID 20201948 DOI: 10.1111/j.1365-2141.2010.08105.x  1
2010 Klusmann JH, Li Z, Böhmer K, Maroz A, Koch ML, Emmrich S, Godinho FJ, Orkin SH, Reinhardt D. miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. Genes & Development. 24: 478-90. PMID 20194440 DOI: 10.1101/gad.1856210  0.56
2010 Nathan DG, Orkin SH. Musings on genome medicine: Hepatitis C. Genome Medicine. 2: 4. PMID 20193049 DOI: 10.1186/gm125  1
2010 Alford KA, Slender A, Vanes L, Li Z, Fisher EM, Nizetic D, Orkin SH, Roberts I, Tybulewicz VL. Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome. Blood. 115: 2928-37. PMID 20154221 DOI: 10.1182/blood-2009-06-227629  0.56
2010 Kim J, Orkin SH. Systematic tracking of cell fate changes. Nature Biotechnology. 28: 146-7. PMID 20139953 DOI: 10.1038/nbt0210-146  1
2009 Shen X, Kim W, Fujiwara Y, Simon MD, Liu Y, Mysliwiec MR, Yuan GC, Lee Y, Orkin SH. Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell. 139: 1303-14. PMID 20064376 DOI: 10.1016/j.cell.2009.12.003  1
2009 Nathan DG, Orkin SH. Musings on genome medicine: enzyme-replacement therapy of the lysosomal storage diseases. Genome Medicine. 1: 114. PMID 20017892 DOI: 10.1186/gm114  1
2009 Nathan DG, Orkin SH. Musings on genome medicine: Crohn's disease. Genome Medicine. 1: 103. PMID 19891793 DOI: 10.1186/gm103  1
2009 Nathan DG, Orkin SH. Musings on genome medicine: the slow but inexorable process of medical care reform in the United States. Genome Medicine. 1: 94. PMID 19822025 DOI: 10.1186/gm94  1
2009 Trowbridge JJ, Snow JW, Kim J, Orkin SH. DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells. Cell Stem Cell. 5: 442-9. PMID 19796624 DOI: 10.1016/j.stem.2009.08.016  1
2009 Nathan DG, Orkin SH. Musings on genome medicine: the Obama effect redux. Genome Medicine. 1: 86. PMID 19769781 DOI: 10.1186/gm86  1
2009 Sankaran VG, Xu J, Ragoczy T, Ippolito GC, Walkley CR, Maika SD, Fujiwara Y, Ito M, Groudine M, Bender MA, Tucker PW, Orkin SH. Developmental and species-divergent globin switching are driven by BCL11A. Nature. 460: 1093-7. PMID 19657335 DOI: 10.1038/nature08243  1
2009 Snow JW, Orkin SH. Translational isoforms of FOG1 regulate GATA1-interacting complexes. The Journal of Biological Chemistry. 284: 29310-9. PMID 19654328 DOI: 10.1074/jbc.M109.043497  1
2009 Nathan DG, Orkin SH. Musings on genome medicine: cholesterol and coronary artery disease. Genome Medicine. 1: 60. PMID 19519958 DOI: 10.1186/gm60  1
2009 Nathan DG, Orkin SH. Musings on genome medicine: cancer genetics and the promise of effective treatment. Genome Medicine. 1: 49. PMID 19439059 DOI: 10.1186/gm49  1
2009 Nathan DG, Orkin SH. Musings on genome medicine: gene therapy. Genome Medicine. 1: 38. PMID 19435468 DOI: 10.1186/gm38  1
2009 Nathan DG, Orkin SH. Musings on genome medicine: genome wide association studies. Genome Medicine. 1: 3. PMID 19348690 DOI: 10.1186/gm3  1
2009 Nathan DG, Orkin SH. Musings on genome medicine: the Obama effect. Genome Medicine. 1: 30. PMID 19341501 DOI: 10.1186/gm30  1
2009 Nathan DG, Orkin SH. Musings on genome medicine: abuse of genetic tests. Genome Medicine. 1: 18. PMID 19341489 DOI: 10.1186/gm18  1
2009 Hu G, Kim J, Xu Q, Leng Y, Orkin SH, Elledge SJ. A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal Genes and Development. 23: 837-848. PMID 19339689 DOI: 10.1101/gad.1769609  1
2009 Kim J, Cantor AB, Orkin SH, Wang J. Use of in vivo biotinylation to study protein-protein and protein-DNA interactions in mouse embryonic stem cells. Nature Protocols. 4: 506-17. PMID 19325547 DOI: 10.1038/nprot.2009.23  1
2009 Wang J, Cantor AB, Orkin SH. Tandem affinity purification of protein complexes in mouse embryonic stem cells using in vivo biotinylation. Current Protocols in Stem Cell Biology. Unit1B.5. PMID 19306258 DOI: 10.1002/9780470151808.sc01b05s8  1
2009 Shen X, Orkin SH. Glimpses of the epigenetic landscape. Cell Stem Cell. 4: 1-2. PMID 19128786 DOI: 10.1016/j.stem.2008.12.006  1
2009 Fujiwara Y, Orkin SH. Molecular regulation of the state of embryonic stem cells Stem Cells and Cancer. 33-60. DOI: 10.1007/978-0-387-89611-3_2  1
2008 Sankaran VG, Menne TF, Xu J, Akie TE, Lettre G, Van Handel B, Mikkola HK, Hirschhorn JN, Cantor AB, Orkin SH. Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science (New York, N.Y.). 322: 1839-42. PMID 19056937 DOI: 10.1126/science.1165409  1
2008 Shen X, Liu Y, Hsu YJ, Fujiwara Y, Kim J, Mao X, Yuan GC, Orkin SH. EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Molecular Cell. 32: 491-502. PMID 19026780 DOI: 10.1016/j.molcel.2008.10.016  1
2008 Walkley CR, Sankaran VG, Orkin SH. Rb and hematopoiesis: stem cells to anemia. Cell Division. 3: 13. PMID 18775080 DOI: 10.1186/1747-1028-3-13  1
2008 Lettre G, Sankaran VG, Bezerra MA, Araújo AS, Uda M, Sanna S, Cao A, Schlessinger D, Costa FF, Hirschhorn JN, Orkin SH. DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Proceedings of the National Academy of Sciences of the United States of America. 105: 11869-74. PMID 18667698 DOI: 10.1073/pnas.0804799105  1
2008 Walkley CR, Qudsi R, Sankaran VG, Perry JA, Gostissa M, Roth SI, Rodda SJ, Snay E, Dunning P, Fahey FH, Alt FW, McMahon AP, Orkin SH. Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes & Development. 22: 1662-76. PMID 18559481 DOI: 10.1101/gad.1656808  1
2008 Wang J, Levasseur DN, Orkin SH. Requirement of Nanog dimerization for stem cell self-renewal and pluripotency. Proceedings of the National Academy of Sciences of the United States of America. 105: 6326-31. PMID 18436640 DOI: 10.1073/pnas.0802288105  1
2008 Kim J, Chu J, Shen X, Wang J, Orkin SH. An extended transcriptional network for pluripotency of embryonic stem cells. Cell. 132: 1049-61. PMID 18358816 DOI: 10.1016/j.cell.2008.02.039  1
2008 Orkin SH, Zon LI. SnapShot: Hematopoiesis Cell. 132. PMID 18295585 DOI: 10.1016/j.cell.2008.02.013  1
2008 Orkin SH, Zon LI. Hematopoiesis: An Evolving Paradigm for Stem Cell Biology Cell. 132: 631-644. PMID 18295580 DOI: 10.1016/j.cell.2008.01.025  1
2008 Sankaran VG, Orkin SH, Walkley CR. Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis. Genes & Development. 22: 463-75. PMID 18258751 DOI: 10.1101/gad.1627208  1
2008 Uda M, Galanello R, Sanna S, Lettre G, Sankaran VG, Chen W, Usala G, Busonero F, Maschio A, Albai G, Piras MG, Sestu N, Lai S, Dei M, Mulas A, ... ... Orkin SH, et al. Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. Proceedings of the National Academy of Sciences of the United States of America. 105: 1620-5. PMID 18245381 DOI: 10.1073/pnas.0711566105  1
2008 Wang J, Orkin SH. A protein roadmap to pluripotency and faithful reprogramming Cells Tissues Organs. 188: 23-30. PMID 18196921 DOI: 10.1159/000113532  1
2008 Wang J, Levasseur DN, Orkin SH. Requirement of Nanog dimerization for stem cell self-renewal and pluripotency (Proceedings of the National Academy of Sciences of the United States of America (2008) 105:17 (6326-6331) DOI: 10.1073/pnas.0802288105) Proceedings of the National Academy of Sciences of the United States of America. 105: 8801-8802. DOI: 10.1073/pnas.0804442105  1
2007 Orkin SH, Pera M. Stem cells down under-ISSCR 2007 Cell Stem Cell. 1: 271-276. PMID 18399027 DOI: 10.1016/j.stem.2007.08.007  1
2007 Wang J, Theunissen TW, Orkin SH. Site-directed, virus-free, and inducible RNAi in embryonic stem cells Proceedings of the National Academy of Sciences of the United States of America. 104: 20850-20855. PMID 18093939 DOI: 10.1073/pnas.0710565105  1
2007 Xie H, Orkin SH. Immunology: Changed destiny Nature. 449: 410-411. PMID 17898754 DOI: 10.1038/449410a  1
2007 Saleque S, Kim J, Rooke HM, Orkin SH. Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Molecular Cell. 27: 562-72. PMID 17707228 DOI: 10.1016/j.molcel.2007.06.039  1
2007 North TE, Goessling W, Walkley CR, Lengerke C, Kopani KR, Lord AM, Weber GJ, Bowman TV, Jang IH, Grosser T, Fitzgerald GA, Daley GQ, Orkin SH, Zon LI. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 447: 1007-11. PMID 17581586 DOI: 10.1038/nature05883  1
2006 Mikkola HK, Orkin SH. The journey of developing hematopoietic stem cells. Development (Cambridge, England). 133: 3733-44. PMID 16968814 DOI: 10.1242/dev.02568  1
2006 Rao S, Orkin SH. Unraveling the transcriptional network controlling ES cell pluripotency Genome Biology. 7. PMID 16942632 DOI: 10.1186/gb-2006-7-8-230  1
2006 Walkley CR, Orkin SH. Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cells Proceedings of the National Academy of Sciences of the United States of America. 103: 9057-9062. PMID 16754850 DOI: 10.1073/pnas.0603389103  1
2006 Orkin SH. Reactions to the Hwang scandal [2] Science. 311: 606-607. PMID 16459362  1
2006 Rooke HM, Orkin SH. Phosphorylation of Gata1 at serine residues 72, 142, and 310 is not essential for hematopoiesis in vivo Blood. 107: 3527-3530. PMID 16391009 DOI: 10.1182/blood-2005-10-4309  1
2006 Hock H, Orkin SH. Zinc-finger transcription factor Gfi-1: versatile regulator of lymphocytes, neutrophils and hematopoietic stem cells. Current Opinion in Hematology. 13: 1-6. PMID 16319680  1
2005 Orkin SH. Chipping away at the embryonic stem cell network Cell. 122: 828-830. PMID 16179251 DOI: 10.1016/j.cell.2005.09.002  1
2005 Tsai J, Tong Q, Tan G, Chang AN, Orkin SH, Hotamisligil GS. The transcription factor GATA2 regulates differentiation of brown adipocytes. Embo Reports. 6: 879-84. PMID 16082385 DOI: 10.1038/sj.embor.7400490  1
2005 Hock H, Orkin SH. Stem cells: the road not taken. Nature. 435: 573-5. PMID 15931202 DOI: 10.1038/435573a  1
2005 Li Z, Godinho FJ, Klusmann JH, Garriga-Canut M, Yu C, Orkin SH. Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nature Genetics. 37: 613-9. PMID 15895080 DOI: 10.1038/ng1566  0.56
2005 Cantor AB, Orkin SH. Coregulation of GATA factors by the Friend of GATA (FOG) family of multitype zinc finger proteins. Seminars in Cell & Developmental Biology. 16: 117-28. PMID 15659346 DOI: 10.1016/j.semcdb.2004.10.006  1
2005 Mikkola HK, Orkin SH. Gene targeting and transgenic strategies for the analysis of hematopoietic development in the mouse. Methods in Molecular Medicine. 105: 3-22. PMID 15492385  1
2004 Humbles AA, Lloyd CM, McMillan SJ, Friend DS, Xanthou G, McKenna EE, Ghiran S, Gerard NP, Yu C, Orkin SH, Gerard C. A critical role for eosinophils in allergic airways remodeling. Science (New York, N.Y.). 305: 1776-9. PMID 15375268 DOI: 10.1126/science.1100283  1
2004 Ransom DG, Bahary N, Niss K, Traver D, Burns C, Trede NS, Paffett-Lugassy N, Saganic WJ, Lim CA, Hersey C, Zhou Y, Barut BA, Lin S, Kingsley PD, Palis J, ... Orkin SH, et al. The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis. Plos Biology. 2: E237. PMID 15314655 DOI: 10.1371/journal.pbio.0020237  1
2004 Garriga-Canut M, Orkin SH. Transforming acidic coiled-coil protein 3 (TACC3) controls friend of GATA-1 (FOG-1) subcellular localization and regulates the association between GATA-1 and FOG-1 during hematopoiesis Journal of Biological Chemistry. 279: 23597-23605. PMID 15037632 DOI: 10.1074/jbc.M313987200  1
2004 Roberts CW, Orkin SH. The SWI/SNF complex--chromatin and cancer. Nature Reviews. Cancer. 4: 133-42. PMID 14964309 DOI: 10.1038/nrc1273  1
2004 Fujiwara Y, Chang AN, Williams AM, Orkin SH. Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development. Blood. 103: 583-5. PMID 14504093 DOI: 10.1182/blood-2003-08-2870  1
2003 Orkin SH. Priming the hematopoietic pump Immunity. 19: 633-634. PMID 14614848 DOI: 10.1016/S1074-7613(03)00302-9  1
2002 Yu C, Niakan KK, Matsushita M, Stamatoyannopoulos G, Orkin SH, Raskind WH. X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction. Blood. 100: 2040-5. PMID 12200364 DOI: 10.1182/blood-2002-02-0387  1
2002 Orkin SH, Morrison SJ. Stem-cell competition. Nature. 418: 25-7. PMID 12097889 DOI: 10.1038/418025a  1
2002 Chang AN, Cantor AB, Fujiwara Y, Lodish MB, Droho S, Crispino JD, Orkin SH. GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis. Proceedings of the National Academy of Sciences of the United States of America. 99: 9237-42. PMID 12077323 DOI: 10.1073/pnas.142302099  1
2002 Crispino JD, Orkin SH. The use of altered specificity mutants to probe specific protein-protein interactions involved in the activation of GATA-1 target genes. Methods (San Diego, Calif.). 26: 84-92. PMID 12054907 DOI: 10.1016/S1046-2023(02)00010-5  1
2002 Yu C, Cantor AB, Yang H, Browne C, Wells RA, Fujiwara Y, Orkin SH. Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. The Journal of Experimental Medicine. 195: 1387-95. PMID 12045237  1
2002 Cantor AB, Orkin SH. Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene. 21: 3368-76. PMID 12032775 DOI: 10.1038/sj.onc.1205326  1
2002 Cantor AB, Katz SG, Orkin SH. Distinct domains of the GATA-1 cofactor FOG-1 differentially influence erythroid versus megakaryocytic maturation. Molecular and Cellular Biology. 22: 4268-79. PMID 12024038 DOI: 10.1128/MCB.22.12.4268-4279.2002  1
2002 Katz SG, Cantor AB, Orkin SH. Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo. Molecular and Cellular Biology. 22: 3121-8. PMID 11940669 DOI: 10.1128/MCB.22.9.3121-3128.2002  1
2002 Orkin SH, Zon LI. Hematopoiesis and stem cells: Plasticity versus development heterogeneity Nature Immunology. 3: 323-328. PMID 11919568 DOI: 10.1038/ni0402-323  1
2002 Mikkola HK, Orkin SH. The search for the hemangioblast. Journal of Hematotherapy & Stem Cell Research. 11: 9-17. PMID 11847000 DOI: 10.1089/152581602753448504  1
2002 Saleque S, Cameron S, Orkin SH. The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages Genes and Development. 16: 301-306. PMID 11825872 DOI: 10.1101/gad.959102  1
2001 Han AP, Yu C, Lu L, Fujiwara Y, Browne C, Chin G, Fleming M, Leboulch P, Orkin SH, Chen JJ. Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency. The Embo Journal. 20: 6909-18. PMID 11726526 DOI: 10.1093/emboj/20.23.6909  1
2001 Cantor AB, Orkin SH. Hematopoietic development: a balancing act. Current Opinion in Genetics & Development. 11: 513-9. PMID 11532392 DOI: 10.1016/S0959-437X(00)00226-4  1
2001 Mead PE, Deconinck AE, Huber TL, Orkin SH, Zon LI. Primitive erythropoiesis in the Xenopus embryo: the synergistic role of LMO-2, SCL and GATA-binding proteins. Development (Cambridge, England). 128: 2301-8. PMID 11493549  1
2000 Orkin SH. Diversification of haematopoietic stem cells to specific lineages Nature Reviews Genetics. 1: 57-64. PMID 11262875  1
2000 Orkin SH. Stem cell alchemy Nature Medicine. 6: 1212-1213. PMID 11062526 DOI: 10.1038/81303  1
2000 Zhang P, Zhang X, Iwama A, Yu C, Smith KA, Mueller BU, Narravula S, Torbett BE, Orkin SH, Tenen DG. PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding. Blood. 96: 2641-8. PMID 11023493  0.56
2000 Shirihai OS, Gregory T, Yu C, Orkin SH, Weiss MJ. ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation. The Embo Journal. 19: 2492-502. PMID 10835348 DOI: 10.1093/emboj/19.11.2492  0.56
2000 Deconinck AE, Mead PE, Tevosian SG, Crispino JD, Katz SG, Zon LI, Orkin SH. FOG acts as a repressor of red blood cell development in Xenopus Development. 127: 2031-2040. PMID 10769228  1
1999 Orkin SH, Weiss MJ. Cutting red-cell production Nature. 401: 433-436. PMID 10519540 DOI: 10.1038/46699  1
1999 Porcher C, Liao EC, Fujiwara Y, Zon LI, Orkin SH. Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding. Development (Cambridge, England). 126: 4603-15. PMID 10498694  1
1999 Gregory T, Yu C, Ma A, Orkin SH, Blobel GA, Weiss MJ. GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-x(L) expression Blood. 94: 87-96. PMID 10381501  1
1999 Strauss EC, Orkin SH. Guanine-adenine ligation-mediated polymerase chain reaction in vivo footprinting Methods in Enzymology. 304: 572-584. PMID 10372382 DOI: 10.1016/S0076-6879(99)04033-1  1
1999 Mao X, Fujiwara Y, Orkin SH. Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice Proceedings of the National Academy of Sciences of the United States of America. 96: 5037-5042. PMID 10220414 DOI: 10.1073/pnas.96.9.5037  1
1998 Orkin SH, Shivdasani RA, Fujiwara Y, McDevitt MA. Transcription factor GATA-1 in megakaryocyte development Stem Cells (Dayton, Ohio). 16: 79-83. PMID 11012179  1
1998 Orkin SH. Embryonic stem cells and transgenic mice in the study of hematopoiesis International Journal of Developmental Biology. 42: 927-934. PMID 9853823  1
1998 Tsai FY, Browne CP, Orkin SH. Knock-in mutation of transcription factor GATA-3 into the GATA-1 locus: partial rescue of GATA-1 loss of function in erythroid cells. Developmental Biology. 196: 218-27. PMID 9576834 DOI: 10.1006/dbio.1997.8842  1
1998 Visvader JE, Fujiwara Y, Orkin SH. Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development. Genes & Development. 12: 473-9. PMID 9472016  1
1997 Orkin SH, Zon LI. Genetics of erythropoiesis: Induced mutations in mice and zebrafish Annual Review of Genetics. 31: 33-60. PMID 9442889 DOI: 10.1146/annurev.genet.31.1.33  1
1997 Tsang AP, Visvader JE, Turner CA, Fujiwara Y, Yu C, Weiss MJ, Crossley M, Orkin SH. FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. Cell. 90: 109-19. PMID 9230307 DOI: 10.1016/S0092-8674(00)80318-9  1
1997 Tsai FY, Orkin SH. Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation Blood. 89: 3636-3643. PMID 9160668  1
1997 Lien LL, Lee Y, Orkin SH. Regulation of the myeloid-cell-expressed human gp91-phox gene as studied by transfer of yeast artificial chromosome clones into embryonic stem cells: Suppression of a variegated cellular pattern of expression requires a full complement of distant cis elements Molecular and Cellular Biology. 17: 2279-2290. PMID 9121478  1
1997 Weiss MJ, Yu C, Orkin SH. Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line. Molecular and Cellular Biology. 17: 1642-51. PMID 9032291  1
1997 Strauss EC, Orkin SH. Guanine-adenine ligation-mediated PCR in vivo footprinting Methods: a Companion to Methods in Enzymology. 11: 164-170. PMID 8993028 DOI: 10.1006/meth.1996.0402  1
1997 Strauss EC, Orkin SH. Analysis of the GATA-1 Gene Promoter and Globin Locus Control Region Elements by in Vivo Footprinting Advances in Molecular and Cell Biology. 21: 135-158. DOI: 10.1016/S1569-2558(08)60285-4  1
1996 Orkin SH. Development of the hematopoietic system Current Opinion in Genetics and Development. 6: 597-602. PMID 8939717 DOI: 10.1016/S0959-437X(96)80089-X  1
1996 Kieran MW, Perkins AC, Orkin SH, Zon LI. Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor. Proceedings of the National Academy of Sciences of the United States of America. 93: 9126-31. PMID 8799165  1
1996 Blobel GA, Orkin SH. Estrogen-induced apoptosis by inhibition of the erythroid transcription factor GATA-1 Molecular and Cellular Biology. 16: 1687-1694. PMID 8657144  1
1996 Shivdasani RA, Orkin SH. The transcriptional control of hematopoiesis Blood. 87: 4025-4039. PMID 8639758  1
1996 Kotkow KJ, Orkin SH. Complexity of the erythroid transcription factor NF-E2 as revealed by gene targeting of the mouse p18 NF-E2 locus Proceedings of the National Academy of Sciences of the United States of America. 93: 3514-3518. PMID 8622968 DOI: 10.1073/pnas.93.8.3514  1
1996 Weiss MJ, Orkin SH. In vitro differentiation of murine embryonic stem cells: New approaches to old problems Journal of Clinical Investigation. 97: 591-595. PMID 8609212  1
1996 Weiss MJ, Orkin SH. In vitro differentiation of murine embryonic stem cells new approaches to old problems Journal of Clinical Investigation. 98.  1
1995 Orkin SH. Hematopoiesis: how does it happen? Current Opinion in Cell Biology. 7: 870-877. PMID 8608018 DOI: 10.1016/0955-0674(95)80072-7  1
1995 Orkin SH. Transcription factors and hematopoietic development Journal of Biological Chemistry. 270: 4955-4958. PMID 7890597  1
1995 Shivdasanl RA, Mayer EL, Orkin SH. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL Nature. 373: 432-434. PMID 7830794 DOI: 10.1038/373432a0  0.32
1995 Weiss MJ, Orkin SH. GATA transcription factors: Key regulators of hematopoiesis Experimental Hematology. 23: 99-107. PMID 7828675  1
1995 Parkins AC, Sharpe AH, Orkin SH. Lethal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF Nature. 375: 318-322. PMID 7753195  1
1995 Crossley M, Merika M, Orkin SH. Self-association of the erythroid transcription factor GATA-1 mediated by its zinc finger domains Molecular and Cellular Biology. 15: 2448-2456. PMID 7739529  1
1995 Merika M, Orkin SH. Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Kruppel family proteins Sp1 and EKLF Molecular and Cellular Biology. 15: 2437-2447. PMID 7739528  1
1995 Chui DHK, Tang W, Orkin SH. cDNA cloning of murine Nrf 2 gene, coding for a p45 NF-E2 related transcription factor Biochemical and Biophysical Research Communications. 209: 40-46. PMID 7726861 DOI: 10.1006/bbrc.1995.1467  1
1995 Skoda RC, Tsai SF, Orkin SH, Leder P. Expression of c-MYC under the control of GATA-1 regulatory sequences causes erythroleukemia in transgenic mice. The Journal of Experimental Medicine. 181: 1603-13. PMID 7722440  1
1995 Orkin SH. Regulation of globin gene expression in erythroid cells European Journal of Biochemistry. 231: 271-281. PMID 7635138 DOI: 10.1111/j.1432-1033.1995.tb20697.x  1
1995 Kotkow KJ, Orkin SH. Dependence of globin gene expression in mouse erythroleukemia cells on the NF-E2 heterodimer Molecular and Cellular Biology. 15: 4640-4647. PMID 7623856  1
1995 Weiss MJ, Orkin SH. Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis Proceedings of the National Academy of Sciences of the United States of America. 92: 9623-9627. PMID 7568185 DOI: 10.1073/pnas.92.21.9623  1
1995 Shivdasani RA, Orkin SH. Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2 Proceedings of the National Academy of Sciences of the United States of America. 92: 8690-8694. PMID 7567998 DOI: 10.1073/pnas.92.19.8690  1
1995 Lewis BA, Orkin SH. A functional initiator element in the human β-globin promoter Journal of Biological Chemistry. 270: 28139-28144. PMID 7499303 DOI: 10.1074/jbc.270.47.28139  1
1994 Andrews NC, Orkin SH. Transcriptional control of erythropoiesis Current Opinion in Hematology. 1: 119-124. PMID 9371270  1
1994 Crossley M, Orkin SH. Phosphorylation of the erythroid transcription factor GATA-1 Journal of Biological Chemistry. 269: 16589-16596. PMID 8206977  1
1994 Crossley M, Tsang AP, Bieker JJ, Orkin SH. Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1 Journal of Biological Chemistry. 269: 15440-15444. PMID 8195185  1
1994 Weiss MJ, Keller G, Orkin SH. Novel insights into erythroid development revealed through in vitro differentiation of GATA-1- embryonic stem cells Genes and Development. 8: 1184-1197. PMID 7926723  1
1994 Aufiero B, Neufeld EJ, Orkin SH. Sequence-specific DNA binding of individual cut repeats of the human CCAAT displacement/cut homeodomain protein Proceedings of the National Academy of Sciences of the United States of America. 91: 7757-7761. PMID 7914370 DOI: 10.1073/pnas.91.16.7757  1
1994 Zhang R, Tsai FY, Orkin SH. Hematopoietic development of vav-/- mouse embryonic stem cells Proceedings of the National Academy of Sciences of the United States of America. 91: 12755-12759. PMID 7809116  1
1993 Zon LI, Yamaguchi Y, Yee K, Albee EA, Kimura A, Bennett JC, Orkin SH, Ackerman SJ. Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription. Blood. 81: 3234-41. PMID 8507862  1
1993 Crossley M, Orkin SH. Regulation of the β-globin locus Current Opinion in Genetics and Development. 3: 232-237. PMID 8504248 DOI: 10.1016/0959-437X(93)90028-N  1
1993 Merika M, Orkin SH. DNA-binding specificity of GATA family transcription factors Molecular and Cellular Biology. 13: 3999-4010. PMID 8321207  1
1992 Orkin SH. GATA-binding transcription factors in hematopoietic cells Blood. 80: 575-581. PMID 1638017  1
1992 Sposi NM, Zon LI, Carè A, Valtieri M, Testa U, Gabbianelli M, Mariani G, Bottero L, Mather C, Orkin SH. Cell cycle-dependent initiation and lineage-dependent abrogation of GATA-1 expression in pure differentiating hematopoietic progenitors. Proceedings of the National Academy of Sciences of the United States of America. 89: 6353-7. PMID 1631130  1
1992 Strauss EC, Orkin SH. In vivo protein-DNA interactions at hypersensitive site 3 of the human β- globin locus control region Proceedings of the National Academy of Sciences of the United States of America. 89: 5809-5813. PMID 1631062 DOI: 10.1073/pnas.89.13.5809  1
1992 Zon LI, Orkin SH. Sequence of the human GATA-1 promoter Nucleic Acids Research. 20: 1812. PMID 1579480 DOI: 10.1093/nar/20.7.1812  1
1992 Aplan PD, Nakahara K, Orkin SH, Kirsch IR. The SCL gene product: A positive regulator of erythroid differentiation Embo Journal. 11: 4073-4081. PMID 1396592  1
1991 Tsai SF, Strauss E, Orkin SH. Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter Genes and Development. 5: 919-931. PMID 2044960  1
1991 Zon LI, Mather C, Burgess S, Bolce ME, Harland RM, Orkin SH. Expression of GATA-binding proteins during embryonic development in Xenopus laevis. Proceedings of the National Academy of Sciences of the United States of America. 88: 10642-6. PMID 1961730  1
1991 Skalnik DG, Strauss EC, Orkin SH. CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter Journal of Biological Chemistry. 266: 16736-16744. PMID 1885602  1
1991 Zon LI, Gurish MF, Stevens RL, Mather C, Reynolds DS, Austen KF, Orkin SH. GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. The Journal of Biological Chemistry. 266: 22948-53. PMID 1744088  1
1991 Zon LI, Youssoufian H, Mather C, Lodish HF, Orkin SH. Activation of the erythropoietin receptor promoter by transcription factor GATA-1. Proceedings of the National Academy of Sciences of the United States of America. 88: 10638-41. PMID 1660143  1
1990 Wilson DB, Dorfman DM, Orkin SH. A nonerythroid GATA-binding protein is required for function of the human preproendothelin-1 promoter in endothelial cells Molecular and Cellular Biology. 10: 4854-4862. PMID 2388628  1
1990 Martin DI, Zon LI, Mutter G, Orkin SH. Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages. Nature. 344: 444-7. PMID 2320112 DOI: 10.1038/344444a0  1
1990 Zon LI, Tsai SF, Burgess S, Matsudaira P, Bruns GAP, Orkin SH. The major human erythroid DNA-binding protein (GF-1): Primary sequence and localization of the gene to the X chromosome Proceedings of the National Academy of Sciences of the United States of America. 87: 668-672. PMID 2300555  1
1990 Martin DIK, Orkin SH. Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1 Genes and Development. 4: 1886-1898. PMID 2276623  1
1990 Orkin SH. Preparing for the next generation: Presidential address to the American Society for Clinical Investigation, Washington, DC, 7 May 1990 Journal of Clinical Investigation. 86: 1773-1776. PMID 2254443  1
1990 Orkin SH. Globin gene regulation and switching: Circa 1990 Cell. 63: 665-672. PMID 2225071 DOI: 10.1016/0092-8674(90)90133-Y  1
1990 Youssoufian H, Zon LI, Orkin SH, D'Andrea AD, Lodish HF. Structure and transcription of the mouse erythropoietin receptor gene. Molecular and Cellular Biology. 10: 3675-82. PMID 2162479  1
1990 Orkin SH. Cell-specific transcription and cell differentiation in the erythroid lineage Current Opinion in Cell Biology. 2: 1003-1012. PMID 1966005 DOI: 10.1016/0955-0674(90)90149-9  1
1990 Whitelaw E, Tsai SF, Hogben P, Orkin SH. Regulated expression of globin chains and the erythroid transcription factor GATA-1 during erythropoiesis in the developing mouse Molecular and Cellular Biology. 10: 6596-6606. PMID 1701019  1
1989 Hirschhorn R, Tzall S, Ellenbogen A, Orkin SH. Identification of a point mutation resulting in a heat-labile adenosine deaminase (ADA) in two unrelated children with partial ADA deficiency Journal of Clinical Investigation. 83: 497-501. PMID 2783588  1
1989 Wise RJ, Orkin SH, Collins T. Aberrant expression of platelet-derived growth factor a-chaln cDNAs due to cryptic spiking of RNA transcripts in COS-1 cells Nucleic Acids Research. 17: 6591-6601. PMID 2780289 DOI: 10.1093/nar/17.16.6591  1
1989 Tsai SF, Martin DI, Zon LI, D'Andrea AD, Wong GG, Orkin SH. Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature. 339: 446-51. PMID 2725678 DOI: 10.1038/339446a0  1
1989 Zon LI, Dorfman DM, Orkin SH. The polymerase chain reaction colony miniprep Biotechniques. 7: 696-698. PMID 2631784  1
1989 Lim B, Apperley JF, Orkin SH, Williams DA. Long-term expression of human adenosine deaminase in mice transplanted with retrovirus-infected hematopoietic stem cells Proceedings of the National Academy of Sciences of the United States of America. 86: 8892-8896. PMID 2573068 DOI: 10.1073/pnas.86.22.8892  1
1989 Dinauer MC, Curnutte JT, Rosen H, Orkin SH. A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome-positive X-linked chronic granulomatous disease Journal of Clinical Investigation. 84: 2012-2016. PMID 2556453  1
1989 Dorfman DM, Zon LI, Orkin SH. Rapid amplification of lambda gt11 bacteriophage library inserts from plaques using the polymerase chain reaction (PCR) Biotechniques. 7. PMID 2534350  1
1989 Orkin SH. Molecular genetics of chronic granulomatous disease Annual Review of Immunology. 7: 277-307. PMID 2523713  1
1989 Orkin SH. X-linked chronic granulomatous disease: More than two years later Molecular Biology and Medicine. 6: 1-5. PMID 2502702  1
1989 Martin DI, Orkin SH. An erythroid-specific DNA binding factor mediates increased gamma-globin expression in hereditary persistence of fetal hemoglobin (HPFH) Progress in Clinical and Biological Research. 316: 217-228. PMID 2480608  1
1989 Martin DIK, Tsai SF, Orkin SH. Increased γ-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA-binding factor Nature. 338: 435-438. PMID 2467208  1
1988 Collins T, Bonthron DT, Orkin SH. Alternative RNA splicing affects function of encoded platelet-derived growth factor A chain Nature. 328: 621-624. PMID 3614364  1
1988 Bonthron DT, Morton CC, Orkin SH, Collins T. Platelet-derived growth factor A chain: Gene structure, chromosomal location, and basis for alternative mRNA splicing Proceedings of the National Academy of Sciences of the United States of America. 85: 1492-1496. PMID 3422746  1
1988 Dinauer MC, Orkin SH. Chronic granulomatous disease. Molecular genetics Hematology/Oncology Clinics of North America. 2: 225-240. PMID 3292508  1
1988 Orkin SH, Williams DA. Gene therapy of somatic cells: status and prospects Progress in Medical Genetics. 7: 130-142. PMID 3277251  1
1988 Bonthron D, Orkin SH. The human von Willebrand factor gene. Structure of the 5' region European Journal of Biochemistry. 171: 51-57. PMID 2828057  1
1987 Lim B, Williams DA, Orkin SH. Retrovirus-mediated gene transfer of human adenosine deaminase: expression of functional enzyme in murine hematopoietic stem cells in vivo Molecular and Cellular Biology. 7: 3459-3465. PMID 3683389  1
1987 Orkin SH. Genetic diagnosis by DNA analysis: progress through amplification New England Journal of Medicine. 317: 1023-1025. PMID 3657858  1
1987 Williams DA, Lim B, Orkin SH. Transfer and expression of human ADA in murine hematopoietic stem cells Progress in Clinical and Biological Research. 251: 567-580. PMID 3432278  1
1987 Orkin SH. "Forward" and "reverse" genetics of inherited human disorders: the thalassemia syndromes and chronic granulomatous disease Harvey Lectures. 83: 57-76. PMID 3334140  1
1987 Ezekowitz RAB, Orkin SH, Newburger PE. Recombinant interferon gamma augments phagocyte superoxide production and X-chronic granulomatous disease gene expression in X-linked variant chronic granulomatous disease Journal of Clinical Investigation. 80: 1009-1016. PMID 2821069  1
1987 Orkin SH. The pitfalls of sequencing: revised sequence of the X-CGD gene Trends in Genetics. 3: 207. DOI: 10.1016/0168-9525(87)90236-8  1
1987 Orkin SH. X-linked chronic granulomatous disease: from chromosomal position to the in vivo gene product Trends in Genetics. 3: 149-151. DOI: 10.1016/0168-9525(87)90215-0  1
1987 Williams DA, Orkin SH. Molecular techniques in hematopoiesis: Retroviral-mediated gene transfer into hematopoietic stem cells Hematology Reviews and Communications. 2: 1-12.  1
1986 Orkin SH. Molecular genetics and potential gene therapy Clinical Immunology and Immunopathology. 40: 151-156. PMID 3521968 DOI: 10.1016/0090-1229(86)90080-2  1
1986 Williams DA, Orkin SH. Somatic gene therapy. Current status and future prospects Journal of Clinical Investigation. 77: 1053-1056. PMID 3514670  1
1986 Williams DA, Orkin SH, Mulligan RC. Retrovirus-mediated transfer of human adenosine deaminase gene sequences into cells in culture and into murine hematopoietic cells in vivo. Proceedings of the National Academy of Sciences of the United States of America. 83: 2566-70. PMID 3458218  1
1986 Orkin SH. Reverse genetics and human disease Cell. 47: 845-850. PMID 2430724 DOI: 10.1016/0092-8674(86)90799-3  1
1985 Antonarakis SE, Kazazian HH, Orkin SH. DNA polymorphism and molecular pathology of the human globin gene clusters Human Genetics. 69: 1-14. PMID 3881334 DOI: 10.1007/BF00295521  1
1985 Prochownik EV, Block SC, Orkin SH. Intron structure of the human antithrombin III gene differs from that of other members of the serine protease inhibitor superfamily Journal of Biological Chemistry. 260: 9608-9612. PMID 2991253  1
1984 Orkin SH, Antonarakis SE, Loukopoulos D. Abnormal processing of β(Knossos) RNA Blood. 64: 311-313. PMID 6733281  1
1984 Orkin SH. Molecular analysis of human disease: Dissection of β-thalassemia Clinical Research. 32: 329-333. PMID 6488699  1
1984 Orkin SH, Goldman DS, Sallan SE. Development of homozygosity for chromosome 11p markers in Wilms' tumour Nature. 309: 172-174. PMID 6325937 DOI: 10.1038/309172a0  1
1984 Orkin SH. Prenatal diagnosis of hemoglobin disorders by DNA analysis Blood. 63: 249-253. PMID 6318864  1
1984 Platt OS, Orkin SH, Dover G, Beardsley GP, Miller B, Nathan DG. Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia. The Journal of Clinical Investigation. 74: 652-6. PMID 6205021 DOI: 10.1172/JCI111464  1
1984 Prochownik EV, Orkin SH. In vivo transcription of a human antithrombin III 'minigene' Journal of Biological Chemistry. 259: 15386-15392. PMID 6096369  1
1984 Orkin SH, Antonarakis SE, Kazazian HH. Base substitution at position -88 in a β-thalassemic globin gene. Further evidence for the role of distal promoter element ACACCC Journal of Biological Chemistry. 259: 8679-8681. PMID 6086605  1
1984 Orkin SH, Kazazian HH. The mutation and polymorphism of the human beta-globin gene and its surrounding DNA Annual Review of Genetics. 18: 131-171. PMID 6084979  1
1983 Orkin SH, Markham AF, Kazazian HH. Direct detection of the common Mediterranean β-thalassemia gene with synthetic DNA probes. An alternative approach for prenatal diagnosis Journal of Clinical Investigation. 71: 775-779. PMID 6826735  1
1983 Orkin SH, Antonarakis SE, Kazazian HH. Polymorphism and molecular pathology of the human beta-globin gene Progress in Hematology. 13: 49-73. PMID 6366914  1
1983 Treisman R, Orkin SH, Maniatis T. Structural and functional defects in beta-thalassemia Progress in Clinical and Biological Research. 134: 99-121. PMID 6320218  1
1983 Michelson AM, Orkin SH. Boundaries of gene conversion within the duplicated human α-globin genes. Concerted evolution by segmental recombination Journal of Biological Chemistry. 258: 15245-15234. PMID 6317690  1
1983 Michelson AM, Markham AF, Orkin SH. Isolation and DNA sequence of a full-length cDNA clone for human X chromosome-encoded phosphoglycerate kinase Proceedings of the National Academy of Sciences of the United States of America. 80: 472-476. PMID 6188151  1
1983 Treisman R, Orkin SH, Maniatis T. Specific transcription and RNA splicing defects in five cloned β-thalassaemia genes Nature. 302: 591-596. PMID 6188062 DOI: 10.1038/302591a0  1
1983 Orkin SH. Gene therapy: Controlling the fetal globin switch in man Nature. 301: 108-109. PMID 6185847 DOI: 10.1038/301108a0  1
1982 Spritz RA, Orkin SH. Duplication followed by deletion accounts for the structure of an Indian deletion β-thalassemia gene Nucleic Acids Research. 10: 8025-8029. PMID 7162987 DOI: 10.1093/nar/10.24.8025  1
1982 Felber BK, Orkin SH, Hamer DH. Abnormal RNA splicing causes one form of alpha thalassemia. Cell. 29: 895-902. PMID 7151175 DOI: 10.1016/0092-8674(82)90451-2  1
1982 Michelson AM, Orkin SH. Characterization of the homopolymer tailing reaction catalyzed by terminal deoxynucleotidyl transferase. Implications for the cloning of cDNA Journal of Biological Chemistry. 257: 14773-14782. PMID 6294077  1
1982 Orkin SH. Genetic diagnosis of the fetus Nature. 296: 202-203. PMID 6278319 DOI: 10.1038/296202a0  1
1981 Orkin SH, Goff SC. The duplicated human alpha-globin genes: their relative expression as measured by RNA analysis. Cell. 24: 345-51. PMID 7237552 DOI: 10.1016/0092-8674(81)90324-X  1
1981 Orkin SH, Goff SC. Nonsense and frameshift mutations in beta 0-thalassemia detected in cloned beta-globin genes. The Journal of Biological Chemistry. 256: 9782-4. PMID 6985481  1
1981 Orkin SH, Goff SC, Hechtman RL. Mutation in an intervening sequence splice junction in man. Proceedings of the National Academy of Sciences of the United States of America. 78: 5041-5. PMID 6946451  1
1981 Orkin SH, Nathan DG. The molecular genetics of thalassemia Advances in Human Genetics. 11: 233-280. PMID 6267910  1
1981 Orkin SH, Goff SC, Nathan DG. Heterogeneity of DNA deletion in gamma delta beta-thalassemia. The Journal of Clinical Investigation. 67: 878-84. PMID 6162860  1
1980 Michelson AM, Orkin SH. The 3' untranslated regions of the duplicated human α-globin genes are unexpectedly divergent Cell. 22: 371-377. PMID 7448866  1
1980 Orkin SH, Michelson A. Partial deletion of the α-globin structural gene in human α-thalassaemia Nature. 286: 538-540. PMID 7402334 DOI: 10.1038/286538a0  1
1980 Orkin SH. The alpha thalassemias Texas Reports On Biology and Medicine. 335-342. PMID 7034275  1
1980 Orkin SH, Kolodner R, Michelson A, Husson R. Cloning and direct examination of a structurally abnormal human β0-thalassemia globin gene Proceedings of the National Academy of Sciences of the United States of America. 77: 3558-3562. PMID 6251466  1
1980 Orkin SH. SPECIFIC ABNORMALITIES OF GLOBIN GENE ORGANIZATION IN THE THALASSEMIA SYNDROMES Annals of the New York Academy of Sciences. 344: 48-61. PMID 6249172 DOI: 10.1111/j.1749-6632.1980.tb33648.x  0.32
1979 Orkin SH, Alter BP, Altay C. Deletion of the Aγ-globin gene in Gγ-δβ-thalassemia Journal of Clinical Investigation. 64: 866-869. PMID 468997  1
1978 Orkin SH. Fidelity of globin ribonucleic acid synthesis in vitro by isolated nuclei: Asymmetric gene expression Biochemistry. 17: 487-492. PMID 620004  1
1978 Orkin SH. Selective restriction endonuclease cleavage of human globin genes Journal of Biological Chemistry. 253: 12-15. PMID 618852  1
1978 Orkin SH. Differentiation of murine erythroleukemic (friend) cells: An in vitro model of erythropoiesis In Vitro. 14: 146-154. PMID 342390 DOI: 10.1007/BF02618181  1
1978 Orkin SH. The duplicated human α globin genes lie close together in cellular DNA Proceedings of the National Academy of Sciences of the United States of America. 75: 5950-5954. PMID 282616  1
1977 Orkin SH. In vitro synthesis of a DNA probe for antisense globin sequences Journal of Biological Chemistry. 252: 5606-5608. PMID 885869  1
1977 Orkin SH, Swerdlow PS. Globin RNA synthesis in vitro by isolated erythroleukemic cell nuclei: Direct evidence for increased transcription during erythroid differentiation Proceedings of the National Academy of Sciences of the United States of America. 74: 2475-2479. PMID 267941  1
1976 Orkin SH, Nathan DG. Current concepts in genetics. The thalassemias New England Journal of Medicine. 295: 710-714. PMID 785253  1
1975 Orkin SH, Swan D, Leder P. Differential expression of α and β globin genes during differentiation of cultured erythroleukemic cells Journal of Biological Chemistry. 250: 8753-8760. PMID 1237491  1
1975 Orkin SH, Harosi FI, Leder P. Differentiation in erythroleukemic cells and their somatic hybrids Proceedings of the National Academy of Sciences of the United States of America. 72: 98-102. PMID 164031  1
1971 Orkin SH, Littlefield JW. Mutagenesis to aminopterin resistance in cultured hamster cells Experimental Cell Research. 69: 174-180. PMID 5166371 DOI: 10.1016/0014-4827(71)90322-3  1
1971 Orkin SH, Littlefield JW. Nitrosoguanidine mutagenesis in synchronized hamster cells Experimental Cell Research. 66: 69-74. DOI: 10.1016/S0014-4827(71)80012-5  1
1967 Dowben RM, Orkin SH. Extrinsic cotton effects in dye-bovine plasma albumin adducts Proceedings of the National Academy of Sciences of the United States of America. 58: 2051-2054. PMID 5237498  1
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